Disclosure of Invention
The invention mainly aims to provide a femoral stem, which solves the problem that an artificial hip joint prosthesis loosens due to long-time osseous disunion in the related art, and the medicine in the accommodating cavity can be one of an anti-infection medicine, a bone promoting medicine, an anti-osteoporosis medicine and an anti-tumor medicine, so that a doctor can select according to the actual situation of a patient, and the femoral stem can also provide assistance for corresponding treatment.
The femoral stem comprises a stem body, a medicine carrying container and a medicine carrying container, wherein the stem body is provided with an installation part, the medicine carrying container is fixedly installed on the installation part and is provided with a containing cavity for containing medicine, the medicine carrying container is provided with an overflow hole and a slow release hole which are communicated with the containing cavity at intervals, the stem body is internally provided with a medicine control cavity with variable volume, the overflow hole is communicated with the medicine control cavity, the slow release hole is communicated with the outside of the stem body, the medicine control cavity comprises a plurality of cavity sections which are sequentially communicated, and the volume of each cavity section is different.
Further, each cavity section comprises a first cambered surface and a second cambered surface opposite to the opening direction of the first cambered surface, and the distance between the first cambered surface and the second cambered surface is gradually reduced under the condition that the handle body is stressed.
Further, one side of the first cambered surface closest to the handle body midline in the cavity sections is connected with one side of the second cambered surface, an open port is formed between one side of the first cambered surface farthest from the handle body midline in the cavity sections and one side of the second cambered surface, the overflow hole is positioned at the open port, the number of the cavity sections is three between the outside of the handle body and the handle body midline, the volume of the cavity section positioned in the middle in the three cavity sections is minimum, and the radian of the first cambered surface of the cavity section positioned in the middle is maximum.
Further, the installation part is an installation concave cavity, the medicine carrying container is a first medicine carrying ellipsoid, and the first medicine carrying ellipsoid is connected with the installation concave cavity in an interference mode.
Further, the slow release holes are multiple, and the multiple slow release holes are arranged on the first medicine carrying ellipsoid at intervals.
Further, the installation part is a sphere-shaped cavity, the medicine carrying container is a second medicine carrying ellipsoid, and the second medicine carrying ellipsoid is connected with the sphere-shaped cavity in an interference way.
Further, the overflow hole and the slow release hole are one each.
Further, the installation department is the cylindricality chamber, and the medicine carrying container is the medicine carrying pipe, and medicine carrying pipe interference connection is in the cylindricality chamber, and the overflow hole is located the first end in cylindricality chamber, and the slow-release hole is located the second end in cylindricality chamber.
Further, the medicine carrying tube is of a polyhedral structure.
Further, the diameter of the overflow hole and/or the diameter of the slow release hole are/is in the range of 100-800 micrometers, when the medicine carrying container is an ellipsoid carrying body, the outer diameter of the short axis of the ellipsoid carrying body is in the range of 0.5-3 mm, the inner diameter of the short axis of the ellipsoid carrying body is in the range of 0.3-2.5 mm, when the medicine carrying container is a medicine carrying tube, the inner diameter of the medicine carrying tube is in the range of 0.05-0.5 mm, the height of the medicine carrying tube is in the range of 1-3 mm, and the outer surface of the handle body and the outer surface of the medicine carrying container are both covered with the anti-overflow layer.
Further, the installation department is a plurality of, and a plurality of installation department is arranged into the multilayer around the handle body interval, and the medicine container is a plurality of, and a plurality of medicine containers and a plurality of installation department one-to-one set up, and accuse medicine chamber is a plurality of, and a plurality of medicine containers and a accuse medicine chamber that lie in same layer in a plurality of medicine containers correspond the setting, or a plurality of medicine containers and a plurality of accuse medicine chamber that lie in same layer in the medicine container one-to-one set up.
Further, when a plurality of medicine carrying containers positioned on the same layer are correspondingly arranged with one medicine control cavity, the number of cavity sections of each medicine control cavity comprises two, the first cavity section comprises a first annular cambered surface and a second annular cambered surface opposite to the opening direction of the first annular cambered surface, an annular opening is formed between the first annular cambered surface and the second annular cambered surface, the overflow holes of the medicine carrying containers positioned on the same layer in the plurality of medicine carrying containers are positioned at the annular opening, the second cavity section comprises a first plane and a second plane which are arranged at intervals up and down, the first plane is connected to the inner side of the first annular cambered surface, and the second plane is connected to the inner side of the second annular cambered surface.
By applying the technical scheme of the application, the femoral stem comprises a stem body and a medicine carrying container. The handle body is provided with an installation part. The medicine carrying container is fixedly arranged on the mounting part and is provided with a containing cavity for containing medicine, and the medicine carrying container is provided with an overflow hole and a slow release hole which are communicated with the containing cavity at intervals. Therefore, the accommodating cavity of the medicine carrying container is used for carrying medicine independently, so that calculation is convenient, the total medicine carrying amount is controlled, and meanwhile, the size of the medicine carrying container is also convenient to design, so that the handle bodies with different shapes and sizes can be adapted. In the application, a medicine control cavity with variable volume is arranged in the handle body, the overflow hole is communicated with the medicine control cavity, the slow release hole is communicated with the outside of the handle body, wherein the medicine control cavity comprises a plurality of cavity sections which are sequentially communicated, and the volume of each cavity section is different. The femoral stem can be implanted to the fracture periphery of the human body, the medicine is loaded in the accommodating cavity of the medicine-carrying container, and the medicine acts on the fracture through the slow-release hole, so that the fracture periphery has good blood circulation, and the bone healing time is shortened. Thereby reducing the possibility of loosening the artificial hip joint prosthesis and providing assistance for the curative effect of open wounds according to the type of the medicine carried in the medicine carrying container. Therefore, the technical scheme of the application can solve the problem that the artificial hip joint prosthesis is loosened due to long-time osseous disunion in the related technology. In addition, when the handle body is stressed and bent in the process of osseous healing, the volume of the medicine control cavity is reduced from large to small, and a medium in the medicine control cavity overflows into the accommodating cavity through the flow hole to push the medicine, so that the release of the medicine from the slow release hole is accelerated, when the fracture is not healed or the patient moves more, the release amount of the medicine is larger, the blood circulation environment around the fracture is greatly improved, the osseous healing time can be effectively shortened, and the possibility of loosening the artificial hip joint prosthesis is greatly reduced. And when the fracture is not healed or the patient moves more, as the medicine control cavity comprises a plurality of cavity sections which are sequentially communicated, the volume of each cavity section is different, and the speed of the control medium overflowing into the accommodating cavity through the flow holes is different, the release amount of the accelerating medicine from the slow release holes can be reasonably controlled according to the fracture is not healed or the patient moves, and the blood circulation environment around the fracture is effectively improved.
Detailed Description
The following description of the embodiments of the present invention will be made clearly and completely with reference to the accompanying drawings, in which it is apparent that the embodiments described are only some embodiments of the present invention, but not all embodiments. The following description of at least one exemplary embodiment is merely exemplary in nature and is in no way intended to limit the invention, its application, or uses. All other embodiments, which can be made by those skilled in the art based on the embodiments of the invention without making any inventive effort, are intended to be within the scope of the invention.
It is noted that the terminology used herein is for the purpose of describing particular embodiments only and is not intended to be limiting of exemplary embodiments according to the present application. As used herein, the singular is also intended to include the plural unless the context clearly indicates otherwise, and furthermore, it is to be understood that the terms "comprises" and/or "comprising" when used in this specification are taken to specify the presence of stated features, steps, operations, devices, components, and/or combinations thereof.
The relative arrangement of the components and steps, numerical expressions and numerical values set forth in these embodiments do not limit the scope of the present invention unless it is specifically stated otherwise. Meanwhile, it should be understood that the sizes of the respective parts shown in the drawings are not drawn in actual scale for convenience of description. Techniques, methods, and apparatus known to one of ordinary skill in the relevant art may not be discussed in detail, but should be considered part of the specification where appropriate. In all examples shown and discussed herein, any specific values should be construed as merely illustrative, and not a limitation. Thus, other examples of the exemplary embodiments may have different values. It should be noted that like reference numerals and letters refer to like items in the following figures, and thus once an item is defined in one figure, no further discussion thereof is necessary in subsequent figures.
As shown in fig. 1 to 12, the femoral stem of the present embodiment includes a stem body 102 and a medicine-carrying container 20. The handle 102 is provided with a mounting portion. The medicine-carrying container 20 is fixedly mounted on the mounting portion, the medicine-carrying container 20 has a containing chamber for containing medicine, and the medicine-carrying container 20 is provided with an overflow hole 24 and a slow release hole 25 which are communicated with the containing chamber at intervals. Wherein, the handle body 102 is internally provided with a medicine control cavity 11 with variable volume, the overflow hole 24 is communicated with the medicine control cavity 11, the slow release hole 25 is communicated with the outside of the handle body 102, wherein, the medicine control cavity 11 comprises a plurality of cavity sections which are communicated in sequence, and the volume of each cavity section is different.
By applying the technical scheme of the embodiment, the medicine carrying container 20 is fixedly arranged on the mounting part, the medicine carrying container 20 is provided with a containing cavity for containing medicine, and the medicine carrying container 20 is provided with an overflow hole 24 and a slow release hole 25 which are communicated with the containing cavity at intervals. In this way, the accommodating cavity of the medicine-carrying container 20 is used for carrying medicine alone, so that calculation is convenient, the total medicine carrying amount is controlled, and meanwhile, the size of the medicine-carrying container 20 is also convenient to design so as to adapt to the handle body 102 with different shapes and sizes. In this embodiment, a medicine control chamber 11 with a variable volume is disposed in the handle body 102, the overflow hole 24 is communicated with the medicine control chamber 11, the slow release hole 25 is communicated with the outside of the handle body 102, wherein the medicine control chamber 11 comprises a plurality of chamber sections which are sequentially communicated, and the volume of each chamber section is different. The femoral stem can be implanted to the periphery of the fracture of the human body, the medicine is loaded in the accommodating cavity of the medicine-carrying container 20, and the medicine acts on the fracture through the slow release hole 25, so that the periphery of the fracture has good blood circulation, and the bone healing time is shortened. Thereby reducing the possibility of loosening the artificial hip joint prosthesis and providing assistance for the curative effect of open wounds according to the type of the medicine carried in the medicine carrying container. Therefore, the technical scheme of the embodiment can solve the problem that the artificial hip joint prosthesis is loosened due to long-time osseous disunion in the related technology. In addition, when the handle body 102 is stressed by F to bend in the bone healing process, the medicine control cavity 11 is compressed, the volume of the medicine control cavity 11 is reduced from large to small, a medium in the medicine control cavity 11 overflows into the accommodating cavity through the flow hole 24 to push medicine, release of the medicine from the slow release hole 25 is accelerated, when the fracture is not healed or the patient moves more, the release amount of the medicine is larger, the blood circulation environment around the fracture is greatly improved, the bone healing time can be effectively shortened, and the possibility of loosening the artificial hip joint prosthesis is greatly reduced. Thus, the patient does not need to carry out secondary revision surgery, and secondary injury can be reduced and the generation of a large amount of clinical cost can be eliminated. And when the fracture is not healed or the patient moves more, as the medicine control cavity 11 comprises a plurality of cavity sections which are communicated in sequence, the volume of each cavity section is different, and the speed of the control medium overflowing into the accommodating cavity through the flow hole 24 is different, the release amount of the accelerating medicine from the slow release hole 25 can be reasonably controlled according to the fracture is not healed or the patient moves, and the blood transportation environment around the fracture is effectively improved.
It should be noted that, the "variable volume" refers to that after the handle 102 is stressed, the volume of the medicine control chamber 11 can be changed from large to small along with the gradual increase of the acting force, and the volume of the medicine control chamber 11 can be changed from small to large along with the gradual decrease of the acting force. The medium in the medicine control cavity 11 can be granular medicine, powder medicine or liquid medicine, wherein the liquid medicine is anti-infection medicine, bone promoting medicine or osteoporosis treating medicine. Specifically, the medicine in the medicine-carrying container 20 is determined according to the medicine in the medicine-carrying container 20, that is, the medicine in the medicine-carrying container 20 and the medium in the medicine-controlling cavity 11 are the same medicine.
The handle 102 and the drug delivery container 20 of the present embodiment may be cast or 3D printed. Wherein, the handle body 102 and the medicine-carrying container 20 are of a one-step molding structure, namely, are formed into one part.
The femoral stem of the embodiment is implanted around the cervical fracture of the femur 2, and the medicine in the accommodating cavity of the medicine carrying container 20 acts on the fracture through the slow release hole 25, so that the blood circulation around the fracture is good, and the osseous healing time is shortened. The handle 102 is made of medical metal, including but not limited to titanium and titanium alloy, cobalt alloy, stainless steel, tantalum metal and magnesium alloy, which are specified in international standard of ISO-5830 series, and the biocompatibility of the medical metal is proved by practice of orthopedic implantation application for many years at home and abroad. The shank 102 may also be implanted in a region of a tibia, humerus, radius, etc. where there is a risk of fracture of the extremities.
When the fracture of the human body occurs, the proper specification of the handle body 102 is selected according to the fracture position, and the drug carrying container 20 on the handle body 102 is matched with the proximal medullary cavity of the femur 2 according to the anatomical matching position relation, so that the drug release of the slow release hole 25 of the drug carrying container 20 can be ensured to directly act on the fracture position of the proximal femur, and the purpose of low dosage and high efficiency is realized.
As shown in fig. 9 and 12, each cavity section includes a first arc surface 111 and a second arc surface 112 opposite to the opening of the first arc surface 111, and the distance between the first arc surface 111 and the second arc surface 112 gradually decreases under the condition that the handle 102 is stressed F. The shapes of the first cambered surface 111 and the second cambered surface 112 ensure that the medicine control cavity 11 has a certain supporting force, and the stability of the internal structure of the handle body 102 can be ensured when the medicine control cavity 11 is stressed and deformed. It should be noted that, the first cambered surface 111 and the second cambered surface 112 may be arch bridge-shaped or spherical segment-shaped.
As shown in fig. 9 and 12, when the handle 102 is bent under the force F, the medicine control cavity 11 is compressed, because one side of the first cambered surface 111 closest to the center line L of the handle 102 in the cavity sections is connected with one side of the second cambered surface 112, an open opening is formed between one side of the first cambered surface 111 farthest from the center line L of the handle 102 in the cavity sections and one side of the second cambered surface 112, and the overflow hole 24 is located at the open opening, so that the connection between one side of the first cambered surface 111 and one side of the second cambered surface 112 is closed, and the medium in the medicine control cavity 11 can only flow out from the open opening and enter the overflow hole 24, so that the medicine control cavity 11 can provide larger thrust to accelerate the release of medicine, when the fracture is not healed or the patient moves more, the medicine release amount in the accommodating cavity is larger, otherwise the medicine release amount in the accommodating cavity is smaller, and the medicine release condition can be dynamically controlled according to the actual condition of the patient. In order to more accurately control the rate of medium flow through the flow aperture 24 into the receiving cavity, the number of cavity segments is three between the exterior of the shank 102 and the centerline L of the shank 102, with the middle of the three cavity segments having the smallest volume and the middle cavity segment having the largest arc of the first arcuate surface 111. In addition, the volume of the one of the three cavity segments closest to the centerline L of the handle 102 is less than the volume of the one of the three cavity segments furthest from the centerline L of the handle 102, and the arc of the first arc 111 of the three cavity segments closest to the centerline L of the handle 102 is less than the arc of the first arc 111 of the three cavity segments furthest from the centerline L of the handle 102.
In this embodiment, when the medicine-carrying container 20 is an ellipsoid, the outer diameter of the short axis of the ellipsoid is in the range of 0.5mm to 3mm, the inner diameter of the short axis of the ellipsoid is in the range of 0.3mm to 2.5mm, and when the medicine-carrying container 20 is a tube, the inner diameter of the tube is in the range of 0.05mm to 0.5mm, and the height of the tube is in the range of 1mm to 3 mm.
In this embodiment, the drug is one of an anti-infection drug, a bone-promoting drug, an anti-osteoporosis drug and an anti-tumor drug, and a doctor can select according to the actual situation of the patient, so that the femoral stem can also provide assistance for corresponding treatment.
As shown in fig. 3 and 6, the mounting portion is a mounting cavity, the medicine-carrying container 20 is a first medicine-carrying ellipsoid 21, and the first medicine-carrying ellipsoid 21 is connected to the mounting cavity in an interference manner. Thus, at least half of the first drug-carrying ellipsoid 21 is exposed outside the outer surface of the handle body 102, and when the anti-infective drug is loaded in the first drug-carrying ellipsoid 21, the anti-infective drug in the first drug-carrying ellipsoid 21 acts on the fracture through the slow release hole 25, so that anti-infective effect can be realized, good blood circulation around the fracture can be realized, and the osseous healing time can be effectively shortened. The anti-infective agents described above include, but are not limited to, gentamicin, vancomycin, meropenem, voriconazole. The outside diameter of the short axis of the first drug-carrying ellipsoid 21 is in the range of 0.5mm to 1.5 mm.
It should be noted that, at least half of the first drug-carrying ellipsoid 21 is exposed outside the outer surface of the handle body 102 means that only a portion of the first drug-carrying ellipsoid 21 is located in the handle body 102, and most of the first drug-carrying ellipsoid 21 extends outside the outer surface of the handle body 102.
As shown in fig. 3 and 6, the slow release holes 25 are plural, and the slow release holes 25 are disposed at intervals on the first drug-carrying ellipsoid 21. In this way, the plurality of slow release holes 25 enable the anti-infective drug in the first drug-carrying ellipsoid 21 to release faster, so that the whole release period is shorter, which is beneficial to realizing anti-infective effect.
As shown in fig. 4 and 7, the mounting portion is a cavity with a segment, the medicine-carrying container 20 is a second medicine-carrying ellipsoid 22, and the second medicine-carrying ellipsoid 22 is connected with the cavity with a segment in an interference manner. Thus, at least half of the second drug-carrying ellipsoid 22 is sunk in the outer surface of the handle body 102, and when the bone-promoting drug is loaded in the accommodating cavity of the second drug-carrying ellipsoid 22, the bone-promoting drug in the second drug-carrying ellipsoid 22 acts on the fracture through the slow-release hole 25, so that the blood circulation around the fracture is good, faster osseointegration can be realized, and the osseointegration time can be shortened. Such bone-promoting agents include, but are not limited to, bisphosphonates, parathyroid hormone, fluoride, growth hormone. The outside diameter at the short axis of the second drug-loaded ellipsoid 22 described above is in the range of 1mm to 3 mm. When the anti-osteoporosis medicine is loaded in the accommodating cavity of the second medicine carrying ellipsoid 22, the anti-osteoporosis medicine in the second medicine carrying ellipsoid 22 acts on the osteoporosis part through the slow release holes 25, so that the peripheral blood circulation of the osteoporosis is good, and the osteoporosis can be treated quickly. The anti-osteoporosis agents described above include, but are not limited to, teriparatide, salmon calcitonin, raloxifene, zoledronic acid.
It should be noted that at least half of the second drug-carrying ellipsoid 22 is sunk into the outer surface of the handle body 102 means that the second drug-carrying ellipsoid 22 is entirely located in the handle body 102 or that a portion of the second drug-carrying ellipsoid 22 extends out of the outer surface of the handle body 102.
In the present embodiment, the plurality of mounting portions are arranged in multiple layers at intervals around the handle body 102, the plurality of medicine-carrying containers 20 are provided in one-to-one correspondence with the plurality of mounting portions, and the plurality of medicine-controlling chambers 11 are provided. When the handle body 102 is bent under the force F, the medicine control cavity 11 is compressed, and a plurality of medicine carrying containers 20 positioned on the same layer in the plurality of medicine carrying containers 20 are arranged in one-to-one correspondence with the plurality of medicine control cavities 11.
As shown in fig. 4 and 7, the flow-through hole 24 and the slow release hole 25 are each one. Thus, one of the overflow holes 24 and one of the slow release holes 25 enable the release speed of the bone-promoting drug in the second drug-carrying ellipsoid 22 to be slower, so that the whole release period is longer, and the bone-promoting effect is facilitated to be realized, so that faster osseointegration is realized.
The diameter of the accommodating cavity of the first medicine carrying ellipsoid 21 and the diameter of the accommodating cavity of the second medicine carrying ellipsoid 22 are both in the range of 0.3mm to 2.5 mm.
As shown in fig. 5 and 8, the mounting portion is a cylindrical cavity, the medicine-carrying container 20 is a medicine-carrying tube 23, the medicine-carrying tube 23 is connected to the cylindrical cavity in an interference manner, the overflow hole 24 is located at a first end of the cylindrical cavity, and the slow release hole 25 is located at a second end of the cylindrical cavity. Thus, at least half of the medicine carrying tube 23 is sunk in the outer surface of the handle body 102, when the anti-tumor medicine is loaded in the accommodating cavity of the medicine carrying tube 23, the medicine carrying tube 23 with a larger accommodating cavity can carry more medicine carrying amount, and the anti-tumor medicine in the medicine carrying tube 23 acts on the tumor through the slow release hole 25, so that the blood circulation around the tumor is good, and the tumor can be treated quickly. Such antineoplastic agents include, but are not limited to, alkylating agents and nitrogen mustards, platinum compounds, mitomycin, dihydrofolate reductase inhibitors, actinomycin D, paclitaxel, docetaxel.
It should be noted that at least a half of the drug-carrying tube 23 is sunk into the outer surface of the handle 102 means that the drug-carrying tube 23 is entirely located in the handle 102 or that a part of the drug-carrying tube 23 extends outside the outer surface of the handle 102.
As shown in fig. 5 and 8, the medicine carrying tube 23 has a polyhedral structure. Like this, the cylindricality chamber is the polyhedral structure too, and the medicine carrying pipe 23 of polyhedral structure can bear more medicine carrying amount, makes the sustained-release hole 25 great simultaneously to promote medicine carrying amount and the release rate of medicine carrying pipe 23, make whole release cycle shorter, be favorable to realizing anti-tumor effect. The above polyhedral structure is preferably honeycomb-shaped. The diameter of the inscribed circle of the honeycomb-shaped medicine-carrying tube 23 is in the range of 0.05mm to 0.5mm, and the height is in the range of 1mm to 3 mm.
As shown in fig. 3,4, 6 and 7, the diameter of the overflow hole 24 and the diameter of the slow release hole 25 are in the range of 100 micrometers to 800 micrometers, so that the slow release hole 25 can be used as a medicine slow release window of the medicine carrying container 20 to slowly release the anti-infective medicine or bone-promoting medicine or osteoporosis-treating medicine or anti-tumor medicine in the holding cavity of the medicine carrying container 20. In this way, the medicine carried by the medicine carrying container 20 on the handle body 102 is reasonably adjusted and matched in the operation, so that the selection of different medicines for resisting infection or promoting bone or treating osteoporosis or resisting tumor can be realized, and the selection of patients flexibly coping with fracture emergency can be realized.
As shown in fig. 1 to 5, when the receiving chamber of the medicine-carrying container 20 is loaded with the liquid medicine, both the outer surface of the handle body and the outer surface of the medicine-carrying container are covered with an overflow preventing layer in order to prevent the medicine from overflowing. The spill-resistant layer is preferably a biogel.
Of course, in embodiments not shown in the figures, the diameter of the overflow aperture or the diameter of the sustained release aperture may be in the range of 100 microns to 800 microns.
The handle body 102 of the present embodiment further includes a locking screw hole and a universal locking hole provided on the handle body 102, so that the femoral stem can be stably fixed in anatomy in cooperation with the anatomical form design.
As shown in fig. 9 to 12, the plurality of mounting portions are arranged in a plurality of layers at intervals around the handle 102, the plurality of medicine-carrying containers 20 are provided in one-to-one correspondence with the plurality of mounting portions, and the plurality of medicine-controlling chambers 11 are provided. When the handle 102 is bent under the force F, the medicine control chamber 11 is compressed, and a plurality of medicine carrying containers 20 positioned on the same layer among the plurality of medicine carrying containers 20 are arranged corresponding to one medicine control chamber 11. Thus, one drug control cavity 11 can simultaneously control the release amount of the drugs in the drug carrying containers 20 positioned on the same layer, so that the femoral stem can be provided with more drug carrying containers 20 while considering the internal structural stability of the femoral stem, and the drug carrying amount of the femoral stem is increased so as to realize fracture healing faster.
The phrase "a plurality of medicine containers 20 located on the same layer are disposed corresponding to one medicine control chamber 11" means that a plurality of medicine containers 20 having the same height in the horizontal direction or a height within an angle of 30 degrees from the horizontal direction are disposed corresponding to one medicine control chamber 11.
As shown in fig. 9 to 12, when a plurality of medicine carrying containers 20 positioned on the same layer of the plurality of medicine carrying containers 20 are arranged corresponding to one medicine control cavity 11, when the handle 102 is stressed and bent, the medicine control cavity 11 is compressed, since the number of cavity sections of each medicine control cavity 11 comprises two, the first cavity section comprises a first annular cambered surface 113 and a second annular cambered surface 114 opposite to the opening of the first annular cambered surface 113, an annular opening is formed between the first annular cambered surface 113 and the second annular cambered surface 114, the overflow holes 24 of the medicine carrying containers 20 positioned on the same layer of the plurality of medicine carrying containers 20 are positioned at the annular opening, and the medium in the medicine control cavity 11 is diffused all around and can flow out from the annular opening and enter the overflow holes 24 on the same layer, so that the medicine control cavity 11 can provide larger thrust to accelerate the release of medicine, and when the fracture is not healed or the patient moves more, the medicine release amount in the containing cavity is also larger, otherwise, the medicine release amount in the containing cavity is also smaller, and the medicine release condition in the containing cavity can be dynamically controlled according to the actual condition of the patient. In order to accurately and dynamically control the drug release according to the actual condition of the patient, the second cavity section comprises a first plane and a second plane which are arranged at intervals up and down, the first plane is connected to the inner side of the first annular cambered surface 113, and the second plane is connected to the inner side of the second annular cambered surface 114.
The shapes of the first annular cambered surface 113 and the second annular cambered surface 114 ensure that the medicine control cavity 11 has a certain supporting force, and the internal structure of the handle body 102 can be ensured to be stable when the medicine control cavity 11 is stressed and deformed. It should be noted that, the first annular cambered surface 113 and the second annular cambered surface 114 may be arch bridge-shaped or spherical segment-shaped.
As shown in fig. 2 and 13, the plurality of mounting portions are arranged in a plurality of layers at intervals around the handle body 102, the plurality of medicine-carrying containers 20 are provided in a plurality of one-to-one correspondence with the plurality of mounting portions, and the medicine-carrying containers 20 may be arranged on the upper half portion of the handle body 102 or may be arranged on the entire handle body 102. Both arrangements and others not shown in the figures may be adjusted to the condition of different patients.
The present application also provides a negative pressure drug delivery device for loading a plurality of drug delivery containers 20 of a femoral stem with a drug as shown in fig. 14. The negative pressure medicine loading device comprises a box body 51, a medicine loading box 60, a vacuum pump 30, a medicine push rod piece 40 and a box cover 52. The medicine-carrying box 60 is arranged in the box body 51, the femoral stem is arranged in the medicine-carrying box 60 in a removable mode, and the top of the medicine-carrying box 60 is provided with an opening. The vacuum pump 30 communicates with the interior cavity of the tank 51. The drug pusher member 40 is disposed within the housing 51 and communicates with the interior cavity of the drug cassette 60. The cover 52 is openably and closably provided at the opening of the case 51 to form a closed chamber with the case 51, thereby forming a sterile environment.
The medicine pushing rod 40 is filled with medicine, and the medicine pushing rod 40 pushes the medicine slowly into the medicine carrying box 60, so that the medicine in the accommodating cavity of the medicine carrying container 20 is loaded at one time under the action of the negative pressure suction force of the vacuum pump 30. Thus, different medicines can be loaded according to actual clinical requirements. Specifically, the drug is loaded by the vacuum pump 30, the handle 102 with the drug container 20 is placed in the drug cassette 60, the vacuum is pulled to 1×10-1 KPa, the valve of the drug pusher member 40 is opened, and the drug is sucked into the drug cassette 60. The negative pressure medicine carrying device can be put into an operating room for real-time operation, and the first medicine carrying ellipsoid 21, the second medicine carrying ellipsoid 22 or the medicine carrying tube 23 can be selected according to actual clinical requirements so as to carry corresponding kinds of medicines. When the negative pressure medicine loading is completed, the outer surface of the handle body 102 with the medicine loading container 20 is coated with biological gel to prevent the medicine in the medicine loading container 20 from overflowing.
As shown in fig. 14, in order to sterilize the sealed cavity at high temperature and high pressure, the negative pressure medicine-carrying device further includes a heating pipe 80 disposed in the box 51, so that the temperature in the sealed cavity can reach 118 ℃ to 124 ℃ and the pressure reaches 103KPa to 115KPa when the vacuum pump 30 is not operated, so that the handle 102 with the medicine-carrying container 20 can carry out efficient medicine carrying in a sterile environment.
In the description of the present invention, it should be understood that the azimuth or positional relationships indicated by the azimuth terms such as "front, rear, upper, lower, left, right", "lateral, vertical, horizontal", and "top, bottom", etc., are generally based on the azimuth or positional relationships shown in the drawings, and are merely for convenience of describing the present invention and simplifying the description, and these azimuth terms do not indicate and imply that the apparatus or elements referred to must have a specific azimuth or be constructed and operated in a specific azimuth, and thus should not be construed as limiting the scope of the present invention, and the azimuth terms "inside and outside" refer to inside and outside with respect to the outline of each component itself.
Spatially relative terms, such as "above," "upper" and "upper surface," "above" and the like, may be used herein for ease of description to describe one device or feature's spatial relationship to another device or feature as illustrated in the figures. It will be understood that the spatially relative terms are intended to encompass different orientations in use or operation in addition to the orientation depicted in the figures. For example, if the device in the figures is turned over, elements described as "above" or "over" other devices or structures would then be oriented "below" or "beneath" the other devices or structures. Thus, the process is carried out, the exemplary term "above" may be included. Upper and lower. Two orientations below. The device may also be positioned in other different ways (rotated 90 degrees or at other orientations) and the spatially relative descriptors used herein interpreted accordingly.
In addition, the terms "first", "second", etc. are used to define the components, and are only for convenience of distinguishing the corresponding components, and the terms have no special meaning unless otherwise stated, and therefore should not be construed as limiting the scope of the present invention.
The above description is only of the preferred embodiments of the present invention and is not intended to limit the present invention, but various modifications and variations can be made to the present invention by those skilled in the art. Any modification, equivalent replacement, improvement, etc. made within the spirit and principle of the present invention should be included in the protection scope of the present invention.