CN116504214A

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Info

Publication number: CN116504214A
Application number: CN202310775444.1A
Authority: CN
Inventors: 白洋; 冯珍
Original assignee: First Affiliated Hospital of Nanchang University
Current assignee: First Affiliated Hospital of Nanchang University
Priority date: 2023-06-28
Filing date: 2023-06-28
Publication date: 2023-07-28
Anticipated expiration: 2043-06-28
Also published as: CN116504214B

Abstract

Translated fromChinese

本申请公开了一种颅磁刺激掩蔽噪声生成装置、电子设备及存储介质。包括：播放掩蔽噪声A_i‑1，采集多个线圈通道对应的多个第一声音信号；对多个第一声音信号进行加工处理，得到第二声音信号B_i；在多个线圈通道上采集与多个第一脉冲中每个第一脉冲对应的多个第一脑电信号；对每个第一脉冲对应的多个第一脑电信号进行听觉诱发电位分析，得到听觉诱发电位判定结果C_i在听觉诱发电位判定结果C_i不满足预设条件时，根据听觉诱发电位判定结果C_i确定声音调制参数D_i，以对第二声音信号B_i进行调制，得到第i+1次经颅磁测试的掩蔽噪声A_i，进行第i+1次经颅磁测试，直至满足预设条件；否则，将掩蔽噪声A_i‑1作为目标掩蔽噪声。

The application discloses a cranial magnetic stimulation masking noise generating device, electronic equipment and a storage medium. Including: playing masking noise A_i‑1 , collecting multiple first sound signals corresponding to multiple coil channels; processing multiple first sound signals to obtain a second sound signal B_i ; collecting on multiple coil channels A plurality of first EEG signals corresponding to each first pulse in the plurality of first pulses; performing auditory evoked potential analysis on the plurality of first EEG signals corresponding to each first pulse to obtain an auditory evoked potential determination result C_i When the auditory evoked potential judgment result C_i does not meet the preset conditions, the sound modulation parameter D_{i is determined according to the auditory evoked potential judgment result C i}_to modulate the second sound signal_Bi to obtain the i+1th transcranial For the masking noise A_i of the magnetic test, the i+1th transcranial magnetic test is performed until the preset condition is met; otherwise, the masking noise A_i‑1 is used as the target masking noise.

Description

Translated fromChinese

颅磁刺激掩蔽噪声生成装置、电子设备及存储介质Cranial magnetic stimulation masking noise generating device, electronic equipment and storage medium

技术领域technical field

本发明涉及医疗技术领域，具体涉及一种颅磁刺激掩蔽噪声生成装置、电子设备及存储介质。The invention relates to the field of medical technology, in particular to a cranial magnetic stimulation masking noise generating device, electronic equipment and a storage medium.

背景技术Background technique

经颅磁刺激技术通过放置在头皮上的线圈产生核磁共振等量强度的磁场，并且无衰减地穿透颅骨作用到脑组织上，从而去极化神经元，诱发出神经冲动传导。通过对神经元兴奋性、网络性和可塑性的影响来实现大脑皮层的功能重组。由于经颅磁刺激技术具有无痛、安全、价廉、适应性强，可塑性高等优点，已经在精神和神经性疾病的神经功能康复治疗中展现出重要应用价值。Transcranial magnetic stimulation technology generates a magnetic field of the same strength as nuclear magnetic resonance through a coil placed on the scalp, and penetrates the skull without attenuation to act on the brain tissue, thereby depolarizing neurons and inducing nerve impulse conduction. Functional reorganization of the cerebral cortex through effects on neuronal excitability, networking, and plasticity. Because transcranial magnetic stimulation technology has the advantages of painlessness, safety, low cost, strong adaptability, and high plasticity, it has shown important application value in the neurological rehabilitation treatment of mental and neurological diseases.

但是由于脑电对电磁环境的敏感性，两种技术的结合在脑电噪声处理方面提出了极高的要求。在经颅磁刺激诱发脑电技术中，经颅磁刺激脉冲在线圈中产生的“嘀嘀”噪声会通过空气和骨传导到人脑听觉感应区，从而诱发出噪声相关的听觉诱发信号。这种听觉诱发信号极大地干扰了对经颅磁诱发神经响应信号的判别和解读。因此，对线圈噪声的屏蔽是经颅磁刺激诱发脑电技术的难点。However, due to the sensitivity of EEG to the electromagnetic environment, the combination of the two technologies puts forward extremely high requirements in the processing of EEG noise. In the transcranial magnetic stimulation-induced EEG technology, the "beep" noise generated by the transcranial magnetic stimulation pulse in the coil will be conducted to the auditory induction area of the human brain through air and bone, thereby inducing noise-related auditory evoked signals. This auditory evoked signal greatly interferes with the discrimination and interpretation of the transcranial magnetically evoked neural response signal. Therefore, the shielding of coil noise is a difficult point in the technique of transcranial magnetic stimulation-induced EEG.

当前，通常会在经颅磁刺激诱发脑电评估中，让被试或者患者带上耳塞，以减少噪声的影响。但是这种方式只能减弱噪声的干扰，在诱发神经响应信号中仍然保留清晰的听觉诱发电位，因此无法屏蔽这种噪声的干扰。此外，实验研究也会采用一种外放噪声的方式用以减弱听觉噪声的影响。比如在被试或病人耳朵中通过入耳式耳机播放白噪声，或者采集线圈中产生的“嘀嘀”噪声，经过声音处理后再通过耳机回放给被试。这种方法可以有效屏蔽听觉诱发电位。但是，目前的技术通常是让被试或者患者自己调节音量以达到掩盖线圈噪声的大小。这种方式下存在很多弊端，第一由于听觉噪声音量与真实的大脑皮层听觉诱发电位没有明确一对一的对应关系，被试通过主观感受调节的音量大小可能过大或者过小，造成被试感觉难受或者噪声屏蔽失败。第二由于这种方式需要被试或者患者主动调节音量，这决定了这种方法在脑疾病临床患者中失效。因为很多脑损伤患者无法主动配合地去调节声音大小。At present, in the evaluation of EEG induced by transcranial magnetic stimulation, the subjects or patients are usually asked to wear earplugs to reduce the influence of noise. However, this method can only weaken the interference of noise, and still retain a clear auditory evoked potential in the evoked neural response signal, so it cannot shield the interference of this noise. In addition, the experimental research will also use a way of external noise to reduce the impact of auditory noise. For example, white noise is played through in-ear headphones in the ears of the subjects or patients, or the "di-di" noise generated in the acquisition coil is processed and then played back to the subjects through the headphones. This method can effectively shield the auditory evoked potential. However, the current technology usually allows the subjects or patients to adjust the volume to cover the coil noise. There are many disadvantages in this method. First, because there is no clear one-to-one correspondence between the volume of auditory noise and the real auditory evoked potential of the cerebral cortex, the volume adjusted by the subject through subjective feeling may be too large or too small, causing the subject Feeling sick or noise masking failure. Second, because this method requires the subject or patient to actively adjust the volume, this method is ineffective in clinical patients with brain diseases. Because many brain-damaged patients cannot actively and cooperatively adjust the volume of their voices.

发明内容Contents of the invention

为了解决现有技术中存在的上述问题，本申请实施方式提供了一种颅磁刺激掩蔽噪声生成装置、电子设备及存储介质，可以自动生成高精准度的掩蔽噪音，以降低由线圈噪声所诱发的听觉噪声。In order to solve the above-mentioned problems existing in the prior art, the embodiment of the present application provides a CMS masking noise generation device, electronic equipment and storage media, which can automatically generate high-precision masking noise to reduce the noise induced by coil noise. auditory noise.

第一方面，本申请的实施方式提供了一种颅磁刺激掩蔽噪声生成装置，该装置包括：脑电采集模块、噪声采集模块、听觉诱发电位分析模块、噪声处理模块和声音调制模块；In the first aspect, the embodiment of the present application provides a masking noise generation device for cranial magnetic stimulation, which includes: an EEG acquisition module, a noise acquisition module, an auditory evoked potential analysis module, a noise processing module, and a sound modulation module;

噪声采集模块，用于在第i次经颅磁测试中，播放掩蔽噪声A_i-1的情况下，采集多个线圈通道对应的多个第一声音信号，其中，i为大于或等于1的整数，掩蔽噪声A_i-1由第i-1次经颅磁测试确定；The noise collection module is used to collect a plurality of first sound signals corresponding to a plurality of coil channels in the case of playing masking noise A_i-1 in the i-th transcranial magnetic test, wherein i is greater than or equal to 1 Integer, the masking noise A_i-1 is determined by the i-1th transcranial magnetic test;

噪声处理模块，用于对多个第一声音信号进行加工处理，得到第二声音信号B_i；A noise processing module, configured to process a plurality of first sound signals to obtain a second sound signal B_i ;

脑电采集模块，用于在多个线圈通道上采集与多个第一脉冲中每个第一脉冲对应的多个第一脑电信号，其中，多个第一脑电信号与多个线圈通道一一对应，多个第一脑电信号的采集时段与多个第一声音信号的采集时段相同；The EEG acquisition module is used to acquire a plurality of first EEG signals corresponding to each first pulse in the plurality of first pulses on a plurality of coil channels, wherein, the plurality of first EEG signals and the plurality of coil channels One-to-one correspondence, the acquisition periods of the plurality of first EEG signals are the same as the acquisition periods of the plurality of first sound signals;

听觉诱发电位分析模块，用于对每个第一脉冲对应的多个第一脑电信号进行听觉诱发电位分析，得到听觉诱发电位判定结果C_i；An auditory evoked potential analysis module, configured to perform auditory evoked potential analysis on multiple first EEG signals corresponding to each first pulse, to obtain an auditory evoked potential determination result C_i ;

声音调制模块，用于在听觉诱发电位判定结果C_i不满足预设条件时，根据听觉诱发电位判定结果C_i对第i-1次经颅磁测试的声音调制参数D_i-1进行调整，得到声音调制参数D_i，并基于声音调制参数D_i对第二声音信号B_i进行调制，得到第i+1次经颅磁测试的掩蔽噪声A_i，进行第i+1次经颅磁测试，直至满足预设条件，其中，当i=1时，声音调制参数D₁为预设参数；The sound modulation module is used to adjust the sound modulation parameter D i-1_{of the} i-1 transcranial magnetic test according to the auditory evoked potential judgment result C_i when the auditory evoked potential judgment result C_i does not meet the preset condition, Obtain the sound modulation parameter D_i , and modulate the second sound signal B_i based on the sound modulation parameter D_i to obtain the masking noise A_i of the i+1 th transcranial magnetic test, and perform the i+1 th transcranial magnetic test , until the preset condition is met, wherein, when i=1, the sound modulation parameter_D1 is the preset parameter;

声音调制模块，还用于在听觉诱发电位判定结果C_i满足预设条件时，将掩蔽噪声A_i-1作为目标掩蔽噪声。The sound modulation module is further configured to use the masking noise A_i-1 as the target masking noise when the auditory evoked potential determination result C_i satisfies a preset condition.

在一种可能的实施方式中，在对多个第一声音信号进行加工处理，得到第二声音信号B_i方面，噪声处理模块，具体用于：In a possible implementation manner, in terms of processing a plurality of first sound signals to obtain the second sound signal_Bi , the noise processing module is specifically used for:

基于多个第一声音信号中的每个第一声音信号的幅值，对每个第一声音信号进行归一化处理，得到多个第三声音信号；Based on the amplitude of each first sound signal in the plurality of first sound signals, performing normalization processing on each first sound signal to obtain a plurality of third sound signals;

将多个第三声音信号随机串联，得到第四声音信号；Randomly connecting a plurality of third sound signals in series to obtain a fourth sound signal;

对第四声音信号的噪声频谱的相位进行随机打乱，并根据打乱后的噪声频谱重构出第五声音信号；Randomly scrambling the phase of the noise spectrum of the fourth sound signal, and reconstructing the fifth sound signal according to the scrambled noise spectrum;

对第五声音信号进行多次重采样，得到多个第六声音信号；performing multiple resampling on the fifth sound signal to obtain multiple sixth sound signals;

将多个第六声音信号叠加平均，得到第二声音信号B_i。A plurality of sixth sound signals are superimposed and averaged to obtain a second sound signal B_i .

在一种可能的实施方式中，在对第四声音信号的噪声频谱的相位进行随机打乱，并根据打乱后的噪声频谱重构出第五声音信号方面，噪声处理模块，具体用于：In a possible implementation manner, in random scrambling the phase of the noise spectrum of the fourth sound signal, and reconstructing the fifth sound signal according to the scrambled noise spectrum, the noise processing module is specifically used for:

对第四声音信号进行傅里叶频谱分析，得到第四声音信号的第一时间序列相位；Carrying out Fourier spectrum analysis to the fourth sound signal to obtain the first time series phase of the fourth sound signal;

将第一时间序列相位随机打乱重组，得到第二时间序列相位；Randomly disrupt and reorganize the phases of the first time series to obtain the phases of the second time series;

根据第二时间序列相位重构出第五声音信号。The fifth sound signal is reconstructed according to the second time series phase.

在一种可能的实施方式中，在对每个第一脉冲对应的多个第一脑电信号进行听觉诱发电位分析，得到听觉诱发电位判定结果C_i方面，听觉诱发电位分析模块，具体用于：In a possible implementation manner, in performing auditory evoked potential analysis on multiple first EEG signals corresponding to each first pulse to obtain the auditory evoked potential determination result_Ci , the auditory evoked potential analysis module is specifically used to :

对多个第一脑电信号中的每个第一脑电信号进行噪声去除处理，得到多个第二脑电信号，其中，多个第二脑电信号与多个第一脑电信号一一对应；Perform noise removal processing on each of the multiple first EEG signals to obtain multiple second EEG signals, wherein the multiple second EEG signals and the multiple first EEG signals are one by one correspond;

基于发放每个第一脉冲的时刻，对多个第二脑电信号中的每个第二脑电信号进行截取，得到多个第一信号片段和多个第二信号片段，其中，多个第一信号片段与多个第二脑电信号一一对应，多个第二信号片段与多个第二脑电信号一一对应；Based on the moment when each first pulse is issued, each second EEG signal in the plurality of second EEG signals is intercepted to obtain a plurality of first signal segments and a plurality of second signal segments, wherein the plurality of second EEG signals One signal segment is in one-to-one correspondence with multiple second EEG signals, and the multiple second signal segments are in one-to-one correspondence with multiple second EEG signals;

基于多个第一信号片段，确定第i次经颅磁测试中的听觉诱发成份；determining an auditory evoked component in the ith transcranial magnetic test based on the plurality of first signal segments;

基于多个第二信号片段，确定第i次经颅磁测试中的诱发成份；determining an evoked component in the ith transcranial magnetic test based on the plurality of second signal segments;

根据听觉诱发成份的幅值，与诱发成份的幅值，确定听觉诱发电位判定结果C_i。The auditory evoked potential judgment result C_i is determined according to the amplitude of the auditory evoked component and the amplitude of the evoked component.

在一种可能的实施方式中，在对多个第一脑电信号中的每个第一脑电信号进行噪声去除处理，得到多个第二脑电信号方面，听觉诱发电位分析模块，具体用于：In a possible implementation manner, in performing noise removal processing on each of the multiple first EEG signals to obtain multiple second EEG signals, the auditory evoked potential analysis module specifically uses At:

基于发放每个第一脉冲的时刻，分别对每个第一脉冲在每个第一脑电信号进行插值，得到多个第三脑电信号，其中，多个第三脑电信号与多个第一脑电信号一一对应；Based on the moment when each first pulse is issued, each first pulse is interpolated in each first EEG signal to obtain a plurality of third EEG signals, wherein the plurality of third EEG signals and the plurality of first EEG signals One-to-one correspondence of EEG signals;

针对多个第三脑电信号中的每个第三脑电信号，获取每个第三脑电信号在预设时间段内的幅值的均值；For each third EEG signal in the plurality of third EEG signals, obtain the mean value of the amplitude of each third EEG signal within a preset time period;

将每个第三脑电信号在各个时刻下的幅值减去均值，得到多个第四脑电信号，其中，多个第四脑电信号与多个第三脑电信号一一对应；Subtracting the mean value from the amplitude of each third EEG signal at each moment to obtain a plurality of fourth EEG signals, wherein the plurality of fourth EEG signals correspond to the plurality of third EEG signals one-to-one;

对多个第四脑电信号进行带通滤波，得到多个第五脑电信号；performing band-pass filtering on multiple fourth EEG signals to obtain multiple fifth EEG signals;

对多个第五脑电信号进行坏通道替换和坏数据段剔除，得到多个第六脑电信号；Performing bad channel replacement and bad data segment elimination on multiple fifth EEG signals to obtain multiple sixth EEG signals;

对多个第六脑电信号进行独立成分分析，得到多个第二脑电信号。Independent component analysis is performed on the multiple sixth EEG signals to obtain multiple second EEG signals.

在一种可能的实施方式中，在根据听觉诱发成份的幅值，与诱发成份的幅值，确定听觉诱发电位判定结果C_i方面，听觉诱发电位分析模块，具体用于：In a possible implementation manner, in terms of determining the auditory evoked potential determination result_Ci according to the amplitude of the auditory evoked component and the amplitude of the evoked component, the auditory evoked potential analysis module is specifically used for:

以发放每个第一脉冲的时刻为分割线，对每个第一脉冲在每个通道上的第二脑电信号进行信号分割，得到每个第一脉冲在每个通道上的基线信号；Taking the moment when each first pulse is issued as a dividing line, performing signal segmentation on the second EEG signal of each first pulse on each channel to obtain the baseline signal of each first pulse on each channel;

基于每个第一脉冲在每个通道上的基线信号的幅值进行高斯拟合，得到幅值阈值；Gaussian fitting is performed based on the amplitude of the baseline signal of each first pulse on each channel to obtain an amplitude threshold;

若听觉诱发成份的幅值高于或等于幅值阈值，或者诱发成份的幅值高于或等于幅值阈值，则判定听觉诱发电位判定结果C_i为存在听觉诱发电位，否则，判定听觉诱发电位判定结果C_i为没有听觉诱发电位。If the amplitude of the auditory evoked component is higher than or equal to the amplitude threshold, or if the amplitude of the evoked component is higher than or equal to the amplitude threshold, then the auditory evoked potential determination result C_i is determined to be an auditory evoked potential, otherwise, the auditory evoked potential is determined The judgment result C_i is that there is no auditory evoked potential.

在一种可能的实施方式中，在根据听觉诱发电位判定结果C_i对第i-1次经颅磁测试的声音调制参数D_i-1进行调整，得到声音调制参数D_i方面，声音调制模块，具体用于:In a possible implementation manner, in terms of adjusting the sound modulation parameter D_i-1 of the i-1th transcranial magnetic test according to the auditory evoked potential determination result C_i to obtain the sound modulation parameter D_i , the sound modulation module , specifically for:

基于预设的步进单位对声音调制参数D_i-1中的每个参数或部分参数进行步进调整，得到声音调制参数D_i。Each parameter or some of the parameters in the sound modulation parameter D_i-1 is stepwise adjusted based on a preset step unit to obtain the sound modulation parameter D_i .

第二方面，本申请的实施方式提供了一种颅磁刺激掩蔽噪声生成方法，该方法应用于颅磁刺激掩蔽噪声生成装置，装置包括脑电采集模块、噪声采集模块、听觉诱发电位分析模块、噪声处理模块和声音调制模块，方法包括：In the second aspect, the embodiment of the present application provides a method for generating masking noise for cranial magnetic stimulation, the method is applied to a device for generating masking noise for cranial magnetic stimulation, and the device includes an EEG acquisition module, a noise acquisition module, an auditory evoked potential analysis module, A noise processing module and a sound modulation module, the method comprising:

在第i次经颅磁测试中，播放掩蔽噪声A_i-1的情况下，噪声采集模块采集多个线圈通道对应的多个第一声音信号，其中，i为大于或等于1的整数，掩蔽噪声A_i-1由第i-1次经颅磁测试确定；In the i-th transcranial magnetic test, when the masking noise A_i-1 is played, the noise acquisition module collects multiple first sound signals corresponding to multiple coil channels, where i is an integer greater than or equal to 1, and the masking noise Noise A_i-1 is determined by the i-1th transcranial magnetic test;

噪声处理模块对多个第一声音信号进行加工处理，得到第二声音信号B_i；The noise processing module processes a plurality of first sound signals to obtain a second sound signal B_i ;

脑电采集模块在多个线圈通道上采集与多个第一脉冲中每个第一脉冲对应的多个第一脑电信号，其中，多个第一脑电信号与多个线圈通道一一对应，多个第一脑电信号的采集时段与多个第一声音信号的采集时段相同；The EEG acquisition module collects multiple first EEG signals corresponding to each of the multiple first pulses on multiple coil channels, wherein the multiple first EEG signals correspond to the multiple coil channels one by one , the acquisition periods of the plurality of first EEG signals are the same as the acquisition periods of the plurality of first sound signals;

听觉诱发电位分析模块对每个第一脉冲对应的多个第一脑电信号进行听觉诱发电位分析，得到听觉诱发电位判定结果C_i；The auditory evoked potential analysis module performs auditory evoked potential analysis on multiple first EEG signals corresponding to each first pulse, and obtains an auditory evoked potential determination result C_i ;

声音调制模块在听觉诱发电位判定结果C_i不满足预设条件时，根据听觉诱发电位判定结果C_i对第i-1次经颅磁测试的声音调制参数D_i-1进行调整，得到声音调制参数D_i，并基于声音调制参数D_i对第二声音信号B_i进行调制，得到第i+1次经颅磁测试的掩蔽噪声A_i，进行第i+1次经颅磁测试，直至满足预设条件，其中，当i=1时，声音调制参数D₁为预设参数；The sound modulation module adjusts the sound modulation parameter D_i-1 of the i-1 transcranial magnetic test according to the auditory evoked potential judgment result C_i when the auditory evoked potential judgment result C_i does not meet the preset conditions, and obtains the sound modulation parameter D_i , and modulate the second sound signal B_i based on the sound modulation parameter D_i to obtain the masking noise A_i of the i+1th transcranial magnetic test, and perform the i+1th transcranial magnetic test until the Preset conditions, wherein, when i=1, the sound modulation parameter_D1 is a preset parameter;

声音调制模块在听觉诱发电位判定结果C_i满足预设条件时，将掩蔽噪声A_i-1作为目标掩蔽噪声。The sound modulation module uses the masking noise A_i-1 as the target masking noise when the auditory evoked potential determination result C_i satisfies the preset condition.

第三方面，本申请实施方式提供一种电子设备，包括：处理器，处理器与存储器相连，存储器用于存储计算机程序，处理器用于执行存储器中存储的计算机程序，以使得电子设备执行如第二方面的方法。In a third aspect, an embodiment of the present application provides an electronic device, including: a processor, the processor is connected to a memory, the memory is used to store a computer program, and the processor is used to execute the computer program stored in the memory, so that the electronic device performs as described in two ways.

第四方面，本申请实施方式提供一种计算机可读存储介质，计算机可读存储介质存储有计算机程序，计算机程序使得计算机执行如第二方面的方法。In a fourth aspect, an embodiment of the present application provides a computer-readable storage medium, where a computer program is stored in the computer-readable storage medium, and the computer program causes a computer to execute the method of the second aspect.

第五方面，本申请实施方式提供一种计算机程序产品，计算机程序产品包括存储了计算机程序的非瞬时性计算机可读存储介质，计算机可操作来使计算机执行如第二方面的方法。In a fifth aspect, an embodiment of the present application provides a computer program product, the computer program product includes a non-transitory computer-readable storage medium storing a computer program, and the computer is operable to cause the computer to execute the method of the second aspect.

实施本申请实施方式，具有如下有益效果：Implementing the implementation mode of the present application has the following beneficial effects:

可以看出，在本申请实施方式中，通过对经颅磁诱发听觉电位进行检测，确定听觉诱发电位判定结果C_i，继而基于该判定结果对由多个线圈通道对应的多个第一声音信号加工得到的第二声音信号B_i进行调制，得到目标掩蔽噪声，以消除经颅磁刺激线圈噪声对诱发神经响应的影响。由此，通过自动闭环反馈式调节的方式，适配个体化适应，继而无需被试者或病人主动调节，即可实现个体化的精准掩蔽噪声的自动化生成。从而克服了现行方案中需要被试或病人主动调节噪声音量或噪声掩蔽效果不佳的缺陷，排除经颅磁刺激诱发脑电在脑评估中的人为主观影响。此外，本申请实施方式不依赖被试者或病人的操作，使得对经颅磁刺激线圈噪声的掩蔽能够适用于一些丧失主动行为能力的病人，从而保障了经颅磁刺激诱发神经反应评估能够运用于临床重症病人。It can be seen that in the embodiment of the present application, the auditory evoked potential judgment result C_i is determined by detecting the transcranial magnetically evoked auditory potential, and then based on the judgment result, multiple first sound signals corresponding to multiple coil channels The processed second sound signal B_i is modulated to obtain target masking noise, so as to eliminate the influence of the noise of the transcranial magnetic stimulation coil on the evoked nerve response. Therefore, through the automatic closed-loop feedback adjustment method, the individualized adaptation can be adapted, and then the automatic generation of individualized and accurate masking noise can be realized without active adjustment by the subject or patient. In this way, it overcomes the defect that the subject or patient actively adjusts the noise volume or the noise masking effect is not good in the current scheme, and excludes the artificial subjective influence of the EEG induced by transcranial magnetic stimulation in the brain evaluation. In addition, the embodiment of the present application does not rely on the operation of the subject or the patient, so that the masking of the noise of the transcranial magnetic stimulation coil can be applied to some patients who have lost their active behavior, thus ensuring that the evaluation of the neural response induced by transcranial magnetic stimulation can be used in clinical critically ill patients.

附图说明Description of drawings

为了更清楚地说明本申请实施方式中的技术方案，下面将对实施方式描述中所需要使用的附图作简单地介绍，显而易见地，下面描述中的附图是本申请的一些实施方式，对于本领域普通技术人员来讲，在不付出创造性劳动的前提下，还可以根据这些附图获得其他的附图。In order to more clearly illustrate the technical solutions in the embodiments of the present application, the following will briefly introduce the drawings that need to be used in the description of the embodiments. Obviously, the drawings in the following description are some embodiments of the application. Those of ordinary skill in the art can also obtain other drawings based on these drawings without making creative efforts.

图1为本申请实施方式提供的一种颅磁刺激掩蔽噪声生成装置的硬件结构示意图；FIG. 1 is a schematic diagram of the hardware structure of a masking noise generation device for cranial magnetic stimulation provided by an embodiment of the present application;

图2为本申请实施方式提供的一种颅磁刺激掩蔽噪声生成的场景示意图；FIG. 2 is a schematic diagram of a scene of generation of masking noise by cranial magnetic stimulation provided by an embodiment of the present application;

图3为本申请实施方式提供的一种颅磁刺激掩蔽噪声生成装置的示意图；FIG. 3 is a schematic diagram of a masking noise generation device for cranial magnetic stimulation provided by an embodiment of the present application;

图4为本申请实施方式提供的一种进行多个第一声音信号采集的示意图；FIG. 4 is a schematic diagram of collecting multiple first sound signals according to an embodiment of the present application;

图5为本申请实施方式提供的一种听觉诱发成份N100与诱发成份P200的示意图；Fig. 5 is a schematic diagram of an auditory inducing component N100 and an inducing component P200 provided by the embodiment of the present application;

图6为本申请实施方式提供的一种噪声调制的示意图；FIG. 6 is a schematic diagram of noise modulation provided by an embodiment of the present application;

图7为本申请实施方式提供的一种使用目标掩蔽噪声后，受试者脑电信号中的N100和P200的示意图；Fig. 7 is a schematic diagram of N100 and P200 in the subject's EEG signal after using the target to mask the noise provided by the embodiment of the present application;

图8为本申请实施方式提供的一种颅磁刺激掩蔽噪声生成装置的功能模块组成框图；Fig. 8 is a block diagram of the functional modules of a cranial magnetic stimulation masking noise generation device provided by an embodiment of the present application;

图9为本申请实施方式提供的一种电子设备的结构示意图。FIG. 9 is a schematic structural diagram of an electronic device provided in an embodiment of the present application.

具体实施方式Detailed ways

下面将结合本申请实施方式中的附图，对本申请实施方式中的技术方案进行清楚、完整地描述，显然，所描述的实施方式是本申请一部分实施方式，而不是全部的实施方式。基于本申请中的实施方式，本领域普通技术人员在没有作出创造性劳动前提下所获得的所有其他实施方式，都属于本申请保护的范围。The following will clearly and completely describe the technical solutions in the embodiments of the application with reference to the drawings in the embodiments of the application. Apparently, the described embodiments are part of the embodiments of the application, not all of them. Based on the implementation manners in this application, all other implementation manners obtained by persons of ordinary skill in the art without creative efforts shall fall within the scope of protection of this application.

本申请的说明书和权利要求书及所述附图中的术语“第一”、“第二”、“第三”和“第四”等是用于区别不同对象，而不是用于描述特定顺序。此外，术语“包括”和“具有”以及它们任何变形，意图在于覆盖不排他的包含。例如包含了一系列步骤或单元的过程、方法、系统、产品或设备没有限定于已列出的步骤或单元，而是可选地还包括没有列出的步骤或单元，或可选地还包括对于这些过程、方法、产品或设备固有的其它步骤或单元。The terms "first", "second", "third" and "fourth" in the specification and claims of the present application and the drawings are used to distinguish different objects, rather than to describe a specific order . Furthermore, the terms "include" and "have", as well as any variations thereof, are intended to cover a non-exclusive inclusion. For example, a process, method, system, product or device comprising a series of steps or units is not limited to the listed steps or units, but optionally also includes unlisted steps or units, or optionally further includes For other steps or units inherent in these processes, methods, products or apparatuses.

在本文中提及“实施方式”意味着，结合实施方式描述的特定特征、结果或特性可以包含在本申请的至少一个实施方式中。在说明书中的各个位置出现该短语并不一定均是指相同的实施方式，也不是与其它实施方式互斥的独立的或备选的实施方式。本领域技术人员显式地和隐式地理解的是，本文所描述的实施方式可以与其它实施方式相结合。Reference herein to "an embodiment" means that a particular feature, result, or characteristic described in connection with the embodiment can be included in at least one embodiment of the present application. The occurrences of this phrase in various places in the specification are not necessarily all referring to the same embodiment, nor are independent or alternative embodiments mutually exclusive of other embodiments. It is understood explicitly and implicitly by those skilled in the art that the embodiments described herein can be combined with other embodiments.

首先，为了便于理解本申请的技术方案，首先对本申请涉及到相关技术进行解释和说明。First of all, in order to facilitate the understanding of the technical solutions of the present application, the relevant technologies involved in the present application are firstly explained and explained.

经颅磁刺激诱发脑电技术在脑疾病的评估、诊断和预后方面展现了非常强的应用价值。但是由于脑电对电磁环境的敏感性，两种技术的结合在脑电噪声处理方面提出了极高的要求。在经颅磁刺激诱发脑电技术中，经颅磁刺激脉冲在线圈中产生的“滴滴”噪声会通过空气和骨传导到人脑听觉感应区，从而诱发出噪声相关的听觉诱发信号。这种听觉诱发信号极大地干扰了对经颅磁诱发神经响应信号的判别和解读。Transcranial magnetic stimulation-induced EEG technology has shown very strong application value in the assessment, diagnosis and prognosis of brain diseases. However, due to the sensitivity of EEG to the electromagnetic environment, the combination of the two technologies puts forward extremely high requirements in the processing of EEG noise. In the EEG technology induced by transcranial magnetic stimulation, the "didi" noise generated by the transcranial magnetic stimulation pulse in the coil will be conducted to the auditory induction area of the human brain through air and bone, thereby inducing noise-related auditory evoked signals. This auditory evoked signal greatly interferes with the discrimination and interpretation of the transcranial magnetically evoked neural response signal.

目前，为了抑制上述影响，通常会在经颅磁刺激诱发脑电评估中，让被试或者患者带上耳塞，以减少噪声的影响。但是这种方式只能减弱噪声的干扰，在诱发神经响应信号中仍然会保留清晰的听觉诱发电位，因此无法屏蔽这种噪声的干扰。此外，实验研究也会采用一种外放噪声的方式用以减弱听觉噪声的影响。比如在被试或病人耳朵中通过入耳式耳机播放白噪声，或者采集线圈中产生的“滴滴”噪声，经过声音处理后再通过耳机回放给被试，这种方法可以有效屏蔽听觉诱发电位。但是，目前的技术通常是让被试或者患者自己调节音量以达到掩盖线圈噪声的大小。这种方式下存在很多弊端，第一由于听觉噪声音量与真实的大脑皮层听觉诱发电位没有明确一对一的对应关系，被试通过主观感受调节的音量大小可能过大或者过小，造成被试者感觉难受或者噪声屏蔽失败。第二由于这种方式需要被试者或者患者主动调节音量，这决定了这种方法在脑疾病临床患者中失效。因为很多脑损伤患者无法主动配合地去调节声音大小。At present, in order to suppress the above-mentioned effects, the subjects or patients are usually asked to wear earplugs during the evaluation of EEG induced by transcranial magnetic stimulation, so as to reduce the influence of noise. However, this method can only weaken the interference of noise, and still retain a clear auditory evoked potential in the evoked neural response signal, so it cannot shield the interference of this noise. In addition, the experimental research will also use a way of external noise to reduce the impact of auditory noise. For example, playing white noise through in-ear headphones in the ears of the subjects or patients, or collecting the "didi" noise generated in the coil, and then playing it back to the subjects through the earphones after sound processing, this method can effectively shield the auditory evoked potential. However, the current technology usually allows the subjects or patients to adjust the volume to cover the coil noise. There are many disadvantages in this method. First, because there is no clear one-to-one correspondence between the volume of auditory noise and the real auditory evoked potential of the cerebral cortex, the volume adjusted by the subject through subjective feeling may be too large or too small, causing the subject The patient feels uncomfortable or the noise shielding fails. Second, because this method requires the subject or patient to actively adjust the volume, this method is ineffective in clinical patients with brain diseases. Because many brain-damaged patients cannot actively and cooperatively adjust the volume of their voices.

综上，在经颅磁刺激治疗，现有掩蔽噪声的精度较低，且依赖于被试者或者患者的主动调节，导致经颅磁刺激治疗效果比较差。In summary, in the treatment of transcranial magnetic stimulation, the accuracy of masking noise is low, and it depends on the active adjustment of the subject or patient, resulting in poor therapeutic effect of transcranial magnetic stimulation.

其次，参阅图1，图1为本申请实施方式提供的一种颅磁刺激掩蔽噪声生成装置的硬件结构示意图。该颅磁刺激掩蔽噪声生成装置100包括至少一个处理器101，通信线路102，存储器103以及至少一个通信接口104。Next, refer to FIG. 1 . FIG. 1 is a schematic diagram of a hardware structure of a masking noise generation device for cranial magnetic stimulation provided in an embodiment of the present application. The cranial magnetic stimulation masking noise generator 100 includes at least one processor 101 , a communication line 102 , a memory 103 and at least one communication interface 104 .

在本实施方式中，处理器101，可以是一个通用中央处理器（central processingunit，CPU），微处理器，特定应用集成电路（application-specific integrated circuit，ASIC)，或一个或多个用于控制本申请方案程序执行的集成电路。In this embodiment, the processor 101 may be a general-purpose central processing unit (central processing unit, CPU), microprocessor, application-specific integrated circuit (application-specific integrated circuit, ASIC), or one or more This application programs the implementation of integrated circuits.

通信线路102，可以包括一通路，在上述组件之间传送信息。Communication line 102, which may include a path, transmits information between the aforementioned components.

通信接口104，可以是任何收发器一类的装置（如天线等），用于与其他设备或通信网络通信，例如以太网，RAN，无线局域网（wireless local area networks，WLAN）等。The communication interface 104 may be any device such as a transceiver (such as an antenna), and is used for communicating with other devices or communication networks, such as Ethernet, RAN, wireless local area networks (wireless local area networks, WLAN) and the like.

存储器103，可以是只读存储器（read-only memory，ROM)或可存储静态信息和指令的其他类型的静态存储设备，随机存取存储器（random access memory，RAM)或者可存储信息和指令的其他类型的动态存储设备，也可以是电可擦可编程只读存储器（electrically erasable programmable read-only memory，EEPROM）、只读光盘（compactdisc read-only memory，CD-ROM）或其他光盘存储、光碟存储（包括压缩光碟、激光碟、光碟、数字通用光碟、蓝光光碟等）、磁盘存储介质或者其他磁存储设备、或者能够用于携带或存储具有指令或数据结构形式的期望的程序代码并能够由计算机存取的任何其他介质，但不限于此。The memory 103 may be a read-only memory (read-only memory, ROM) or other types of static storage devices that can store static information and instructions, a random access memory (random access memory, RAM) or other types that can store information and instructions A type of dynamic storage device, it can also be an electrically erasable programmable read-only memory (EEPROM), a compact disc read-only memory (CD-ROM) or other optical disc storage, optical disc storage (including compact discs, laser discs, optical discs, digital versatile discs, Blu-ray discs, etc.), magnetic disk storage media or other magnetic storage devices, or can be used to carry or store desired program code in the form of instructions or data structures and can be programmed by a computer Any other medium accessed, but not limited to.

在本实施方式中，存储器103可以独立存在，通过通信线路102与处理器101相连接。存储器103也可以和处理器101集成在一起。本申请实施方式提供的存储器103通常可以具有非易失性。其中，存储器103用于存储执行本申请方案的计算机执行指令，并由处理器101来控制执行。处理器101用于执行存储器103中存储的计算机执行指令，从而实现本申请下述实施方式中提供的方法。In this embodiment, the memory 103 may exist independently and be connected to the processor 101 through the communication line 102 . The memory 103 can also be integrated with the processor 101 . The memory 103 provided in this embodiment of the present application may generally be non-volatile. Wherein, the memory 103 is used to store computer-executed instructions for implementing the solutions of the present application, and the execution is controlled by the processor 101 . The processor 101 is configured to execute computer-executed instructions stored in the memory 103, so as to implement the methods provided in the following embodiments of the present application.

在可选的实施方式中，计算机执行指令也可以称之为应用程序代码，本申请对此不作具体限定。In an optional implementation manner, computer-executed instructions may also be referred to as application code, which is not specifically limited in the present application.

在可选的实施方式中，处理器101可以包括一个或多个CPU，例如图1中的CPU0和CPU1。In an optional implementation manner, the processor 101 may include one or more CPUs, such as CPU0 and CPU1 in FIG. 1 .

在可选的实施方式中，该颅磁刺激掩蔽噪声生成装置100可以包括多个处理器，这些处理器中的每一个可以是一个单核（single-CPU）处理器，也可以是一个多核（multi-CPU）处理器。这里的处理器可以指一个或多个设备、电路、和/或用于处理数据（例如计算机程序指令）的处理核。In an optional embodiment, the TMS masking noise generating device 100 may include multiple processors, and each of these processors may be a single-core (single-CPU) processor, or a multi-core ( multi-CPU) processor. A processor herein may refer to one or more devices, circuits, and/or processing cores for processing data (eg, computer program instructions).

在可选的实施方式中，若颅磁刺激掩蔽噪声生成装置100为服务器，例如，可以是独立的服务器，也可以是提供云服务、云数据库、云计算、云函数、云存储、网络服务、云通信、中间件服务、域名服务、安全服务、内容分发网络(Content Delivery Network，CDN)、以及大数据和人工智能平台等基础云计算服务的云服务器。则颅磁刺激掩蔽噪声生成装置100还可以包括输出设备105和输入设备106。输出设备105和处理器101通信，可以以多种方式来显示信息。例如，输出设备105可以是液晶显示器（liquid crystal display，LCD），发光二级管（light emitting diode，LED)显示设备，阴极射线管（cathode ray tube，CRT）显示设备，或投影仪（projector）等。输入设备106和处理器101通信，可以以多种方式接收用户的输入。例如，输入设备106可以是鼠标、键盘、触摸屏设备或传感设备等。In an optional embodiment, if the cranial magnetic stimulation masking noise generating device 100 is a server, for example, it may be an independent server, or it may provide cloud services, cloud databases, cloud computing, cloud functions, cloud storage, network services, Cloud servers for basic cloud computing services such as cloud communications, middleware services, domain name services, security services, content delivery network (Content Delivery Network, CDN), and big data and artificial intelligence platforms. Then the TMS masking noise generator 100 may further include an output device 105 and an input device 106 . Output device 105 is in communication with processor 101 and may display information in a variety of ways. For example, the output device 105 may be a liquid crystal display (liquid crystal display, LCD), a light emitting diode (light emitting diode, LED) display device, a cathode ray tube (cathode ray tube, CRT) display device, or a projector (projector) wait. The input device 106 communicates with the processor 101 and can receive user input in various ways. For example, the input device 106 may be a mouse, a keyboard, a touch screen device, or a sensing device, among others.

上述的颅磁刺激掩蔽噪声生成装置100可以是一个通用设备或者是一个专用设备。本申请实施方式不限定颅磁刺激掩蔽噪声生成装置100的类型。The above-mentioned TMS masking noise generator 100 may be a general-purpose device or a special-purpose device. The embodiment of the present application does not limit the type of the masking noise generating device 100 for cranial magnetic stimulation.

最后，参阅图2，图2为本申请实施范式提供的一种颅磁刺激掩蔽噪声生成的场景示意图。Finally, please refer to FIG. 2 . FIG. 2 is a schematic diagram of a scene of generation of masking noise by cranial magnetic stimulation provided by the implementation paradigm of the present application.

如图2所示，在对受试者进行经颅磁刺激治疗之前，在受试者头部大脑的相应位置上放置线圈，耳中放置声音播放模块，例如入耳式耳机。然后，在声音播放模块播放掩蔽噪声的情况下，经颅磁刺激模块通过线圈对受试者进行多次经颅磁测试，得到目标掩蔽噪声，然后将目标掩蔽噪声作为受试者进行经颅磁刺激治疗时，使用的掩蔽噪声。其中，第i次经颅磁测试包括以下步骤内容：As shown in Figure 2, before the subject undergoes transcranial magnetic stimulation treatment, a coil is placed on the corresponding position of the subject's head and brain, and a sound playback module, such as an earphone, is placed in the ear. Then, when the sound playing module plays masking noise, the transcranial magnetic stimulation module conducts multiple transcranial magnetic tests on the subject through the coil to obtain the target masking noise, and then uses the target masking noise as the subject for transcranial magnetic testing. Masking noise used during stimulus treatment. Wherein, the i-th transcranial magnetic test includes the following steps:

播放掩蔽噪声A_i-1，采集多个线圈通道对应的多个第一声音信号，并对多个第一声音信号进行加工处理，得到第二声音信号B_i。同时，在多个线圈通道上采集与多个第一脉冲中每个第一脉冲对应的多个第一脑电信号，并对每个第一脉冲对应的多个第一脑电信号进行听觉诱发电位分析，得到听觉诱发电位判定结果C_i。其中，多个第一脑电信号与多个线圈通道一一对应，多个第一脑电信号的采集时段与多个第一声音信号的采集时段相同。然后，在听觉诱发电位判定结果C_i不满足预设条件时，根据听觉诱发电位判定结果C_i对第i-1次经颅磁测试的声音调制参数D_i-1进行调整，得到声音调制参数D_i，并基于声音调制参数D_i对第二声音信号B_i进行调制，得到第i+1次经颅磁测试的掩蔽噪声A_i，进行第i+1次经颅磁测试，直至满足预设条件，其中，当i=1时，声音调制参数D₁为预设参数；在听觉诱发电位判定结果C_i满足预设条件时，将掩蔽噪声A_i-1作为目标掩蔽噪声。Play the masking noise A_i-1 , collect multiple first sound signals corresponding to multiple coil channels, and process the multiple first sound signals to obtain a second sound signal B_i . At the same time, collecting multiple first EEG signals corresponding to each of the multiple first pulses on multiple coil channels, and performing auditory induction on the multiple first EEG signals corresponding to each first pulse Potential analysis to obtain auditory evoked potential judgment result C_i . Wherein, the multiple first EEG signals correspond to the multiple coil channels one by one, and the collection period of the multiple first EEG signals is the same as the collection period of the multiple first sound signals. Then, when the auditory evoked potential judgment result C_i does not meet the preset conditions, the sound modulation parameter D_i-1 of the i-1th transcranial magnetic test is adjusted according to the auditory evoked potential judgment result C_i to obtain the sound modulation parameter D_i , and modulate the second sound signal B_i based on the sound modulation parameter D_i to obtain the masking noise A_i of the i+1th transcranial magnetic test, and perform the i+1th transcranial magnetic test until the predetermined A condition is set, wherein, when i=1, the sound modulation parameter D₁ is a preset parameter; when the auditory evoked potential determination result C_i satisfies the preset condition, the masking noise A_i-1 is taken as the target masking noise.

以下，将对本申请所公开的一种颅磁刺激掩蔽噪声生成装置进行详细说明。Hereinafter, a device for generating masking noise for cranial magnetic stimulation disclosed in this application will be described in detail.

参阅图3，图3为本申请实施方式提供的一种颅磁刺激掩蔽噪声生成装置的示意图。该颅磁刺激掩蔽噪声生成装置可以包括：脑电采集模块、噪声采集模块、听觉诱发电位分析模块、噪声处理模块和声音调制模块。Referring to FIG. 3 , FIG. 3 is a schematic diagram of a masking noise generation device for cranial magnetic stimulation provided in an embodiment of the present application. The cranial magnetic stimulation masking noise generation device may include: an EEG acquisition module, a noise acquisition module, an auditory evoked potential analysis module, a noise processing module and a sound modulation module.

在本实施方式中，在进行第i次经颅磁测试中，播放由第i-1次经颅磁测试时生成的掩蔽噪声A_i-1。示例性的，在第2次经颅磁测试中，将对被试者播放第1次经颅磁测试时生成的掩蔽噪声A₁，而在第1次经颅磁测试中，由于没有前次测试，此时可以播放白噪声作为掩蔽噪声A₀，或者不播放噪声。In this embodiment, during the i-th transcranial magnetic test, the masking noise A i_-1 generated during the i-1 th transcranial magnetic test is played. Exemplarily, in the second transcranial magnetic test, the masking noise A₁ generated during the first transcranial magnetic test will be played to the subject, and in the first transcranial magnetic test, since there is no previous For testing, at this time, white noise can be played as masking noise A₀ , or no noise can be played.

在该情况下，噪声采集模块采集多个线圈通道对应的多个第一声音信号，同时，脑电采集模块在多个线圈通道上采集与多个第一脉冲中每个第一脉冲对应的多个第一脑电信号。具体而言，即多个第一脑电信号的采集时段与多个第一声音信号的采集时段相同，均为第i次经颅磁测试的时间段。In this case, the noise collection module collects multiple first sound signals corresponding to multiple coil channels, and at the same time, the EEG collection module collects multiple first sound signals corresponding to each of the multiple first pulses on multiple coil channels. first EEG signal. Specifically, the acquisition period of the plurality of first EEG signals is the same as the acquisition period of the plurality of first sound signals, both of which are the time period of the ith transcranial magnetic test.

在采集到多个第一声音信号后，噪声处理模块对该多个第一声音信号进行加工处理，得到第二声音信号B_i。示例性的，首先可以基于多个第一声音信号中的每个第一声音信号的幅值，对每个第一声音信号进行归一化处理，得到多个第三声音信号。然后，可以将多个第三声音信号随机串联，得到第四声音信号，并对第四声音信号的噪声频谱的相位进行随机打乱，并根据打乱后的噪声频谱重构出第五声音信号。最后，可以对第五声音信号进行多次重采样，得到多个第六声音信号，继而将多个第六声音信号叠加平均，得到第二声音信号B_i。After collecting a plurality of first sound signals, the noise processing module processes the plurality of first sound signals to obtain a second sound signal B_i . Exemplarily, first, based on the amplitude of each first sound signal among the plurality of first sound signals, normalization processing may be performed on each first sound signal to obtain a plurality of third sound signals. Then, a plurality of third sound signals can be randomly connected in series to obtain a fourth sound signal, and the phase of the noise spectrum of the fourth sound signal is randomly scrambled, and the fifth sound signal is reconstructed according to the scrambled noise spectrum . Finally, the fifth sound signal may be resampled multiple times to obtain multiple sixth sound signals, and then the multiple sixth sound signals are superimposed and averaged to obtain the second sound signal B_i .

具体而言，如图4所示，噪声采集模块会采集多个线圈通道对应的多个第一声音信号。故经颅磁刺激模块向受试者发放多个第一脉冲，例如：第一脉冲1、第一脉冲2、…第一脉冲n后，噪声采集模块会在多个线圈通道，例如：通道1、…通道m上，采集到与每个第一脉冲对应的多个第一声音信号，其中，多个线圈通道与多个第一声音信号一一对应。应理解，噪声采集模块在进行掩蔽噪声生成的整个过程中可以一直进行噪声信号的采集，然而本申请只需要研究发放脉冲前后，线圈噪声信号的变化情况。因此，该第一声音信号只是以发放每个第一脉冲时，导致线圈产生“嘀嘀”的时刻为基准，对噪声采集模块采集到的噪声信号进行信号截取所得到的。如图4所示，以第一脉冲1为例，将发放第一脉冲1导致线圈产生“嘀嘀”的时刻t1作为分界，将其前△t1时间段，以及其后△t2时间段的噪声信号截取出来，可得到每个第一脉冲在多个线圈通道上的多个第一声音信号。例如：△t1可以是线圈产生“嘀嘀”的时刻前10ms，△t2可以是线圈产生“嘀嘀”的时刻后50ms，本申请对此不做限制。Specifically, as shown in FIG. 4 , the noise collection module collects multiple first sound signals corresponding to multiple coil channels. Therefore, the transcranial magnetic stimulation module sends multiple first pulses to the subject, for example: after the first pulse 1, the first pulse 2, ... the first pulse n, the noise acquisition module will be in multiple coil channels, for example: channel 1 , ... on the channel m, a plurality of first sound signals corresponding to each first pulse is collected, wherein the plurality of coil channels correspond to the plurality of first sound signals one by one. It should be understood that the noise acquisition module can always collect noise signals during the whole process of masking noise generation, but this application only needs to study the change of the coil noise signal before and after the pulse is issued. Therefore, the first sound signal is obtained by intercepting the noise signal collected by the noise collection module based on the moment when each first pulse is issued, which causes the coil to generate a "beep". As shown in Figure 4, taking the first pulse 1 as an example, the time t1 when the first pulse 1 is issued to cause the coil to generate a "beep" is taken as the boundary, and the noise in the preceding △t1 time period and the subsequent △t2 time period The signal is intercepted to obtain multiple first sound signals of each first pulse on multiple coil channels. For example: △t1 may be 10 ms before the time when the coil generates "beep", and Δt2 may be 50 ms after the time when the coil generates "beep", which is not limited in this application.

基于此，在本实施方式中，可以基于每个第一声音信号的噪声幅值对每个第一声音信号进行归一化处理，得到多个第三声音信号。然后，按照时间伪随机的方式将每个第三声音信号重新随机串联，得到第四声音信号。示例性的，现有4个线圈，则对应有4个线圈通道以及4个归一化后得到的第三声音信号，分别记为：声音1、声音2、声音3和声音4。通过时间伪随机的方式，分别确定这4个第三声音信号的时间顺序，例如：声音1的时间顺序为2、声音2的时间顺序为3、声音3的时间顺序为1、声音4的时间顺序为4，则串联后的第四声音信号即为：声音3-声音1-声音2-声音4。Based on this, in this implementation manner, normalization processing may be performed on each first sound signal based on the noise amplitude of each first sound signal to obtain a plurality of third sound signals. Then, each third sound signal is rerandomly connected in series in a time-pseudo-random manner to obtain a fourth sound signal. Exemplarily, there are 4 coils, corresponding to 4 coil channels and 4 third sound signals obtained after normalization, which are recorded as sound 1, sound 2, sound 3 and sound 4 respectively. The time order of the four third sound signals is determined respectively in a time pseudo-random manner, for example: the time order of sound 1 is 2, the time order of sound 2 is 3, the time order of sound 3 is 1, and the time of sound 4 If the sequence is 4, the fourth sound signal after series connection is: sound 3-sound 1-sound 2-sound 4.

然后，可以对重新串联的第四声音信号的时序信号进行傅里叶频谱分析，提取第一时间序列相位，并按照伪随机方法打乱第一时间序列相位的相位，得到第二时间序列相位。继而基于第二时间序列相位重构出对应时间序列的第五声音信号。Then, Fourier spectrum analysis can be performed on the time series signal of the reconnected fourth sound signal, the first time series phase is extracted, and the phase of the first time series phase is disturbed according to a pseudo-random method to obtain the second time series phase. Then, based on the phase of the second time series, the fifth sound signal corresponding to the time series is reconstructed.

最后，可以对第五声音信号进行多次重采样，得到多个第六声音信号，继而将多个第六声音信号叠加平均得到消除噪声信号的节律特征的第二声音信号B_i。示例性的，重采样的采样率可以是原采样率±10、20、30、40、50Hz等。Finally, the fifth sound signal may be resampled multiple times to obtain a plurality of sixth sound signals, and then the plurality of sixth sound signals are superimposed and averaged to obtain a second sound signal_Bi that eliminates the rhythm feature of the noise signal. Exemplarily, the sampling rate of the resampling may be ±10, 20, 30, 40, 50 Hz, etc. of the original sampling rate.

在本实施方式中，在对多个第一声音信号进行加工处理的同时，听觉诱发电位分析模块对每个第一脉冲对应的多个第一脑电信号进行听觉诱发电位分析，得到听觉诱发电位判定结果C_i。In this embodiment, while processing the multiple first sound signals, the auditory evoked potential analysis module performs auditory evoked potential analysis on the multiple first EEG signals corresponding to each first pulse to obtain the auditory evoked potential Judgment result C_i .

具体而言，与上述第一声音信号相似，脑电采集模块会在多线圈通道上进行脑电信号采集。故经颅磁刺激模块向受试者发放多个第一脉冲后，脑电采集模块会在多个线圈通道上采集到与每个第一脉冲对应的多个第一脑电信号，其中，多个线圈通道与多个第一脑电信号一一对应。应理解，脑电采集模块在进行掩蔽噪声生成的整个过程中可以一直进行脑电信号的采集，然而本申请只需要研究发放脉冲前后，受试者的脑电信号变化情况。因此，该第一脑电信号只是以发放每个第一脉冲的时刻为基准，对脑电采集模块采集到的脑电信号进行信号截取所得到的。由此，将发放每个第一脉冲引起脑电响应信号幅值的峰值为基准，截取该峰值前△t3时间段，以及后△t4时间段的脑电信号，即可得到每个第一脉冲在多个线圈通道上的多个第一脑电信号。例如：△t3可以是峰值前300ms，△t4可以是峰值后500ms，本申请对此不做限制。Specifically, similar to the above-mentioned first sound signal, the EEG acquisition module will collect EEG signals on a multi-coil channel. Therefore, after the transcranial magnetic stimulation module sends multiple first pulses to the subject, the EEG acquisition module will collect multiple first EEG signals corresponding to each first pulse on multiple coil channels, among which, multiple Each coil channel is in one-to-one correspondence with a plurality of first EEG signals. It should be understood that the EEG acquisition module can always collect EEG signals during the whole process of masking noise generation. However, this application only needs to study the changes of the EEG signals of the subject before and after pulses are issued. Therefore, the first EEG signal is obtained by intercepting the EEG signal collected by the EEG acquisition module based on the time when each first pulse is issued. Thus, taking the peak value of the amplitude of the EEG response signal caused by each first pulse as a reference, and intercepting the EEG signal in the time period Δt3 before and after the time period Δt4, each first pulse can be obtained Multiple first EEG signals on multiple coil channels. For example: Δt3 may be 300ms before the peak value, and Δt4 may be 500ms after the peak value, which is not limited in this application.

基于此，在本实施方式中，首先，可以对多个第一脑电信号中的每个第一脑电信号进行噪声去除处理，得到与多个第一脑电信号一一对应的多个第二脑电信号。具体而言，听觉诱发电位分析模块基于发放每个第一脉冲的时刻，分别对多个第一脑电信号进行插值，得到与多个第一脑电信号一一对应的多个第三脑电信号。具体而言，利用插值算法，分别对每个第一脉冲在每个通道上的第一脑电信号的前△t5时间段内的脑电信号进行插值，以及对后△t6时间段的脑电信号进行插值，得到多个第三脑电信号。例如：△t5可以是脉冲前3ms，△t6可以是脉冲后20ms，本申请对此不做限制。Based on this, in this embodiment, firstly, noise removal processing may be performed on each of the multiple first EEG signals to obtain multiple first EEG signals corresponding to the multiple first EEG signals one-to-one. Two EEG signals. Specifically, the auditory evoked potential analysis module interpolates the multiple first EEG signals based on the moment when each first pulse is issued to obtain multiple third EEG signals corresponding to the multiple first EEG signals. Signal. Specifically, the interpolation algorithm is used to interpolate the EEG signals in the first Δt5 time period of the first EEG signal on each channel for each first pulse, and to interpolate the EEG signals in the subsequent Δt6 time period. The signal is interpolated to obtain multiple third EEG signals. For example: Δt5 may be 3 ms before the pulse, and Δt6 may be 20 ms after the pulse, which is not limited in this application.

然后，针对每个第三脑电信号，获取该第三脑电信号在预设时间段内的幅值的均值。比如，该预设时间段为发放该第一脉冲的时刻的前△t3时间段。然后，将该第三脑电信号在各个时刻下的幅值减去均值，得到与该第三脑电信号对应的第四脑电信号，即对第三脑电信号进行基线校正，得到与该第三脑电信号对应的第四脑电信号，进而得到每个第一脉冲在多个通道上的多个第四脑电信号。Then, for each third electroencephalogram signal, an average value of the amplitude of the third electroencephalogram signal within a preset time period is obtained. For example, the preset time period is a time period Δt3 before the moment when the first pulse is issued. Then, subtract the mean value from the amplitude of the third EEG signal at each moment to obtain a fourth EEG signal corresponding to the third EEG signal, that is, perform baseline correction on the third EEG signal to obtain a corresponding EEG signal. The fourth electroencephalogram signal corresponding to the third electroencephalogram signal, and then obtain multiple fourth electroencephalogram signals on multiple channels for each first pulse.

然后，对该多个第四脑电信号进行带通滤波，得到多个第五脑电信号，以将所有数据带通滤波到1-45Hz。Then, perform band-pass filtering on the plurality of fourth EEG signals to obtain a plurality of fifth EEG signals, so as to band-pass filter all data to 1-45 Hz.

然后，对多个第五脑电信号进行坏通道替换和坏数据段剔除，得到多个第六脑电信号。需要说明的是，在本实施方式中，每次经颅磁测试的过程将向多个线圈通道发放多次脉冲，继而在每个线圈通道中，将产生与该多次脉冲对应的多个第一脑电信号，即每个线圈通道对应有多个第一脑电信号。基于此，以下将以数据段代指经过上述各项处理后的第一脑电信号，即第五脑电信号，对该坏通道替换和坏数据段剔除进行详细说明。Then, performing bad channel replacement and bad data segment elimination on the multiple fifth EEG signals to obtain multiple sixth EEG signals. It should be noted that, in this embodiment, multiple pulses will be issued to multiple coil channels during each transcranial magnetic test, and then multiple pulses corresponding to the multiple pulses will be generated in each coil channel. An EEG signal, that is, each coil channel corresponds to a plurality of first EEG signals. Based on this, below, the data segment will be used to refer to the first EEG signal after the above-mentioned processing, that is, the fifth EEG signal, and the bad channel replacement and bad data segment removal will be described in detail.

具体而言，首先分别计算每个线圈通道对应的所有数据段信号的功率谱，继而计算1-30Hz频段的功率谱总能量。将每个线圈通道的功率谱总能量的平均值的标准差作为基准值，将功率谱总能量大于3.5个标准差或小于-5个标准差的线圈通道标记为坏通道并通过三次方球形差值数据替换掉。在进行三次方球形差值计算时，将被标记为坏通道的线圈通道物理位置上直接相邻的线圈通道的所有数据段作为输入数据，计算对应的替换数据对坏通道的数据进行替换。然后，对每个数据段内所有线圈通道，计算1-30Hz频段的功率谱总能量，并针对每个线圈通道，计算线圈通道在所有数据段内功率谱总能量。若当前数据段的功率谱总能量大于所有数据段的功率谱总能量的平均值3.5个标准差或小于-5个标准差，则判定当前数据段为坏数据，对其进行剔除。最后，将进行坏通道替换和坏数据段剔除后的数据那行对应整理，即可得到多个第六脑电信号。Specifically, first calculate the power spectrum of all data segment signals corresponding to each coil channel, and then calculate the total energy of the power spectrum in the 1-30 Hz frequency band. The standard deviation of the average value of the total energy of the power spectrum of each coil channel is used as the reference value, and the coil channel with the total energy of the power spectrum greater than 3.5 standard deviations or less than -5 standard deviations is marked as a bad channel and passed through the cubic spherical difference Value data replaced. When calculating the cubic spherical difference, all the data segments of the coil channel directly adjacent to the coil channel marked as bad channel at the physical position are used as input data, and the corresponding replacement data is calculated to replace the data of the bad channel. Then, for all coil channels in each data segment, calculate the total energy of the power spectrum in the 1-30Hz frequency band, and for each coil channel, calculate the total energy of the power spectrum of the coil channel in all data segments. If the total energy of the power spectrum of the current data segment is greater than 3.5 standard deviations or less than -5 standard deviations of the average value of the total energy of the power spectrum of all data segments, the current data segment is determined to be bad data and eliminated. Finally, the rows of data after bad channel replacement and bad data segment removal are arranged correspondingly, and multiple sixth EEG signals can be obtained.

最后，对多个第六脑电信号进行独立成分分析，得到多个第二脑电信号。具体而言，可以使用ARTIST数据库中提供的经颅磁刺激诱发脑电噪声独立成分识别方法，对多个第六脑电信号进行独立成分分析，继而得到去除噪声的多个第二脑电信号。Finally, independent component analysis is performed on the multiple sixth EEG signals to obtain multiple second EEG signals. Specifically, the method for identifying independent components of EEG noise induced by transcranial magnetic stimulation provided in the ARTIST database can be used to perform independent component analysis on multiple sixth EEG signals, and then obtain multiple second EEG signals with noise removed.

在本实施方式中，得到多个第二脑电信号后，基于发放每个第一脉冲的时刻，对多个第二脑电信号中的每个第二脑电信号进行截取，得到多个第一信号片段和多个第二信号片段，其中，多个第一信号片段与多个第二脑电信号一一对应，多个第二信号片段与多个第二脑电信号一一对应。具体而言，可以提取发放每个第一脉冲的时刻后△t7时间段内的信号作为第一信号片段，提取发放每个第一脉冲的时刻后△t8时间段内的信号作为第二信号片段。例如：△t7可以是脉冲后90-110ms，△t8可以是脉冲后180-220ms，本申请对此不做限制。In this embodiment, after obtaining a plurality of second EEG signals, each second EEG signal in the plurality of second EEG signals is intercepted based on the time when each first pulse is issued to obtain a plurality of second EEG signals. A signal segment and multiple second signal segments, wherein the multiple first signal segments correspond to the multiple second EEG signals one-to-one, and the multiple second signal segments correspond to the multiple second EEG signals one-to-one. Specifically, the signal within the Δt7 time period after each first pulse can be extracted as the first signal segment, and the signal within the Δt8 time period after each first pulse can be extracted as the second signal segment . For example: Δt7 may be 90-110 ms after the pulse, and Δt8 may be 180-220 ms after the pulse, which is not limited in this application.

然后，如图5所示，基于多个第一信号片段，确定第i次经颅磁测试中的听觉诱发成份N100。基于多个第二信号片段，确定第i次经颅磁测试中的诱发成份P200。并根据听觉诱发成份N100的幅值，与诱发成份P200的幅值，确定听觉诱发电位判定结果C_i。具体而言，以发放每个第一脉冲的时刻为分割线，对每个第一脉冲在每个通道上的第二脑电信号进行信号分割，得到每个第一脉冲在每个通道上的基线信号。基于利用Bootstrap分析，对每个第一脉冲在每个通道上的基线信号的幅值进行高斯拟合，并以置信度p=0.05确定幅值阈值。继而，当听觉诱发成份N100的幅值高于或等于幅值阈值，或者诱发成份P200的幅值高于或等于幅值阈值，则判定听觉诱发电位判定结果C_i为存在听觉诱发电位，否则，判定听觉诱发电位判定结果C_i为没有听觉诱发电位。此外，可以存储N100和P200的幅值，并与历史幅值对比，评估当前掩蔽噪声对听觉诱发电位的影响。Then, as shown in FIG. 5 , based on the plurality of first signal segments, the auditory evoked component N100 in the ith transcranial magnetic test is determined. Based on the plurality of second signal segments, the evoked component P200 in the i-th transcranial magnetic test is determined. And according to the amplitude of the auditory evoked component N100 and the amplitude of the evoked component P200, the auditory evoked potential judgment result C_i is determined. Specifically, taking the time when each first pulse is issued as the dividing line, the second EEG signal of each first pulse on each channel is signal-divided, and the second EEG signal of each first pulse on each channel is obtained. baseline signal. Based on analysis using Bootstrap, a Gaussian fit was performed to the amplitude of the baseline signal on each channel for each first pulse, and an amplitude threshold was determined with a confidence level of p=0.05. Then, when the amplitude of the auditory evoked component N100 is higher than or equal to the amplitude threshold, or the amplitude of the evoked component P200 is higher than or equal to the amplitude threshold, it is determined that the auditory evoked potential determination result Ci_is that there is an auditory evoked potential, otherwise, The auditory evoked potential determination result C_i is determined to be no auditory evoked potential. In addition, the amplitudes of N100 and P200 can be stored and compared with historical amplitudes to evaluate the impact of current masking noise on auditory evoked potentials.

在本实施方式中，确定听觉诱发电位判定结果C_i后，声音调制模块可以根据该听觉诱发电位判定结果C_i确定目标掩蔽噪声。示例性的，当听觉诱发电位判定结果C_i不满足预设条件，即听觉诱发电位判定结果C_i为存在听觉诱发电位时，根据听觉诱发电位判定结果C_i对第i-1次经颅磁测试的声音调制参数D_i-1进行调整，得到声音调制参数D_i，并基于声音调制参数D_i对第二声音信号B_i进行调制，得到第i+1次经颅磁测试的掩蔽噪声A_i，进行第i+1次经颅磁测试，直至满足预设条件。In this embodiment, after the auditory evoked potential determination result C_i is determined, the sound modulation module may determine the target masking noise according to the auditory evoked potential determination result C_i . Exemplarily, when the auditory evoked potential determination result C_i does not meet the preset condition, that is, when the auditory evoked potential determination result C i indicates that there is an auditory evoked potential, according to the auditory evoked potential determination result_{C i}_, the i-1 transcranial magnetic The sound modulation parameter D_i-1 of the test is adjusted to obtain the sound modulation parameter D_i , and the second sound signal B_i is modulated based on the sound modulation parameter D_i to obtain the masking noise A of the i+1 transcranial magnetic test_i , perform the i+1th transcranial magnetic test until the preset condition is met.

具体而言，在第1次经颅磁测试中，即i=1时，声音调制参数D₀为空，而声音调制参数D₁为预设参数。在之后的每次经颅磁测试中，则可以基于预设的步进单位对声音调制参数D_i-1中的每个参数或部分参数进行步进调整，得到声音调制参数D_i。示例性的，声音调制参数可以包括混合噪声比例和音量。其中，混合噪声比例用于调节白噪声与第二声音信号B_i之间的混合比例（白噪声比第二声音信号B_i），其范围可以为0.1-0.5，步进单位为0.1。音量用于调节混合后的掩蔽噪声的音量，其范围可以为60dB-100dB，步进单位为10dB。基于此，在第1次经颅磁测试中，声音调制参数D₀为空，此时，若听觉诱发电位判定结果C_i不满足预设条件，则设定声音调制参数D₁中，混合噪声比例为0.1，音量为60dB。并在之后的经颅磁测试中，每次调节对混合噪声比例和/或音量进行步进单位的增加，得到调整后的声音调制参数。例如：第2次经颅磁测试中，若听觉诱发电位判定结果C_i不满足预设条件，则可以存在以下3种调节方式：Specifically, in the first transcranial magnetic test, that is, when i=1, the sound modulation parameter D₀ is empty, and the sound modulation parameter D₁ is a preset parameter. In each subsequent transcranial magnetic test, each parameter or some of the parameters in the sound modulation parameter D_i-1 can be adjusted step by step based on a preset step unit to obtain the sound modulation parameter D_i . Exemplarily, the sound modulation parameters may include mixing noise ratio and volume. Wherein, the mixing noise ratio is used to adjust the mixing ratio between the white noise and the second sound signal B_i (white noise ratio to the second sound signal B_i ), and its range may be 0.1-0.5, and the step unit is 0.1. Volume is used to adjust the volume of the mixed masking noise, and its range can be 60dB-100dB, and the step unit is 10dB. Based on this, in the first transcranial magnetic test, the sound modulation parameter D₀ is empty. At this time, if the auditory evoked potential judgment result C_i does not meet the preset conditions, set the sound modulation parameter D₁ , mixed noise The scale is 0.1 and the volume is 60dB. And in the subsequent transcranial magnetic test, each adjustment increases the mixed noise ratio and/or volume by a step unit to obtain the adjusted sound modulation parameters. For example: in the second transcranial magnetic test, if the auditory evoked potential judgment result C_i does not meet the preset conditions, there may be the following three adjustment methods:

（1）混合噪声比例增加步进单位量，音量保持不变，即混合噪声比例为0.2，音量为60dB。(1) The mixed noise ratio increases by the step unit, and the volume remains unchanged, that is, the mixed noise ratio is 0.2, and the volume is 60dB.

（2）混合噪声比例保持不变，音量增加步进单位量，即混合噪声比例为0.1，音量为70dB。(2) The mixed noise ratio remains unchanged, and the volume is increased by a step unit, that is, the mixed noise ratio is 0.1, and the volume is 70dB.

（3）混合噪声比例和音量均增加步进单位量，即混合噪声比例为0.2，音量为70dB。(3) Both the mixed noise ratio and the volume increase by the step unit amount, that is, the mixed noise ratio is 0.2, and the volume is 70dB.

在本实施方式中，可以任选其中一种方式进行参数调整，本申请对此不做限制。In this implementation manner, one of the modes may be selected for parameter adjustment, which is not limited in the present application.

在本实施方式中，掩蔽噪声的调制过程，即为将白噪声比第二声音信号B_i按照混合噪声比例进行混合叠加，并将叠加后的噪声的音量调节为音量参数的数值。其中，白噪声为使用归一化随机频率的噪声，由此，如图6所示，进行叠加后，将产生一种频谱与线圈噪声相近的混合噪声，继而可以有效对线圈的噪声进行抑制。In this embodiment, the noise masking modulation process is to mix and superimpose the white noise and the second sound signal B_i according to the mixed noise ratio, and adjust the volume of the superimposed noise to the value of the volume parameter. Among them, the white noise is the noise using normalized random frequency. Therefore, as shown in Figure 6, after superposition, a mixed noise with a spectrum similar to the coil noise will be generated, and then the coil noise can be effectively suppressed.

在本实施方式中，当听觉诱发电位判定结果C_i满足预设条件，即听觉诱发电位判定结果Ci为没有听觉诱发电位时，则可以直接将掩蔽噪声A_i-1作为目标掩蔽噪声。In this embodiment, when the auditory evoked potential determination result C_i satisfies the preset condition, that is, when the auditory evoked potential determination result Ci is no auditory evoked potential, the masking noise A_i-1 can be directly used as the target masking noise.

在本实施方式中，确定目标掩蔽噪声后，可以以该目标掩蔽噪声为后续经颅磁刺激治疗中使用的掩蔽噪声，如图7所示，使用上述方法得到的目标掩蔽噪声后，受试者脑电信号中的N100和P200得到了明显的抑制，继而消除经颅磁刺激线圈噪声对诱发神经响应的影响。In this embodiment, after the target masking noise is determined, the target masking noise can be used as the masking noise used in the subsequent transcranial magnetic stimulation treatment. As shown in Figure 7, after using the target masking noise obtained by the above method, the subject N100 and P200 in EEG signals were significantly suppressed, which in turn eliminated the effect of TMS coil noise on evoked neural responses.

综上所述，本发明所提供的颅磁刺激掩蔽噪声生成方法中，通过对经颅磁诱发听觉电位进行检测，确定听觉诱发电位判定结果C_i，继而基于该判定结果对由多个线圈通道对应的多个第一声音信号加工得到的第二声音信号B_i进行调制，得到目标掩蔽噪声，以消除经颅磁刺激线圈噪声对诱发神经响应的影响。由此，通过自动闭环反馈式调节的方式，适配个体化适应，继而无需被试者或病人主动调节，即可实现个体化的精准掩蔽噪声的自动化生成。从而克服了现行方案中需要被试或病人主动调节噪声音量或噪声掩蔽效果不佳的缺陷，排除经颅磁刺激诱发脑电在脑评估中的人为主观影响。此外，本申请实施方式不依赖被试者或病人的操作，使得对经颅磁刺激线圈噪声的掩蔽能够适用于一些丧失主动行为能力的病人，从而保障了经颅磁刺激诱发神经反应评估能够运用于临床重症病人。To sum up, in the method for generating masking noise for cranial magnetic stimulation provided by the present invention, the auditory evoked potential judgment result C_i is determined by detecting the transcranial magnetically evoked auditory potential, and then based on the judgment result, the multiple coil channels The second sound signal B_i obtained by processing the corresponding plurality of first sound signals is modulated to obtain target masking noise, so as to eliminate the influence of the noise of the transcranial magnetic stimulation coil on the evoked nerve response. Therefore, through the automatic closed-loop feedback adjustment method, the individualized adaptation can be adapted, and then the automatic generation of individualized and accurate masking noise can be realized without active adjustment by the subject or patient. In this way, it overcomes the defect that the subject or patient actively adjusts the noise volume or the noise masking effect is not good in the current scheme, and excludes the artificial subjective influence of the EEG induced by transcranial magnetic stimulation in the brain evaluation. In addition, the embodiment of the present application does not rely on the operation of the subject or the patient, so that the masking of the noise of the transcranial magnetic stimulation coil can be applied to some patients who have lost their active behavior, thus ensuring that the evaluation of the neural response induced by transcranial magnetic stimulation can be used in clinical critically ill patients.

参阅图8，图8为本申请实施方式提供的一种颅磁刺激掩蔽噪声生成方法的流程示意图。如图8所示，该颅磁刺激掩蔽噪声生成方法包括但不限于以下步骤内容：Referring to FIG. 8 , FIG. 8 is a schematic flowchart of a method for generating masking noise for cranial magnetic stimulation provided in an embodiment of the present application. As shown in Fig. 8, the method for generating masking noise by cranial magnetic stimulation includes but is not limited to the following steps:

S801：在第i次经颅磁测试中，播放掩蔽噪声A_i-1的情况下，采集多个线圈通道对应的多个第一声音信号。S801: In the i-th transcranial magnetic test, in the case of playing masking noise A_i-1 , collect multiple first sound signals corresponding to multiple coil channels.

在本实施方式中，i为大于或等于1的整数，掩蔽噪声A_i-1由第i-1次经颅磁测试确定；In this embodiment, i is an integer greater than or equal to 1, and the masking noise A_i-1 is determined by the i-1th transcranial magnetic test;

S802：对多个第一声音信号进行加工处理，得到第二声音信号B_i。S802: Process a plurality of first sound signals to obtain a second sound signal B_i .

S803：在多个线圈通道上采集与多个第一脉冲中每个第一脉冲对应的多个第一脑电信号。S803: Acquire multiple first EEG signals corresponding to each first pulse in multiple first pulses on multiple coil channels.

在本实施方式中，多个第一脑电信号与多个线圈通道一一对应，多个第一脑电信号的采集时段与多个第一声音信号的采集时段相同；In this embodiment, the plurality of first EEG signals correspond to the plurality of coil channels one by one, and the acquisition period of the plurality of first EEG signals is the same as the acquisition period of the plurality of first sound signals;

S804：对每个第一脉冲对应的多个第一脑电信号进行听觉诱发电位分析，得到听觉诱发电位判定结果C_i。S804: Perform auditory evoked potential analysis on multiple first EEG signals corresponding to each first pulse to obtain an auditory evoked potential determination result C_i .

S805：在听觉诱发电位判定结果C_i不满足预设条件时，根据听觉诱发电位判定结果C_i对第i-1次经颅磁测试的声音调制参数D_i-1进行调整，得到声音调制参数D_i，并基于声音调制参数D_i对第二声音信号B_i进行调制，得到第i+1次经颅磁测试的掩蔽噪声A_i，进行第i+1次经颅磁测试，直至满足预设条件。S805: When the auditory evoked potential determination result C_i does not meet the preset condition, adjust the sound modulation parameter D_i-1 of the i-1 transcranial magnetic test according to the auditory evoked potential determination result C_i to obtain the sound modulation parameter D_i , and modulate the second sound signal B_i based on the sound modulation parameter D_i to obtain the masking noise A_i of the i+1th transcranial magnetic test, and perform the i+1th transcranial magnetic test until the predetermined set conditions.

在本实施方式中，当i=1时，声音调制参数D₁为预设参数；In this embodiment, when i=1, the sound modulation parameter_D1 is a preset parameter;

S806：在听觉诱发电位判定结果C_i满足预设条件时，将掩蔽噪声A_i-1作为目标掩蔽噪声。S806: When the auditory evoked potential determination result C_i satisfies the preset condition, use the masking noise A_i-1 as the target masking noise.

其中，步骤S801~步骤S806的具体实现过程，可参照上述脑电采集模块、噪声采集模块、听觉诱发电位分析模块、噪声处理模块和声音调制模块的具体功能，在此不再赘述。Wherein, the specific implementation process of steps S801 to S806 can refer to the specific functions of the above-mentioned EEG acquisition module, noise acquisition module, auditory evoked potential analysis module, noise processing module and sound modulation module, and will not be repeated here.

参阅图9，图9为本申请实施方式提供的一种电子设备的结构示意图。如图9所示，电子设备900包括收发器901、处理单元902和储存器903。它们之间通过总线904连接。储存器903用于存储计算机程序和数据，并可以将储存器903存储的数据传输给处理单元902。Referring to FIG. 9 , FIG. 9 is a schematic structural diagram of an electronic device provided in an embodiment of the present application. As shown in FIG. 9 , an electronic device 900 includes a transceiver 901 , a processing unit 902 and a storage 903 . They are connected through a bus 904 . The storage 903 is used to store computer programs and data, and can transmit the data stored in the storage 903 to the processing unit 902 .

处理单元902用于读取储存器903中的计算机程序执行以下操作：The processing unit 902 is used to read the computer program in the storage 903 to perform the following operations:

在第i次经颅磁测试中，播放掩蔽噪声A_i-1的情况下，采集多个线圈通道对应的多个第一声音信号，其中，i为大于或等于1的整数，掩蔽噪声A_i-1由第i-1次经颅磁测试确定；In the i-th transcranial magnetic test, when the masking noise A_i-1 is played, multiple first sound signals corresponding to multiple coil channels are collected, where i is an integer greater than or equal to 1, and the masking noise A_{i -1} determined by the i-1th transcranial magnetic test;

对多个第一声音信号进行加工处理，得到第二声音信号B_i；Processing a plurality of first sound signals to obtain a second sound signal B_i ;

在多个线圈通道上采集与多个第一脉冲中每个第一脉冲对应的多个第一脑电信号，其中，多个第一脑电信号与多个线圈通道一一对应，多个第一脑电信号的采集时段与多个第一声音信号的采集时段相同；A plurality of first electroencephalogram signals corresponding to each first pulse in the plurality of first pulses is collected on a plurality of coil channels, wherein the plurality of first electroencephalogram signals correspond to the plurality of coil channels one by one, and the plurality of first electroencephalogram signals correspond to the plurality of coil channels one by one, and the plurality of first electroencephalogram signals The acquisition period of an EEG signal is the same as the acquisition periods of the plurality of first sound signals;

对每个第一脉冲对应的多个第一脑电信号进行听觉诱发电位分析，得到听觉诱发电位判定结果C_i；Performing auditory evoked potential analysis on multiple first EEG signals corresponding to each first pulse to obtain an auditory evoked potential determination result C_i ;

在听觉诱发电位判定结果C_i不满足预设条件时，根据听觉诱发电位判定结果C_i对第i-1次经颅磁测试的声音调制参数D_i-1进行调整，得到声音调制参数D_i，并基于声音调制参数D_i对第二声音信号B_i进行调制，得到第i+1次经颅磁测试的掩蔽噪声A_i，进行第i+1次经颅磁测试，直至满足预设条件，其中，当i=1时，声音调制参数D₁为预设参数；When the auditory evoked potential judgment result C_i does not meet the preset conditions, adjust the sound modulation parameter D_i-1 of the i-1 transcranial magnetic test according to the auditory evoked potential judgment result C_i to obtain the sound modulation parameter D_i , and modulate the second sound signal B_i based on the sound modulation parameter D_i to obtain the masking noise A_i of the i+1th transcranial magnetic test, and perform the i+1th transcranial magnetic test until the preset conditions are met , wherein, when i=1, the sound modulation parameter_D1 is a preset parameter;

在听觉诱发电位判定结果C_i满足预设条件时，将掩蔽噪声A_i-1作为目标掩蔽噪声。When the auditory evoked potential determination result C_i satisfies the preset condition, the masking noise A_i-1 is taken as the target masking noise.

在本发明的实施方式中，在对多个第一声音信号进行加工处理，得到第二声音信号B_i方面，处理单元902，具体用于执行以下步骤：In an embodiment of the present invention, in terms of processing a plurality of first sound signals to obtain a second sound signal_Bi , the processing unit 902 is specifically configured to perform the following steps:

在本发明的实施方式中，在对第四声音信号的噪声频谱的相位进行随机打乱，并根据打乱后的噪声频谱重构出第五声音信号方面，处理单元902，具体用于执行以下步骤：In an embodiment of the present invention, in terms of random scrambling the phase of the noise spectrum of the fourth sound signal, and reconstructing the fifth sound signal according to the scrambled noise spectrum, the processing unit 902 is specifically configured to perform the following step:

在本发明的实施方式中，在对每个第一脉冲对应的多个第一脑电信号进行听觉诱发电位分析，得到听觉诱发电位判定结果C_i方面，处理单元902，具体用于执行以下步骤：In an embodiment of the present invention, in terms of performing auditory evoked potential analysis on multiple first EEG signals corresponding to each first pulse to obtain the auditory evoked potential determination result_Ci , the processing unit 902 is specifically configured to perform the following steps :

在本发明的实施方式中，在对多个第一脑电信号中的每个第一脑电信号进行噪声去除处理，得到多个第二脑电信号方面，处理单元902，具体用于执行以下步骤：In an embodiment of the present invention, in terms of performing noise removal processing on each of the multiple first EEG signals to obtain multiple second EEG signals, the processing unit 902 is specifically configured to perform the following step:

在本发明的实施方式中，在根据听觉诱发成份的幅值，与诱发成份的幅值，确定听觉诱发电位判定结果C_i方面，处理单元902，具体用于执行以下步骤：In an embodiment of the present invention, in terms of determining the auditory evoked potential determination result_Ci according to the amplitude of the auditory evoked component and the amplitude of the evoked component, the processing unit 902 is specifically configured to perform the following steps:

在本发明的实施方式中，在根据听觉诱发电位判定结果C_i对第i-1次经颅磁测试的声音调制参数D_i-1进行调整，得到声音调制参数D_i方面，处理单元902，具体用于执行以下步骤：In an embodiment of the present invention, in terms of adjusting the sound modulation parameter D_i-1 of the i-1th transcranial magnetic test according to the auditory evoked potential determination result C_i to obtain the sound modulation parameter D_i , the processing unit 902, Specifically used to perform the following steps:

应理解，本申请中的颅磁刺激掩蔽噪声生成装置可以包括智能手机（如Android手机、iOS手机、Windows Phone手机等）、平板电脑、掌上电脑、笔记本电脑、移动互联网设备MID（Mobile Internet Devices，简称：MID）、机器人或穿戴式设备等。上述颅磁刺激掩蔽噪声生成装置仅是举例，而非穷举，包含但不限于上述颅磁刺激掩蔽噪声生成装置。在实际应用中，上述颅磁刺激掩蔽噪声生成装置还可以包括：智能车载终端、计算机设备等等。It should be understood that the TMS masking noise generation device in this application may include smart phones (such as Android phones, iOS phones, Windows Phone phones, etc.), tablet computers, palmtop computers, notebook computers, mobile Internet devices MID (Mobile Internet Devices, Abbreviation: MID), robots or wearable devices, etc. The above-mentioned cranial magnetic stimulation masking noise generation device is only an example, not exhaustive, including but not limited to the above-mentioned cranial magnetic stimulation masking noise generation device. In practical applications, the above-mentioned device for generating masking noise for cranial magnetic stimulation may also include: an intelligent vehicle-mounted terminal, computer equipment, and the like.

通过以上的实施方式的描述，本领域的技术人员可以清楚地了解到本发明可借助软件结合硬件平台的方式来实现。基于这样的理解，本发明的技术方案对背景技术做出贡献的全部或者部分可以以软件产品的形式体现出来，该计算机软件产品可以存储在存储介质中，如ROM/RAM、磁碟、光盘等，包括若干指令用以使得一台计算机设备（可以是个人计算机，服务器，或者网络设备等）执行本发明各个实施方式或者实施方式的某些部分所述的方法。Through the above description of the implementation manners, those skilled in the art can clearly understand that the present invention can be implemented by combining software with a hardware platform. Based on this understanding, all or part of the contribution made by the technical solution of the present invention to the background technology can be embodied in the form of software products, and the computer software products can be stored in storage media, such as ROM/RAM, magnetic disks, optical disks, etc. , including several instructions to make a computer device (which may be a personal computer, a server, or a network device, etc.) execute the methods described in various embodiments or some parts of the embodiments of the present invention.

因此，本申请实施方式还提供一种计算机可读存储介质，所述计算机可读存储介质存储有计算机程序，所述计算机程序被处理器执行以实现如上述方法实施方式中记载的任何一种颅磁刺激掩蔽噪声生成方法的部分或全部步骤。例如，所述存储介质可以包括硬盘、软盘、光盘、磁带、磁盘、优盘、闪存等。Therefore, the embodiments of the present application also provide a computer-readable storage medium, the computer-readable storage medium stores a computer program, and the computer program is executed by a processor to implement any one of the cranial processes described in the above-mentioned method embodiments. Some or all of the steps of the method for generating magnetic stimulation masking noise. For example, the storage medium may include a hard disk, a floppy disk, an optical disk, a magnetic tape, a magnetic disk, a flash memory, and the like.

本申请实施方式还提供一种计算机程序产品，所述计算机程序产品包括存储了计算机程序的非瞬时性计算机可读存储介质，所述计算机程序可操作来使计算机执行如上述方法实施方式中记载的任何一种颅磁刺激掩蔽噪声生成方法的部分或全部步骤。The embodiments of the present application also provide a computer program product, the computer program product includes a non-transitory computer-readable storage medium storing a computer program, and the computer program is operable to cause the computer to execute the method as described in the above-mentioned method embodiment. Part or all of the steps of any method for generating masking noise for TMS.

需要说明的是，对于前述的各方法实施方式，为了简单描述，故将其都表述为一系列的动作组合，但是本领域技术人员应该知悉，本申请并不受所描述的动作顺序的限制，因为依据本申请，某些步骤可以采用其他顺序或者同时进行。其次，本领域技术人员也应该知悉，说明书中所描述的实施方式均属于可选的实施方式，所涉及的动作和模块并不一定是本申请所必须的。It should be noted that, for the sake of simple description, all the aforementioned method implementations are expressed as a series of action combinations, but those skilled in the art should know that the present application is not limited by the described action sequence. Depending on the application, certain steps may be performed in other orders or simultaneously. Secondly, those skilled in the art should also know that the implementations described in the specification are all optional implementations, and the actions and modules involved are not necessarily required by this application.

在上述实施方式中，对各个实施方式的描述都各有侧重，某个实施方式中没有详述的部分，可以参见其他实施方式的相关描述。In the foregoing implementation manners, the descriptions of each implementation manner have their own emphases, and for parts that are not described in detail in a certain implementation manner, refer to relevant descriptions of other implementation manners.

在本申请所提供的几个实施方式中，应该理解到，所揭露的装置，可通过其它的方式实现。例如，以上所描述的装置实施方式仅仅是示意性的，例如所述单元的划分，仅仅为一种逻辑功能划分，实际实现时可以有另外的划分方式，例如多个单元或组件可以结合或者可以集成到另一个系统，或一些特征可以忽略，或不执行。另一点，所显示或讨论的相互之间的耦合或直接耦合或通信连接可以是通过一些接口，装置或单元的间接耦合或通信连接，可以是电性或其它的形式。In the several implementation manners provided in this application, it should be understood that the disclosed device may be implemented in other ways. For example, the device implementation described above is only illustrative. For example, the division of the units is only a logical function division. In actual implementation, there may be other division methods. For example, multiple units or components can be combined or can be Integrate into another system, or some features may be ignored, or not implemented. In another point, the mutual coupling or direct coupling or communication connection shown or discussed may be through some interfaces, and the indirect coupling or communication connection of devices or units may be in electrical or other forms.

所述作为分离部件说明的单元可以是或者也可以不是物理上分开的，作为单元显示的部件可以是或者也可以不是物理单元，即可以位于一个地方，或者也可以分布到多个网络单元上。可以根据实际的需要选择其中的部分或者全部单元来实现本实施方式方案的目的。The units described as separate components may or may not be physically separated, and the components shown as units may or may not be physical units, that is, they may be located in one place, or may be distributed to multiple network units. Part or all of the units can be selected according to actual needs to achieve the purpose of the solution of this embodiment.

另外，在本申请各个实施方式中的各功能单元可以集成在一个处理单元中，也可以是各个单元单独物理存在，也可以两个或两个以上单元集成在一个单元中。上述集成的单元既可以采用硬件的形式实现，也可以采用软件程序模块的形式实现。In addition, each functional unit in each embodiment of the present application may be integrated into one processing unit, each unit may exist separately physically, or two or more units may be integrated into one unit. The above-mentioned integrated units can be implemented not only in the form of hardware, but also in the form of software program modules.

所述集成的单元如果以软件程序模块的形式实现并作为独立的产品销售或使用时，可以存储在一个计算机可读取存储器中。基于这样的理解，本申请的技术方案本质上或者说对现有技术做出贡献的部分或者该技术方案的全部或部分可以以软件产品的形式体现出来，该计算机软件产品存储在一个存储器中，包括若干指令用以使得一台计算机设备（可为个人计算机、服务器或者网络设备等）执行本申请各个实施方式所述方法的全部或部分步骤。而前述的存储器包括：U盘、只读存储器（ROM，Read-Only Memory）、随机存取存储器（RAM，Random Access Memory）、移动硬盘、磁碟或者光盘等各种可以存储程序代码的介质。The integrated units may be stored in a computer-readable memory if implemented in the form of a software program module and sold or used as an independent product. Based on this understanding, the technical solution of the present application is essentially or part of the contribution to the prior art, or all or part of the technical solution can be embodied in the form of a software product, and the computer software product is stored in a memory. Several instructions are included to make a computer device (which may be a personal computer, a server, or a network device, etc.) execute all or part of the steps of the methods described in various embodiments of the present application. The aforementioned memory includes: U disk, read-only memory (ROM, Read-Only Memory), random access memory (RAM, Random Access Memory), mobile hard disk, magnetic disk or optical disk and other media that can store program codes.

本领域普通技术人员可以理解上述实施方式的各种方法中的全部或部分步骤是可以通过程序来指令相关的硬件来完成，该程序可以存储于一计算机可读存储器中，存储器可以包括：闪存盘、只读存储器（英文：Read-Only Memory ，简称：ROM）、随机存取器（英文：Random Access Memory，简称：RAM）、磁盘或光盘等。Those of ordinary skill in the art can understand that all or part of the steps in the various methods of the above-mentioned embodiments can be completed by instructing related hardware through a program, and the program can be stored in a computer-readable memory, and the memory can include: a flash disk , Read-only memory (English: Read-Only Memory, referred to as: ROM), random access device (English: Random Access Memory, referred to as: RAM), magnetic disk or optical disc, etc.

以上对本申请实施方式进行了详细介绍，本文中应用了具体个例对本申请的原理及实施方式进行了阐述，以上实施方式的说明只是用于帮助理解本申请的方法及其核心思想；同时，对于本领域的一般技术人员，依据本申请的思想，在具体实施方式及应用范围上均会有改变之处，综上所述，本说明书内容不应理解为对本申请的限制。The implementation of the present application has been introduced in detail above, and the principle and implementation of the application have been explained by using specific examples in this paper. The description of the above implementation is only used to help understand the method and core idea of the application; at the same time, for Those skilled in the art will have changes in specific implementation methods and application scopes based on the ideas of the present application. In summary, the contents of this specification should not be construed as limiting the present application.