CN114681583A - Composition for clearing heat from throat, benefiting lung and stopping smoking as well as preparation method and application thereof - Google Patents

Abstract

Translated fromChinese

本发明涉及戒烟产品技术领域，具体涉及一种清咽利肺戒烟组合物及其制备方法和应用。该清咽利肺戒烟组合物由黄连、竹茹、紫菀、百部、瓜蒌、半夏、桔梗、白前、陈皮、橘红等原料制成，具有清热利肺、理气化痰、和胃利胆、燥湿、解郁的功效，能够通过吸入的方式而改善抽烟导致的苦口、咽干、咽痒、咳嗽、咯痰不爽、肺部干燥、舌苔黄腻等烟民常见症状，并能缓解烟瘾，在长期吸烟者对香烟产品难以割舍时产生安抚作用，戒烟过程温和且无副作用。该清咽利肺戒烟组合物中不含尼古丁或其他成瘾成分，不会因长期使用而产生依赖，可用于制成清咽利肺戒烟电子烟。

The invention relates to the technical field of smoking cessation products, in particular to a composition for clearing the throat, improving the lungs and quitting smoking, and a preparation method and application thereof. The composition for clearing throat and improving lungs for smoking cessation is prepared from raw materials such as Coptis chinensis, Zhuru, Aster, Baibu, Gualou, Pinellia, Platycodon grandiflorum, Baiqian, dried tangerine peel, orange red, etc. The effects of gallbladder, dampness, and depression can be improved by inhalation to improve the common symptoms of smokers such as bitterness, dry throat, itchy throat, cough, unpleasant expectoration, dry lungs, yellow and greasy tongue coating, etc. Tobacco addiction has a soothing effect when long-term smokers are difficult to give up cigarette products, and the smoking cessation process is mild and has no side effects. The composition for clearing the throat and improving the lungs for smoking cessation does not contain nicotine or other addictive components, and will not cause dependence due to long-term use, and can be used to prepare an electronic cigarette for clearing the throat and improving the lungs and smoking cessation.

Description

Translated fromChinese

一种清咽利肺戒烟组合物及其制备方法和应用A kind of composition for clearing throat and improving lungs and quitting smoking, preparation method and application thereof

技术领域technical field

本发明涉及戒烟产品技术领域，具体涉及一种清咽利肺戒烟组合物及其制备方法和应用。The invention relates to the technical field of smoking cessation products, in particular to a composition for clearing the throat, improving the lungs and smoking cessation, and a preparation method and application thereof.

背景技术Background technique

烟草燃烧可以产生含7000多种物质的烟雾，而且大多数对人体有害。吸烟时烟雾从口中进入，经喉、气管、支气管进入血液，长期吸烟很容易引发喉头炎、气管炎，肺气肿等多种疾病，极度危害身体健康且具有成瘾性。约80％的吸烟者希望能够戒烟，但往往因难以克服烟瘾而无法成功戒烟。Tobacco burning can produce smoke containing more than 7,000 substances, most of which are harmful to humans. When smoking, smoke enters from the mouth and enters the blood through the larynx, trachea, and bronchi. Long-term smoking can easily lead to various diseases such as laryngitis, bronchitis, and emphysema, which is extremely harmful to health and is addictive. About 80% of smokers want to be able to quit, but are often unable to successfully quit because of the difficulty in overcoming their cravings.

目前市场中戒烟贴、戒烟喷雾都需直接接触皮肤，易产生皮肤过敏反应，而戒烟贴和戒烟喷雾中的化学成分还有可能对神经系统造成危害。近年来电子烟系列产品愈发流行，可人为降低烟油中尼古丁、烟碱等物质以减少危害，但是仍存在多种不确定因素，部分实验表明，人们在使用电子烟时，除尼古丁以外，还会把多种有毒化合物吸入体内，并不能实现人体零伤害。At present, smoking cessation stickers and smoking cessation sprays in the market need to be in direct contact with the skin, which is prone to skin allergic reactions, and the chemical components in smoking cessation stickers and smoking cessation sprays may also cause harm to the nervous system. In recent years, e-cigarette series products have become more and more popular, and nicotine, nicotine and other substances in e-liquid can be artificially reduced to reduce harm, but there are still many uncertain factors. Some experiments show that when people use e-cigarettes, in addition to nicotine, It will also inhale a variety of toxic compounds into the body, which cannot achieve zero harm to the human body.

发明内容SUMMARY OF THE INVENTION

针对吸烟者难以克服烟瘾，尼古丁等成分会对人体产生危害等技术问题，本发明提供一种清咽利肺戒烟组合物及其制备方法和应用。该清咽利肺戒烟组合物能够缓解烟瘾，从而有助于其戒烟，同时，该清咽利肺戒烟组合物还能够减少缓解抽烟导致的苦口、咽痒、咳嗽咽痒、咯痰不爽等症状。Aiming at the technical problems that it is difficult for smokers to overcome the craving for smoking, and nicotine and other components will cause harm to the human body, the present invention provides a composition for clearing the throat, invigorating the lungs, and quitting smoking, and a preparation method and application thereof. The throat clearing, lung and smoking cessation composition can relieve smoking addiction, thereby helping the smoking cessation. Meanwhile, the throat clearing, lung and smoking cessation composition can also reduce and relieve symptoms such as bitter mouth, itchy throat, itchy throat, and unpleasant expectoration caused by smoking. .

为达到上述发明目的，本发明实施例采用了如下的技术方案：In order to achieve the above-mentioned purpose of the invention, the embodiment of the present invention adopts the following technical scheme:

第一方面，本发明实施例提供一种清咽利肺戒烟组合物，由包括以下重量份数配比的中药原料制成：黄连8～12份、竹茹15～25份、枳实8～12份、半夏8～12份、橘红8～12份、甘草5～7份、生姜5～7份、茯苓8～12份、桔梗8～12份、紫菀8～12份、百部15～25份、白前8～12份、陈皮8～12份、艾叶8～12份、紫苏叶8～12份、薄荷8～12份、冰片2～4份和瓜蒌10～20份。In the first aspect, the embodiments of the present invention provide a composition for clearing the throat, invigorating the lungs and quitting smoking, which is prepared from the following traditional Chinese medicine raw materials in parts by weight: 8-12 parts of Coptis chinensis, 15-25 parts of Zhuru, and 8-25 parts of Citrus aurantium. 12 servings, Pinellia 8-12 servings, Orange red 8-12 servings, Licorice 5-7 servings, Ginger 5-7 servings, Poria 8-12 servings, Platycodon 8-12 servings, Aster 8-12 servings, Bai Bu 15- serving 25 parts, 8-12 parts of Baiqian, 8-12 parts of dried tangerine peel, 8-12 parts of mugwort leaves, 8-12 parts of perilla leaves, 8-12 parts of mint, 2-4 parts of borneol and 10-20 parts of melon.

该清咽利肺戒烟组合物由上述中药原料在以上配比下制得，各味中药的配伍关系如下：The composition for clearing the throat, improving the lungs and quitting smoking is prepared from the above-mentioned traditional Chinese medicine raw materials in the above proportions, and the compatibility relationship of each traditional Chinese medicine is as follows:

黄连和胃止泻、泻火解毒、抗菌杀毒；竹茹清胆和胃，止呕除烦；紫菀、百部味甘苦而性温，功擅化痰止咳，新久咳嗽皆宜；瓜蒌性微寒，清热涤痰、宽胸散结。以上五味中药在该组合物中为君药。Coptis and stomach to stop diarrhea, purging fire and detoxification, antibacterial and killing poison; Bamboo Ru clearing gallbladder and stomach, relieving vomiting and eliminating vexation; Aster and Baibu are sweet and bitter in taste and warm in nature, good at resolving phlegm and relieving cough, suitable for Xinjiu cough; Slightly cold, clearing away heat and phlegm, widening the chest and dispelling knots. The above five traditional Chinese medicines are monarch medicines in the composition.

半夏燥湿化痰，降逆止呕；枳实理气化痰，使气顺则痰消；桔梗、白前宣降肺气，化痰止咳，引药上行；陈皮理气化痰；橘红理气宽中，燥湿化痰。以上六味中药在该组合物中为臣药。Pinellia dries dampness and resolves phlegm, lowers phlegm and relieves vomiting; Citrus aurantium regulates qi and resolves phlegm, so that qi is smooth and phlegm is eliminated; Platycodon grandiflorum and Baiqian disperse lung qi, resolve phlegm and relieve cough, and induce medicine to ascend; Chenpi regulates qi and resolves phlegm; orange red regulates qi widening In the middle, dry dampness and resolve phlegm. The above six traditional Chinese medicines are subject medicines in the composition.

冰片开窍醒神、清热散毒、消肿止痛；紫苏叶行气和胃、理气、解瘀泄毒；茯苓健脾渗湿，以杜生痰之源；薄荷清利头目、利咽止痛；艾叶控制情绪，减轻焦虑，增强人体对疾病的抵抗能力，同时具有很好的抗氧化作用。以上五味中药在该组合物中为佐药。Borneol rejuvenates the mind, clears heat and dissipates toxins, reduces swelling and relieves pain; perilla leaves invigorates the stomach, regulates qi, relieves blood stasis and detoxifies; Poria invigorates the spleen and infiltrates dampness, which is the source of eliminating phlegm; peppermint clears the head, relieves the sore throat and relieves pain; Artemisia argyi controls emotions, relieves anxiety, enhances the body's resistance to disease, and has a good antioxidant effect. The above five traditional Chinese medicines are adjuvants in the composition.

甘草益脾和中，调和诸药，在该组合物中为使药。Licorice can benefit the spleen and neutralize the middle, reconcile various medicines, and is the main medicine in the composition.

该清咽利肺戒烟组合物通过以上中药的合理配伍，具有清热利肺、理气化痰、和胃利胆、燥湿、解郁的功效，能够通过吸入的方式而改善抽烟导致的苦口、咽干、咽痒、咳嗽、咯痰不爽、肺部干燥、舌苔黄腻等烟民常见症状，并能缓解烟瘾，在长期吸烟者对香烟产品难以割舍时产生安抚作用，戒烟过程温和且无副作用。同时，相关实验还证明本产品药方对于治鼻炎和咽炎等呼吸系统疾病也有一定的防治功效，并可增强免疫力，有利于提高戒烟者的健康水平。Through the rational compatibility of the above traditional Chinese medicines, the composition for clearing the throat and promoting the lungs and smoking cessation has the functions of clearing heat and improving the lungs, regulating qi and resolving phlegm, relieving the stomach and gallbladder, drying dampness and relieving depression, and can improve the bitterness and throat caused by smoking through inhalation. Dry, itchy throat, cough, unpleasant phlegm, dry lungs, yellow and greasy tongue coating and other common symptoms of smokers, and can relieve smoking addiction, and have a soothing effect when long-term smokers are difficult to give up cigarette products. At the same time, relevant experiments have also proved that this product's prescription also has certain preventive and therapeutic effects on respiratory diseases such as rhinitis and pharyngitis, and can enhance immunity, which is beneficial to improve the health of quitters.

该清咽利肺戒烟组合物中不含尼古丁或其他成瘾成分，不会因长期使用而产生依赖。The composition for clearing the throat and promoting the lungs and smoking cessation does not contain nicotine or other addictive components, and will not cause dependence due to long-term use.

优选地，所述清咽利肺戒烟组合物由包括以下重量份数配比的中药原料制成：黄连9～11份、竹茹18～22份、枳实9～11份、半夏9～11份、橘红9～11份、甘草5.5～6.5份、生姜5.5～6.5份、茯苓9～11份、桔梗9～11份、紫菀9～11份、百部18～22份、白前9～11份、陈皮9～11份、艾叶9～11份、紫苏叶9～11份、薄荷9～11份、冰片2.5～3.5份和瓜蒌13～17份。Preferably, the composition for clearing the throat, improving the lungs and quitting smoking is made from the following traditional Chinese medicine raw materials in parts by weight: 9-11 parts of Coptis chinensis, 18-22 parts of Zhuru, 9-11 parts of Citrus aurantium, 9-11 parts of Pinellia chinensis 11 parts, 9-11 parts of orange, 5.5-6.5 parts of licorice, 5.5-6.5 parts of ginger, 9-11 parts of Poria, 9-11 parts of Campanulaceae, 9-11 parts of aster, 18-22 parts of Baibu, 9-11 parts of Baiqian 11 parts, 9-11 parts of dried tangerine peel, 9-11 parts of mugwort leaves, 9-11 parts of perilla leaves, 9-11 parts of mint, 2.5-3.5 parts of borneol and 13-17 parts of melon.

优选地，所述清咽利肺戒烟组合物由包括以下重量份数配比的中药原料制成：黄连10份、竹茹20份、枳实10份、半夏10份、橘红10份、甘草6份、生姜6份、茯苓10份、桔梗10份、紫菀10份、百部20份、白前10份、陈皮10份、艾叶10份、紫苏叶10份、薄荷10份、冰片3份和瓜蒌15份。Preferably, the composition for clearing the throat and improving the lungs and smoking cessation is made from the following traditional Chinese medicine raw materials in parts by weight: 10 parts of Coptis chinensis, 20 parts of Bamboo Ru, 10 parts of Citrus aurantium, 10 parts of Pinellia, 10 parts of orange red, licorice root 6 parts, 6 parts ginger, 10 parts Poria, 10 parts Campanulaceae, 10 parts aster, 20 parts Baibu, 10 parts Baiqian, 10 parts tangerine peel, 10 parts wormwood leaves, 10 parts perilla leaves, 10 parts mint, 3 parts borneol And 15 servings of Gualou.

在上述优选的配比下，该清咽利肺戒烟组合物能够产生更好的清咽利肺、降低烟瘾的作用。Under the above-mentioned preferred ratio, the composition for clearing the throat and improving the lungs and smoking cessation can produce better effects of clearing the throat and improving the lungs and reducing smoking addiction.

优选地，制成所述清咽利肺戒烟组合物的所述中药原料还包括黄芩8～13份。加入黄芩后，该组合物还具有清上焦火热、宽胸散结的功效，能够进一步缓解烟瘾并消除长期抽烟所带来的咳嗽等症状，还有助于消除长期抽烟所带来的胸闷。Preferably, the raw materials of the traditional Chinese medicine for preparing the composition for clearing the throat and improving the lungs and smoking cessation further include 8-13 parts of Scutellaria baicalensis. After adding Scutellaria baicalensis, the composition also has the effects of clearing scorched burns, widening the chest and dispelling knots, further relieving smoking addiction, eliminating symptoms such as cough caused by long-term smoking, and also helping to eliminate chest tightness caused by long-term smoking.

优选地，所述黄芩的重量份数为9～11份，进一步优选为10份。Preferably, the weight part of the skullcap is 9 to 11 parts, more preferably 10 parts.

第二方面，本发明实施例还提供了上述清咽利肺戒烟组合物的制备方法，包括以下操作：提取除冰片外其余所述中药原料的精油，按上述清咽利肺戒烟组合物中的各原料的重量份数配比将各精油混合均匀，加入所述冰片并溶解，即得所述清咽利肺戒烟组合物。即，该清咽利肺戒烟组合物中各精油以及冰片的质量配比以其对应的中药原料的质量计。In the second aspect, an embodiment of the present invention also provides a method for preparing the above-mentioned composition for clearing the throat, improving the lungs, and quitting smoking, including the following operations: extracting the essential oils of the traditional Chinese medicine raw materials except borneol, The proportion by weight of each raw material is mixed evenly with each essential oil, and the borneol is added and dissolved to obtain the composition for clearing the throat, improving the lungs and quitting smoking. That is, the mass ratio of each essential oil and borneol in the composition for clearing the throat and improving the lungs and smoking cessation is calculated based on the mass of the corresponding traditional Chinese medicine raw materials.

该制备方法还可选用以下操作：按重量份数配比称取各原料，提取除冰片外其余所述中药原料的精油，将所得精油混合均匀，加入所述冰片并溶解，即得所述清咽利肺戒烟组合物。The preparation method can also choose the following operations: weighing each raw material in proportion by weight, extracting the essential oils of the other Chinese medicine raw materials except borneol, mixing the obtained essential oils evenly, adding the borneol and dissolving to obtain the clear Pharyngeal Lung Smoking Cessation Composition.

上述两种制备方法在实际应用中可根据生产条件进行选择。此处应理解，与上述制备方法无实质区别的其他操作方式也在本发明保护范围之内。The above two preparation methods can be selected according to the production conditions in practical application. It should be understood here that other operation modes that are not substantially different from the above-mentioned preparation method also fall within the protection scope of the present invention.

以上各原料的精油可购自市售精油，也可采用以下方法制得：将所述中药原料加3～7倍量纯净水蒸馏提取3～5小时，收集所得油状成分，即得。市售精油或按该方法制得的精油均可用于制成该清咽利肺戒烟组合物，并能产生相似功效。The essential oils of the above raw materials can be purchased from commercially available essential oils, and can also be prepared by the following method: adding 3 to 7 times the amount of pure water to the Chinese medicine raw materials and extracting by distillation for 3 to 5 hours, and collecting the obtained oily components to obtain the final product. Commercially available essential oils or essential oils prepared by this method can be used to prepare the composition for clearing the throat, improving the lungs and smoking cessation, and can produce similar effects.

第三方面，本发明实施例还提供了上述清咽利肺戒烟组合物在制备清咽利肺戒烟电子烟中的应用。In a third aspect, the embodiments of the present invention also provide the application of the above-mentioned composition for clearing the throat, promoting the lungs, and quitting smoking in the preparation of electronic cigarettes for clearing the throat, promoting the lungs, and quitting smoking.

电子烟是一种非燃烧型的电子雾化设备，采用微电子技术和物理雾化技术，把烟油雾化成烟雾状，人性化模拟出吸烟过程。Electronic cigarette is a non-combustible electronic atomization device. It uses microelectronic technology and physical atomization technology to atomize the e-liquid into smoke, and humanizedly simulate the smoking process.

本发明将上述清咽利肺戒烟组合物制成清咽利肺戒烟电子烟后，一方面，通过微电子技术和物理雾化技术，把中药精油雾化成烟雾状，通过吸入的方式产生清咽、利肺、降低烟瘾的作用；另一方面，电子烟的外形与香烟相似，能够减少戒烟者、特别是长期吸烟的戒烟者对产品的芥蒂排斥心理，缓解无香烟时的焦虑心理，减少了戒烟的困难。另外，电子烟方便携带和使用，不受时间空间的限制，更易于被接受。In the present invention, after the above-mentioned composition for clearing the throat, improving the lungs, and quitting smoking is made into an electronic cigarette for clearing the throat, improving the lungs, and quitting smoking, on the one hand, the essential oil of traditional Chinese medicine is atomized into a smoke shape through the microelectronic technology and the physical atomization technology, and the throat clearing is produced by inhalation. On the other hand, the appearance of electronic cigarettes is similar to that of cigarettes, which can reduce the rejection of products by smokers, especially long-term smokers, relieve anxiety when there is no cigarette, and reduce the Difficulty quitting smoking. In addition, electronic cigarettes are easy to carry and use, are not limited by time and space, and are more easily accepted.

优选地，所述清咽利肺戒烟电子烟设有烟油存储腔，所述清咽利肺戒烟组合物置于烟油存储腔中。Preferably, the e-cigarette for clearing the throat and improving the lungs and smoking cessation is provided with an e-liquid storage cavity, and the composition for clearing the throat and improving the lungs and smoking cessation is placed in the e-liquid storage cavity.

本发明对清咽利肺戒烟电子烟的构造不做限定，市售的含有烟油存储腔的电子烟均可用于制备该清咽利肺戒烟电子烟，将该清咽利肺戒烟组合物，置于烟油存储腔中代替常规烟油即可。The present invention does not limit the structure of the electronic cigarette for clearing the throat, improving the lungs, and quitting smoking. Commercially available electronic cigarettes containing an e-liquid storage cavity can be used to prepare the electronic cigarette for clearing the throat, improving the lungs, and quitting smoking. It can be placed in the e-liquid storage cavity instead of conventional e-liquid.

附图说明Description of drawings

图1为本发明实施例11中清咽利肺戒烟电子烟的剖面示意图；1 is a schematic cross-sectional view of an electronic cigarette for clearing the throat, improving the lungs, and quitting smoking in Example 11 of the present invention;

图2为本发明实施例11中清咽利肺戒烟电子烟的立体示意图；FIG. 2 is a three-dimensional schematic diagram of an electronic cigarette for clearing the throat, improving the lungs, and quitting smoking in Embodiment 11 of the present invention;

图3为本发明试验例1中的实验装置。FIG. 3 is the experimental device in Test Example 1 of the present invention.

具体实施方式Detailed ways

为了使本发明的目的、技术方案及优点更加清楚明白，以下结合具体实施例，对本发明进行进一步详细说明。应当理解，此处所描述的具体实施例仅仅用以解释本发明，并不用于限定本发明。In order to make the objectives, technical solutions and advantages of the present invention clearer, the present invention will be further described in detail below with reference to specific embodiments. It should be understood that the specific embodiments described herein are only used to explain the present invention, but not to limit the present invention.

长期吸烟者在停吸或减少吸食香烟时会产生渴望吸烟、烦躁、忧郁、头痛、不安定、精神难以集中、昏昏欲睡、肠胃功能失调等多种身体及心理的综合反应，中医临床症状包括舌苔黄腻、脉弦滑、脘痞胸闷、恶心、眩晕以及神经衰弱等。对此，本发明以中草药为药效成分进行了研究，得到由包括以下重量份数配比的原料制成的清咽利肺戒烟组合物：黄连8～12份、竹茹15～25份、枳实8～12份、半夏8～12份、橘红8～12份、甘草5～7份、生姜5～7份、茯苓8～12份、桔梗8～12份、紫菀8～12份、百部15～25份、白前8～12份、陈皮8～12份、艾叶8～12份、紫苏叶8～12份、薄荷8～12份、冰片2～4份和瓜蒌10～20份。Long-term smokers will have a variety of physical and psychological comprehensive reactions such as craving for smoking, irritability, depression, headache, restlessness, difficulty concentrating, drowsiness, and gastrointestinal dysfunction when they stop smoking or reduce cigarette smoking. TCM clinical symptoms Including yellow and greasy tongue coating, slippery pulse, epigastric chest tightness, nausea, dizziness and neurasthenia. In this regard, the present invention uses Chinese herbal medicines as medicinal components to conduct research, and obtains a throat-clearing, lung-reducing and smoking-cessation composition prepared from the following raw materials in parts by weight: 8-12 parts of Coptis chinensis, 15-25 parts of Zhuru, 8-12 parts of Citrus, 8-12 parts of Pinellia, 8-12 parts of Orange, 5-7 parts of Licorice, 5-7 parts of Ginger, 8-12 parts of Poria, 8-12 parts of Campanulaceae, 8-12 parts of Aster, 15-25 parts of Baibu, 8-12 parts of Baiqian, 8-12 parts of dried tangerine peel, 8-12 parts of mugwort leaves, 8-12 parts of perilla leaves, 8-12 parts of mint, 2-4 parts of borneol and 10-10 parts of melon 20 servings.

该清咽利肺戒烟组合物通过上述原料在特定用量配比下的配伍，具有清热利肺、理气化痰、和胃、解郁的功效。The throat-clearing and lung-clearing composition for smoking cessation has the effects of clearing heat and improving lung, regulating qi and resolving phlegm, relieving stomach and relieving depression through the compatibility of the above-mentioned raw materials in a specific dosage ratio.

该清咽利肺戒烟组合物的制备方法，包括以下操作：提取除冰片外其余所述中药原料的精油，按上述清咽利肺戒烟组合物中的各原料的重量份数配比将各精油混合均匀，加入所述冰片并溶解，即得，或，按重量份数配比称取各原料，提取除冰片外其余所述中药原料的精油，将所得精油混合均匀，加入所述冰片并溶解，即得。The preparation method of the composition for clearing the throat, improving the lungs and quitting smoking, comprises the following operations: extracting the essential oils of the other traditional Chinese medicine raw materials except borneol; Mix homogeneously, add the borneol and dissolve, that is, to obtain, or, weigh each raw material according to the proportion by weight, extract the essential oils of the remaining Chinese medicine raw materials except borneol, mix the obtained essential oils, add the borneol and dissolve , that is.

该清咽利肺戒烟组合物可用于制备清咽利肺戒烟电子烟，通过电子烟的微电子技术和物理雾化技术，以上中药原料的精油能够被雾化成烟雾状而通过吸入的方式来产生清咽、利肺、降低烟瘾的作用，同时，电子烟的外形能够减少戒烟者对产品的芥蒂排斥心理，缓解无香烟的焦虑心理，减少了戒烟的困难。并且电子烟方便携带和使用，易于被接受。The composition for clearing throat and improving lungs and smoking cessation can be used to prepare electronic cigarettes for clearing throat, improving lungs and quitting smoking. Through the microelectronic technology and physical atomization technology of electronic cigarettes, the essential oils of the above traditional Chinese medicine raw materials can be atomized into smoke and produced by inhalation. At the same time, the shape of the electronic cigarette can reduce the reluctance of quitters to the product, relieve the anxiety of no cigarette, and reduce the difficulty of quitting smoking. And electronic cigarettes are easy to carry and use, and are easy to be accepted.

市售的含有烟油存储腔的电子烟均可用于制备该清咽利肺戒烟电子烟，以该清咽利肺戒烟组合物代替烟油即可。Commercially available electronic cigarettes containing e-liquid storage cavity can be used to prepare the electronic cigarette for clearing the throat and improving the lungs and smoking cessation.

下面分多个实施例对本发明实施例进行进一步的说明。The embodiments of the present invention will be further described below by dividing into multiple embodiments.

以下实施例中所采用的实验方法如无特殊说明，均为本领域的常规方法。The experimental methods adopted in the following examples are conventional methods in the art unless otherwise specified.

以下实施例中所使用的黄连、竹茹、枳实、半夏、橘红、甘草、生姜、茯苓、桔梗、紫菀、百部、白前、陈皮、艾叶、紫苏叶、薄荷、冰片、瓜蒌和黄芩均符合《中国药典》(2020年版)一部正文各药材项下的有关规定。Coptis chinensis, Bamboo Ru, Citrus aurantium, Pinellia, Orange, Licorice, Ginger, Poria, Platycodon grandiflorum, Aster, Baibu, Baiqian, dried tangerine peel, Artemisia argyi, Perilla leaves, Mint, Borneol, Gualou used in the following examples Both Scutellaria and Scutellaria complied with the relevant regulations under each medicinal material in the first text of the Chinese Pharmacopoeia (2020 Edition).

以下实施例中所采用的其他原料、试剂等，如无特殊说明，均从商业途径获得。Other raw materials, reagents, etc. used in the following examples are obtained from commercial sources unless otherwise specified.

实施例1Example 1

本发明实施例提供了一种清咽利肺戒烟组合物，由以下重量份数配比的中药原料制成：黄连10份、竹茹20份、枳实10份、半夏10份、橘红10份、甘草6份、生姜6份、茯苓10份、桔梗10份、紫菀10份、百部20份、白前10份、陈皮10份、艾叶10份、紫苏叶10份、薄荷10份、冰片3份和瓜蒌15份。The embodiment of the present invention provides a composition for clearing the throat, improving the lungs, and quitting smoking, which is prepared from the following traditional Chinese medicine raw materials in parts by weight: 10 parts of Coptis chinensis, 20 parts of Zhuru, 10 parts of Citrus aurantium, 10 parts of Pinellia sinensis, 10 parts of orange red parts, 6 parts of licorice, 6 parts of ginger, 10 parts of Poria, 10 parts of Platycodon grandiflorum, 10 parts of Aster, 20 parts of Bai Bu, 10 parts of Bai Qian, 10 parts of dried tangerine peel, 10 parts of Artemisia argyi, 10 parts of Perilla leaves, 10 parts of Mint, 3 parts of borneol and 15 parts of melon.

该清咽利肺戒烟组合物的制备方法为：The preparation method of the composition for clearing the throat and promoting the lungs and quitting smoking is as follows:

按重量份数配比称取各原料；Weigh each raw material according to the proportion by weight;

将黄连加4倍量纯净水蒸馏提取4小时，收集所得油状成分，得黄连精油；Coptis chinensis was added with 4 times of purified water and extracted by distillation for 4 hours, and the gained oily components were collected to obtain Coptis chinensis essential oil;

将竹茹加6倍量纯净水蒸馏提取4小时，收集所得油状成分，得竹茹精油；Add 6 times the amount of pure water to distilling and extracting bamboo ru for 4 hours, collect gained oily component, obtain zhu ru essential oil;

将枳实加4倍量纯净水蒸馏提取5小时，收集所得油状成分，得枳实精油；Fructus Fructus was added with 4 times of purified water and extracted by distillation for 5 hours, and the gained oily component was collected to obtain Fructus Citrus essential oil;

将半夏加4倍量纯净水蒸馏提取5小时，收集所得油状成分，得半夏精油；Distillation and extraction of Pinellia 4 times of purified water was carried out for 5 hours, and the gained oily components were collected to obtain Pinellia essential oil;

将橘红加4倍量纯净水蒸馏提取5小时，收集所得油状成分，得橘红精油；The orange red is added with 4 times of purified water and extracted by distillation for 5 hours, and the gained oily component is collected to obtain the orange red essential oil;

将甘草加6倍量纯净水蒸馏提取3小时，收集所得油状成分，得甘草精油；The licorice root was added with 6 times of purified water and extracted by distillation for 3 hours, and the gained oily component was collected to obtain the licorice essential oil;

将生姜加3倍量纯净水蒸馏提取4小时，收集所得油状成分，得生姜精油；Ginger was added with 3 times of purified water and extracted by distillation for 4 hours, and the gained oily component was collected to obtain ginger essential oil;

将茯苓加5倍量纯净水蒸馏提取5小时，收集所得油状成分，得茯苓精油；Poria cocos is added with 5 times of purified water for distillation and extraction for 5 hours, and the gained oily components are collected to obtain the Poria essential oil;

将桔梗加5倍量纯净水蒸馏提取3小时，收集所得油状成分，得桔梗精油；Platycodon grandiflorum was added with 5 times of purified water and extracted by distillation for 3 hours, and the gained oily component was collected to obtain Platycodon grandiflorum essential oil;

将紫菀加6倍量纯净水蒸馏提取3小时，收集所得油状成分，得紫菀精油；Aster was added with 6 times of purified water and extracted by distillation for 3 hours, and the gained oily component was collected to obtain Aster essential oil;

将百部加5倍量纯净水蒸馏提取4小时，收集所得油状成分，得百部精油；Add 5 times the amount of purified water to 100 parts by distillation and extract for 4 hours, collect the gained oily components, and obtain 100 parts essential oil;

将白前加5倍量纯净水蒸馏提取4小时，收集所得油状成分，得白前精油；Add 5 times the amount of purified water to extract by distillation for 4 hours, and collect the gained oily components to obtain the essential oil of Baiqian;

将陈皮加5倍量纯净水蒸馏提取3小时，收集所得油状成分，得陈皮精油；The tangerine peel was added with 5 times of purified water and extracted by distillation for 3 hours, and the gained oily component was collected to obtain the tangerine peel essential oil;

将艾叶加6倍量纯净水蒸馏提取3小时，收集所得油状成分，得艾叶精油；Add 6 times the amount of purified water to distilling and extracting wormwood leaves for 3 hours, collect the gained oily components, and obtain wormwood leaf essential oil;

将紫苏叶加6倍量纯净水蒸馏提取3小时，收集所得油状成分，得紫苏叶精油；The basil leaves were added with 6 times of purified water for distillation and extraction for 3 hours, and the gained oily components were collected to obtain the basil leaves essential oil;

将薄荷加4倍量纯净水蒸馏提取3小时，收集所得油状成分，得薄荷精油；Peppermint was added with 4 times of purified water and extracted by distillation for 3 hours, and the gained oily component was collected to obtain peppermint essential oil;

将瓜蒌加7倍量纯净水蒸馏提取5小时，收集所得油状成分，得瓜蒌精油；Add 7 times of the amount of Fructus Fructus Fructus by distillation and extract for 5 hours, and collect the gained oily components to obtain Fructus Fructus Fructus essential oil;

将所得精油混合均匀，加入所述冰片并溶解，即得该清咽利肺戒烟组合物。The obtained essential oil is mixed evenly, and the borneol is added and dissolved to obtain the composition for clearing the throat, improving the lungs, and quitting smoking.

实施例2Example 2

本发明实施例提供了一种清咽利肺戒烟组合物，由以下重量份数配比的中药原料制成：黄连9份、竹茹18份、枳实9份、半夏9份、橘红9份、甘草5.5份、生姜5.5份、茯苓9份、桔梗9份、紫菀9份、百部18份、白前9～11份、陈皮9份、艾叶9份、紫苏叶9份、薄荷9份、冰片2.5份和瓜蒌13份。The embodiment of the present invention provides a composition for clearing the throat, improving the lungs and quitting smoking, which is prepared from the following traditional Chinese medicine raw materials in parts by weight: 9 parts of Coptis chinensis, 18 parts of Zhuru, 9 parts of Citrus aurantium, 9 parts of Pinellia sinensis, 9 parts of orange red parts, 5.5 parts of licorice, 5.5 parts of ginger, 9 parts of Poria, 9 parts of Campanulaceae, 9 parts of Aster, 18 parts of Bai Bu, 9 to 11 parts of Bai Qian, 9 parts of dried tangerine peel, 9 parts of Artemisia argyi, 9 parts of Perilla leaves, 9 parts of Mint servings, 2.5 servings of borneol and 13 servings of Gualou.

该清咽利肺戒烟组合物的制备方法同实施例1。The preparation method of the composition for clearing the throat and improving the lungs and smoking cessation is the same as that in Example 1.

实施例3Example 3

本发明实施例提供了一种清咽利肺戒烟组合物，由以下重量份数配比的中药原料制成：黄连11份、竹茹22份、枳实11份、半夏11份、橘红11份、甘草6.5份、生姜6.5份、茯苓11份、桔梗11份、紫菀11份、百部22份、白前11份、陈皮11份、艾叶11份、紫苏叶11份、薄荷11份、冰片3.5份和瓜蒌17份。The embodiment of the present invention provides a composition for clearing the throat, invigorating the lungs and quitting smoking, which is prepared from the following traditional Chinese medicine raw materials in parts by weight: 11 parts of Coptis chinensis, 22 parts of Bamboo Ru, 11 parts of Citrus aurantium, 11 parts of Pinellia sinensis, 11 parts of orange red parts, 6.5 parts of licorice, 6.5 parts of ginger, 11 parts of Poria, 11 parts of Campanulaceae, 11 parts of aster, 22 parts of Baibu, 11 parts of Baiqian, 11 parts of dried tangerine peel, 11 parts of Artemisia argyi, 11 parts of perilla leaves, 11 parts of mint, 3.5 parts of borneol and 17 parts of melon.

该清咽利肺戒烟组合物的制备方法同实施例1。The preparation method of the composition for clearing the throat and improving the lungs and smoking cessation is the same as that in Example 1.

实施例4Example 4

本发明实施例提供了一种清咽利肺戒烟组合物，由以下重量份数配比的中药原料制成：黄连8份、竹茹15份、枳实8份、半夏8份、橘红8份、甘草5份、生姜5份、茯苓8份、桔梗8份、紫菀8份、百部15份、白前8份、陈皮8份、艾叶8份、紫苏叶8份、薄荷8份、冰片2份和瓜蒌10份。The embodiments of the present invention provide a composition for clearing the throat, improving the lungs, and quitting smoking, which is prepared from the following traditional Chinese medicine raw materials in parts by weight: 8 parts of Coptis chinensis, 15 parts of Zhuru, 8 parts of Citrus aurantium, 8 parts of Pinellia ternata, 8 parts of orange red parts, 5 parts of licorice, 5 parts of ginger, 8 parts of Poria, 8 parts of Campanulaceae, 8 parts of aster, 15 parts of Baibu, 8 parts of Baiqian, 8 parts of dried tangerine peel, 8 parts of mugwort leaves, 8 parts of perilla leaves, 8 parts of mint, 2 parts of borneol and 10 parts of melon.

该清咽利肺戒烟组合物的制备方法为：The preparation method of the composition for clearing the throat and promoting the lungs and quitting smoking is as follows:

以精油对应的生药质量计，按上述原料的重量份数配比称取市售的黄连精油、竹茹精油、枳实精油、半夏精油、橘红精油、甘草精油、生姜精油、茯苓精油、桔梗精油、紫菀精油、百部精油、白前精油、陈皮精油、艾叶精油、紫苏叶精油、薄荷精油和瓜蒌精油，混合均匀，加入冰片并溶解，即得。In terms of the crude drug quality corresponding to the essential oil, take commercially available Coptis essential oil, Zhuru essential oil, Citrus aurantium essential oil, Pinellia essential oil, tangerine essential oil, licorice essential oil, ginger essential oil, Poria cocos essential oil, Platycodon grandiflorum according to the parts by weight ratio of the above-mentioned raw materials. Essential oil, aster essential oil, Baibu essential oil, Baiqian essential oil, tangerine peel essential oil, Artemisia argyi essential oil, perilla leaf essential oil, peppermint essential oil and Gualou essential oil, mix well, add borneol and dissolve.

实施例5Example 5

本发明实施例提供了一种清咽利肺戒烟组合物，由以下重量份数配比的中药原料制成：黄连12份、竹茹25份、枳实12份、半夏12份、橘红12份、甘草7份、生姜7份、茯苓12份、桔梗12份、紫菀12份、百部25份、白前12份、陈皮12份、艾叶12份、紫苏叶12份、薄荷12份、冰片4份和瓜蒌20份。The embodiment of the present invention provides a composition for clearing the throat, improving the lungs and quitting smoking, which is prepared from the following traditional Chinese medicine raw materials in parts by weight: 12 parts of Coptis chinensis, 25 parts of Zhuru, 12 parts of Citrus aurantium, 12 parts of Pinellia sinensis, 12 parts of orange red parts, 7 parts of licorice, 7 parts of ginger, 12 parts of Poria, 12 parts of Campanulaceae, 12 parts of aster, 25 parts of Baibu, 12 parts of Baiqian, 12 parts of dried tangerine peel, 12 parts of Artemisia argyi, 12 parts of perilla leaves, 12 parts of mint, 4 servings of borneol and 20 servings of melon.

该清咽利肺戒烟组合物的制备方法同实施例4。The preparation method of the composition for clearing the throat and improving the lungs and smoking cessation is the same as that in Example 4.

实施例6Example 6

本发明实施例提供了一种清咽利肺戒烟组合物，由以下重量份数配比的中药原料制成：黄连10份、竹茹20份、枳实10份、半夏10份、橘红10份、甘草6份、生姜6份、茯苓10份、桔梗10份、紫菀10份、百部20份、白前10份、陈皮10份、艾叶10份、紫苏叶10份、薄荷10份、冰片3份、瓜蒌15份和黄芩10份。The embodiment of the present invention provides a composition for clearing the throat, improving the lungs, and quitting smoking, which is prepared from the following traditional Chinese medicine raw materials in parts by weight: 10 parts of Coptis chinensis, 20 parts of Zhuru, 10 parts of Citrus aurantium, 10 parts of Pinellia sinensis, 10 parts of orange red parts, 6 parts of licorice, 6 parts of ginger, 10 parts of Poria, 10 parts of Platycodon grandiflorum, 10 parts of Aster, 20 parts of Bai Bu, 10 parts of Bai Qian, 10 parts of dried tangerine peel, 10 parts of Artemisia argyi, 10 parts of Perilla leaves, 10 parts of Mint, 3 parts of borneol, 15 parts of Gualou and 10 parts of Scutellaria baicalensis.

该清咽利肺戒烟组合物的制备方法为：The preparation method of the composition for clearing the throat and promoting the lungs and quitting smoking is as follows:

按实施例1的制备方法制备黄连精油、竹茹精油、枳实精油、半夏精油、橘红精油、甘草精油、生姜精油、茯苓精油、桔梗精油、紫菀精油、百部精油、白前精油、陈皮精油、艾叶精油、紫苏叶精油、薄荷精油、瓜蒌精油；Prepare Coptis essential oil, Bamboo Ru essential oil, Citrus essential oil, Pinellia essential oil, Tangerine essential oil, Licorice essential oil, Ginger essential oil, Poria cocos essential oil, Platycodon grandiflorum essential oil, Aster essential oil, Baibu essential oil, Baiqian essential oil, Chenpi essential oil according to the preparation method of Example 1 Essential oil, mugwort essential oil, perilla leaf essential oil, peppermint essential oil, guarhou essential oil;

将黄芩加7倍量纯净水蒸馏提取5小时，收集所得油状成分，得黄芩精油。The scutellaria baicalensis was distilled and extracted with 7 times of purified water for 5 hours, and the obtained oily components were collected to obtain the essential oil of scutellaria baicalensis.

将以上各精油混合均匀，加入所述冰片并溶解，即得该清咽利肺戒烟组合物。Mix the above essential oils evenly, add the borneol and dissolve to obtain the composition for clearing the throat, invigorating the lungs and quitting smoking.

实施例7Example 7

本发明实施例提供了一种清咽利肺戒烟组合物，由以下重量份数配比的中药原料制成：黄连9份、竹茹18份、枳实9份、半夏9份、橘红9份、甘草5.5份、生姜5.5份、茯苓9份、桔梗9份、紫菀9份、百部18份、白前9～11份、陈皮9份、艾叶9份、紫苏叶9份、薄荷9份、冰片2.5份、瓜蒌13份和黄芩9份。The embodiment of the present invention provides a composition for clearing the throat, improving the lungs and quitting smoking, which is prepared from the following traditional Chinese medicine raw materials in parts by weight: 9 parts of Coptis chinensis, 18 parts of Zhuru, 9 parts of Citrus aurantium, 9 parts of Pinellia sinensis, 9 parts of orange red parts, 5.5 parts of licorice, 5.5 parts of ginger, 9 parts of Poria, 9 parts of Campanulaceae, 9 parts of Aster, 18 parts of Bai Bu, 9 to 11 parts of Bai Qian, 9 parts of dried tangerine peel, 9 parts of Artemisia argyi, 9 parts of Perilla leaves, 9 parts of Mint 2.5 servings of borneol, 13 servings of Gualou and 9 servings of Scutellaria baicalensis.

该清咽利肺戒烟组合物的制备方法同实施例6。The preparation method of the composition for clearing the throat and improving the lungs and smoking cessation is the same as that in Example 6.

实施例8Example 8

本发明实施例提供了一种清咽利肺戒烟组合物，由以下重量份数配比的中药原料制成：黄连11份、竹茹22份、枳实11份、半夏11份、橘红11份、甘草6.5份、生姜6.5份、茯苓11份、桔梗11份、紫菀11份、百部22份、白前11份、陈皮11份、艾叶11份、紫苏叶11份、薄荷11份、冰片3.5份、瓜蒌17份和黄芩11份。The embodiment of the present invention provides a composition for clearing the throat, invigorating the lungs and quitting smoking, which is prepared from the following traditional Chinese medicine raw materials in parts by weight: 11 parts of Coptis chinensis, 22 parts of Zhuru, 11 parts of Citrus aurantium, 11 parts of Pinellia ternata, 11 parts of orange red parts, 6.5 parts of licorice, 6.5 parts of ginger, 11 parts of Poria, 11 parts of Campanulaceae, 11 parts of Aster, 22 parts of Baibu, 11 parts of Baiqian, 11 parts of dried tangerine peel, 11 parts of Artemisia argyi, 11 parts of Perilla leaves, 11 parts of Mint, 3.5 parts of borneol, 17 parts of Gualou and 11 parts of Scutellaria baicalensis.

该清咽利肺戒烟组合物的制备方法同实施例6。The preparation method of the composition for clearing the throat and improving the lungs and smoking cessation is the same as that in Example 6.

实施例9Example 9

本发明实施例提供了一种清咽利肺戒烟组合物，由以下重量份数配比的中药原料制成：黄连8份、竹茹15份、枳实8份、半夏8份、橘红8份、甘草5份、生姜5份、茯苓8份、桔梗8份、紫菀8份、百部15份、白前8份、陈皮8份、艾叶8份、紫苏叶8份、薄荷8份、冰片2份、瓜蒌10份和黄芩8份。The embodiments of the present invention provide a composition for clearing the throat, improving the lungs, and quitting smoking, which is prepared from the following traditional Chinese medicine raw materials in parts by weight: 8 parts of Coptis chinensis, 15 parts of Zhuru, 8 parts of Citrus aurantium, 8 parts of Pinellia ternata, 8 parts of orange red parts, 5 parts of licorice, 5 parts of ginger, 8 parts of Poria, 8 parts of Campanulaceae, 8 parts of aster, 15 parts of Baibu, 8 parts of Baiqian, 8 parts of dried tangerine peel, 8 parts of mugwort leaves, 8 parts of perilla leaves, 8 parts of mint, 2 parts of borneol, 10 parts of Gualou and 8 parts of Scutellaria baicalensis.

该清咽利肺戒烟组合物的制备方法为：The preparation method of the composition for clearing the throat and promoting the lungs and quitting smoking is as follows:

以精油对应的生药质量计，按上述原料的重量份数配比称取市售的黄连精油、竹茹精油、枳实精油、半夏精油、橘红精油、甘草精油、生姜精油、茯苓精油、桔梗精油、紫菀精油、百部精油、白前精油、陈皮精油、艾叶精油、紫苏叶精油、薄荷精油、瓜蒌精油和黄芩精油，混合均匀，加入冰片并溶解，即得。In terms of the crude drug quality corresponding to the essential oil, take commercially available Coptis essential oil, Zhuru essential oil, Citrus aurantium essential oil, Pinellia essential oil, tangerine essential oil, licorice essential oil, ginger essential oil, Poria cocos essential oil, Platycodon grandiflorum according to the parts by weight ratio of the above-mentioned raw materials. Essential oil, aster essential oil, Baibu essential oil, Baiqian essential oil, tangerine peel essential oil, Artemisia argyi essential oil, Perilla leaf essential oil, peppermint essential oil, Gualou essential oil and Scutellaria baicalensis essential oil, mix well, add borneol and dissolve.

实施例10Example 10

本发明实施例提供了一种清咽利肺戒烟组合物，由以下重量份数配比的中药原料制成：黄连12份、竹茹25份、枳实12份、半夏12份、橘红12份、甘草7份、生姜7份、茯苓12份、桔梗12份、紫菀12份、百部25份、白前12份、陈皮12份、艾叶12份、紫苏叶12份、薄荷12份、冰片4份、瓜蒌20份和黄芩13份。The embodiment of the present invention provides a composition for clearing the throat, improving the lungs and quitting smoking, which is prepared from the following traditional Chinese medicine raw materials in parts by weight: 12 parts of Coptis chinensis, 25 parts of Zhuru, 12 parts of Citrus aurantium, 12 parts of Pinellia sinensis, 12 parts of orange red parts, 7 parts of licorice, 7 parts of ginger, 12 parts of Poria, 12 parts of Campanulaceae, 12 parts of aster, 25 parts of Baibu, 12 parts of Baiqian, 12 parts of dried tangerine peel, 12 parts of Artemisia argyi, 12 parts of perilla leaves, 12 parts of mint, 4 parts of borneol, 20 parts of Gualou and 13 parts of Scutellaria baicalensis.

该清咽利肺戒烟组合物的制备方法同实施例9。The preparation method of the composition for clearing the throat and improving the lungs and smoking cessation is the same as that in Example 9.

实施例11Example 11

本发明实施例提供了以上实施例制得的清咽利肺戒烟组合物在制备清咽利肺戒烟电子烟中的应用。The embodiments of the present invention provide the application of the throat-clearing, lung-clearing, lung-clearing, and smoking-cessation compositions prepared in the above examples in the preparation of the throat-clearing, lung-clearing, and smoking-cessation electronic cigarettes.

该清咽利肺戒烟电子烟的结构如图1和图2所示，由USB充电电池、Typ-C接口、集成电路、电子气流传感器、烟油存储腔、雾化器6个组件构成。其中烟油存储腔用于放置实施例1～10中任一实施例中的清咽利肺戒烟组合物。The structure of the e-cigarette for clearing the throat, improving the lungs and quitting smoking is shown in Figures 1 and 2, and consists of six components: USB rechargeable battery, Typ-C interface, integrated circuit, electronic airflow sensor, e-liquid storage cavity, and atomizer. Wherein, the e-liquid storage cavity is used for placing the throat clearing, lung, lung, and smoking cessation composition in any one of Embodiments 1 to 10.

使用者在使用过程中，通过吸气产生空气流动，在电子气流传感器的作用下激活开关，使清咽利肺戒烟组合物通过雾化器被雾化，再被使用者进入气管到达肺部，发挥清咽、利肺、化痰、凝神静气、降低烟瘾等功效。During use, the user generates air flow through inhalation, and activates the switch under the action of the electronic airflow sensor, so that the composition for clearing the throat, improving the lungs and quitting smoking is atomized by the atomizer, and then the user enters the trachea and reaches the lungs. It has the functions of clearing the throat, benefiting the lungs, resolving phlegm, calming the mind, and reducing cravings for smoking.

试验例1Test Example 1

本试验例提供了上述实施例1～10制备所得清咽利肺戒烟组合物对尼古丁依赖性大鼠的戒断作用。This test example provides the withdrawal effect of the Qingyan Lifei smoking cessation compositions prepared in Examples 1-10 above on nicotine-dependent rats.

1.实验材料1. Experimental materials

1.1动物1.1 Animals

SD大鼠(180-220g)，6-8周龄，60只，雄性。饲养于12h光照/12h黑暗翻转交替，温度22～25℃，湿度40％～70％的清洁级动物房中。实验前大鼠饲养1周左右以适应环境，自由饮水饮食。动物实验按照我国《实验动物福利伦理审查指南》(GB/T35892-2018)要求，规范落实实验动物福利伦理。SD rats (180-220 g), 6-8 weeks old, 60, male. The animals were reared in a clean-grade animal room with a temperature of 22-25°C and a humidity of 40%-70%. Before the experiment, the rats were reared for about 1 week to adapt to the environment, and they could drink water and diet freely. Animal experiments follow the requirements of my country's "Guidelines for Ethical Review of Laboratory Animal Welfare" (GB/T35892-2018), and standardize the implementation of laboratory animal welfare ethics.

1.2实验试剂1.2 Experimental reagents

实施例1～3、6～8所得清咽利肺戒烟组合物。The sore throat, lung, lung and smoking cessation compositions obtained in Examples 1-3 and 6-8.

尼古丁：分析纯，淡黄色油状液体，重庆中烟工业有限责任公司实验室提供，建模前用生理盐水溶解尼古丁制备成尼古丁溶液。Nicotine: analytically pure, light yellow oily liquid, provided by the laboratory of Chongqing China Tobacco Industry Co., Ltd. Before modeling, nicotine was dissolved in physiological saline to prepare a nicotine solution.

2.实验方法2. Experimental method

2.1建立大鼠尼古丁依赖模型并给药干预：2.1 Establish a rat nicotine dependence model and administer drug intervention:

将大鼠按0.4mg/kg的给药剂量皮下注射1mg/ml的尼古丁，每天两次，连续7天；另取同一批次的大鼠10只，作为空白组，按0.4ml/kg的剂量皮下注射生理盐水。The rats were subcutaneously injected with 1 mg/ml of nicotine at a dose of 0.4 mg/kg, twice a day for 7 consecutive days; another 10 rats from the same batch were taken as blank group, at a dose of 0.4 ml/kg Inject normal saline subcutaneously.

在第8天，将注射尼古丁的大鼠随机分组，每组10只，各实施例组分别以对应的实施例1～3、6～8制得的清咽利肺戒烟组合物进行给药，阳性药组给与阳性药。各组别和给药剂量分别为：On the 8th day, the rats injected with nicotine were randomly divided into groups, 10 rats in each group. The positive drug group was given the positive drug. The groups and doses administered are:

实施例1低剂量组：给药剂量为3.2mg/kg；Example 1 Low-dose group: the administration dose was 3.2 mg/kg;

实施例1中剂量组：给药剂量为4.8mg/kg；The dosage group in Example 1: the administration dose is 4.8 mg/kg;

实施例1高剂量组：给药剂量为6.4mg/kg；Example 1 High-dose group: the administration dose was 6.4 mg/kg;

实施例2组：给药剂量为4.8mg/kg；Example 2 group: the administration dose was 4.8 mg/kg;

实施例3组：给药剂量为4.8mg/kg；Example 3 group: the administration dose was 4.8 mg/kg;

实施例6组：给药剂量为4.8mg/kg；Example 6 group: the administration dose was 4.8 mg/kg;

实施例7组：给药剂量为4.8mg/kg；Example 7 group: the administration dose was 4.8 mg/kg;

实施例8组：给药剂量为4.8mg/kg；Example 8 group: the administration dose was 4.8 mg/kg;

阳性药组：给药剂量为4.8mg/kg；Positive drug group: the administration dose was 4.8 mg/kg;

模型组：给予等量生理盐水。Model group: given equal volume of normal saline.

其中阳性药的制备方法为：按清肺排毒汤的配方取各味中药(麻黄9份、炙甘草6份、杏仁9份、生石膏15～30份、桂枝9份、泽泻9份、猪苓9份、白术9份、茯苓15份、柴胡16份、黄芩6份、姜半夏9份、生姜9份、紫菀9份、冬花9份、射干9份、细辛6份、山药12份、枳实6份、陈皮6份、藿香9份)，按实施例6的方法分别制出茯苓、黄芩、生姜、紫菀、陈皮的精油，其余中药按以下方法提取精油：The preparation method of the positive medicine is as follows: according to the formula of Qingfei Paidu Decoction, take each traditional Chinese medicine (9 parts of ephedra, 6 parts of Zhigancao, 9 parts of almond, 15 to 30 parts of raw gypsum, 9 parts of Guizhi, 9 parts of Alisma, pig 9 parts of Atractylodes, 9 parts of Atractylodes, 15 parts of Poria, 16 parts of Bupleurum, 6 parts of Scutellaria, 9 parts of Ginger Pinellia, 9 parts of Ginger, 9 parts of Aster, 9 parts of Winter Flower, 9 parts of Shegan, 6 parts of Asarum, 12 parts of Yam , 6 parts of Fructus Aurantii, 6 parts of tangerine peel, 9 parts of Huoxiang), make respectively the essential oil of Poria cocos, Scutellaria baicalensis, ginger, aster, tangerine peel by the method of embodiment 6, all the other Chinese medicines extract essential oil by the following method:

将麻黄、炙甘草、桂枝、柴胡、姜半夏、藿香分别加4倍量纯净水蒸馏提取4小时，收集所得油状成分，分别得麻黄精油、炙甘草精油、桂枝精油、柴胡精油、姜半夏精油、藿香精油；将杏仁、泽泻、猪苓、白术、冬花、射干、细辛、山药、枳实分别加5倍量纯净水蒸馏提取5小时，收集所得油状成分，分别得杏仁精油、泽泻精油、猪苓精油、白术精油、冬花精油、射干精油、细辛精油、山药精油、枳实精油。Ephedra, Zhigancao, Guizhi, Bupleurum, Ginger Pinellia, and Huoxiang were added with 4 times of purified water for distillation and extraction for 4 hours, and the gained oily components were collected to obtain Ephedra essential oil, Zhigancao essential oil, Guizhi essential oil, Bupleurum essential oil, Ginger Pinellia essential oil, Agaricus essential oil; Almond, Alisma, Polyporus, Atractylodes, Winter Flower, Shegan, Asarum, Chinese yam, Citrus aurantium were added 5 times the amount of purified water for distillation and extraction for 5 hours, the obtained oily components were collected, and almonds were obtained respectively. Essential oil, Alisma essential oil, Polyporus essential oil, Atractylodes essential oil, Winter flower essential oil, Shegan essential oil, Asarum essential oil, Yam essential oil, Citrus essential oil.

将以上精油混合后加入生石膏，即得阳性药。After mixing the above essential oils and adding gypsum, the positive medicine is obtained.

空白组，给药(蒸馏水)剂量为4.8mg/kg。In the blank group, the administration (distilled water) dose was 4.8 mg/kg.

给药方式：吸入，采用如图3所示的装置进行实验：按各组对应的给药剂量取对应重量的清咽利肺戒烟组合物、阳性药或蒸馏水置于样品瓶中，开启加热器(模拟实施例11中电子烟的使用状态)，使待测物扩散至放有大鼠的玻璃缸中，实验过程关闭排气口以防精油流失。20min后去除样品瓶，通入空气，并同时开启排气口，完成玻璃缸内换气，即完成一次给药。Dosing method: inhalation, using the device shown in Figure 3 to carry out the experiment: according to the corresponding dosage of each group, take the corresponding weight of the composition for clearing the throat, promoting the lungs and smoking cessation, the positive drug or distilled water, put it in the sample bottle, and turn on the heater. (simulating the use state of the electronic cigarette in Example 11), the test object was diffused into the glass jar with the rat, and the exhaust port was closed during the experiment to prevent the loss of essential oils. After 20 minutes, the sample bottle was removed, air was introduced, and the exhaust port was opened at the same time to complete the ventilation in the glass cylinder, that is, a drug administration was completed.

每天分别在9:00、12:00、21:00各给药一次，其余时间保持玻璃缸内空气正常流通。共给药3天。The drug was administered once a day at 9:00, 12:00 and 21:00, and the air in the glass cylinder was kept in normal circulation during the rest of the time. A total of 3 days of administration.

3.观察指标3. Observation indicators

3.1旷场实验3.1 Open field experiment

取50cm×50cm×50cm的旷场实验箱，四周及箱底为黑色，箱盖为白色有机玻璃，并装有通风扇和红外摄像装置，用于跟踪记录大鼠在实验箱中的运动轨迹及运动时间。在第3天给药结束60min后，将大鼠放置在实验箱正中央，且每只大鼠在放置时均朝向箱体同一角度，盖好箱盖，记录大鼠在5min内的活动距离和活动时间。记录过程中保持室温为22℃±1℃，并保持室内安静。结果如下所示：Take a 50cm × 50cm × 50cm open field experimental box, the surrounding and bottom of the box are black, the box cover is white plexiglass, and is equipped with a ventilation fan and an infrared camera device to track and record the movement track and movement of the rats in the experimental box. time. On the third day, 60 minutes after the end of the administration, the rats were placed in the center of the experimental box, and each rat faced the same angle of the box when placed. Activity time. During the recording, keep the room temperature at 22°C ± 1°C, and keep the room quiet. The result looks like this:

表1旷场实验结果

Table 1 Results of open field experiments

*表示与模型组相比P＜0.05；#表示与阳性药组相比P＜0.05。* means P<0.05 compared with the model group; # means P<0.05 compared with the positive drug group.

3.2高架十字迷宫3.2 Elevated Cross Labyrinth

在第3天给药结束60min后，将大鼠从中央格面向闭合臂放入迷宫，记录5分钟内的活动情况。观察开放臂进入次数(必须有两只前瓜进入臂内)，开放臂停留时间，闭合臂进入次数，闭合臂停留时间。计算开放臂停留时间比例，开放臂进入次数比例。实验完成后将大鼠取出，将两臂清理干净，喷洒酒精除去气味，用Xeye动物行为学软件进行数据分析。On the third day, 60 minutes after the end of the administration, the rats were put into the maze from the central grid to the closed arm, and the activities within 5 minutes were recorded. Observe the entry times of the open arm (there must be two front melons entering the arm), the dwell time of the open arm, the entry times of the closed arm, and the dwell time of the closed arm. Calculate the proportion of open arm dwell time and the proportion of open arm entry times. After the experiment, the rats were taken out, the arms were cleaned, alcohol was sprayed to remove the odor, and the data was analyzed by Xeye animal behavior software.

结果如下所示：The result looks like this:

表2高架十字迷宫实验结果

Table 2 Experimental results of elevated plus maze

*表示与模型组相比P＜0.05；#表示与阳性药组相比P＜0.05。* means P<0.05 compared with the model group; # means P<0.05 compared with the positive drug group.

3.3呼吸频率3.3 Respiratory rate

在第3天给药结束60min后，测试大鼠的呼吸频率。The respiratory rate of the rats was tested 60 min after the end of the administration on the 3rd day.

结果如下所示：The result looks like this:

表3呼吸频率测试结果

Table 3 Respiratory rate test results

呼吸频率breath rate空白组blank group95.3±5.28*#95.3±5.28*#模型组model group112.9±3.26112.9±3.26实施例1低剂量组Example 1 Low-dose group110.2±4.22110.2±4.22实施例1中剂量组Dosage group in Example 1103.7±4.39*#103.7±4.39*#实施例1高剂量组Example 1 High-dose group95.2±5.17*#95.2±5.17*#实施例2组Example 2 group106.7±4.82*106.7±4.82*实施例3组Example 3 groups105.9±4.69*#105.9±4.69*#实施例6组Example 6 group98.2±3.97*#98.2±3.97*#实施例7组Example 7 groups99.8±4.28*#99.8±4.28*#实施例8组Example 8 groups101.7±4.57*#101.7±4.57*#阳性药组Positive drug group109.9±5.24109.9±5.24

*表示与模型组相比P＜0.05；#表示与阳性药组相比P＜0.05。* means P<0.05 compared with the model group; # means P<0.05 compared with the positive drug group.

3.4定量分析指标3.4 Quantitative analysis indicators

观察指标：咀嚼/错齿；扭体/喘气；颤抖/震颤；及其他症状(舔脚、抓挠和打哈欠)分别按出现频率除以10计1分；眼睑下垂按轻、中、重分别计1、2、3分。Observation indicators: chewing/misaligned teeth; writhing/panting; tremor/tremor; and other symptoms (licking feet, scratching, and yawning) were divided by 10 for 1 point respectively; ptosis was scored as light, moderate, and severe 1, 2, 3 points.

结果如下所示：The result looks like this:

表4定量分析指标结果

Table 4 Quantitative analysis index results

*表示与模型组相比P＜0.05；#表示与阳性药组相比P＜0.05。* means P<0.05 compared with the model group; # means P<0.05 compared with the positive drug group.

按以上方法对实施例4、5、9、10组的清咽利肺戒烟组合物进行试验，同样能够达到减轻尼古丁戒断症状的效果，各方面的数据与模型组相比均有显著性差异。According to the above methods, the throat clearing, lung and smoking cessation compositions of Example 4, 5, 9, and 10 groups were tested, and the effect of alleviating nicotine withdrawal symptoms could also be achieved, and the data in all aspects were significantly different from the model group. .

以上结果证明，本发明提供的清咽利肺戒烟组合物具有显著的减轻尼古丁戒断症状的作用。The above results prove that the composition for clearing the throat and promoting the lungs and smoking cessation provided by the present invention has a significant effect of alleviating the symptoms of nicotine withdrawal.

试验例2Test Example 2

本试验例提供了上述实施例1～5制备所得清咽利肺戒烟组合物对血样饱和度的影响。This test example provides the effect of the Qingyan Lifei smoking cessation compositions prepared in Examples 1 to 5 above on blood sample saturation.

试验例1各组大鼠完成各项检测后，用肝素化的注射器对其进行心脏采血，分别检测血样饱和度。结果如下：Test Example 1 After the rats in each group completed various tests, blood was collected from their hearts with a heparinized syringe, and the saturation of the blood samples was detected respectively. The result is as follows:

表5血氧饱和度检测结果

Table 5 Blood oxygen saturation test results

*表示与模型组相比P＜0.05；#表示与阳性药组相比P＜0.05。* means P<0.05 compared with the model group; # means P<0.05 compared with the positive drug group.

可见，各实施例组能够显著提高大鼠的血氧饱和度。It can be seen that each example group can significantly improve the blood oxygen saturation of rats.

按以上方法对实施例4、5、9、10组的清咽利肺戒烟组合物进行试验，同样能够达到提高血氧饱和度的效果，各方面的数据与模型组相比均有显著性差异。According to the above methods, the throat clearing, lung, lung and smoking cessation compositions of Example 4, 5, 9, and 10 groups were tested, and the effect of improving blood oxygen saturation could also be achieved, and the data in all aspects were significantly different from the model group. .

以上所述仅为本发明的较佳实施例而已，并不用以限制本发明，凡在本发明的精神和原则之内所作的任何修改、等同替换或改进等，均应包含在本发明的保护范围之内。The above descriptions are only preferred embodiments of the present invention and are not intended to limit the present invention. Any modification, equivalent replacement or improvement made within the spirit and principle of the present invention shall be included in the protection of the present invention. within the range.

Claims (10)

Translated fromChinese

1.一种清咽利肺戒烟组合物，其特征在于，由包括以下重量份数配比的中药原料制成：黄连8～12份、竹茹15～25份、枳实8～12份、半夏8～12份、橘红8～12份、甘草5～7份、生姜5～7份、茯苓8～12份、桔梗8～12份、紫菀8～12份、百部15～25份、白前8～12份、陈皮8～12份、艾叶8～12份、紫苏叶8～12份、薄荷8～12份、冰片2～4份和瓜蒌10～20份。1. a throat-clearing and lung-relieving smoking cessation composition, is characterized in that, is made up of the traditional Chinese medicine raw material comprising following parts by weight proportioning: 8～12 parts of Coptis chinensis, 15～25 parts of Bamboo Ru, 8～12 parts of Citrus aurantium, 8-12 parts of Pinellia, 8-12 parts of orange, 5-7 parts of licorice, 5-7 parts of ginger, 8-12 parts of Poria, 8-12 parts of Campanulaceae, 8-12 parts of Aster, 15-25 parts of Bai Bu, 8-12 parts of Baiqian, 8-12 parts of dried tangerine peel, 8-12 parts of mugwort leaves, 8-12 parts of perilla leaves, 8-12 parts of mint, 2-4 parts of borneol and 10-20 parts of melon.2.根据权利要求1所述的清咽利肺戒烟组合物，其特征在于，由包括以下重量份数配比的中药原料制成：黄连9～11份、竹茹18～22份、枳实9～11份、半夏9～11份、橘红9～11份、甘草5.5～6.5份、生姜5.5～6.5份、茯苓9～11份、桔梗9～11份、紫菀9～11份、百部18～22份、白前9～11份、陈皮9～11份、艾叶9～11份、紫苏叶9～11份、薄荷9～11份、冰片2.5～3.5份和瓜蒌13～17份。2. The composition for clearing the throat, improving the lungs and quitting smoking according to claim 1 is characterized in that, it is made of the raw materials of traditional Chinese medicine comprising the following parts by weight: 9～11 parts of Coptis chinensis, 18～22 parts of Bamboo Ru, Fructus Aurantii 9-11 parts, Pinellia 9-11 parts, Orange 9-11 parts, Licorice 5.5-6.5 parts, Ginger 5.5-6.5 parts, Poria 9-11 parts, Platycodon 9-11 parts, Aster 9-11 parts, Hundred parts 18-22 parts, 9-11 parts of Baiqian, 9-11 parts of dried tangerine peel, 9-11 parts of mugwort leaves, 9-11 parts of perilla leaves, 9-11 parts of mint, 2.5-3.5 parts of borneol and 13-17 parts of melon .3.根据权利要求2所述的清咽利肺戒烟组合物，其特征在于，由包括以下重量份数配比的中药原料制成：黄连10份、竹茹20份、枳实10份、半夏10份、橘红10份、甘草6份、生姜6份、茯苓10份、桔梗10份、紫菀10份、百部20份、白前10份、陈皮10份、艾叶10份、紫苏叶10份、薄荷10份、冰片3份和瓜蒌15份。3. throat-clearing, lung-reducing and smoking-cessation composition according to claim 2, is characterized in that, is made up of the traditional Chinese medicine raw material that comprises following parts by weight proportioning: 10 parts of Coptis chinensis, 20 parts of Bamboo Ru, 10 parts of Citrus aurantium, half of 10 parts of summer, 10 parts of orange red, 6 parts of licorice, 6 parts of ginger, 10 parts of Poria, 10 parts of Campanulaceae, 10 parts of aster, 20 parts of Baibu, 10 parts of Baiqian, 10 parts of tangerine peel, 10 parts of mugwort leaves, 10 parts of perilla leaves 10 servings of mint, 3 servings of borneol and 15 servings of gualou.4.根据权利要求1～3任一项所述的清咽利肺戒烟组合物，其特征在于，所述中药原料还包括黄芩8～13份。4 . The composition for clearing the throat, invigorating the lungs and quitting smoking according to any one of claims 1 to 3, wherein the raw material of the traditional Chinese medicine further comprises 8 to 13 parts of Scutellaria baicalensis.5.根据权利要求4所述的清咽利肺戒烟组合物，其特征在于，所述黄芩的重量份数为9～11份。5 . The composition for clearing the throat, invigorating the lungs, and quitting smoking according to claim 4 , wherein the weight part of the skullcap is 9-11 parts. 6 .6.根据权利要求5所述的清咽利肺戒烟组合物，其特征在于，所述黄芩的重量份数为10份。6. The composition for clearing the throat, invigorating the lungs and quitting smoking according to claim 5, characterized in that, the parts by weight of the Scutellaria baicalensis are 10 parts by weight.7.权利要求1～6任一项所述的清咽利肺戒烟组合物的制备方法，其特征在于，包括以下操作：提取除冰片外其余所述中药原料的精油，按上述清咽利肺戒烟组合物中的各原料的重量份数配比将各精油混合均匀，加入所述冰片并溶解，即得所述清咽利肺戒烟组合物；或7. the preparation method of the composition for clearing the throat, invigorating the lungs and smoking cessation according to any one of claims 1 to 6, characterized in that, comprising the following operations: extracting the essential oils of the other described traditional Chinese medicine raw materials except borneol, according to the above-mentioned clearing the throat and improving the lungs The proportion by weight of each raw material in the smoking cessation composition is mixed evenly with each essential oil, and the borneol is added and dissolved to obtain the described throat clearing, lung and smoking cessation composition; or按重量份数配比称取各原料，提取除冰片外其余所述中药原料的精油，将所得精油混合均匀，加入所述冰片并溶解，即得所述清咽利肺戒烟组合物。Weigh each raw material by weight and proportion, extract the essential oils of the other Chinese medicine raw materials except borneol, mix the obtained essential oils evenly, add the borneol and dissolve to obtain the composition for clearing the throat, improving the lungs, and quitting smoking.8.根据权利要求7所述的清咽利肺戒烟组合物的制备方法，其特征在于，所述中药原料的精油的制备方法为：将所述中药原料加3～7倍量纯净水蒸馏提取3～5小时，收集所得油状成分，即得。8. the preparation method of the composition for clearing the throat, promoting the lungs and quitting smoking according to claim 7, is characterized in that, the preparation method of the essential oil of the described Chinese medicine raw material is: adding 3～7 times of pure water to the described Chinese medicine raw material and extracting by distillation After 3 to 5 hours, the obtained oily components are collected and obtained.9.由权利要求7或8的制备方法制得的清咽利肺戒烟组合物在制备清咽利肺戒烟电子烟中的应用。9. The application of the throat-clearing, lung-clearing and smoking-cessation composition prepared by the preparation method of claim 7 or 8 in the preparation of an electronic cigarette for clearing the throat, promoting the lungs and quitting smoking.10.根据权利要求9所述的应用，其特征在于，所述清咽利肺戒烟电子烟设有烟油存储腔，所述清咽利肺戒烟组合物置于烟油存储腔中。10 . The application according to claim 9 , wherein the electronic cigarette for clearing the throat and improving the lungs and smoking cessation is provided with an e-liquid storage cavity, and the composition for clearing the throat and improving the lungs and smoking cessation is placed in the e-liquid storage cavity. 11 .

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