CN114098898A - Impact waveguide tube of non-airtight saccule and directional medicine feeding method thereof - Google Patents

Abstract

The invention discloses an impact waveguide tube of a non-closed balloon and a directional drug delivery method thereof, and the impact waveguide tube comprises a catheter, wherein the catheter is provided with an axial pipeline and a guide wire inner cavity penetrating through the catheter; the catheter penetrates through the balloon, two ends of the balloon are hermetically arranged with the catheter, the balloon carries a medicament, micropores are formed in the balloon, and the balloon can be inflated through a medium; a shockwave electrode carried by and encapsulated within the balloon, the shockwave electrode being arranged along an axial direction of the catheter and capable of generating shockwaves that propagate through the medium. The invention uses the shock wave technology to deliver the medicine coated in the non-closed saccule or on the surface of the saccule into the blood vessel, provides a new medicine delivery technology, can directionally inject the medicine into the endothelial tissue, has more accurate medicine delivery, can avoid unnecessary medicine waste, and is more beneficial to improving the treatment effect.

Description

Impact waveguide tube of non-airtight saccule and directional medicine feeding method thereof

Technical Field

The invention relates to the technical field of medical instruments, in particular to an impact waveguide tube of a non-airtight balloon and a directional drug delivery method thereof.

Background

Coronary atherosclerotic heart disease is characterized by coronary artery angiogenesis and atherosclerotic lesion, resulting in stenosis or obstruction of blood vessel lumen, myocardial ischemia, anoxia or necrosis, also known as coronary heart disease. Coronary heart disease is commonly treated by medication, intervention and surgery. The interventional therapy is obviously superior to the simple drug therapy due to the obvious curative effect, small wound, less pain of patients and the same total curative effect as the coronary artery bypass grafting, and the technology is favored by clinicians and patients.

In 1977, Gruentzig successfully performed the first balloon angioplasty (PTCA) procedure in the world with a balloon catheter for a patient with a stenosis in the anterior descending proximal coronary artery, and initiated a new era of coronary intervention. In ten years, the saccule support technology is rapidly developed, becomes smaller in size and stronger in expansion force, and meanwhile, certain clinical experience is accumulated.

From the technical aspect, the use of the steerable balloon catheter greatly improves the success rate of lesion passing, and particularly, the monorail technology (rapid exchange system) only comprises a second inner cavity at the far end of 10-25cm, so that the technical difficulty of single-person operation is reduced. The small balloon, containing different coatings or lubricants, reduces the system friction and thus makes it relatively easy to pass through the lesion.

Currently, pure balloon angioplasty is rarely applied as a separate means in coronary intervention, and the main effects of balloon dilatation are lesion pretreatment before stent implantation and high-pressure post-dilatation after stent implantation. Since the primary mechanisms of lumen enlargement are plaque rupture and over-stretching of the entire vessel wall, the primary limitation of balloon angioplasty is also the development of acute vessel occlusion and restenosis that results from this.

At present, shock wave balloons are all closed liquid-filled balloons, an electric arc generator is arranged in each balloon, each high-voltage pulse enables an arc to be formed between electrodes, the arcs enable steam bubbles to be formed, shock waves are generated when each steam bubble is broken, and the effect enables the pressure in the balloons to be rapidly increased. The drug eluting balloon is expanded in a blood vessel by the balloon coated with drugs on the surface, and the drugs are uniformly coated on the vessel wall, so that the problem of the stenosis of the blood vessel of a patient is solved without implanting a stent. Compared with DES, the drug balloon has many advantages, such as strong vascular adaptability, low thrombus risk, and capability of coping with in-stent restenosis, but the method cannot accurately control the drug loss of the drug entering the lesion part and cannot achieve the curative effect of treating the lesion well.

Disclosure of Invention

The invention aims to provide an impact waveguide tube of a non-closed balloon and a directional drug delivery method thereof, which are used for solving the problems in the prior art, so that drugs can be directionally injected into endothelial tissues, and the improvement of the treatment effect is facilitated.

In order to achieve the purpose, the invention provides the following scheme:

the invention provides a shock wave guide tube of a non-closed balloon, which comprises

A catheter having an axial line and a guidewire lumen therethrough;

the catheter penetrates through the balloon, two ends of the balloon are hermetically arranged with the catheter, the balloon carries a medicament, micropores are formed in the balloon, and the balloon can be inflated through a medium;

a shockwave electrode carried by and encapsulated within the balloon, the shockwave electrode being arranged along an axial direction of the catheter and capable of generating shockwaves that propagate through the medium.

Preferably, the sacculus is multilayer cyst cavity structure, every layer of cyst cavity is provided with the micropore, and every layer of cyst cavity is respectively communicated with the pipeline in the conduit.

Preferably, the balloon is of a two-layer balloon cavity structure, and the micropores on each layer of balloon cavity are arranged in a staggered manner.

Preferably, the material of sacculus is medical nylon, the micropore equipartition is on the surface of every layer of bag chamber and the diameter is 1um-50 um.

A directional medicine delivery method of an impact waveguide tube adopting the non-airtight balloon at least comprises the following steps: the method comprises the steps of firstly guiding the non-closed balloon to the focus of a blood vessel of a patient, guiding normal saline, developing solution and liquid medicine into the balloon through a pipeline in a catheter, controlling a shock wave generator to release shock waves, and in the shock wave treatment process, enabling the liquid medicine to prop open micropores in the balloon to flow out of the balloon and directly reach the focus.

Preferably, the physiological saline and the developing solution are introduced into the balloon at a first set pressure, after the shock wave treatment, a liquid medicine is introduced into the balloon through the catheter, the balloon is increased to a second set pressure through the liquid medicine, and micropores in the balloon are opened.

Preferably, the first set pressure is 1MPa to 4MPa, and the second set pressure is 5MPa to 10 MPa.

Preferably, the saccule is of a two-layer sac cavity structure, the outer sac cavity is used for containing liquid medicine for treatment, and the inner sac cavity is used for containing normal saline and developing solution.

Compared with the prior art, the invention has the following technical effects:

the invention uses the shock wave technology to deliver the medicine coated in the non-closed saccule or on the surface of the saccule into the blood vessel, provides a new medicine delivery technology, can directionally inject the medicine into the endothelial tissue, has more accurate medicine delivery, can avoid unnecessary medicine waste, and is more beneficial to improving the treatment effect.

Drawings

In order to more clearly illustrate the embodiments of the present invention or the technical solutions in the prior art, the drawings needed in the embodiments will be briefly described below, and it is obvious that the drawings in the following description are only some embodiments of the present invention, and it is obvious for those skilled in the art to obtain other drawings without creative efforts.

FIG. 1 is a schematic view of the structure of a non-hermetic balloon shock waveguide of the present invention in use;

FIG. 2 is a schematic diagram of one configuration of a shock waveguide of the non-hermetic balloon of the present invention;

FIG. 3 is a schematic view of another configuration of a shock waveguide of the non-hermetic balloon of the present invention;

wherein: 1-non-closed sacculus shock wave guide tube, 2-guide tube, 3-sacculus, 4-shock wave electrode, 5-micropore and 6-medium.

Detailed Description

The technical solutions in the embodiments of the present invention will be clearly and completely described below with reference to the drawings in the embodiments of the present invention, and it is obvious that the described embodiments are only a part of the embodiments of the present invention, and not all of the embodiments. All other embodiments, which can be obtained by a person skilled in the art without inventive effort based on the embodiments of the present invention, are within the scope of the present invention.

The invention aims to provide an impact waveguide tube of a non-closed balloon and a directional drug delivery method thereof, which are used for solving the problems in the prior art, so that drugs can be directionally injected into endothelial tissues, and the improvement of the treatment effect is facilitated.

In order to make the aforementioned objects, features and advantages of the present invention comprehensible, embodiments accompanied with figures are described in further detail below.

As shown in fig. 1 to 3: the present embodiment provides a non-hermetic balloon ballistic waveguide 1 comprising acatheter 2, thecatheter 2 having an axial line and a guidewire lumen extending through thecatheter 2.

The medical balloon is characterized by comprising aballoon 3, acatheter 2 penetrates through theballoon 3, two ends of theballoon 3 are hermetically arranged with thecatheter 2, theballoon 3 carries medicine,micropores 5 are formed in theballoon 3, and theballoon 3 can be inflated through amedium 6; themedium 6 may include physiological saline, a developing solution, and a medical solution for treating a disease. Theballoon 3 is oblong and in use theballoon 3 can be inserted into an artery or vein of the body.

Theshock wave electrode 4, thecatheter 2 carries and is encapsulated in thesaccule 3, and a plurality ofshock wave electrodes 4 are arranged along the axial direction of thecatheter 2 and can generate shock waves which are transmitted through themedium 6. The electric arc shock wave generator may further comprise a plurality of electrodes adapted to contact the liquid, wherein there may be at least one negative electrode, and a plurality of positive electrodes connected in series, such that the shock wave source is configured to propagate through the liquid and impinge upon the calcified region.

Thesacculus 3 is multilayer bag chamber structure, all is provided withmicropore 5 on every layer of bag chamber, and every layer of bag chamber communicates with the pipeline in thepipe 2 respectively. Preferably, theballoon 3 is of a two-layer sac cavity structure, andmicropores 5 on each layer of sac cavity are arranged in a staggered mode. The material ofsacculus 3 is medical nylon, andmicropore 5 equipartition is on the surface of every layer of bag chamber and the diameter is 1um-50um, can bear certain fluid pressure and do not expand the weeping, ensures going on smoothly of shock wave, sends the focus department with the liquid medicine orientation simultaneously, improves the utilization efficiency of liquid medicine.

A directional medicine feeding method of the shock waveguide 1 adopting thenon-airtight balloon 3 at least comprises the following steps: firstly, guiding thenon-closed balloon 3 to the focus of a blood vessel of a patient, introducing physiological saline, developing solution and liquid medicine into theballoon 3 through a pipeline in thecatheter 2, controlling a shock wave generator to release shock waves, and in the shock wave treatment process, enabling the liquid medicine to propopen micropores 5 on theballoon 3 and flow out of theballoon 3 to reach the focus directly. The physician may also continue to generate shock waves in theballoon 3 to cause the liquid drug to flow out of theballoon 3 more quickly, or the drug coating applied to theballoon 3 may be released more quickly into the blood while promoting absorption of the drug by the intimal cells of the blood vessel.

The normal saline and the developing solution can be introduced into thesaccule 3 at a first set pressure, after the shock wave treatment, the liquid medicine is introduced into thesaccule 3 through thecatheter 2, and thesaccule 3 is increased to a second set pressure through the liquid medicine to prop open themicropores 5 on thesaccule 3. The first set pressure is 1MPa-4MPa, and the second set pressure is 5MPa-10 MPa.

Thesacculus 3 is a two-layer sac cavity structure, the outer layer sac cavity (annular cavity) is used for containing liquid medicine for treatment, the inner layer sac cavity is used for containing normal saline and developing solution, the normal saline and the developing solution with certain pressure can be used at one time, and the normal saline and the developing solution with certain pressure can be supplemented all the time to keep the pressure, so that the effect of shock waves is guaranteed.

The embodiment uses the shock wave technique to send the medicine that is notairtight sacculus 3 in orsacculus 3 surface coating to the blood vessel intradermally, provides a new medicine transport technique, and the medicine can be by directional injection to endothelial tissue in, send the medicine more accurate, can avoid unnecessary medicine extravagant, is favorable to the improvement of treatment more.

The principle and the implementation mode of the present invention are explained by applying specific examples in the present specification, and the above descriptions of the examples are only used to help understanding the method and the core idea of the present invention; meanwhile, for a person skilled in the art, according to the idea of the present invention, the specific embodiments and the application range may be changed. In view of the above, the present disclosure should not be construed as limiting the invention.

Claims (8)

Translated fromChinese

1.一种非密闭性球囊的冲击波导管，其特征在于：包括1. A shock wave guide of a non-hermetic balloon, characterized in that: comprising:导管，所述导管具有轴向的管线和贯穿所述导管的导引线内腔；a catheter having an axial line and a guide wire lumen extending through the catheter;球囊，所述导管贯穿所述球囊，所述球囊的两端与所述导管密封设置，所述球囊携带有药物，所述球囊上设置有微孔，所述球囊能通过介质充胀；A balloon, the catheter runs through the balloon, the two ends of the balloon are sealed with the catheter, the balloon carries medicine, and the balloon is provided with micro holes, and the balloon can pass through media inflation;冲击波电极，所述导管承载并被封装在所述球囊内有多个所述冲击波电极，所述冲击波电极沿所述导管的轴向布置并且能够产生经所述介质传播的冲击波。A shock wave electrode, the catheter carries and is packaged in the balloon with a plurality of the shock wave electrodes arranged along the axial direction of the catheter and capable of generating shock waves propagating through the medium.2.根据权利要求1所述的非密闭性球囊的冲击波导管，其特征在于：所述球囊为多层囊腔结构，每层囊腔上均设置有所述微孔，且每层囊腔分别与所述导管内的管线连通。2 . The shock wave catheter of a non-hermetic balloon according to claim 1 , wherein the balloon is a multi-layered cavity structure, each layer of the cavity is provided with the micropores, and each layer of the capsule is provided with the micropores. 3 . The lumens are in communication with lines within the conduits, respectively.3.根据权利要求2所述的非密闭性球囊的冲击波导管，其特征在于：所述球囊为两层囊腔结构，每层囊腔上的所述微孔交错布置。3 . The shock wave catheter of a non-hermetic balloon according to claim 2 , wherein the balloon is a two-layered cavity structure, and the micropores on each layer of the cavity are arranged in a staggered manner. 4 .4.根据权利要求1所述的非密闭性球囊的冲击波导管，其特征在于：所述球囊的材质为医用尼龙，所述微孔均布于每层囊腔的表面上且直径为1um-50um。4 . The shock wave catheter of claim 1 , wherein the balloon is made of medical nylon, and the micropores are uniformly distributed on the surface of each layer of the cavity and have a diameter of 1 μm. 5 . -50um.5.一种采用权利要求1-4中任意一项所述的非密闭性球囊的冲击波导管的定向送药方法，其特征在于：至少包括如下步骤：先将非封闭式球囊引导至患者血管的病灶处，通过导管内的管路将生理盐水、显影液和药液导入球囊中，控制冲击波发生器释放冲击波，冲击波治疗过程中，所述药液撑开所述球囊上的微孔流出所述所述球囊，直达所述病灶处。5. A method for directional drug delivery using a shock wave catheter of a non-sealed balloon according to any one of claims 1-4, characterized in that: it at least comprises the following steps: firstly guiding the non-sealed balloon to the patient At the lesion of the blood vessel, the physiological saline, the developing solution and the medicinal solution are introduced into the balloon through the pipeline in the catheter, and the shock wave generator is controlled to release the shock wave. The hole flows out of the balloon to the lesion.6.根据权利要求5所述的非密闭性球囊的冲击波导管的定向送药方法，其特征在于：先将所述生理盐水和所述显影液以第一设定压强导入所述球囊中，冲击波治疗后，再通过所述导管将药液导入球囊中，并通过所述药液使所述球囊增大至第二设定压强，撑开所述球囊上的微孔。6 . The directional drug delivery method for a shock wave catheter of a non-hermetic balloon according to claim 5 , wherein the physiological saline and the developing solution are firstly introduced into the balloon at a first set pressure. 7 . , after the shock wave treatment, the medicinal liquid is introduced into the balloon through the catheter, and the medicinal liquid is used to increase the balloon to a second set pressure to open the micropores on the balloon.7.根据权利要求6所述的非密闭性球囊的冲击波导管的定向送药方法，其特征在于：所述第一设定压强为1MPa-4MPa，所述第二设定压强为5MPa-10MPa。7 . The directional drug delivery method for a shock wave catheter of a non-hermetic balloon according to claim 6 , wherein the first set pressure is 1 MPa-4 MPa, and the second set pressure is 5 MPa-10 MPa. 8 . .8.根据权利要求5所述的非密闭性球囊的冲击波导管的定向送药方法，其特征在于：所述球囊为两层囊腔结构，外层囊腔用于容纳治疗用的药液，内层囊腔用于容纳生理盐水和显影液。8 . The directional drug delivery method for a shock wave catheter of a non-hermetic balloon according to claim 5 , wherein the balloon is a two-layer cavity structure, and the outer cavity is used to accommodate the medicinal liquid for treatment. 9 . , the inner layer of the capsule is used to accommodate normal saline and developing solution.

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