技术领域technical field
本发明涉及医用敷料(IPC分类号：A61K31/00)，尤其涉及一种一种强抗菌性的医用敷料及其制备方法。The invention relates to a medical dressing (IPC classification number: A61K31/00), in particular to a strong antibacterial medical dressing and a preparation method thereof.
背景技术Background technique
皮肤作为人体最重要的器官，在保护人体免受外部损伤和微生物入侵方面起着重要的作用。相比于急性伤口，慢性伤口的修复需要较长时间。慢性伤口如若长期未得到有效的处理，会影响患者的正常生活及工作等。在创面的修复过程中，微生物容易侵入伤口，并在伤口部位形成细菌菌落，从而导致严重的伤口感染。创面敷料是用于覆盖于伤口，可迅速止血，暂时保护伤口，控制或吸收伤口渗出液，屏蔽并抑制细的入侵有效手段之一。更重要的是，创面敷料最好对伤口的修复具有一定的促进作用，并使得伤口尽量没有疤痕。As the most important organ of the human body, the skin plays an important role in protecting the human body from external damage and microbial invasion. Chronic wounds take longer to heal than acute wounds. If the chronic wound is not treated effectively for a long time, it will affect the normal life and work of the patient. In the process of wound repair, microorganisms easily invade the wound and form bacterial colonies at the wound site, leading to severe wound infection. Wound dressing is one of the effective means used to cover wounds, quickly stop bleeding, temporarily protect wounds, control or absorb wound exudate, and shield and inhibit the invasion of bacteria. More importantly, the wound dressing is best to promote the repair of the wound to a certain extent, and make the wound as scar-free as possible.
专利申请CN201010149947.0公开一种纳米银功能性水胶体医用敷料的制备方法，该专利制备的医用敷料制备方法简单，可克服了银离子氧化后容易形成黑斑的弊端，但是，银类敷料虽具有明显的杀菌效果，但其生物安全性也存在较大隐患。Patent application CN201010149947.0 discloses a preparation method of nano-silver functional hydrocolloid medical dressing. The preparation method of the medical dressing prepared by the patent is simple, and can overcome the disadvantage of easy formation of dark spots after silver ion oxidation. However, although silver dressings It has obvious bactericidal effect, but its biological safety also has great hidden dangers.
因此，本发明制备的强抗菌性的医用敷料通过海洋活性生物提取物，阳离子抗菌剂的协同作用，极大程度地提高了医用敷料的抗菌效果，同时，选用的原料均为安全无毒副作用的材料，运用湿性愈合理论治疗创伤面能减轻疼痛和避免干痂形成，并形成湿润的愈合环境。大大缩短了伤口愈合的时间，降低了伤口污染和感染的发生，减少了护理人员工作量，显著提高了临床经济效益。Therefore, the strong antibacterial medical dressing prepared by the present invention greatly improves the antibacterial effect of the medical dressing through the synergistic effect of marine active biological extracts and cationic antibacterial agents. At the same time, the selected raw materials are all safe and non-toxic. Materials, using moist healing theory to treat the wound surface can reduce pain and avoid dry scab formation, and form a moist healing environment. The time for wound healing is greatly shortened, the occurrence of wound contamination and infection is reduced, the workload of nursing staff is reduced, and clinical economic benefits are significantly improved.
发明内容Contents of the invention
为了解决上述问题，本发明的第一方面提供了一种强抗菌性的医用敷料，按重量份计，原料至少包含：海洋活性生物提取物4～18份，多酚类化合物2～6份，低乙酰化壳聚寡糖2～8份，pH调节剂0.5～1份，纯化水8～15份，阳离子抗菌剂0.01～0.06份，辅料1～7份。In order to solve the above-mentioned problems, the first aspect of the present invention provides a medical dressing with strong antibacterial properties. In parts by weight, the raw materials at least include: 4-18 parts of marine active biological extracts, 2-6 parts of polyphenolic compounds, 2-8 parts of low acetylated chitosan oligosaccharide, 0.5-1 part of pH regulator, 8-15 parts of purified water, 0.01-0.06 parts of cationic antibacterial agent, and 1-7 parts of auxiliary materials.
作为一种优选的方案，按重量份计，原料至少包含：海洋活性生物提取物8～14份，多酚类化合物3～4份，低乙酰化壳聚寡糖3～5份，pH调节剂0.5～1份，纯化水8～15份，阳离子抗菌剂0.02～0.04份，辅料3～5份。As a preferred solution, in parts by weight, the raw materials at least include: 8 to 14 parts of marine active biological extracts, 3 to 4 parts of polyphenolic compounds, 3 to 5 parts of low acetylated chitosan oligosaccharides, pH regulator 0.5 to 1 part, 8 to 15 parts of purified water, 0.02 to 0.04 parts of cationic antibacterial agent, 3 to 5 parts of excipients.
作为一种优选的方案，所述海洋活性生物提取物为褐藻寡糖，卡拉胶寡糖，海藻活性肽的一种或多种。As a preferred solution, the marine active biological extract is one or more of fucoidan oligosaccharides, carrageenan oligosaccharides, and seaweed active peptides.
作为一种优选的方案，所述海洋活性生物提取物为褐藻寡糖，卡拉胶寡糖，海藻活性肽混合物。As a preferred solution, the marine active biological extract is a mixture of fucoidan oligosaccharides, carrageenan oligosaccharides, and seaweed active peptides.
作为一种优选方案，所述褐藻寡糖，卡拉胶寡糖，海藻活性肽中重量比为(1～5)：(1～5)：(3～7)。As a preferred solution, the weight ratio of the fucoidan oligosaccharides, carrageenan oligosaccharides and seaweed active peptides is (1-5):(1-5):(3-7).
作为一种优选方案，所述提取物为褐藻寡糖，卡拉胶寡糖，海藻活性肽中重量比为(2～4)：(2～4)：(4～6)。As a preferred embodiment, the extract is fucoidan oligosaccharide and carrageenan oligosaccharide, and the weight ratio of seaweed active peptide is (2-4):(2-4):(4-6).
作为一种优选的方案，所述褐藻寡糖，卡拉胶寡糖，海藻活性肽中重量比为3：3：5。As a preferred solution, the weight ratio of the fucoidan oligosaccharides, carrageenan oligosaccharides, and seaweed active peptides is 3:3:5.
作为一种优选的方案，所述褐藻寡糖的重均的分子量为4500～5500。As a preferred solution, the weight-average molecular weight of the fucoidan oligosaccharide is 4500-5500.
作为一种优选的方案，所述褐藻寡糖的重均分子量为4500～5500。As a preferred solution, the weight average molecular weight of the fucoidan oligosaccharide is 4500-5500.
作为一种优选的方案，所述褐藻寡糖的重均分子量为5000，可市售，例如山东洁晶集团。As a preferred solution, the weight-average molecular weight of the fucoidan oligosaccharide is 5000, which is commercially available, such as Shandong Jiejing Group.
作为一种优选的方案，所述卡拉胶寡糖购买自青岛隆川生物科技有限公司。As a preferred solution, the carrageenan oligosaccharides are purchased from Qingdao Longchuan Biotechnology Co., Ltd.
作为一种优选的方案，所述海藻活性肽为陕西夏州生物科技有限公司的海藻多肽。As a preferred solution, the seaweed active peptide is a seaweed polypeptide produced by Shaanxi Xiazhou Biotechnology Co., Ltd.
作为一种优选的方案，所述多酚类化合物为原花青素。As a preferred solution, the polyphenolic compound is proanthocyanidin.
作为一种优选的方案，所述原花青素为CAS号为41743-41-3，可市售，例如普思生物科技。As a preferred solution, the proanthocyanidin has a CAS number of 41743-41-3, which is commercially available, such as Pusi Biotechnology.
作为一种优选的方案，所述低乙酰化壳聚寡糖的粘度为脱乙酰程度为95％，粘度为200～400mPa.s，购买自罗恩试剂的R013967。As a preferred solution, the low acetylated chitosan oligosaccharide has a deacetylation degree of 95%, a viscosity of 200-400 mPa.s, and is purchased from R013967 of Ron Reagents.
作为一种优选的方案，所述多酚类化合物，低乙酰化壳聚寡糖的重量比为1：(1～1.1)。As a preferred solution, the weight ratio of the polyphenolic compound to the low acetylated chitosan oligosaccharide is 1: (1-1.1).
作为一种优选的方案，所述pH调节剂为柠檬酸，磷酸，磷酸钠和柠檬酸钠的一种或多种。As a preferred solution, the pH regulator is one or more of citric acid, phosphoric acid, sodium phosphate and sodium citrate.
作为一种优选的方案，所述pH调节剂为柠檬酸。As a preferred solution, the pH regulator is citric acid.
作为一种优选的方案，所述阳离子抗菌剂为聚六亚甲基双胍的盐酸盐。As a preferred solution, the cationic antibacterial agent is polyhexamethylene biguanide hydrochloride.
作为一种优选的方案，所述聚六亚甲基双胍的盐酸盐的重均分子量为2300～3100。As a preferred solution, the weight average molecular weight of the polyhexamethylene biguanide hydrochloride is 2300-3100.
作为一种优选的方案，所述聚六亚甲基双胍的盐酸盐的重均分子量为2500～2900，可市售，例如锦州九泰药业有限责任公司。As a preferred solution, the polyhexamethylene biguanide hydrochloride has a weight average molecular weight of 2500-2900 and is commercially available, for example, from Jinzhou Jiutai Pharmaceutical Co., Ltd.
作为一种优选的方案，所述辅料为所述辅料为皮肤粘合剂，润肤保湿剂的一种或多种。As a preferred solution, the auxiliary material is one or more of skin adhesives and emollients.
作为一种优选的方案，所述辅料为皮肤粘合剂，润肤保湿剂的混合物。As a preferred solution, the auxiliary material is a mixture of skin adhesive and moisturizing agent.
作为一种优选的方案，所述皮肤粘合剂，润肤保湿剂(5～8)：1。As a preferred solution, the skin adhesive, emollient and moisturizing agent (5-8): 1.
作为一种优选的方案，所述皮肤粘合剂为羧甲基纤维素钠。As a preferred solution, the skin adhesive is sodium carboxymethylcellulose.
作为一种优选的方案，所述润肤保湿剂为丙三醇。As a preferred solution, the emollient and moisturizing agent is glycerol.
本发明所述纯化水，是指纯水通过蒸馏法、离子交换法、反渗透法或其他适宜的方法制得的供药用的水，不含任何添加剂。The purified water in the present invention refers to the water for medicinal use obtained from pure water by distillation, ion exchange, reverse osmosis or other suitable methods, without any additives.
本发明的第二方面提供了一种强抗菌性的医用敷料的制备方法，主要包括以下步骤：The second aspect of the present invention provides a kind of preparation method of strong antibacterial medical dressing, mainly comprises the following steps:
(1)将皮肤粘合剂溶于纯化水中，制成溶液，用pH调节剂调节pH值，至5.0～7.0，放置3～4h，再用过滤膜过滤制得A组分，备用；(1) Dissolve the skin adhesive in purified water to make a solution, adjust the pH value to 5.0-7.0 with a pH regulator, let it stand for 3-4 hours, then filter it with a filter membrane to obtain component A, and set aside;
(2)将海洋活性生物提取物，多酚类化合物，低乙酰化壳聚寡糖，阳离子抗菌剂，辅料溶于A组分，灭菌，制得强抗菌性的医用敷料。(2) Marine active biological extracts, polyphenol compounds, low acetylated chitosan oligosaccharides, cationic antibacterial agents, and auxiliary materials are dissolved in component A and sterilized to prepare a strong antibacterial medical dressing.
本发明制备的强抗菌性的医用敷料颗吸附到敷料面层上。The strong antibacterial medical dressing particles prepared by the invention are adsorbed on the dressing surface layer.
作为一种优选的方案，所述敷料面层的材料为无纺布，生物纤维材料，果胶纤维布，棉布，蚕丝中的一种或多种。As a preferred solution, the material of the dressing surface layer is one or more of non-woven fabric, biological fiber material, pectin fiber cloth, cotton cloth and silk.
有益效果：Beneficial effect:
1.本发明通过限定重均分子量为4500～5500的褐藻寡糖易成膜，可在细菌的表面形成非常致密的高分子膜，一方面阻止了细菌从外界吸收营养，另一方面使细胞内的代谢产物无法排出，破坏新陈代谢，从而达到抑菌的效果。1. The present invention limits the easy film formation of fucoidan oligosaccharides with a weight average molecular weight of 4500 to 5500, and can form a very dense polymer film on the surface of bacteria, which prevents bacteria from absorbing nutrients from the outside on the one hand, and makes the inside of cells The metabolites cannot be excreted, destroying the metabolism, so as to achieve the antibacterial effect.
2.本发明中通过限定重量比为(2～4)：(2～4)：(4～6)的褐藻寡糖，卡拉胶寡糖，海藻活性肽，三者的协同作用，加强了抗氧化活性的能力，进而能够对受损皮肤起到修护作用，能够帮助受损肌肤的伤口愈合。2. in the present invention, be (2～4):(2～4):(4～6) fucoidan oligosaccharide, carrageenan oligosaccharide, seaweed active peptide by limiting weight ratio, the synergistic action of the three strengthens the anti-inflammatory effect. The ability of oxidation activity, and then can repair the damaged skin, and can help the wound healing of the damaged skin.
3.本发明通过羧甲基纤维素钠和卡拉胶寡糖协同作用能够使海藻纤维功能性敷料呈胶液状态，同时能够帮助受损肌肤伤口愈合，润肤保湿剂能够保持肌肤水分，进而保持伤口的湿润环境。3. The present invention can make the seaweed fiber functional dressing be in a glue state through the synergistic effect of sodium carboxymethylcellulose and carrageenan oligosaccharides, and can help damaged skin wounds heal at the same time, and the emollient and moisturizing agent can maintain skin moisture, thereby maintaining moist environment of the wound.
4.本发明通过限定重均分子量为2500～2900的聚六亚甲基双胍的盐酸盐与海洋活性生物提取物的协同作用，在有效地提高了体系的生物相容性的同时，也提高医用辅料抗菌效果，降低了伤口污染和感染的发生，减少了护理人员工作量，显著提高了临床经济效益。4. The present invention effectively improves the biocompatibility of the system and also improves The antibacterial effect of medical accessories reduces the occurrence of wound contamination and infection, reduces the workload of nursing staff, and significantly improves clinical economic benefits.
5.本发明通过用pH调节剂调节pH值，至5.0～7.0，放置3～4h，再用过滤膜过滤，提高了强抗菌性的医用敷料的稳定性，在保存过程中不变色，无异味产生。5. The present invention adjusts the pH value to 5.0 to 7.0 with a pH regulator, places it for 3 to 4 hours, and then filters it with a filter membrane to improve the stability of the strong antibacterial medical dressing. It does not change color and has no peculiar smell during storage. produce.
具体实施方式detailed description
实施例Example
实施例1Example 1
实施例1提供了一种强抗菌性的医用敷料，按重量份计，原料包含：海洋活性生物提取物10份，多酚类化合物3份，低乙酰化壳聚寡糖4份，pH调节剂0.6份，纯化水10份，阳离子抗菌剂0.03份，辅料4份。所述海洋活性生物提取物为褐藻寡糖，卡拉胶寡糖，海藻活性肽混合物。所述褐藻寡糖，卡拉胶寡糖，海藻活性肽中重量比为3：3：5。所述多酚类化合物为原花青素。Embodiment 1 provides a kind of strong antibacterial medical dressing, by weight, raw material comprises: 10 parts of marine active biological extracts, 3 parts of polyphenolic compounds, 4 parts of low acetylated chitosan oligosaccharides, pH regulator 0.6 parts, 10 parts of purified water, 0.03 parts of cationic antibacterial agent, 4 parts of auxiliary materials. The marine active biological extract is a mixture of fucoidan oligosaccharides, carrageenan oligosaccharides and seaweed active peptides. The weight ratio of the fucoidan oligosaccharide, carrageenan oligosaccharide and seaweed active peptide is 3:3:5. The polyphenolic compound is proanthocyanidin.
所述褐藻寡糖的重均分子量为5000，购买自山东洁晶集团。The weight-average molecular weight of the fucoidan oligosaccharide is 5000, purchased from Shandong Jiejing Group.
所述卡拉胶寡糖购买自青岛隆川生物科技有限公司。The carrageenan oligosaccharides were purchased from Qingdao Longchuan Biotechnology Co., Ltd.
所述海藻活性肽为陕西夏州生物科技有限公司的海藻多肽。The seaweed active peptide is a seaweed polypeptide produced by Shaanxi Xiazhou Biotechnology Co., Ltd.
所述原花青素为CAS号为41743-41-3，购买自普思生物科技。The proanthocyanidins have a CAS number of 41743-41-3 and were purchased from Pusi Biotechnology.
所述低乙酰化壳聚寡糖的粘度为脱乙酰程度为95％，粘度为300mPa.s，25℃购买自罗恩试剂的R013967。The low acetylated chitosan oligosaccharide has a deacetylation degree of 95%, a viscosity of 300 mPa.s, and was purchased from R013967 at 25° C. from Ron Reagents.
所述pH调节剂为柠檬酸(CAS号：77-92-9)。The pH regulator is citric acid (CAS number: 77-92-9).
所述阳离子抗菌剂为聚六亚甲基双胍的盐酸盐。所述聚六亚甲基双胍的盐酸盐的重均分子量为2700，购买自锦州九泰药业有限责任公司。The cationic antibacterial agent is polyhexamethylene biguanide hydrochloride. The polyhexamethylene biguanide hydrochloride has a weight average molecular weight of 2700 and was purchased from Jinzhou Jiutai Pharmaceutical Co., Ltd.
所述辅料为皮肤粘合剂，润肤保湿剂的混合物；所述皮肤粘合剂，润肤保湿剂6：1；所述皮肤粘合剂为羧甲基纤维素钠；所述润肤保湿剂为丙三醇。The auxiliary material is a skin adhesive, a mixture of emollient and moisturizing agents; the skin adhesive is a mixture of emollient and moisturizing agents; the skin adhesive is sodium carboxymethyl cellulose; the emollient and moisturizing The agent is glycerol.
本实施例所述纯化水，是指纯水通过蒸馏法、离子交换法、反渗透法或其他适宜的方法制得的供药用的水，不含任何添加剂。The purified water mentioned in this embodiment refers to the water for medicinal use obtained from pure water by distillation, ion exchange, reverse osmosis or other suitable methods, without any additives.
本实施例的第二方面提供了一种强抗菌性的医用敷料的制备方法，包括以下步骤：The second aspect of the present embodiment provides a method for preparing a strong antibacterial medical dressing, comprising the following steps:
(1)将皮肤粘合剂溶于纯化水中，制成溶液，用pH调节剂调节pH值，至6，放置3.5h，再用过滤膜过滤制得A组分，备用；(1) Dissolve the skin adhesive in purified water to make a solution, adjust the pH value to 6 with a pH regulator, let it stand for 3.5 hours, then filter it with a filter membrane to obtain component A, and set aside;
(2)将海洋活性生物提取物，多酚类化合物，壳聚糖，阳离子抗菌剂，辅料溶于A组分，灭菌，制得强抗菌性的医用敷料。(2) Marine active biological extracts, polyphenol compounds, chitosan, cationic antibacterial agents, and auxiliary materials are dissolved in component A and sterilized to prepare a strong antibacterial medical dressing.
实施例2Example 2
实施例2提供了一种强抗菌性的医用敷料，按重量份计，原料包含：海洋活性生物提取物18份，多酚类化合物6份，低乙酰化壳聚寡糖8份，pH调节剂1份，纯化水15份，阳离子抗菌剂0.06份，辅料7份。所述海洋活性生物提取物为褐藻寡糖，卡拉胶寡糖，海藻活性肽混合物。所述褐藻寡糖，卡拉胶寡糖，海藻活性肽中重量比为3：3：5。所述多酚类化合物为原花青素。Embodiment 2 provides a kind of strong antibacterial medical dressing, by weight, raw material comprises: 18 parts of marine active biological extracts, 6 parts of polyphenolic compounds, 8 parts of low acetylated chitosan oligosaccharides, pH regulator 1 part, 15 parts of purified water, 0.06 part of cationic antibacterial agent, 7 parts of auxiliary materials. The marine active biological extract is a mixture of fucoidan oligosaccharides, carrageenan oligosaccharides and seaweed active peptides. The weight ratio of the fucoidan oligosaccharide, carrageenan oligosaccharide and seaweed active peptide is 3:3:5. The polyphenolic compound is proanthocyanidin.
所述褐藻寡糖的重均分子量为5000，购买自山东洁晶集团。The weight-average molecular weight of the fucoidan oligosaccharide is 5000, purchased from Shandong Jiejing Group.
所述卡拉胶寡糖购买自青岛隆川生物科技有限公司。The carrageenan oligosaccharides were purchased from Qingdao Longchuan Biotechnology Co., Ltd.
所述海藻活性肽为陕西夏州生物科技有限公司的海藻多肽。The seaweed active peptide is a seaweed polypeptide produced by Shaanxi Xiazhou Biotechnology Co., Ltd.
所述原花青素为CAS号为41743-41-3，购买自普思生物科技。The proanthocyanidins have a CAS number of 41743-41-3 and were purchased from Pusi Biotechnology.
所述低乙酰化壳聚寡糖的粘度为脱乙酰程度为95％，粘度为300mPa.s，25℃购买自罗恩试剂的R013967。The low acetylated chitosan oligosaccharide has a deacetylation degree of 95%, a viscosity of 300 mPa.s, and was purchased from R013967 at 25° C. from Ron Reagents.
所述pH调节剂为柠檬酸(CAS号：77-92-9)。The pH regulator is citric acid (CAS number: 77-92-9).
所述阳离子抗菌剂为聚六亚甲基双胍的盐酸盐。所述聚六亚甲基双胍的盐酸盐的重均分子量为2700，购买自锦州九泰药业有限责任公司。The cationic antibacterial agent is polyhexamethylene biguanide hydrochloride. The polyhexamethylene biguanide hydrochloride has a weight average molecular weight of 2700 and was purchased from Jinzhou Jiutai Pharmaceutical Co., Ltd.
所述辅料为皮肤粘合剂，润肤保湿剂的混合物；所述皮肤粘合剂，润肤保湿剂6：1；所述皮肤粘合剂为羧甲基纤维素钠；所述润肤保湿剂为丙三醇。The auxiliary material is a skin adhesive, a mixture of emollient and moisturizing agents; the skin adhesive is a mixture of emollient and moisturizing agents; the skin adhesive is sodium carboxymethyl cellulose; the emollient and moisturizing The agent is glycerol.
本实施例所述纯化水，是指纯水通过蒸馏法、离子交换法、反渗透法或其他适宜的方法制得的供药用的水，不含任何添加剂。The purified water mentioned in this embodiment refers to the water for medicinal use obtained from pure water by distillation, ion exchange, reverse osmosis or other suitable methods, without any additives.
本实施例的第二方面提供了一种强抗菌性的医用敷料的制备方法，包括以下步骤：The second aspect of the present embodiment provides a method for preparing a strong antibacterial medical dressing, comprising the following steps:
(1)将皮肤粘合剂溶于纯化水中，制成溶液，用pH调节剂调节pH值，至6，放置3.5h，再用过滤膜过滤制得A组分，备用；(1) Dissolve the skin adhesive in purified water to make a solution, adjust the pH value to 6 with a pH regulator, let it stand for 3.5 hours, then filter it with a filter membrane to obtain component A, and set aside;
(2)将海洋活性生物提取物，多酚类化合物，壳聚糖，阳离子抗菌剂，辅料溶于A组分，灭菌，制得强抗菌性的医用敷料。(2) Marine active biological extracts, polyphenol compounds, chitosan, cationic antibacterial agents, and auxiliary materials are dissolved in component A and sterilized to prepare a strong antibacterial medical dressing.
实施例3Example 3
实施例3提供了一种强抗菌性的医用敷料，按重量份计，原料包含：海洋活性生物提取物4份，多酚类化合物2份，低乙酰化壳聚寡糖2份，pH调节剂0.5份，纯化水8份，阳离子抗菌剂0.01份，辅料1份。所述海洋活性生物提取物为褐藻寡糖，卡拉胶寡糖，海藻活性肽混合物。所述褐藻寡糖，卡拉胶寡糖，海藻活性肽中重量比为3：3：5。所述多酚类化合物为原花青素。Embodiment 3 provides a kind of strong antibacterial medical dressing, by weight, raw material comprises: 4 parts of marine active biological extracts, 2 parts of polyphenolic compounds, 2 parts of low acetylated chitosan oligosaccharides, pH adjuster 0.5 parts, 8 parts of purified water, 0.01 parts of cationic antibacterial agent, 1 part of excipients. The marine active biological extract is a mixture of fucoidan oligosaccharides, carrageenan oligosaccharides and seaweed active peptides. The weight ratio of the fucoidan oligosaccharide, carrageenan oligosaccharide and seaweed active peptide is 3:3:5. The polyphenolic compound is proanthocyanidin.
所述褐藻寡糖的重均分子量为5000，购买自山东洁晶集团。The weight-average molecular weight of the fucoidan oligosaccharide is 5000, purchased from Shandong Jiejing Group.
所述卡拉胶寡糖购买自青岛隆川生物科技有限公司。The carrageenan oligosaccharides were purchased from Qingdao Longchuan Biotechnology Co., Ltd.
所述海藻活性肽为陕西夏州生物科技有限公司的海藻多肽。The seaweed active peptide is a seaweed polypeptide produced by Shaanxi Xiazhou Biotechnology Co., Ltd.
所述原花青素为CAS号为41743-41-3，购买自普思生物科技。The proanthocyanidins have a CAS number of 41743-41-3 and were purchased from Pusi Biotechnology.
所述低乙酰化壳聚寡糖的粘度为脱乙酰程度为95％，粘度为300mPa.s，25℃购买自罗恩试剂的R013967。The low acetylated chitosan oligosaccharide has a deacetylation degree of 95%, a viscosity of 300 mPa.s, and was purchased from R013967 at 25° C. from Ron Reagents.
所述pH调节剂为柠檬酸(CAS号：77-92-9)。The pH regulator is citric acid (CAS number: 77-92-9).
所述阳离子抗菌剂为聚六亚甲基双胍的盐酸盐。所述聚六亚甲基双胍的盐酸盐的重均分子量为2700，购买自锦州九泰药业有限责任公司。The cationic antibacterial agent is polyhexamethylene biguanide hydrochloride. The polyhexamethylene biguanide hydrochloride has a weight average molecular weight of 2700 and was purchased from Jinzhou Jiutai Pharmaceutical Co., Ltd.
所述辅料为皮肤粘合剂，润肤保湿剂的混合物；所述皮肤粘合剂，润肤保湿剂6：1；所述皮肤粘合剂为羧甲基纤维素钠；所述润肤保湿剂为丙三醇。The auxiliary material is a skin adhesive, a mixture of emollient and moisturizing agents; the skin adhesive is a mixture of emollient and moisturizing agents; the skin adhesive is sodium carboxymethyl cellulose; the emollient and moisturizing The agent is glycerol.
本实施例所述纯化水，是指纯水通过蒸馏法、离子交换法、反渗透法或其他适宜的方法制得的供药用的水，不含任何添加剂。The purified water mentioned in this embodiment refers to the water for medicinal use obtained from pure water by distillation, ion exchange, reverse osmosis or other suitable methods, without any additives.
本实施例的第二方面提供了一种强抗菌性的医用敷料的制备方法，包括以下步骤：The second aspect of the present embodiment provides a method for preparing a strong antibacterial medical dressing, comprising the following steps:
(1)将皮肤粘合剂溶于纯化水中，制成溶液，用pH调节剂调节pH值，至6，放置3.5h，再用过滤膜过滤制得A组分，备用；(1) Dissolve the skin adhesive in purified water to make a solution, adjust the pH value to 6 with a pH regulator, let it stand for 3.5 hours, then filter it with a filter membrane to obtain component A, and set aside;
(2)将海洋活性生物提取物，多酚类化合物，壳聚糖，阳离子抗菌剂，辅料溶于A组分，灭菌，制得强抗菌性的医用敷料。(2) Marine active biological extracts, polyphenol compounds, chitosan, cationic antibacterial agents, and auxiliary materials are dissolved in component A and sterilized to prepare a strong antibacterial medical dressing.
性能测试：Performance Testing:
(1)稳定性：将实施例1～3中的样品，分别置于50℃下存放3个月进行稳定性考察，评价指标为外观(是否变色，气味)，结果如表1。(1) Stability: The samples in Examples 1 to 3 were stored at 50° C. for 3 months for stability investigation. The evaluation index was appearance (whether discoloration, smell), and the results are shown in Table 1.
性能测试结果：Performance test results:
表1是实施例1～3所制备强抗菌性的医用敷料的性能测试结果。Table 1 is the performance test results of the strong antibacterial medical dressings prepared in Examples 1-3.
表1Table 1
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202111657424.1ACN115607725A (en) | 2021-12-31 | 2021-12-31 | A kind of strong antibacterial medical dressing and preparation method thereof |
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202111657424.1ACN115607725A (en) | 2021-12-31 | 2021-12-31 | A kind of strong antibacterial medical dressing and preparation method thereof |
| Publication Number | Publication Date |
|---|---|
| CN115607725Atrue CN115607725A (en) | 2023-01-17 |
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202111657424.1APendingCN115607725A (en) | 2021-12-31 | 2021-12-31 | A kind of strong antibacterial medical dressing and preparation method thereof |
| Country | Link |
|---|---|
| CN (1) | CN115607725A (en) |
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN116688098A (en)* | 2023-06-28 | 2023-09-05 | 湖南银华棠医药科技有限公司 | HPV (human papilloma Virus) resisting biological protein functional dressing as well as preparation method and application thereof |
| CN117427201A (en)* | 2023-12-20 | 2024-01-23 | 辽宁帝东医药生物工程有限公司 | Antibacterial wound dressing capable of promoting healing |
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| CN104562438A (en)* | 2013-10-17 | 2015-04-29 | 中国科学院理化技术研究所 | Gelatin-based micro-nano fiber membrane material and preparation method and application thereof |
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| CN108367095A (en)* | 2015-10-08 | 2018-08-03 | 捷迈膝盖创造有限公司 | The curable calcium phosphate compositions being used together with porous structure and its application method |
| CN110049803A (en)* | 2017-01-09 | 2019-07-23 | 宝洁公司 | The method of barrier patch and improvement skin appearance with dissolvable film |
| CN113041389A (en)* | 2021-05-06 | 2021-06-29 | 南昌智产科技有限公司 | Medical dressing of antibiotic hydrophilic polyurethane foam |
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN104562438A (en)* | 2013-10-17 | 2015-04-29 | 中国科学院理化技术研究所 | Gelatin-based micro-nano fiber membrane material and preparation method and application thereof |
| CN108367095A (en)* | 2015-10-08 | 2018-08-03 | 捷迈膝盖创造有限公司 | The curable calcium phosphate compositions being used together with porous structure and its application method |
| CN110049803A (en)* | 2017-01-09 | 2019-07-23 | 宝洁公司 | The method of barrier patch and improvement skin appearance with dissolvable film |
| CN106822988A (en)* | 2017-02-08 | 2017-06-13 | 中英阿诺康（宁夏）生物科技有限公司 | Alginate fibre functional dressing and its application, alginate fibre functional dressing patch |
| CN113041389A (en)* | 2021-05-06 | 2021-06-29 | 南昌智产科技有限公司 | Medical dressing of antibiotic hydrophilic polyurethane foam |
| Title |
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| 奚延斐，周长忍: "《海洋生物医用材料大系》", 上海科学技术出版社, pages: 344 - 345* |
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| CN116688098A (en)* | 2023-06-28 | 2023-09-05 | 湖南银华棠医药科技有限公司 | HPV (human papilloma Virus) resisting biological protein functional dressing as well as preparation method and application thereof |
| CN117427201A (en)* | 2023-12-20 | 2024-01-23 | 辽宁帝东医药生物工程有限公司 | Antibacterial wound dressing capable of promoting healing |
| CN117427201B (en)* | 2023-12-20 | 2024-03-15 | 辽宁帝东医药生物工程有限公司 | Antibacterial wound dressing capable of promoting healing |
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