CN115743679A - Adsorbent resin filling device and filling process - Google Patents
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Abstract
Description
Translated fromChinese技术领域technical field
本申请涉及血液净化技术领域，尤其涉及一种吸附剂树脂灌装装置及灌装工艺。The present application relates to the technical field of blood purification, in particular to an adsorbent resin filling device and a filling process.
背景技术Background technique
血液净化技术是指将患者的血液引出身体外，并通过净化装置除去其中某些致病物质，再返回患者体内，实现净化血液以治疗疾病的技术。早期的进行性肾脏疾病，肾功能不足导致的肾衰竭、尿毒症等均可采用血液净化的技术进行治疗或缓解。Blood purification technology refers to the technology that takes the patient's blood out of the body, removes some pathogenic substances in it through a purification device, and then returns it to the patient's body to purify the blood to treat diseases. Early progressive kidney disease, renal failure caused by insufficient renal function, uremia, etc. can be treated or alleviated by blood purification technology.
随着技术的不断发展，近年来基于人工肾技术概念的血液灌流、血浆吸附、免疫吸附等血液净化治疗的范围不断扩大。血液灌流、血浆吸附等血液净化技术：通常采用血液或血浆与固相吸附剂接触，利用固相吸附剂吸附血液或血浆中有害物质后再将净化的血液回输患者体内。With the continuous development of technology, the range of blood purification treatments such as hemoperfusion, plasma adsorption, and immunoadsorption based on the concept of artificial kidney technology has been continuously expanded in recent years. Blood purification technologies such as hemoperfusion and plasma adsorption: Usually, blood or plasma is contacted with a solid-phase adsorbent, and the solid-phase adsorbent is used to absorb harmful substances in the blood or plasma, and then the purified blood is returned to the patient.
吸附剂材料一般采用树脂类载体，灌装于吸附柱内对血液或血浆进行处理。为避免使用时导致患者发生不良反应，吸附剂灌装时需要对微生物、内毒素等进行严格控制，并且要求无可见异物，无微小颗粒。因而吸附剂灌装无法采用完全机械灌装，目前多采用手动和机械灌装混合使用的方式，保证吸附剂颗粒不会破损，同时保证微生物、内毒素和可见异物不会超标。但是，该手动和机械灌装混合使用的方式，仍存在灌装效率低的问题。The adsorbent material generally adopts a resin carrier, which is filled in an adsorption column to process blood or plasma. In order to avoid adverse reactions in patients during use, strict control of microorganisms, endotoxins, etc. must be carried out during the filling of the adsorbent, and no visible foreign matter and tiny particles are required. Therefore, complete mechanical filling cannot be used for adsorbent filling. At present, a combination of manual and mechanical filling is used to ensure that the adsorbent particles will not be damaged, and at the same time ensure that microorganisms, endotoxins and visible foreign matter will not exceed the standard. However, the mixed use of manual and mechanical filling still has the problem of low filling efficiency.
吸附剂的装量同样影响吸附效果。如果吸附剂装量不足，吸附柱的吸附效果无法满足使用需求；而吸附剂装量过量，则容易因挤压造成吸附剂颗粒破碎，或者突破过滤膜，造成过滤膜破损而影响灌流器的正常使用。目前为实现精准装量，通常在吸附剂灌装前，增加一个定量装置，对吸附剂进行定量后再灌装入吸附柱内。操作过程繁琐，并且增加的步骤容易导致吸附剂的破损，从而影响吸附柱的灌装质量。The amount of adsorbent also affects the adsorption effect. If the amount of adsorbent is insufficient, the adsorption effect of the adsorption column cannot meet the needs of use; if the amount of adsorbent is excessive, it is easy to break the adsorbent particles due to extrusion, or break through the filter membrane, resulting in damage to the filter membrane and affecting the normal operation of the perfusion device. use. At present, in order to achieve accurate loading, a quantitative device is usually added before the adsorbent is filled, and the adsorbent is quantified and then filled into the adsorption column. The operation process is cumbersome, and the added steps are likely to cause damage to the adsorbent, thereby affecting the filling quality of the adsorption column.
发明内容Contents of the invention
有鉴于此，本申请的目的是提供一种吸附剂树脂灌装装置及灌装工艺，以解决背景技术中存在的技术问题。In view of this, the purpose of this application is to provide an adsorbent resin filling device and filling process to solve the technical problems existing in the background technology.
为达到上述技术目的，本申请提供了一种吸附剂树脂灌装装置，包括空气注入装置、预混罐、分装罐、缓冲液注入装置以及缓冲液罐；In order to achieve the above technical purpose, the application provides an adsorbent resin filling device, including an air injection device, a premix tank, a sub-package tank, a buffer injection device and a buffer tank;
所述分装罐分别与所述预混罐以及所述缓冲液罐连接导通，且所述分装罐设有与吸附柱连接的灌装口；The sub-package tank is respectively connected to the premix tank and the buffer tank, and the sub-package tank is provided with a filling port connected to the adsorption column;
所述空气注入装置与所述预混罐连接，用于往所述预混罐内注入空气；The air injection device is connected to the premix tank for injecting air into the premix tank;
所述缓冲液注入装置连接于所述分装罐与所述缓冲液罐之间，用于将所述缓冲液罐内的缓冲液注入所述分装罐内。The buffer injection device is connected between the sub-package tank and the buffer solution tank, and is used for injecting the buffer solution in the buffer solution tank into the sub-package tank.
进一步地，所述灌装口的口径不大于15mm。Further, the diameter of the filling port is not greater than 15mm.
进一步地，所述预混罐、所述分装罐以及所述缓冲液罐上均连接有用于连接灭菌设备的灭菌连接管。Further, the premixing tank, the subpackaging tank and the buffer tank are all connected with sterilization connecting pipes for connecting sterilization equipment.
进一步地，还包括液位检测器，所述液位检测器为电容液位检测器或光电液位传感器；Further, a liquid level detector is also included, and the liquid level detector is a capacitive liquid level detector or a photoelectric liquid level sensor;
所述液位检测器安装于所述分装罐顶部管路上，用于检测所述分装罐是否装满。The liquid level detector is installed on the pipeline at the top of the sub-package tank to detect whether the sub-package tank is full.
进一步地，所述分装罐底部呈倒锥状，且锥角为30°～120°。Further, the bottom of the dispensing tank is in the shape of an inverted cone, and the cone angle is 30°-120°.
进一步地，所述灌装口设于所述分装罐底部。Further, the filling port is located at the bottom of the dispensing tank.
进一步地，所述吸附柱底部安装有排液装置。Further, a liquid drainage device is installed at the bottom of the adsorption column.
进一步地，所述空气注入装置为空压机。Further, the air injection device is an air compressor.
进一步地，所述缓冲液注入装置为流量控制装置；Further, the buffer injection device is a flow control device;
所述流量控制装置包括控制器以及与所述控制器连接的计量泵，所述控制器用于基于体积计量法，控制所述计量泵往所述分装罐内注入预设体积的缓冲液；或The flow control device includes a controller and a metering pump connected to the controller, and the controller is used to control the metering pump to inject a preset volume of buffer solution into the sub-package tank based on a volumetric metering method; or
所述流量控制装置包括控制器、与所述控制器连接的计时器以及与所述控制器连接的恒流泵，所述控制器用于通过所述计时器，控制所述恒流泵往所述分装罐内注入预设时间的缓冲液。The flow control device includes a controller, a timer connected to the controller and a constant flow pump connected to the controller, and the controller is used to control the flow of the constant flow pump to the Fill the aliquot tank with the buffer solution for the preset time.
本申请还公开了一种应用于上述的吸附剂树脂灌装装置的灌装工艺，包括步骤：The application also discloses a filling process applied to the above-mentioned adsorbent resin filling device, comprising steps:
将预混罐中的树脂与缓冲液预混后，通过空气注入装置往预混罐内注入空气，以将所述预混罐内的预混料压入分装罐内；After premixing the resin in the premix tank with the buffer solution, inject air into the premix tank through the air injection device, so as to press the premix in the premix tank into the distribution tank;
将压入分装罐内的预混料静置预设时间后，通过缓冲液注入装置将缓冲液罐内的缓冲液注入所述分装罐内至注满所述分装罐；After the premixed material pressed into the sub-package tank is left to stand for a preset time, the buffer solution in the buffer solution tank is injected into the sub-package tank through the buffer solution injection device until the sub-package tank is full;
在所述分装罐密闭状态下打开所述分装罐的灌装口，以排出所述分装罐内的部分混合料，使得所述分装罐达到负压自平衡状态；Open the filling port of the sub-package tank in the sealed state of the sub-package tank to discharge part of the mixture in the sub-package tank, so that the sub-package tank reaches a negative pressure self-balance state;
通过缓冲液注入装置将缓冲液罐内的缓冲液按预设量注入所述分装罐内，以将所述分装罐内的待灌装物料按预设量压入吸附柱。The buffer solution in the buffer solution tank is injected into the sub-package tank according to a preset amount through the buffer solution injection device, so as to press the material to be filled in the sub-package tank according to a preset amount into the adsorption column.
从以上技术方案可以看出，本申请所设计的吸附剂树脂灌装装置，分别通过空气置换以及缓冲液置换的方式来进行待灌装物料的输送，无需使用机械阀或电磁阀，避免了这些阀装置挤压树脂而导致树脂破损，而且上述设计可以实现全自动灌装，无需人工操作，进一步提升了灌装效率。再者，将预混罐与分装罐联用，先在预混罐内进行缓冲液与树脂的预混，再将预混后的预混料输送至分装罐内进行静置，即使输送过程中预混料存在夹杂气泡情况，也能通过在分装罐进行静置沉降以将气泡排除。It can be seen from the above technical solutions that the adsorbent resin filling device designed in this application transports the materials to be filled through air replacement and buffer replacement respectively, without using mechanical valves or solenoid valves, avoiding these problems. The valve device squeezes the resin to cause resin damage, and the above design can realize automatic filling without manual operation, which further improves the filling efficiency. Furthermore, the premixing tank is used in combination with the subpackaging tank, the buffer solution and the resin are premixed in the premixing tank first, and then the premixed premixed material is transported to the subpackaging tank for standing still, even if it is transported During the process, there are air bubbles in the premix, and the air bubbles can also be eliminated by standing and settling in the sub-packaging tank.
附图说明Description of drawings
为了更清楚地说明本申请实施例或现有技术中的技术方案，下面将对实施例或现有技术描述中所需要使用的附图作简单地介绍，显而易见地，下面描述中的附图仅仅是本申请的一些实施例，对于本领域普通技术人员来讲，在不付出创造性劳动性的前提下，还可以根据这些附图获得其它的附图。In order to more clearly illustrate the technical solutions in the embodiments of the present application or the prior art, the following will briefly introduce the drawings that need to be used in the description of the embodiments or the prior art. Obviously, the accompanying drawings in the following description are only These are some embodiments of the present application. Those skilled in the art can also obtain other drawings based on these drawings without any creative effort.
图1为本申请中提供的一种吸附剂树脂灌装装置的结构示意图；Fig. 1 is the structural representation of a kind of adsorbent resin filling device provided in the present application;
图2为本申请中提供的一种灌装工艺的流程图；Fig. 2 is a flow chart of a filling process provided in the present application;
图中：1、预混罐；2、分装罐；21、灌装口；3、缓冲液注入装置；4、缓冲液罐；51、第一连接管；52、第二连接管；61、空气输入管；62、第一输出管；63、第二输出管；64、压力控制器；7、灭菌连接管；71、SIP连接管；72、CIP连接管；8、吸附柱；9、可拆卸连接口；10、液位检测器；k1、第一开关阀；k2、第二开关阀；k4、第四开关阀；k5、第五开关阀；k6、第六开关阀；k7、第七开关阀。In the figure: 1. Premixing tank; 2. Dispensing tank; 21. Filling port; 3. Buffer injection device; 4. Buffer tank; 51. First connecting pipe; 52. Second connecting pipe; 61. Air input pipe; 62. First output pipe; 63. Second output pipe; 64. Pressure controller; 7. Sterilization connecting pipe; 71. SIP connecting pipe; 72. CIP connecting pipe; 8. Adsorption column; 9. Detachable connection port; 10, liquid level detector; k1, first on-off valve; k2, second on-off valve; k4, fourth on-off valve; k5, fifth on-off valve; k6, sixth on-off valve; k7, second on-off valve Seven switching valves.
具体实施方式Detailed ways
下面将结合附图对本申请实施例的技术方案进行清楚、完整地描述，显然，所描述的实施例是本申请实施例一部分实施例，而不是全部的实施例。基于本申请实施例中的实施例，本领域普通技术人员在没有做出创造性劳动前提下所获得的所有其他实施例，都属于本申请实施例保护的范围。The following will clearly and completely describe the technical solutions of the embodiments of the present application with reference to the accompanying drawings. Apparently, the described embodiments are part of the embodiments of the present application, not all of them. Based on the embodiments in the embodiments of the present application, all other embodiments obtained by persons of ordinary skill in the art without making creative efforts belong to the protection scope of the embodiments of the present application.
在本申请实施例的描述中，需要说明的是，术语“中心”、“上”、“下”、“左”、“右”、“竖直”、“水平”、“内”、“外”等指示的方位或位置关系为基于附图所示的方位或位置关系，仅是为了便于描述本申请实施例和简化描述，而不是指示或暗示所指的装置或元件必须具有特定的方位、以特定的方位构造和操作，因此不能理解为对本申请实施例的限制。此外，术语“第一”、“第二”、“第三”仅用于描述目的，而不能理解为指示或暗示相对重要性。In the description of the embodiments of the present application, it should be noted that the terms "center", "upper", "lower", "left", "right", "vertical", "horizontal", "inner", "outer " and other indicated orientations or positional relationships are based on the orientations or positional relationships shown in the drawings, and are only for the convenience of describing the embodiments of the present application and simplifying the description, rather than indicating or implying that the referred device or element must have a specific orientation, Constructed and operative in a particular orientation and therefore should not be construed as limiting to the embodiments of the present application. In addition, the terms "first", "second", and "third" are used for descriptive purposes only, and should not be construed as indicating or implying relative importance.
在本申请实施例的描述中，需要说明的是，除非另有明确的规定和限定，术语“安装”、“相连”、“连接”应做广义理解，例如，可以是固定连接，也可以是可更换连接，或一体地连接，可以是机械连接，也可以是电连接，可以是直接相连，也可以通过中间媒介间接相连，可以是两个元件内部的连通。对于本领域的普通技术人员而言，可以具体情况理解上述术语在本申请实施例中的具体含义。In the description of the embodiments of this application, it should be noted that unless otherwise specified and limited, the terms "installation", "connection", and "connection" should be understood in a broad sense, for example, it can be a fixed connection or a Replaceable connection, or integral connection, can be mechanical connection or electrical connection, direct connection or indirect connection through an intermediary, or internal communication between two components. Those of ordinary skill in the art can understand the specific meanings of the above terms in the embodiments of the present application in specific situations.
本申请实施例公开了一种吸附剂树脂灌装装置。The embodiment of the present application discloses an adsorbent resin filling device.
请参阅图1，本申请实施例中提供的一种吸附剂树脂灌装装置的一个实施例包括：Please refer to Fig. 1, an embodiment of a kind of adsorbent resin filling device provided in the embodiment of the present application comprises:
空气注入装置(图中未示)、预混罐1、分装罐2、缓冲液注入装置3以及缓冲液罐4。An air injection device (not shown in the figure), a premix tank 1 , a filling tank 2 , a buffer solution injection device 3 and a buffer solution tank 4 .
分装罐2通过第一连接管51与预混罐1连接导通，通过第二连接管52与缓冲液罐4连接导通，为了方便对分装罐2进行密闭控制，在第一连接管51上配置手动或电控的第一开关阀k1，在第二连接管52上配置有手动或电控的第二开关阀k2。The dispensing tank 2 is connected and conducted with the premix tank 1 through the first connecting
再者，分装罐2设有与吸附柱8连接的灌装口21，以实现通过灌装口21给吸附柱8进行灌装，该灌装口21上也设置有相应的手动或电控的第三开关阀(图中未示)。Furthermore, the filling tank 2 is provided with a filling
预混罐1上设有用于连接空气注入装置的空气输入管61，该空气输入管61上配置有手动或电控的第四开关阀k4，为了能够更好的控制预混罐1内的空气压力，在空气输入管61上还配置有压力控制器64用于控制空气的注入。空气注入装置通过空气输入管61与预混罐1连接，用于往预混罐1内注入空气。The premix tank 1 is provided with an
缓冲液注入装置3配置于第二连接管52上，用于将缓冲液罐4内的缓冲液注入分装罐2内。The buffer injection device 3 is arranged on the second connecting
从以上技术方案可以看出，本申请所设计的吸附剂树脂灌装装置，分别通过空气置换以及缓冲液置换的方式来进行树脂的输送，无需使用机械阀或电磁阀，避免了这些阀装置挤压树脂而导致树脂破损，而且上述设计可以实现全自动灌装，无需人工操作，进一步提升了灌装效率。再者，将预混罐1与分装罐2联用，先在预混罐1内进行缓冲液与树脂的预混，再将预混后的预混料输送至分装罐2内进行静置，即使输送过程中预混料存在夹杂气泡情况，也能通过在分装罐2进行静置沉降以将气泡排除。It can be seen from the above technical solutions that the adsorbent resin filling device designed in this application transports the resin through air replacement and buffer replacement respectively, without using mechanical valves or electromagnetic valves, and avoids the crowding of these valve devices. The resin is damaged due to pressing the resin, and the above design can realize automatic filling without manual operation, which further improves the filling efficiency. Furthermore, the premix tank 1 is used in combination with the subpackage tank 2, and the buffer solution and the resin are premixed in the premix tank 1 first, and then the premixed material is transported to the subpackage tank 2 for static Even if there are air bubbles in the premixed material during the transportation process, the air bubbles can be eliminated by standing and settling in the sub-packaging tank 2.
以上为本申请实施例提供的一种吸附剂树脂灌装装置的实施例一，以下为本申请实施例提供的一种吸附剂树脂灌装装置的实施例二，具体请参阅图1。The above is the first embodiment of the adsorbent resin filling device provided by the embodiment of the present application, and the following is the second embodiment of the adsorbent resin filling device provided by the embodiment of the present application, please refer to FIG. 1 for details.
基于上述实施例一的方案：Based on the scheme of the first embodiment above:
进一步地，灌装口21的口径优选设计为不大于15mm。这样可以保证树脂在灌装口21处的流速适宜，在整体灌装过程中不会受到较大机械力的影响，不会产生破损，形成微小颗粒。Further, the diameter of the filling
进一步地，预混罐1、分装罐2以及缓冲液罐4上均连接有用于连接灭菌设备的灭菌连接管7。该灭菌设备包括CIP灭菌设备和/或SIP灭菌设备，因此，灭菌连接管7也即包括CIP连接管72和/或SIP连接管71。通过与灭菌设备连接，可以根据要求在线进行消毒，减少细菌、霉素混入风险。预混罐1、分装罐2、缓冲罐均可以是在顶部连接CIP连接管72以及SIP连接管71，且CIP连接管72以及SIP连接管71均配置有手动或电控的第五开关阀k5。预混罐1底部设有第一输出管62，该第一连接管51的一端连接至该第一输出管62，而该第一输出管62上与第一连接管51连接的连接处两侧分别配置有手动或电控的第六开关阀k6，缓冲液罐4底部连接有第二输出管63，第二连接管52的一端连接至该第二输出管63，而该第二输出管63上与第二连接管52连接的连接处两侧均配置有手动或电控的第七开关阀k7。Further, the premixing tank 1 , the dispensing tank 2 and the buffer tank 4 are all connected with a sterilizing connecting pipe 7 for connecting the sterilizing equipment. The sterilizing equipment includes CIP sterilizing equipment and/or SIP sterilizing equipment, therefore, the sterilizing connecting pipe 7 also includes a
进一步地，该灌装口21根据需要可以亦可与具有可拆卸连接口9的灭菌设备连接。Further, the filling
进一步地，还包括液位检测器10，该液位检测器10可以为电容液位检测器或光电液位检测器；该液位检测器安装于分装罐2顶部管路上，用于检测分装罐2是否装满。以分装罐2顶部连接有SIP连接管71或CIP连接管72为例，那么该液位检测器10可以配置在分装罐2上连接的SIP连接管71或CIP连接管72上，以配置在SIP连接管71为例，在SIP连接管71上的第五开关阀k5可以是两个，分别配置在液位感应器10的两侧。Further, it also includes a
进一步地，该分装罐2底部优选设计呈倒锥状，且锥角可以为30°～120°，这一设计能更好实现分装罐2内的物料排出。以此为例，该灌装口21也即可以设于分装罐2底部。Further, the bottom of the dispensing tank 2 is preferably designed to be in an inverted cone shape, and the cone angle can be 30°-120°. This design can better realize the discharge of materials in the dispensing tank 2 . Taking this as an example, the filling
进一步地，吸附柱8底部安装有排液装置，可以将吸附柱8中多余的液体排出，该排液装置可以是带有相应开关阀的排液管，具体不做限制。Further, a liquid discharge device is installed at the bottom of the adsorption column 8 to discharge excess liquid in the adsorption column 8. The liquid discharge device may be a liquid discharge pipe with a corresponding switch valve, which is not specifically limited.
进一步地，空气注入装置优选设计为空压机。Further, the air injection device is preferably designed as an air compressor.
进一步地，缓冲液注入装置3优选设计为流量控制装置。该流量控制装置可以根据需要采用市面上已有的流量控制器进行使用。该流量控制装置具体可包括控制器以及与控制器连接的计量泵；该控制器采用体积计量法控制注入的流量，即控制器控制计量泵往分装罐2内注入缓冲液，当注入的缓冲液体积累计到达预设体积时，即视为满足设定的缓冲液量，停止注入。该流量控制装置还可包括控制器、与控制器连接的计时器以及与控制器连接的恒流泵；该控制器通过计时器控制恒流泵往分装罐2内注入缓冲液的时间，在达到预设时间时，即可视为满足设定的缓冲液量，停止注入。可以理解的是，该流量控制装置可以基于体积计量方式或恒流计时方式来实现缓冲液注入量的控制。Further, the buffer injection device 3 is preferably designed as a flow control device. The flow control device can be used as required by existing flow controllers on the market. The flow control device may specifically include a controller and a metering pump connected to the controller; the controller uses a volume metering method to control the injected flow, that is, the controller controls the metering pump to inject buffer into the sub-package tank 2, when the injected buffer When the liquid accumulator reaches the preset volume, it is deemed that the set buffer volume is met, and the injection is stopped. The flow control device can also include a controller, a timer connected with the controller and a constant flow pump connected with the controller; When the preset time is reached, it can be deemed that the set buffer volume is met, and the injection is stopped. It can be understood that the flow control device can realize the control of the injection amount of the buffer solution based on a volume metering method or a constant flow timing method.
总的来说，本申请所设计的吸附剂树脂灌装装置具有如下优点：In general, the adsorbent resin filling device designed by the present application has the following advantages:
1、可以实现吸附剂树脂的全自动灌装，无需人工操作，缩短操作时间，同时预混罐1、分装罐2、缓冲液罐4、灌装口21均可与灭菌设备连接，进而可以根据要求在线消毒，减少细菌、毒素混入风险。1. Fully automatic filling of adsorbent resin can be realized without manual operation, and the operation time is shortened. At the same time, the premix tank 1, sub-fill tank 2, buffer tank 4, and filling
2、缓冲液罐4通过流量控制装置控制进入分装罐2的缓冲液量，从而控制分装罐2装入吸附柱8的吸附剂量，实现吸附剂的精准装量。而且可利用分装罐2进行静置操作，使得树脂一直沉降在分装罐2底部，从灌装口21排出的固液混合料具有稳定的固含量，保证连续灌装固含量波动在3％以内。2. The buffer tank 4 controls the amount of buffer solution entering the sub-packaging tank 2 through the flow control device, thereby controlling the amount of adsorbent loaded into the adsorption column 8 by the sub-packaging tank 2, so as to realize the precise loading of the adsorbent. Moreover, the dispensing tank 2 can be used for static operation, so that the resin has been settled at the bottom of the dispensing tank 2, and the solid-liquid mixture discharged from the filling
3、预混料从预混罐1通过空压机直接泵入分装罐2，同时分装罐2的灌装口21在装过程中无阀门密封，通过密闭保持负压自平衡密封，灌装口21的口径不高于15mm，流速适宜，预混料中的树脂在整个灌装过程中均未受到较大机械力的影响，不会产生破损，形成微小颗粒。3. The premix is directly pumped from the premix tank 1 into the sub-package tank 2 through the air compressor. At the same time, the filling
4、分装罐2充满缓冲液时，保持密闭并无空气残留；缓冲液进入分装罐2时如有气泡也会直接上浮，减少灌装过程中吸附柱8内混入气泡的风险。4. When the sub-package tank 2 is filled with buffer solution, keep it airtight without air residue; when the buffer solution enters the sub-package tank 2, if there are bubbles, it will directly float up, reducing the risk of air bubbles mixed into the adsorption column 8 during the filling process.
如图2所示，本申请还公开了一种应用于上述实施例的吸附剂树脂灌装装置的灌装工艺，包括步骤：As shown in Figure 2, the present application also discloses a filling process applied to the adsorbent resin filling device of the above embodiment, including steps:
S1，将预混罐1中的树脂与缓冲液预混后，通过空气注入装置往预混罐1内注入空气，以将预混罐1内的预混料压入分装罐2内。需说明的是，通过往预混罐1内加入缓冲液以及树脂实现预混。S1, after premixing the resin and buffer solution in the premix tank 1, inject air into the premix tank 1 through the air injection device, so as to press the premix in the premix tank 1 into the dispensing tank 2. It should be noted that the premixing is realized by adding buffer solution and resin into the premixing tank 1 .
S2，将压入分装罐2内的预混料静置预设时间后，通过缓冲液注入装置3将缓冲液罐4内的缓冲液注入分装罐2内至注满分装罐2。需要说明的是，以具有液位传感器为例，那么往分装罐2内注入缓冲液至触发液位传感器时，即可视为注满，停止注液。S2, after the premixed material pressed into the dispensing tank 2 is left to stand for a preset time, the buffer solution in the buffer solution tank 4 is injected into the dispensing tank 2 through the buffer solution injection device 3 until the dispensing tank 2 is fully filled. It should be noted that, taking a liquid level sensor as an example, when the buffer solution is injected into the dispensing tank 2 until the liquid level sensor is triggered, it can be regarded as full and the liquid injection stops.
S3，在分装罐2密闭状态下打开分装罐2的灌装口21，以排出分装罐2内的部分混合料，使得分装罐2达到负压自平衡状态。需要说明的，当分装罐2达到负压自平衡状态时，其灌装口21也就不会再滴漏。S3, open the filling
S4，通过缓冲液注入装置3将缓冲液罐4内的缓冲液按预设量注入分装罐2内，以将分装罐2内的待灌装物料按预设量压入吸附柱8。需要说明的是，利用缓冲液注入控制按预设量定量地控制往分装罐2内的缓冲液注入，缓冲液注入的同时，灌装口21排出同体积的物料进入吸附柱8，以实现置换式灌装，缓冲液注入停止时，灌装口21也就停止灌装。S4, the buffer solution in the buffer solution tank 4 is injected into the filling tank 2 according to a preset amount through the buffer solution injection device 3, so as to press the material to be filled in the filling tank 2 into the adsorption column 8 according to a preset amount. It should be noted that the buffer injection control is used to quantitatively control the buffer injection into the sub-package tank 2 according to the preset amount. At the same time as the buffer injection, the filling
重复上述步骤S1-S4直至分装罐2内的树脂料消耗完成。Repeat the above steps S1-S4 until the consumption of the resin material in the dispensing tank 2 is completed.
以上对本申请所提供的一种吸附剂树脂灌装装置及灌装工艺进行了详细介绍，对于本领域的一般技术人员，依据本申请实施例的思想，在具体实施方式及应用范围上均会有改变之处，综上所述，本说明书内容不应理解为对本申请的限制。A kind of adsorbent resin filling device and filling process provided by this application have been introduced in detail above. For those of ordinary skill in the art, according to the ideas of the embodiments of this application, there will be some specific implementation methods and application ranges. Changes, in summary, the contents of this specification should not be construed as limiting the application.
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