CN114129835A - Atomization catheter, atomization drug delivery system, control method, computer equipment and drug delivery equipment suitable for multiphase fluid - Google Patents

Abstract

The application discloses an atomization catheter suitable for multiphase fluid, which comprises a catheter body, wherein one end of the catheter body is a near end, the other end of the catheter body is a far end capable of extending into a bronchus, a channel capable of conveying fluid from the near end to the far end is arranged in the catheter body, an atomization head is arranged at the far end of the catheter body, and the fluid in the channel is atomized by the atomization head and then output; the atomizing head is internally provided with an atomizing chamber for mixing multiphase fluid, and the fluid is atomized through the atomizing chamber. The utility model provides an atomizing pipe diameter is thinner, can go deep into the unable lung section that gets into of endoscope and carry out accurate atomizing and dose, and through targeting atomizing and dose, the drug effect is used in patient affected part more fast more accurately, avoids the liquid medicine to remain in oral cavity, nasal cavity.

Description

Atomization catheter, atomization drug delivery system, control method, computer equipment and drug delivery equipment suitable for multiphase fluid

Technical Field

The application relates to the field of medical instruments, in particular to an atomizing catheter, an atomizing drug delivery system, a control method, computer equipment and drug delivery equipment which can be used for treating bronchial diseases and are suitable for multiphase fluid.

Background

When the treatment is performed under a clinical endoscope, an atomization administration mode is usually needed to be matched, so that the injected medicine liquid can be uniformly distributed, the uniformity of the combination of related tissues (such as bronchial mucosa and gastrointestinal tract mucosa) and medicines is improved, and the impact injury possibly caused by the traditional direct injection to the tissues is reduced to the maximum extent.

The existing nebulizers are used for administering drugs by inhalation, and liquid drugs are decomposed into aerosol of fine particles or droplets, so that the patients using the drugs can inhale and absorb the drug more efficiently.

The existing atomization equipment has single administration form and poor atomization effect, and the treatment effect needs to be further improved.

Disclosure of Invention

The application provides an atomizing pipe that can intervene intrabronchial and release treatment material, atomization effect is better, and the mode of dosing is nimble, can carry out the target to the small size focus and administer, further improves administration efficiency and treatment.

The application relates to an atomization catheter suitable for multiphase fluid, which comprises a catheter body, wherein one end of the catheter body is a near end, the other end of the catheter body is a far end capable of extending into a bronchus, a channel capable of conveying fluid from the near end to the far end is arranged in the catheter body, an atomization head is arranged at the far end of the catheter body, and the fluid in the channel is atomized by the atomization head and then output;

the atomizing head is internally provided with an atomizing chamber for mixing multiphase fluid, and the fluid is atomized through the atomizing chamber.

The application provides an atomizing pipe compares with traditional atomizer, and the body external diameter is littleer, and has certain flexibility, can get into the lung deep, and accurate dosing. The size parameters of the tube body such as the outer diameter, the length and the like are not strictly limited, but at least can extend into the bronchus to reach the focus part.

Several alternatives are provided below, but not as an additional limitation to the above general solution, but merely as a further addition or preference, each alternative being combinable individually for the above general solution or among several alternatives without technical or logical contradictions.

Optionally, the tube body is in a multi-tube form, at least two tubes are arranged side by side or inside and outside in a nested manner, and each tube can be configured independently or an integrated multi-cavity tube is adopted.

The atomization conduit can convey multiphase fluid, each phase of fluid is respectively and correspondingly provided with a fluid channel, and each fluid channel extends independently.

Optionally, a pipe joint is fixed to the proximal end of the pipe body, and the pipe joint includes:

a manifold having a plurality of input ends and an output end, the output ends communicating with respective fluid passages within the body;

and each joint is communicated with one input end of the bus piece.

Each input end corresponds to a phase fluid, the confluence piece receives the multiphase fluid, but the multiphase fluid is not mixed, and the fluid passing through the confluence piece still flows in the pipe body along the respective channel.

Optionally, the confluence piece has two input ends, wherein one input end is communicated with a first connector for connecting a gas phase or a liquid phase, and the other input end is communicated with a second connector for connecting a liquid phase or a gas phase.

The two inputs are of different fluid phases, one of which is a gas phase and the other is a liquid phase, or both are liquid phases.

Optionally, a first branch and a second branch extend from each input end inside the bus bar respectively, and the two branches converge and keep isolated from each other when adjacent to the output end.

The manifold serves to concentrate the flow channels of the inputs, but not mix.

Optionally, the first branch and the second branch are adjacent to the output end of the bus bar, wherein one branch is distributed on the periphery of the other branch.

One branch is positioned at the central position, and the other branch is distributed around the branch, so that the structure is more compact.

The present application also provides an aerosolized delivery system comprising:

a perfusion device for supplying a fluid containing a therapeutic substance;

the atomization catheter is communicated with the perfusion device and is used for receiving the fluid and outputting the fluid into a bronchus after atomization;

the sampling device is used for acquiring the state parameters of the fluid;

and the control device is connected with the sampling device and is used for receiving the state parameters and correspondingly controlling the perfusion device.

The nebulizing administration system may be an aerosolizing catheter as described in the previous embodiments, and the fluid containing the therapeutic substance is introduced into the aerosolizing catheter through the infusion device until it is applied to the lesion site.

The present application also provides a method for controlling an aerosolization system for aerosolizing and delivering a fluid comprising a therapeutic substance into a bronchus, the method comprising:

acquiring a state parameter of the fluid;

generating a corresponding control signal according to the state parameter;

driving a perfusion device by the control signal to regulate the supply of the fluid.

The control method of the atomization drug delivery system adjusts the state parameters of the fluid to be optimal by monitoring the state parameters of the fluid.

The present application also provides a control device of an aerosol delivery system for atomizing a fluid containing a therapeutic substance and outputting the fluid into a bronchus, the control device comprising:

a first module for obtaining a state parameter of a fluid;

the second module is used for generating a corresponding control signal according to the state parameter;

a third module for driving a perfusion device by the control signal to adjust the supply of the fluid.

The respective modules in the above control device may be wholly or partially implemented by software, hardware, and a combination thereof. The modules can be embedded in a hardware form or independent from a processor in the computer device, and can also be stored in a memory in the computer device in a software form, so that the processor can call and execute operations corresponding to the modules.

The present application further provides a computer device configured to an aerosolization system for aerosolizing a fluid comprising a therapeutic substance and outputting the aerosolized fluid into a bronchus, the computer device comprising a memory and a processor, the memory storing a computer program, the processor implementing the following steps when executing the computer program:

acquiring a state parameter of the fluid;

generating a corresponding control signal according to the state parameter;

driving a perfusion device by the control signal to regulate the supply of the fluid.

The present application also provides a drug delivery device for treating a pulmonary disease, the drug delivery device being an aerosolization catheter as described herein.

The utility model provides an atomizing pipe atomization effect is better, and the mode of dosing is nimble, can go deep into the unable lung section that gets into of endoscope and carry out accurate atomizing and dose, and through targeting atomizing and dose, the drug effect is used in patient affected part more fast more accurately, avoids the liquid medicine to remain in oral cavity, nasal cavity.

Drawings

FIG. 1 is a schematic diagram of an atomization conduit according to an embodiment of the present disclosure;

FIG. 2 is a schematic view of the proximal fitting portion of FIG. 1;

FIG. 3 is an exploded view of the coupling portion of FIG. 2;

FIG. 4 is a schematic view of the internal structure of the pipe joint portion of FIG. 1;

FIG. 5 is a schematic view of the butt end of the pipe joint;

FIG. 6 is a schematic view of the butt end of the pipe body with the pipe joint;

FIG. 7 is a schematic view of the distal atomizing head of FIG. 1;

FIG. 8 is a schematic view of the atomizing head of FIG. 7 at another angle;

FIG. 9 is an exploded view of the atomizing head portion of FIG. 8;

FIG. 10 is a schematic view of the atomizing head of FIG. 9 at another angle;

FIG. 11 is an exploded view of the atomizing head of FIG. 10;

FIG. 12 is a schematic view of the atomizing head of FIG. 11 at another angle;

FIG. 13 is a perspective view of a flow splitter in the atomizing head;

FIG. 14 is a perspective view of an atomizing chamber in the atomizing head;

FIG. 15 is a front view of the atomizing head;

FIG. 16 is a sectional view taken along line A-A of FIG. 15;

fig. 17 is an enlarged view of a portion B in fig. 16;

FIG. 18 is a block diagram of a nebulized delivery system according to an embodiment of the present application;

FIG. 19 is a flow chart illustrating a control method according to an embodiment of the present application;

FIG. 20 is a block diagram of a control device according to an embodiment of the present application;

fig. 21 is a block diagram of a computer device according to an embodiment of the present application.

The reference numerals in the figures are illustrated as follows:

100. a pipe body; 110. an outer tube; 120. an inner tube; 130. a first channel; 140. a second channel;

200. a pipe joint; 210. a first joint; 220. a second joint; 230. a bus bar; 231. a first branch; 231', a first branch; 232. a second branch circuit; 232' and a second branch; 233. an output end; 234. a first branch pipe; 235. a second branch pipe;

400. an atomizing head; 410. a first cannula; 420. a second cannula; 430. a first communication pipe; 440. a second communicating pipe; 450. an atomization chamber; 451. an inner cavity; 452. an outer chamber wall; 453. a distal chamber wall; 454. an inner chamber wall; 460. a first nozzle; 470. a second nozzle; 480. a flow divider; 481. a cover body; 482. an opening; 483. and a shunt hole.

Detailed Description

The technical solutions in the embodiments of the present application will be clearly and completely described below with reference to the drawings in the embodiments of the present application, and it is obvious that the described embodiments are only a part of the embodiments of the present application, and not all of the embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present application.

It will be understood that when an element is referred to as being "connected" to another element, it can be directly connected to the other element or intervening elements may also be present. When a component is referred to as being "disposed on" another component, it can be directly on the other component or intervening components may also be present.

Unless defined otherwise, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this application belongs. The terminology used in the description of the present application herein is for the purpose of describing particular embodiments only and is not intended to be limiting of the application. As used herein, the term "and/or" includes any and all combinations of one or more of the associated listed items.

In the existing oral or nasal cavity atomization administration mode, because the airway of a human body is very long, atomized particles are difficult to reach the far end of the lung, most of the atomized particles are deposited at the positions of the mouth, the nose and a main bronchus, and accurate administration cannot be carried out; in addition, the medicine cannot be deeply administrated into the air passage due to the size limitation of the apparatus, the treatment effect is not good, and improvement is needed.

Referring to fig. 1 to 17, in an embodiment of the present application, an atomizing catheter is provided, which includes atube 100, one end of thetube 100 is a proximal end, and the other end is a distal end capable of extending into a bronchus, a channel capable of conveying a fluid from the proximal end to the distal end is formed inside thetube 100, anatomizing head 400 is disposed at the distal end of thetube 100, and the fluid in the channel is atomized by theatomizing head 400 and then output;

theatomizing head 400 has anatomizing chamber 450 therein for mixing a multiphase fluid, which is atomized through theatomizing chamber 450.

The atomizing catheter of this embodiment compares with traditional atomizer, andbody 100 external diameter is littleer, and has certain flexibility, can get into the deep of lung, and accurate dosing. The outer diameter, length, etc. of thetube 100 are not critical, but at least can extend into the bronchi to reach the lesion site, and preferred embodiments are provided below to achieve better results.

Depending on the nature of the therapeutic substance, the fluid itself may be in the liquid or gas phase, or a more complex mixing system, and atomization is intended to further disperse the fluid into smaller particles to facilitate absorption and uniform administration.

Thetube body 100 may be made of metal or composite material, which provides necessary mechanical properties and intervention safety, and may be in the form of a single tube, multiple tubes, etc. according to the requirement of fluid delivery, when multiple tubes are used, at least two tubes may be arranged side by side or nested inside and outside, and each tube may be configured independently or as an integrated multi-lumen tube.

In order to facilitate the passage in the thinner bronchus, the outer diameter of thetube body 100 is generally not more than 1.2 mm-2.0 mm, for example, the outer diameter of the atomizing catheter is 1.8mm, and the tube body can reach the lung section which can not be reached by the endoscope, so that accurate atomizing administration can be realized.

Since the nebulizing catheter of the present application can extend into the bronchi, its length can be adapted accordingly, for example, the length of thetube 100 is 800 mm-1200 mm.

Multiphase fluids such as gases and liquids, and at least one of them may carry a therapeutic substance, determined in particular according to its physicochemical properties. The gas and the liquid can form tiny bubbles after mixing and intersection, and the bubbles carry liquid drops to be sprayed out, thereby integrally achieving the atomization effect.

Theatomizing chamber 450 has at least a first fluid inlet, a second fluid inlet, and a nozzle for atomized fluid, although the first and second fluid inlets may also meet in advance adjacent to theatomizing chamber 450, i.e. share a common fluid inlet.

To optimize the administration area, in one embodiment, theaerosolization chamber 450 has a plurality of orifices for aerosolized fluid, at least two of which are oriented differently.

With reference to the direction of extension of thetube 100, the nozzle orifice may be oriented axially and distally, radially outwardly, tangentially, or at a slight angle to the directions described above.

Theatomization chamber 450 is disposed in plural for atomization effect, and extends along the circumferential direction of thetube 100. The atomizingchambers 450 are radially disposed about the axis of thetubular body 100.

To facilitate interventional delivery, in one embodiment, theatomizing head 400 is a radially compressible structure having opposing compressed and released states. The compressible structure can adopt a net cage structure, a winding structure and the like.

Thecompressed atomizing head 400 is convenient to pass through the body under the compressed state, can be released as required after being adjacent to a focus, can finish administration once especially for the focus with a large area, does not need to adjust the position for many times, and compresses theatomizing head 400 when being required to be recovered, and is loaded on other pipe fittings to be withdrawn out of the body.

Formultiple nebulizing chambers 450, the fluid may be delivered in a manifold, with branches near thenebulizing chambers 450 for distribution into theindividual nebulizing chambers 450, or in multiple lines in parallel, for the same fluid.

Of course, to facilitate the tubing arrangement, a manifold delivery is typically used between the inlet and atomizing conduits, and multiple tubes may be used in parallel as desired after the inlet into thetube 100.

The proximal end of thetube 100 is generally connected to a fluid-conveying infusion or storage device, and for ease of assembly, a fitting 200, such as a conventional luer fitting or the like, may be pre-secured to the proximal end of thetube 100, either by threading or snap-fitting to facilitate quick connection to an external line.

The pipe joint 200 may adopt a single interface or a plurality of parallel interfaces according to different fluids, when a plurality of interfaces are provided, the pipe joint 200 may adopt a three-way mode, a four-way mode, or the like, and a control valve may be configured for at least one interface, or certainly, the control valve may also adopt an external or detachable mode, and is connected to the pipe joint 200 only when necessary.

Referring to fig. 2 to 6, the pipe joint 200 includes:

a manifold 230 having a plurality of input ends and anoutput end 233, the output ends 233 communicating with respective fluid passageways within thetubular body 100;

a plurality of connectors, each of which communicates with one of the input terminals of thebus bar 230.

For example, when a two-phase fluid input is used, theconfluence element 230 has two input ends, wherein one input end is communicated with thefirst connector 210 for accessing a gas phase or a liquid phase, and the other input end is communicated with thesecond connector 220 for accessing a liquid phase or a gas phase.

The two connections are connected to a fluid, one of which is in liquid phase and the other is in gas phase, for example, thefirst connection 210 is connected to gas phase and thesecond connection 220 is connected to liquid phase, and vice versa.

Inside thebus bar 230, afirst branch 231 and asecond branch 232 extend from the respective input ends, and the two branches converge and remain isolated from each other when they are adjacent to theoutput end 233. After being gathered together, thepipe body 100 can be more conveniently butted.

In one embodiment, a first leg 231 'and a second leg 232' are adjacent theoutput end 233 of thebus 230, with one leg being distributed about the periphery of the other leg.

For example, the second branches 232 'are distributed at the outer circumference of the first branches 231'. The distribution mode can be that the whole circle is wound on the periphery or the periphery is distributed at intervals.

The spacing is further advantageous for conveying the fluid conveyed by the second branch 232' in a multi-channel parallel manner inside thetubular body 100, for example at theoutput end 233 of theconfluence member 230, where:

afirst branch pipe 234, the first branch 231' is communicated with thefirst branch pipe 234,

a plurality ofsecond branch pipes 235, the second branch pipes 232' are communicated with all thesecond branch pipes 235, and the plurality ofsecond branch pipes 235 are arranged around the periphery of thefirst branch pipe 234 at intervals.

First branch pipe 234 and the plurality ofsecond branch pipes 235 integrally form a plug structure, which facilitates quick assembly withpipe body 100.

Accordingly, thetube body 100 is a multi-lumen tube, and each lumen (i.e., fluid passage) in the multi-lumen tube communicates with a corresponding branch tube on thejunction block 230. When the junction is mated, each branch pipe on thejunction 230 can be inserted into the corresponding channel to achieve communication. After being inserted, the two parts can be relatively fixed in a bonding or interference fit mode.

The number of channels and the distribution of the interface portions in the multi-lumen tube should be matched with the branch tubes on thejunction 230, and if necessary, matched fool-proof structures can be provided for positioning and plugging.

In the figure, 7 channels are provided in the multi-cavity tube, which can convey gas in the center and 6 liquid at the periphery.

Each channel in thebarrel 100 extends distally and communicates with a corresponding fluid inlet on theatomizing head 400. In one embodiment, a centralfirst channel 130 is included, and a plurality ofsecond channels 140 are located at the periphery of thefirst channel 130.

To accommodate the design of the multiphase fluid, theatomizing head 400 in one embodiment includes:

a plurality of atomizingchambers 450, each atomizingchamber 450 having a plurality of fluid inlets and a spray orifice for the atomized fluid;

a plurality of cannulas, each cannula being in plug communication with a corresponding fluid channel in thebody 100;

and each cannula is connected to a corresponding fluid inlet in theatomizing chamber 450 through a corresponding communication pipe.

The cross-sectional shapes of the cannulas and the communicating tubes are not strictly limited, such as circular, rectangular and the like, and the fluid state can be regulated and controlled through reasonable arrangement of the cross-sectional areas.

One of the plurality of insertion tubes is afirst insertion tube 410, and the rest are a plurality ofsecond insertion tubes 420 distributed on the periphery of thefirst insertion tube 410.

The respectivefirst cannulas 410 interface with thefirst channels 130 and the plurality ofsecond cannulas 420 correspond to each of thesecond channels 140.

To facilitate the distribution of the fluid, in an embodiment, thefirst cannula 410 is connected to all nebulizingchambers 450 by first radially distributedcommunication tubes 430, and eachsecond cannula 420 is connected to at least onenebulizing chamber 450 by a correspondingsecond communication tube 440.

In one embodiment, the plurality ofnebulizing chambers 450 are distributed annularly, and eachsecond cannula 420 accesses two circumferentiallyadjacent nebulizing chambers 450.

Eachsecond cannula 420 is distributed between two circumferentiallyadjacent nebulizing chambers 450.

In one embodiment, for eachsecond cannula 420, there are two second communicatingtubes 440 coupled to thenebulizing chamber 450 on the corresponding side. The fluid distribution is more uniform and reasonable, the insertion pipes and the communicating pipes can avoid interference as much as possible, and the occupied space is saved.

In order to optimize the structure, in an embodiment, thefirst connection pipe 430 includes a plurality of branch pipes according to different radiation directions, for thesame atomization chamber 450, one branch pipe connected to theatomization chamber 450 is provided, and twosecond connection pipes 440 connected to theatomization chamber 450 are provided and come from differentsecond insertion pipes 420, and the twosecond connection pipes 440 are located at two sides of the branch pipe connected to theatomization chamber 450.

The plurality of branch pipes are preferably uniformly distributed radially in the circumferential direction. Furthermore, theatomizing head 400 has a rotational symmetric structure as a whole, and since there are 6 atomizingchambers 450 in the figure, the included angle between adjacent atomizingchambers 450 is 60 degrees, and the other parts are the same.

In order to further optimize the distribution, an included angle region is formed between two adjacent branch tubes, and eachsecond insertion tube 420 of the plurality ofsecond insertion tubes 420 is arranged in a corresponding included angle region.

For eachsecond cannula 420, two second communicatingtubes 440 are disposed in a substantially V-shape, and extend from thesecond cannula 420 to theatomizing chamber 450 located at the radial outer side of thetubular body 100.

The communication position of the twosecond communication pipes 440 and thesecond cannula 420 is preferably on the side of thesecond cannula 420 facing thefirst cannula 410, i.e. the radially inner side of thetubular body 100.

The number of branches is the same as the number ofsecond cannulae 420 andnebulizing chamber 450, so that a one-to-one match is achieved, 6 in the figure, and in other embodiments, 2-10, such as 4-8.

The direction that each communicating pipeinserts corresponding atomizer 450 can influence atomizing effect to a certain extent, in order in the embodiment, insert thisatomizer 450 along same orientation to all communicating pipes ofsame atomizer 450.

In a preferred embodiment, all the communication pipes for thesame nebulizing chamber 450 extend radially outwards of thetubular body 100 and join therespective nebulizing chamber 450.

I.e. radially to thetubular body 100, all fluid inlets of thenebulizing chamber 450 are inside. The structure is more compact.

All cannulae are on the proximal side of thenebulizing chamber 450 in the axial direction of thebarrel 100. With respect to theatomizing head 400 as a whole, after each cannula is inserted into a channel in thebarrel 100, each communication tube and theatomizing chamber 450 are located at the distal side of the outside of thebarrel 100.

All the branch pipes and the communicating pipes are arranged approximately in a same plane and abut against the far end face of thepipe body 100.

For proper distribution of the drug delivery, in one embodiment, the aerosolizingchamber 450 is provided with two orifices oriented axially distally along thetubular body 100, afirst orifice 460 and radially outwardly along thetubular body 100, asecond orifice 470.

Theatomizing chamber 450 includes chamber walls defining an interior 451, with orifices opening in the chamber walls on opposite sides, such as afirst orifice 460 opening in adistal chamber wall 453, asecond orifice 470 opening in anouter chamber wall 452, and fluid inlets opening in aninner chamber wall 454. The fluids of different phases are mixed in theinner cavity 451 and atomized and sprayed out.

In order to improve the mixing and atomizing effect, aflow divider 480 is disposed in theatomizing chamber 450, wherein one phase fluid is mixed with another phase fluid after passing through theflow divider 480.

In one embodiment, theflow divider 480 is acover 481 with anopening 482 on one side, and thecover 481 is provided with a plurality of flow dividing holes 483, and one of the fluid inlets communicating with theatomizing chamber 450 is in butt joint with theopening 482 of thecover 481.

In one embodiment, thecover 481 is a hollow cubic structure, and the side walls of the other five sides except theopening 482 are distributed with a plurality of branch flow holes 483.

The size of the dispensing orifice 483 may be varied depending on the material to be dispensed, such as the viscosity of the fluid, the dispersion of the therapeutic material or the particle size, and is typically in the range of 5 microns to 100 microns, for example.

Theatomizing chamber 450 is divided into an inner chamber and an outer chamber by thehousing 481, wherein one phase fluid passes into the inner chamber and the other phase fluid passes into the outer chamber.

Referring to fig. 17, in an embodiment, thefirst connection pipe 430 is connected to theopening 482 of theflow divider 480, i.e., connected to the inner chamber, and thesecond connection pipe 440 is connected to the outer chamber.

The fluid (for example, gas) output from the first communicatingpipe 430 enters the outer chamber through the plurality of branch holes 483 on thecover 481 and is mixed with the liquid to form bubbles, and the bubbles carry liquid droplets to be output through the nozzles on the wall of theatomizing chamber 450. Due to the arrangement of the plurality of nozzles facing to each other, when the focus of the lung is positioned on two sides of the bronchial wall, the liquid medicine can be accurately sprayed.

Referring to fig. 18, in some embodiments, there is also provided an aerosolized delivery system comprising:

a perfusion device for supplying a fluid containing a therapeutic substance;

the atomization catheter is communicated with the perfusion device and is used for receiving the fluid and outputting the fluid into a bronchus after atomization;

the sampling device is used for acquiring the state parameters of the fluid;

and the control device is connected with the sampling device and is used for receiving the state parameters and correspondingly controlling the perfusion device.

The nebulizing administration system of this embodiment may be implemented as the nebulizing catheter of each of the embodiments above, and the fluid containing the therapeutic substance is introduced into the nebulizing catheter through the infusion device until it is applied to the lesion site.

The infusion device is mainly fluid powered, achieves a certain flow rate and can be adjusted as required, for example by using a controllable fluid delivery pump or the like, also in view of the structure and control of the pump itself.

The perfusion apparatus is configured according to the state and kind of fluid, and may be connected to theadapter 200 at the proximal end of the nebulizing catheter in a flexible manner, and may be provided with a control device at a desired location.

The sampling device can collect relevant parameters as required to be used as a control basis, wherein the state parameters of the fluid comprise at least one of temperature, pressure and flow.

For auxiliary operation, the sampling device also collects an image signal of a focus part and/or a state signal of the focus part.

The image signal is convenient for visualization operation, and can be used as real-time reference and comparison, and the state signal of the focus part can reflect the treatment process, such as electric signals of current, impedance, etc., or temperature, etc.

The sampling device also collects patient physiological signals in order to keep track of the patient's physiological state during the course of performing the treatment. Such as at least one of an electrocardiogram signal, a blood signal, and the like.

As a nebulizing administration system, a plurality of specific devices may be involved, the sampling device also taking the operating state of the relevant device, for example of the perfusion device and/or of the sampling device, as a monitoring or control basis, in order to know the state of the respective device. The specific equipment can be rotating speed, working current, working temperature, pressure and the like.

The fluid loaded with the therapeutic substance may be either pre-dispensed or mixed in real time with the movement of the fluid, and in one embodiment, the aerosolized delivery system further comprises a storage device for storing at least one of the fluid and the therapeutic substance.

The storage means may be arranged according to the physicochemical properties and the dosage of the fluid or therapeutic substance.

The therapeutic substance itself may be delivered in a single fluid, depending on the purpose of the treatment and the condition of the lesion, for example, the therapeutic substance itself may be a fluid, or the therapeutic substance may be carried in a gas phase fluid, or the therapeutic substance may be carried in a liquid phase fluid.

Or a multiphase fluid is conveyed in the atomizing conduit, for example, the fluid comprises a gas phase fluid and a liquid phase fluid, and the two-phase fluid preferably enters the atomizing conduit respectively and then is mixed and atomized at the atomizing head.

In order to facilitate the operation of the nebulizing catheter, in one embodiment, the nebulizing delivery system further comprises an assisting device which acts on the nebulizing catheter to change the relative position of the nebulizing catheter to the lesion site.

In one embodiment, the nebulizing administration system further comprises a display device for outputting the status parameters directly or after processing, such as video and audio.

In one embodiment, there is provided a drug delivery device for treating a pulmonary disease, the drug delivery device being an aerosolization catheter as described in the various embodiments above.

The lung diseases can be especially aimed at the lung diseases with focus at the bronchial position by combining the structural characteristics of the atomizing catheter.

In one embodiment, the present application provides a method for administering a drug for treating a pulmonary disease, comprising inserting an aerosolization catheter as described in the various embodiments above into a focal site within a bronchial tube, aerosolizing a fluid comprising a therapeutic substance through the aerosolization catheter, and delivering the fluid to the focal site.

The pulmonary disease is at least one of phlegm, tuberculosis, fungal infection and tumor.

The therapeutic substance is at least one of phlegm-eliminating medicine, tuberculosis treating medicine, fungal infection treating medicine and tumor treating medicine.

When the aerosol is applied specifically, the aerosol can be used for ICU patients to inhale aerosol phlegm-reducing medicines, tuberculosis patients to inhale aerosol tuberculosis medicines, fungal infection treatment medicines or tumor treatment medicines, and the like.

Referring to fig. 19, the present application further provides a method for controlling an aerosolization system for aerosolizing and delivering a fluid comprising a therapeutic substance into a bronchus, the method comprising:

acquiring a state parameter of the fluid;

generating a corresponding control signal according to the state parameter;

driving a perfusion device by the control signal to regulate the supply of the fluid.

It should be understood that, although the steps in the flowchart of fig. 19 are shown in order as indicated by the arrows, the steps are not necessarily performed in order as indicated by the arrows. The steps are not performed in the exact order shown and described, and may be performed in other orders, unless explicitly stated otherwise. Moreover, at least a portion of the steps in fig. 19 may include multiple sub-steps or multiple stages that are not necessarily performed at the same time, but may be performed at different times, and the order of performance of the sub-steps or stages is not necessarily sequential, but may be performed in turn or alternately with other steps or at least a portion of the sub-steps or stages of other steps.

In one embodiment, as shown in fig. 20, there is provided a control device of an aerosolization delivery system for aerosolizing and outputting a fluid containing a therapeutic substance into a bronchus, the control device comprising:

a first module for obtaining a state parameter of a fluid;

the second module is used for generating a corresponding control signal according to the state parameter;

a third module for driving a perfusion device by the control signal to adjust the supply of the fluid.

For specific limitations of the control device of the nebulized delivery system, reference may be made to the above limitations of the control method of the nebulized delivery system, which are not described in detail herein.

The respective modules in the above control device may be wholly or partially implemented by software, hardware, and a combination thereof. The modules can be embedded in a hardware form or independent from a processor in the computer device, and can also be stored in a memory in the computer device in a software form, so that the processor can call and execute operations corresponding to the modules.

In one embodiment, a computer device is provided, which may be a terminal, and its internal structure diagram may be as shown in fig. 21. The computer device includes a processor, a memory, a network interface, a display screen, and an input device connected by a system bus. Wherein the processor of the computer device is configured to provide computing and control capabilities. The memory of the computer device comprises a nonvolatile storage medium and an internal memory. The non-volatile storage medium stores an operating system and a computer program. The internal memory provides an environment for the operation of an operating system and computer programs in the non-volatile storage medium. The network interface of the computer device is used for communicating with an external terminal through a network connection. The computer program is executed by a processor to implement a method of controlling an aerosolized delivery system. The display screen of the computer device may be a liquid crystal display screen or an electronic ink display screen, and the input device of the computer device may be a touch layer covered on the display screen, a key, a track ball or a touch pad arranged on the casing 340 of the computer device, or an external keyboard, a touch pad or a mouse, etc.

In one embodiment, there is also provided a computer device configured to an aerosolization system for aerosolizing and outputting a fluid containing a therapeutic substance into a bronchus, the computer device comprising a memory and a processor, the memory storing a computer program, the processor implementing the following steps when executing the computer program:

acquiring a state parameter of the fluid;

generating a corresponding control signal according to the state parameter;

driving a perfusion device by the control signal to regulate the supply of the fluid.

When the computer program is executed, the specific definition of the implementation steps can be referred to the above definition of the control method of the nebulization delivery system, and will not be described in detail herein.

Those skilled in the art will appreciate that the architecture shown in fig. 21 is merely a block diagram of some of the structures associated with the disclosed aspects and is not intended to limit the computing devices to which the disclosed aspects apply, as particular computing devices may include more or less components than those shown, or may combine certain components, or have a different arrangement of components.

The technical features of the embodiments described above may be arbitrarily combined, and for the sake of brevity, all possible combinations of the technical features in the embodiments described above are not described, but should be considered as being within the scope of the present specification as long as there is no contradiction between the combinations of the technical features. When technical features in different embodiments are represented in the same drawing, it can be seen that the drawing also discloses a combination of the embodiments concerned.

The above-mentioned embodiments only express several embodiments of the present application, and the description thereof is more specific and detailed, but not construed as limiting the claims. It should be noted that, for a person skilled in the art, several variations and modifications can be made without departing from the concept of the present application, which falls within the scope of protection of the present application.

Claims (10)

1. An atomization catheter suitable for multiphase fluid comprises a catheter body, and is characterized in that one end of the catheter body is a near end, the other end of the catheter body is a far end capable of extending into a bronchus, a channel capable of conveying fluid from the near end to the far end is arranged inside the catheter body, an atomization head is arranged at the far end of the catheter body, and the fluid in the channel is atomized by the atomization head and then output;

the atomizing head is internally provided with an atomizing chamber for mixing multiphase fluid, and the fluid is atomized through the atomizing chamber.

2. An atomisation catheter for multiphase fluids according to claim 1 wherein the body is in the form of a manifold, at least two tubes being arranged side by side or nested inside and outside, each tube being independently configurable or being an integral multi-lumen tube.

3. The atomization catheter for a multiphase fluid according to claim 2, wherein a pipe joint is fixed to the proximal end of the pipe body, and the pipe joint comprises:

a manifold having a plurality of input ends and an output end, the output ends communicating with respective fluid passages within the body;

and each joint is communicated with one input end of the bus piece.

4. The atomization conduit suitable for multiphase fluids according to claim 3, wherein the confluence member has two input ends, one of the input ends is communicated with a first connector for connecting a gas phase or a liquid phase, and the other input end is communicated with a second connector for connecting a liquid phase or a gas phase.

5. An atomisation conduit for a multiphase fluid as claimed in claim 3, wherein a first branch and a second branch extend from each input end within the manifold, the branches converging and remaining isolated adjacent the output end.

6. The atomization conduit suitable for a multiphase fluid of claim 5, wherein a first branch and a second branch are adjacent to the output end of the manifold, wherein one branch is distributed around the periphery of the other branch.

7. An aerosolized delivery system, comprising:

a perfusion device for supplying a fluid containing a therapeutic substance;

an atomising catheter according to any of claims 1 to 6 in communication with the irrigation means for receiving the fluid and outputting it into the bronchi after atomisation;

the sampling device is used for acquiring the state parameters of the fluid;

and the control device is connected with the sampling device and is used for receiving the state parameters and correspondingly controlling the perfusion device.

8. A method of controlling the aerosolization system of claim 7, wherein the aerosolization system is configured to aerosolize a fluid comprising a therapeutic substance for delivery into a bronchus, the method comprising:

acquiring a state parameter of the fluid;

generating a corresponding control signal according to the state parameter;

driving a perfusion device by the control signal to regulate the supply of the fluid.

9. A computer device configured as in claim 7, wherein the aerosolized delivery system is configured to aerosolize and deliver a fluid comprising a therapeutic substance into a bronchus, the computer device comprising a memory and a processor, the memory storing a computer program, the processor implementing the computer program when executing the computer program:

acquiring a state parameter of the fluid;

generating a corresponding control signal according to the state parameter;

driving a perfusion device by the control signal to regulate the supply of the fluid.

10. A drug delivery device for the treatment of pulmonary diseases, wherein the drug delivery device is an atomising catheter as claimed in any one of claims 1 to 6.

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