CN115244403A - Sample analysis device and method - Google Patents

Abstract

Translated fromChinese

一种样本分析装置及方法，提供第一类型测定位及第二类型测定位；将第一容器运送至第一类型测定位和/或第二类型测定位；对第一类型测定位照射第一强度的光，和/或对第二类型测定位照射第二强度的光；所述第一强度小于第二强度；获取第一强度的光和/或第二强度的光对应的光学检测信息；根据所述第一强度的光和/或所述第二强度的光对应的光学检测信息，对所述样本进行检测结果分析。

A sample analysis device and method, providing a first-type measurement site and a second-type measurement site; transporting a first container to the first-type measurement site and/or the second-type measurement site; irradiating the first-type measurement site with a first Intensity of light, and/or irradiating light of second intensity to the second type of measuring position; the first intensity is less than the second intensity; obtaining optical detection information corresponding to the light of the first intensity and/or the light of the second intensity; According to the optical detection information corresponding to the light of the first intensity and/or the light of the second intensity, a detection result is analyzed on the sample.

Description

Translated fromChinese

PCT国内申请，说明书已公开。PCT domestic application, the description has been published.

Claims (23)

1. A sample analysis apparatus, comprising:

   the optical detection component comprises a first type detection position and a first detector corresponding to the first type detection position, a second type detection position and a second detector corresponding to the second type detection position;

   the illumination component is used for providing light with first intensity to a first container which is positioned at the first type measuring position and is filled with a measuring sample, and providing light with second intensity to a first container which is positioned at the second type measuring position and is filled with the measuring sample; the measuring sample is prepared from a sample and a reagent; the first intensity is less than the second intensity;

   a transport component for transporting the first container to the first or second type of test location;

   and the control component is used for controlling the conveying component to convey the first container filled with the determination sample to the first type determination position or the second type determination position according to the interferent detection information of the sample for optical detection.
2. The sample analysis device of claim 1, wherein the optical detection component is configured to receive an output optical signal from the first container in the first type of assay site or the second type of assay site after illumination by the illumination component and convert the output optical signal to a corresponding electrical signal; the output optical signal comprises at least one of transmitted light, reflected light, or scattered light;

   the sample analysis device further includes an analysis section for analyzing the electric signal to perform analysis of a sample test item.
3. The sample analyzing apparatus according to claim 1 or 2, further comprising an interferent detection means for performing interferent detection on the sample to obtain the interferent detection information, the interferent detection information being indicative of whether an interferent content of the sample exceeds a threshold, the control means being adapted to control the transport means to transport the first container to the first type of location when the interferent content of the sample does not exceed the threshold; or when the interferent content of the sample exceeds a threshold, controlling the transport component to transport the first container to the second type of measurement location.
4. The sample analysis device of claim 3, wherein the interferent detection means comprises an interferent detection bit and a third detector located to one side of the interferent detection bit; the illumination component is used for illuminating a second container which is positioned at an interfering object detection position and at least contains a sample, and the interfering object detection component is used for receiving an output optical signal of the second container after the second container is illuminated by the illumination component so as to obtain interfering object detection information of the sample.
5. The sample analyzer according to claim 4, further comprising a dispensing unit, wherein the control unit controls the dispensing unit to dispense a part of the sample and a diluent into the second container, and controls the dispensing unit to dispense another part of the sample and a detection reagent into the first container, thereby preparing the measurement sample.
6. The sample analysis device of claim 4 or 5, wherein the first container is a reaction cuvette and the second container is a cuvette.
7. The sample analysis device of any one of claims 4-6, wherein the illumination means comprises a first light source and a one-to-many fiber optic beam providing light of the first intensity to the first type of detection site and the interferent detection site, respectively.
8. The sample analyzing apparatus according to claim 1 or 7, wherein the illumination means further comprises a second light source for providing light of the second intensity to illuminate the first container containing the assay sample at the second type of assay site.
9. The sample analyzing apparatus of claim 8, wherein the first light source is a multi-wavelength light source for providing light of at least a first wavelength, a second wavelength, and a third wavelength; preferably, the first wavelength is in the range of 340nm to 420nm, the second wavelength is in the range of 520nm to 590nm, and the third wavelength is in the range of 660nm to 800nm.
10. The sample analysis device of claim 9, wherein the second light source is a single wavelength light source for providing light at a fourth wavelength that is not less than any of the first, second, or third wavelengths.
11. The sample analyzer of claim 1 wherein the illumination assembly illuminates a first container containing an assay sample at the first type of assay location with light of a first intensity, and the first detector is configured to receive an output optical signal of the first container illuminated by the illumination assembly to obtain the analyte detection information of the sample.
12. The sample analysis device of any of claims 1-11, wherein the sample is a blood sample and the interferent comprises at least one of hemoglobin, bilirubin, and chyle.
13. The sample analysis device of any of claims 1-12, wherein the interferent detection information comprises at least one of absorbance of light, or transmission of light, by the sample at different wavelengths.
14. A sample analysis apparatus, comprising:

    the optical detection component comprises a first type of measurement and positioning and a first detector corresponding to the first type of measurement and positioning, a second type of measurement and positioning and a second detector corresponding to the second type of measurement and positioning;

    a transport member for transporting a container containing an assay sample to at least one of the first type of assay site or the second type of assay site for optical detection; the determination sample is prepared from a sample and a reagent;

    the illumination component is used for providing light with first intensity to a first container which is positioned at the first type measuring position and is filled with a measuring sample, and providing light with second intensity to a first container which is positioned at the second type measuring position and is filled with the measuring sample; the first intensity is less than the second intensity; the first detector is used for acquiring first optical detection information corresponding to the light with the first intensity, and the second detector is used for acquiring second optical detection information corresponding to the light with the second intensity;

    and the analysis component is used for analyzing the detection result of the sample according to at least one of the first optical detection information or the second optical detection information.
15. The sample analyzing apparatus according to claim 14, further comprising a sample interference detecting means for performing interference detection on the sample to obtain interference detection information of the sample, the interference detection information indicating whether an interference content of the sample exceeds a threshold value, and a control means for controlling the transport means to transport the first container to the first type of measurement location when the interference content of the sample does not exceed the threshold value; or controlling the transport component to transport the first container to the second type of measurement location when the interferent content of the sample exceeds a threshold.
16. The sample analyzer of claim 14 wherein the illumination assembly illuminates a first container containing the assay sample at the first type of assay site with light of a first intensity, the first detector further receiving an output optical signal from the first container illuminated by the illumination assembly to obtain a luminous flux of the assay sample; the transport means is for transporting the first container to the second type of assay location when the luminous flux of the assay sample does not exceed a threshold value.
17. A method of sample analysis, comprising:

    providing a first type of measurement and positioning and a second type of measurement and positioning;

    dispensing a sample and a reagent into a first container to prepare an assay sample;

    transporting the first container to a first type of test location and/or a second type of test location;

    illuminating a first intensity of light to the first type of measurement location and/or illuminating a second intensity of light to the second type of measurement location; the first intensity is less than the second intensity;

    acquiring optical detection information corresponding to the light with the first intensity and/or the light with the second intensity;

    and analyzing the detection result of the sample according to optical detection information corresponding to the light with the first intensity and/or the light with the second intensity.
18. The method of claim 17, further comprising performing interferent detection on the sample to obtain interferent detection information for the sample prior to transporting the first container to the first type of test location and/or the second type of test location, the interferent detection information indicating whether an interferent level of the sample exceeds a threshold; said transporting the first container to the first type of test location and/or the second type of test location comprises:

    transporting the first container to the first type of location if the interferent content of the sample does not exceed a threshold; or

    Transporting the first container to the second type of measurement location if the interferent content of the sample exceeds a threshold.
19. The method of claim 18, wherein performing interferent detection on the sample to obtain interferent detection information for the sample comprises:

    dispensing a portion of the sample and a diluent into a second container;

    illuminating the second container with light of a first intensity;

    receiving an output optical signal after illuminating the second receptacle;

    converting the optical signal into an electrical signal;

    and analyzing the electric signal to obtain the detection information of the interferent of the sample.
20. The method of claim 17, further comprising obtaining interferent detection information for the assay sample at the first type of assay location after transporting the first container to the first type of assay location, the interferent detection information indicating whether an interferent content of the sample exceeds a threshold; said transporting the first container to the first type of test location and/or the second type of test location comprises:

    transporting the first container from the first type of measurement location to the second type of measurement location if the interferent content of the sample exceeds a threshold.
21. The method of claim 17, wherein said transporting the first container to the first type of test location and/or the second type of test location comprises:

    transporting the first container to the first type of assay location for optical assay; and

    transporting the first container to the second type of assay location for optical assay.
22. The method of claim 21, wherein analyzing the detection of the sample based on the optical detection information measured at the first type of assay site and/or the second type of assay site comprises: selecting optical detection information measured at the first type measurement position or the second type measurement position according to the detection information of the interferent of the sample; and analyzing the detection result of the sample according to the selected optical detection information.
23. The method of claim 22, further comprising obtaining interferent detection information for the sample, the interferent detection information indicating whether an interferent content of the sample exceeds a threshold; the selecting optical detection information measured at the first type of assay location or the second type of assay location based on the interferent detection information for the sample comprises:

    selecting optical detection information measured by the first type of measurement location if the interferent content of the sample does not exceed a threshold;

    selecting optical detection information measured by the second type of measurement location if the interferent content of the sample exceeds a threshold.

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