CN115500993A

Movatterモバイル変換

Info

Publication number: CN115500993A
Application number: CN202211066608.5A
Authority: CN
Inventors: 于春生; 董永华; 尹华清; 常永焕
Original assignee: Nanjing Rongsheng Medical Technology Co ltd
Current assignee: Nanjing Rongsheng Medical Technology Co ltd
Priority date: 2021-08-31
Filing date: 2022-08-31
Publication date: 2022-12-23

Abstract

The invention discloses a medical drug-loaded stent, which comprises an intracavity part, a neck part and a plurality of drug-loaded parts; wherein, the cavity inside and the neck inside adopt the integral type design, and the neck inside extends downwards from the cavity inside, and its length is equivalent with the length of cervical canal. The invention can simultaneously release medicine to the uterine cavity, the cervix and the vaginal orifice, and increase the medicine application area; the medicine can be loaded quickly, the operation time of a doctor is saved, and the time of the doctor exposing the radioactive substance is reduced; utilize the medicine carrying portion that distributes extensively, can be applicable to short-term and long-term demand of dosing simultaneously, put the medicine position moreover and can set up in a flexible way to realize accurate putting the medicine, reduce the dose.

Description

Translated fromChinese

一种医用载药支架A kind of medical drug-loaded stent

技术领域technical field

本发明涉及一种医用载药支架，尤其涉及一种适合宫腔颈内使用的医用载药支架，属于医疗器械技术领域。The invention relates to a medical drug-loaded stent, in particular to a medical drug-loaded stent suitable for use in the uterine cavity, belonging to the technical field of medical devices.

背景技术Background technique

宫腔内用药需要使用不同类型的载药支架。例如，授权公告号为 CN102860895B的中国发明专利中，披露了一种带缓释支架的子宫托。它采用的技术方案是通过在环形子宫托的内部安装有可缓释药物的支架，该支架与外界通过微孔膜隔离，该微孔膜上形成数个微孔，供微粒通过，能起到阴道给药作用。但是，其存在的问题是：这种微孔给药方式比较受限，仅限于0.1nm～10nm之间的药物，而且微孔直径太小容易堵塞，不利于内外物质的代谢流通；子宫托的植入方式，也会对患者造成一定程度的二次损伤。Intrauterine drug use requires the use of different types of drug-loaded stents. For example, in the Chinese invention patent whose authorized notification number is CN102860895B, a pessary with a slow-release stent is disclosed. The technical solution it adopts is to install a stent capable of sustained release of drugs inside the annular pessary. The stent is isolated from the outside world by a microporous membrane, and several micropores are formed on the microporous membrane for particles to pass through, which can play a role Vaginal administration effect. However, the existing problems are: this micropore drug delivery method is relatively limited, limited to drugs between 0.1nm and 10nm, and the diameter of the micropore is too small and easy to block, which is not conducive to the metabolism and circulation of internal and external substances; The implantation method will also cause a certain degree of secondary damage to the patient.

另一方面，在专利号为ZL 200620026919.9的中国实用新型中，披露了一种具有缓释控释剂型药物的子宫内给药装置，通过内部放置有药物的中空网状体，放置到子宫内进行缓释给药。该给药装置的体积较大，在植入过程中容易对患者造成损伤，而且其内部放置的药物容易由端口处掉落，本体自适应能力较差，无法对子宫内壁提供适宜的支撑力。On the other hand, in the Chinese utility model patent No. ZL 200620026919.9, an intrauterine drug delivery device with slow-release and controlled-release dosage forms is disclosed. Sustained release administration. The volume of the drug delivery device is large, and it is easy to cause damage to the patient during the implantation process, and the medicine placed inside it is easy to fall from the port.

综上所述，现有技术中还存在以下缺陷：In summary, there are also the following defects in the prior art:

(1)现有技术中的子宫支架不能完全支撑起子宫的形状，造成在宫角等处仍然容易发生粘连的现象；(1) the uterine stent in the prior art cannot fully support the shape of the uterus, causing adhesions to still easily occur at the uterine horns, etc.;

(2)现有技术中的子宫支架，不能充分的贴合宫腔，不利于药物释放到宫腔壁；(2) the uterine stent in the prior art cannot fully fit the uterine cavity, which is unfavorable for medicine to be released to the uterine cavity wall;

(3)现有技术没有子宫腔和子宫颈管内同时给药的设计，通常只是对子宫腔内用药。(3) The prior art does not have the design of drug administration in the uterine cavity and cervical canal at the same time, usually only the drug in the uterine cavity.

发明内容Contents of the invention

本发明所要解决的技术问题在于提供一种适合宫腔颈内使用的医用载药支架。The technical problem to be solved by the present invention is to provide a medical drug-loaded stent suitable for intracervical use.

为了实现上述目的，本发明采用以下的技术方案：In order to achieve the above object, the present invention adopts the following technical solutions:

一种医用载药支架，包括腔内部、颈内部以及多个载药部；其中，A medical drug-loaded stent, including the inside of the cavity, the inside of the neck, and a plurality of drug-loaded parts; wherein,

所述腔内部和颈内部采用一体式设计，The interior of the cavity and the interior of the neck adopt an integrated design,

所述颈内部从所述腔内部向下延伸，其长度与子宫颈管的长度相当。The neck interior extends downwardly from the lumen interior for a length comparable to the length of the cervical canal.

其中较优地，在所述腔内部上，设置有多个第二载药部，Wherein preferably, a plurality of second drug-loading parts are provided inside the cavity,

所述第二载药部包括囊体和设置在囊体的一端的开口部，用于容纳载药粒子，The second drug-loading part includes a capsule and an opening disposed at one end of the capsule for containing drug-loaded particles,

所述开口部的内径大于等于粒子的外径。The inner diameter of the opening is greater than or equal to the outer diameter of the particle.

其中较优地，所述囊体的一侧壁贯穿设置在编织丝上，并且在所述囊体与所述开口部相对的一端具有缩小部，所述缩小部的内径小于所述开口部的内径。Wherein preferably, one side wall of the capsule body is arranged through the braided wire, and there is a narrowing portion at the end of the capsule body opposite to the opening, and the inner diameter of the narrowing portion is smaller than that of the opening. the inside diameter of.

其中较优地，所述颈内部的外周均匀设置有多条第一载药部，Wherein preferably, a plurality of first drug-loading parts are uniformly arranged on the outer periphery of the neck,

所述第一载药部具有纵长的管状结构，用于容纳载药粒子。The first drug-loading part has a longitudinal tubular structure for containing drug-loaded particles.

其中较优地，所述第一载药部包括管体部和多个开口部，用于在载药时从所述开口部放入所述载药粒子。Wherein preferably, the first drug-loading part includes a tube body part and a plurality of openings for putting the drug-loaded particles from the openings when loading the drug.

其中较优地，所述开口部的开口方向和位置相同，并且是倾斜开口。Preferably, the openings of the openings have the same opening direction and position, and are inclined openings.

其中较优地，所述颈内部的外周均匀设置有多条所述第二载药部。Wherein preferably, a plurality of the second drug-loading portions are uniformly arranged on the inner periphery of the neck.

其中较优地，所述医用载药支架还包括阴道部，其伸出到宫颈口外的阴道内；所述阴道部上设置有用于取出所述医用载药支架的拉丝。Preferably, the medical drug-loaded stent also includes a vagina, which protrudes into the vagina outside the cervix; the vagina is provided with a drawing wire for taking out the medical drug-loaded stent.

其中较优地，所述载药部利用弹性的高分子材料制成，或者由镍钛的弹簧管制成。Wherein preferably, the drug-loading part is made of elastic polymer material, or made of nickel-titanium spring tube.

与现有技术相比较，本发明具有以下的技术效果：Compared with the prior art, the present invention has the following technical effects:

1.采用腔内部和颈内部的一体式设计，并且能同时对子宫腔和宫颈及阴道口放药，增加用药面积。1. It adopts the integrated design of the inside of the cavity and the inside of the neck, and can release medicine to the uterine cavity, cervix and vaginal opening at the same time, increasing the medication area.

2.利用开口囊状的载药部设计，可以快速载药，节约医生操作时间，并且减少医生显露在放射物的时间；而且还可以利用特定工装进行安全无辐射的载药。2. Using the design of the open capsule drug-loading part, it can quickly load the drug, save the doctor's operation time, and reduce the time of the doctor's exposure to radiation; moreover, it can also use specific tooling for safe and radiation-free drug loading.

3.利用分布广泛的载药部，同时可以适用于短期和长期给药需求，而且放药位置可灵活设置(可以选择对位于合适位置的部分载药部进行载药)，以实现精准放药，减少用药量。3. Using widely distributed drug-loading parts, it can be applied to both short-term and long-term drug delivery requirements, and the drug delivery position can be flexibly set (you can choose to load part of the drug-loading parts in a suitable position) to achieve precise drug delivery , reduce the dosage.

附图说明Description of drawings

图1A为本发明的第一实施例中，医用载药支架的侧面示意图；Fig. 1A is a schematic side view of a medical drug-loaded stent in the first embodiment of the present invention;

图1B为图1A的俯视示意图；FIG. 1B is a schematic top view of FIG. 1A;

图1C为图1A在体内放置的状态示意图；Fig. 1C is a schematic diagram of the state of Fig. 1A being placed in the body;

图2A为本发明的第二实施例中，医用载药支架的侧面示意图；Fig. 2A is a schematic side view of the medical drug-loaded stent in the second embodiment of the present invention;

图2B为图2A的俯视示意图；FIG. 2B is a schematic top view of FIG. 2A;

图2C为图2A在体内放置的状态示意图；Fig. 2C is a schematic diagram of the state of Fig. 2A being placed in the body;

图3A为本发明的第三实施例中，医用载药支架的侧面示意图；FIG. 3A is a schematic side view of a medical drug-loaded stent in a third embodiment of the present invention;

图3B为图3A的俯视图；Figure 3B is a top view of Figure 3A;

图3C为图3A在体内放置的状态示意图；Fig. 3C is a schematic diagram of the state of Fig. 3A being placed in the body;

图4A为本发明的第四实施例中，医用载药支架的侧面示意图；Fig. 4A is a schematic side view of a medical drug-loaded stent in a fourth embodiment of the present invention;

图4B为图4A的俯视示意图；FIG. 4B is a schematic top view of FIG. 4A;

图4C为图4A在体内放置的状态示意图；Fig. 4C is a schematic diagram of the state of Fig. 4A being placed in the body;

图5A为本发明的第五实施例中，医用载药支架的侧面示意图；Fig. 5A is a schematic side view of the medical drug-loaded stent in the fifth embodiment of the present invention;

图5B为图5A的俯视示意图；FIG. 5B is a schematic top view of FIG. 5A;

图5C为图5A在体内放置的状态示意图；Fig. 5C is a schematic diagram of the state of Fig. 5A being placed in the body;

图6A为本发明的第六实施例中，医用载药支架的侧面示意图；Fig. 6A is a schematic side view of the medical drug-loaded stent in the sixth embodiment of the present invention;

图6B为图6A中第一载药部60A的结构示意图；FIG. 6B is a schematic structural view of the first drug-loading part 60A in FIG. 6A;

图6C为图6A的俯视示意图；FIG. 6C is a schematic top view of FIG. 6A;

图6D为图6A中第二载药部60B的侧视局部剖面结构示意图；FIG. 6D is a side view partial cross-sectional structural schematic diagram of the second drug-loading part 60B in FIG. 6A;

图6E为图6A中第二载药部60B的俯视局部剖面结构示意图；FIG. 6E is a schematic top view partial cross-sectional structure diagram of the second drug-loading part 60B in FIG. 6A;

图7A为本发明的第七实施例中，医用载药支架的侧面示意图；Fig. 7A is a schematic side view of the medical drug-loaded stent in the seventh embodiment of the present invention;

图7B为图7A的俯视示意图；FIG. 7B is a schematic top view of FIG. 7A;

图8A为本发明的第八实施例中，医用载药支架的侧面示意图；Fig. 8A is a schematic side view of the medical drug-loaded stent in the eighth embodiment of the present invention;

图8B为图8A在体内放置的状态示意图；Fig. 8B is a schematic diagram of the state of Fig. 8A being placed in the body;

图9A为本发明的第九实施例中，医用载药支架的侧面示意图；Fig. 9A is a schematic side view of a medical drug-loaded stent in the ninth embodiment of the present invention;

图9B为图9A的俯视示意图；FIG. 9B is a schematic top view of FIG. 9A;

图10A为本发明的另一实施例中，医用载药支架的结构示意图；FIG. 10A is a schematic structural view of a medical drug-loaded stent in another embodiment of the present invention;

图10B为本发明的又一实施例中，医用载药支架的结构示意图；Fig. 10B is a schematic structural diagram of a medical drug-loaded stent in another embodiment of the present invention;

图10C为本发明的再一实施例中，医用载药支架的结构示意图；Fig. 10C is a schematic structural diagram of a medical drug-loaded stent in another embodiment of the present invention;

图11为本发明实施例中，植入管的结构示意图。Fig. 11 is a schematic structural diagram of an implant in an embodiment of the present invention.

具体实施方式detailed description

下面结合附图和具体实施例对本发明的技术内容进行详细具体的说明。The technical content of the present invention will be described in detail below in conjunction with the accompanying drawings and specific embodiments.

本发明实施例提供的医用载药支架至少包括腔内部、颈内部和载药部，其中腔内部用于贴合子宫腔内壁，颈内部用于贴合子宫颈道内壁，从而实现对子宫腔和子宫颈道内同时并且可靠送药的效果，特别适合在宫腔颈内使用。The medical drug-loaded stent provided by the embodiments of the present invention at least includes a cavity, a neck, and a drug-loading part, wherein the cavity is used to fit the inner wall of the uterine cavity, and the neck is used to fit the inner wall of the cervix, so as to realize the uterine cavity and uterine cavity. The effect of simultaneous and reliable drug delivery in the cervical canal is especially suitable for use in the cervix.

在本发明的一个实施例中，该医用载药支架的腔内部、颈内部是由高分子材料注塑成型，例如：pebax、硅胶、TPE、PEU(聚醚型聚氨酯) 及聚酯类(聚对苯二甲酸乙二酯)等。其中，编织类的医用载药支架的载药部，可以是高分子材料也可以是镍钛的弹簧管；管束类的医用载药支架的载药部则是由高分子材料制成，然后再安装到已制成的腔内部和/或颈内部。以下第一至第六实施例为编织类的医用载药支架；第七实施例是编织类和管束类相结合的医用载药支架；第八至第九实施例为管束类的医用载药支架。以下实施例中的形状、材料、尺寸等只是示意性表示，以方便理解，并不构成对本发明的限制。In one embodiment of the present invention, the inside of the cavity and the inside of the neck of the medical drug-loaded stent are injection molded by polymer materials, such as: pebax, silica gel, TPE, PEU (polyether polyurethane) and polyester (polyester) ethylene phthalate), etc. Among them, the drug-loading part of the braided medical drug-loaded stent can be a polymer material or a nickel-titanium spring tube; the drug-loaded part of the tube-like medical drug-loaded stent is made of a polymer material, and then Fits inside the cavity and/or inside the neck already made. The following first to sixth embodiments are braided medical drug-loaded stents; the seventh embodiment is a medical drug-loaded stent combining braided and tube bundles; the eighth to ninth embodiments are tube bundle medical drug-loaded stents . The shapes, materials, dimensions, etc. in the following embodiments are only schematic representations for easy understanding, and do not constitute limitations to the present invention.

<第一实施例><First embodiment>

如图1A～图1C所示，本发明实施例提供的医用载药支架100，包括腔内部11、颈内部12以及载药部10。医用载药支架100整体呈平板状，关于其中心线对称，由一根记忆合金金属丝预先弯曲成型，整体位于一个平面内(如图1B所示)。通过植入管放置在子宫腔和子宫颈内后，撤出植入管后，能自动形成预先成型的形状(图1C所示)。As shown in FIG. 1A to FIG. 1C , the medical drug-loadedstent 100 provided by the embodiment of the present invention includes acavity interior 11 , aneck interior 12 and a drug-loaded part 10 . The medical drug-loadedstent 100 is in the shape of a flat plate as a whole, symmetrical about its center line, and is pre-bent and shaped by a memory alloy wire, and the whole is located in a plane (as shown in FIG. 1B ). After being placed in the uterine cavity and cervix through the implant, the preformed shape can be formed automatically after withdrawal of the implant (shown in Figure 1C).

腔内部11包括两片网格状片材贴合在一起，形成平板状倒三角形结构，图中上方宽度大于下方的宽度，大致为三倍。如图1C所示，本发明实施例的医用载药支架100安装在体内后，该腔内部11的位于上方的两个角部110分别朝向子宫角方向；其位于下方的角朝向下方，即朝向子宫颈，作为连接部113。腔内部11是对称结构，在其中心线上的投影长度与子宫底到子宫颈管内口的长度大致相同。Thecavity interior 11 includes two grid-shaped sheets bonded together to form a flat plate-shaped inverted triangle structure, and the width at the top is greater than the width at the bottom in the figure, roughly three times. As shown in Figure 1C, after the medical drug-loadedstent 100 of the embodiment of the present invention is installed in the body, the twoupper corners 110 of thecavity 11 face the direction of the uterine horn respectively; The cervix serves as the connecting portion 113 . The inside of thecavity 11 is a symmetrical structure, and the projected length on its center line is approximately the same as the length from the fundus of the uterus to the internal opening of the cervical canal.

颈内部12呈长条状，从连接部113向下延伸，其长度与子宫颈管的长度相当。因此，如图1C所示，本发明实施例的医用载药支架100安装在体内后，颈内部12从子宫颈内口贯穿到子宫颈管，直到与子宫颈外口相平齐。The inner part of theneck 12 is elongated and extends downward from the connecting portion 113, and its length is equivalent to that of the cervical canal. Therefore, as shown in Figure 1C, after the medical drug-loadedstent 100 of the embodiment of the present invention is installed in the body, theinner neck 12 penetrates from the internal os of the cervix to the cervical canal until it is flush with the external os of the cervix.

因此，当安装在体内时，腔内部11被完全容纳在子宫腔内，其两侧紧贴子宫腔内壁的相对两侧(图中左右两侧)。颈内部12紧贴子宫颈管内壁相对两侧(图中左右两侧)，并且与子宫颈外口持平。药物颗粒安装在位于腔内部11和颈内部12的平面(图中的前后平面)上的载药部13 上，因此可与子宫腔或子宫颈接触。药物颗粒，可以是化疗药物，也可以是放射药物等各类需要持续放药的药物。Thus, when installed in the body, thecavity interior 11 is completely contained within the uterine cavity, with its two sides abutting the opposite sides of the inner wall of the uterine cavity (left and right in the figure). The inner part of theneck 12 is close to the opposite sides of the inner wall of the cervical canal (the left and right sides in the figure), and is flush with the outer os of the cervix. The drug particles are mounted on the drug-carryingportion 13 on the plane of thecavity interior 11 and the cervical interior 12 (anterior-posterior plane in the figure), and thus can come into contact with the uterine cavity or cervix. Drug particles can be chemotherapeutic drugs or radiopharmaceuticals and other drugs that require continuous drug delivery.

<第二实施例><Second Embodiment>

如图2A～图2C所示,本发明实施例提供的医用载药支架200，包括腔内部21、颈内部22、阴道部23，以及多个载药部20。医用载药支架 200关于其中心线对称，由一根记忆合金金属丝预先弯曲成型，整体位于一个平面内(如图2B所示)。通过植入管放置在子宫腔和子宫颈内后，撤出植入管后，能自动形成预先成型的形状(图2C所示)。As shown in FIGS. 2A to 2C , the medical drug-loadedstent 200 provided by the embodiment of the present invention includes a cavity interior 21, aneck interior 22, avaginal portion 23, and a plurality of drug-loadedportions 20. The medical drug-loadedstent 200 is symmetrical about its center line, and is pre-bent and formed by a memory alloy wire, and the whole is located in a plane (as shown in Figure 2B). After being placed in the uterine cavity and cervix through the implant tube, the preformed shape can be automatically formed after the implant tube is withdrawn (as shown in FIG. 2C ).

腔内部21包括位于上方两端的两个角部210、连接部211、突起部 212，以及位于两个角部210之间的弹性部213。角部210位于两侧，并且在安装到体内后其朝向子宫角方向(如图2C所示)。连接部211位于弹性部213下方，并且接近中心线的位置。在安装到体内后，两个连接部211均在子宫颈内口附近。突起部212包括两个，共中每一个从一个角部210向下延伸到连接部211。在安装到体内后，两个突起部212抵触到子宫腔两侧内壁，因此设置在腔内部21的载药部20可以对子宫腔内用药。The cavity interior 21 includes twocorners 210 at both ends above, a connectingpart 211, aprotrusion 212, and anelastic part 213 between the twocorners 210. Thehorns 210 are located on both sides, and after installation in the body they face in the direction of the uterine horns (as shown in Figure 2C). The connectingportion 211 is located below theelastic portion 213 and is close to the center line. After being installed in the body, the two connectingparts 211 are near the internal os of the cervix. The protrudingportion 212 includes two, each of which extends from onecorner portion 210 to theconnection portion 211 downward. After being installed in the body, the twoprotrusions 212 are in contact with the inner walls of both sides of the uterine cavity, so the drug-loading part 20 arranged inside the cavity 21 can administer medicine to the uterine cavity.

颈内部22从连接部311向下延伸，从子宫颈内口延伸到子宫颈外口，并连接阴道部23。因此，设置在颈内部22的载药部20位于子宫颈内，对子宫颈用药。The innercervical portion 22 extends downward from theconnection portion 311 , extends from the internal cervical os to the external cervical os, and connects thevaginal portion 23 . Therefore, the drug-carryingpart 20 provided in the inner part of theneck 22 is located in the cervix, and drugs are applied to the cervix.

阴道部23呈弧形，其一端与连接部311连接并向下延伸，另一端为向上延伸的自由端。结合图2A和图2C，在安装到体内后，阴道部23上方翻折后包围子宫颈外口。因此，阴道部23上设置的载药部20可以使得药物贴近子宫颈外口，对其用药。Vaginal portion 23 is arc-shaped, and one end thereof is connected with connectingportion 311 and extends downward, and the other end is a free end extending upward. With reference to Fig. 2A and Fig. 2C, after being installed in the body, the top of thevagina 23 is folded and surrounded by the external os of the cervix. Therefore, the drug-carryingportion 20 provided on thevaginal portion 23 can make the medicine close to the external os of the cervix, and administer medicine to it.

<第三实施例><Third embodiment>

如图3A～图3C所示，本发明实施例提供的医用载药支架300，包括腔内部31、颈内部32以及多个载药部30。医用载药支架300关于其中心线对称，由记忆合金金属丝缠绕而成，并且预先弯曲成型为大致椭圆锥体的形状。通过植入管放置在子宫腔和子宫颈内后，撤出植入管后，能自动形成预先成型的形状(图3C所示)。As shown in FIG. 3A to FIG. 3C , the medical drug-loadedstent 300 provided by the embodiment of the present invention includes acavity interior 31 , aneck interior 32 and a plurality of drug-loadedparts 30 . The medical drug-carryingstent 300 is symmetrical about its center line, is formed by winding memory alloy metal wires, and is pre-bent into a roughly elliptical cone shape. After being placed in the uterine cavity and cervix through the implant, the preformed shape can be automatically formed after the implant is withdrawn (as shown in FIG. 3C ).

腔内部31为上大下小的圆锥体形(椭圆椎形)。腔内部31包括两个角部310，连接部311以及收缩部314。角部310位于顶部两侧(即椭圆形的截面的端部)，并且在安装到体内后其朝向子宫角方向(如图3C所示)。连接部311位于角部310的下方并接近中心线的位置。在安装到体内后，两个连接部311均在子宫颈内口附近。收缩部314为椭圆椎形，连接角部310和连接部311，并且从角部310到连接部311的方向上其形状逐渐缩小，以与宫腔适形。设置在收缩部314的外周的载药部30上可以承载药物。The inside of thecavity 31 is in the shape of a cone (elliptical cone) with a large top and a small bottom. Thechamber interior 31 includes twocorners 310, a connectingportion 311 and a constriction 314. Thehorns 310 are located on both sides of the top (i.e. the ends of the elliptical cross-section), and they face in the direction of the uterine horns after installation in the body (as shown in Figure 3C). The connectingportion 311 is located below thecorner portion 310 and close to the centerline. After being installed in the body, the two connectingparts 311 are near the internal os of the cervix. The constriction part 314 is in the shape of an elliptical cone, connecting thecorner part 310 and theconnection part 311, and its shape is gradually reduced in the direction from thecorner part 310 to theconnection part 311, so as to conform to the shape of the uterine cavity. Drugs can be loaded on the drug-loading part 30 provided on the outer periphery of the constricted part 314.

颈内部32包括柱形本体320以及设置在本体320上的多个突出的环节321。本体320从连接部311向下延伸，并且其长度为从子宫颈内口到子宫颈外口的长度(参考图3C)。环节321沿着中心线的方向间隔设置在本体320上，形状为环状，并从本体320向外周方向突出，以增大与子宫颈管内壁的压力。因此，设置在颈内部32的，尤其是在环节321的，载药部30，被挤压到子宫颈内壁，从而提高载药部30上承载的药物浸入子宫颈管内壁的效果。Theneck interior 32 includes acylindrical body 320 and a plurality of protrudinglinks 321 provided on thebody 320 . Thebody 320 extends downward from the connectingportion 311, and has a length from the internal os of the cervix to the external os of the cervix (refer to FIG. 3C ). Thelink 321 is arranged on thebody 320 at intervals along the direction of the centerline, is annular in shape, and protrudes from thebody 320 to the peripheral direction to increase the pressure with the inner wall of the cervical canal. Therefore, the drug-carryingpart 30 arranged in the inner part of theneck 32, especially at thelink 321, is squeezed to the inner wall of the cervix, thereby improving the effect of the medicine carried on the drug-carryingpart 30 soaking into the inner wall of the cervical canal.

所以，本发明实施例是利用顶部313抵触子宫底、角部310部分伸入到子宫角，连接部311与子宫颈管内口的抵触，以及颈内部32与子宫颈管内壁挤压来可靠固定支架。Therefore, the embodiment of the present invention uses the top 313 to resist the fundus of the uterus, thecorner part 310 to partially extend into the uterine horn, theconnection part 311 to interfere with the inner opening of the cervical canal, and theinner neck 32 to press against the inner wall of the cervical canal to securely fix the bracket. .

<第四实施例><Fourth Embodiment>

本发明实施例与第三实施例的结构类似，在此重点描述与第三实施例不同之处，相同之处则省略或简单描述。The structure of the embodiment of the present invention is similar to that of the third embodiment, and the differences from the third embodiment are mainly described here, and the similarities are omitted or simply described.

如图4A～图4C所示的适合宫腔颈内使用的医用载药支架400，包括腔内部41、颈内部42、阴道部43以及多个载药部40。医用载药支架400 关于其中心线对称，由记忆合金金属丝缠绕而成，并且预先弯曲成型为大致椭圆锥体的形状。通过植入管放置在子宫腔和子宫颈内后，撤出植入管后，能自动形成预先成型的形状(图3C所示)。The medical drug-loadedstent 400 suitable for intracervical use as shown in FIGS. 4A to 4C includes acavity interior 41 , aneck interior 42 , avagina 43 and a plurality of drug-loadedsections 40 . The medical drug-carryingstent 400 is symmetrical about its center line, is formed by winding memory alloy wires, and is pre-bent into a roughly elliptical cone shape. After being placed in the uterine cavity and cervix through the implant, the preformed shape can be formed automatically after the implant is withdrawn (as shown in Figure 3C).

腔内部41为上大下小的椭圆锥体形(或圆椎形)。腔内部41包括连接部411、收缩部412以及顶部413。因为本发明实施例中，腔内部41 没有角部，所以是利用顶部413抵触子宫底以及连接部411与子宫颈管内口抵触来固定支架。The inside of thecavity 41 is in the shape of an elliptical cone (or cone) with a large top and a small bottom. Thecavity interior 41 includes aconnection part 411, aconstriction part 412 and atop part 413. Because in the embodiment of the present invention, the cavity inside 41 has no corners, so the support is fixed by using the top 413 to interfere with the fundus of the uterus and the connectingportion 411 to interfere with the internal opening of the cervical canal.

颈内部42包括柱形本体420以及设置在本体420上的多个突出的环节421。Theneck interior 42 includes acylindrical body 420 and a plurality of protrudinglinks 421 provided on thebody 420 .

在颈内部42的下方连接有阴道部43。阴道部43的形状为倒置的伞形。阴道部43的内部中心与颈内部42连接，阴道部43的外周从其内部中心向上延伸，形成碗形，用于设置在子宫颈管外口并且包围子宫颈管端部。阴道部43上设置的载药部40可以使得药物与子宫颈管外口的外壁接触，以对其进行用药。Avagina portion 43 is connected below theneck interior 42 . The shape of thevagina portion 43 is an inverted umbrella shape. The inner center of thevaginal part 43 is connected with the inner part of theneck 42, and the outer periphery of thevaginal part 43 extends upwards from the inner center thereof, forming a bowl shape for being arranged at the external opening of the cervical canal and surrounding the end of the cervical canal. The drug-loading part 40 provided on thevaginal part 43 can make the drug contact with the outer wall of the external opening of the cervix, so that it can be administered.

所以，本发明实施例是利用顶部413抵触子宫底、连接部411与子宫颈管内口的抵触，以及颈内部42与子宫颈管内壁挤压来可靠固定支架。Therefore, the embodiment of the present invention utilizes the resistance of the top 413 to the fundus of the uterus, the resistance of the connectingportion 411 to the inner opening of the cervical canal, and the compression of theinner neck 42 and the inner wall of the cervical canal to securely fix the stent.

<第五实施例><Fifth Embodiment>

如图5A～图5C所示的适合宫腔颈内使用的医用载药支架500，包括腔内部51、颈内部52以及多个载药部50。医用载药支架500关于其中心线对称，由记忆合金金属丝缠绕而成，并且预先弯曲成型为大致椭圆锥体的形状。通过植入管放置在子宫腔和子宫颈内后，撤出植入管后，能自动形成预先成型的形状(图5C所示)。The medical drug-loadedstent 500 suitable for intracervical use as shown in Fig. 5A to Fig. 5C includes acavity interior 51, aneck interior 52 and a plurality of drug-carryingparts 50. The medical drug-carryingstent 500 is symmetrical about its center line, is formed by winding memory alloy metal wires, and is pre-bent into a roughly elliptical cone shape. After being placed in the uterine cavity and cervix through the implant, the preformed shape can be formed automatically after the implant is withdrawn (as shown in FIG. 5C ).

腔内部51是大致球状或者椭球体状。腔内部51包括连接部511、突起部512，以及位于上方的顶部513。突起部512的截面围合成该椭圆形，以容纳在子宫腔内。安装在子宫腔内时，顶部513抵触在子宫腔内子宫底内壁，突起部512抵触在子宫腔四周内壁。利用设置在突起部512和顶部513的载药部50，可以对子宫腔内壁释放药物或进行放射治疗。Thecavity interior 51 is substantially spherical or ellipsoidal. Thecavity interior 51 includes aconnection portion 511, a protrudingportion 512, and atop portion 513 above. The section of theprotruding part 512 encloses the ellipse to be accommodated in the uterine cavity. When installed in the uterine cavity, the top 513 interferes with the inner wall of the uterine fundus in the uterine cavity, and theprotrusion 512 interferes with the inner wall around the uterine cavity. Utilizing the drug-carryingpart 50 provided on theprotruding part 512 and thetop part 513, drugs can be released to the inner wall of the uterine cavity or radiation therapy can be performed.

颈内部52从连接部511向下延伸，其长度与子宫颈管的长度相当，以使安装在体内的状态下，颈内部52下方连接的阴道部53可以从子宫颈外口伸出到阴道内。Theinner neck 52 extends downward from the connectingpart 511, and its length is equivalent to the length of the cervical canal, so that when installed in the body, thevaginal part 53 connected under theinner neck 52 can protrude from the external opening of the cervix into the vagina .

阴道部53呈半个圆环体状，其从颈内部52向上延伸以包覆子宫颈管外口的外壁。利用设置在阴道部53的载药部50，可以对子宫颈管外口的外壁释放药物或进行放射治疗。Thevaginal portion 53 is in the shape of a half torus, which extends upwards from the inner portion of theneck 52 to cover the outer wall of the external opening of the cervical canal. By using the drug-loading part 50 provided in thevagina 53, drugs can be released to the outer wall of the cervical canal or radiation therapy can be performed.

<第六实施例><Sixth Embodiment>

如图6A～图6E所示，本发明实施例提供的医用载药支架600，包括腔内部61、颈内部62以及多个载药部60。该医用载药支架600关于其中心线对称，由记忆合金金属丝缠绕而成，并且预先弯曲成型。通过植入管150放置在子宫腔和子宫颈内后，撤出植入管150后，利用材料的弹性能自动膨胀成预先成型的形状。As shown in FIGS. 6A to 6E , the medical drug-loadedstent 600 provided by the embodiment of the present invention includes acavity interior 61 , aneck interior 62 and a plurality of drug-loaded parts 60 . The medical drug-carryingstent 600 is symmetrical about its center line, is formed by winding memory alloy wires, and is pre-bent and formed. After being placed in the uterine cavity and cervix through theimplant tube 150, after theimplant tube 150 is withdrawn, it will automatically expand into a preformed shape by utilizing the elastic energy of the material.

该医用载药支架600还包括阴道部63，其伸出到宫颈口外的阴道内。在阴道部63还设置有用于取出医用载药支架600的拉丝64。拉丝64环绕阴道部63的端部一周(即，医用载药支架600的端部)，因此其受力收缩时会将医用载药支架600的端部整体收缩，其作用后文详述。The medical drug-loadedstent 600 also includes avagina part 63, which protrudes into the vagina outside the cervix. Adrawing wire 64 for taking out the medical drug-loadedstent 600 is also provided on thevagina 63 . Thedrawing wire 64 surrounds the end of the vagina 63 (i.e., the end of the medical drug-loaded stent 600), so when it shrinks under force, it will shrink the end of the medical drug-loadedstent 600 as a whole, and its function will be described in detail later.

腔内部61包括连接部611、突起部612及顶部613。顶部613在宫腔内可以抵接宫腔内壁。连接部611是圆柱形的网状结构(如图6A和6C 所示)，用于连接腔内部61和颈内部62。突起部612从连接部611向两侧延伸，呈弧形管状，以容纳在子宫腔内。安装在子宫腔内时，突起部 612抵触在子宫腔四周内壁。利用设置在连接部611和突起部612的多个载药部60，可以对子宫腔内壁释放药物或进行放射治疗。Thecavity interior 61 includes a connectingportion 611 , a protrudingportion 612 and a top 613 . The top 613 can abut the inner wall of the uterine cavity within the uterine cavity. Theconnection portion 611 is a cylindrical mesh structure (as shown in FIGS. 6A and 6C ), which is used to connect thecavity interior 61 and theneck interior 62 . The protrudingpart 612 extends to both sides from the connectingpart 611 and is in the shape of an arc tube to be accommodated in the uterine cavity. When installed in the uterine cavity, theprotrusion 612 is against the inner wall around the uterine cavity. Using the plurality of drug-carrying parts 60 provided on the connectingpart 611 and theprotruding part 612, drugs can be released to the inner wall of the uterine cavity or radiation therapy can be performed.

腔内部61和颈内部62是一体式结构，由高分子材料编织而成。颈内部62是圆柱形的网状结构(如图6A和6C所示)，其外周纵向设置有多条第一载药部60A。在本发明实施例中，颈内部62的外周均匀设置有 4条第一载药部60A。第一载药部60A的结构如图6B所示，是纵长的管状结构。第一载药部60A包括管体部603和多个开口部604。开口部604 的开口方向和位置相同，并且是倾斜开口(即，在管体部603上形成相对管体部603的轴线倾斜的开口)，以在载药时从开口部604放入粒子。管体部603的尺寸与粒子的尺寸相匹配，以满足既可以容纳粒子又对粒子有足够的摩擦力，使粒子在管体内部不会滑脱。较优地是，在管体部 603内部的位于相邻个开口部604之间的位置，设置突起结构或挡块结构，以确保粒子被放入后，在管体部603内不能滑动。The inside of thecavity 61 and the inside of theneck 62 are integral structures, which are braided by polymer materials. The inner part of theneck 62 is a cylindrical mesh structure (as shown in Figs. 6A and 6C ), and a plurality of first drug-loading parts 60A are longitudinally arranged on the outer periphery thereof. In the embodiment of the present invention, four first drug-loading portions 60A are uniformly arranged on the outer periphery of theinner neck 62 . The structure of the firstdrug loading portion 60A is a vertically long tubular structure as shown in Fig. 6B. The first drug-loading part 60A includes atube body part 603 and a plurality of openingparts 604 . The opening direction and position of theopening 604 are the same, and it is an inclined opening (that is, an opening inclined relative to the axis of thetube body 603 is formed on the tube body 603), so that particles are put into theopening 604 when loading the drug. The size of thetube body 603 matches the size of the particles, so as to accommodate the particles and have enough friction to the particles, so that the particles will not slip off inside the tube body. Preferably, a protruding structure or a stopper structure is provided at a position betweenadjacent openings 604 inside thetube body 603 to ensure that the particles cannot slide in thetube body 603 after being put in.

在腔内部61上，设置有多个第二载药部60B。每个载药部60B，如图6D～6E所示，包括U形的囊体602和设置在囊体602的一端的开口部 604。囊体602的一侧壁贯穿设置在编织丝601上，并且在其与开口部604 相对的一端具有缩小部605。开口部604的内径大于等于粒子的外径，缩小部605的内径小于粒子的外径，因此粒子被放入囊体602内之后，会被缩小部605阻挡而保留在囊体602内。较优地，囊体602的位于开口部604附近还设置有阻挡部603，其从囊体602的与编织丝601相连接的侧壁，向着开口部604延伸，以阻挡粒子从囊体602内滑落。On thecavity interior 61, a plurality of second drug-carryingportions 60B are provided. Each drug-loading portion 60B includes aU-shaped capsule 602 and anopening 604 provided at one end of thecapsule 602, as shown in Figs. 6D to 6E. One side wall of thecapsule body 602 is disposed through thebraided wire 601 , and has a narrowingportion 605 at its end opposite to theopening portion 604 . The inner diameter of theopening 604 is greater than or equal to the outer diameter of the particles, and the inner diameter of the narrowingportion 605 is smaller than the outer diameter of the particles, so after the particles are put into thecapsule 602, they will be blocked by the narrowingportion 605 and remain in thecapsule 602. Preferably, thecapsule body 602 is also provided with a blockingportion 603 near theopening portion 604, which extends from the side wall of thecapsule body 602 connected to thebraided wire 601 toward theopening portion 604, so as to prevent particles from entering thecapsule body 602. slide.

本发明各个实施例中的载药部均可以采用本发明实施例中的开口囊结构，但是也可以采用其他结构。例如，在颈内部62处也采用与第二载药部60B相同的结构。The drug-loading part in each embodiment of the present invention can adopt the open capsule structure in the embodiments of the present invention, but other structures can also be used. For example, the same structure as that of the second drug-loading portion 60B is also employed in theneck portion 62 .

<第七实施例><Seventh Embodiment>

如图7A～图7B所示，本发明实施例提供的医用载药支架700，包括腔内部71、颈内部72以及多个载药部70。医用载药支架700关于其中心线对称，由记忆合金金属丝缠绕而成，并且预先弯曲成型。通过植入管150放置在子宫腔和子宫颈内后，撤出植入管150后，能自动形成预先成型的形状。As shown in FIGS. 7A-7B , the medical drug-loadedstent 700 provided by the embodiment of the present invention includes acavity interior 71 , aneck interior 72 and a plurality of drug-loaded parts 70 . The medical drug-loadedstent 700 is symmetrical about its center line, is formed by winding memory alloy wires, and is pre-bent to form. After being placed in the uterine cavity and cervix through theimplant tube 150, after withdrawing theimplant tube 150, it can automatically form a preformed shape.

腔内部71包括连接部711、突起部712及顶部713。顶部713在宫腔内可以抵接宫腔内壁。连接部711是圆柱形的网状结构(如图7A和7B 所示)，用于连接腔内部71和颈内部72。突起部712从连接部711向两侧延伸，呈弧形管状，以容纳在子宫腔内。利用设置在颈内部72和突起部712的多个载药部70，可以对子宫腔内壁释放药物或进行放射治疗。Thecavity interior 71 includes a connectingportion 711 , a protrudingportion 712 and a top 713 . The top 713 can abut the inner wall of the uterine cavity in the uterine cavity. Theconnection portion 711 is a cylindrical mesh structure (as shown in FIGS. 7A and 7B ) for connecting thecavity interior 71 and theneck interior 72 . The protrudingpart 712 extends to both sides from the connectingpart 711 and is in the shape of an arc tube to be accommodated in the uterine cavity. With the plurality of drug-carrying parts 70 provided in the inner part of theneck 72 and theprotruding part 712, drugs can be released to the inner wall of the uterine cavity or radiation therapy can be performed.

颈内部72的外周均匀设置有4条第一载药部70A。第一载药部70A 的结构如图6B所示。突起部712的管腔具有与第一载药部70A相类似的结构，可以参考图6B所示的第一载药部60A的结构。Four first drug-loading portions 70A are uniformly arranged on the outer periphery of theneck 72 . The structure of the firstdrug loading portion 70A is shown in FIG. 6B. The lumen of theprotruding part 712 has a structure similar to that of the first drug-loading part 70A, and the structure of the first drug-loading part 60A shown in Fig. 6B can be referred to.

<第八实施例><Eighth embodiment>

如图8A-8B所示，宫腔颈内使用的医用载药支架800，包括腔内部 81、颈内部82、以及多个载药部80。医用载药支架800关于其中心线对称，由记忆合金金属丝缠绕而成，并且预先弯曲成型。通过植入管150 放置在子宫腔和子宫颈内后，撤出植入管150后，能自动形成预先成型的形状。As shown in Figures 8A-8B, the medical drug-loadedstent 800 used in the uterine cavity includes acavity interior 81, aneck interior 82, and a plurality of drug-loadedparts 80. The medical drug-carryingstent 800 is symmetrical about its center line, is formed by winding memory alloy metal wires, and is pre-bent to shape. After being placed in the uterine cavity and cervix through theimplant tube 150, the preformed shape can be formed automatically after theimplant tube 150 is withdrawn.

腔内部81包括连接部811和突起部812。连接部811是圆柱形，以沿着阴道，被送入并固定在子宫腔内。突起部812从连接部811向两侧延伸，呈弧形管状，以容纳在子宫腔内。安装在子宫腔内时，突起部812 抵触在子宫腔四周内壁。利用设置在连接部811和突起部812的多个载药部80，可以对子宫腔内壁释放药物或进行放射治疗。Thecavity interior 81 includes aconnection part 811 and aprotrusion part 812 . Theconnection part 811 is cylindrical, so as to be sent into and fixed in the uterine cavity along the vagina. The protrudingpart 812 extends to both sides from the connectingpart 811 and is in the shape of an arc tube to be accommodated in the uterine cavity. When installed in the uterine cavity, the protrudingpart 812 is against the inner wall around the uterine cavity. Using the plurality of drug-carryingparts 80 provided on the connectingpart 811 and theprotruding part 812, drugs can be released to the inner wall of the uterine cavity or radiation therapy can be performed.

颈内部82从连接部811向下延伸，其长度与子宫颈管的长度相当，以使安装在体内的状态下，颈内部82下方连接的阴道部83可以从子宫颈外口伸出到阴道内。The inner part of theneck 82 extends downward from the connectingpart 811, and its length is equivalent to the length of the cervical canal, so that when installed in the body, thevaginal part 83 connected under the inner part of theneck 82 can protrude from the external opening of the cervix into the vagina .

阴道部83呈弧形管状，其从颈内部82的远离腔内部81的一端开始，朝向腔内部81的方向延伸，以包覆子宫颈管外口的外壁。而且，阴道部 83和突起部812的形状相同，平行设置，在俯视角度上的投影重叠(可以参考图9B)。利用设置在阴道部83的载药部80，可以对子宫颈管外口的外壁释放药物或进行放射治疗。Thevagina 83 is in the shape of an arc tube, which starts from the end of theneck 82 away from thecavity 81 and extends toward thecavity 81 to cover the outer wall of the cervical canal. Moreover, the shape of thevagina portion 83 and the protrudingportion 812 are the same, they are arranged in parallel, and the projections on the plan view angle overlap (refer to FIG. 9B). Utilizing the drug-carryingpart 80 provided in thevaginal part 83, drugs can be released to the outer wall of the external orifice of the cervix or radiotherapy can be performed.

载药部80包括位于颈内部82的多个第一载药部80A，以及位于阴道部83和突起部812的多个第二载药部80B。第一载药部80A是长条状的管材，与图6B所示的第六实施例中的第一载药部60A相同的结构，在此不赘述。第二载药部80B位于突起部812的管腔内或者阴道部83的管腔内，具有与图6B所示的类似的开口囊状结构，只是管体部为弧形管状而不是图6B所示的直线状。The drug-loadedpart 80 includes a plurality of first drug-loadedparts 80A located in theneck interior 82 , and a plurality of second drug-loadedparts 80B located in thevaginal part 83 and theprotrusion part 812 . The first drug-carryingpart 80A is an elongated tube, and has the same structure as the first drug-carryingpart 60A in the sixth embodiment shown in FIG. 6B , so it will not be repeated here. The second drug-loading part 80B is located in the lumen of theprotruding part 812 or the lumen of thevaginal part 83, and has an open capsule structure similar to that shown in FIG. straight line shown.

<第九实施例><Ninth Embodiment>

如图9A～图9B所示，本发明实施例提供的医用载药支架900，包括腔内部91、颈内部92以及多个载药部90。医用载药支架900关于其中心线对称，由记忆合金金属丝缠绕而成，并且预先弯曲成型。通过植入管150放置在子宫腔和子宫颈内后，撤出植入管150后，能自动形成预先成型的形状。As shown in FIGS. 9A to 9B , the medical drug-loadedstent 900 provided by the embodiment of the present invention includes acavity interior 91 , aneck interior 92 and a plurality of drug-loadedparts 90 . The medical drug-carryingstent 900 is symmetrical about its center line, is formed by winding memory alloy metal wires, and is pre-bent to shape. After being placed in the uterine cavity and cervix through theimplant tube 150, after withdrawing theimplant tube 150, it can automatically form a preformed shape.

腔内部91包括连接部911、突起部912和顶部913。顶部913在宫腔内可以抵接宫腔内壁。连接部911用于连接腔内部91和颈内部92。突起部912从连接部911向两侧延伸，呈弧形条状，以容纳在子宫腔内。利用设置在颈内部92和突起部912的多个载药部90，可以对子宫腔内壁释放药物或进行放射治疗。Thecavity interior 91 includes aconnection part 911 , aprotrusion part 912 and atop part 913 . The top 913 can abut the inner wall of the uterine cavity within the uterine cavity. The connectingportion 911 is used to connect thecavity interior 91 and theneck interior 92 . The protrudingpart 912 extends from the connectingpart 911 to both sides, and is in the shape of an arc strip, so as to be accommodated in the uterine cavity. Using the plurality of drug-carryingparts 90 provided on the inside of theneck 92 and theprotruding part 912, drugs can be released to the inner wall of the uterine cavity or radiation therapy can be performed.

在本发明实施例中，只有腔内部91上设置有载药部90，颈内部72 没有载药部。载药部90结构如图6D～6E所示，在此不赘述。In the embodiment of the present invention, only thecavity interior 91 is provided with the drug-loadedportion 90 , and theneck interior 72 has no drug-loaded portion. The structure of the drug-loading part 90 is shown in FIGS. 6D to 6E , and will not be described in detail here.

<第十实施例><Tenth Embodiment>

本发明实施例提供的医用载药支架，包括腔内部101A、101B、101C，颈内部102A、102B、102C，以及多个载药部。比第九实施例增加了阴道部103A、103B、103C，其余结构类似，在此不赘述。阴道部103A、103B、 103C从颈内部102A、102B、102C向远离腔内部101A、101B、101C的方向向四周扩张。The medical drug-loaded stent provided by the embodiment of the present invention includescavity interiors 101A, 101B, and 101C,neck interiors 102A, 102B, and 102C, and multiple drug-loading parts. Compared with the ninth embodiment, thevagina parts 103A, 103B, and 103C are added, and the rest of the structures are similar, and will not be repeated here. Thevaginal portion 103A, 103B, 103C expands in a direction away from the inner portion of thecavity 101A, 101B, 101C from the inner portion of theneck 102A, 102B, 102C.

下面结合图11介绍本发明实施例中的植入管150。该植入管150包括手柄151、伸缩管152、套管153以及头部154。伸缩管152的一端与手柄151连接，另一端与头部154连接，并且可滑动地容纳在套管153 内部。Theimplant 150 in the embodiment of the present invention will be described below with reference to FIG. 11 . Theimplant 150 includes ahandle 151, atelescoping tube 152, asleeve 153 and ahead 154. Thetelescoping tube 152 is connected to thehandle 151 at one end and to thehead 154 at the other end, and is slidably accommodated inside thesleeve 153.

手柄151用于操作伸缩管152，使其沿着套管153内部双向移动。同时，操作手柄151还可以用于控制头部154的张开或闭合，以夹持着拉丝(例如图6A中的拉丝64或图7A中所示的拉丝74)。Thehandle 151 is used to operate thetelescopic tube 152 to move bidirectionally along the inside of thecasing 153 . At the same time, the operating handle 151 can also be used to control the opening or closing of thehead 154 to hold the wire (such as thewire 64 in FIG. 6A or thewire 74 shown in FIG. 7A ).

在植入时，将前述各实施例中的医用载药支架收缩并容纳在套管153 内。在超声下让套管153放置到宫腔颈内预期的位置，用定位游标固定植入管150深入宫腔的深度，然后保持套管153不动，通过操作手柄，推动伸缩管152使其对医用载药支架的端部施加推力。同时套管153相对后退，使医用载药支架从套管153中脱落出来并留置在宫腔内，在自膨胀力作用下自动扩张成预设的形状。During implantation, the medical drug-loaded stents in the foregoing embodiments are shrunk and accommodated in thesleeve 153 . Place thecannula 153 at the expected position in the cervix under ultrasound, fix the depth of the implantedtube 150 into the uterine cavity with a positioning cursor, then keep thecannula 153 still, and push thetelescopic tube 152 to make it aligned by operating the handle. The end of the medical drug-loaded stent exerts a pushing force. At the same time, thesleeve 153 retreats relatively, so that the medical drug-loaded stent falls out of thesleeve 153 and stays in the uterine cavity, and automatically expands into a preset shape under the action of the self-expanding force.

在取出时，将植入管150送到阴道内或宫颈内，使套管153位于预设的位置。然后，操作手柄151，使头部154张开并夹住拉丝；再操作手柄151使头部154闭合。再操作手柄，使伸缩管152沿着套管153相对向远离宫腔的方向退出预设距离。该预设距离正好使得医用载药支架能被容纳在套管153内。利用头部154拉动拉丝，使医用载药支架端部收缩，以被收缩在套管153内。在医用载药支架被容纳到套管153内之后，将整体个植入管150取出，从而将医用载药支架取出宫腔。When taking out, theimplant tube 150 is delivered to the vagina or cervix so that thesleeve 153 is positioned at the preset position. Then, operate thehandle 151 to make thehead 154 open and clamp the drawing wire; operate thehandle 151 again to make thehead 154 close. Operate the handle again to make thetelescopic tube 152 withdraw from the preset distance relative to the direction away from the uterine cavity along thesleeve tube 153. This preset distance is just so that the medical drug-loaded stent can be accommodated in thesleeve 153. Utilize thehead 154 to pull the drawing wire, so that the end of the medical drug-loaded stent is shrunk, so as to be shrunk in thesleeve pipe 153. After the medical drug-loaded stent is accommodated in thecasing 153, thewhole implant tube 150 is taken out, so that the medical drug-loaded stent is taken out of the uterine cavity.

因此，本发明实施例提供的医用载药支架，可以同时对宫腔和宫颈及阴道口定点给药，长期/短期缓释药剂的装置，实现既能具有长期/短期缓释给药功能，同时使用简便，对患者损伤小，具有以下的技术效果：Therefore, the medical drug-loaded stent provided by the embodiment of the present invention can simultaneously administer fixed-point medication to the uterine cavity, cervix, and vaginal opening, and is a long-term/short-term sustained-release drug device, which can realize both long-term/short-term sustained-release drug delivery functions, and at the same time It is easy to use, has little damage to the patient, and has the following technical effects:

上面对本发明所提供的医用载药支架进行了详细的说明。对本领域的一般技术人员而言，在不背离本发明实质内容的前提下对它所做的任何显而易见的改动，都将构成对本发明专利权的侵犯，将承担相应的法律责任。The medical drug-loaded stent provided by the present invention has been described in detail above. For those of ordinary skill in the art, any obvious changes made to it without departing from the essence of the present invention will constitute an infringement of the patent right of the present invention and will bear corresponding legal responsibilities.