CN116421285A - Embryo transfer device and system - Google Patents
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Abstract
Description
Translated fromChinese技术领域technical field
本发明涉及胚胎移植技术领域，具体涉及一种胚胎移植装置和系统。The invention relates to the technical field of embryo transfer, in particular to an embryo transfer device and system.
背景技术Background technique
体外受精-胚胎移植技术(即俗称的试管婴儿)是治疗难治性不孕症的有效手段。总体而言，分为如下几个步骤：促排卵、取卵、体外受精、胚胎移植和黄体支持。其中，体外受精-胚胎移植是配子在体外形成胚胎，再将胚胎移植回女性体内的过程。In vitro fertilization-embryo transfer technology (commonly known as test-tube baby) is an effective means to treat refractory infertility. In general, it is divided into the following steps: ovulation induction, egg retrieval, in vitro fertilization, embryo transfer and luteal support. Among them, in vitro fertilization-embryo transfer is a process in which gametes form embryos outside the body and then transfer the embryos back into the female body.
胚胎移植作为试管婴儿中一个关键的环节，起着承上启下的作用。在进行胚胎移植过程中，一般包括将胚胎通过注射器将胚胎抽吸至移植内导管前端，通过胚胎移植导管内管将胚胎输送至宫颈内，然后经由移植外导管移植进入子宫腔内着床。As a key link in IVF, embryo transfer plays a connecting role. During the embryo transfer process, it generally includes sucking the embryos to the front end of the implantation catheter through a syringe, transporting the embryos to the cervix through the inner tube of the embryo transfer catheter, and then implanting them into the uterine cavity through the implantation outer catheter.
因此，能否抽吸胚胎、能否顺利着床，是影响胚胎移植结果、临床妊娠率高低的重要因素。目前现有的胚胎移植导管在吸取胚胎时易出现胚胎移位以及易引起宫缩或出血导致胚胎着床失败等问题，降低了胚胎移植的成功率。Therefore, whether the embryo can be suctioned and whether it can be implanted smoothly are important factors that affect the outcome of embryo transfer and the clinical pregnancy rate. At present, the existing embryo transfer catheter is prone to problems such as embryo displacement when sucking embryos, uterine contraction or hemorrhage, resulting in failure of embryo implantation, etc., which reduces the success rate of embryo transfer.
发明内容Contents of the invention
基于此，有必要提供一种胚胎移植装置，在胚胎移植过程中，至少解决前述提及的一个技术问题，进而提高胚胎移植的成功率。Based on this, it is necessary to provide an embryo transfer device, which can at least solve one of the above-mentioned technical problems during the embryo transfer process, thereby improving the success rate of embryo transfer.
本发明的第一目的在于提供一种胚胎移植装置，The first object of the present invention is to provide an embryo transfer device,
包括内导管组件和外导管组件；including an inner catheter assembly and an outer catheter assembly;
所述内导管组件包括内导管以及连接在所述内导管近端的内导管接头，所述内导管远端具有用于吸附胚胎的取样部，所述取样部的端面呈斜面或弧形面，所述内导管组件具有贯通所述内导管和所述内导管接头的第二容纳通道，所述第二容纳通道用于提供对胚胎的吸附力或者提供对胚胎的输送通道；The inner catheter assembly includes an inner catheter and an inner catheter connector connected to the proximal end of the inner catheter, the distal end of the inner catheter has a sampling part for absorbing embryos, and the end surface of the sampling part is a slope or an arc surface, The inner catheter assembly has a second accommodating channel passing through the inner catheter and the inner catheter connector, and the second accommodating channel is used to provide an adsorption force for embryos or provide a delivery channel for embryos;
所述外导管组件包括第一容纳通道，所述第一容纳通道的远端用于布置在植入对象的目标位置，所述取样部与所述第一容纳通道可分离连接，以使所述取样部由所述第一容纳通道到达目标位置。The outer catheter assembly includes a first receiving channel, the distal end of the first receiving channel is used to be arranged at the target position of the implanted object, and the sampling part is detachably connected with the first receiving channel, so that the The sampling part reaches the target position through the first containing channel.
本发明的一种实现方式中，取样部的径向尺寸沿朝向内导管的近端的方向逐渐增大。In an implementation manner of the present invention, the radial dimension of the sampling portion gradually increases toward the proximal end of the inner catheter.
本发明的一种实现方式中，取样部的端面与内导管的轴线的夹角为20°～70°。In an implementation manner of the present invention, the angle between the end surface of the sampling part and the axis of the inner conduit is 20°-70°.
本发明的一种实现方式中，取样部设置有物理标记，物理标记用于指示取样部的端面的朝向。In an implementation manner of the present invention, the sampling part is provided with a physical mark, and the physical mark is used to indicate the orientation of the end surface of the sampling part.
本发明的一种实现方式中，外导管组件由远端至近端依次包括软头管、外导管和外导管接头，软头管与外导管整体呈弯折结构，第一容纳通道贯通软头管、外导管和外导管接头。In one implementation of the present invention, the outer catheter assembly includes a flexible head tube, an outer catheter, and an outer catheter joint from the distal end to the proximal end. Tubes, outer conduits, and outer conduit connectors.
本发明的一种实现方式中，外导管包括弯折连接的主体部和连接部，外导管组件由远端至近端依次包括软头管、连接部、主体部和外导管接头。In one implementation of the present invention, the outer catheter includes a bent and connected main body portion and a connecting portion, and the outer catheter assembly includes a soft head tube, a connecting portion, a main body, and an outer catheter joint from the distal end to the proximal end.
本发明的一种实现方式中，弯折结构的折角为10°～50°。In an implementation manner of the present invention, the bending angle of the bending structure is 10°-50°.
本发明的一种实现方式中，外导管组件还包括用于与植入对象宫颈近端抵接的定位块，定位块套设于外导管上并可相对外导管滑动。In an implementation manner of the present invention, the outer catheter assembly further includes a positioning block for abutting against the proximal end of the cervix of the implanted object, and the positioning block is sleeved on the outer catheter and can slide relative to the outer catheter.
本发明的一种实现方式中，外导管上设有第二定位刻度，定位块与第二定位刻度配合以指示外导管进入植入对象子宫的长度；或者，In one implementation of the present invention, the outer catheter is provided with a second positioning scale, and the positioning block cooperates with the second positioning scale to indicate the length of the outer catheter entering the uterus of the implanted object; or,
定位块上设置有第二指示标记，第二指示标记与第二定位刻度配合以指示外导管进入植入对象子宫的长度。A second indicator mark is arranged on the positioning block, and the second indicator mark cooperates with the second positioning scale to indicate the length of the outer catheter entering the uterus of the implanted object.
本发明的一种实现方式中，定位块的径向尺寸沿朝向定位块的近端的方向逐渐增大，且定位块由弹性体制成。In an implementation manner of the present invention, the radial dimension of the positioning block increases gradually toward the proximal end of the positioning block, and the positioning block is made of elastic body.
本发明的一种实现方式中，胚胎移植装置包括衬芯组件，衬芯组件的硬度大于外导管，衬芯的远端呈半球形，且衬芯组件能够与第一容纳通道可分离连接。In one implementation of the present invention, the embryo transfer device includes a liner assembly, the hardness of which is greater than that of the outer catheter, the distal end of the liner is hemispherical, and the liner assembly can be detachably connected to the first containing channel.
本发明的一种实现方式中，内导管组件还包括支撑管，支撑管套设于内导管外，或，支撑管连接于内导管与内导管接头之间，支撑管的硬度大于内导管的硬度。In an implementation manner of the present invention, the inner catheter assembly further includes a support tube, the support tube is sheathed outside the inner catheter, or the support tube is connected between the inner catheter and the inner catheter connector, and the hardness of the support tube is greater than that of the inner catheter .
本发明的一种实现方式中，支撑管上设置有第一定位刻度，第一定位刻度用以指示内导管组件进入植入对象子宫的长度。In an implementation manner of the present invention, the support tube is provided with a first positioning scale, and the first positioning scale is used to indicate the length of the inner catheter assembly entering the uterus of the implanted object.
本发明的第二目的在于提供一种胚胎移植系统，包括注射器和上述胚胎移植装置。The second object of the present invention is to provide an embryo transfer system, comprising a syringe and the above-mentioned embryo transfer device.
本发明的一种实现方式中，注射器和内导管接头相适配，用于为吸取胚胎提供吸力或者为输送胚胎提供推力。In one implementation of the present invention, the syringe is adapted to the connector of the inner catheter to provide suction for aspirating embryos or provide thrust for conveying embryos.
本发明通过对胚胎移植装置中的内导管组件进行改进，增加内导管组件中内导管的取样部和胚胎的接触面积，减少吸取胚胎时胚胎移位的产生，提高吸取胚胎的速度，从而提高胚胎移植的成功率。The invention improves the inner catheter assembly in the embryo transfer device, increases the contact area between the sampling part of the inner catheter in the inner catheter assembly and the embryo, reduces the occurrence of embryo displacement when sucking the embryo, and improves the speed of sucking the embryo, thereby improving the embryo quality. Transplant success rate.
附图说明Description of drawings
图1为本实施例提供的外导管组件的结构示意图；FIG. 1 is a schematic structural view of an outer catheter assembly provided in this embodiment;
图2为本实施例提供的内导管组件的结构示意图；Figure 2 is a schematic structural view of the inner catheter assembly provided in this embodiment;
图3为本实施例提供的衬芯组件的结构示意图；Fig. 3 is a schematic structural view of the liner assembly provided in this embodiment;
图4为本实施例提供的内导管的取样部一个角度的结构示意图；Fig. 4 is a structural schematic diagram of an angle of the sampling part of the inner catheter provided by this embodiment;
图5为本实施例提供的内导管的取样部另一个角度的结构示意图。Fig. 5 is a structural schematic diagram of another angle of the sampling part of the inner catheter provided by this embodiment.
具体实施方式Detailed ways
为使本发明的上述目的、特征和优点能够更加明显易懂，下面结合附图对本发明的具体实施方式做详细的说明。在下面的描述中阐述了很多具体细节以便于充分理解本发明。但是本发明能够以很多不同于在此描述的其它方式来实施，本领域技术人员可以在不违背本发明内涵的情况下做类似改进，因此本发明不受下面公开的具体实施例的限制。In order to make the above objects, features and advantages of the present invention more comprehensible, specific implementations of the present invention will be described in detail below in conjunction with the accompanying drawings. In the following description, numerous specific details are set forth in order to provide a thorough understanding of the present invention. However, the present invention can be implemented in many other ways different from those described here, and those skilled in the art can make similar improvements without departing from the connotation of the present invention, so the present invention is not limited by the specific embodiments disclosed below.
此外，术语“第一”、“第二”仅用于描述目的，而不能理解为指示或暗示相对重要性或者隐含指明所指示的技术特征的数量。由此，限定有“第一”、“第二”的特征可以明示或者隐含地包括至少一个该特征。在本发明的描述中，“多个”的含义是至少两个，例如两个，三个等，除非另有明确具体的限定。In addition, the terms "first" and "second" are used for descriptive purposes only, and cannot be interpreted as indicating or implying relative importance or implicitly specifying the quantity of indicated technical features. Thus, the features defined as "first" and "second" may explicitly or implicitly include at least one of these features. In the description of the present invention, "plurality" means at least two, such as two, three, etc., unless otherwise specifically defined.
如本文所用，术语“近端”是指近端是指最为靠近操作者的一端，远端是指最为远离操作者的一端，对本发明的任一构件个体而言，其近端和远端也分别指该构件最为靠近操作者和最为远离操作者的一端。As used herein, the term "proximal end" means that the proximal end refers to the end closest to the operator, and the distal end refers to the end farthest from the operator. For any individual member of the present invention, its proximal end and distal end are also Respectively refer to the end of the member closest to the operator and the end farthest away from the operator.
在本发明中，除非另有明确的规定和限定，术语“安装”、“相连”、“连接”、“固定”等术语应做广义理解，例如，可以是固定连接，也可以是可拆卸连接，或成一体；可以是机械连接，也可以是电连接；可以是直接相连，也可以通过中间媒介间接相连，可以是两个元件内部的连通或两个元件的相互作用关系，除非另有明确的限定。对于本领域的普通技术人员而言，可以根据具体情况理解上述术语在本发明中的具体含义。In the present invention, unless otherwise clearly specified and limited, terms such as "installation", "connection", "connection" and "fixation" should be understood in a broad sense, for example, it can be a fixed connection or a detachable connection , or integrated; it may be mechanically connected or electrically connected; it may be directly connected or indirectly connected through an intermediary, and it may be the internal communication of two components or the interaction relationship between two components, unless otherwise specified limit. Those of ordinary skill in the art can understand the specific meanings of the above terms in the present invention according to specific situations.
除非另有定义，本文所使用的所有的技术和科学术语与属于本发明的技术领域的技术人员通常理解的含义相同。本文中在本发明的说明书中所使用的术语只是为了描述具体的实施例的目的，不是旨在于限制本发明。本文所使用的术语“和/或”包括一个或多个相关的所列项目的任意的和所有的组合。Unless otherwise defined, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the technical field of the invention. The terms used herein in the description of the present invention are for the purpose of describing specific embodiments only, and are not intended to limit the present invention. As used herein, the term "and/or" includes any and all combinations of one or more of the associated listed items.
在进行胚胎移植手术时，将胚胎移植导管通过宫颈通道的过程中，任何阻碍、延迟、损伤或微出血都可能对胚胎的植入过程造成灾难性的影响。此外，由于每个人的体质不同，胚胎移植的合适位置也不同，因此需要对胚胎移植导管进行缓慢精准的移动操作，才能够将胚胎移植到合适的位置，从而提高临床妊娠率。而现有胚胎移植导管存在吸取胚胎易发生移位，将外导管或内导管插入宫腔时，易出现宫缩或出血等导致着床失败的问题，并且现有移植导管也无法准确控制胚胎移植的位置。During the embryo transfer procedure, any obstruction, delay, injury or microbleeding during the passage of the embryo transfer catheter through the cervical passage could be disastrous for the implantation process. In addition, due to the different physiques of each person, the appropriate position for embryo transfer is also different. Therefore, the embryo transfer catheter needs to be moved slowly and accurately to transfer the embryo to the appropriate position, thereby improving the clinical pregnancy rate. However, the existing embryo transfer catheters are prone to displacement when sucking embryos. When the outer catheter or inner catheter is inserted into the uterine cavity, problems such as uterine contractions or bleeding are prone to occur, resulting in failure of implantation, and the existing transfer catheters cannot accurately control embryo transfer. s position.
为了解决以上至少一个技术问题，本发明的第一方面提供了一种胚胎移植装置，包括内导管组件和外导管组件，其中，外导管组件如图1所示，内导管组件如图2所示，外导管组件用于插入胚胎植入对象的子宫并且固定和子宫的相对位置，具有用于容纳内导管组件的作用，内导管组件用于吸取胚胎，并将胚胎通过外导管组件输送至胚胎植入对象宫腔内的目标位置。In order to solve at least one of the above technical problems, the first aspect of the present invention provides an embryo transfer device, including an inner catheter assembly and an outer catheter assembly, wherein the outer catheter assembly is shown in Figure 1, and the inner catheter assembly is shown in Figure 2 , the outer catheter assembly is used to insert the embryo into the uterus of the subject and fix the relative position of the uterus, and has the function of accommodating the inner catheter assembly, which is used to suck the embryo and transport the embryo to the embryo implantation through the outer catheter assembly into the target location within the subject's uterine cavity.
具体地，如图1所示，外导管组件由远端至近端依次包括软头管101、外导管102、定位块103和外导管接头104。外导管接头104连接于外导管102的近端，软头管101连接于外导管102的远端，且软头管101与外导管102二者整体呈折弯的结构，软头管101用于放置在植入对象的宫颈内。Specifically, as shown in FIG. 1 , the outer catheter assembly includes a
进一步的，外导管102与软导管101的连接处避开弯折位置，以便于软头管101和外导管102的连接，使得软头管101和外导管102的连接强度更高。Further, the connection between the
进一步，定位块103套设于外导管102上，并和外导管102滑动连接，并用于在将到导管组件1插入植入对象的体内时，与植入对象宫颈近端抵接，通过外力推送外导管101时，可以调整外导管102和定位块的相对位置。Further, the
一些具体实施方案中，外导管102包括主体部和连接部，外导管接头104与主体部的一端连接，连接部的一端与主体部的另一端连接，软头管与连接部在静置状态下呈整体呈直线布置，连接部与主体部呈折弯的结构。In some specific embodiments, the
一些具体实施方案中，弯折结构的折角为10°～50°，该角度范围能够适配弯折的宫颈形态，既增加外导管102的强度，同时也能提高外导管102与宫颈的匹配度。In some specific embodiments, the bending angle of the bending structure is 10°-50°, and this angle range can adapt to the shape of the bending cervix, which not only increases the strength of the
外导管组件还包括贯穿软头管101、外导管102和外导管接头104的第一容纳通道，第一容纳通道的远端用于布置在植入对象的目标位置，子宫由近端至远端包括宫颈和宫腔，该目标位置至少靠近宫颈远端，根据操作者的使用习惯也可以在宫腔内。The outer catheter assembly also includes a first accommodating passage running through the
一些实施方案中，为了在外导管102插入宫腔中时，固定外导管102与宫腔中的相对位置，定位块103和外导管102滑动连接。当外导管插入宫腔时，定位块103用于和宫颈抵接，通过外力调整外导管102和定位块103的相对位置，并通过定位块和宫颈的贴合作用固定外导管的插入位置。In some embodiments, in order to fix the relative position of the
一些实施方案中，定位块103具有定位孔，定位块103具有弹性，通过定位块103的弹性和定位孔的尺寸的设置，即可以实现在外力的作用下外导管和定位块的滑动连接，保证外导管102在外力推送下能相对定位块103发生滑动，又能通过定位块103的弹性作用，固定外导管102和定位块103的相对位置，从而利用定位块103和宫颈的敌将作用固定外导管102插入宫腔的位置。In some embodiments, the
具体地，定位孔贯穿定位块103，用以容纳外导管102，定位孔为直径均一的孔道，定位孔的直径不大于外导管的直径，且定位块为弹性材质，以使得外导管102可以插入定位孔，既能保证外导管102在外力的推送下能相对定位块103发生滑动，又能利用定位块103和外导管102的弹性固定作用，固定外导管102插入宫腔的位置，从而能够更准确地控制胚胎移植的位置，提高胚胎移植的成功率。Specifically, the positioning hole runs through the
一些实施方案中，定位块103的径向尺寸沿朝向定位块103的近端的方向逐渐增大，且定位块由弹性材料制成。In some embodiments, the radial dimension of the
一些具体实施方案中，定位块103为圆台结构，且圆台结构外径较小的一端靠近外导管的远端(即远离操作者的一端)，定位孔贯穿圆台结构的两个圆面，以减小定位块推进宫颈和与宫颈结合的难度。In some specific embodiments, the
一些具体实施方案中，定位块103采用橡胶制备而成，以使得定位块103具有弹性。In some specific embodiments, the
一些实施方案中，为了精准控制外导管的插入位置，外导管102上设有第二定位刻度105，定位块与第二定位刻度105配合以指示外导管102进入植入对象子宫的长度；或者，定位块103上设置有第二指示标记，第二指示标记与第二定位刻度105配合以指示外导管102进入植入对象子宫的长度。In some embodiments, in order to accurately control the insertion position of the outer catheter, the
具体地，外导管102上设置有第二定位刻度105，第二定位刻度105位于外导管102的远端，随着外导管102插入子宫时，定位块103能够覆盖第二定位刻度105，进而根据定位块103覆盖在定位刻度上的位置判断外导管102的插入长度。Specifically, the
一些实施方案中，为了减少对宫腔的刺激和摩擦，软头管101的硬度小于95A，为了实现这一效果，软头管101采用聚氨酯弹性体和聚醚嵌段聚酰胺中的至少一种制成。In some embodiments, in order to reduce the stimulation and friction of the uterine cavity, the hardness of the
一些实施方案中，为了保证外导管的推送力，尽可能快的将外导管插入宫颈中，外导管的硬度要求为大于50D，为了达到这一要求，外导管采用聚四氟乙烯、氟化乙丙烯、尼龙、聚乙烯和聚丙烯中的至少一种制成，以保证外导管快速、顺利的插入宫颈中，提高胚胎移植的成功率。In some embodiments, in order to ensure the pushing force of the outer catheter, insert the outer catheter into the cervix as quickly as possible, the hardness of the outer catheter is required to be greater than 50D, in order to meet this requirement, the outer catheter is made of polytetrafluoroethylene, ethyl fluoride It is made of at least one of propylene, nylon, polyethylene and polypropylene, so as to ensure the rapid and smooth insertion of the outer catheter into the cervix and improve the success rate of embryo transfer.
一些具体实施方案中，软头管101和外导管102采用热焊接的方式相连接。In some specific embodiments, the
如图2所示，内导管组件包括内导管201、支撑管202以及连接在内导管接头近端的内导管接头203。其中，支撑管202套设于内导管201外，或，支撑管202连接于内导管201与内导管接头203之间，支撑管202的硬度大于内导管201的硬度，支撑管202用于为内导管提供支撑力和推送力，以防止内导管201发生弯折，对胚胎造成挤压，影响胚胎着床的成功率。As shown in FIG. 2 , the inner catheter assembly includes an
如图3和图4所示，内导管201远端具有用于吸附胚胎的取样部204，取样部204从支撑管202伸出，取样部204的端面呈斜面或弧形面，弧形面具有与胚胎表面匹配的曲率，用于增大与胚胎的接触面积，降低胚胎移位的情况发生，提高胚胎吸取的成功率，进而提高胚胎移植的成功率。As shown in Figures 3 and 4, the distal end of the
进一步，内导管组件具有贯通内导管201第二容纳通道，第二容纳通道用于提供对胚胎的吸附力或者用于提供对胚胎的输送通道。内导管接头201具有容纳腔，该容纳腔为第二容纳通道的一部分，且用于连接注射器，以便注射器通过内导管201吸取胚胎或者在第二容纳通道内对胚胎进行推送。Further, the inner catheter assembly has a second accommodating channel passing through the
一些实施方案中，为了减小取样时内导管201对胚胎的损伤，取样部204的硬度小于95A，为了实现这一效果，取样部204采用聚氨酯弹性体和聚醚嵌段聚酰胺中的至少一种制成，以在吸取胚胎时减少对胚胎的损伤，同时较少胚胎转移过程中内导管对胚胎的摩擦，从而提高胚胎着床的成功率。In some embodiments, in order to reduce the damage of the
一些实施方案中，为了进一步避免取样部对胚胎造成损伤，斜面边缘采用圆弧钝角设计，以减少对胚胎的摩擦和损伤。In some embodiments, in order to further avoid damage to the embryo by the sampling part, the edge of the bevel is designed with an obtuse arc to reduce friction and damage to the embryo.
一些实施方案中，取样部204的端面设置有物理标记，该物理标记和端面的斜面或者圆弧面相配合，用以指示取样部吸取胚胎的方向，从而增加胚胎吸取的成功率。可以理解的是，吸取胚胎到取样部时，需要在显微镜下进行，且内导管一般是透明材质，因此是否吸取到胚胎以及如何高效吸取胚胎，可以通过该物理标记，例如，当取样部的端面布置在胚胎上方时，物理标记朝上，从而操作人员能够观察到该物理标记时，也就能够确定该取样部的端面已朝下，确保取样部与胚胎有更大的接触面积，更易吸附胚胎，同时也更加有助于取样部在进行吸附前已处于端面朝下的状态，然后再进行吸附也更加能够避免取样部戳刺胚胎，减少因胚胎损坏导致胚胎移植失败的机率。具体地，物理标记为油墨标记，或者物理标记为一凸起，也可以为其他可视化标记，标记方式不作进一步限制，只要能在吸取胚胎时正确指示取样部的吸取方向即可。In some embodiments, the end surface of the
一些实施方案中，斜面结构的斜面所在平面和内导管204轴线的夹角为20°～70°，从而增大取样部和胚胎的接触面积，提高胚胎吸取的成功率。In some embodiments, the angle between the plane of the inclined surface of the inclined surface and the axis of the
一些实施方案中，取样部的径向尺寸沿靠近内导管接头203的方向逐渐增大，以便于取样部更易进入宫腔。In some embodiments, the radial dimension of the sampling part increases gradually along the direction close to the inner catheter joint 203, so that the sampling part can enter the uterine cavity more easily.
一些实施方案中，支撑管202上设置有第一定位刻度205，第一定位刻度205位于支撑管202的近端，用以在将内导管201经外导管102插入宫腔时，用以指示内导管组件进入植入对象子宫的长度，能够更准确地控制胚胎进入宫腔后着床的位置，增加了胚胎着床的准确率，提高了胚胎移植的成功率。In some embodiments, the
一些具体实施方案中，为了保证支撑管202的支撑力，支撑管202采用不锈钢管制备而成，不锈钢管具有用于放置内导管201的第三容纳通道，以使得支撑管202对内导管201起到保护作用，防止内导管202弯折，从而避免对第一容纳通道内的胚胎造成损伤。In some specific embodiments, in order to ensure the supporting force of the
一些实施方案中，胚胎移植装置还包括衬芯组件3，外导管102的第一容纳通道还能用于容纳衬芯组件3，衬芯组件3能够为外导管组件提供支撑力和推送力，使得对于宫颈形态畸形的患者，也能将外导管组件插入宫颈内。In some embodiments, the embryo transfer device also includes a liner assembly 3, and the first accommodating channel of the
如图5所示，衬芯组件3包括衬芯301和衬芯接头302，衬芯的一端呈圆滑半球形，圆滑半球形的结构有助于衬芯301插入外导管中，帮助外导管102更顺利地进入宫颈中，衬芯301远离圆滑半球形的一端和衬芯接头302相连接。对于宫颈通道比较复杂甚至宫颈通道畸形的患者，可以根据不同患者的具体情况，选配不同的衬芯301，将衬芯301置于第一容纳通道中，提高外导管201的强度和支撑力，从而在推送外导管201时更易插入宫颈中。As shown in Figure 5, the liner assembly 3 includes a
一些实施方案中，为了保证衬芯301的推送力，衬芯301采用实心结构，衬芯组件3的硬度大于所述外导管102，具体地，衬芯301的硬度大于50D，为了达到这一要求，衬芯301采用聚四氟乙烯、氟化乙丙烯、尼龙、聚乙烯和聚丙烯中的至少一种制成，以保证外导管201顺利、快速插入宫颈内，提高胚胎移植的准确率。In some embodiments, in order to ensure the pushing force of the
本发明的第二方面提供了一种胚胎移植系统，包括注射器和上述胚胎移植装置，注射器和内导管接头203的容纳腔相适配，用于为吸取胚胎提供吸力或者为输送胚胎提供推力。The second aspect of the present invention provides an embryo transfer system, including a syringe and the above-mentioned embryo transfer device, the syringe is adapted to the cavity of the
需要说明的是，更快、更顺利以及尽可能无创伤地将胚胎尽可能接近的移植至预先设计好的胚胎着床的位置，是实现胚胎植入和妊娠的决定性因素。本发明通过对内导管组件、外导管组件进行改进，外导管组件采用柔软的软头管能够在将外导管由宫颈插入宫腔时减少对宫颈和/或宫腔的刺激和损伤，在将胚胎吸取至内导管时，内导管组件采用柔软的取样部能够快速将胚胎吸取至内导管中并减小吸取胚胎时对胚胎造成的损伤，然后将携带有胚胎的内导管由外导管进入宫腔，并将胚胎推送至胚胎着床位置，也就是说，本发明通过对内导管组件和外导管组件的组合改进，实现了更快、更顺利以及尽可能无创伤地将胚胎尽可能接近的移植至胚胎着床的位置，从而提高了胚胎移植的成功率。It should be noted that the faster, smoother and as non-invasive as possible to transfer the embryo as close as possible to the pre-designed embryo implantation position is the decisive factor to achieve embryo implantation and pregnancy. The present invention improves the inner catheter assembly and the outer catheter assembly, and the outer catheter assembly adopts a soft soft head tube, which can reduce the stimulation and damage to the cervix and/or uterine cavity when the outer catheter is inserted into the uterine cavity from the cervix. When sucking into the inner catheter, the inner catheter assembly adopts a soft sampling part to quickly suck the embryos into the inner catheter and reduce the damage to the embryos when sucking the embryos, and then the inner catheter carrying the embryos enters the uterine cavity from the outer catheter, And push the embryo to the embryo implantation position, that is to say, the present invention achieves faster, smoother and non-invasive implantation of the embryo as close as possible to the Embryo implantation position, thereby improving the success rate of embryo transfer.
以上实施例的各技术特征可以进行任意的组合，为使描述简洁，未对上述实施例中的各个技术特征所有可能的组合都进行描述，然而，只要这些技术特征的组合不存在矛盾，都应当认为是本说明书记载的范围。The technical features of the above embodiments can be combined arbitrarily. To make the description concise, all possible combinations of the technical features in the above embodiments are not described. However, as long as there is no contradiction in the combination of these technical features, they should be It is considered to be within the range described in this specification.
以上实施例仅表达了本发明的几种实施方式，其描述较为具体和详细，但并不能因此而理解为对发明专利范围的限制。应当指出的是，对于本领域的普通技术人员来说，在不脱离本发明构思的前提下，还可以做出若干变形和改进，这些都属于本发明的保护范围。因此，本发明专利的保护范围应以所附权利要求为准。The above examples only express several implementation modes of the present invention, and the description thereof is relatively specific and detailed, but it should not be construed as limiting the scope of the patent for the invention. It should be noted that, for those skilled in the art, several modifications and improvements can be made without departing from the concept of the present invention, and these all belong to the protection scope of the present invention. Therefore, the protection scope of the patent for the present invention should be based on the appended claims.
Claims (15)
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| Application Number | Priority Date | Filing Date | Title |
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| CN202210006303.9ACN116421285A (en) | 2022-01-04 | 2022-01-04 | Embryo transfer device and system |
| PCT/CN2023/070463WO2023131190A1 (en) | 2022-01-04 | 2023-01-04 | Embryo transfer device and system |
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| JPH1119094A (en)* | 1997-07-08 | 1999-01-26 | Kitazato Supply:Kk | Catheter for transplantation of egg or embryo |
| CN201227315Y (en)* | 2008-07-30 | 2009-04-29 | 毕宜法 | Embryo transplantation hose |
| CN113749746A (en)* | 2021-10-21 | 2021-12-07 | 上海上医康鸽医用器材有限责任公司 | Embryo transfer catheter device |
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