PCT国内申请，说明书已公开。PCT domestic application, the description has been published.
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201910459299X | 2019-05-29 | ||
| CN201910459299 | 2019-05-29 | ||
| CN201910741177 | 2019-08-12 | ||
| CN201910741177X | 2019-08-12 | ||
| CN201911130068 | 2019-11-18 | ||
| CN2019111300680 | 2019-11-18 | ||
| CN202010076525 | 2020-01-23 | ||
| CN2020100765259 | 2020-01-23 | ||
| CN202010188909 | 2020-03-17 | ||
| CN202010188909X | 2020-03-17 | ||
| CN2020104094200 | 2020-05-14 | ||
| CN202010409420 | 2020-05-14 | ||
| PCT/CN2020/093284WO2020239076A1 (en) | 2019-05-29 | 2020-05-29 | Pyridazinone derivatives as thyroxine receptor-β agonists and application thereof |
| Publication Number | Publication Date |
|---|---|
| CN114174282Atrue CN114174282A (en) | 2022-03-11 |
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202080051869.2APendingCN114174282A (en) | 2019-05-29 | 2020-05-29 | Pyridazinone derivatives as thyroxine receptor-beta agonists and uses thereof |
| Country | Link |
|---|---|
| CN (1) | CN114174282A (en) |
| WO (1) | WO2020239076A1 (en) |
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| CN116178479A (en)* | 2022-09-09 | 2023-05-30 | 上海博璞诺科技发展有限公司 | Preparation method of begoniin methyl ether |
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| WO2007009913A1 (en)* | 2005-07-21 | 2007-01-25 | F. Hoffmann-La Roche Ag | Pyridazinone derivatives as thyroid hormone receptor agonists |
| WO2014043706A1 (en)* | 2012-09-17 | 2014-03-20 | Madrigal Pharmaceuticals, Inc. | Method of synthesizing thyroid hormone analogs and polymorphs thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| WO2007009913A1 (en)* | 2005-07-21 | 2007-01-25 | F. Hoffmann-La Roche Ag | Pyridazinone derivatives as thyroid hormone receptor agonists |
| WO2014043706A1 (en)* | 2012-09-17 | 2014-03-20 | Madrigal Pharmaceuticals, Inc. | Method of synthesizing thyroid hormone analogs and polymorphs thereof |
| CN111320609A (en)* | 2018-12-13 | 2020-06-23 | 拓臻股份有限公司 | THR β receptor agonist compound and preparation method and application thereof |
| Title |
|---|
| MARTHA J. KELLY等: "Discovery of 2-[3, 5-Dichloro-4-(5-isopropyl-6-oxo-1, 6-dihydropyridazin-3-yloxy)phenyl]-3, 5-dioxo-2, 3, 4, 5-tetrahydro[1, 2, 4]triazine-6-carbonitrile (MGL-3196), a Highly Selective Thyroid Hormone Receptor β Agonist in Clinical Trials for the Treatment of Dyslipidemia", JOURNAL OF MEDICINAL CHEMISTRY, vol. 57, no. 10, pages 3912, XP055436939, DOI: 10.1021/jm4019299* |
| Publication number | Publication date |
|---|---|
| WO2020239076A1 (en) | 2020-12-03 |
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| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
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| WD01 | Invention patent application deemed withdrawn after publication | Application publication date:20220311 | |
| WD01 | Invention patent application deemed withdrawn after publication |