CN114209416A - Chemical ablation balloon catheter, chemical ablation combination product and ablation method - Google Patents

Abstract

Translated fromChinese

本发明公开了一种化学消融球囊导管、化学消融组合产品及消融方法。该化学消融球囊导管包括导管本体以及球囊，所述导管本体具有导丝腔、灌注腔以及充盈腔，所述导管本体的远端具有导丝出口、灌注出口以及充盈出口，沿着所述导管本体的近端至远端方向，所述充盈出口、所述灌注出口以及所述导丝出口依次顺序分布以使得所述导管本体的径向尺寸由近端至远端方向连续减小，所述球囊连接于所述导管本体且与所述充盈出口相通，所述球囊具有未充盈时的第一充盈状态以及充盈时的第二充盈状态。该化学消融球囊导管使用便捷、节时节力、提高了手术效率。

The invention discloses a chemical ablation balloon catheter, a chemical ablation combined product and an ablation method. The chemical ablation balloon catheter includes a catheter body and a balloon, the catheter body has a guide wire cavity, an irrigation cavity and a filling cavity, and the distal end of the catheter body has a guide wire outlet, an irrigation outlet and a filling outlet. From the proximal end to the distal end of the catheter body, the filling outlet, the irrigation outlet and the guide wire outlet are sequentially distributed in order so that the radial dimension of the catheter body decreases continuously from the proximal end to the distal end, so The balloon is connected to the catheter body and communicated with the inflation outlet, and the balloon has a first inflation state when it is not inflated and a second inflation state when it is inflated. The chemical ablation balloon catheter is convenient to use, saves time and effort, and improves the operation efficiency.

Description

Chemical ablation balloon catheter, chemical ablation combined product and ablation method

Technical Field

The invention relates to the field of medical instruments, in particular to a chemical ablation balloon catheter, a chemical ablation combined product and an ablation method.

Background

Atrial fibrillation is the most common tachyarrhythmia in the clinic. The probability of stroke, heart failure and cardiovascular death of patients with atrial fibrillation is obviously increased, and the patients with atrial fibrillation have extremely high disability and death rate and seriously threaten the physical health of people. Currently, radio frequency ablation becomes a first-line treatment method for partial paroxysmal atrial fibrillation patients, but persistent atrial fibrillation is the biggest difficulty in the field of atrial fibrillation ablation due to high recurrence rate and high ablation difficulty, and the reason is that radio frequency energy cannot sufficiently and thoroughly intervene epicardial structures such as Marshall veins and the like to a great extent. Marshall vein is left major vein degeneration residual vestige in embryonic period, it is not merely the epicardial passageway of connecting coronary sinus and left atrium, contains conduction fasciculus, autonomic nerve fibre etc. simultaneously, plays important role in the triggering and maintaining of atrial arrhythmia, such as atrial fibrillation, atrial flutter etc.. Because the Marshall vein is positioned on the epicardium and the periphery of the Marshall vein is wrapped by structures such as fat pads and the like, the catheter ablation difficulty through the endocardium approach is extremely high.

The traditional Marshall vein ablation is a way of thoracotomy or pericardial cavity puncture, but the two methods have large trauma and high complication risk. The waterless alcohol chemical ablation of Marshall vein through catheter is a great technical innovation in the field of atrial fibrillation ablation, and combines electrophysiology and coronary artery manipulation and technology. Marshall vein anhydrous alcohol chemical ablation can improve the ablation effect of persistent atrial fibrillation, can obviously reduce recurrence of atrial fibrillation/atrial velocity, and reduce the recurrence of atrial fibrillation and the possibility of secondary ablation. Through the technology, the event-free survival rate of the continuous atrial fibrillation, the left atrial flutter and the recurrent atrial fibrillation ablation is expected to be improved by 15 percent on the current basis, an innovative technology is provided for the conditions that the atrial fibrillation cannot be achieved and cannot be completely ablated through a catheter, and the ablation efficiency is greatly improved. Marshall vein alcohol ablation treatment of atrial fibrillation is relatively safe, tolerance of a patient is good, heart perforation caused by incomplete ablation or excessive ablation of a catheter is effectively avoided along with proficiency of the technology, surgical complications of catheter ablation are reduced, and the Marshall vein alcohol ablation treatment of atrial fibrillation becomes a hotspot problem in the field of atrial fibrillation treatment in recent years.

The importance of Marshall venous absolute alcohol chemical ablation is more and more emphasized, and more doctors begin to try to apply the operation mode to treat atrial fibrillation. However, the current instruments for Marshall vein absolute ethyl alcohol chemical ablation have certain limitations, and doctors creatively develop catheters and balloon instruments for coronary artery into Marshall vein absolute ethyl alcohol chemical ablation. Because the coronary vein and Marshall vein have tortuous path, narrow drilling angle and small pipe diameter, the Marshall vein and Marshall vein need much time to find out the Marshall vein and establish the channel in the operation process, the prior coaxial catheter (OTW) balloon must withdraw from the guide wire to carry out alcohol perfusion, and the operation is repeated after inserting the guide wire to exchange the catheter for radiography confirmation, which wastes time and labor.

Disclosure of Invention

Based on this, it is necessary to provide a chemical ablation balloon catheter aiming at the problems of inconvenient use, time and labor waste and low efficiency of the existing Marshall vein absolute ethyl alcohol chemical ablation instrument.

The utility model provides a chemical ablation sacculus pipe, includes pipe body and sacculus, the pipe body has the wire chamber of guide, fills the chamber and fills the chamber, the distal end of pipe body has the seal wire export, fills export and fills and to be full of the export, along the near-end to distal end direction of pipe body, fill the export and the seal wire export distributes in proper order, the radial dimension of pipe body reduces by near-end to distal end direction in succession, the sacculus connect in the pipe body and with fill the export and communicate with each other, work as be in first filling state when the sacculus is not full, work as be in the second filling state when the sacculus is full.

In some embodiments, the distal end of the catheter body sequentially forms a first segment, a second segment, a third segment and a fourth segment from the proximal end to the distal end, the radial dimensions of the third segment, the second segment and the first segment are continuously reduced, the guide wire outlet is located at the first segment, the perfusion outlet is located at the second segment, the filling outlet is located at the third segment, the balloon is at least partially connected to the third segment, and the fourth segment extends to the proximal end of the catheter body.

In some of these embodiments, the first section is curved toward the outside of the catheter body.

In some embodiments, the first stage has a first developing slot for mounting a developing material, the first developing slot being capable of full-stage development of the first stage; and/or the port part of the first segment has elasticity.

In some of these embodiments, the first segment has a radial maximum dimension of no greater than 1 mm.

In some embodiments, the distal end of the balloon and the shaft of the balloon are located at the second position, the proximal end of the balloon is located at the third position, and the diameter of the shaft of the balloon is smaller than that of the third position under negative pressure.

In some of these embodiments, the chemical ablation balloon catheter further comprises a visualization ring that is sleeved at the second segment location and is located inside the balloon.

In some of these embodiments, the balloon has an inflated radial dimension of 1mm to 3 mm; and/or the axial length of the balloon is 2-5 mm.

In some of these embodiments, the proximal end of the catheter body has a guidewire junction in communication with the guidewire lumen, a perfusion junction in communication with the perfusion lumen, and a filling junction in communication with the filling lumen.

It is also an object of the present invention to provide a chemical ablation combination product.

A chemical ablation combination product, which comprises a bending sheath tube, a guide wire and the chemical ablation balloon catheter; the tuningout sheath pipe is used for placing at coronary sinus mouth and pass through the seal wire guide chemistry melts the sacculus pipe and gets into coronary sinus, the perfusion chamber radiography that the sacculus pipe was melted to chemistry is in order to confirm Marshall venous position, the sacculus that the sacculus pipe was melted to chemistry is used for shutoff Marshall venous mouth under the second is sufficient state, the perfusion chamber that the sacculus pipe was melted to chemistry is used for realizing melting to Marshall intravenous injection anhydrous alcohol.

It is also an object of the present invention to provide a method of chemical ablation.

A chemical ablation method using said chemical ablation combination product, comprising the steps of:

placing a bending-adjusting sheath tube at a coronary sinus orifice, controlling a guide wire to enter the bending-adjusting sheath tube, and controlling a guide wire cavity of the chemical ablation balloon catheter to be matched with the guide wire so as to realize that the chemical ablation balloon catheter enters a coronary sinus from the bending-adjusting sheath tube along the guide wire;

identifying a Marshall vein position, identifying a Marshall vein orifice and controlling the guide wire to enter the Marshall vein along the Marshall vein orifice through perfusion cavity radiography of the chemical ablation balloon catheter;

and controlling the balloon of the chemical ablation balloon catheter to be in a second filling state so as to seal the Marshall vein opening, and injecting absolute alcohol into the Marshall vein through the perfusion cavity of the chemical ablation balloon catheter to realize ablation.

The chemical ablation balloon catheter is convenient to use, saves time and labor and improves operation efficiency. According to the chemical ablation balloon catheter, the filling outlet, the perfusion outlet and the guide wire outlet are sequentially distributed along the direction from the near end to the far end of the catheter body, so that the radial size of the catheter body is continuously reduced from the near end to the far end, the far end of the catheter body is easy to enter a Marshall vein with the inner diameter of about 1mm, and the convenience in operation is improved. The balloon has a first filling state when the balloon is not filled and a second filling state when the balloon is filled, the Marshall venous orifice can be blocked by the second filling state, the balloon can be pressurized and decompressed by the filling cavity under the condition of keeping the guide wire, and simultaneously the balloon is subjected to alcohol perfusion or radiography by the perfusion cavity, so that the aim of not frequently exchanging the guide wire and the catheter body is fulfilled, and the catheter body is realized; in addition, ablation can be repeated due to insufficient ablation, the guide wire and the catheter body do not need to be exchanged in the whole process, operation is convenient, operation time is greatly shortened, and subsequent operation can be performed after ablation is completed quickly.

Drawings

In order to more clearly illustrate the technical solutions in the embodiments of the present application, the drawings used in the description of the embodiments will be briefly described below. It is obvious that the drawings in the following description are only some embodiments of the application, and that other drawings can be derived from these drawings by a person skilled in the art without inventive effort.

For a more complete understanding of the present application and its advantages, reference is now made to the following descriptions taken in conjunction with the accompanying drawings. Wherein like reference numerals refer to like parts in the following description.

Fig. 1 is a schematic view of a chemical ablation balloon catheter in accordance with an embodiment of the present invention;

fig. 2 is a schematic view of a radial cross-section of a catheter body of a chemical ablation balloon catheter in accordance with an embodiment of the invention;

fig. 3 is a schematic view of a radial cross section of a catheter body of a chemical ablation balloon catheter in accordance with another embodiment of the invention;

fig. 4 is a schematic view of a radial cross section of a catheter body of a chemical ablation balloon catheter in accordance with another embodiment of the invention;

fig. 5 is a schematic view of a chemical ablation balloon catheter according to another embodiment of the present invention in a use state.

Description of the reference numerals

10. A chemical ablation balloon catheter; 110. a catheter body; 111. a guidewire lumen; 112. filling the cavity; 113. filling the cavity; 1141. a first segment bit; 1142. a second segment bit; 1143. a third segment position; 120. a balloon; 130. a developing ring; 141. a guidewire junction; 142. filling a connector; 143. filling the joints;

20. bending the sheath tube;

30. a guide wire;

40. the coronary sinus; 41. the coronary sinus ostium;

50. marshall vein.

Detailed Description

In order to make the aforementioned objects, features and advantages of the present invention comprehensible, embodiments accompanied with figures are described in detail below. In the following description, numerous specific details are set forth in order to provide a thorough understanding of the present invention. This invention may, however, be embodied in many different forms and should not be construed as limited to the embodiments set forth herein.

In the description of the present invention, it is to be understood that the terms "central," "longitudinal," "lateral," "length," "width," "thickness," "upper," "lower," "front," "rear," "left," "right," "vertical," "horizontal," "top," "bottom," "inner," "outer," "clockwise," "counterclockwise," "axial," "radial," "circumferential," and the like are used in the orientations and positional relationships indicated in the drawings for convenience in describing the invention and to simplify the description, and are not intended to indicate or imply that the referenced device or element must have a particular orientation, be constructed and operated in a particular orientation, and are not to be considered limiting of the invention.

Furthermore, the terms "first", "second" and "first" are used for descriptive purposes only and are not to be construed as indicating or implying relative importance or implicitly indicating the number of technical features indicated. Thus, a feature defined as "first" or "second" may explicitly or implicitly include at least one such feature. In the description of the present invention, "a plurality" means at least two, e.g., two, three, etc., unless specifically limited otherwise.

In the present invention, unless otherwise expressly stated or limited, the terms "mounted," "connected," "secured," and the like are to be construed broadly and can, for example, be fixedly connected, detachably connected, or integrally formed; can be mechanically or electrically connected; they may be directly connected or indirectly connected through intervening media, or they may be connected internally or in any other suitable relationship, unless expressly stated otherwise. The specific meanings of the above terms in the present invention can be understood by those skilled in the art according to specific situations.

In the present invention, unless otherwise expressly stated or limited, the first feature "on" or "under" the second feature may be directly contacting the first and second features or indirectly contacting the first and second features through an intermediate. Also, a first feature "on," "over," and "above" a second feature may be directly or diagonally above the second feature, or may simply indicate that the first feature is at a higher level than the second feature. A first feature being "under," "below," and "beneath" a second feature may be directly under or obliquely under the first feature, or may simply mean that the first feature is at a lesser elevation than the second feature.

It will be understood that when an element is referred to as being "secured to" or "disposed on" another element, it can be directly on the other element or intervening elements may also be present. When an element is referred to as being "connected" to another element, it can be directly connected to the other element or intervening elements may also be present. The terms "vertical," "horizontal," "upper," "lower," "left," "right," and the like as used herein are for illustrative purposes only and do not denote a unique embodiment.

Unless defined otherwise, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this invention belongs. The terminology used in the description of the invention herein is for the purpose of describing particular embodiments only and is not intended to be limiting of the invention. As used herein, the term "and/or" includes any and all combinations of one or more of the associated listed items.

It should be noted that in the following description, "proximal" generally refers to the end closer to the physician during normal operation, and correspondingly, "distal" generally refers to the end farther from the physician during normal operation. It is also noted that the radial dimension represents a dimension perpendicular to the axial direction of the catheter body, for example, when the structure of the catheter body is cylindrical, the radial dimension represents the outer diameter.

The embodiment of the application provides a chemicalablation balloon catheter 10, which aims to solve the problems that an existingMarshall vein 50 absolute ethyl alcohol chemical ablation instrument is inconvenient to use, time-consuming, labor-consuming and low in efficiency. The following description will be made with reference to the accompanying drawings.

Fig. 1 shows an exemplary chemicalablation balloon catheter 10 provided in an embodiment of the present application, and fig. 1 is a schematic structural diagram of the chemicalablation balloon catheter 10 provided in an embodiment of the present application. The chemicalablation balloon catheter 10 of the present application can be used for Marshall intravenous 50 ablation.

To more clearly illustrate the structure of the chemicalablation balloon catheter 10, the chemicalablation balloon catheter 10 will be described with reference to the drawings.

Illustratively, referring to fig. 1, a chemicalablation balloon catheter 10 includes acatheter body 110 and aballoon 120.

Thecatheter body 110 has aguidewire lumen 111, aninfusion lumen 112, and aninflation lumen 113. The distal end of thecatheter body 110 has a guidewire exit port, a perfusion exit port, and a filling exit port. Along the near-end to distal end direction ofcatheter body 110, filling export, perfusion export and seal wire export distribute in proper order so that the radial dimension ofcatheter body 110 reduces by near-end to distal end direction in succession, because the internal diameter ofMarshall vein 50 is about 1mm, consequently above-mentioned gradient setting can guarantee that the distal end ofcatheter body 110 smoothly gets intoMarshall vein 50. Theballoon 120 is connected to thecatheter body 110 and communicates with the inflation outlet.Balloon 120 has a first inflated state when not inflated and a second inflated state when inflated, and the second inflated state ofballoon 120 when inflated can achieve occlusion of Marshall venous ostia.

In some embodiments, the locations and specific configurations of theguidewire lumen 111, theperfusion lumen 112, and thefilling lumen 113 on thecatheter body 110 are not limited, for example, as shown in fig. 2, 3, and 4, theguidewire lumen 111 is generally configured with a circular cross-section, and theperfusion lumen 112 and thefilling lumen 113 may be disposed on either side of theguidewire lumen 111 or adjacent thereto.

In some embodiments, referring to fig. 1, the distal end of thecatheter body 110 sequentially forms afirst section 1141, asecond section 1142, athird section 1143, and a fourth section from the proximal end to the distal end. The radial dimensions of thethird segment bit 1143, thesecond segment bit 1142, and thefirst segment bit 1141 are continuously reduced. The guidewire exit is located at thefirst segment position 1141. The irrigation outlet is located at thesecond stage 1142. The filling outlet is located at thethird segment 1143.Balloon 120 is at least partially attached tothird segment 1143. The fourth segment extends to the proximal end of thecatheter body 110.

In some embodiments, referring to FIG. 1, thefirst section 1141 is curved toward the outside of the catheter body. Thefirst section 1141 is bent and inclined at a certain angle with the axial direction of thecatheter body 110, so that the guide wire outlet of thefirst section 1141 always points to one side of the catheter wall in the coronary vein, and thecatheter body 110 is rotated at the moment, so that thefirst section 1141 rotates in the circumferential direction in the vein, and can be quickly and conveniently found and enter any branch vein such as theMarshall vein 50.

In some embodiments, referring to FIG. 1,first stage 1141 has a first developer slot for receiving developer material. The first developing slot is provided with a developing material, and the first developing slot can realize the full-section development of thefirst section 1141. The port of thefirst segment 1141 is flexible, which facilitates real-time determination of the specific position of thefirst segment 1141. The developing material can be gold, platinum or platinum alloy, and the developing material is used for improving the positioning accuracy in the operation. Preferably, thefirst stage 1141 is designed for full stage visualization, the port portion of thefirst stage 1141 is made of a softer material so that it does not damage tissue during use, and the curved portion of thefirst stage 1141 is made of a harder material to achieve retention of its shape. Under the X-ray, the curved shape and orientation of thefirst section 1141 can be seen, which is convenient for the operator to operate and use.

In some of these embodiments, the radial maximum dimension of thefirst segment 1141 is no greater than 1 mm. Whenfirst section position 1141 cylindric structure, the external diameter offirst section position 1141 is not more than 1mm, so set up, be convenient forfirst section position 1141 get into theMarshall vein 50 about the internal diameter is 1mm fast.

In some of these embodiments,second staging location 1142 has a second developer slot that mounts developer material. The distal end of theballoon 120 and the shaft of theballoon 120 are located at thesecond section 1142, and the proximal end of theballoon 120 is located at thethird section 1143, and preferably, the proximal end of theballoon 120 abuts against thethird section 1143. The diameter of the shaft of theballoon 120 at negative pressure is smaller than the diameter of thethird section 1143, so that the proximal end of theballoon 120 just covers the inflation opening.

In some embodiments, referring to fig. 1, the chemicalablation balloon catheter 10 further includes avisualization ring 130. The developingring 130 is sleeved at thesecond section 1142 and located inside theballoon 120. The two ends of thevisualization ring 130 within theballoon 120 are used to indicate the specific location of theballoon 120 in the vessel. The material of the developingring 130 may be gold, platinum or platinum alloy, etc., and the developingring 130 is used to improve the accuracy of the positioning during the operation.

In some of these embodiments, the inflated radial dimension ofballoon 120 is 1mm to 3 mm; the inflation of theballoon 120 to the desired diameter can be controlled according to the actual vessel size. And/or the axial length of theballoon 120 is 2-5 mm. Thefirst section 1141 can enter a very thin blood vessel such as aMarshall vein 50, meanwhile, thethird section 1143 on the third gradient and theballoon 120 are driven to enter a blood vessel opening such as a Marshall vein opening for plugging, thefirst section 1141 enters the Marshall vein and drives theballoon 120 at thesecond section 1142 to enter, thethird section 1143 does not enter the Marshall vein, and theballoon 120 is plugged at the Marshall vein opening. The portion of thecatheter body 110 after the third gradient (in the proximal direction) need not enter theMarshall vein 50. It should be noted that the size of theballoon 120 is designed to be able to close the mouth of the blood vessel, so that the inside of theMarshall vein 50 is sufficiently ablated, the size of theballoon 120 should not be too large, and when the size of theballoon 120 is too large, the normal blood flow at other parts of the coronary vein is obstructed. In this embodiment, the radial maximum dimension of theballoon 120 is 1 mm-3 mm, the axial length of theballoon 120 is 2-5 mm, the Marshall vein opening can be blocked, and the normal blood flow of other parts of the coronary vein cannot be blocked, and theballoon 120 with the above dimensions is small in size, and can be conveyed, charged and decompressed more smoothly, and the time can be saved.

In some of these embodiments, theballoon 120 is asemi-compliant balloon 120.

In some embodiments, referring to fig. 1, the proximal end of thecatheter body 110 has aguidewire port 141 in communication with theguidewire lumen 111, aninfusion port 142 in communication with theinfusion lumen 112, and aninfusion port 143 in communication with theinfusion lumen 113.

It is also an object of the present invention to provide a chemical ablation combination product.

Referring to fig. 5, a chemical ablation assembly includes a bendingsheath 20, aguide wire 30 and the chemicalablation balloon catheter 10. The bendingsheath 20 is used to place in thecoronary ostium 41 and guide the chemicalablation balloon catheter 10 over theguidewire 30 into thecoronary sinus 40. Theperfusion lumen 112 of the chemicalablation balloon catheter 10 was visualized to confirm theMarshall vein 50 location. Theballoon 120 of the chemicalablation balloon catheter 10 is used to occlude the Marshall vein ostium in the second, inflated state. Theinfusion lumen 112 of the chemicalablation balloon catheter 10 is used to inject anhydrous alcohol into theMarshall vein 50 to achieve ablation.

It is also an object of the present invention to provide a method of chemical ablation.

A chemical ablation method using the chemical ablation combination product, comprising the steps of:

referring to fig. 5, fig. 5 is a schematic view of a chemical ablation balloon catheter according to another embodiment of the present invention in a use state, the bendingadjustment sheath 20 is placed at thecoronary sinus ostium 41, thecontrol guide wire 30 enters the bendingadjustment sheath 20, and theguide wire cavity 111 of the chemicalablation balloon catheter 10 is controlled to cooperate with theguide wire 30, so that the chemicalablation balloon catheter 10 enters thecoronary sinus 40 from the bendingadjustment sheath 20 along theguide wire 30.

TheMarshall vein 50 is identified by imaging through theperfusion lumen 112 of the chemicalablation balloon catheter 10, the Marshall vein ostium is identified, thefirst section 1141 of the chemical ablation balloon catheter is bent to point and fall into the Marshall vein ostium by twisting, and theguide wire 30 is then steered into theMarshall vein 50 along the Marshall vein ostium.

And controlling theballoon 120 of the chemicalablation balloon catheter 10 to be in a second filling state to seal off the Marshall vein orifice, and injecting absolute alcohol into theMarshall vein 50 through theperfusion cavity 112 of the chemicalablation balloon catheter 10 to realize ablation.

In conclusion, the chemicalablation balloon catheter 10 is convenient to use, saves time and labor and improves the operation efficiency. According to the chemicalablation balloon catheter 10, the filling outlet, the perfusion outlet and the guide wire outlet are sequentially distributed along the direction from the near end to the far end of thecatheter body 110, so that the radial size of thecatheter body 110 is continuously reduced from the near end to the far end, the far end of thecatheter body 110 is easy to enter aMarshall vein 50 with the inner diameter of about 1mm, and the convenience in operation is improved. Theballoon 120 has a first filling state when the balloon is not filled and a second filling state when the balloon is filled, the Marshall venous orifice can be blocked by the second filling state, theballoon 120 can be pressurized and decompressed by the fillingcavity 113 under the condition that theguide wire 30 is reserved, and meanwhile, theballoon 120 is perfused or contrasted by alcohol through theperfusion cavity 112, so that the aim of exchanging theguide wire 30 and thecatheter body 110 without frequency is fulfilled, and thecatheter body 110 is realized, and the operations of angiography, blood vessel selection, blockage and ablation are completed under the condition that theguide wire 30 is reserved; in addition, ablation can be repeated due to insufficient ablation, theguide wire 30 and thecatheter body 110 do not need to be exchanged in the whole process, the operation is convenient, the operation time is greatly shortened, and subsequent operation can be performed after the ablation is quickly completed.

In the foregoing embodiments, the descriptions of the respective embodiments have respective emphasis, and for parts that are not described in detail in a certain embodiment, reference may be made to related descriptions of other embodiments.

The technical features of the embodiments described above may be arbitrarily combined, and for the sake of brevity, all possible combinations of the technical features in the embodiments described above are not described, but should be considered as being within the scope of the present specification as long as there is no contradiction between the combinations of the technical features.

The above-mentioned embodiments only express several embodiments of the present invention, and the description thereof is more specific and detailed, but not construed as limiting the scope of the present invention. It should be noted that, for a person skilled in the art, several variations and modifications can be made without departing from the inventive concept, which falls within the scope of the present invention. Therefore, the protection scope of the present patent shall be subject to the appended claims.

Claims (10)

1. The utility model provides a chemical ablation sacculus pipe, its characterized in that includes pipe body and sacculus, the pipe body has wire guide chamber, fills the chamber and fills the chamber, the distal end of pipe body has the seal wire export, fills export and the abundant export, along the near-end to distal end direction of pipe body, fill the export and the seal wire export distributes in proper order, the radial dimension of pipe body reduces by near-end to distal end direction in succession, the sacculus connect in the pipe body and with the abundant export communicates with each other, works as the sacculus is in first abundant state when not abundant, works as be in the second abundant state when the sacculus is abundant.

2. The chemical ablation balloon catheter according to claim 1, wherein the distal end of the catheter body is sequentially formed into a first section, a second section, a third section and a fourth section from the proximal end to the distal end, the radial dimensions of the third section, the second section and the first section are continuously reduced, the guide wire outlet is located at the first section, the perfusion outlet is located at the second section, the filling outlet is located at the third section, the balloon is at least partially connected to the third section, and the fourth section extends to the proximal end of the catheter body.

3. The chemical ablation balloon catheter of claim 2, wherein the first section is curved toward the outside of the catheter body;

and/or the first section is provided with a first developing slot position for installing a developing material, and the first developing slot position can realize the full-section development of the first section; and/or the port part of the first segment has elasticity.

4. The chemical ablation balloon catheter according to any one of claims 2 to 3 wherein the first segment has a radial maximum dimension of no more than 1 mm.

5. The chemical ablation balloon catheter according to any one of claims 2 to 3, wherein the distal end of the balloon and the shaft of the balloon are located at the second section, the proximal end of the balloon is located at the third section, and the diameter of the shaft of the balloon is smaller than that of the third section under negative pressure.

6. The chemical ablation balloon catheter according to claim 5, further comprising a visualization ring, wherein the visualization ring is sleeved at the second section and is located inside the balloon.

7. The chemical ablation balloon catheter according to any one of claims 1 to 3 or 6, wherein the balloon has an inflated radial dimension of 1mm to 3 mm; and/or the axial length of the balloon is 2-5 mm.

8. The chemical ablation balloon catheter according to any one of claims 1 to 3 or 6 wherein the proximal end of the catheter body has a guidewire connector in communication with the guidewire lumen, an infusion connector in communication with the infusion lumen, and an infusion connector in communication with the infusion lumen.

9. A chemical ablation combination product, which is characterized by comprising a bending sheath, a guide wire and the chemical ablation balloon catheter of any one of claims 1-8; the tuningout sheath pipe is used for placing at coronary sinus mouth and through the seal wire guide chemistry melts the sacculus pipe and gets into coronary sinus, right the flooding chamber radiography of chemistry melting sacculus pipe is in order to confirm Marshall venous position, the sacculus of chemistry melting sacculus pipe is used for shutoff Marshall venous mouth under the second is sufficient state, the flooding chamber of chemistry melting sacculus pipe is used for realizing ablating to Marshall intravenous injection anhydrous alcohol.

10. A method of chemical ablation using the chemical ablation combination of claim 9, comprising the steps of:

placing a bending adjusting sheath tube at a coronary sinus orifice, controlling a guide wire to enter the bending adjusting sheath tube, controlling a guide wire cavity of the chemical ablation balloon catheter to be matched with the guide wire, and enabling the chemical ablation balloon catheter to enter a coronary sinus from the bending adjusting sheath tube along the guide wire;

identifying a Marshall vein position, identifying a Marshall vein orifice and controlling the guide wire to enter the Marshall vein along the Marshall vein orifice through perfusion cavity radiography of the chemical ablation balloon catheter;

and controlling the balloon of the chemical ablation balloon catheter to be in a second filling state so as to seal the Marshall vein opening, and injecting absolute alcohol into the Marshall vein through the perfusion cavity of the chemical ablation balloon catheter to realize ablation.

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