Disclosure of Invention
In order to improve the treatment efficiency of the photodynamic therapeutic apparatus, the present application provides a photodynamic therapeutic apparatus.
The technical scheme is as follows:
the utility model provides a photodynamic therapy apparatus, includes laser light source, is used for controlling every laser light source's drive module, leaded light subassembly, first optic fibre, light filter, adjustment subassembly, absorption pond and be used for holding the complete machine shell of above-mentioned subassembly, photodynamic therapy apparatus still includes control module, leaded light subassembly and first optic fibre set gradually in laser light source's light-emitting direction, the light filter is located between leaded light subassembly and the first optic fibre, control module with drive module and adjustment subassembly electric connection, laser light source includes treatment light source and pilot light source, control module is used for controlling treatment light source and pilot light source and selectively luminous;
the adjusting component is connected with the optical filter, when the photodynamic therapeutic apparatus is in a diagnosis state, the therapeutic light source and the indicating light source emit light simultaneously, the optical filter is positioned on the light-emitting light path of the light guide component by the adjusting component, the indicating light source is transmitted by the optical filter, and the therapeutic light source is absorbed by the absorption pool; when the photodynamic therapeutic apparatus is in a therapeutic state, the optical filter leaves the light-emitting light path of the light guide assembly to enable the therapeutic light source to emit light, and the light source emitted from the light guide assembly is directly coupled into the first optical fiber.
By adopting the technical scheme, the photodynamic therapeutic apparatus can be switched between the therapeutic light source and the indication light source, when the indication light source is used, the control module controls the adjusting component to enable the filter to be positioned in the light emitting direction of the light guide component so as to reflect therapeutic light emitted by the therapeutic light source and transmit the therapeutic light into the absorption tank for absorption, and further, the loss of the therapeutic light to other components in the therapeutic apparatus is avoided; when the treatment light source is used, the control module controls the adjusting component to enable the optical filter to be far away from the light emitting direction of the light guide component, so that treatment light is directly incident into the first optical fiber to treat the lesion position of a patient, the effect of switching treatment light and indication light at any time by using the same therapeutic instrument is achieved, and the treatment efficiency of the photodynamic therapeutic instrument is improved.
Optionally, the adjustment assembly includes the shell and sets up in the inside electric telescopic handle of shell, control module control electric telescopic handle adjusts the position of light filter.
By adopting the technical scheme, the control module adjusts the position of the optical filter in the light path by controlling the electric telescopic rod to stretch, thereby controlling whether the optical filter reflects the therapeutic light or not, and further completing the switching between the indicating light and the therapeutic light.
Optionally, the device further comprises a feedback component, wherein the feedback component is used for receiving the light reflected by the light guide component and feeding back the light to the control module.
By adopting the technical scheme, the feedback component is arranged to enable the control module to monitor the output power of the therapeutic light source and the indicating light source in real time, so as to adjust the output power of the light source which does not meet the working requirements of therapeutic light or indicating light, and further improve the therapeutic effect of the photodynamic therapeutic apparatus on the lesion part.
Optionally, the feedback assembly includes speculum, a plurality of beam splitting component and a plurality of detection unit, the speculum is used for receiving the light that leads the optical subassembly reflection, beam splitting component with the detection unit one-to-one, every beam splitting component all set up in on the reflection path of speculum, the detection unit can receive the light that beam splitting component reflected, the light that the speculum reflected is after each beam splitting component transmission and reflection for the light of preset wavelength is reflected to corresponding detection unit in, a plurality of detection units all with control module electric connection, control module is according to the light intensity adjustment of detection unit received light the treatment light source with the power of instruction light source.
By adopting the technical scheme, the light received by the reflecting mirror is reflected to the light splitting element, so that the light is sequentially split by the light splitting elements, and the split light is reflected to the detection unit, so that the detection unit transmits the light intensity detected in real time to the control module, the real-time output power of each light is obtained, and the control module completes the feedback of the treatment light source and the indication light source according to the real-time output power, thereby improving the treatment effect of the photodynamic therapeutic apparatus.
Optionally, the optical filter is plated with a reflective film capable of reflecting light with the wavelength of 400-580nm and a transmissive film capable of transmitting light with the wavelength of 630-840 nm.
By adopting the technical scheme, the treatment light can be effectively blocked, so that the treatment light is reflected to the absorption tank through the optical filter when in a diagnosis state, and meanwhile, the indication light can be better transmitted through the optical filter, and the focus position of a patient is searched.
Optionally, the photodynamic therapeutic apparatus includes a plurality of therapeutic light sources and a plurality of driving modules, the driving modules are in one-to-one correspondence with the therapeutic light sources, and wavelengths emitted by the therapeutic light sources are different from each other.
By adopting the technical scheme, a plurality of treatment light sources with different wavelengths are arranged, so that the photodynamic therapeutic apparatus can selectively treat different lesion tissue positions in a targeted manner, and the treatment effect of the photodynamic therapeutic apparatus on the lesion sites is improved.
Optionally, the drive module controls one or more of the plurality of therapeutic light sources to emit light independently.
Through adopting above-mentioned technical scheme, photodynamic therapy appearance both can realize single wavelength laser output, can realize a plurality of wavelength and export simultaneously again, can select the laser of different wavelength of output to different pathological change positions to treat, can further promote treatment.
Optionally, the therapeutic light source is a semiconductor laser or a self-frequency doubling laser.
By adopting the technical scheme, the semiconductor laser or the self-frequency doubling laser is selected as the treatment light source, so that the output wavelength of the treatment light source can be effectively increased, and the output efficiency and the output power stability of the light source are improved.
Optionally, the light guide assembly includes a plurality of second optical fibers and focusing lens, the treatment light source and the indication light source are all in one-to-one correspondence with the second optical fibers, a plurality of second optical fibers are bundled and fixed to form an optical fiber bundle, and the light emitting direction of the optical fiber bundle is provided with the focusing lens, so that light emitted by the optical fiber bundle is coupled into the first optical fiber.
Through adopting above-mentioned technical scheme, bind the light-emitting end of second optic fibre and fix and form the optical fiber bundle, can acquire highly uniform coincidence and large tracts of land facula output, direct simultaneously make second optic fibre need not with the optical fiber bundle coupling through binding the light-emitting end of second optic fibre, the light path is succinct more and can reduce the power loss of coupling.
Optionally, the device further comprises pedals, wherein the pedals are respectively and electrically connected with the control module and the adjusting component.
By adopting the technical scheme, the whole treatment process can realize the switching between the treatment light and the indication light only by stepping on the foot switch, so that the treatment efficiency of the photodynamic therapeutic apparatus is improved, and when a user steps on the foot switch, the photodynamic therapeutic apparatus can output laser according to a set value, thereby completing the focus indication and treatment of the user.
In summary, the present application includes at least one of the following beneficial technical effects:
1. the photodynamic therapeutic apparatus can switch between the therapeutic light source and the indication light source, when the indication light source is used, the control module controls the adjusting component to enable the filter to be located in the light emitting direction of the light guide component so as to reflect therapeutic light emitted by the therapeutic light source and transmit the therapeutic light to the absorption tank for absorption, and further loss of the therapeutic light to other components in the therapeutic apparatus is avoided; when the treatment light source is used, the control module controls the adjusting component to enable the optical filter to be far away from the light emitting direction of the light guide component, so that treatment light is directly incident into the first optical fiber to treat the lesion position of a patient, the effect of switching the treatment light and the indication light at any time by using the same therapeutic instrument is achieved, and the treatment efficiency of the photodynamic therapeutic instrument is further improved;
2. the plurality of treatment light sources with different wavelengths are arranged, so that the photodynamic therapeutic apparatus can selectively treat different lesion tissue positions in a targeted manner, and the treatment effect of the photodynamic therapeutic apparatus on the lesion sites is improved.
Detailed Description
A further detailed description of the present application is provided below in connection with figures 1-3. The following examples are illustrative of the invention and are not intended to limit the scope of the invention.
Before describing embodiments of the present invention, some terms involved in the embodiments of the present invention will be first defined and described.
Photodynamic therapy (PDT) is an emerging field of tumor treatment, and has become a novel therapy for treating malignant tumors and various skin diseases due to the advantages of small wounds, low toxic and side effects, good selectivity, good applicability, repeated treatment, palliative treatment, synergistic treatment, elimination of hidden cancer lesions, protection of important organ functions from damage and the like.
The mechanism of action of photodynamic therapy is that a photosensitizer is injected into a patient vein, the photosensitizer is specifically accumulated and stored in malignant tumor, after a period of time, the photosensitizer in the tumor is excited by using specific wavelength illumination, so that the photosensitizer generates active oxygen substances including singlet oxygen or other active oxygen, and apoptosis is induced or caused by tumor tissue necrosis and killing tumor cells through a non-apoptosis path or directly and efficiently.
Referring to fig. 1 and 2, an embodiment of the present application provides a photodynamic therapy device, which includes a laser light source 1, adriving module 2 for controlling the laser light source 1, a light guiding component 3, a first optical fiber 4, anoptical filter 5, anadjusting component 6, anabsorption tank 7, and acomplete machine housing 8 for accommodating the above components, and further includes acontrol module 9.
The laser light source 1 is used for respectively emitting laser light with different wavelengths, and the laser light source 1 comprises a treatment light source 11 and anindication light source 12.
The therapeutic light source 11 is configured to emit light having an activating effect on a photosensitizer, for example, a camptotheca of a photosensitizer commonly used in PDT, as shown in fig. 3, an absorption spectrum of the camptotheca has 5 main absorption peaks in a visible light range, and wavelengths are 405nm, 504nm, 538nm, 572nm and 624nm in sequence, and when the therapeutic light source 11 is capable of emitting light having wavelengths of 405nm, 504nm, 538nm, 572nm and 624nm, treatment can be performed on a lesion position of a patient.
The therapeutic light source 11 may be selected from 405nm semiconductor laser, 504nm self-frequency-doubling laser, 538nm self-frequency-doubling laser, 572nm self-frequency-doubling laser, and 624nm semiconductor laser. Wherein, gain mediums of the 504nm self-frequency-doubling laser, the 538nm self-frequency-doubling laser and the 572nm self-frequency-doubling laser are all doped with Yb3+ The YCOB crystal material of the ion is produced. The self-frequency doubling laser can effectively increase the output wavelength of the therapeutic light source and improve the output efficiency and the output power stability of the light source.
The photodynamic therapeutic apparatus may also include a plurality of therapeutic light sources 11 and a plurality of drivingmodules 2, where the drivingmodules 2 are in one-to-one correspondence with the therapeutic light sources 11, and wavelengths emitted by the therapeutic light sources 11 are different from each other. The photodynamic therapeutic apparatus can selectively treat different pathological tissue positions in a targeted manner, so that the therapeutic effect of the photodynamic therapeutic apparatus on the pathological change position is improved.
The light guide component 3 and the first optical fiber 4 are both arranged in the light emitting direction of the laser light source 1, theoptical filter 5 is positioned between the light guide component 3 and the first optical fiber 4, thecontrol module 9 is electrically connected with thedriving module 2 and theadjusting component 6, and thecontrol module 9 is used for controlling the therapeutic light source 11 and theindication light source 12 to selectively emit light.
A semiconductor laser with 638nm wavelength is used as anindication light source 12, after the first optical fiber 4 stretches into the patient, the indication light emitted by theindication light source 12 is input into the first optical fiber 4 through the light guide component 3 and theoptical filter 5, and the lesion target tissue is found through the indication light, so that the subsequent treatment light irradiates the lesion target tissue.
Thedriving module 2 is used for controlling the on or off of the therapeutic light source 11 and the indicatinglight source 12, and thedriving module 2 may be a driving circuit, wherein when the photodynamic therapeutic apparatus has a plurality of therapeutic light sources 11, thedriving module 2 controls one or more of the therapeutic light sources 11 to emit light independently. The photodynamic therapeutic instrument can realize single-wavelength laser output and multiple-wavelength simultaneous output, can select and output lasers with different wavelengths for treatment aiming at different lesion positions, and can further improve the treatment effect.
The first optical fiber 4 is adapted to extend into the patient and illuminate the patient's focal tissue through the fiber end face.
The light guide assembly 3 is used for coupling light emitted by the laser light source 1 into the first optical fiber 4, and the light guide assembly 3 and the first optical fiber 4 are both arranged in the light emitting direction of the laser light source 1. In one example, the light guide assembly 3 includes a plurality of secondoptical fibers 31 and a focusinglens 32, the laser light sources 1 are in one-to-one correspondence with the secondoptical fibers 31, the plurality of secondoptical fibers 31 are bundled and fixed to form anoptical fiber bundle 311, and the focusinglens 32 is disposed in the light emitting direction of theoptical fiber bundle 311, so that the light emitted by theoptical fiber bundle 311 is coupled into the first optical fiber 4. The light emitting end of the secondoptical fiber 31 is bound and fixed to form theoptical fiber bundle 311, so that the light spot output with uniform height and large area can be obtained, meanwhile, the secondoptical fiber 31 is directly bound by the light emitting end of the secondoptical fiber 31, so that the secondoptical fiber 31 does not need to be coupled with theoptical fiber bundle 311, and meanwhile, the light path is simpler and the coupled power loss can be reduced.
The first optical fiber 4 and the secondoptical fiber 31 have the same structure, so that the light emitting efficiency of the laser emitted by the laser source 1 is consistent, and a higher laser energy density can be provided, so that stable coupling of high peak power laser is ensured, and the light energy incident to focus tissues of a user is improved.
Theoptical filter 5 is used for reflecting therapeutic light and transmitting indicating light, and theoptical filter 5 is located between the light guide assembly 3 and the first optical fiber 4. Theoptical filter 5 is coated with a reflective film capable of reflecting light having a wavelength of 400-580nm and a transmissive film capable of transmitting light having a wavelength of 630-840 nm. The reflective film can effectively block therapeutic light, so that the therapeutic light is reflected to theabsorption pool 7 through theoptical filter 5 when indicating focus tissues, and meanwhile, the indicating light can be better transmitted through theoptical filter 5, and the focus position of a patient is found.
The adjustingcomponent 6 is connected with theoptical filter 5, the adjustingcomponent 6 is used for adjusting the position of theoptical filter 5 in the light path, when the photodynamic therapeutic apparatus is in a diagnosis state, the therapeutic light source 11 and theindication light source 12 emit light simultaneously, the adjustingcomponent 6 enables theoptical filter 5 to be positioned on the light-emitting light path of the light guide component 3, theoptical filter 5 transmits theindication light source 12, and theabsorption cell 7 absorbs the therapeutic light source 11; when the photodynamic therapeutic apparatus is in a therapeutic state, theoptical filter 5 leaves the light-emitting light path of the light guide assembly 3 to make the therapeutic light source 11 emit light, and the light source emitted from the light guide assembly 3 is directly coupled into the first optical fiber 4.
The adjustingassembly 6 comprises ahousing 61 and an electrictelescopic rod 62 arranged inside thehousing 61, and thecontrol module 9 controls the electrictelescopic rod 62 to adjust the position of theoptical filter 5. Thecontrol module 9 controls the electrictelescopic rod 62 to stretch and retract so as to adjust the position of theoptical filter 5 in the light path, thereby controlling whether theoptical filter 5 reflects the therapeutic light or not, and further completing the switching between the indicating light and the therapeutic light.
Thewhole machine shell 8 is used for packaging the laser light source 1, thedriving module 2, the light guide component 3, the first optical fiber 4, theoptical filter 5, the adjustingcomponent 6 and theabsorption tank 7 to avoid damage to the components in the use process, and the first optical fiber 4 stretches out of thewhole machine shell 8 as a treatment end to stretch into a patient for illumination treatment during treatment.
The photodynamic therapy apparatus further comprises acontrol module 9, wherein thecontrol module 9 is electrically connected with thedriving module 2 and theadjusting component 6, and thecontrol module 9 is used for controlling the therapy light source 11 and theindication light source 12 to selectively emit light. Thecontrol module 9 may be an upper computer, a processor disposed in thewhole machine casing 8, or a control computer connected to a system bus. If the photodynamic therapeutic apparatus is intermittently output, the user needs to give the data such as peak current, pulse width, pulse interval, pulse number and the like of the photodynamic therapeutic apparatus, and if the photodynamic therapeutic apparatus is required to continuously output, the working time and the working power of the photodynamic therapeutic apparatus need to be given.
The photodynamic therapeutic apparatus can switch between the therapeutic light source 11 and theindication light source 12, when theindication light source 12 is used, thecontrol module 9 controls theadjusting component 6 to enable the filter to be positioned in the light emitting direction of the light guide component 3 so as to reflect therapeutic light emitted by the therapeutic light source 11 and transmit the therapeutic light to theabsorption tank 7 for absorption, thereby avoiding the loss of the therapeutic light to other components in the therapeutic apparatus; when the treatment light source 11 is used, thecontrol module 9 controls theadjusting component 6 to enable theoptical filter 5 to be far away from the light emitting direction of the light guide component 3, so that treatment light is directly incident into the first optical fiber 4 to treat the lesion position of a patient, the effect of switching the treatment light and the indication light at any time is achieved, and the treatment efficiency of the photodynamic therapeutic apparatus is improved.
The photodynamic therapy device further comprises afeedback assembly 10, wherein thefeedback assembly 10 is used for receiving the light reflected by the light guide assembly 3 and feeding back the light to thecontrol module 9. Thefeedback component 10 is arranged to enable thecontrol module 9 to monitor the output power of the therapeutic light source 11 and the indicatinglight source 12 in real time, so as to adjust the output power of the light source which does not meet the working requirements of therapeutic light or indicating light, and further improve the therapeutic effect of the photodynamic therapeutic apparatus on the lesion part.
In one example, thefeedback assembly 10 includes amirror 101, a plurality oflight splitting elements 102, and a plurality ofdetection units 103.
The reflectingmirror 101 is configured to receive the light reflected by the light guiding component 3, where the reflectingmirror 101 forms 45 ° with the light emitting direction of the light guiding component 3, so that the light can be better transmitted to thelight splitting element 102.
Thelight splitting elements 102 are configured to split the light reflected by the reflectingmirror 101, and eachlight splitting element 102 is disposed on a reflection path of the reflectingmirror 101, and thelight splitting element 102 may be theoptical filter 5.
Thedetection units 103 are configured to receive the light reflected by thelight splitting elements 102, thelight splitting elements 102 are in one-to-one correspondence with thedetection units 103, after the light reflected by the reflectingmirror 101 is transmitted and reflected by eachlight splitting element 102, the light with the preset wavelength is reflected to the correspondingdetection unit 103, thedetection units 103 are electrically connected to thecontrol module 9, and thecontrol module 9 adjusts the power of the therapeutic light source 11 and the indicatinglight source 12 according to the light intensity of the light received by thedetection units 103.
The light received by the reflectingmirror 101 is reflected to thelight splitting element 102, so that the light is split by thelight splitting elements 102 in sequence, and the split light is reflected to thedetection unit 103, so that thedetection unit 103 transmits the light intensity detected in real time to thecontrol module 9, and thus the real-time output power of each light is obtained, and thecontrol module 9 completes the feedback to the therapeutic light source 11 and the indicatinglight source 12 according to the real-time output power, so that the therapeutic effect of the photodynamic therapeutic apparatus is improved.
Working principle of photodynamic therapeutic equipment: the laser light source 1 to be started is input through the control module 9, the control module 9 sends an instruction to the driving module 2 so as to enable the corresponding laser light source 1 to be started, at the moment, laser output by the treatment light source 11 and/or the indication light source 12 is output to the focusing lens 32 through the second optical fiber 31 and the optical fiber bundle 311 formed by binding and fixing the second optical fiber 31, a user controls the position of the optical filter 5 through stepping on the pedal 91, when the user steps on the pedal 91 once, the adjusting assembly 6 moves towards the light emitting direction of the focusing lens 32 along with the optical filter 5 until the optical filter 5 is positioned on the light emitting path of the focusing lens 32, and as a film layer for reflecting treatment light is plated on the optical filter 5, the optical filter 5 can only transmit the instruction so as to diagnose the focus position of a patient; when the user steps on the pedal 91 again, the adjusting component 6 will move with the optical filter 5 in the light-emitting direction away from the focusing lens 32 until the optical filter 5 leaves the light-emitting path of the focusing lens 32, and at this time, the indication light source 12 is turned off, only therapeutic light is input into the first optical fiber 4, and the treatment of the patient is completed; at the same time of starting the therapeutic light source 11 and/or the indication light source 12, the light emitted by each light source is reflected at the focusing lens 32, and the reflected light is reflected again at the reflecting mirror 101, so that the optical fiber splits at each splitting element 102, the light with preset wavelength is reflected to the corresponding detection unit 103, and finally the light with different wavelength is received by the detection unit 103, and the signal is transmitted to the control module 9, so as to monitor the change of the laser output power in real time.
The embodiments of the present invention are all preferred embodiments of the present application, and are not intended to limit the scope of the present application in this way, therefore: all equivalent changes in structure, shape and principle of this application should be covered in the protection scope of this application.