this application enjoys the benefit of priority from U.S. patent application nos. 16/857 and 578, filed 24/2020 and japanese patent application No. 2021-042000, filed 16/3/2021, the entire contents of which are incorporated herein by reference.
Detailed Description
Reference throughout this specification to "one embodiment" or "an embodiment" means that a particular feature, structure, material, or characteristic described in connection with the embodiment is included in at least one embodiment of the present application and not present in all embodiments.
Therefore, the expressions "in one embodiment" or "in one embodiment" described in various places throughout the specification do not necessarily refer to the same embodiment of the present application. Furthermore, the particular features, structures, materials, or characteristics may be combined in any suitable manner in one or more embodiments.
First, a typical digital RF coil will be described with reference to fig. 1.
Fig. 1 shows a typicaldigital RF coil 101 having anADC 102 per channel, andchannel aggregators 103 arranged close to each other in a shielded box (shielded box). Thedigital RF coil 101 includes 8 channels 104-105. EachADC 102 has ananalog front end 106 and is connected to anRF coil antenna 107 associated with the corresponding channel.
As for such a configuration, there are proposed a plurality of schemes for bringing the ADC close to the analog front end, but those are not practical. This is because these proposals are carried out at increased cost, or because of digital data transmission and EMI radiated and conducted from the spectrum associated therewith, artifacts are generated in the image.
In current digital RF coil architectures, two different transmission lines, an electrical (e.g., coaxial, 3-axis) transmission line or an optical fiber transmission line, are used for transmitting digital acquisition data.
However, both of these kinds of transmission lines have problems.
Electrical transmission lines present two problems. Since data transmission between the ADC and the channel aggregator generates an artifact in an image due to EMI, the ADC needs to be disposed in the vicinity of the channel aggregator. High filtering, shielding, and electrical isolation of the PC substrate layout are required to suppress EMI noise, but these tend to cause high common mode (common mode) currents from the MR transmit field. Therefore, a cable trap (cable trap) is used to cope with a high common mode current. However, the weight and thickness thereof reduce the convenience of use for the operator, and in addition, the cost thereof is also high.
One disadvantage with optical fiber transmission lines is the high cost associated therewith. Laser transmitters and receivers are, for example, higher cost semiconductors (e.g., GaAs) than standard CMOS (Complementary Metal-Oxide Semiconductor) devices. Furthermore, the connector of the optical fiber consumes high power, and the RF coil is heated to raise the surface temperature to the limit of safe operation.
The present disclosure includes devices and methods for transmitting digital acquisition data within an RF coil of an MRI device using a non-conductive waveguide. Connectionless standard CMOS Millimeter Wave (mmWave) receivers and transmitters are used for the link between the ADC and the channel aggregator for each channel in the RF coil. Further, in order to transmit data between the transmitter and the receiver of the millimeter wave, a non-conductive waveguide (for example, a waveguide of polytetrafluoroethylene) is used.
The radio frequency coil, the magnetic resonance imaging apparatus, and the data transmission method according to the present invention will be described in detail below with reference to fig. 2 to 7.
Fig. 2 is an exemplary embodiment of an 8-channel digital MR-RF coil 201 representing the present application. Here, an 8-channel digital MR-RF coil is an example of a high-frequency coil. The 8-channel digital MR-RF coil 201 of the application comprises 8 channels 204-205, and the 8 channels 204-205 receive RF signals transmitted by a single MR examination. In each channel, an amplification anddata digitization unit 210, which includes ananalog front end 206 and anADC 202, receives signals from theRF coil antenna 207 and transmits the received signals to thechannel aggregator 203 via corresponding non-conductivemillimeter wave waveguides 211. Here, the amplifying and data digitizing means is an example of the data receiving section. Thechannel aggregator 203 transmits signals to and from the MR system via optical fibers or non-conductivemillimeter wave waveguides 216.
Each amplification anddata digitization unit 210 includes anADC 202 and an analogfront end 206.
Each of the nonconductivemillimeter wave waveguides 211 includes amillimeter wave transmitter 208 at one end portion that receives a signal from the amplification anddata digitization unit 210, and amillimeter wave receiver 209 at the other end portion that is connected to thechannel aggregator 203. Themillimeter wave transmitter 208 and themillimeter wave receiver 209 are connected via aplastic waveguide 212. Here, a plastic waveguide is an example of a waveguide. TheADCs 202 of the various channels are connected via acontrol path 213, which controlpath 213 is likewise connected to thechannel aggregator 203 via a non-conductivemillimeter wave waveguide 211.
For encoding the data stream, an 8B/10B coding scheme (encoding scheme) may also be used. The 8B/10B coding scheme ensures DC balance of the integrity of the serial data stream and, in addition, the downstream receiver provides sufficient bit (bit) conversion to be able to maintain clock recovery.
Fig. 3 shows details of a non-conductivemillimeter wave waveguide 311 for use in the 8-channel digital MR-RF coil of the present application.
Specifically, amillimeter wave transmitter 308 and amillimeter wave receiver 309 are disposed at each end of theplastic waveguide 312. In one embodiment, theplastic waveguide 312 comprises Polytetrafluoroethylene (PTFE) or other low cost non-conductive plastic or polymer.
In addition, here, an example of a case where a plastic waveguide is used as a waveguide connecting the millimeter wave transmitter and the millimeter wave receiver is described, but the embodiment is not limited thereto. For example, a waveguide formed of glass (quartz or the like), acrylic (acrylic), polycarbonate (polycarbonate), polymer (polymethyl methacrylate) resin, or the like may be used.
Themillimeter wave transmitter 308 includes a transmitter Integrated Circuit (IC) having an Integrated millimeterwave transmission antenna 313, and the Integrated millimeterwave transmission antenna 313 is coupled to theplastic waveguide 312 via aplastic waveguide coupler 315. Further, themillimeter wave receiver 309 is provided with a receiver IC having an integrated millimeterwave receiving antenna 314 at the other end of the data transmission link, the integrated millimeterwave receiving antenna 314 being coupled with theplastic waveguide 312 via aplastic waveguide coupler 316. Here, a plastic waveguide coupler is an example of the waveguide coupler. In one embodiment, the transmitter IC and the receiver IC comprise standard CMOS devices or other low cost semiconductor devices.
Fig. 4 shows details ofmillimeter wave transmitter 408 andmillimeter wave receiver 409 of the present application and their connection to the plastic waveguide. In one embodiment,millimeter wave transmitter 408 is provided with aplastic waveguide coupler 415 mounted on top of integrated millimeter wave transmitantenna 413. When the wave is emitted from the integrated millimeterwave transmitting antenna 413, for example, Er 1.0 is set as a propagation mode, and the outer field of the coupler (Er 1.0) is attenuated by an exponential function. Theplastic waveguide 412 is inserted into the respective opening portions of theplastic waveguide couplers 415 and 416. Also, inmillimeter wave receiver 409,plastic waveguide coupler 416 is mounted on the upper portion of integrated millimeterwave receiving antenna 414.
Fig. 5 is an exemplary layout of an 8-channel digital MR-RF coil 501 representing the present application. In one embodiment, an array of loop antennas, an amplification and acquisition data digitization unit, a non-conductive millimeter wave waveguide, and a channel aggregator are disposed on thesubstrate 517.
Specifically, 8loop antennas 507 are symmetrically arranged on one side of each of the corresponding 8 nonconductivemillimeter wave waveguides 511. The amplification anddata digitization unit 510 is connected to thecorresponding loop antenna 507 via anelectrical connection 518, and transmits the received data to thechannel aggregator 503 disposed on the side of thesubstrate 517 via the corresponding non-conductivemillimeter wave waveguide 511 for each channel. The digital data received by thechannel aggregator 503 is transceived with the MR system via the optical fiber or the non-conductivemillimeter wave waveguide 516.
Fig. 6 shows a configuration of achannel aggregator 601 of the present application. Thechannel aggregator 601 receives input signals 602-603 from different channels. Here, each input signal is a serial data stream of a bit rate (bit rate) X. Abuffer 604 within thechannel aggregator 601 receives the input stream and sends the data to a dual port RAM (Random Access Memory) 605. Thechannel aggregator 601 outputs the data as a serial stream at a bit rate of X (n + 1).
Fig. 7 is a diagram showing a configuration example of an MRI apparatus according to the present application.
For example, as shown in fig. 1, theMRI apparatus 100 includes a static magnetic field magnet 1, a gradient magnetic field coil 2, a gradient magnetic field power supply 3, a whole-body RF (Radio Frequency) coil 4, a local RF coil 5, atransmission circuit 6, a reception circuit 7, an RF shield 8, agantry 9, acouch 10, aninput interface 11, adisplay 12, a storage circuit 13, and processing circuits 14 to 16.
The static magnetic field magnet 1 generates a static magnetic field in an imaging space in which the subject S is disposed. Specifically, the static magnetic field magnet 1 is formed in a hollow substantially cylindrical shape (a shape including a cross section orthogonal to the central axis is an elliptical shape), and generates a static magnetic field in an imaging space formed on the inner peripheral side thereof. The static field magnet 1 is, for example, a superconducting magnet or a permanent magnet. The superconducting magnet referred to herein is constituted by a vessel filled with a coolant such as liquid helium (helium) and a superconducting coil immersed in the vessel.
The gradient coil 2 is disposed inside the static field magnet 1, and generates a gradient magnetic field in an imaging space in which the subject S is disposed. Specifically, the gradient coil 2 is formed in a hollow substantially cylindrical shape (a shape including a cross section orthogonal to the central axis is an elliptical shape), and includes an X coil, a Y coil, and a Z coil corresponding to an X axis, a Y axis, and a Z axis orthogonal to each other. The X coil, the Y coil, and the Z coil generate a gradient magnetic field in the imaging space, which linearly changes in each axial direction, based on a current supplied from the gradient magnetic field power supply 3. Here, the Z axis is set to a magnetic flux along the static magnetic field generated by the static field magnet 1. The X axis is set along a horizontal direction orthogonal to the Z axis, and the Y axis is set along a vertical direction orthogonal to the Z axis. Thus, the X-axis, Y-axis, and Z-axis constitute an apparatus coordinate system unique to theMRI apparatus 100.
The gradient magnetic field power supply 3 supplies a current to the gradient magnetic field coil 2, thereby generating a gradient magnetic field in the imaging space. Specifically, the gradient magnetic field power supply 3 supplies currents to the X coil, the Y coil, and the Z coil of the gradient magnetic field coil 2 individually, thereby generating a gradient magnetic field in the imaging space that linearly changes in the readout (readout) direction, the phase encoding direction, and the slice (slice) direction, which are orthogonal to each other. Hereinafter, the gradient magnetic field along the readout direction is referred to as a readout gradient magnetic field, the gradient magnetic field along the phase encoding direction is referred to as a phase encoding gradient magnetic field, and the gradient magnetic field along the slice direction is referred to as a slice gradient magnetic field.
Here, the readout gradient magnetic field, the phase encode gradient magnetic field, and the slice gradient magnetic field are superimposed on the static magnetic field generated by the static magnetic field magnet 1, respectively, to provide spatial position information on the magnetic resonance signal generated from the subject S. Specifically, the readout gradient magnetic field changes the frequency of the magnetic resonance signal in accordance with the position in the readout direction, thereby giving the magnetic resonance signal position information along the readout direction. The phase encoding gradient magnetic field changes the phase of the magnetic resonance signal in the phase encoding direction, thereby giving the magnetic resonance signal positional information in the phase encoding direction. Furthermore, the slice gradient magnetic field imparts positional information along the slice direction to the magnetic resonance signals. For example, when the imaging region is a slice region (2D imaging), the slice gradient magnetic field is used to determine the direction, thickness, and number of slices, and when the imaging region is a volume region (3D imaging), the slice gradient magnetic field is used to change the phase of the magnetic resonance signal according to the position in the slice direction. Thus, an axis along the readout direction, an axis along the phase encode direction, and an axis along the slice direction constitute a logical coordinate system for defining a slice region or volume region to be imaged.
The whole-body RF coil 4 is disposed on the inner peripheral side of the gradient magnetic field coil 2, applies an RF magnetic field (excitation pulse or the like) to the subject S disposed in the imaging space, and receives a magnetic resonance signal (echo signal or the like) generated from the subject S by the RF magnetic field. Specifically, the whole-body RF coil 4 is formed in a hollow substantially cylindrical shape (a shape including a cross section orthogonal to the central axis is an elliptical shape), and applies an RF magnetic field to the subject S disposed in the imaging space located on the inner peripheral side thereof based on the RF pulse supplied from thetransmission circuit 6. The whole-body RF coil 4 receives a magnetic resonance signal generated from the subject S due to the influence of the RF magnetic field, and outputs the received magnetic resonance signal to the receiving circuit 7.
The local RF coil 5 receives a magnetic resonance signal generated from the subject S. Specifically, the local RF coil 5 is prepared for each part of the subject S, and when imaging the subject S, the local RF coil 5 is disposed near the surface of the part to be imaged. The local RF coil 5 receives a magnetic resonance signal generated from the subject S under the influence of the RF magnetic field applied by the whole-body RF coil 4, and outputs the received magnetic resonance signal to the receiving circuit 7. The local RF coil 5 may also have a function of applying an RF magnetic field to the subject S. In this case, the local RF coil 5 is connected to thetransmission circuit 6, and applies an RF magnetic field to the subject S based on an RF pulse supplied from thetransmission circuit 6. For example, the local RF coil 5 is a surface coil (surface coil) or a phased array coil (phased array coil) configured by combining a plurality of surface coils into a coil element. Here, the local RF coil 5 has the configuration of the 8-channel digital RF coil described above.
Thetransmission circuit 6 outputs an RF pulse corresponding to a Larmor (Larmor) frequency specific to the target nucleus placed in the static magnetic field to the whole body RF coil 4.
The receiving circuit 7 generates magnetic resonance data based on the magnetic resonance signal output from the whole-body RF coil 4 or the local RF coil 5, and outputs the generated magnetic resonance data to the processing circuit 15. Here, the receiving circuit 7 corresponds to the MR system described above.
The RF shield 8 is disposed between the gradient coil 2 and the whole-body RF coil 4, and shields the gradient coil 2 from the RF magnetic field generated by the whole-body RF coil 4. Specifically, the RF shield 8 is formed in a hollow substantially cylindrical shape (a shape including a cross section perpendicular to the central axis of the cylinder is an elliptical shape), and is disposed in a space on the inner peripheral side of the gradient coil 2 so as to cover the outer peripheral surface of the whole-body RF coil 4.
Thegantry 9 has a hollow cavity (bore)9a formed in a substantially cylindrical shape (a shape including an elliptical cross section perpendicular to the central axis), and houses the static field magnet 1, the gradient coil 2, the whole body RF coil 4, and the RF shield 8. Specifically, thegantry 9 houses the whole-body RF coil 4 on the outer periphery of thecavity 9a, the RF shield 8 on the outer periphery of the whole-body RF coil 4, the gradient coil 2 on the outer periphery of the RF shield 8, and the static field magnet 1 on the outer periphery of the gradient coil 2. Here, the space in thecavity 9a of thegantry 9 is an imaging space in which the subject S is disposed during imaging.
Thebed 10 includes atop plate 10a on which the subject S is placed, and moves thetop plate 10a on which the subject S is placed into the imaging space when imaging the subject S. For example, thebed 10 is provided such that the longitudinal direction of thetop plate 10a is parallel to the central axis of the static field magnet 1.
Here, an example in which theMRI apparatus 100 has a so-called tunnel (tunnel) type structure in which the static field magnet 1, the gradient magnetic field coil 2, and the whole-body RF coil 4 are each formed in a substantially cylindrical shape has been described, but the embodiment is not limited to this. For example, theMRI apparatus 100 may have a so-called open (open) structure in which a pair of static field magnets, a pair of gradient field coils, and a pair of RF coils are arranged so as to face each other with an imaging space in which the subject S is arranged interposed therebetween. In such an open structure, a space sandwiched by the pair of static field magnets, the pair of gradient field coils, and the pair of RF coils corresponds to a cavity in the tunnel structure.
Theinput interface 11 receives various instructions and input operations of various information from an operator. Specifically, theinput interface 11 is connected to the processing circuit 17, converts an input operation received from an operator into an electric signal, and outputs the electric signal to the processing circuit 17. Theinput interface 11 is realized by, for example, a trackball for setting imaging conditions and a Region Of Interest (ROI), a switch button, a mouse, a keyboard, a touch panel for performing input operations by touching an operation surface, a touch panel in which a display screen and the touch panel are integrated, a non-contact input circuit using an optical sensor, a voice input circuit, and the like. In the present specification, theinput interface 11 is not limited to a physical operation member including a mouse, a keyboard, and the like. For example, a processing circuit that receives an electric signal corresponding to an input operation from an external input device provided independently of the apparatus and outputs the electric signal to the control circuit is also included in theinput interface 11.
Thedisplay 12 displays various information. Specifically, thedisplay 12 is connected to the processing circuit 17, and converts data of various kinds of information sent from the processing circuit 17 into electric signals for display and outputs the electric signals. Thedisplay 12 is realized by, for example, a liquid crystal monitor, a CRT monitor, a touch panel, or the like.
The memory circuit 13 stores various data. Specifically, the memory circuit 13 is connected to the processing circuits 14 to 17, and stores various data input/output through each processing circuit. The Memory circuit 13 is implemented by a semiconductor Memory element such as a RAM (Random Access Memory) or a flash Memory, a hard disk, an optical disk, or the like.
The processing circuit 14 has a couch control function 14 a. The bed control function 14a outputs a control electric signal to thebed 10, thereby controlling the operation of thebed 10. For example, the couch control function 14a operates the movement mechanism of thetop plate 10a included in thecouch 10 so as to receive an instruction to move thetop plate 10a in the longitudinal direction, the vertical direction, or the horizontal direction from the operator via theinput interface 11, and move thetop plate 10a in accordance with the received instruction.
The processing circuit 15 has a data acquisition function 15 a. The data acquisition function 15a acquires k-space data by executing various pulse sequences. Specifically, the data acquisition function 15a executes various pulse sequences by driving the gradient magnetic field power supply 3, thetransmission circuit 6, and the reception circuit 7 in accordance with the sequence execution data output from the processing circuit 17. Here, the sequence execution data is data indicating a pulse sequence, and is information specifying the timing at which the gradient magnetic field power supply 3 supplies a current to the gradient magnetic field coil 2 and the intensity of the supplied current, the timing at which thetransmission circuit 6 supplies an RF pulse to the whole-body RF coil 4 and the intensity of the supplied radio-frequency pulse, the timing (timing) at which the reception circuit 7 samples (samples) a magnetic resonance signal, and the like. Also, the data acquisition function 15a receives the magnetic resonance data output from the reception circuit 7 as a result of execution of the pulse sequence, and stores it in the storage circuit 13. At this time, the magnetic resonance data stored in the storage circuit 13 is given with positional information in each of the readout direction, the phase encoding direction, and the slice direction by the above-described gradient magnetic fields, and is stored as k-space data representing a two-dimensional or three-dimensional k-space.
The processing circuit 16 has animage generating function 16 a. Theimage generation function 16a generates an image from the k-space data acquired by the processing circuit 15. Specifically, theimage generating function 16a reads out k-space data acquired by the processing circuit 15 from the storage circuit 13, and performs reconstruction processing such as Fourier (Fourier) conversion on the read-out k-space data to generate a two-dimensional or three-dimensional image. Then, theimage generating function 16a stores the generated image in the storage circuit 13.
The processing circuit 17 has an imagepickup control function 17 a. Theimaging control function 17a controls each component of theMRI apparatus 100 to perform overall control of theMRI apparatus 100. Specifically, theimaging control function 17a displays a GUI (Graphical User Interface) for receiving various instructions and input operations of various information from the operator on thedisplay 12, and controls each component of theMRI apparatus 100 in accordance with the input operations received via theinput Interface 11. For example, theimaging control function 17a generates sequence execution data based on the imaging conditions input by the operator, and outputs the generated sequence execution data to the processing circuit 15, thereby acquiring k-space data. Further, for example, theimaging control function 17a controls the processing circuit 16 to reconstruct an image from the k-space data acquired by the processing circuit 15. Further, for example, theimaging control function 17a reads out an image from the storage circuit 13 in response to a request from the operator, and causes thedisplay 12 to display the read-out image.
Here, the processing circuits 14 to 17 are realized by a processor, for example. In this case, the processing functions of the processing circuits are stored in the storage circuit 13 in the form of a program that can be executed by a computer, for example. Each processing circuit reads out each program from the storage circuit 13 and executes the program, thereby realizing a processing function corresponding to each program. In other words, each processing circuit in which the state of each program is read has each function shown in each processing circuit of fig. 1.
In addition, although the case where each processing circuit is realized by a single processor has been described here, the present invention is not limited to this, and each processing circuit may be configured by combining a plurality of independent processors, and each processing function may be realized by each processor executing a program. Further, the processing functions of the processing circuits may be distributed or integrated in a single or a plurality of processing circuits as appropriate. In the example shown in fig. 1, the case where the single memory circuit 13 stores the programs corresponding to the respective processing functions has been described, but a configuration may be adopted in which a plurality of memory circuits are arranged in a distributed manner, and the processing circuit reads the corresponding programs from the single memory circuit.
In the above description, an example has been described in which the "processor" reads out and executes a program corresponding to each processing function from the memory circuit, but the embodiment is not limited to this. The expression "processor" means, for example, a CPU (Central Processing Unit), a GPU (Graphics Processing Unit), an Application Specific Integrated Circuit (ASIC), a Programmable Logic Device (e.g., Simple Programmable Logic Device (SPLD)), a Complex Programmable Logic Device (CPLD), and a Field Programmable Gate Array (FPGA)). In the case where the processor is, for example, a CPU, the processor reads out and executes a program stored in the storage circuit, thereby realizing each processing function. On the other hand, when the processor is an ASIC, the processing function is directly incorporated as a logic circuit in the circuit of the processor, instead of storing a program in a memory circuit. Note that each processor of the present embodiment is not limited to the case where each processor is configured as a single circuit, and a plurality of independent circuits may be combined to configure one processor and realize the processing function thereof. Furthermore, a plurality of components in fig. 1 may be integrated into one processor to realize the processing function.
Here, the program executed by the processor is provided by being incorporated in advance into a ROM (Read Only Memory), a Memory circuit, or the like. The program may be provided as a file in a form that can be installed in or executed by these apparatuses, and may be recorded on a computer-readable storage medium such as a CD (Compact Disk) -ROM, FD (Flexible Disk), CD-R (Recordable Disk), DVD (Digital Versatile Disk), or the like. The program may be stored in a computer connected to a network such as the internet, downloaded via the network, and provided or distributed. For example, the program is constituted by modules including the above-described functional units. As actual hardware, the CPU reads and executes a program from a storage medium such as a ROM to load each module on the main storage device, thereby generating each module on the main storage device.
According to the digital MR-RF coil of the present application, the ADC and the related digital data transmission circuit can be disposed in the vicinity of the analog feed point (analog feed point) without generating EMI. Further, multiple cable notches, filtering, and shadowing can be removed for each channel. This can reduce the weight of the coil and improve the efficiency of the work flow.
Furthermore, according to the digital MR-RF coil of the present application, it is possible to achieve electrical isolation between the digitizing circuit and the aggregation circuit within the coil, and to achieve lower cost data transmission in comparison with a digital RF coil having an optical fiber transmission line.
In view of the above, various modifications and variations can be made to the embodiments presented in this specification. Therefore, it is to be understood that the present disclosure may be practiced by methods other than those specifically recited in the claims.
According to at least one embodiment described above, an image artifact caused by EMI can be prevented.
Although several embodiments have been described, these embodiments are presented as examples and are not intended to limit the scope of the invention. These embodiments can be implemented in other various manners, and various omissions, substitutions, changes, and combinations of the embodiments can be made without departing from the scope of the invention. These embodiments and modifications thereof are included in the scope and gist of the invention, and are also included in the invention described in the claims and the equivalent scope thereof.