Disclosure of Invention
Aiming at the problems in the prior art, the invention provides a multichannel electro-spasmodic treatment device, a multichannel electro-spasmodic treatment system and a multichannel electro-spasmodic treatment server, which have the advantages of simple structure, accurate quantification and low occurrence probability of side effects.
The invention is realized by the following technical scheme:
a multi-channel electro-spasmodic treatment device comprising,
The image acquisition module is used for acquiring brain images of the patient;
the image segmentation module is used for segmenting the brain image according to different physiological tissues;
the image reconstruction module is used for constructing an electrical model of the brain anatomy structure according to the electrical parameters corresponding to the physiological tissue from the segmented brain image;
the finite element simulation module is used for carrying out finite element simulation calculation on the stimulation parameters of the body surface stimulation channel based on the electrical model of the anatomical structure under the condition of meeting the stimulation on the threshold of the brain target area;
the parameter optimization module is used for optimizing the stimulation parameters obtained by the simulation calculation to obtain minimum stimulation current parameters;
And the stimulation electrode module is used for generating corresponding electric spasm stimulation according to the received minimum stimulation current parameters respectively.
Optionally, the image segmentation module is specifically configured to segment the brain image into skull, grey brain matter, white brain matter and cerebrospinal fluid according to physiological tissue;
the image reconstruction module is specifically used for constructing an electrical model of a brain anatomical structure according to electrical parameters corresponding to physiological tissue skull, brain gray matter, brain white matter and cerebrospinal fluid, wherein the electrical parameters are relative dielectric constant and electrical conductivity.
Optionally, the device further comprises a driving unit for driving the electrodes, wherein the driving unit drives the plurality of stimulation electrodes according to the number of stimulation channels and the stimulation current intensity in the received minimum stimulation current parameter.
Optionally, the system further comprises a vital sign monitoring module, which is used for receiving the photoelectric volume wave signal and the brain electrical signal of the patient, extracting the physiological indexes in the photoelectric volume wave signal and the brain electrical signal and monitoring.
Optionally, the device further comprises a data acquisition module for acquiring photoelectric volume wave signals and brain electrical signals of the patient and transmitting the photoelectric volume wave signals and the brain electrical signals to the vital sign monitoring module.
A multi-channel electro-spasmodic treatment system comprising,
The imaging equipment is used for acquiring brain images of the patient;
the system comprises a server, a finite element simulation calculation device, a minimum stimulation current parameter, a simulation calculation device and a simulation calculation device, wherein the server is used for dividing brain images of different patients according to physiological tissue types, the electric model is used for constructing brain anatomy structures according to electric parameters corresponding to the physiological tissue from the divided brain images, the finite element simulation calculation device is used for carrying out finite element simulation calculation on stimulation parameters of a body surface stimulation channel based on the electric model under the condition of meeting stimulation on a target area of the brain, the minimum stimulation current parameter is obtained by optimizing the stimulation parameters obtained by simulation calculation, and the minimum stimulation current parameter is sent to different user ends;
and the user side is used for receiving the minimum stimulation current parameters which are sent by the server and matched with the user side of the patient, and generating corresponding electric spasm stimulation through a plurality of stimulation electrodes of the user side according to the received minimum stimulation current parameters.
Optionally, the user terminal further includes a data acquisition unit, configured to receive the photoelectric volume wave signal of the patient acquired by the photoelectric volume waveguide, configured to receive the electroencephalogram signal of the patient acquired by the electroencephalogram waveguide, and configured to transmit the received photoelectric volume wave signal and the electroencephalogram signal to the server.
Optionally, the system further comprises a vital sign monitoring device, which is used for receiving the photoelectric volume wave signal and the brain electrical signal sent by the user side and extracting physiological indexes in the photoelectric volume wave signal and the brain electrical signal for monitoring.
A multi-channel electro-spasticity treatment server comprising a memory and a processor, said memory having stored thereon a computer program capable of running on said processor, said processor implementing the steps of when executing said computer program,
Acquiring brain images of a patient;
dividing the brain image according to physiological tissues;
constructing an electrical model of brain anatomy structure according to the electrical parameters corresponding to the physiological tissue from the segmented brain image;
Under the condition of meeting the stimulation on the threshold of the target area of the brain, carrying out finite element simulation calculation on the stimulation parameters of the body surface stimulation channel based on the electrical model of the anatomical structure;
optimizing the simulation parameters obtained by simulation calculation to obtain minimum stimulation current parameters;
And sending the minimum stimulation current parameters to the stimulation electrodes corresponding to the plurality of user terminals, wherein the stimulation electrodes used for the plurality of user terminals respectively generate corresponding electric spasm stimulation.
A multi-channel electro-spasticity treatment computer readable storage medium having stored thereon a computer program, which when executed by the processor performs the steps of,
Acquiring brain images of a patient;
dividing the brain image according to physiological tissues;
constructing an electrical model of brain anatomy structure according to the electrical parameters corresponding to the physiological tissue from the segmented brain image;
Under the condition of meeting the stimulation on the threshold of the target area of the brain, carrying out finite element simulation calculation on the stimulation parameters of the body surface stimulation channel based on the anatomical structure electrical model;
optimizing the simulation parameters obtained by simulation calculation to obtain minimum stimulation current parameters;
and sending the minimum stimulation current parameters to the stimulation electrodes corresponding to the plurality of user terminals, wherein the stimulation electrodes used for the plurality of user terminals respectively generate corresponding electric spasm stimulation.
Compared with the prior art, the invention has the following beneficial technical effects:
The invention establishes an electrical model based on the individual image of the patient, can accurately calculate the minimum stimulation current applied by each stimulation channel of the body surface when the stimulation is caused on the threshold of the target region through simulation, realizes the transition from extensive experience stimulation to accurate quantitative stimulation, reduces the tissue activation volume of the stimulation path on the premise of not affecting the effect by replacing the traditional single-channel stimulation with the multi-channel electric spasmodic stimulation of the body surface, and reduces the possibility of occurrence of cognitive side effects.
Furthermore, the photoelectric volume wave signals with simple and high cost performance are used for physiological monitoring, so that the complexity and the cost of the system are effectively reduced, and the reliability of the system is improved.
Detailed Description
The invention will now be described in further detail with reference to specific examples, which are intended to illustrate, but not to limit, the invention.
For the purpose of making the objects, technical solutions and advantages of the embodiments of the present invention more apparent, the technical solutions of the embodiments of the present invention will be clearly and completely described below with reference to the accompanying drawings in the embodiments of the present invention, and it is apparent that the described embodiments are some embodiments of the present invention, but not all embodiments of the present invention. All other embodiments, which can be made by those skilled in the art based on the embodiments of the invention without making any inventive effort, are intended to be within the scope of the invention.
It should be noted that, without conflict, the embodiments of the present application and features of the embodiments may be combined with each other.
The invention may be described in the general context of computer-executable instructions, such as program modules, being executed by a computer. Generally, program modules include routines, programs, objects, components, data structures, etc. that perform particular tasks or implement particular abstract data types. The invention may also be practiced in distributed computing environments where tasks are performed by remote processing devices that are linked through a communications network. In a distributed computing environment, program modules may be located in both local and remote computer storage media including memory storage devices.
In the present invention, "module," "device," "system," and the like refer to a related entity, either hardware, a combination of hardware and software, or software in execution, as applied to a computer. In particular, for example, an element may be, but is not limited to being, a process running on a processor, an object, an executable, a thread of execution, a program, and/or a computer. Also, the application or script running on the server, the server may be an element. One or more elements may be in processes and/or threads of execution, and elements may be localized on one computer and/or distributed between two or more computers, and may be run by various computer readable media. The elements may also communicate by way of local and/or remote processes in accordance with a signal having one or more data packets, e.g., a signal from one data packet interacting with another element in a local system, distributed system, and/or across a network of the internet with other systems by way of the signal.
Finally, it is further noted that relational terms such as first and second, and the like are used solely to distinguish one entity or action from another entity or action without necessarily requiring or implying any actual such relationship or order between such entities or actions. Moreover, the terms "comprises," comprising, "or" includes not only those elements but also other elements not expressly listed or inherent to such process, method, article, or apparatus. Without further limitation, an element defined by the phrase "comprising" does not exclude the presence of additional identical elements in a process, method, article, or apparatus that comprises the element.
Example 1
Aiming at the problems that the existing single-channel electro-spasmodic treatment device and method selected based on experience values are unclear in mechanism elucidation of the treatment method, the single-channel electro-spasmodic treatment body surface stimulation current is large, and the risk of cognitive side effects can be caused, the invention provides a multi-channel electro-spasmodic treatment device, as shown in figure 1, which comprises,
The image acquisition module 101 is configured to acquire a brain image of a patient, and send the acquired anatomical image to the image segmentation module 102 for processing.
The brain image of the patient is a brain magnetic resonance image of the patient, and in general, there are many magnetic resonance sequences capable of distinguishing gray matter, white matter and cerebrospinal fluid tissue components, such as conventional skull T1, T2 sequences and T2 FLAIR sequences, which can provide a single frame of 512 x 512 pixels high resolution image, but the sequences generally do not acquire complete skull images, so that a complete skull geometry and physical model cannot be established during modeling; according to the invention, a single-frame 256-pixel OAx DWI Asset axial position diffusion weighted imaging sequence for acquiring the complete cranium image is selected, and in fact, the calculation accuracy of 256-pixel can completely distinguish skull, cerebrospinal fluid, gray matter and white matter, and the requirement of physical modeling can be met.
The image segmentation module 102 is used for segmenting the target brain image according to physiological tissues;
Generating four physiological tissues divided into skull, grey brain matter, white brain matter and cerebrospinal fluid according to the brain magnetic resonance image of the patient;
the image reconstruction module 103 is configured to construct an electrical model of the brain anatomy structure according to the electrical parameters corresponding to the physiological tissue from the segmented brain image;
Wherein the electrical parameters are relative permittivity and conductivity.
The multi-physical-field simulation module 104 is used for performing finite element simulation calculation on the stimulation parameters of the body surface stimulation channel based on the anatomical structure electrical model under the condition of meeting the stimulation on the threshold of the brain target area;
When multi-physical field simulation calculation is performed, performing multi-physical field simulation by using a finite element model;
the essence of the calculation of the distribution of the electric field of the cranium part under the condition of external electric stimulation is to solve maxwell's equations in a medium formed by various biological tissues. Namely:
·D=ρ
·B=0
Meanwhile, in each tissue medium, the constitutive relation of the tissue medium must be satisfied between the field amounts, that is, in a uniform, isotropic medium:
D=εE;
B=μH;
J=σE
Thereby obtaining a defined form of maxwell's equations:
·(εE)=ρ
·(μH)=0
where ρ is the charge density (C/m3) and ε is the dielectric constant, μ is the permeability, σ is the conductivity (S/m), and in a non-uniform medium, the boundary value relationship of the electromagnetic field at the interface is also considered, and the electromagnetic field value at any point in space and any time is solved by using the initial condition of the field quantity at t=0.
The parameter optimization module 105 is used for optimizing the stimulation parameters obtained by the simulation calculation to obtain minimum stimulation current parameters;
The method comprises the steps of firstly calculating the stimulation current in a target area of a deep brain nucleus (hippocampus, amygdala area) when the stimulation current of the surface of the brain is given, setting the stimulation current of the surface of the brain to change from 0mA to 400mA, taking 10mA as a stepping value, calculating the surface current density in the target area of the corresponding deep brain nucleus (hippocampus, amygdala area) when the stimulation current is set once, calculating the size of the cross section according to the radius of the cross section of the nucleus, and further obtaining and recording the stimulation current passing through the cross section. When the stimulating current on the surface of a certain cranium is determined to induce epileptic seizure of the nuclear tissue, the stimulating current on the surface of the cranium is used as a range of +/-5 mA, 1mA is used as a stepping value, and the size of the stimulating current passing through the cross section of the nuclear corresponding to the set stimulating current value is recalculated, so that the minimum stimulating current on the surface of the cranium exceeding the threshold value of the epileptic seizure of the nuclear is obtained with the accuracy of 1 mA.
The stimulating electrode module 106 is configured to generate corresponding electrical spasm stimulation according to the received minimum stimulation current parameters, respectively.
The device is provided with a plurality of independent stimulation channels, 3 are taken as an example for illustration in the preferred example, a plurality of optimized lower minimum stimulation currents are applied to the surface of the cranium through different stimulation channels at different positions, meanwhile, the stimulation channels act on the target area of the brain, and the upper threshold electric stimulation is formed by overlapping the target area, so that the device for directly forming the upper threshold electric stimulation on the target area by applying a single stronger current stimulation channel only at the same position is replaced, the stimulation current flowing through each stimulation channel is reduced on the basis of maintaining the original stimulation effect, and the aim of reducing the cognitive side effect is fulfilled. In particular use, as shown in fig. 4, the first pair of stimulating electrodes are located in the temple on either side of the temporal lobe, the second pair of electrodes are located in the five acupoints on either side of the bregma, and the third pair of additional electrodes are located in the collateral acupoints near the posterior fontanel.
The invention does not select the stimulation current based on experience, but establishes an electrical model based on the brain magnetic resonance image of the patient individual, accurately calculates the minimum damage stimulation current applied by each stimulation channel of the body surface when the target area of the amygdala of the brain is stimulated, realizes the transition from extensive experience therapy to accurate quantitative therapy, and simultaneously superimposes the stimulation of the surface multichannel electric spasticity on the target area of the amygdala of the brain to form the upper threshold stimulation, replaces the traditional single-channel electric spasticity to directly apply the upper threshold stimulation of the target area, and is shown in figure 5, and the current density distribution generated by different stimulation channel numbers during the multichannel electric spasticity treatment. Obviously, when the amygdala reaches the stimulation threshold, the stimulation current per stimulation channel is reduced along with the increase of the number of channels, so that the stimulation current per channel is 191.38 +/-64.79 mA in a single channel to 163.16 +/-55.87 mA in a double channel in the preferred example, the stimulation current per channel is 146.73 +/-51.97 mA in a three-channel state, and the three are obviously different (p is less than or equal to 0.0001), although the sum of the stimulation currents per channel is possibly higher than that of the single channel, the current on each stimulation path is obviously lower than that of the single channel, the tissue activation volume of the stimulation path is reduced, and the possibility of occurrence of cognitive side effects is reduced on the premise of not affecting the treatment effect.
Example 2
On the basis of the embodiment 1, the invention further comprises a vital sign monitoring module which is used for receiving the photoelectric volume wave signal and the brain electrical signal of the patient, extracting the physiological indexes in the photoelectric volume wave signal and the brain electrical signal and monitoring. So that the vital signs of the patient are monitored in actual use.
When the device is used, the photoelectric volume wave amplifier and the photoelectric volume wave and the electroencephalogram signal detected by the electroencephalogram amplifier are received before three independent stimulation channels are respectively driven to form multichannel electric spasticity stimulation, so that vital sign monitoring is performed. In a preferred embodiment of the present invention, the patient monitoring system further comprises a data acquisition module for acquiring the photoelectric volume wave signal and the brain electrical signal of the patient and transmitting the signals to the vital sign monitoring module. The monitoring function of the device is realized through the complete flow of data acquisition, transmission and display.
Example 3
Aiming at the current situation that monitoring equipment in operation is complex and impractical in actual conditions, the electric spasm treatment device is often abandoned in actual treatment, has large volume and complex power supply, and is difficult to leave a physical treatment operating room for use. In yet another embodiment of the present invention, a multi-channel electro-spasticity treatment system is provided, as shown in fig. 2, comprising,
An image acquisition module 201, configured to acquire a brain image of a patient;
The system comprises a server 202, a multi-physical-field simulation calculation, a minimum stimulation current parameter, a plurality of user terminals, a simulation calculation module and a simulation calculation module, wherein the server 202 is used for dividing a brain image of a patient according to physiological tissues, constructing an electrical model of a brain anatomical structure according to electrical parameters corresponding to the physiological tissues, performing multi-physical-field simulation calculation on the stimulation parameters of a body surface stimulation channel based on the electrical structure model under the condition of meeting stimulation on a target region of the brain, and optimizing the stimulation parameters obtained by the simulation calculation to obtain the minimum stimulation current parameter;
the user terminal 203 is configured to receive the minimum stimulation current parameter sent by the server and matched with the user terminal of the patient, and generate corresponding electro-spasmodic stimulation through a plurality of stimulation electrodes of the user terminal according to the received minimum stimulation current parameter.
The server is actually integrated with an image acquisition module 101, an image segmentation module 102, an image reconstruction module 103, a multi-physical-field simulation module 104 and a parameter optimization module 105 in the device, and is placed in a large and medium-sized mental health center physical therapy department, the image acquisition module 201 is respectively dispersed in an image center of a medical and health institution, so that the separation of each part of the system is realized, communication equipment such as a smart phone and a tablet personal computer can be used as a separation platform, parameters optimized in advance are stored in the separation platform, and only the separation platform and a matched user terminal 203 are carried as a stimulation device to enter a community, and the family dispersedly develops follow-up electric spasm therapy for patients inconvenient for admission therapy.
Meanwhile, the user terminal further comprises a data acquisition unit for receiving the photoelectric volume wave signals of the patient acquired by the photoelectric volume wave connection, for receiving the brain electrical signals of the patient acquired by the brain electrical connection, and for transmitting the received photoelectric volume wave signals and brain electrical signals to the server. And the vital sign monitoring device is used for receiving the photoelectric volume wave signals and the brain electrical signals sent by the user side and extracting physiological indexes in the photoelectric volume wave signals and the brain electrical signals for monitoring. The part and the user terminal 203 are together capable of realizing separation and portable carrying and use with other two parts, the photoelectric volume wave amplifier and the electroencephalogram amplifier collect finger-end or wrist photoelectric volume waves through photoelectric volume wave coupling respectively, and collect electroencephalogram signals through electroencephalogram electric coupling, and simultaneously monitor physiological parameters such as pulse rate, respiration, blood oxygen saturation, heart rate variability and the like and the multichannel electric spasm treatment effect, and provide data for vital sign monitoring in a patient operation.
In this embodiment, the number of the user terminals 203 may be three or more, which can rely on the existing internet or the internet of things, and uses one server 202 as a core, and the plurality of acquisition modules 201 are utilized to acquire patient data, and then the corresponding user terminals 203 monitor and treat a plurality of patients at the same time, so that the flexibility and adaptability of the system are greatly improved.
Example 4
If the system of the present invention is used in only one treatment room, the server of the system can be actually replaced by a host computer, and in particular, as shown in fig. 3.
The multichannel electro-spasticity treatment device comprises the following components:
And the component 01 is an upper computer. The upper computer comprises components 21-25, wherein,
Component 21, image divider. Generating different tissue images which are divided into four physiological tissues of skull, grey matter of brain, white matter of brain, cerebrospinal fluid and the like according to a craniocerebral magnetic resonance image carried out before operation of a patient, wherein the component 21 affects a divider, and a 1.5T or 3.0T OAx DWI Asset axial position dispersion weighted imaging sequence magnetic resonance image carried out before operation of the patient is used;
component 22, image reconstructor. Reconstructing a craniocerebral electrical structure model according to electrical parameters, in particular relative permittivity and conductivity, of different tissues such as skull, grey matter, white matter, cerebrospinal fluid and the like;
The relative dielectric constants and the conductivities of the component 22 in the imaging process of the imaging reconstructor are obtained through actual measurement or experience, wherein the relative dielectric constants of skull, brain gray matter, brain white matter and cerebrospinal fluid are 217030, 3906100, 1667700 and 109 respectively, and the conductivities (S/m) are 0.0810, 2, 0.08918 and 0.058093 respectively.
Component 23, multiple physical field simulator. Performing multi-physical-field simulation by using a finite element model, and performing simulation calculation on stimulation parameters such as stimulation current of a body surface stimulation channel under the condition of meeting the stimulation on the threshold of a target region of the brain;
wherein the component 23 comprises a multiple physical field simulator, and wherein the threshold for supranuclear stimulation at the amygdala is calculated to be about 500uA, as measured or empirically obtained, when the supranuclear stimulation is generated at the amygdala at the craniocerebral target.
Component 24 parameter optimizer. The calculation and optimization of the stimulation parameters are completed, the stimulation parameters such as the number of stimulation channels, the stimulation current intensity and the like are optimized, the minimum damage stimulation parameters are generated, and then the minimum damage stimulation parameters are transmitted to the component 02 data acquisition card in a wired or wireless mode;
component 25 vital sign monitor. Displaying the brain electrical signals and the photoelectric volume wave signals acquired by the component 02 data acquisition card on a monitoring screen in a wired or wireless mode, and extracting physiological indexes such as heart rate, respiration, blood oxygen saturation, heart rate variability and the like from the brain electrical signals and the photoelectric volume wave signals for intraoperative monitoring of vital signs of a patient;
Component 02, data acquisition card. And simultaneously, a vital sign monitor in the upper computer displays the brain electrical signals and the photoelectric volume wave signals acquired by the component 02 data acquisition card on a monitoring screen in a wired or wireless mode, and extracts physiological indexes such as heart rate, respiration, blood oxygen saturation, heart rate variability and the like in the brain electrical signals and the photoelectric volume wave signals for monitoring vital signs of patients in operation. Specifically, the optimal minimum damage current stimulation parameters transmitted by the upper computer of the component 01 are received in a wired or wireless mode, and three independent stimulation channels of the components 06, 07 and 08 are respectively driven to form multichannel electric spasm stimulation;
component 03, high energy density lithium ion battery. Providing power supply for other components except the upper computer of the component 01, and particularly providing corresponding energy supply for the stimulation output of three stimulation channels of the components 06, 07 and 08;
assembly 04, photo-voltaic bulk wave amplifier. Collecting finger tip or wrist photoelectric volume wave through the photoelectric volume waveguide coupling of the component 09, simultaneously monitoring physiological parameters such as pulse rate, respiration, blood oxygen saturation, heart rate variability and the like, sending the physiological parameters to the data acquisition card of the component 02 and sending the physiological parameters back to the upper computer of the component 01, and providing data for vital sign monitoring in the operation of a patient;
And the component 05 is an electroencephalogram amplifier. The brain electrical signal is collected through the 10 brain electrical leads of the component, and the multi-channel electric spasm treatment effect is monitored. Monitoring whether the epileptic electroencephalogram is induced after stimulation, and judging whether the electric stimulation is effective by taking the epileptic electroencephalogram as an indication;
the components 06, 07 and 08 are three completely same and mutually independent stimulation channels, are used for receiving output signals of the data acquisition card, generating electric spasm stimulation, respectively transmitting the electric spasm stimulation to the stimulation electrodes 1,2 and 3 of the components 11, 12 and 13, respectively, sending low-intensity minimum stimulation current to the cranium of a patient, and superposing and combining the target areas to generate suprathreshold stimulation to induce epileptic electroencephalogram attacks so as to achieve the treatment purpose;
assembly 09 photo-voltaic volumetric waveguide coupling. The photoelectric volume wave amplifier is used for transmitting finger tip or wrist photoelectric volume wave signals to the photoelectric volume wave amplifier of the component 04 so as to extract physiological information such as pulse rate, respiration, blood oxygen saturation, heart rate variability and the like in the photoelectric volume wave;
Assembly 10. Brain electrical leads. The brain electrical signal detection module is used for detecting brain electrical signals of a patient and transmitting the brain electrical signals to the assembly 05 brain electrical amplifier so as to detect whether epileptic discharge exists in brain electrical signals;
The photoelectric volume wave amplifier 04 and the electroencephalogram amplifier 05 collect finger-end or wrist photoelectric volume waves through the photoelectric volume waveguide connection 09 respectively, collect electroencephalogram signals through the electroencephalogram connection 10, monitor physiological parameters such as pulse rate, respiration, blood oxygen saturation, heart rate variability and the like and the multi-channel electric spasm treatment effect simultaneously, and provide data for vital sign monitoring in a patient operation.
The components 11, 12 and 13 are 3 identical and mutually independent stimulating electrodes. The stimulation current generated by the three stimulation channels of the components 06, 07 and 08 is delivered and issued to the cranium of the patient to complete the treatment process;
According to the device, the upper computer is used for completing the calculation and optimization of the stimulation parameters, the traditional complex and expensive ECG (electro magnetic resonance) and EMG (electro magnetic resonance) sensing amplifier is not used for carrying out intraoperative monitoring, but a photoelectric volume wave sensing amplifier with a simple and compact structure and high cost performance is used for carrying out MECT intraoperative monitoring in cooperation with the EEG amplifier, so that the number of monitored physiological parameters is increased, the complexity and the cost of a system are effectively reduced, and the reliability of the system is improved;
The invention adopts a high-energy density lithium battery power supply mode instead of a traditional alternating current mains supply mode, so that the traditional single-channel electric spasticity therapy which is required to be completed in a physical therapy operating room is evolved into community treatment activities which can be developed everywhere in families and communities, the applicable treatment space and the application range are expanded, and the treatment coverage rate of mental diseases can be effectively improved.
In the preferred embodiment, the components 21-25 in the upper computer are integrated, namely, the image divider, the image reconstructor, the multi-physical-field simulator, the parameter optimizer and the vital sign monitor are integrated into a whole, and the upper computer is suitable for centralized use in the physical therapy department of large and medium-sized mental health centers, and one upper computer can be provided with a plurality of sets of stimulation devices to synchronously carry out treatment work.
Example 5
The present invention also provides, on the basis of example 3, a server comprising a memory and a processor, said memory having stored thereon a computer program capable of running on said processor, said processor implementing the steps of,
Acquiring brain images of a patient;
dividing the brain image according to physiological tissues;
Constructing an electrical model of a brain anatomical structure according to electrical parameters corresponding to physiological tissues from the segmented brain images;
Under the condition of meeting the stimulation on the threshold of the target area of the brain, carrying out multi-physical-field simulation calculation on the stimulation parameters of the body surface stimulation channel based on the electrical model of the anatomical structure;
optimizing the simulation parameters obtained by simulation calculation to obtain minimum stimulation current parameters;
And sending the minimum stimulation current parameter to a plurality of stimulation electrodes for respectively generating corresponding electric spasm stimulation by the plurality of stimulation electrodes.
Example 6
The present invention further comprises a computer readable storage medium having a computer program stored thereon, which when executed by the processor performs the steps of,
Acquiring brain images of a patient;
dividing the brain image according to physiological tissues;
Constructing an electrical model of a brain anatomical structure according to electrical parameters corresponding to physiological tissues from the segmented brain images;
Under the condition of meeting the stimulation on the threshold of the target area of the brain, carrying out finite element simulation calculation on the stimulation parameters of the body surface stimulation channel based on the anatomical structure electrical model;
optimizing the simulation parameters obtained by simulation calculation to obtain minimum stimulation current parameters;
And sending the minimum stimulation current parameter to a plurality of stimulation electrodes for respectively generating corresponding electric spasm stimulation by the plurality of stimulation electrodes.
It will be appreciated by those skilled in the art that embodiments of the present invention may be provided as a method, system, or computer program product. Accordingly, the present invention may take the form of an entirely hardware embodiment, an entirely software embodiment or an embodiment combining software and hardware aspects. Furthermore, the present invention may take the form of a computer program product embodied on one or more computer-usable storage media (including, but not limited to, disk storage, CD-ROM, optical storage, and the like) having computer-usable program code embodied therein.
The present invention is described with reference to flowchart illustrations and/or block diagrams of methods, apparatus (systems) and computer program products according to embodiments of the invention. It will be understood that each flow and/or block of the flowchart illustrations and/or block diagrams, and combinations of flows and/or blocks in the flowchart illustrations and/or block diagrams, can be implemented by computer program instructions. These computer program instructions may be provided to a processor of a general purpose computer, special purpose computer, embedded processor, or other programmable data processing apparatus to produce a machine, such that the instructions, which execute via the processor of the computer or other programmable data processing apparatus, create means for implementing the functions specified in the flowchart flow or flows and/or block diagram block or blocks.
These computer program instructions may also be stored in a computer-readable memory that can direct a computer or other programmable data processing apparatus to function in a particular manner, such that the instructions stored in the computer-readable memory produce an article of manufacture including instruction means which implement the function specified in the flowchart flow or flows and/or block diagram block or blocks.
These computer program instructions may also be loaded onto a computer or other programmable data processing apparatus to cause a series of operational steps to be performed on the computer or other programmable apparatus to produce a computer implemented process such that the instructions which execute on the computer or other programmable apparatus provide steps for implementing the functions specified in the flowchart flow or flows and/or block diagram block or blocks.
Finally, it should be noted that the above embodiments are only for illustrating the technical solution of the present invention and not for limiting the same, and although the present invention has been described in detail with reference to the above embodiments, it should be understood by those skilled in the art that modifications and equivalents may be made to the specific embodiments of the present invention without departing from the spirit and scope of the present invention, and any modifications and equivalents are intended to be included in the scope of the claims of the present invention.