CN113577535A - Novel electrode array for electric field treatment of tumors - Google Patents

Abstract

The invention relates to a novel electrode array for electric field treatment of tumors, comprising: the flexible substrate is provided with an electric field generating area, a flexible positioning component is arranged in the electric field generating area, a plurality of ceramic electrode plates are arranged on the flexible positioning component in an array mode, and the electrode plates are connected through a flexible circuit board; the flexible positioning component is provided with a plurality of positioning holes, the electrode plate is arranged in the positioning holes, and the diameter of the electrode plate is 3-15 mm. The electrode array device has the advantages that the electrode arrays can be arranged in the electric field generation area in an array mode through the small-size electrode plates, the energy density is improved, the electric field intensity of a patient treatment position is remarkably improved compared with the electric field intensity of the patient treatment position in the prior art, the flexibility is good, and the electrode arrays can be tightly attached to the skin of different parts of the patient.

Description

Novel electrode array for electric field treatment of tumors

Technical Field

The invention relates to the technical field of medical instruments, in particular to a novel electrode array for treating tumors by an electric field.

Background

Brain gliomas are malignant tumors derived from neuroepithelial tissues, commonly known as "brain cancers". Brain glioma is the most common intracranial primary tumor, and foreign clinical statistics show that the incidence rate of intracranial primary tumors is 21/10 ten thousand, and glioma accounts for about 60%. Domestic literature reports that brain glioma accounts for about 35.26% -60.96% of intracranial tumors. The most common treatment method at present is surgery and radiotherapy and chemotherapy, and the brain glioma grows infiltratively, so the surgery is often difficult to completely cut. And because the tumor is a radiation-resistant tumor and is resistant to most chemotherapeutics, the overall curative effect is poor, especially high-grade glioma has the growth characteristic of high gradual change, the postoperative recurrence is fast, the prognosis is poor, and the health of human beings is seriously threatened. Tumor treating electric fields (tumor treating fields) have a good effect on tumor treatment by interfering with the mitotic process of destroying cells.

Referring to fig. 1, the electrode array for the existing therapeutic electric field mostly adopts 9electrode slices 100 in the prior art arranged in a structure like the Chinese character 'wang', and the structural design has the following problems: 1. electrode coating is large (about 7700 mm)²And the occupied area of 9 electrodes is 22.5cm²) The area of the single electrode plate is 2500mm²The electrodes are sparsely distributed, and the energy density is low (the capacitance range of the single-chip electrode plate is about 20 nF). 2. The electrode slice is large in size (the diameter is 19 mm), and the head is circular, so that local tilting is easy to occur in the wearing process, and the electrode slice cannot be in good contact with the head. 3. The single electrode plate is large, the thickness is about 1mm, the long-term wearing comfort of a patient is poor, and the scalp has obvious indentation.

Disclosure of Invention

The technical problem to be solved by the invention is to provide a novel electrode array for electric field treatment of tumors, wherein a plurality of small-sized electrode plates are arranged in an array manner in an electric field generation area, so that the energy density is improved, the electric field intensity of a patient treatment position is obviously improved compared with that of the prior art, the flexibility is good, and the novel electrode array can be tightly attached to the skin of different parts of the patient, so that the problems in the background art are solved.

In order to solve the problems, the technical scheme adopted by the invention is as follows:

a novel electrode array for electric field treatment of tumors, comprising: the flexible substrate is provided with an electric field generating area, a flexible positioning component is arranged in the electric field generating area, a plurality of ceramic electrode plates are arranged on the flexible positioning component in an array mode, and the electrode plates are connected through a flexible circuit board; the flexible positioning component is provided with a plurality of positioning holes, and the electrode plate is arranged in the positioning holes;

the diameter of the electrode plate is 3-15 mm.

As a further improvement of the invention, the diameter of the electrode plate is 5-10 mm.

As a further improvement of the invention, a plurality of electrode plates are arranged in a staggered manner.

As a further improvement of the invention, the flexible positioning part is a whole rectangular flexible positioning sheet or a plurality of flexible positioning sheets arranged in an array.

As a further improvement of the invention, the flexible positioning component comprises a plurality of flexible positioning sheets which are arranged in rows, a plurality of positioning holes on two adjacent rows of the flexible positioning sheets are arranged in a staggered manner, and abdicating grooves are arranged on two sides of each flexible positioning sheet and between every two adjacent positioning holes.

As a further improvement of the present invention, a containing groove is provided in the flexible positioning sheet corresponding to the flexible circuit board for placing and fixing the flexible circuit board.

As a further improvement of the invention, the thickness of the electrode plate is 0.3-0.7 mm.

As a further improvement of the invention, the upper surface of the electrode plate is higher than the upper surface of the flexible positioning component.

As a further improvement of the invention, the flexible circuit board is connected with a power supply device through an external lead, and a sleeve made of rubber is arranged at the joint of the external lead and the flexible circuit board.

As a further improvement of the present invention, 54 pieces of the electrode plates are arranged in the electric field generation region in a staggered manner, and the 54 pieces of the electrode plates are arranged in a staggered manner in a manner that the width x the height is 6 x 9;

the diameter of each electrode plate is 10mm, and the thickness of each electrode plate is 0.3 mm.

Adopt the produced beneficial effect of above-mentioned technical scheme to lie in:

the electrode slice of this application be a small-size electrode slice, through the fixed setting on flexible base member of the locating hole that the array set up on the flexible locating component, there is the clearance between two adjacent electrode slices of upper and lower two rows, makes the electrode array paster of this application when possessing the energy of high density, makes electrode array have nimble ability of buckling through small-size electrode slice, can be inseparabler when the treatment patient laminating on patient skin surface. This application is through adopting small-size electrode slice, increases the total area of electrode slice upper surface under the condition of the same electric field emergence district area, has both increased holistic capacitance value, has the size that has reduced the pressure that patient skin surface received, and further increase patient's treatment experience.

Drawings

In order to more clearly illustrate the embodiments of the present invention or the technical solutions in the prior art, the drawings used in the description of the embodiments or the prior art will be briefly described below, and it is obvious that the drawings in the following description are some embodiments of the present invention, and other drawings can be obtained by those skilled in the art without creative efforts.

FIG. 1 is a schematic diagram of a prior art electrode array.

FIG. 2 is a front view showing a flexible positioning member in accordance with the flexible positioning sheet in theembodiment 1.

Fig. 3 is a front view of the flexible positioning member ofembodiment 2 using the flexible positioning plate.

Fig. 4 is a schematic view of the flexible splines of fig. 2.

FIG. 5 is a front view of the flexible positioning member in theembodiment 3 in which flexible positioning pieces are orthogonally arranged.

Wherein: 100 prior art electrode pads; 200 electrode plates; 300 electric field generating region; 1 a flexible substrate; 2 a flexible positioning member; 2-1 a first flexible locating tab; 2-2 flexible positioning plates; 2-3 second flexible locating plates; 3, connecting a lead externally; 4, sleeving a sleeve; 5 a flexible circuit board; 6, a containing groove; 7, edge gap; 8, positioning holes.

Detailed Description

For purposes of clarity and a complete description of the present invention, and the like, in conjunction with the detailed description, it is to be understood that the terms "central," "vertical," "lateral," "up," "down," "front," "back," "left," "right," "vertical," "horizontal," "top," "bottom," "inner," "outer," and the like are used in the orientation or positional relationship indicated in the drawings for convenience in describing and simplifying the present invention, but do not indicate or imply that the referenced device or element must have a particular orientation, be constructed and operated in a particular orientation, and thus should not be considered as limiting the present invention.

The specific implementation mode is as follows:

prior art is as shown in fig. 1, its priorart electrode slice 100 diameter is 19mm, and thickness is 1mm, and 9 priorart electrode slices 100 are arranged in "king" word and set up in the electricfield generating area 300 of width 90mm, height 110mm, refer to the computational formula of electric capacity:

；

wherein: epsilon_r-the relative dielectric constant;

s is the positive area of the capacitor plate;

k is the constant of electrostatic force;

d is the thickness of the electrode sheet;

it can be easily found in the calculation formula that the larger the electrode sheet area (S) and the smaller the electrode sheet thickness (d), the larger the capacitance value.

The energy density mentioned in the present application means: the ratio of the total effective area of the electrode sheets within the electricfield generation region 300 to the area of the electricfield generation region 300. The greater the ratio, the greater the energy density.

This application has adopted the lesslittle electrode slice 200 of diameter size for the manufacturing process of theelectrode slice 200 of this application compares in the manufacturing process of priorart electrode slice 100, and it is thin to add the work more easily in the aspect of the thickness, does not influence the mechanical properties ofelectrode slice 200 itself simultaneously, and then strengthenselectrode slice 200 capacitance value.

Example 1:

a novel electrode array for electric field therapy of tumors as shown in fig. 2 and 3, comprising: the flexible electrode plate comprises aflexible substrate 1, wherein an electric field generating region 300 (with the width of 90mm and the height of 110) is arranged on theflexible substrate 1, aflexible positioning part 2 is arranged in the electricfield generating region 300, 54 positioning holes 8 are formed in theflexible positioning part 2 in a staggered mode, aceramic electrode plate 200 is arranged in each positioning hole 8, and the 54electrode plates 200 are arranged in a staggered mode in the width-height mode of 6-9; the diameter of eachelectrode plate 200 is 10 mm. The 54 pieces of theelectrode plates 200 are connected by welding through theflexible circuit board 5. The area occupied by the 54electrode sheets 200 in this embodiment is 37.368 cm, the area occupied by the 9 priorart electrode sheets 100 is 22.5cm, the energy density of the 54electrode sheets 200 is that of the 9 prior art electrode sheets 100:

；

that is, in the present embodiment, theelectrode sheet 200 is reduced in size (diameter 10 mm) and is staggered in the electricfield generation region 300, so that the energy density of the electric field generation region 300 (width 90mm and height 110 mm) with the same area is greatly increased. Further, theelectrode sheet 200 of this application adopts 0.3 mm's thickness, refers to the computational formula of electric capacity, and the total capacitance value of 54electrode sheets 200 is compared the total capacitance value of 9 prior art electrode sheets 100 (1 mm thickness) and is promoted for the electric field intensity of the electrode array of this embodiment further promotes.

As shown in fig. 2 and 4, theflexible positioning component 2 in this embodiment includes 6 rows of first flexible positioning sheets 2-1 made of foam or silica gel, preferably, the first flexible positioning sheets 2-1 may be made of other flexible materials, a yielding groove 2-11 is provided at two sides of the first flexible positioning sheet 2-1 and between each two adjacent positioning holes, the first flexible positioning sheets 2-1 in the upper and lower rows are arranged in a staggered manner through the yielding grooves 2-11, the distance between theelectrode sheets 200 adjacent to the upper and lower rows of the two first flexible positioning sheets 2-1 is satisfied, theelectrode sheets 200 in the upper and lower rows can be bent and closed to a certain degree, and meanwhile, theelectrode sheets 200 in the lower 54 can be placed in the electricfield generation region 300 through the design that the first flexible positioning sheets 2-1 in the upper and lower rows are arranged in a staggered manner through the yielding grooves 2-11, so as to improve the space utilization rate, thereby increasing the energy density under the electricfield generation region 300 of the same area.

As shown in fig. 4, areceiving groove 6 is disposed in the first flexible positioning sheet 2-1 corresponding to theflexible circuit board 5, and is used for placing and fixing theflexible circuit board 5.

In this embodiment, the upper surface of eachelectrode plate 200 is higher than the upper surface of theflexible positioning member 2, so that theelectrode plates 200 can be better contacted with the skin of a patient, and the treatment effect can be improved.

Theflexible circuit board 5 is connected with a power supply device through anexternal lead 3, wherein the power supply device can output alternating current signals with adjustable voltage and frequency, the joint of theexternal lead 3 and theflexible circuit board 5 is provided with asleeve 4 made of rubber materials, and the sleeve is used for protecting the connection point of theexternal lead 3 and theflexible circuit board 5 and protecting a patient from being damaged by welding spots. Theflexible substrate 1 is made of medical adhesive tape, and a plurality ofedge notches 7 are uniformly formed in the edge of the flexible substrate and used for enabling the novel motor array patch to be attached to the skin of a patient more closely.

In the present embodiment, 54electrode sheets 200 are provided in the electricfield generating region 300 of 90mm × 110mm in order to treat the head of the patient, and it is preferable to increase the area of the electricfield generating region 300 and increase the number of theelectrode sheets 200 in an equal proportion, so that a large number of electrode array patches can be applied to other parts of the chest or lung of the patient to treat the head.

Example 2:

as shown in fig. 3, theflexible positioning component 2 in this embodiment is a whole piece of rectangular flexible positioning plate 2-2 made of foam or silicone, the preferred flexible positioning plate 2-2 is made of other flexible materials, 54 positioning holes 8 are formed in the flexible positioning plate, and the size and shape of the positioning holes 8 are matched with the size and shape of the electrode plate 200 (theelectrode plate 200 in this embodiment has a diameter of 10mm and a thickness of 0.3 mm). The flexible positioning plate 2-2 of the embodiment is designed to enable theelectrode plates 200 to be fixed more stably and firmly, but the degree of bending and closing of theelectrode plates 200 which are oppositely arranged in the upper row and the lower row and are adjacent to each other is reduced, so that the electrode plates are suitable for the parts of the patient with flat body.

Example 3;

as shown in fig. 5, theflexible positioning component 2 in the present embodiment includes 12 rows of second flexible positioning sheets 2-3 made of foam or silicone, preferably, the second flexible positioning sheets 2-3 are made of other flexible materials, each of the second flexible positioning sheets 2-3 is in a rectangular strip shape, 11 positioning holes 8 are uniformly arranged on the second flexible positioning sheet 2-3 at intervals, the diameter of theelectrode sheet 200 in the present embodiment is 6mm, the thickness of the electrode sheet is 0.3mm, 132electrode sheets 200 are arranged in the electric field generating region 300 (90 mm wide and 110mm high) of the present embodiment, the total effective area of theelectrode sheets 200 is 37.303cm, and the energy density ratio of theelectrode sheets 200 to that of theelectrode sheet 200 in the prior art is:

that is, the electrode array in this embodiment has higher energy density in the electricfield generation region 300 with the same area compared to the electrode array in the prior art, and further, the thickness of theelectrode sheet 200 in this embodiment is 0.3mm, which is improved compared to the total capacitance of 9 electrode sheets 100 (1 mm in thickness) in the prior art, so that the electric field strength of the electrode array in this embodiment is further improved.

Finally, it should be noted that: although the present invention has been described in detail with reference to the foregoing embodiments, it should be understood by those skilled in the art that: the technical solutions described in the foregoing embodiments may still be modified, or some technical features may be equivalently replaced; and such modifications or substitutions do not depart from the spirit and scope of the corresponding technical solutions of the embodiments of the present invention.

Claims (10)

1. A novel electrode array for electric field therapy of tumors, comprising: the flexible substrate comprises a flexible substrate (1), wherein an electric field generating area (300) is arranged on the flexible substrate (1), a flexible positioning component (2) is arranged in the electric field generating area (300), a plurality of ceramic electrode plates (200) are arranged on the flexible positioning component (2) in an array mode, and the electrode plates (200) are connected through a flexible circuit board (5); a plurality of positioning holes (8) are formed in the flexible positioning component (2), and the electrode plate (200) is arranged in the positioning holes (8);

the diameter of the electrode plate (200) is 3-15 mm.

2. The novel electrode array for electric field therapy of tumors as claimed in claim 1, wherein: the diameter of the electrode plate (200) is 5-10 mm.

3. The novel electrode array for electric field therapy of tumors as claimed in claim 1, wherein: the electrode plates (200) are arranged in a staggered mode.

4. The novel electrode array for electric field therapy of tumors as claimed in claim 1 or 2 or 3, characterized in that: the flexible positioning part (2) is a whole rectangular flexible positioning sheet or a plurality of flexible positioning sheets arranged in a row.

5. The novel electrode array for electric field therapy of tumors as claimed in claim 3, wherein: the flexible positioning component (2) comprises a plurality of flexible positioning sheets arranged, two adjacent rows of the flexible positioning sheets are arranged on the flexible positioning sheets, the positioning holes (8) are arranged in a staggered mode, and two sides of each flexible positioning sheet are provided with a yielding groove (2-11) between every two adjacent positioning holes (8).

6. The novel electrode array for electric field therapy of tumors as claimed in claim 3, wherein: and a containing groove (6) is arranged in the flexible positioning sheet corresponding to the flexible circuit board (5) and used for placing and fixing the flexible circuit board (5).

7. The novel electrode array for electric field therapy of tumors as claimed in claim 1, wherein: the thickness of the electrode slice (200) is 0.2-1 mm.

8. The novel electrode array for electric field therapy of tumors as claimed in claim 1, wherein: the upper surface of the electrode plate (200) is higher than the upper surface of the flexible positioning component (2).

9. The novel electrode array for electric field therapy of tumors as claimed in claim 1, wherein: the flexible circuit board (5) is connected with a power supply device through an external lead (3), and a sleeve (4) made of rubber is arranged at the joint of the external lead (3) and the flexible circuit board (5).

10. The novel electrode array for electric field therapy of tumors as claimed in claim 1, wherein: 54 electrode plates (200) are arranged in the electric field generating region (300) in a staggered manner, and the 54 electrode plates (200) are arranged in a staggered manner according to the width multiplied by the height of 6 multiplied by 9;

the diameter of the electrode plate (200) is 10mm, and the thickness is 0.3 mm.

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