CN115997965A - A kind of nicotine sustained-release snus and its preparation method - Google Patents
A kind of nicotine sustained-release snus and its preparation methodDownload PDFInfo
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Abstract
Description
Translated fromChinese技术领域technical field
本发明涉及尼古丁制品生产技术领域，尤其是指一种尼古丁缓释型口含烟及其制备方法。The invention relates to the technical field of nicotine product production, in particular to a nicotine sustained-release snus and a preparation method thereof.
背景技术Background technique
烟碱是烟草中一种非常重要的生物碱，也是口含型无烟烟草制品的一种重要成分，是给烟草制品使用者带来满足感和愉悦感的主要成分。烟碱释放速率和释放量是口含型无烟烟草制品质量安全的重要指标。目前用于口含烟制品中的尼古丁多以烟草提取物、游离尼古丁、液体尼古丁盐等形式存在，这会使产品在消费时，烟碱释放速率过快、口含前期劲头过大后期劲头较小、整个口含过程中烟味快速变淡的不足。Nicotine is a very important alkaloid in tobacco and an important component of buccal smokeless tobacco products. It is the main component that brings satisfaction and pleasure to tobacco product users. The release rate and amount of nicotine are important indicators of the quality and safety of buccal smokeless tobacco products. The nicotine currently used in snus products mostly exists in the form of tobacco extract, free nicotine, liquid nicotine salt, etc., which will cause the product to release nicotine too quickly when the product is consumed, and the strength of the mouth is too strong in the early stage and the strength in the later stage is weaker. Small, the shortcoming that the smoke taste fades quickly during the whole mouthful process.
为了达到对口含型无烟烟草制品烟碱释放的有效控制，研究人员已开展了一些烟碱释放方面的研究工作，并取得一些成果。市面上现有的缓释口含烟制品，主要是将烟草提取物或者尼古丁做成微胶囊的形式来实现缓释，工艺较为复杂。In order to achieve effective control of nicotine release from snuff-type smokeless tobacco products, researchers have carried out some research work on nicotine release and achieved some results. The existing slow-release snus products on the market mainly use tobacco extract or nicotine in the form of microcapsules to achieve sustained release, and the process is relatively complicated.
因此，研究出一种工艺简单，且能让尼古丁在口腔中均匀、缓慢、持久释放，为消费者提供长效平和的生理满足感的缓释口含烟制品是必要的。Therefore, it is necessary to develop a slow-release snus product that has a simple process, can release nicotine uniformly, slowly and persistently in the oral cavity, and provides consumers with long-acting and peaceful physiological satisfaction.
发明内容Contents of the invention
针对现有技术的缺点，本发明提供一种尼古丁缓释型口含烟，克服了现有的不足，通过尼古丁与不同有机酸形成的尼古丁盐在口含过程中释放速率的不同，对多种固体尼古丁有机酸盐进行复配，从而保证口含过程中能在较长的时间内保持稳定的劲头，能让尼古丁在口腔中均匀、缓慢、持久释放，为消费者提供长效平和的生理满足感，同时能有效降低对消化道的刺激性。Aiming at the shortcomings of the prior art, the present invention provides a sustained-release nicotine snus, which overcomes the existing deficiencies. The release rate of nicotine salts formed by nicotine and different organic acids is different in the process of snus. Solid nicotine organic acid salts are compounded to ensure that the nicotine can be kept stable for a long period of time during the oral intake process, allowing nicotine to be released evenly, slowly and persistently in the mouth, providing consumers with long-lasting and peaceful physiological satisfaction Sensation, at the same time can effectively reduce the irritation to the digestive tract.
本发明还提供一种尼古丁缓释型口含烟的制备方法，工艺简单易操作，可采用自动化生产，便于大规模生产。The invention also provides a preparation method of the nicotine slow-release snus, the process is simple and easy to operate, automatic production can be adopted, and large-scale production is convenient.
具体的，本发明公开一种尼古丁缓释型口含烟，包含混合尼古丁盐、纤维素、矫味剂、保润剂和抗氧化剂。Specifically, the invention discloses a nicotine slow-release snus, which comprises mixed nicotine salt, cellulose, flavoring agent, humectant and antioxidant.
优选的，按质量分数计，包含：混合尼古丁盐1-20％，纤维素55-70％，矫味剂1-15％，保润剂1-5％，抗氧化剂1-5％；所述混合尼古丁盐为液体尼古丁-苯甲酸盐、固体尼古丁-酒石酸盐、固体尼古丁-海藻酸盐的混合物。Preferably, in terms of mass fraction, it comprises: 1-20% of mixed nicotine salt, 55-70% of cellulose, 1-15% of flavoring agent, 1-5% of humectant, and 1-5% of antioxidant; Mixed nicotine salt is a mixture of liquid nicotine-benzoate, solid nicotine-tartrate, and solid nicotine-alginate.
优选的，所述混合尼古丁盐中，液体尼古丁-苯甲酸盐占混合尼古丁盐质量分数的8-15％，固体尼古丁-酒石酸盐占混合尼古丁盐质量分数的30-40％，固体尼古丁-海藻酸盐占混合尼古丁盐质量分数的50-60％。Preferably, in the mixed nicotine salt, the liquid nicotine-benzoate accounts for 8-15% of the mass fraction of the mixed nicotine salt, the solid nicotine-tartrate accounts for 30-40% of the mixed nicotine salt, and the solid nicotine-seaweed Salts account for 50-60% of the mass fraction of mixed nicotine salts.
优选的，所述纤维素选自天然纤维、微晶纤维素、纤维素衍生物中的至少一种。Preferably, the cellulose is selected from at least one of natural fibers, microcrystalline cellulose, and cellulose derivatives.
优选的，所述矫味剂选自单糖、二糖、三糖、多糖、多元醇、增甜剂中的至少一种。Preferably, the flavoring agent is selected from at least one of monosaccharides, disaccharides, trisaccharides, polysaccharides, polyalcohols, and sweeteners.
优选的，所述保润剂选自丙二醇、丙三醇中的至少一种。Preferably, the humectant is selected from at least one of propylene glycol and glycerin.
优选的，所述抗氧化剂选自维生素A、维生素C、维生素E中的至少一种。Preferably, the antioxidant is selected from at least one of vitamin A, vitamin C, and vitamin E.
优选的，还包括酸碱调节剂和氯化钠，所述酸碱调节剂的质量分数为1-5％，选自碳酸氢钠、碳酸钠中的至少一种；所述氯化钠的质量分数为3-5％。Preferably, it also includes acid-base regulator and sodium chloride, the mass fraction of the acid-base regulator is 1-5%, at least one selected from sodium bicarbonate and sodium carbonate; the mass fraction of the sodium chloride The score is 3-5%.
优选的，还包括水。Preferably, water is also included.
本发明还公开上述的尼古丁缓释型口含烟的制备方法，包含以下步骤：The present invention also discloses a preparation method of the above-mentioned nicotine sustained-release snus, which comprises the following steps:
混合，将混合尼古丁盐、纤维素、保润剂混合，得到第一混合物；mixing, mixing the mixed nicotine salt, cellulose, and humectant to obtain the first mixture;
加热，对第一混合物进行烘烤和加热处理，然后加入水、氯化钠和酸碱调节剂混合后冷藏，得到第二混合物；heating, toasting and heat-treating the first mixture, then adding water, sodium chloride and an acid-base regulator, mixing and then refrigerating to obtain the second mixture;
杀菌，在第二混合物上添加矫味剂、抗氧化剂，密封冷藏后杀菌处理，得到尼古丁缓释型口含烟。Sterilization, adding flavoring agents and antioxidants to the second mixture, sealing and refrigerating, and then sterilizing to obtain nicotine sustained-release snus.
有益效果：Beneficial effect:
(1)本发明的尼古丁缓释型口含烟，通过尼古丁与不同有机酸形成的尼古丁盐在口含过程中释放速率的不同，对多种固体尼古丁有机酸盐的复配，形成复合型固体尼古丁盐，来实现缓释效果；可以满足口含烟在较长的时间内保持稳定的劲头，能让尼古丁在口腔中均匀、缓慢、持久释放，为消费者提供长效平和的生理满足感，同时能有效降低对消化道的刺激性。(1) The nicotine slow-release snus of the present invention forms a composite solid through the compounding of various solid nicotine organic acid salts through the difference in the release rate of nicotine salts formed by nicotine and different organic acids in the buccal process. Nicotine salt to achieve sustained release effect; it can satisfy snus to maintain a stable momentum for a long time, allowing nicotine to be released evenly, slowly and persistently in the mouth, providing consumers with long-lasting and peaceful physiological satisfaction. At the same time, it can effectively reduce the irritation to the digestive tract.
(2)本发明的尼古丁缓释型口含烟的制备方法，先对混合尼古丁盐、纤维素和保润剂混合，保证口含烟的口感以及缓释效果，再加入水、氯化钠、酸碱调节剂保证口含烟的酸碱度复合标准，最后加入矫味剂、抗氧化剂，调节口含烟味道并提高稳定性，最终制得尼古丁缓释型口含烟，保证了口含烟的缓蚀效果、口感、味道和稳定性，同时工艺简单易操作，可采用自动化生产，便于大规模生产。(2) The preparation method of the nicotine sustained-release snus of the present invention is first mixed with nicotine salt, cellulose and a humectant to ensure the mouthfeel and slow-release effect of the snus, and then add water, sodium chloride, The acid-base regulator ensures the pH composite standard of snus, and finally adds flavoring agents and antioxidants to adjust the taste and improve the stability of snus, and finally produce nicotine slow-release snus, which ensures the slow-release of snus. Corrosion effect, mouthfeel, taste and stability, while the process is simple and easy to operate, automatic production can be adopted, and it is convenient for large-scale production.
附图说明Description of drawings
为了更清楚地说明本发明技术方案，下面将对实施例描述中所需要使用的附图作简单地介绍，显而易见地，下面描述中的附图是本发明的一些实施例，对于本领域普通技术人员来讲，在不付出创造性劳动的前提下，还可以根据这些附图获得其他的附图。In order to illustrate the technical solution of the present invention more clearly, the following will briefly introduce the accompanying drawings that are required in the description of the embodiments. Obviously, the accompanying drawings in the following description are some embodiments of the present invention. As far as people are concerned, other drawings can also be obtained based on these drawings on the premise of not paying creative work.
图1为本发明实施例1-5制备的尼古丁缓释型口含烟的释放曲线；Fig. 1 is the release curve of the nicotine sustained-release snus prepared by Examples 1-5 of the present invention;
图2为对比例1-7制备的口含烟的释放曲线。Fig. 2 is the release curve of the snus prepared in Comparative Examples 1-7.
具体实施方式Detailed ways
下面将结合本发明实施例中的附图，对本发明实施例中的技术方案进行清楚、完整地描述。显然，所描述的实施例是本发明一部分实施例，而不是全部的实施例。基于本发明中的实施例，本领域普通技术人员在没有做出创造性劳动前提下所获得的所有其他实施例，都属于本发明保护的范围。The following will clearly and completely describe the technical solutions in the embodiments of the present invention with reference to the drawings in the embodiments of the present invention. Apparently, the described embodiments are some, but not all, embodiments of the present invention. Based on the embodiments of the present invention, all other embodiments obtained by persons of ordinary skill in the art without making creative efforts belong to the protection scope of the present invention.
应当理解，当在本说明书和所附权利要求书中使用时，术语“包括”和“包含”指示所描述特征、整体、步骤、操作、元素和/或组件的存在，但并不排除一个或多个其它特征、整体、步骤、操作、元素、组件和/或其集合的存在或添加。It should be understood that when used in this specification and the appended claims, the terms "comprising" and "comprises" indicate the presence of described features, integers, steps, operations, elements and/or components, but do not exclude one or Presence or addition of multiple other features, integers, steps, operations, elements, components and/or collections thereof.
还应当理解，在此本发明说明书中所使用的术语仅仅是出于描述特定实施例的目的而并不意在限制本发明。如在本发明说明书和所附权利要求书中所使用的那样，除非上下文清楚地指明其它情况，否则单数形式的“一”、“一个”及“该”意在包括复数形式。It should also be understood that the terminology used in the description of the present invention is for the purpose of describing particular embodiments only and is not intended to be limiting of the present invention. As used in this specification and the appended claims, the singular forms "a", "an" and "the" are intended to include plural referents unless the context clearly dictates otherwise.
还应当进一步理解，在本发明说明书和所附权利要求书中使用的术语“和/或”是指相关联列出的项中的一个或多个的任何组合以及所有可能组合，并且包括这些组合。It should also be further understood that the term "and/or" used in the description of the present invention and the appended claims refers to any combination and all possible combinations of one or more of the associated listed items, and includes these combinations .
还应当进一步理解，在本发明说明书和所附权利要求书中使用的术语“浓度”是指质量浓度，而“％”是指质量百分含量；另有解释说明的除外。It should be further understood that the term "concentration" used in the description of the present invention and the appended claims refers to mass concentration, while "%" refers to mass percentage; unless otherwise explained.
一种尼古丁缓释型口含烟，包含混合尼古丁盐、纤维素、矫味剂、保润剂和抗氧化剂。A nicotine sustained-release snus, which contains mixed nicotine salt, cellulose, flavoring agent, humectant and antioxidant.
按质量分数计，包含：混合尼古丁盐1-20％，纤维素55-70％，矫味剂1-15％，保润剂1-5％，抗氧化剂1-5％；混合尼古丁盐为液体尼古丁-苯甲酸盐、固体尼古丁-酒石酸盐、固体尼古丁-海藻酸盐的混合物。In terms of mass fraction, it contains: mixed nicotine salt 1-20%, cellulose 55-70%, flavoring agent 1-15%, moisturizer 1-5%, antioxidant 1-5%; mixed nicotine salt is liquid Nicotine-benzoate, solid nicotine-tartrate, solid nicotine-alginate mixture.
混合尼古丁盐中，液体尼古丁-苯甲酸盐占混合尼古丁盐质量分数的8-15％，固体尼古丁-酒石酸盐占混合尼古丁盐质量分数的30-40％，固体尼古丁-海藻酸盐占混合尼古丁盐质量分数的50-60％。In the mixed nicotine salt, the liquid nicotine-benzoate accounts for 8-15% of the mass fraction of the mixed nicotine salt, the solid nicotine-tartrate accounts for 30-40% of the mixed nicotine salt, and the solid nicotine-alginate accounts for the mixed nicotine 50-60% of the salt mass fraction.
纤维素选自天然纤维、微晶纤维素、纤维素衍生物中的至少一种。The cellulose is at least one selected from natural fibers, microcrystalline cellulose, and cellulose derivatives.
矫味剂选自单糖、二糖、三糖、多糖、多元醇、增甜剂中的至少一种。The flavoring agent is selected from at least one of monosaccharides, disaccharides, trisaccharides, polysaccharides, polyalcohols and sweeteners.
保润剂选自丙二醇、丙三醇中的至少一种。The humectant is selected from at least one of propylene glycol and glycerin.
抗氧化剂选自维生素A、维生素C、维生素E中的至少一种。The antioxidant is selected from at least one of vitamin A, vitamin C, and vitamin E.
优选的，还包括酸碱调节剂和氯化钠，酸碱调节剂的质量分数为1-5％，选自碳酸氢钠、碳酸钠中的至少一种；氯化钠的质量分数为3-5％。Preferably, also include acid-base regulator and sodium chloride, the massfraction of acid-base regulator is 1-5%, is selected from at least one in sodium bicarbonate, sodium carbonate; The massfraction of sodium chloride is 3-5%. 5%.
优选的，还包括余量的水。Preferably, a balance of water is also included.
一种尼古丁缓释型口含烟的制备方法，A preparation method of nicotine sustained-release snus,
包含以下步骤：Contains the following steps:
混合，将混合尼古丁盐、纤维素、保润剂混合，得到第一混合物；mixing, mixing the mixed nicotine salt, cellulose, and humectant to obtain the first mixture;
加热，对第一混合物进行烘烤和加热处理，然后加入水、氯化钠和酸碱调节剂混合后冷藏，得到第二混合物；heating, toasting and heat-treating the first mixture, then adding water, sodium chloride and an acid-base regulator, mixing and then refrigerating to obtain the second mixture;
杀菌，在第二混合物上添加矫味剂、抗氧化剂，密封冷藏后杀菌处理，得到尼古丁缓释型口含烟。Sterilization, adding flavoring agents and antioxidants to the second mixture, sealing and refrigerating, and then sterilizing to obtain nicotine sustained-release snus.
具体的，包含以下步骤：Specifically, the following steps are included:
混合，备料，将混合尼古丁盐、纤维素、保润剂混匀过筛后，取粒度20目的粉粒混合均匀，得到第一混合物；Mixing, preparing materials, mixing and sieving the mixed nicotine salt, cellulose, and humectant, taking powder particles with a particle size of 20 mesh and mixing evenly to obtain the first mixture;
加热，对第一混合物进行烘烤和加热处理，然后加入水、氯化钠和酸碱调节剂混合均匀后冷藏，得到第二混合物；所述加热处理可选用巴氏消毒锅加热处理；冷藏时间优选为10-14h，更优选的为12h；Heating, toasting and heat treatment of the first mixture, then adding water, sodium chloride and acid-base regulator and mixing uniformly and then refrigerating to obtain the second mixture; the heat treatment can be heat treatment in a pasteurizer; the refrigerating time Preferably 10-14h, more preferably 12h;
杀菌，在第二混合物上添加矫味剂、抗氧化剂，密封冷藏后杀菌处理，得到尼古丁缓释型口含烟；密封冷藏时间优选为22-26h，更优选的为24h；杀菌可选为紫外杀菌，杀菌时间优选为2-4h，更优选的为3h。Sterilization, add flavoring agents and antioxidants to the second mixture, seal and refrigerate, and then sterilize to obtain nicotine slow-release snus; the time for sealing and refrigerating is preferably 22-26h, more preferably 24h; the sterilization can be ultraviolet Sterilization, the sterilization time is preferably 2-4h, more preferably 3h.
实施例1Example 1
该尼古丁缓释型口含烟由下述质量百分数的原料混匀后制成：The nicotine slow-release snus is made by mixing the following raw materials in mass percentage:
混合尼古丁盐5％、微晶纤维素65％、丙二醇5％；将物料混匀过筛后，取粒度20目的粉粒混合均匀，分别通过烘烤和巴氏消毒锅加热处理后，加入水余量、氯化钠3％、碳酸钠2％，掺配均匀，冷藏12小时，喷施蜂蜜4％、葡萄糖4％、阿巴斯甜1％、维生素E1％，密封冷藏24小时，经紫外杀菌3小时，分装即为成品。
混合尼古丁盐中各组分的优选配比按质量计为：液体尼古丁-苯甲酸盐8％、固体尼古丁-酒石酸盐34％、固体尼古丁-海藻酸58％。The preferred ratio of components in the mixed nicotine salt is: 8% liquid nicotine-benzoate, 34% solid nicotine-tartrate and 58% solid nicotine-alginic acid.
实施例2Example 2
该尼古丁缓释型口含烟由下述质量百分数的原料混匀后制成：The nicotine slow-release snus is made by mixing the following raw materials in mass percentage:
混合尼古丁盐7％、微晶纤维素61％、丙二醇4％；将物料混匀过筛后，取粒度20目的粉粒混合均匀，分别通过烘烤和巴氏消毒锅加热处理后，加入水余量、氯化钠3％、碳酸钠2％，掺配均匀，冷藏12小时，喷施蜂蜜3％、葡萄糖4％、阿巴斯甜2％、维生素E1％，密封冷藏24小时，经紫外杀菌3小时，分装即为成品。
混合尼古丁盐中各组分的优选配比按质量计为：液体尼古丁-苯甲酸盐12％、固体尼古丁-酒石酸盐36％、固体尼古丁-海藻酸52％。The preferred ratio of components in the mixed nicotine salt is as follows: liquid nicotine-benzoate 12%, solid nicotine-tartrate 36%, solid nicotine-alginic acid 52%.
实施例3Example 3
该尼古丁缓释型口含烟由下述质量百分数的原料混匀后制成：The nicotine slow-release snus is made by mixing the following raw materials in mass percentage:
混合尼古丁盐6％、微晶纤维素63％、丙二醇5％；将物料混匀过筛后，取粒度20目的粉粒混合均匀，分别通过烘烤和巴氏消毒锅加热处理后，加入水余量、氯化钠3％、碳酸钠2％，掺配均匀，冷藏12小时，喷施蜂蜜3％、葡萄糖4％、阿巴斯甜2％、维生素E1％，密封冷藏24小时，经紫外杀菌3小时，分装即为成品。
混合尼古丁盐中各组分的优选配比按质量计为：液体尼古丁-苯甲酸盐13％、固体尼古丁-酒石酸盐32％、固体尼古丁-海藻酸55％。The preferred proportioning ratio of each component in the mixed nicotine salt is: liquid nicotine-benzoate 13%, solid nicotine-tartrate 32%, solid nicotine-alginic acid 55%.
实施例4Example 4
该尼古丁缓释型口含烟由下述质量百分数的原料混匀后制成：The nicotine slow-release snus is made by mixing the following raw materials in mass percentage:
混合尼古丁盐20％、天然纤维55％、丙三醇5％；将物料混匀过筛后，取粒度20目的粉粒混合均匀，分别通过烘烤和巴氏消毒锅加热处理后，加入水余量、氯化钠3％、碳酸氢钠5％，掺配均匀，冷藏12小时，喷施蜂蜜1％、葡萄糖2％、阿巴斯甜1％、维生素C1％，密封冷藏24小时，经紫外杀菌3小时，分装即为成品。Mix 20% of nicotine salt, 55% of natural fiber, and 5% of glycerin; after the materials are mixed and sieved, the powder particles with a particle size of 20 mesh are mixed evenly, and after being baked and heat-treated in a pasteurizer, water is added 3% sodium chloride, 5% sodium bicarbonate, mixed evenly, refrigerated for 12 hours, sprayed
混合尼古丁盐中各组分的优选配比按质量计为：液体尼古丁-苯甲酸盐8％、固体尼古丁-酒石酸盐32％、固体尼古丁-海藻酸60％。The preferred ratio of components in the mixed nicotine salt is: 8% liquid nicotine-benzoate, 32% solid nicotine-tartrate and 60% solid nicotine-alginic acid.
实施例5Example 5
该尼古丁缓释型口含烟由下述质量百分数的原料混匀后制成：The nicotine slow-release snus is made by mixing the following raw materials in mass percentage:
混合尼古丁盐3％、微晶纤维素63％、纤维素衍生物7％，丙二醇1％，丙三醇1％；将物料混匀过筛后，取粒度20目的粉粒混合均匀，分别通过烘烤和巴氏消毒锅加热处理后，加入水余量、氯化钠5％、碳酸钠5％，掺配均匀，冷藏12小时，喷施蜂蜜3％、葡萄糖4％、阿巴斯甜2％、维生素E2％，维生素A3％，密封冷藏24小时，经紫外杀菌3小时，分装即为成品。
混合尼古丁盐中各组分的优选配比按质量计为：液体尼古丁-苯甲酸盐15％、固体尼古丁-酒石酸盐35％、固体尼古丁-海藻酸40％。The preferred ratio of components in the mixed nicotine salt is: 15% of liquid nicotine-benzoate, 35% of solid nicotine-tartrate and 40% of solid nicotine-alginic acid.
同时根据实施例1设置对比例，对比例与实施例1的区别如下表1所示。Meanwhile, a comparative example is set according to Example 1, and the difference between the Comparative Example and Example 1 is shown in Table 1 below.
表1对比例与实施例1的区别The difference between the comparative example of table 1 and
将实施例和对比例制备的口含烟，放入50ml pH值为8.1的磷酸缓冲液中，按实验设计时间取样检测，从而得到尼古丁缓释型口含烟的缓释度与时间的关系，进而制备尼古丁缓释型口含烟的释放曲线。其中，图1为实施例1-5的尼古丁缓释型口含烟的释放曲线；图2为对比例1-7的尼古丁缓释型口含烟的释放曲线。The snus prepared by the examples and the comparative examples was put into 50ml of phosphate buffer solution with a pH value of 8.1, and the sampling time was tested according to the experimental design, so as to obtain the slow-release degree of the nicotine slow-release snus and the relationship between time, Then the release curve of nicotine sustained-release snus was prepared. Among them, Fig. 1 is the release curve of the nicotine slow-release snus of Examples 1-5; Fig. 2 is the release curve of the nicotine slow-release snus of Comparative Examples 1-7.
由图1-2可知，本发明的实施例1-5的尼古丁缓释型口含烟，从开始到8分钟内均匀释放尼古丁。而对比例中，尼古丁释放不均匀。It can be seen from Figures 1-2 that the nicotine slow-release snus of Examples 1-5 of the present invention releases nicotine uniformly from the beginning to 8 minutes. On the other hand, in the comparative example, the nicotine release was not uniform.
在上述实施例中，对各个实施例的描述都各有侧重，某个实施例中没有详细描述的部分，可以参见其他实施例的相关描述。In the foregoing embodiments, the descriptions of each embodiment have their own emphases, and for parts not described in detail in a certain embodiment, reference may be made to relevant descriptions of other embodiments.
以上所述仅为本发明的实施例，并非因此限制本发明的专利范围，凡是利用本发明说明书及附图内容所作的等效结构或等效流程变换，或直接或间接运用在其他相关的技术领域，均同理包括在本发明的专利保护范围。The above is only an embodiment of the present invention, and does not limit the patent scope of the present invention. Any equivalent structure or equivalent process transformation made by using the description of the present invention and the contents of the accompanying drawings, or directly or indirectly used in other related technologies fields, are all included in the scope of patent protection of the present invention in the same way.
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Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101437496A (en)* | 2006-03-16 | 2009-05-20 | 尼科诺瓦姆股份公司 | Chewing gum compositions providing rapid release of nicotine |
| US20100004294A1 (en)* | 2006-03-16 | 2010-01-07 | Niconovum Ab | Stable Lozenge Compositions Providing Rapid Release of Nicotine |
| US20110268809A1 (en)* | 2010-04-28 | 2011-11-03 | Paul Andrew Brinkley | Nicotine-Containing Pharmaceutical Compositions |
| CN111084410A (en)* | 2019-11-22 | 2020-05-01 | 云南中烟工业有限责任公司 | Preparation method and application of nicotine-oxalate compound crystal |
| CN114521669A (en)* | 2022-02-25 | 2022-05-24 | 深圳市元雾科技有限公司 | Nicotine-stabilized buccal tobacco product and preparation method thereof |
| US20220313679A1 (en)* | 2021-04-06 | 2022-10-06 | Altria Client Services Llc | Controlled-release nicotine chewing gum |
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Patent Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101437496A (en)* | 2006-03-16 | 2009-05-20 | 尼科诺瓦姆股份公司 | Chewing gum compositions providing rapid release of nicotine |
| US20100004294A1 (en)* | 2006-03-16 | 2010-01-07 | Niconovum Ab | Stable Lozenge Compositions Providing Rapid Release of Nicotine |
| US20110268809A1 (en)* | 2010-04-28 | 2011-11-03 | Paul Andrew Brinkley | Nicotine-Containing Pharmaceutical Compositions |
| CN111084410A (en)* | 2019-11-22 | 2020-05-01 | 云南中烟工业有限责任公司 | Preparation method and application of nicotine-oxalate compound crystal |
| US20220313679A1 (en)* | 2021-04-06 | 2022-10-06 | Altria Client Services Llc | Controlled-release nicotine chewing gum |
| CN114521669A (en)* | 2022-02-25 | 2022-05-24 | 深圳市元雾科技有限公司 | Nicotine-stabilized buccal tobacco product and preparation method thereof |
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