技术领域Technical field
本发明创造属于超声治疗技术领域，尤其是涉及一种可用于浅皮下透皮给药的小型换能器及其制作方法。The invention belongs to the technical field of ultrasonic therapy, and in particular relates to a small transducer that can be used for superficial subcutaneous transdermal drug delivery and a manufacturing method thereof.
背景技术Background technique
超声波技术与医疗技术的结合一直是近些年来的热点，典型的应用已有超声手术刀，B超，超声针灸探头和超声碎石等。与X光，核磁共振等电磁波技术不同，超声波本质上是机械波，在人体内的传播过程中可以迅速衰减，低强度超声并不会对人体造成任何影响。此外，已有研究表明，超声可以有效促进人体对药物的吸收，因此，将超声与透皮给药结合在一起成为当下的一个热门方向。The combination of ultrasonic technology and medical technology has been a hot topic in recent years. Typical applications include ultrasonic scalpels, B-ultrasound, ultrasonic acupuncture probes and ultrasonic lithotripsy. Unlike X-rays, nuclear magnetic resonance and other electromagnetic wave technologies, ultrasound waves are essentially mechanical waves that can rapidly attenuate during propagation in the human body. Low-intensity ultrasound will not have any impact on the human body. In addition, studies have shown that ultrasound can effectively promote the body's absorption of drugs. Therefore, combining ultrasound with transdermal drug delivery has become a popular direction at the moment.
目前关于透皮给药的技术中，关于换能器部分的设计大多未考虑到超声声场的分布，这样不可避免地在透皮给药过程给皮下深处的细胞带来损伤，因此有必要设计一种全新的换能器用于浅皮下透皮给药。In the current transdermal drug delivery technology, most designs of the transducer part do not take into account the distribution of the ultrasonic sound field. This will inevitably cause damage to cells deep under the skin during the transdermal drug delivery process. Therefore, it is necessary to design A novel transducer for superficial subcutaneous transdermal drug delivery.
发明内容Contents of the invention
有鉴于此，本发明创造旨在提出一种可用于浅皮下透皮给药的小型换能器及其制作方法，以解决现有换能器在透皮给药过程中给皮下深处细胞带来损伤的问题。In view of this, the invention aims to propose a small transducer that can be used for superficial subcutaneous transdermal drug delivery and a manufacturing method thereof, so as to solve the problem of existing transducers that bring cells deep under the skin during the process of transdermal drug delivery. to the question of injury.
为达到上述目的，本发明创造的技术方案是这样实现的：In order to achieve the above objectives, the technical solution created by the present invention is achieved as follows:
一种可用于浅皮下透皮给药的小型换能器，包括曲面匹配层、曲面压电陶瓷片和外壳，曲面压电陶瓷片的形状为凹面球冠形，所述曲面压电陶瓷片设置在金属外壳内，曲面压电陶瓷片的凹面朝上，凸面朝下，曲面压电陶瓷片与金属外壳之间通过环氧树脂粘接固定，曲面压电陶瓷片上表面电极与金属外壳以速干银浆连接导通，在曲面压电陶瓷的上表面铺设一层曲面匹配层，且曲面匹配层与压电陶瓷之间以环氧树脂粘接，所述曲面匹配层与曲面压电陶瓷形状相适应，在曲面压电陶瓷片的下表面与金属外壳的内壁上分别焊接一根导线，两根导线和信号源相连接。A small transducer that can be used for shallow subcutaneous transdermal drug delivery, including a curved surface matching layer, a curved surface piezoelectric ceramic sheet and a shell. The shape of the curved surface piezoelectric ceramic sheet is a concave spherical crown shape. The curved surface piezoelectric ceramic sheet is provided with In the metal shell, the concave surface of the curved piezoelectric ceramic sheet faces up and the convex surface faces down. The curved piezoelectric ceramic sheet and the metal shell are bonded and fixed by epoxy resin. The upper surface electrode of the curved piezoelectric ceramic sheet and the metal shell are connected at a high speed. The dry silver paste is connected and connected, and a curved matching layer is laid on the upper surface of the curved piezoelectric ceramic, and the curved matching layer and the piezoelectric ceramic are bonded with epoxy resin. The shape of the curved matching layer and the curved piezoelectric ceramic is Accordingly, a wire is welded on the lower surface of the curved piezoelectric ceramic sheet and the inner wall of the metal shell respectively, and the two wires are connected to the signal source.
更进一步的，所述曲面匹配层的材质为环氧树脂与钨粉混合物，声阻抗为7.25MRayl，厚度为4.785毫米。Furthermore, the material of the curved matching layer is a mixture of epoxy resin and tungsten powder, the acoustic impedance is 7.25MRayl, and the thickness is 4.785 mm.
更进一步的，所述曲面压电陶瓷片和曲面匹配层的截面均为球冠形。Furthermore, the cross-sections of the curved piezoelectric ceramic sheet and the curved matching layer are both spherical crown shapes.
更进一步的，所述曲面压电陶瓷片的厚度为2毫米，其中球冠高度为2毫米，球冠直径为20毫米。Furthermore, the thickness of the curved piezoelectric ceramic sheet is 2 mm, the height of the spherical cap is 2 mm, and the diameter of the spherical cap is 20 mm.
更进一步的，所述曲面匹配层的厚度为换能器工作频率的四分之一波长，其中球冠高度为2毫米，球冠直径为20毫米。Furthermore, the thickness of the curved surface matching layer is a quarter wavelength of the working frequency of the transducer, wherein the height of the spherical crown is 2 mm and the diameter of the spherical crown is 20 mm.
更进一步的，所述换能器采用径向振动模式，工作频率范围为90kHz-120kHz。Furthermore, the transducer adopts radial vibration mode and the operating frequency range is 90kHz-120kHz.
更进一步的，所述换能器产生的有效声场区域为：直径范围为2mm-8mm，深度范围为1mm-5mm。Furthermore, the effective sound field area generated by the transducer is: the diameter range is 2mm-8mm, and the depth range is 1mm-5mm.
更进一步的，所述换能器驱动信号为正弦波，频率为94.573kHz，产生的有效声场区域的直径为5.4mm，深度为2.2mm。Furthermore, the transducer drive signal is a sine wave with a frequency of 94.573kHz, and the effective sound field area generated has a diameter of 5.4mm and a depth of 2.2mm.
更进一步的，所述金属外壳为铝合金管，在曲面压电陶瓷片的凸面中心焊接一根导线，在铝合金管的内壁焊接一根导线。Furthermore, the metal shell is an aluminum alloy tube, a wire is welded to the center of the convex surface of the curved piezoelectric ceramic sheet, and a wire is welded to the inner wall of the aluminum alloy tube.
本申请还提供一种可用于浅皮下透皮给药的小型换能器的制作方法，具体包括以下步骤：This application also provides a method for making a small transducer that can be used for superficial subcutaneous transdermal drug delivery, which specifically includes the following steps:
S1、将曲面压电陶瓷片置于金属外壳内的所需位置，且曲面压电陶瓷片的凹面朝上，在曲面压电陶瓷片与金属外壳的缝隙处灌入环氧树脂，静置一段时间等待固化，待环氧树脂固化后，使用速干银浆连接金属外壳与曲面压电陶瓷片的凹面电极；静置一段时间，等待银浆充分固化，确保金属外壳与曲面压电陶瓷片的凹面电极电学导通；S1. Place the curved piezoelectric ceramic piece at the desired position in the metal shell, with the concave surface of the curved piezoelectric ceramic piece facing upward. Pour epoxy resin into the gap between the curved piezoelectric ceramic piece and the metal shell, and let it sit for a while. Wait for time to solidify. After the epoxy resin is solidified, use quick-drying silver paste to connect the metal shell and the concave electrode of the curved piezoelectric ceramic sheet. Leave it for a period of time and wait for the silver paste to fully solidify to ensure that the metal shell and the curved piezoelectric ceramic sheet are properly bonded. The concave electrode is electrically conductive;
S2、将橡胶管套于金属外壳上端，其中橡胶管部分与金属外壳接触，然后将环氧树脂与钨粉按一定比例搅拌均匀，并做除泡处理后将环氧树脂沿管壁倒入橡胶管中，保证环氧树脂与曲面压电陶瓷片的凹面相接触，静置一段时间等待环氧树脂固化，环氧树脂固化后除去橡胶管，再打磨曲面匹配层至指定形状；S2. Put the rubber tube on the upper end of the metal shell, with the rubber tube part in contact with the metal shell. Then mix the epoxy resin and tungsten powder evenly in a certain proportion, and after defoaming, pour the epoxy resin into the rubber along the tube wall. In the tube, ensure that the epoxy resin is in contact with the concave surface of the curved piezoelectric ceramic sheet, let it sit for a while and wait for the epoxy resin to solidify. After the epoxy resin solidifies, remove the rubber tube, and then polish the curved surface matching layer to the specified shape;
S3、在曲面压电陶瓷片的凸面中心处焊接一根导线，在金属外壳的内壁上焊接一根导线，至此完成换能器的制作。S3. Weld a wire at the center of the convex surface of the curved piezoelectric ceramic piece, and weld a wire on the inner wall of the metal shell. This completes the production of the transducer.
与现有技术相比，本发明创造所述的一种可用于浅皮下透皮给药的小型换能器的有益效果是：Compared with the existing technology, the beneficial effects of the small transducer that can be used for superficial subcutaneous transdermal drug delivery according to the invention are:
(1)本发明创造所述的一种可用于浅皮下透皮给药的小型换能器与普通换能器相比，本设计的换能器产生的超声作用深度较浅，能量利用率高，可以有效避免超声对皮下较深处的细胞损伤。(1) Compared with ordinary transducers, the small transducer described in the present invention that can be used for superficial subcutaneous transdermal drug delivery has a shallower depth of ultrasonic action and a higher energy utilization rate. , can effectively avoid ultrasound damage to cells deeper under the skin.
(2)本发明创造所述的一种可用于浅皮下透皮给药的小型换能器通过器件结构设计对超声的作用范围进行了控制；首先使用凹面陶瓷作为压电元件，比起平面陶瓷，凹面陶瓷基压电器件声束更为集中，声聚焦区域显著变短；其次通过陶瓷片直径的设计，对器件谐振频率进行调控，实现对声场的作用范围与作用深度的调制，尽可能避免超声波对皮下较深处细胞的影响。(2) The invention creates a small transducer that can be used for superficial subcutaneous transdermal drug delivery. The range of ultrasound action is controlled through device structure design; first, concave ceramics are used as piezoelectric elements. Compared with flat ceramics, , the sound beam of the concave ceramic-based piezoelectric device is more concentrated, and the sound focusing area is significantly shorter; secondly, through the design of the diameter of the ceramic piece, the resonant frequency of the device is controlled to achieve modulation of the range and depth of the sound field, and avoid as much as possible Effects of ultrasound on cells deeper under the skin.
(3)本发明创造提供的超声换能器，利用径向振动模式结合曲面陶瓷设计，可以在较小的器件尺寸下提供更大的超声作用面积，同时较小的驱动频率设计，大大减小了近场区域面积，确保超声作用深度较浅，避免了近场区域不稳定声场对人体的损伤作用。(3) The ultrasonic transducer provided by the invention utilizes the radial vibration mode combined with the curved ceramic design to provide a larger ultrasonic action area in a smaller device size. At the same time, the smaller drive frequency design greatly reduces the The area of the near-field area is increased to ensure that the depth of ultrasound action is shallow, and the damage to the human body caused by unstable sound fields in the near-field area is avoided.
附图说明Description of the drawings
构成本发明创造的一部分的附图用来提供对本发明创造的进一步理解，本发明创造的示意性实施例及其说明用于解释本发明创造，并不构成对本发明创造的不当限定。在附图中：The accompanying drawings that constitute a part of the present invention are used to provide a further understanding of the present invention. The illustrative embodiments of the present invention and their descriptions are used to explain the present invention and do not constitute an improper limitation of the present invention. In the attached picture:
图1为本发明创造实施例所述的一种可用于浅皮下透皮给药的小型换能器的立体结构示意图；Figure 1 is a schematic three-dimensional structural diagram of a small transducer that can be used for superficial subcutaneous transdermal drug delivery according to an embodiment of the present invention;
图2为本发明创造实施例所述的一种可用于浅皮下透皮给药的小型换能器的剖面图；Figure 2 is a cross-sectional view of a small transducer that can be used for superficial subcutaneous transdermal drug delivery according to an embodiment of the present invention;
图3为本发明创造实施例所述的一种可用于浅皮下透皮给药的小型换能器的曲面压电陶瓷的结构示意图；Figure 3 is a schematic structural diagram of a curved piezoelectric ceramic of a small transducer that can be used for superficial subcutaneous transdermal drug delivery according to the creative embodiment of the present invention;
图4为本发明创造实施例所述的一种可用于浅皮下透皮给药的小型换能器的曲面匹配层的结构示意图；Figure 4 is a schematic structural diagram of a curved matching layer of a small transducer that can be used for superficial subcutaneous transdermal drug delivery according to an embodiment of the present invention;
图5为本发明创造实施例所述的一种可用于浅皮下透皮给药的小型换能器的阻抗谱；Figure 5 is the impedance spectrum of a small transducer that can be used for superficial subcutaneous transdermal drug delivery according to the creative embodiment of the present invention;
图6为本发明创造实施例所述的一种可用于浅皮下透皮给药的小型换能器的声压分布图；Figure 6 is a sound pressure distribution diagram of a small transducer that can be used for superficial subcutaneous transdermal drug delivery according to the creative embodiment of the present invention;
图7为本发明创造实施例所述的一种可用于浅皮下透皮给药的小型换能器的轴向声压分布图。Figure 7 is an axial sound pressure distribution diagram of a small transducer that can be used for superficial subcutaneous transdermal drug delivery according to the creative embodiment of the present invention.
附图标记说明：Explanation of reference symbols:
1、曲面匹配层；2、曲面压电陶瓷片；3、外壳；4、导线。1. Curved surface matching layer; 2. Curved surface piezoelectric ceramic sheet; 3. Shell; 4. Wires.
具体实施方式Detailed ways
下面将结合附图对本发明创造的技术方案进行清楚、完整地描述，显然，所描述的实施例是本发明创造一部分实施例，而不是全部的实施例。基于本发明创造中的实施例，本领域普通技术人员在没有做出创造性劳动前提下所获得的所有其他实施例，都属于本发明创造保护的范围。The technical solutions created by the present invention will be clearly and completely described below with reference to the accompanying drawings. Obviously, the described embodiments are some, not all, of the embodiments of the present invention. Based on the embodiments of the present invention, all other embodiments obtained by those of ordinary skill in the art without creative efforts shall fall within the scope of protection of the present invention.
在本发明创造的描述中，需要说明的是，术语“中心”、“上”、“下”、“左”、“右”、“竖直”、“水平”、“内”、“外”等指示的方位或位置关系为基于附图所示的方位或位置关系，仅是为了便于描述本发明创造和简化描述，而不是指示或暗示所指的装置或元件必须具有特定的方位、以特定的方位构造和操作，因此不能理解为对本发明创造的限制。此外，术语“第一”、“第二”、“第三”仅用于描述目的，而不能理解为指示或暗示相对重要性。In the description of the present invention, it should be noted that the terms "center", "upper", "lower", "left", "right", "vertical", "horizontal", "inner" and "outer" The indicated orientations or positional relationships are based on the orientations or positional relationships shown in the drawings. They are only for the convenience of describing the present invention and simplifying the description. They are not intended to indicate or imply that the device or element referred to must have a specific orientation or a specific orientation. The orientation, construction and operation of the invention should not be construed as limitations on the invention. Furthermore, the terms “first”, “second” and “third” are used for descriptive purposes only and are not to be construed as indicating or implying relative importance.
在本发明创造的描述中，需要说明的是，除非另有明确的规定和限定，术语“安装”、“相连”、“连接”应做广义理解，例如，可以是固定连接，也可以是可拆卸连接，或一体地连接；可以是机械连接，也可以是电连接；可以是直接相连，也可以通过中间媒介间接相连，可以是两个元件内部的连通。对于本领域的普通技术人员而言，可以具体情况理解上述术语在本发明创造中的具体含义。In the description of the present invention, it should be noted that, unless otherwise clearly stated and limited, the terms "installation", "connection" and "connection" should be understood in a broad sense. For example, it can be a fixed connection or a removable connection. Detachable connection, or integral connection; it can be a mechanical connection or an electrical connection; it can be a direct connection or an indirect connection through an intermediate medium; it can be an internal connection between two components. For those of ordinary skill in the art, the specific meanings of the above terms in the present invention can be understood in specific situations.
此外，下面所描述的本发明创造不同实施方式中所涉及的技术特征只要彼此之间未构成冲突就可以相互结合。In addition, the technical features involved in different embodiments of the present invention described below can be combined with each other as long as they do not conflict with each other.
如图1-图4所示，一种可用于浅皮下透皮给药的小型换能器，包括曲面匹配层1、曲面压电陶瓷片2和外壳3，曲面压电陶瓷片2的形状为凹面球冠形，所述曲面压电陶瓷片2设置在金属外壳3内，曲面压电陶瓷片2的凹面朝上，凸面朝下，曲面压电陶瓷片2与金属外壳3之间通过环氧树脂粘接固定，曲面压电陶瓷片2上表面电极与金属外壳3以速干银浆连接导通，在曲面压电陶瓷的上表面铺设一层曲面匹配层1，且曲面匹配层1与压电陶瓷之间以环氧树脂粘接，所述曲面匹配层1与曲面压电陶瓷形状相适应，在曲面压电陶瓷片2的下表面与金属外壳3的内壁上分别焊接一根导线，两根导线和信号源相连接。As shown in Figures 1 to 4, a small transducer that can be used for superficial subcutaneous transdermal drug delivery includes a curved matching layer 1, a curved piezoelectric ceramic sheet 2 and a shell 3. The shape of the curved piezoelectric ceramic sheet 2 is: Concave spherical crown shape, the curved surface piezoelectric ceramic sheet 2 is arranged in the metal shell 3, the concave surface of the curved surface piezoelectric ceramic sheet 2 faces upward, and the convex surface faces downward. The curved surface piezoelectric ceramic sheet 2 and the metal shell 3 are connected by a ring. Oxygen resin is bonded and fixed, the upper surface electrode of the curved piezoelectric ceramic piece 2 is connected to the metal shell 3 with quick-drying silver paste, and a curved surface matching layer 1 is laid on the upper surface of the curved piezoelectric ceramic, and the curved surface matching layer 1 and The piezoelectric ceramics are bonded with epoxy resin. The curved surface matching layer 1 is adapted to the shape of the curved surface piezoelectric ceramics. A wire is welded to the lower surface of the curved surface piezoelectric ceramic sheet 2 and the inner wall of the metal shell 3 respectively. Two wires are connected to the signal source.
本申请的换能器与普通换能器相比，本设计的换能器产生的超声作用深度较浅，能量利用率高，可以有效避免超声对皮下较深处的细胞损伤。Compared with ordinary transducers, the transducer of this application has a shallower depth of ultrasonic action and a high energy utilization rate, which can effectively avoid ultrasonic damage to cells deeper under the skin.
所述曲面匹配层1的材质为环氧树脂与钨粉混合物，声阻抗为7.25MRayl，厚度为4.785毫米。The material of the curved matching layer 1 is a mixture of epoxy resin and tungsten powder, the acoustic impedance is 7.25MRayl, and the thickness is 4.785 mm.
所述曲面压电陶瓷片2和曲面匹配层1的截面均为球冠形。所述曲面压电陶瓷片2的厚度为2毫米，其中球冠高度为2毫米，球冠直径为20毫米。所述曲面匹配层1的厚度为换能器工作频率的四分之一波长，其中球冠高度为2毫米，球冠直径为20毫米。The cross-sections of the curved piezoelectric ceramic sheet 2 and the curved matching layer 1 are both spherical. The thickness of the curved piezoelectric ceramic sheet 2 is 2 mm, the height of the spherical crown is 2 mm, and the diameter of the spherical crown is 20 mm. The thickness of the curved matching layer 1 is a quarter wavelength of the working frequency of the transducer, where the spherical cap height is 2 mm and the spherical cap diameter is 20 mm.
所述换能器采用径向振动模式，工作频率范围为90kHz-120kHz。所述换能器产生的有效声场区域为：直径范围为2mm-8mm，深度范围为1mm-5mm。所述换能器驱动信号为正弦波，频率为94.573kHz，产生的有效声场区域的直径为5.4mm，深度为2.2mm。The transducer adopts radial vibration mode and the operating frequency range is 90kHz-120kHz. The effective sound field area generated by the transducer is: a diameter range of 2mm-8mm, and a depth range of 1mm-5mm. The transducer drive signal is a sine wave with a frequency of 94.573kHz, and the effective sound field area generated has a diameter of 5.4mm and a depth of 2.2mm.
所述金属外壳3为铝合金管，在曲面压电陶瓷片2的凸面中心焊接一根导线4，在铝合金管的内壁焊接一根导线4。The metal shell 3 is an aluminum alloy tube. A wire 4 is welded to the center of the convex surface of the curved piezoelectric ceramic sheet 2, and a wire 4 is welded to the inner wall of the aluminum alloy tube.
与普通换能器相比，本申请的换能器产生的超声作用深度较浅，能量利用率高，可以有效避免超声对皮下较深处的细胞损伤，对超声作用范围进行控制，减少无效超声对人体的影响。Compared with ordinary transducers, the ultrasound produced by the transducer of the present application has a shallower depth of action and a high energy utilization rate. It can effectively avoid ultrasound damage to cells deeper under the skin, control the range of ultrasound action, and reduce ineffective ultrasound. Effects on the human body.
一种可用于浅皮下透皮给药的小型换能器的制作方法，具体包括以下步骤：A method for making a small transducer that can be used for superficial subcutaneous transdermal drug delivery, specifically including the following steps:
S1、将曲面压电陶瓷片2置于金属外壳3内的所需位置，且曲面压电陶瓷片2的凹面朝上，在曲面压电陶瓷片2与金属外壳3的缝隙处灌入环氧树脂，静置一段时间等待固化，待环氧树脂固化后，使用速干银浆连接金属外壳3与曲面压电陶瓷片2的凹面电极；静置一段时间，等待银浆充分固化，确保金属外壳3与曲面压电陶瓷片2的凹面电极电学导通；S1. Place the curved piezoelectric ceramic sheet 2 at the desired position in the metal shell 3 with the concave surface of the curved piezoelectric ceramic sheet 2 facing upward. Pour epoxy into the gap between the curved piezoelectric ceramic sheet 2 and the metal shell 3. Resin, wait for a period of time to solidify. After the epoxy resin solidifies, use quick-drying silver paste to connect the metal shell 3 and the concave electrode of the curved piezoelectric ceramic sheet 2; wait for a period of time, wait for the silver paste to fully solidify, and ensure that the metal shell 3 is electrically connected to the concave electrode of the curved piezoelectric ceramic sheet 2;
S2、将橡胶管套于金属外壳3上端，其中橡胶管部分与金属外壳3接触，然后将环氧树脂与钨粉按一定比例搅拌均匀，并做除泡处理后将环氧树脂沿管壁倒入橡胶管中，保证环氧树脂与曲面压电陶瓷片2的凹面相接触，静置一段时间等待环氧树脂固化，环氧树脂固化后除去橡胶管，再打磨曲面匹配层1至指定形状；S2. Put the rubber tube on the upper end of the metal shell 3, with the part of the rubber tube in contact with the metal shell 3. Then mix the epoxy resin and tungsten powder evenly in a certain proportion, and perform defoaming treatment before pouring the epoxy resin along the tube wall. Put it into the rubber tube, ensure that the epoxy resin is in contact with the concave surface of the curved piezoelectric ceramic sheet 2, let it sit for a while and wait for the epoxy resin to solidify. After the epoxy resin solidifies, remove the rubber tube, and then polish the curved surface matching layer 1 to the specified shape;
S3、在曲面压电陶瓷片2的凸面中心处焊接一根导线，在金属外壳3的内壁上焊接一根导线，至此完成换能器的制作。S3. Weld a wire at the center of the convex surface of the curved piezoelectric ceramic sheet 2, and weld a wire on the inner wall of the metal shell 3. This completes the production of the transducer.
下面给出一种具体的可用于浅皮下透皮给药的小型换能器制备方法，包括以下步骤：The following is a specific preparation method of a small transducer that can be used for superficial subcutaneous transdermal drug delivery, including the following steps:
S1、将球冠高度为2毫米，球冠直径为20毫米，厚度为2毫米的曲面压电陶瓷片2置于内径为20.5毫米，外径为21.5毫米，高度为25毫米的铝合金管中的所需位置，即距离铝合金管的上端面5mm位置处，且曲面压电陶瓷片2的凹面朝上，在曲面压电陶瓷片2与金属外壳3的缝隙处灌入环氧树脂，静置24h等待固化，待环氧树脂固化后，使用速干银浆连接金属外壳3与曲面压电陶瓷片2的凹面电极；静置4h，等待银浆充分固化，确保金属外壳3与曲面压电陶瓷片2的凹面电极电学导通；S1. Place the curved piezoelectric ceramic piece 2 with a spherical crown height of 2 mm, a spherical crown diameter of 20 mm, and a thickness of 2 mm into an aluminum alloy tube with an inner diameter of 20.5 mm, an outer diameter of 21.5 mm, and a height of 25 mm. The required position is 5mm away from the upper end surface of the aluminum alloy tube, and the concave surface of the curved piezoelectric ceramic sheet 2 is facing upward. Pour epoxy resin into the gap between the curved piezoelectric ceramic sheet 2 and the metal shell 3, and let it sit Leave it for 24 hours and wait for solidification. After the epoxy resin solidifies, use quick-drying silver paste to connect the metal shell 3 and the concave electrode of the curved piezoelectric ceramic sheet 2; leave it for 4 hours and wait for the silver paste to fully solidify to ensure that the metal shell 3 and the curved piezoelectric ceramic sheet 2 are connected. The concave electrode of the ceramic sheet 2 is electrically conductive;
S2、将长6毫米，直径为21毫米的橡胶管套于金属外壳3上端，其中橡胶管部分与金属外壳3接触，然后将环氧树脂与钨粉按质量比1：5搅拌均匀，并做除泡处理后将环氧树脂沿管壁倒入橡胶管中，静置24h等待环氧树脂固化，环氧树脂固化后除去橡胶管，再打磨曲面匹配层1至指定形状；S2. Put a rubber tube with a length of 6 mm and a diameter of 21 mm on the upper end of the metal shell 3. The rubber tube part is in contact with the metal shell 3. Then mix the epoxy resin and tungsten powder evenly according to the mass ratio of 1:5, and make After the defoaming process, pour the epoxy resin into the rubber tube along the tube wall, let it sit for 24 hours and wait for the epoxy resin to solidify. After the epoxy resin solidifies, remove the rubber tube, and then polish the curved surface matching layer 1 to the specified shape;
S3、在曲面压电陶瓷片2的凸面中心处焊接一根导线，在金属外壳3的内壁上焊接一根导线，至此完成换能器的制作。S3. Weld a wire at the center of the convex surface of the curved piezoelectric ceramic sheet 2, and weld a wire on the inner wall of the metal shell 3. This completes the production of the transducer.
如图5所示为一种可用于浅皮下透皮给药的小型换能器的阻抗谱，根据阻抗谱确定换能器驱动信号频率为94.573kHz；Figure 5 shows the impedance spectrum of a small transducer that can be used for superficial subcutaneous transdermal drug delivery. According to the impedance spectrum, the frequency of the transducer driving signal is determined to be 94.573kHz;
对上述制作的换能器发出的声场，如图6的一种可用于浅皮下透皮给药的小型换能器的声压分布图所示，可以看出声场主要分布在直径5.4毫米范围内，之后强度迅速下降；Regarding the sound field emitted by the above-mentioned transducer, as shown in Figure 6, the sound pressure distribution diagram of a small transducer that can be used for superficial subcutaneous transdermal drug delivery, it can be seen that the sound field is mainly distributed in the diameter range of 5.4 mm. within, and then the intensity drops rapidly;
对上述制作的换能器发出的声场，如图7的一种可用于浅皮下透皮给药的小型换能器的轴向声压分布图，通过图5-图7的结果可以得出：声场主要分布在皮下2.2毫米深度范围内，之后强度迅速下降。Regarding the sound field emitted by the above-mentioned transducer, as shown in Figure 7, the axial sound pressure distribution diagram of a small transducer that can be used for superficial subcutaneous transdermal drug delivery. From the results in Figures 5 to 7, it can be concluded that: The sound field is mainly distributed within the depth range of 2.2 mm under the skin, and then the intensity decreases rapidly.
通过以上图表明，本申请的一种换能器能够大大减小近场区域面积，确保超声作用深度较浅，避免了近场区域不稳定声场对人体的损伤作用，特别适用于浅皮下透皮给药操作。The above figure shows that the transducer of this application can greatly reduce the area of the near-field area, ensure that the depth of ultrasound action is shallow, and avoid the damaging effects of unstable sound fields in the near-field area on the human body. It is especially suitable for shallow subcutaneous transdermal applications. Dosing operations.
以上公开的本发明创造实施例只是用于帮助阐述本发明。实施例并没有详尽叙述所有的细节，也不限制该发明创造仅为所述的具体实施方式。根据本说明书的内容，可作很多的修改和变化。本说明书选取并具体描述这些实施例，是为了更好地解释本发明创造的原理和实际应用，从而使所属技术领域技术人员能很好地理解和利用本发明创造。The creative embodiments of the present invention disclosed above are only used to help explain the present invention. The embodiments do not exhaustively describe all the details, nor do they limit the invention to the described specific implementations. Many modifications and changes may be made based on the contents of this manual. This specification selects and specifically describes these embodiments to better explain the principles and practical applications of the present invention, so that those skilled in the art can better understand and utilize the present invention.
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202210550607.1ACN115105738B (en) | 2022-05-20 | 2022-05-20 | A small transducer that can be used for superficial subcutaneous transdermal drug delivery and a manufacturing method thereof |
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202210550607.1ACN115105738B (en) | 2022-05-20 | 2022-05-20 | A small transducer that can be used for superficial subcutaneous transdermal drug delivery and a manufacturing method thereof |
| Publication Number | Publication Date |
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| CN115105738A CN115105738A (en) | 2022-09-27 |
| CN115105738Btrue CN115105738B (en) | 2024-03-19 |
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202210550607.1AActiveCN115105738B (en) | 2022-05-20 | 2022-05-20 | A small transducer that can be used for superficial subcutaneous transdermal drug delivery and a manufacturing method thereof |
| Country | Link |
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| CN (1) | CN115105738B (en) |
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN115624690B (en)* | 2022-10-14 | 2023-10-31 | 江苏省声学产业技术创新中心 | Bowl-shaped piezoelectric ceramic structure for transdermal drug delivery instrument and application thereof |
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| CN2796747Y (en)* | 2005-05-26 | 2006-07-19 | 深圳市普罗惠仁医学科技有限公司 | Spherical crown type concave ball surface ultrasonic transducer |
| CN102580261A (en)* | 2012-03-31 | 2012-07-18 | 上海交通大学 | Focusing ultrasonic transducer device for treating superficial tumor |
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| US7824348B2 (en)* | 2004-09-16 | 2010-11-02 | Guided Therapy Systems, L.L.C. | System and method for variable depth ultrasound treatment |
| CA2799760C (en)* | 2010-05-21 | 2019-10-08 | Misonix Incorporated | Ultrasonic transducer assembly |
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN2796747Y (en)* | 2005-05-26 | 2006-07-19 | 深圳市普罗惠仁医学科技有限公司 | Spherical crown type concave ball surface ultrasonic transducer |
| CN102580261A (en)* | 2012-03-31 | 2012-07-18 | 上海交通大学 | Focusing ultrasonic transducer device for treating superficial tumor |
| Publication number | Publication date |
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| CN115105738A (en) | 2022-09-27 |
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