Disclosure of Invention
The invention provides a compound field stimulation device with a magnetic guide module and an operation method thereof, which are used for improving the electrical stimulation intensity of a part to be treated and improving the treatment effect.
In a first aspect, an embodiment of the present invention provides a composite field stimulation device with a magnetic guidance module, including:
the ultrasonic wave transmitting module is used for transmitting ultrasonic wave beams to a part to be treated of the object to be treated;
the alternating magnetic field emission module is used for emitting electromagnetic wave beams to the to-be-treated part;
The liquid magnetic guiding module is arranged at the part to be treated and comprises liquid metal and magnetic particles;
the liquid magnetic guiding module enrichment module is used for guiding the liquid magnetic guiding module to flow to the part to be treated;
wherein, the included angle between the ultrasonic wave beam and the electromagnetic wave beam at the part to be treated is more than 0 degree.
Optionally, the liquid metal comprises gallium or gallium-based liquid metal.
Optionally, the magnetic particles comprise magnetic Fe3O4 nanoparticles.
Optionally, an included angle between the ultrasonic wave beam and the electromagnetic wave beam at the to-be-treated part is 90 degrees.
Optionally, the enrichment module of the liquid magnetic guiding module comprises a static magnet and a guiding bracket, wherein the static magnet is fixed on the guiding bracket, and the guiding bracket is used for adjusting the position and the orientation of the static magnet.
Optionally, the ultrasonic transmitting module includes a focused ultrasonic transducer and a pulsed ultrasonic excitation source for providing excitation to the focused ultrasonic transducer.
Optionally, the ultrasonic transmitting module further comprises a control part, and the control part adjusts the focal position of the focusing ultrasonic transducer by adjusting the output parameter of the pulse ultrasonic excitation source.
Optionally, the ultrasonic transmitting module further comprises a transducer bracket, the focused ultrasonic transducer is fixed on the transducer bracket, and the transducer bracket is used for adjusting the position and the orientation of the focused ultrasonic transducer.
Optionally, the transducer support includes a support body, a first sliding rail and a second sliding rail, the first sliding rail is mounted on the mounting surface along a first direction, the second sliding rail is mounted on the first sliding rail along a second direction, the second sliding rail can slide on the first sliding rail, and the support body can slide on the second sliding rail;
Wherein, the included angle formed by the first direction and the second direction is larger than 0 degree.
In a second aspect, an embodiment of the present invention further provides a method for operating a composite field stimulation device with a magnetic guidance module, where the method is operated on any one of the composite field stimulation devices with a magnetic guidance module, and the method includes:
injecting the liquid magnetic guiding module into the region where the part to be treated is located;
Controlling the liquid magnetic guiding module enrichment module to attach the magnet to the injection part of the liquid magnetic guiding module;
The magnet is enabled to move against the object to be treated by controlling the liquid magnetic guiding module enrichment module so as to guide the liquid magnetic guiding module in the object to be treated to flow and enrich to the part to be treated;
controlling the alternating magnetic field emission module to emit the electromagnetic wave beam to the part to be treated;
and controlling the ultrasonic wave transmitting module to transmit the ultrasonic wave beam to the to-be-treated part.
The composite field stimulation device with the magnetic guiding module in the embodiment of the invention transmits ultrasonic wave beams to a to-be-treated part of an object to be treated through the ultrasonic wave transmitting module, transmits the electromagnetic wave beams to the to-be-treated part through the alternating magnetic field transmitting module, wherein the liquid magnetic guiding module is arranged at the to-be-treated part and comprises liquid metal and magnetic particles, and the liquid magnetic guiding module is guided to flow to the to-be-treated part through the liquid magnetic guiding module enriching module, wherein an included angle formed between the ultrasonic wave beams and the electromagnetic wave beams at the to-be-treated part is larger than 0 degree. Because the vibration speed of liquid metal and magnetic particles in the liquid magnetic guiding module in ultrasonic waves is far greater than that of charged particles in biological tissues, the vibrating conductive particles are acted by Lorentz force in an alternating magnetic field, local induced current is formed in an ultrasonic focusing area, and the generated focused magnetoacoustic stimulation electric field is far greater than the induced current generated by the vibration of the charged particles in the biological tissues. Therefore, the intensity of the magnetoacoustic coupling focusing electric field is greatly improved, and the treatment effect is enhanced. By controlling the positions, the intensities and the postures of the ultrasonic wave beams and the electromagnetic wave beams, a composite field can be accurately formed at the part to be treated. And the intensity of the alternating magnetic field can be obviously higher than that of the static magnetic field, so that the intensity of the magnetoacoustic coupling electric field is further improved.
Detailed Description
The invention is described in further detail below with reference to the drawings and examples. It is to be understood that the specific embodiments described herein are merely illustrative of the invention and are not limiting thereof. It should be further noted that, for convenience of description, only some, but not all of the structures related to the present invention are shown in the drawings.
Transcranial magnetoacoustic coupling stimulation is a noninvasive electrical stimulation technique based on magnetoacoustic coupling effects of conductive tissues, and high spatial resolution is achieved by utilizing the high focusing characteristic of ultrasound. The basic principle is that conductive particles in a tissue are excited by ultrasound to generate vibration, and under the condition that a magnetic field (which can be an alternating magnetic field) perpendicular to the vibration direction of the particles exists, the conductive particles are acted by Lorentz force, and positive and negative particles are respectively deflected and converged towards two ends of the tissue along the vector product direction of the magnetic field and the ultrasound field to form an internal induction electric field. It can be seen that, for conductive biological tissue placed in a magnetic field, if an ultrasonic signal is injected in one direction, the internal coupling electric field and coupling current of the same frequency are generated in the direction perpendicular to the magnetic field and the sound field direction inside the tissue based on the magneto-acoustic coupling effect. The intensity of the induction electric field follows E=vj ×B, the vibration speeds vj of the particles of the induction electric field E and the coupling electric field and the magnetic induction intensity B of the magnetic field are all in linear relation, and the direction of the induction electric field is the vector product direction of the ultrasonic field and the magnetic field.
In an ideal pure medium, based on acoustic theory, the vibration velocity of particles in ultrasound is v=pρcm, where pultrasonic sound pressure, ρ is the medium density, and cm is the sound velocity in the medium, but in non-ideal biological tissues, the vibration velocity of actual charged particles, vj, is much smaller than the vibration velocity of the medium. Therefore, the strength of the induction electric field in the biological tissue is also smaller, and the treatment effect of the magnetoacoustic coupling electric stimulation is poorer.
Fig. 1 is a schematic structural diagram of a composite field stimulation device with a magnetic guiding module according to an embodiment of the present invention, see fig. 1. Based on the above-mentioned problems, an embodiment of the present invention provides a composite field stimulation device with a magnetic guiding module, including:
An ultrasonic wave transmitting module 1 for transmitting an ultrasonic wave beam to a treatment site of a subject to be treated;
An alternating magnetic field emission module 2 for emitting electromagnetic wave beams to the part to be treated;
A liquid magnetic guiding module (not shown in the figure), wherein the liquid magnetic guiding module is arranged at the part to be treated and comprises liquid metal and magnetic particles;
The liquid magnetic guiding module enrichment module 3 is used for guiding the liquid magnetic guiding module to flow to the part to be treated;
wherein, the included angle between the ultrasonic wave beam and the electromagnetic wave beam at the part to be treated is more than 0 degree.
The ultrasonic wave transmitting module 1 may be any device capable of transmitting ultrasonic waves to the portion to be treated. The embodiment of the present invention is not limited to a specific type of the ultrasonic wave transmitting module 1, and a specific example of the ultrasonic wave transmitting module 1 will be described hereinafter. The alternating magnetic field transmitting module 2 is capable of transmitting electromagnetic waves to a portion to be treated. Since the electromagnetic wave includes an alternating electric field and an alternating magnetic field, the alternating magnetic field can be constructed at the portion to be treated by means of the alternating magnetic field transmitting module 2 transmitting the electromagnetic wave to the portion to be treated. The alternating magnetic field emission module 2 can be any device capable of constructing an alternating magnetic field at a part to be treated, and the embodiment of the invention does not limit the specific structure of the alternating magnetic field emission module 2 and can meet the requirements. The part to be treated is human or animal body tissue requiring magneto-acoustic coupling electric field stimulation treatment, and the tissue can be brain tissue, any muscle or nerve tissue, and the intersection of ultrasonic wave beams and electromagnetic waves. The position to be treated can be changed by changing the pose of the ultrasonic wave transmitting module 1 and the alternating magnetic field transmitting module 2. The alternating magnetic field and the ultrasonic waves produce magnetoacoustic coupling to form an electric field at the site of the brain to be treated. The electric field strength and the electric field direction are the vector product of the ultrasonic wave and the alternating magnetic field. Therefore, it is necessary to ensure that the included angle between the ultrasonic wave beam and the electromagnetic wave beam at the treatment site is greater than 0 degrees. Preferably, the included angle between the ultrasonic wave beam and the electromagnetic wave beam at the part to be treated is 90 degrees. Thus, the maximum electric field intensity can be obtained, the current of the part to be treated is increased, and a better treatment effect is obtained. The liquid magnetic guiding module enrichment module 3 is used for guiding magnetic particles doped in the liquid metal to flow through a magnetic field after the liquid magnetic guiding module is injected near the part to be treated, and the magnetic particles drive the liquid metal to enrich the liquid magnetic guiding module in the part to be treated and position the liquid magnetic guiding module. The embodiment of the present invention is not limited to the specific structure of the liquid magnetic guiding module enrichment module 3, and the above requirements can be satisfied, and a liquid magnetic guiding module enrichment module 3 will be given below. In the above, the problem is mentioned that in non-ideal biological tissue, the vibration velocity of the actual charged particles is much smaller than that of the ideal pure medium. Since metals can be regarded as ideal pure media, the conductive particles have only electrons, the magnetoacoustic coupling electric field in metals is much greater than in biological tissues. By means of enriching liquid metal at the part to be treated, the biological tissue medium can be replaced by the liquid metal medium, so that the vibration speed of charged particles is improved, the intensity of magneto-acoustic coupling focusing electric field is greatly enhanced, and the treatment effect is enhanced.
In other embodiments, the liquid metal comprises gallium or gallium-based liquid metal.
The gallium alloy materials such as metal simple substance gallium, gallium indium tin zinc and the like have excellent physical and chemical properties, such as low melting point (lower than 300 ℃), high boiling point (higher than 1000 ℃), low viscosity, high surface tension, high heat conduction capability, wide metal dissolution capability, multiple responsiveness, natural two-dimensional nano oxide films on the surfaces and the like, and can reduce the influence of thermal effect and cavitation effect brought by ultrasound in transcranial magnetoacoustic coupling stimulation technology. And the simple substance gallium and the gallium alloy are nontoxic, and the liquid metal is the gallium alloy material. The material has stable physical and chemical properties, has better biocompatibility, and can not volatilize in air like mercury, thereby not directly damaging human beings. Related studies have shown that toxicity to human kidneys is only exhibited when gallium is administered at concentrations above 750 mg/kg. Therefore, the gallium or gallium-based liquid metal is selected as the enhancer of magneto-acoustic coupling stimulation, so that the magneto-acoustic coupling stimulation has higher safety.
In other embodiments, the magnetic particles comprise magnetic Fe3O4 nanoparticles.
Wherein, fe3O4 has no toxicity to human body and animal body, and has low price. The size of the magnetic Fe3O4 nano particles is not more than 100 nanometers, and the magnetic Fe3O4 nano particles are ideal as a material for guiding the flow enrichment of liquid metal.
In other embodiments, the liquid magnetic guide module enrichment module includes a static magnet 31 and a guide bracket 32, the static magnet being fixed to the guide bracket, the guide bracket being used to adjust the position and orientation of the static magnet.
Wherein the static magnet 31 may be located at an end of the guide bracket 32. When the magnetic field enrichment device is used, the guide bracket 32 can be adjusted to realize the movement of the space position and the adjustment of the magnetic field direction of the static magnetic field provided by the liquid magnetic guide module enrichment module 3. Thereby guiding the flow of the liquid magnetic guiding module and completing the positioning of the liquid magnetic guiding module. The embodiment of the present invention is not limited to the structure of the guide bracket 32, and any structure capable of satisfying the above-described requirements may be used as the guide bracket 32.
In other embodiments, the alternating magnetic field emission module 2 includes an alternating coil 21 and an alternating magnetic field exciter 23, the alternating magnetic field exciter 23 being configured to output an alternating current to the alternating coil 21.
Wherein the output of the alternating magnetic field exciter 23 is connected to the input of the alternating coil 21. The alternating coil 21 may have a circular structure or an 8-shaped structure, and may be formed by winding copper wires. Wherein the 8-shaped alternating coil 21 has better magnetic field focusing property. The alternating magnetic field exciter 23 may include a charging circuit, a storage capacitor, a pulse shaping circuit, a thyristor switch, etc. The alternating magnetic field exciter 23 is rectified by a high-voltage power supply, then charges an energy storage capacitor, charges and discharges the capacitor to obtain alternating current, and shapes and outputs the alternating current through a pulse shaping circuit. The alternating magnetic field exciter 23 can generate an alternating current of a certain repetition frequency and a certain pulse width, for example an alternating current of a pulse width of 280 mus at a repetition frequency of 1 Hz. The alternating coil 21 is excited to receive the alternating current, and based on the electromagnetic induction theory, the alternating coil 21 can generate a corresponding alternating magnetic field. For example an alternating magnetic field with a repetition frequency of 280 mus at 1 Hz.
In other embodiments, the ultrasound transmission module 1 comprises a focused ultrasound transducer 11 and a pulsed ultrasound excitation source 12, the pulsed ultrasound excitation source 12 being for providing excitation to the focused ultrasound transducer 11.
The focused ultrasound transducer 11 may be a single-array element focused ultrasound transducer or a phased array focused ultrasound transducer. The main frequency can be 0.3MHz-5MHz, and the frequency selection can be performed based on the stimulation depth of the object to be stimulated. The number of excitation channels of the pulsed ultrasonic excitation source 12 is consistent with the number of array elements of the focused ultrasonic transducer 11 to ensure that each channel can be excited individually for each array element.
In other embodiments, the ultrasound transmission module 1 further comprises a control section 13, the control section 13 adjusting the focal position of the focused ultrasound transducer 11 by adjusting the output parameters of the pulsed ultrasound excitation source 12.
Wherein when the focused ultrasound transducer 11 comprises a phased array focused ultrasound transducer, the focused ultrasound transducer 11 further comprises a control section 13. The control unit 13 may be a microcomputer or an industrial personal computer, and the excitation parameters of the excitation channels of the pulsed ultrasonic excitation source 12 are controlled by the microcomputer or the industrial personal computer. The excitation parameters may include excitation voltage, excitation pulse width, excitation frequency, and the like. The micro computer or industrial computer can regulate the pulse excitation parameters of each excitation channel to make the transducer send out focusing ultrasonic pulse signal with adjustable focal length and focus position. The pulsed ultrasonic excitation source 12 and microcomputer may be Verasonics ultrasonic development platforms.
In other embodiments, the ultrasound transmitting module 1 further includes a transducer holder 14, the focused ultrasound transducer 11 being fixed to the transducer holder 14, the transducer holder 14 being used to adjust the position and orientation of the focused ultrasound transducer 11. The alternating magnetic field emission module 2 includes an alternating coil 21 and a coil fixing bracket 22, the coil fixing bracket 22 being used to adjust the spatial position and orientation of the alternating coil 21.
The transducer support 14 may be any structure capable of adjusting the position and orientation of the focused ultrasound transducer 11, and the embodiment of the present invention is not limited to the specific structure of the transducer support 14. The coil fixing bracket 22 may be any structure capable of adjusting the position and orientation of the alternating coil 21, and embodiments of the present invention are not limited to the specific structure of the coil fixing bracket 22. By adjusting the coil fixing support 22 and the transducer support 14, the pose of the alternating coil 21 and the focusing ultrasonic transducer 11 is changed, so that the alternating magnetic field constructed by the alternating coil 21 and the ultrasonic wave emitted by the focusing ultrasonic transducer 11 intersect at any required position, and the alternating magnetic field and the ultrasonic wave can form a required angle, and the preferred angle is 90 degrees.
Fig. 2 is a schematic diagram of the operation of a composite field stimulation device with a magnetic guiding module according to an embodiment of the present invention, see fig. 2. At this time, the magnetoacoustic coupling electric field EMA in the same direction as the z-axis in the three-dimensional rectangular coordinate system can be generated in the vector product direction of the ultrasonic wave V in the same direction as the x-axis in the three-dimensional rectangular coordinate system and the alternating magnetic field B in the same direction as the y-axis in the three-dimensional rectangular coordinate system. Meanwhile, the alternating coil 21 can generate magnetic induction electric fields EM,EM and EMA which are in the same direction as the z axis in the three-dimensional rectangular coordinate system at the part to be treated of the brain, the intensity is overlapped, a composite physical field EM+EMA which is in the same direction is formed at the target area, the stimulation electric field intensity is further enhanced, and the original focusing ultrasonic field V in the orthogonal direction, namely in the same direction as the x axis in the three-dimensional rectangular coordinate system, can generate three physical fields of the magneto-acoustic coupling electric field EMA, the magnetic induction electric field EM and the focusing ultrasonic field V at the part to be treated of the brain, and the three physical fields form the composite field together to stimulate the brain.
In other embodiments, the transducer mount 14 includes a mount body 141, a first slide rail 142, and a second slide rail 143, the first slide rail 142 being mounted on the mounting surface in a first direction, the second slide rail 143 being mounted on the first slide rail 142 in a second direction, the second slide rail 143 being slidable on the first slide rail 142, the mount body 141 being slidable on the second slide rail 143;
Wherein, the included angle formed by the first direction and the second direction is larger than 0 degree.
The included angle between the first direction and the second direction may be 90 degrees, and the bracket body 141 may extend and retract in a direction perpendicular to the first direction and the second direction. One end of the bracket body 141 is connected with a focusing ultrasonic transducer 11 through a direction selector, and the focusing ultrasonic transducer 11 can change the direction relative to the bracket body 141. The spatial position of the focused ultrasound transducer 11 can be changed by the cooperation of the bracket body 141, the first slide rail 142, and the second slide rail 143.
In other embodiments, a subject fixation device 4 may be further included for fixing a subject.
The object fixing device 4 may include only a head fixing device, may include only a trunk fixing device, and may include both a head fixing device and a trunk fixing device. The head fixation device may be coupled to the torso fixation device. The trunk fixing device can be a primate fixing table or a seat. Wherein, the included angle formed by the first direction and the second direction is larger than 0 degree.
Fig. 3 is a flowchart of an operation method of a composite field stimulation device with a magnetic guiding module according to an embodiment of the present invention, see fig. 3. The embodiment of the invention also provides an operation method of the composite field stimulation device with the magnetic guiding module, which is operated in any one of the composite field stimulation devices with the magnetic guiding module in the embodiment, and comprises the following steps:
s1, injecting the liquid magnetic guiding module into the area where the part to be treated is located.
One or more of gallium-based liquid metals such as gallium, gallium indium tin zinc and the like can be used as a liquid metal part in the liquid magnetic guiding module, magnetic nano particles such as magnetic Fe3O4 nano particles are mixed into the liquid metal to form magnetic liquid metal, and the magnetic liquid metal is used as an enhancer to be injected into a part to be treated of a subject to be treated, for example, when the head is required to be treated, the magnetic liquid metal can be injected into the vicinity of an affected part of the head of the subject to be treated.
S2, controlling the liquid magnetic guiding module enrichment module to attach the magnet to the injection position of the liquid magnetic guiding module.
S3, enabling the magnet to move against the object to be treated by controlling the liquid magnetic guiding module enrichment module so as to guide the liquid magnetic guiding module in the body of the object to be treated to flow and enrich the liquid magnetic guiding module to the position to be treated.
The liquid magnetic guiding module enrichment module 3 is adjusted, static magnetic iron used for magnetic guiding in the liquid magnetic guiding module enrichment module 3 is clung to the head of an object to be treated, the liquid magnetic guiding module enrichment module 3 is continuously adjusted, and magnetic liquid metal in the static magnetic iron guiding body in the liquid magnetic guiding module enrichment module 3 is utilized to flow and enrich to the position to be treated, namely, the liquid magnetic guiding module is positioned at the position to be treated.
And S4, controlling the alternating magnetic field emission module to emit electromagnetic wave beams to the to-be-treated part.
And S5, controlling the ultrasonic wave transmitting module to transmit ultrasonic wave beams to the to-be-treated part.
Wherein if the alternating magnetic field emission module 2 comprises a coil fixing bracket 22, an alternating coil 21 and an alternating coil excitation device 23. The position and orientation of the alternating coil 21 can be adjusted by adjusting the coil fixing bracket 22. And the switch of the alternating coil excitation device 23 is turned on, and the alternating coil excitation device 23 excites the alternating coil 21 to emit electromagnetic waves, so that the alternating magnetic field is located at a portion to be treated of the object to be treated, for example, the portion to be treated may be the head of the object to be treated. The position of the focused ultrasound transducer 11 is adjusted so that the focused ultrasound transducer 11 can contact the scalp portion mapped to the brain region of the subject to be treated through the couplant and is orthogonal to the electromagnetic wave beam direction at that time. Then, the output parameters of the single-channel or multi-channel pulse ultrasonic excitation source 12 in the ultrasonic wave transmitting module 1 are adjusted, so that the focal length and the focal point of the ultrasonic transducer in the ultrasonic wave transmitting module 1 are aligned with the brain part to be treated of the object to be treated. At this time, the output of the pulse ultrasonic excitation source 12 is turned on, so that accurate transcranial magnetoacoustic stimulation can be performed on the brain position to be treated of the subject to be treated. The magnetic liquid metal is enhanced at the part to be treated, so that the magnetoacoustic coupling efficiency is greatly improved, and the intensity of the magnetoacoustic coupling electric field is greatly improved. In the stimulation, the sound pressure with different intensities can be realized by adjusting the size of ultrasonic excitation, so that the requirements of different stimulation intensities can be further obtained, and different magneto-acoustic stimulation directions can be realized by adjusting the relative positions of a focusing sound field and an alternating magnetic field. Realizing the treatment of the treatment part the stimulation direction is flexibly adjusted.
Note that the above is only a preferred embodiment of the present invention and the technical principle applied. It will be understood by those skilled in the art that the present invention is not limited to the particular embodiments described herein, and that various obvious changes, rearrangements, combinations, and substitutions can be made by those skilled in the art without departing from the scope of the invention. Therefore, while the invention has been described in connection with the above embodiments, the invention is not limited to the embodiments, but may be embodied in many other equivalent forms without departing from the spirit or scope of the invention, which is set forth in the following claims.