CN113521542A - Magnetic ring array device for treatment - Google Patents

Abstract

The invention relates to the field of medical equipment, and discloses a magnetic ring array device for treatment, which comprises at least two closed magnetic rings or magnetic chains, wherein each magnetic ring or magnetic chain is arranged into a fan shape, a circular shape or a spherical arc shape and then is fixed on a fixed support to form a magnetic ring array; in the magnetic ring array, preset alternating electric fields generated in each magnetic ring or magnetic chain are superposed and converged at one focus. When the rapid dividing device is used, the carrier of the rapidly dividing tumor cells is directly placed on the convergence focus of the preset alternating electric field generated in each magnetic ring or magnetic chain in the magnetic ring array, the superposed alternating electric field can be generated in the rapidly dividing tumor cells, similar energy concentration is realized, the diseased part can be effectively treated, the alternating electric fields in different directions can be generated, and the diseased part can be conveniently treated from different angles.

Description

Magnetic ring array device for treatment

Technical Field

The invention relates to the field of medical instruments, in particular to a magnetic ring array device for treatment.

Background

It is well known that tumors, particularly malignant tumors or cancers, have uncontrolled, unlimited proliferation of cell division, rapid growth, low cell differentiation, and infiltration and diffusion (migration) compared to normal tissues.

As mentioned above, rapid growth of tumors (particularly malignant tumors) is often the result of relatively frequent cell division or proliferation as compared to normal tissue cells. The frequent cell division of cancer cells relative to normal cells is the basis for the effectiveness of existing cancer treatments, such as radiation therapy and the use of a wide variety of chemotherapeutic agents. Such treatments are based on the fact that cells undergoing division are more sensitive to radiation and chemotherapeutic agents than non-dividing cells. Because tumor cells divide more frequently than normal cells, it is possible to some extent to selectively damage or destroy tumor cells by radiation therapy and/or chemotherapy. The actual sensitivity of cells to radiation, therapeutic agents, etc. also depends on the specific characteristics of the different types of normal or malignant cell types. Thus, unfortunately, the sensitivity of tumor cells is not significantly higher than many types of normal tissue. This makes it less distinguishable between tumor cells and normal cells, and thus existing cancer-typical treatment regimens can also cause significant damage to normal cells, thereby limiting the therapeutic efficacy of such treatment regimens. Furthermore, the inevitable damage to other tissues makes the treatment very damaging to the patient and the patient often cannot recover from an apparently successful treatment. Also, certain types of tumors are not sensitive at all to existing treatments.

Other methods for destroying cells exist that do not rely on radiation therapy or chemotherapy alone. For example, methods of destroying tumor cells using ultrasound or electricity may be used in place of conventional therapeutic methods. Electric fields and currents have been used for many years for medical purposes. Most commonly, an electric current is generated in the body of a human or animal by applying an electric field to the body of the human or animal by means of a pair of conducting electrodes between which a potential difference is maintained. These currents are either used to exert their special effect, i.e. to stimulate excitable tissues, or to generate heat by creating currents in the body, since the body can be equivalently resistive. Examples of the first type of application include: cardiac defibrillators, peripheral nerve and muscle stimulators, brain stimulators, and the like. Examples of the use of electric current for generating heat include: tumor resection, resection of malfunctioning heart or brain tissue, cauterization, relief of muscle rheumatalgia or other pain, and the like.

Other applications of electric fields for medical purposes include the use of high frequency oscillating fields emitted from sources emitting e.g. radio frequency electric waves or microwave sources directed to a region of interest of the body. In these examples, there is no electrical energy conduction between the source and the body; but rather energy is transferred to the body by radiation or induction. More particularly, the electrical energy generated by the source reaches the vicinity of the body via a conductor and is transmitted from this location to the human body through air or some other electrically insulating material.

In conventional electrical methods, electrical current is delivered to a target tissue region through electrodes placed in contact with the patient's body. The applied current will destroy substantially all cells in the vicinity of the target tissue. Thus, this type of electrical approach does not distinguish between different types of cells within the target tissue and results in destruction of both tumor and normal cells.

Application No. 200580048335.X, entitled apparatus for selectively destroying or inhibiting the growth of rapidly dividing tumor cells located within a target region of a patient, discloses that the apparatus comprises: at least two pairs of insulated electrodes (1620, 1630), wherein each electrode (1620, 1630) has a surface configured for placement against a patient's body; and an AC voltage source having at least two sets of outputs, wherein the at least two sets of outputs are phase shifted and are each electrically connected to one of the at least two pairs of insulated electrodes (1620, 1630); wherein the AC voltage source and the electrodes (1620, 1630) are configured such that when the electrodes (1620, 1630) are placed in close proximity to the patient's body, an AC electric field is applied into the patient's target region (1612) in a direction that is rotated relative to the target region (1612) due to a phase shift between at least two sets of outputs, the applied electric field having frequency and field strength characteristics such that the electric field (a) selectively destroys rapidly dividing tumor cells, and (b) leaves normal cells substantially unharmed. The device better distinguishes between dividing cells (including unicellular tissue) and non-dividing cells, and is capable of selectively destroying rapidly dividing tumor cells without substantially affecting normal cells or the body. However, when the device is used, the electrodes therein must be tightly adhered to the skin of the patient, which is not suitable for long-term use and has low use comfort. And the electrode has certain life, must regularly change, and use cost is extremely high.

Disclosure of Invention

The purpose of the invention is as follows: the invention provides a magnetic ring array device for treatment, which can selectively destroy tumor cells without influencing normal cells or organisms basically. The device has no electrode, is not required to be tightly attached to the skin for use, can be worn or used for a long time, and has higher comfort level.

The technical scheme is as follows: the invention provides a magnetic ring array device for treatment, which comprises at least two closed magnetic rings or magnetic chains, wherein each magnetic ring or magnetic chain is arranged into a fan shape, a circular shape or a spherical arc shape and then is fixed on a fixed support to form a magnetic ring array; in the magnetic ring array, preset alternating electric fields generated in each magnetic ring or magnetic chain are superposed and converged at a focus; the alternating signal generating circuit is any one of the following: a constant-amplitude sine wave generator circuit, a reducing sine wave generator circuit, an amplifying sine wave generator circuit, a sine wave generator circuit with amplitude increasing and then reducing, and a sine wave circuit with frequency continuously changing between the maximum value and the minimum value; the inductance in each sine wave generator circuit is the metal coil; and loading preset alternating current with the signal frequency of the current waveform of 30 kHz-300 kHz on each metal coil through the alternating signal generating circuit, wherein the preset alternating current can generate a preset alternating magnetic field in the corresponding magnetic ring or magnetic chain, and the preset alternating magnetic field can form a preset alternating electric field with the intensity of 0.1V/cm-10V/cm, which is used for destroying or inhibiting the rapidly dividing tumor cells in the carrier and has no effect on normal cells, in the direction perpendicular to the corresponding magnetic ring or magnetic chain.

Furthermore, the device also comprises a random/periodic signal generating circuit, an electric control switch is respectively connected between the VDD power supply and the input end of each alternating signal generating circuit, and the output signal of the random/periodic signal generating circuit is used for controlling each electric control switch. The random/periodic signal generating circuit may control the alternating signal generating circuit so as to divide the generated alternating signal into a plurality of series, and the time of occurrence of each series may be periodic, random or continuous.

Preferably, the constant-amplitude sine wave generator circuit is a clar wave oscillation circuit or a chaylor oscillation circuit, and the output current waveform of the preset alternating current is a continuous constant-amplitude sine wave, multiple groups of constant-amplitude sine waves with periodic time intervals, or multiple groups of constant-amplitude sine waves with random time intervals.

Preferably, the constant-amplitude sine wave generator circuit mainly comprises a sawtooth wave generator and a voltage-controlled oscillator, wherein sawtooth wave voltage generated by the sawtooth wave generator controls the voltage-controlled oscillator, and the output current waveform of the preset alternating current is a similar frequency modulation continuous FMCW wave.

Preferably, the constant-amplitude sine wave generator circuit mainly comprises a triangular wave generator and a voltage-controlled oscillator, and the voltage-controlled oscillator takes the metal coil after being connected in series as a load; the triangular wave voltage generated by the triangular wave generator controls the voltage-controlled oscillator, and the output current waveform of the preset alternating current is similar to a frequency modulation continuous FMCW wave, multiple groups of FMCW waves with periodic time intervals or multiple groups of FMCW waves with random time intervals.

Preferably, the constant-amplitude sine wave generator circuit mainly comprises a sine wave generator and a voltage-controlled oscillator, and the voltage-controlled oscillator takes the metal coils connected in series as a load; the sine wave voltage generated by the sine wave generator controls the voltage-controlled oscillator, and the current waveform of the output preset alternating current is similar to a frequency modulation continuous FMCW wave, multiple groups of FMCW waves with periodic time intervals or multiple groups of FMCW waves with random time intervals.

Preferably, the number of the amplitude-reducing sine wave generator circuits is equal to that of the magnetic rings or magnetic chains, and each voltage-controlled oscillator is connected with one metal coil as a load; the sine wave voltage generated by the sine wave generator controls each voltage-controlled oscillator, and the current waveform of the output preset alternating current is similar to a frequency modulation continuous FMCW wave, multiple groups of FMCW waves with periodic time intervals or multiple groups of FMCW waves with random time intervals.

Preferably, the amplitude-reduced sine wave generator circuit is an LC oscillator circuit, and the output current waveform of the preset alternating current is a continuous amplitude-reduced sine wave, multiple groups of amplitude-reduced sine waves with periodic time intervals, or multiple groups of amplitude-reduced sine waves with random time intervals.

Preferably, the amplification sine wave generator circuit mainly comprises a high-frequency sine wave generator, a sawtooth wave generator and an analog multiplier circuit, and the analog multiplier circuit takes the metal coil after being connected in series as a load; and multiplying the high-frequency sine wave generated by the high-frequency sine wave circuit by the sawtooth wave generated by the sawtooth wave generator, wherein the output current waveform of the preset alternating current is a continuous amplification sine wave, multiple groups of amplification sine waves with periodic time intervals or multiple groups of amplification sine waves with random time intervals.

Preferably, the first increase and then decrease sine wave generator circuit mainly comprises a high-frequency sine wave generator, a low-frequency sine wave generator and an analog multiplier circuit, wherein the analog multiplier circuit takes the metal coil after being connected in series as a load; and multiplying the high-frequency sine wave generated by the high-frequency sine wave generator by the low-frequency sine wave generated by the low-frequency sine wave generator, wherein the output current waveform of the preset alternating current is that the amplitude is increased and then reduced by a continuous sine wave, the amplitudes of a plurality of groups of periodic time intervals are increased and then reduced by a sine wave or the amplitudes of a plurality of groups of random time intervals are increased and then reduced by a sine wave.

Preferably, the first increase and then decrease sine wave generator circuit mainly comprises a high-frequency sine wave generator, a triangular wave generator and an analog multiplier circuit, wherein the analog multiplier circuit takes the metal coil after being connected in series as a load; and multiplying the high-frequency sine wave generated by the high-frequency sine wave generator by the triangular wave generated by the triangular wave generator, wherein the output current waveform of the preset alternating current is the sine wave with the amplitude increased and then reduced, the sine wave with the amplitude increased and then reduced at a plurality of groups of periodic time intervals, or the sine wave with the amplitude increased and then reduced at a plurality of groups of random time intervals.

The working principle is as follows: when the device is used, a carrier of cells which are rapidly dividing is placed on a convergence focus of a preset alternating electric field generated in each magnetic ring or magnetic chain in the magnetic ring array, alternating current with specific frequency and amplitude is generated after an alternating signal generating circuit is electrified, when the alternating current is output to each metal coil, a preset alternating magnetic field is generated in each magnetic ring or magnetic chain, the direction of the alternating magnetic field is consistent with the direction of the magnetic ring or magnetic chain, and a closed loop is formed as the same as the magnetic ring or magnetic chain. The alternating magnetic field forms an alternating electric field in its vertical direction, i.e. in a direction perpendicular to the magnetic ring or flux linkage plane. Since the magnetic rings or flux linkages are an array of magnetic rings arranged in a sector, circle or spherical arc, the predetermined alternating electric field generated within each magnetic ring or flux linkage can converge at a focal point where the carrier of the rapidly dividing cells (usually the patient) is located. Since cells are more susceptible to damage from alternating electric fields having specific frequency and electric field strength characteristics when they are rapidly dividing. Therefore, when the carrier of the rapidly dividing tumor cell is located at the focus of each alternating electric field, the rapidly dividing tumor cell located in the superimposed alternating electric field will generate a superimposed alternating voltage, the superimposed alternating voltage will induce a superimposed alternating electric field with the same frequency as the alternating current in the coil in the rapidly dividing tumor cell, the alternating electric field with the specific frequency and electric field strength characteristic lasts for a period of time, the rapidly dividing tumor cell can be selectively destroyed, and the normal cell will not be damaged because it is insensitive to the alternating electric field with the specific frequency and electric field strength characteristic. This selectively destroys rapidly dividing cells like tumor cells without damaging normal cells.

Has the advantages that: when the device is used, the carrier of the rapidly dividing tumor cells is directly placed on the convergence focus of the preset alternating electric field generated in each magnetic ring or magnetic chain in the magnetic ring array, compared with a treatment device with a single magnetic ring or magnetic chain, the device can generate a superposed alternating electric field in the rapidly dividing tumor cells, and the superposed alternating electric field has a focusing effect, the electric field intensity is larger, the energy is more concentrated, and the diseased part can be more effectively treated.

The device has no electrode, is not required to be used by being clung to the skin, can be worn or used for a long time, and has higher comfort level; can selectively destroy a rapidly dividing cell or body without substantially affecting normal cells or bodies.

Drawings

FIG. 1 is a schematic structural diagram of an arc-shaped magnetic ring array device for therapeutic use;

FIG. 2 is an enlarged schematic view of the structure within the dotted circle of FIG. 1;

FIG. 3 is a schematic structural diagram of a circular magnetic ring array device for therapeutic use;

FIG. 4 is an enlarged schematic view of the inside of the dotted circle in FIG. 3;

FIG. 5 is a schematic view of a spherical arc-shaped therapeutic magnetic ring array device;

FIG. 6 is a schematic structural diagram of a magnetic ring array device for therapeutic use, in which an alternating current signal generating circuit powered by VDD inputs an alternating current signal to an inductor;

fig. 7 is a schematic structural diagram of a magnetic ring array device for therapeutic use inembodiment 1, which includes a random/periodic signal generating circuit, wherein the inductance coils are connected in series, amplitude-reduced sine wave current signals with identical periodic time intervals or random time intervals flow through the inductance coils, and the alternating signal generating circuit loads preset alternating currents on the metal coils;

FIG. 8 is a schematic diagram of the switching power supply circuit providing a supply voltage VDD to subsequent circuits that convert the system power supply to a suitable DC power supply for the subsequent circuits;

FIG. 9 is a circuit diagram for generating sets of randomly time spaced reduced sine waves, showing only three sets of magnetic loop circuits (including three inductors, three magnetic loops or flux linkages), and may be virtually any set of magnetic loop circuits greater than or equal to 2;

FIG. 10 is a graph of a plurality of sets of randomly time spaced dampened sinusoidal waveforms generated by the circuit shown in FIG. 9;

FIG. 11 is a circuit diagram for generating sets of stepped-down sinusoidal waves at periodic intervals, wherein only three sets of magnetic loop circuits (including three inductors, three magnetic loops, or flux linkages) are shown, and in fact any set of magnetic loop circuits greater than or equal to 2 may be used;

FIG. 12 is a graph of a plurality of sets of periodic time interval dampened sinusoidal wave waveforms generated by the circuit shown in FIG. 11;

FIG. 13 is a Krah wave oscillator circuit, one of the constant amplitude sine wave generator circuits for generating a continuous constant amplitude sine wave, in which the inductors are divided into three sets of inductors connected in series, and can be loaded on three magnetic rings or magnetic chains, and actually can be any set of inductor and magnetic ring circuit greater than or equal to 2;

FIG. 14 is a graph of a continuous constant amplitude sine wave waveform produced by the circuit shown in FIG. 13;

FIG. 15 is a Krah wave oscillator circuit, one of the constant amplitude sine wave generator circuits, for generating a plurality of sets of periodic time intervals or random time intervals, wherein the inductors are divided into three sets of inductors connected in series, and can be loaded on three magnetic rings or magnetic chains respectively, and actually can be any set of inductors and magnetic ring circuits greater than or equal to 2;

FIG. 16 is a graph of a constant amplitude sine wave waveform at random time intervals produced by the circuit shown in FIG. 15;

FIG. 17 is a constant amplitude sine wave waveform of periodic time intervals produced by the circuit shown in FIG. 15;

FIG. 18 is a Schiller oscillator circuit, another type of constant amplitude sine wave generator circuit for generating a continuous constant amplitude sine wave, in which the inductors are divided into three sets of inductors connected in series, which can be loaded on three magnetic rings or flux linkages, and which can be practically any set of inductors and magnetic ring circuits greater than or equal to 2;

FIG. 19 is a Schiller oscillator circuit, another type of constant amplitude sine wave generator circuit for generating multiple sets of periodic or random time intervals, in which the inductors are divided into three sets of inductors connected in series, which can be loaded on three magnetic rings or flux linkages, and which can be virtually any set of inductors and magnetic ring circuit greater than or equal to 2;

FIG. 20 is a graph of a plurality of sets of periodic time interval amplified sine wave waveforms;

FIG. 21 is a circuit diagram of an arrangement for generating sets of periodic time spaced amplified sinusoidal waveforms as shown in FIG. 20, wherein the inductors are divided into three sets of inductors connected in series, and the inductors can be loaded on three magnetic rings or flux linkages, respectively, and can be virtually any set of inductors and magnetic ring circuit with a period of 2 or more;

FIG. 22 is a schematic diagram of the generation of sets of periodic time spaced amplified sinusoids of FIG. 21;

FIG. 23 is a graph of a plurality of sets of sine wave waveforms with increasing amplitude and decreasing amplitude at periodic intervals;

FIG. 24 is a circuit diagram of a sinusoidal waveform with increasing amplitude followed by decreasing amplitude for the sets of periodic time intervals shown in FIG. 23, in which the inductors are divided into three sets of inductors connected in series, and the inductors can be loaded on three magnetic rings or flux linkages, respectively, and can be virtually any set of inductors and magnetic ring circuit greater than or equal to 2;

FIG. 25 is a schematic diagram of the circuit of FIG. 24 producing sets of periodic time intervals of increasing amplitude followed by decreasing amplitude sine waves of FIG. 23;

FIG. 26 is another circuit diagram of the sinusoidal waveform of FIG. 23 that can be generated by increasing and then decreasing the amplitude of the sets of periodic time intervals, wherein the inductors are divided into three sets of inductors connected in series, and the inductors can be loaded on three magnetic rings or flux linkages, respectively, and can be virtually any set of inductors and magnetic ring circuit that is greater than or equal to 2;

FIG. 27 is a schematic diagram of the circuit of FIG. 26 producing sets of periodic time intervals of increasing amplitude followed by decreasing amplitude sine waves of FIG. 23;

FIG. 28 is a waveform diagram of a frequency modulated continuous FMCW wave;

FIG. 29 is a circuit diagram of the continuous FMCW wave waveform of FIG. 28, wherein the inductors are grouped into three sets of inductors connected in series, which may be loaded onto three magnetic rings or flux linkages, respectively, and which may be substantially any set of inductors and magnetic ring circuits greater than or equal to 2;

FIG. 30 is a schematic diagram of the circuit of FIG. 29 producing the continuous FMCW wave waveform of FIG. 28;

FIG. 31 is a waveform diagram of a frequency modulated continuous FMCW wave;

FIG. 32 is a circuit diagram of the continuous FMCW wave waveform of FIG. 31, wherein the inductors are grouped into three sets of inductors connected in series, which can be loaded onto three magnetic rings or flux linkages, respectively, and which can be virtually any set of inductors and magnetic ring circuits greater than or equal to 2;

FIG. 33 is a schematic diagram of the circuit of FIG. 32 producing the continuous FMCW wave waveform of FIG. 31;

FIG. 34 is a waveform diagram of another frequency modulated continuous FMCW wave;

FIG. 35 is a circuit diagram of the continuous FMCW wave waveform of FIG. 34, wherein the inductors are grouped into three sets of inductors connected in series, which can be loaded onto three magnetic rings or flux linkages, respectively, and which can be virtually any set of inductors and magnetic ring circuits greater than or equal to 2;

FIG. 36 is a schematic diagram of the circuit of FIG. 35 producing the continuous FMCW wave waveform of FIG. 34;

fig. 37 is a schematic structural view of the therapeutic wearing device ofembodiment 2, in which the wearing member has a closed loop structure;

fig. 38 is a schematic structural view of the therapeutic wearing device ofembodiment 2, in which the wearing member has a non-closed loop structure;

fig. 39 is a schematic structural view of a therapeutic wearable device according toembodiment 3;

fig. 40 is a schematic structural view of a therapeutic wearable device according toembodiment 4;

fig. 41 is a schematic structural view of a therapeutic wearable device according toembodiment 5;

fig. 42 is a schematic view of a vest structure of the therapeutic wearable device inembodiment 6;

fig. 43 is a schematic structural view of a brassiere according to wearing equipment for treatment inembodiment 7;

fig. 44 is a schematic structural view of a cap of the therapeutic wearable device inembodiment 8, wherein the magnetic ring array is arc-shaped or circular;

fig. 45 is a schematic view of a cap structure of the therapeutic wearable device inembodiment 8, in which the magnetic ring array is in a spherical arc shape;

fig. 46 is a schematic structural view of the treatment couch of embodiment 9, in which the arc-shaped magnetic ring array is located above the couch plate;

fig. 47 is a schematic structural view of the treatment couch of embodiment 9, in which the arc-shaped magnetic ring array is located below the couch plate;

FIG. 48 is a schematic view showing the structure of the therapeutic bed in accordance with embodiment 9, wherein the bed plate is disposed inside the circular magnetic ring array;

FIG. 49 is a schematic view showing the structure of a treatment couch in accordance with embodiment 10;

FIG. 50 is a schematic view of an alternating electric field generated within a magnetic loop or flux linkage;

FIG. 51 is a schematic representation of the growth and proliferation inhibition of human dermal fibroblasts 3T3 when a device for selectively disrupting or inhibiting mitosis in tumor cells is applied to humandermal fibroblasts 3T 3;

FIG. 52 is a graph showing the inhibition rate of human dermal fibroblasts 3T3 when a device for selectively destroying or inhibiting mitosis of tumor cells is applied to humandermal fibroblasts 3T 3;

FIG. 53 is a schematic illustration of the proliferation assay of human non-small cell lung cancer cells when an apparatus for selectively destroying or inhibiting tumor cell mitosis is applied to human non-small cell lung cancer cells;

FIG. 54 is a graph showing the inhibition rate of a human non-small cell lung cancer cell when an apparatus for selectively destroying or inhibiting mitosis in a tumor cell is applied to the human non-small cell lung cancer cell;

FIG. 55 is a schematic representation of the detection of proliferation of human glioblastoma cells when a device for selectively destroying or inhibiting mitosis in tumor cells is applied to human glioblastoma cells;

FIG. 56 is a graph showing the inhibition rate of human glioblastoma cells when a device for selectively destroying or inhibiting the mitosis of tumor cells is applied to human glioblastoma cells;

FIG. 57 is a schematic representation of the proliferation assay of murine glioma cells when a device for selectively disrupting or inhibiting the mitosis of tumor cells is applied to the murine glioma cells;

FIG. 58 is a graph showing the inhibition rate of murine glioma cells when acted upon by a device for selectively disrupting or inhibiting the mitosis of tumor cells.

Detailed Description

The present invention will be described in detail with reference to the accompanying drawings.

Embodiment 1:

the present embodiment provides a magnetic ring array device for therapy, as shown in fig. 1, including at least two closed magnetic rings ormagnetic chains 1, where each magnetic ring ormagnetic chain 1 is arranged in a sector (as shown in fig. 1 and 2), a circle (as shown in fig. 3 and 4), or a spherical arc (as shown in fig. 5), and then fixed on a fixed support to form a sector, a circle, or a spherical arc magnetic ring array, each magnetic ring ormagnetic chain 1 is wound with at least onemetal coil 2, and eachmetal coil 2 is connected in series and then forms a closed loop with a same alternating signal generating circuit, as shown in fig. 6; preset alternating current is loaded on eachmetal coil 2 through an alternating signal generating circuit, an electric control switch is connected between a VDD power supply and an input end of the alternating signal generating circuit, and the input end of the electric control switch is connected with an output end of the random/periodic signal generating circuit, as shown in fig. 7. Or the alternating signal generating circuit and the VDD power supply are directly connected without being connected with an electric control switch.

When the device is used, in the magnetic ring array, preset alternating electric fields generated in each magnetic ring ormagnetic chain 1 are superposed and converged at one focus. Thecarrier 3 of the cells which are rapidly dividing is placed on a convergence focus of preset alternating electric fields generated in each magnetic ring ormagnetic chain 1 in the magnetic ring array, preset alternating currents are loaded on eachmetal coil 2 through an alternating signal generating circuit, the loaded preset alternating currents can enable the preset alternating electric fields to be generated in the vertical direction of each corresponding magnetic ring ormagnetic chain 1, and all the preset alternating electric fields can generate superposed preset alternating electric fields for destroying or inhibiting the tumor cells which are rapidly dividing.

In the magnetic ring array, the included angle between the preset alternating electric field direction generated in each magnetic ring ormagnetic chain 1 and thecarrier 3 of the tumor cells which are rapidly dividing is more than or equal to 0 degree and less than or equal to 90 degrees, and is preferably 0 degree. The magnetic ring orflux linkage 1 is made of a flexible soft magnetic material or a rigid soft magnetic material. The flexible soft magnetic material is any one or combination of the following materials: electromagnetic pure iron, iron-silicon alloy, iron-nickel alloy, iron-aluminum alloy, iron-silicon-aluminum alloy, iron-cobalt alloy, amorphous soft magnetic alloy and ultra-microcrystalline soft magnetic alloy; the rigid soft magnetic material is any one or combination of the following materials: pure iron and low carbon steel, iron-cobalt alloy, soft magnetic ferrite, amorphous nanocrystalline alloy.

The alternating signal generating circuit needs a power supply circuit, i.e. a switching power supply circuit, as shown in fig. 8, and converts an alternating current commercial power (e.g. 220V 50Hz of the chinese standard) or a battery power into a direct current voltage V through the switching power supply circuit_DDAnd supplies power to the alternating signal generating circuit.

The alternating signal generating circuit is used for generating alternating signals meeting the requirements of frequency, amplitude and time interval. The alternating signal generating circuit can be any one or combination of a constant-amplitude sine wave generator circuit, a reducing-amplitude sine wave generator circuit, an amplifying sine wave generator circuit, a sine wave generator circuit with the amplitude increasing first and then reducing, and a sine wave circuit with the frequency continuously changing between the maximum value and the minimum value.

The constant-amplitude sine wave generator circuit is a Clara wave oscillation circuit or a Mathler oscillation circuit; or, the constant-amplitude sine wave generator circuit mainly comprises a sawtooth wave generator and a voltage-controlled oscillator; or, the constant-amplitude sine wave generator circuit mainly comprises a triangular wave generator and a voltage-controlled oscillator; or, the constant-amplitude sine wave generator circuit mainly comprises a sine wave generator and a voltage-controlled oscillator; the amplitude-reducing sine wave generator circuit is an LC oscillator circuit; the amplification sine wave generator circuit mainly comprises a high-frequency sine wave generator, a sawtooth wave generator and an analog multiplier circuit; the first-to-increase and second-to-decrease sine wave generator circuit mainly comprises a sine wave generator, a triangular wave generator and an analog multiplier circuit, or the first-to-increase and second-to-decrease sine wave generator circuit mainly comprises a high-frequency sine wave generator, a low-frequency sine wave generator and an analog multiplier circuit.

In order to realize the equal time interval or the random time interval among the groups of sine waves, a periodic signal generating circuit, a random signal generating circuit or the combination of the periodic signal generating circuit and the random signal generating circuit is also needed, an electric control switch is also connected between a VDD power supply and the power supply input end of the alternating signal generating circuit, and the output signal of the random/periodic signal generating circuit is used for controlling the electric control switch. The random/periodic signal generating circuit may control the alternating signal generating circuit so as to divide the generated alternating signal into a plurality of series, and the time of occurrence of each series may be periodic, random or continuous.

Two typical damped sine wave generating circuits, as shown in fig. 9 and 11, are LC oscillator circuits incorporating an inductor coil. Fig. 9 is used to generate sets of randomly time-spaced dampened sine waves, and fig. 11 is used to generate sets of periodically time-spaced dampened sine waves. Wherein C in the figure and a primary coil L wound on a magnetic ring or amagnetic chain 1 form an LC oscillator circuit. Because of the presence of a non-negligible parasitic resistance in the inductance L, the LC oscillator is a ringing oscillator with an oscillation frequency of

. The larger the effective series resistance in L, the faster the decay. In fig. 9, the random signal generator generates a random signal, and in fig. 11, the periodic signal generator generates a periodic signal, and the random signal and the periodic signal respectively control the electrically controlled switch (usually implemented by devices such as power MOS transistors, BJT transistors, IGBT transistors, relays, etc.). And the electric control switch is turned off immediately after being turned on, so that the LC oscillator is full of energy and starts to resonate. Thus, the ringing circuit is turned on at random time intervals, forming a ringing sine wave at random time intervals as shown in FIG. 10; the reducing widthThe oscillator circuit is turned on at periodic intervals to form a damped sine wave at periodic intervals as shown in fig. 12. Only three sets of magnetic loop circuits (including three series inductors, three magnetic loops or flux linkages) are shown in fig. 9 and 11, and in fact any set of magnetic loop circuits greater than or equal to 2 may be used. Because the three inductance coils are the same and are in a series structure, the frequency and the amplitude of the current flowing through the three inductance coils are the same.

When the alternating signal generating circuit is a constant-amplitude sine wave generator circuit, the constant-amplitude sine wave generator circuit may be a clara wave oscillating circuit (as shown in fig. 13), which is a sine wave generator circuit combined with an inductor coil for generating a continuous constant-amplitude sine wave as shown in fig. 14. The inductor L can directly adopt themetal coil 2 in the magnetic ring array device for treatment, and if a sine wave generator with other structures, such as a sine wave generated by an RC oscillator, is used for transmitting the sine wave to the primary coil of the transformer, the function of the invention can be realized. The inductors in fig. 13 are divided into three groups of inductors connected in series, and may be loaded on three magnetic rings or magnetic chains respectively, and may be any group of inductors and magnetic ring circuits greater than or equal to 2.

On the basis of the circuit shown in fig. 13, an electronic control switch is added between a VDD power supply and a power supply input terminal of a clara wave oscillating circuit, and a random/periodic signal generating circuit (an output signal of the random/periodic signal generating circuit is used for controlling the electronic control switch) is supplemented, as shown in fig. 15, a random signal or a periodic signal is generated, and the current waveform of the output preset alternating current is a plurality of groups of constant-amplitude sine waves with random time intervals (as shown in fig. 16) or a plurality of groups of constant-amplitude sine waves with periodic time intervals (as shown in fig. 17). The inductors in fig. 15 are divided into three groups of inductors connected in series, and can be loaded on three magnetic rings or magnetic chains respectively, and actually, any group of inductors and magnetic ring circuits with the inductance being greater than or equal to 2 can be used.

When the alternating signal generating circuit is a constant-amplitude sine wave generator circuit, the constant-amplitude sine wave generator circuit may also be a schiller oscillator circuit (as shown in fig. 18), which is a modified capacitance three-point oscillator circuit, and the circuit is a sine wave generator circuit combined with an inductance coil, and is used for generating a continuous constant-amplitude sine wave as shown in fig. 14. The inductor L can directly adopt themetal coil 2 in the magnetic ring array device for treatment. The inductors in fig. 18 are divided into three groups of inductors connected in series, and can be loaded on three magnetic rings or magnetic chains respectively, and actually any group of inductors and magnetic ring circuits with the inductance being more than or equal to 2 can be used.

On the basis of the circuit shown in fig. 18, an electrically controlled switch may be added between the VDD power supply and the power supply input terminal of the schiller oscillator circuit, and a random/periodic signal generating circuit, as shown in fig. 19, may be used to generate a random signal or a periodic signal, so as to output multiple sets of constant-amplitude sine waves at random time intervals (as shown in fig. 16) or multiple sets of constant-amplitude sine waves at periodic time intervals (as shown in fig. 17). The inductors in fig. 19 are divided into three groups of inductors connected in series, and can be loaded on three magnetic rings or magnetic chains respectively, and actually any group of inductors and magnetic ring circuits with the inductance being more than or equal to 2 can be used.

When the magnetic ring array device for treatment in this embodiment is used, the carrier of the cells which are rapidly dividing is placed at the convergence focus of the preset alternating electric field generated in each magnetic ring ormagnetic chain 1 in the magnetic ring array, the alternating current generating circuit is energized to generate the alternating current with the preset frequency and amplitude, when the alternating current is output to eachmetal coil 2, the preset alternating magnetic field is generated in each magnetic ring ormagnetic chain 1, the direction of the alternating magnetic field is the same as the direction of the magnetic ring ormagnetic chain 1, and the alternating magnetic field and the magnetic ring ormagnetic chain 1 form a closed loop. The alternating magnetic field forms an alternating electric field in its vertical direction, i.e. in a direction perpendicular to the plane of the magnetic ring orflux linkage 1. As shown in fig. 50. And because each magnetic ring ormagnetic chain 1 is a magnetic ring array arranged in a sector, a circle or a spherical arc, the preset alternating electric field generated in each magnetic ring ormagnetic chain 1 can converge on a focus, and the carrier of the rapidly dividing cells (usually a patient) is positioned on the focus. Since cells are more susceptible to damage from alternating electric fields having specific frequency and electric field strength characteristics when they are rapidly dividing. Therefore, when the carrier of the rapidly dividing tumor cell is located at the focus of each alternating electric field, the rapidly dividing tumor cell located in the superimposed alternating electric field will be superimposed to generate an alternating voltage, the superimposed alternating voltage will induce a superimposed alternating electric field having the same frequency and the same trend as the alternating current in the coil in the rapidly dividing tumor cell, the rapidly dividing tumor cell can be selectively destroyed by the alternating electric field having the specific frequency and electric field strength characteristics for a period of time, and the normal cell will not be damaged due to the insensitivity to the alternating electric field having the specific frequency and electric field strength characteristics. This selectively destroys rapidly dividing cells like tumor cells without damaging normal cells.

The preset alternating current signal is a sine wave with the frequency within 30 kHz-300 kHz, and the strength of the preset alternating electric field is 0.1V/cm-10V/cm.

The current waveform of the preset alternating current is a continuous constant-amplitude sine wave, and the frequency and the amplitude of the continuous constant-amplitude sine wave are the same, as shown in fig. 14. The alternating signal generating circuits shown in fig. 13 and 18 are both capable of generating a continuous constant amplitude sine wave as shown in fig. 14.

The current waveform of the preset alternating current is a plurality of groups of constant-amplitude sine waves with periodic time intervals, the frequency, the amplitude and the duration of the constant-amplitude sine waves with the periodic time intervals of each group are the same, and the idle time intervals between the constant-amplitude sine waves with the periodic time intervals of two adjacent groups are the same, as shown in fig. 17. The duration of the constant-amplitude sine waves of each group of periodic time intervals is at least one sine wave period; the idle time interval between the constant-amplitude sine waves of the two adjacent groups of period time intervals is at least one sine wave period. The alternating signal generating circuits shown in fig. 15 and 19 are both capable of generating a constant amplitude sine wave with periodic time intervals as shown in fig. 17.

The current waveform of the preset alternating current is a plurality of groups of constant-amplitude sine waves with random time intervals, the frequency of the constant-amplitude sine waves with the random time intervals is the same, the amplitude of the constant-amplitude sine waves with the random time intervals is the same, the duration of the constant-amplitude sine waves with the random time intervals is random, and the idle time intervals between the constant-amplitude sine waves with the random time intervals of two adjacent groups are the same or random, as shown in fig. 16. The duration of each group of constant-amplitude sine waves at random time intervals is at least one sine wave period; the idle time interval between two adjacent groups of constant-amplitude sine waves at random time intervals is at least one sine wave period. The alternating signal generating circuits shown in fig. 15 and 19 are both capable of generating sets of randomly time spaced constant amplitude sine waves as shown in fig. 16.

The current waveform of the preset alternating current is a plurality of groups of amplitude-reducing sine waves with periodic time intervals, the frequency of the amplitude-reducing sine waves with the periodic time intervals of each group is the same, the initial amplitude is the same, the damping attenuation coefficient of the amplitude is the same, and the idle time intervals between the amplitude-reducing sine waves with the periodic time intervals of two adjacent groups are the same; as in fig. 12. After the amplitude-reduced sine wave of each group of periodic time intervals is attenuated to 0, starting the next group of periodic amplitude-reduced sine waves after a fixed idle time interval; the idle time interval between two adjacent groups of amplitude-reduced sine waves with the period time interval is at least one sine wave period; the attenuation coefficient of the damped sine waves of each group of periodic time intervals is R/2L, wherein R is the series resistance value or the equivalent series parasitic resistance value of the LC oscillating circuit, L is the inductance of the LC oscillating circuit, and C is a capacitance value connected in parallel to the inductance L; the duration of each group of the amplitude-reduced sine waves is 5-30 sine wave periods. By changing the resistance value R, the attenuation coefficient can be changed. The sine wave attenuation coefficient (equivalent to the series resistance value R of the regulating inductor L) can be preset according to the position of a patient and the severity of the disease. The alternating signal generating circuit shown in fig. 11 can generate a plurality of sets of amplitude-reduced sine waves of equal time interval periodic time intervals as shown in fig. 12.

The current waveform of the preset alternating current is a plurality of groups of amplitude-reduced sine waves with random time intervals, the frequency of the amplitude-reduced sine waves with random time intervals in each group is the same, the starting amplitudes are the same or different, the attenuation coefficients are the same or different, and the idle time intervals between two adjacent groups of the amplitude-reduced sine waves with random time intervals are random, as shown in fig. 10. The attenuation coefficient of each group of the damped sine waves at random time intervals is R/2L, wherein R is the series resistance value or the equivalent series parasitic resistance value of the LC oscillating circuit, L is the inductance of the LC oscillating circuit, and C is a capacitance value connected in parallel to the inductance L; the duration of each group of the amplitude-reduced sine waves at random time intervals is 5-30 sine wave periods. By changing the resistance value R, the attenuation coefficient can be changed. The decay system is usually evaluated simply by how many sustained sinusoids per group. The sine wave attenuation coefficient (which is equivalent to the series resistance value R of the regulating inductor L) can be set according to the position of a patient and the severity of the disease. An alternating signal generating circuit as shown in figure 9, i.e. capable of generating sets of randomly time spaced reduced sine waves as shown in figure 10.

The current waveform of the preset alternating current is a plurality of groups of amplified sine waves with periods or random time intervals or continuous amplitudes gradually increased, the frequency of each group of amplified sine waves is the same, the amplitudes are gradually increased, and the idle time intervals between two adjacent groups of amplified sine waves are the same or random. The duration of each group of amplified sine waves is 5-30 sine wave periods. The circuit shown in fig. 21 comprises a high-frequency sine wave generator, a sawtooth wave generator and an analog multiplier circuit, wherein the analog multiplier circuit is connected with all serially connected inductance coils as loads through power amplifiers, and the inductance coils can directly adopt themetal coils 2 in the magnetic ring array device for treatment. By multiplying the high-frequency sine wave generated by the high-frequency sine wave generator and the sawtooth wave generated by the sawtooth wave generator, a plurality of sets of amplified sine waves with periodic time intervals of gradually increasing amplitude are obtained as shown in fig. 20. The waveform generation principle is shown in fig. 22. The periodic time interval amplified sine wave current is then loaded into therespective metal coil 2. The inductors in fig. 21 are divided into three groups of inductors connected in series, and may be loaded on three magnetic rings or magnetic chains respectively, and may be any group of inductors and magnetic ring circuits with 2 or more.

The current waveform of the preset alternating current is a plurality of groups of periodic or random time intervals or continuous amplitude values, wherein the amplitude values of each group are increased firstly and then decreased by sine waves, the frequency of each group of amplitude values is the same, the amplitude values are gradually increased firstly and then gradually decreased, and the idle time intervals between the groups of amplitude values, which are increased firstly and then decreased by sine waves, are the same or random. The circuit shown in fig. 24 is a circuit for generating a plurality of sets of sine wave waveforms with increasing amplitude and then decreasing amplitude of the periodic time intervals shown in fig. 23, and comprises a high-frequency sine wave generator, a low-frequency sine wave generator and an analog multiplier circuit, wherein the analog multiplier circuit is connected with all serially connected inductance coils through power amplifiers to serve as loads, and the inductance coils can directly adopt themetal coils 2 in the magnetic ring array device for treatment. The high-frequency sine wave generated by the high-frequency sine wave generator is multiplied by the low-frequency sine wave generated by the low-frequency sine wave generator, so that a plurality of groups of sine waves with the amplitude increasing first and then decreasing second at periodic time intervals are obtained, and the waveform generation principle is shown in fig. 25, wherein the amplitude of the periodic time intervals is gradually increased and then is gradually decreased as shown in fig. 23. The inductors in fig. 24 are divided into three groups of inductors connected in series, and can be loaded on three magnetic rings or magnetic chains respectively, and actually any group of inductors and magnetic ring circuits with the inductance being more than or equal to 2 can be used.

The circuit shown in fig. 26 is another circuit for generating a plurality of groups of sine wave waveforms with the periodic time intervals of which the amplitudes are increased and then decreased as shown in fig. 23, and comprises a high-frequency sine wave generator, a triangular wave generator and an analog multiplier circuit, wherein the analog multiplier circuit is connected with all serially connected inductance coils as loads through power amplifiers, and the inductance coils can directly adopt themetal coils 2 in the magnetic ring array device for treatment. The high-frequency sine wave generated by the high-frequency sine wave generator is multiplied by the triangular wave generated by the triangular wave generator, so that the sine wave with the amplitude increasing and then decreasing at the periodic time interval of the plurality of groups of the amplitude increasing and then decreasing gradually is obtained as shown in fig. 23. The waveform generation principle is shown in fig. 27. The circuit for generating the sine wave waveforms of the sets of periodic time intervals shown in fig. 23, which are increased in amplitude and then decreased in amplitude, is not limited to the circuits shown in fig. 24 and 26. The inductors in fig. 26 are divided into three groups of inductors connected in series, and can be loaded on three magnetic rings or magnetic chains respectively, and actually any group of inductors and magnetic ring circuits with the inductance being more than or equal to 2 can be used.

The current waveform of the preset alternating current is similar to a frequency modulated continuous FMCW wave, the frequency of the frequency modulated continuous FMCW wave increases linearly within a preset time, and then decreases linearly within the preset time, as shown in fig. 28. The starting frequency and the final frequency are both within a preset range of 30 KHz-300 KHz, the maximum limit value of the highest frequency is 300kHz, and the minimum limit value of the lowest frequency is 30 kHz. In a certain device, the highest frequency and the lowest frequency are selected and set according to specific cancer cell attributes, but always fall within the range of 30 KHz-300 KHz. A preset time interval is arranged between the highest frequency and the lowest frequency; the duration of the linear increase from the lowest frequency to the highest frequency is 5-100 sine wave periods.

Fig. 29 is a circuit diagram for generating the continuous FMCW wave waveform of fig. 28. The magnetic ring array device for the treatment comprises a triangular wave generator and a voltage-controlled oscillator, wherein the voltage-controlled oscillator is connected with all serially connected inductance coils through a power amplifier to serve as loads, and the inductance coils can directly adopt ametal coil 2 in the magnetic ring array device for the treatment. The triangular wave voltage generated by the triangular wave generator is used for controlling the voltage-controlled oscillator, and the output frequency can be a sine wave with continuous change but constant amplitude, namely a continuous FMCW wave. The preset time interval between the highest frequency and the lowest frequency depends on the frequency of the triangular wave. The schematic diagram of the waveform generation is shown in fig. 30. The inductors in fig. 29 are divided into three groups of inductors connected in series, and can be loaded on three magnetic rings or magnetic chains respectively, and actually any group of inductors and magnetic ring circuits with the inductance being more than or equal to 2 can be used.

The current waveform of the preset alternating current is similar to a frequency modulated continuous FMCW wave, and the frequency of the frequency modulated continuous FMCW wave is linearly increased from the lowest frequency to the highest frequency, then rapidly decreased to the lowest frequency, and then linearly increased from the lowest frequency to the highest frequency within the pulse duration, and the process is repeated, as shown in fig. 31. The starting frequency and the final frequency are both within a preset range of 30 KHz-300 KHz, the limit value of the highest frequency is 300kHz, and the limit value of the lowest frequency is 30 kHz. In a certain device, the highest frequency and the lowest frequency are selected and set according to specific cancer cell attributes, but always fall within the range of 30 KHz-300 KHz. A preset time interval is arranged between the highest frequency and the lowest frequency; the duration of the linear increase from the lowest frequency to the highest frequency is 5-100 sine wave periods.

Fig. 32 is a circuit diagram for generating the continuous FMCW wave waveform of fig. 31. The magnetic ring array device for the treatment comprises a sawtooth wave generator and a voltage-controlled oscillator, wherein the voltage-controlled oscillator is connected with all serially connected inductance coils through a power amplifier to serve as loads, and the inductance coils can directly adopt ametal coil 2 in the magnetic ring array device for the treatment. The sawtooth wave voltage generated by the sawtooth wave generator is used for controlling the voltage-controlled oscillator, and the sine wave with continuously variable frequency and constant amplitude is output, namely the continuous FMCW wave with frequency modulation. The preset time interval between the highest frequency and the lowest frequency depends on the frequency of the sawtooth wave. The schematic diagram of the waveform generation is shown in fig. 33. The inductors in fig. 32 are divided into three groups of inductors connected in series, and may be loaded on three magnetic rings or magnetic chains respectively, and may be any group of inductors and magnetic ring circuits with 2 or more.

The current waveform of the preset alternating current is similar to a frequency modulated continuous FMCW wave, the frequency of the frequency modulated continuous FMCW wave is increased and then decreased at a preset time, and the change of the increased and decreased frequency conforms to a sine wave rule, as shown in fig. 34. The starting frequency and the final frequency are both within a preset range of 30 KHz-300 KHz, the limit value of the highest frequency is 300kHz, and the limit value of the lowest frequency is 30 kHz. In a certain device, the highest frequency and the lowest frequency are selected and set according to specific cancer cell attributes, but always fall within the range of 30 KHz-300 KHz. A preset time interval is arranged between the highest frequency and the lowest frequency; the duration of the linear increase from the lowest frequency to the highest frequency is 5-100 sine wave periods.

Fig. 35 is a circuit diagram for generating the FMCW waveform of fig. 34. The therapeutic magnetic ring array device comprises a sine wave generator and a voltage-controlled oscillator, wherein the voltage-controlled oscillator is connected with all serially connected inductance coils through a power amplifier to serve as loads, and the inductance coils can directly adopt themetal coils 2 in the therapeutic magnetic ring array device. The sine wave voltage generated by the sine wave generator is used for controlling the voltage-controlled oscillator, and the sine wave with continuously variable frequency and constant amplitude is output, namely the frequency modulation continuous FMCW wave. The preset time interval between the highest frequency and the lowest frequency depends on the frequency of the low frequency sine wave. The schematic diagram of the waveform generation is shown in fig. 36. In fig. 35, the inductors are divided into three groups of inductors connected in series, and may be respectively loaded on three magnetic rings or magnetic chains, and may be actually any group of inductors and magnetic ring circuits greater than or equal to 2.

In the embodiment, an alternating electric field with the frequency of 30 kHz-300 kHz and the alternating electric field with the intensity of 0.1V/cm-10V/cm is applied to normal cells and different tumor cell lines, so that the device in the embodiment can selectively kill tumor cells and inhibit the growth of the tumor cells by adding the field intensity with the specific frequency (between 30kHz and 300 kHz) and the intensity (between 0.1V/cm and 10V/cm). The experimental method is as follows:

normal cells, human skin fibroblast 3T3, three cancer cells, human lung adenocarcinoma cell a549, human glioblastoma cell U87 and murine glioma cell C6 were inoculated in 96-well plates, respectively. The experimental group places the cells in magnetic rings generating electric fields with different electric field strengths and different frequencies, places the magnetic ring array and the cells in a carbon dioxide incubator with the volume of 54 multiplied by 50 multiplied by 68cm, the incubator is grounded, the internal self electric field strength is 0, and no influence of an external electric field exists; the control group was cultured in the same incubator routinely without electric field. The cells of the experimental group and the cells of the control group are inoculated in the same quantity and the same density, the culture conditions are DEME +10% FBS culture medium, the cells are cultured for 1 to 14 days, the CCK8 cell proliferation experiment detection is carried out, and the cell proliferation inhibition rate is calculated.

The experimental results are as follows:

when the electric field intensity range is 0.1V/cm-10V/cm and the frequency is 30 kHz-300 kHz, the inhibition results on the proliferation of normal cells and three different tumor cells are as follows:

1, effect on normal cells:

in the present embodiment, human skin fibroblasts 3T3 were cultured in the alternating electric field environment (test group/experimental group) and in the normal culture environment (control group/control group), respectively, and the proliferation and inhibition of the alternating electric field on the growth of human skin fibroblasts 3T3 were examined, with the results expected: the alternating electric field has no obvious influence on the growth and proliferation of human skin fibroblast 3T3, and the cell proliferation of the experimental group is consistent with that of the control group, as shown in figure 51. The inhibition rate of the alternating electric field on the growth of the human skin fibroblast 3T3 is close to 0, and no obvious proliferation inhibition effect exists, as shown in figure 52.

2, cell proliferation inhibition by applying electric field to human lung adenocarcinoma cells

As shown in fig. 53 and 54, for human lung adenocarcinoma cells a549, the inhibition rate was about 60% when the inhibition effect was the best, i.e., the number of cells inhibited was 60% of the total number of cells in the control group.

3, cell proliferation inhibition by applying electric field to human glioblastoma cells

As shown in fig. 55 and 56, for the human glioblastoma cell U87, the inhibition rate was about 53% when the inhibition effect was the best, i.e., the number of cells inhibited was 53% of the total number of cells in the control group.

Inhibition of cell proliferation by applying electric field to rat glioma cells

As shown in fig. 57 and 58, for murine glioma cell C6, the inhibition rate was 0.65 when the inhibition effect was the best, i.e., the number of cells inhibited was 65% of the total number of cells in the control group.

Embodiment 2:

according to the device inembodiment 1, this embodiment provides a therapeutic magnetic ring array wearable device, which may be in the shape of a bracelet, a foot ring, a neck ring, an arm bag, an abdominal belt or a waistband, as shown in fig. 37, and includes awearable component 4 in the shape of a bracelet, a foot ring, a neck ring, an arm bag, an abdominal belt or a waistband, and the therapeutic magnetic ring array device inembodiment 1, in this case, the magnetic ring array in the therapeutic magnetic ring array device may be in the shape of a sector as shown in fig. 1 or a circle as shown in fig. 3. Thewearable component 4 is an annular structure which is made of ABS, HDPE, PC, FRP, fiber, nylon, rubber or silica gel materials and is not closed or closed end to end, the magnetic ring array is installed on the outer side wall of thewearable component 4, a clampinggroove 401 is formed in the side wall of thewearable component 4, and the magnetic ring array is clamped in the clampinggroove 401 to realize the installation connection with thewearable component 1; the alternating signal generating circuit is mounted in ahousing 8 which is fixed to the wearingunit 4.

When using this bracelet, anklet, neck ring, arm package, binder or waistband, if wear the subassembly and be closed annular structure, like fig. 37, then directly through wearingsubassembly 4 with bracelet, anklet, neck ring, arm package, binder or waistband cover on patient's arm, ankle, neck, waist or belly can. If wearingsubassembly 4 for the not closed loop configuration of end to end, like fig. 38, then cover bracelet, foot ring, neck ring, arm package, binder or waistband on patient's arm, ankle, neck, waist or behind the belly through wearing the subassembly, it can to pass throughbuckle 402 with the both ends of wearingsubassembly 4 and connect.

When tumor cells exist in the arms, legs, necks, waists, abdomens or pelvic cavities of a patient, the patient only needs to wear the bracelet, the ankles, the neckloop, the waistbands, the buttocks bag or the abdominal belt, and then selects the current waveform of the preset alternating current with proper frequency and amplitude through the alternating signal generating circuit according to the specific situation of the tumor.

Otherwise, this embodiment is identical toembodiment 1, and will not be described herein.

Embodiment 3:

this embodiment is substantially the same asembodiment 2, and is different only in the connection form between the magnet ring array and the wearingunit 4 in this embodiment. In this embodiment, the side wall of the wearingcomponent 4 is provided with abinding mechanism 403, and the wearingcomponent 4 and the magnetic ring array are bound together through thebinding mechanism 403. Thebinding mechanism 403 is a plurality of pairs of circumferential laces disposed on the sidewall of the wearingcomponent 4, one end of each pair of laces is fixed on the sidewall of the wearingcomponent 4, and the other end of each pair of laces is tied on the magnetic ring array. As in fig. 39.

Otherwise, this embodiment is identical toembodiment 2, and will not be described herein.

Embodiment 4:

this embodiment is substantially the same asembodiment 3, except that the binding means 403 of the wearingunit 4 in this embodiment is a plurality of pairs of hidden button groups circumferentially provided on the side wall of the wearingunit 4, the plurality of pairs of hidden button groups are fixed to the side wall of the wearingunit 4 through connecting members, and the wearingunit 4 can be attached to the magnetic ring array through each pair of hidden button groups. As shown in fig. 40.

Otherwise, this embodiment is completely the same asembodiment 3, and will not be described herein.

Embodiment 5:

this embodiment is substantially the same asembodiment 2, and is different only in the connection form between the magnet ring array and the wearingunit 4 in this embodiment. In this embodiment, the wearingcomponent 4 may be a housing made of fiber, nylon, rubber or silica gel material directly wrapped outside the magnetic ring array. As in fig. 41.

Otherwise, this embodiment is identical toembodiment 2, and will not be described herein.

Embodiment 6:

according to the device inembodiment 1, this embodiment provides a therapeutic wearable device, as shown in fig. 42, the wearable device may be in the shape of a vest, the wearable device includes awearable component 4 in the shape of a vest and the therapeutic magnetic ring array device inembodiment 1, in this case, the magnetic ring array in the therapeutic magnetic ring array device may also be in the shape of a sector as shown in fig. 1 or a circle as shown in fig. 3. The wearingcomponent 4 is made of ABS, HDPE, PC, FRP, fiber, nylon, rubber or silica gel material in a vest shape, the magnetic ring array is sewn on the outer sidewall of the wearingcomponent 4, or the connection relationship between the magnetic ring array and the wearingcomponent 4 may be the same as any one ofembodiments 2 to 5; the alternating signal generating circuit is mounted in ahousing 8 which is fixed to the wearingunit 4.

The vest is used when tumors exist in the chest, abdomen or back of a patient, and can be used for treating lung cancer, esophageal cancer, mediastinal tumor, liver cancer, stomach cancer, pancreatic cancer, kidney cancer and the like. The patient only needs to wear the vest and then selects the current waveform of the preset alternating current with proper frequency and amplitude through the alternating signal generating circuit according to the specific condition of the tumor.

Otherwise, this embodiment is identical toembodiment 1, and will not be described herein.

Embodiment 7:

according to the apparatus ofembodiment 1, this embodiment provides a therapeutic wearable device, which may be in the shape of a bra as shown in fig. 43, and includes a bra-shapedwearable component 4 and the therapeutic magnetic ring array apparatus ofembodiment 1 disposed at the positions of nipples on both sides of the bra, in which case, the magnetic ring array in the therapeutic magnetic ring array apparatus may be circular as shown in fig. 3. The wearingcomponent 4 is made of ABS, HDPE, PC, FRP, fiber, nylon, rubber or silica gel material into a bra shape, the magnetic ring array is sewn on the outer sidewall of the wearingcomponent 4, or the connection relationship between the magnetic ring array and the wearingcomponent 4 may be the same as any ofembodiments 2 to 5; the alternating signal generating circuits are each mounted in ahousing 8 which is fixed to the wearingunit 4.

When a tumor such as breast cancer exists in the chest of a patient, the bra is worn by the patient, and then the current waveform of the preset alternating current with proper frequency and amplitude is selected through the alternating signal generating circuit according to the specific condition of the tumor.

Otherwise, this embodiment is identical toembodiment 1, and will not be described herein.

Embodiment 8:

according to the apparatus inembodiment 1, this embodiment provides a therapeutic wearable device, as shown in fig. 44, the wearable device may be in a hat or helmet shape, the wearable device includes a hat or helmet-shapedwearable component 4 and the therapeutic magnetic ring array apparatus inembodiment 1, in this case, the magnetic ring array in the therapeutic magnetic ring array apparatus may be in a fan shape as shown in fig. 1 or in a circular shape as shown in fig. 3. Or the wearing device is as shown in fig. 45, in this case, the magnetic ring array in the therapeutic magnetic ring array device may be a spherical arc as shown in fig. 5. The wearingcomponent 4 is made of ABS, HDPE, PC, FRP, fiber, nylon, rubber or silica gel material in the shape of a hat or helmet, the magnetic ring array is sewn on the outer sidewall of the wearingcomponent 4, or the connection relationship between the magnetic ring array and the wearingcomponent 4 may be the same as any ofembodiments 2 to 5; the alternating signal generating circuits are each mounted in ahousing 8 which is fixed to the wearingunit 4.

When tumor cells such as glioma exist on the head of a patient, the cap or helmet is used, the patient only needs to wear the cap or helmet, and then the alternating signal generating circuit selects the current waveform of the preset alternating current with proper frequency and amplitude according to the specific situation of the tumor.

Otherwise, this embodiment is identical toembodiment 1, and will not be described herein.

Embodiment 9:

according to the device inembodiment 1, this embodiment provides a therapeutic bed, which includes abed plate 5, a positioning assembly, and a magnetic ring array device for therapeutic use inembodiment 1, in which a magnetic ring array is mounted on apositioning frame 6 in the positioning assembly, the magnetic ring array may be fan-shaped as shown in fig. 1, or circular as shown in fig. 3, or spherical arc as shown in fig. 5. The magnetic ring array is located above (as shown in fig. 46) and below (as shown in fig. 47) thebed plate 5 or the bed plate is located in the magnetic ring array (as shown in fig. 48), thebed plate 5 is located at a focal position where preset alternating electric fields generated in each magnetic ring ormagnetic chain 1 in the magnetic ring array are superposed and converged, and a plane where the magnetic ring array is located is perpendicular to a plane where thebed plate 5 is located. The alternating signal generating circuits are each mounted in ahousing 8 which is fixed to the wearingunit 4.

When the treatment bed is used, a patient directly lies on thebed plate 5, and then the current waveform of the preset alternating current with proper frequency and amplitude is selected through the alternating signal generating circuit according to the specific condition of the tumor. The treatment bed can be suitable for treating various tumors.

Otherwise, this embodiment is identical toembodiment 1, and will not be described herein.

Embodiment 10:

the present embodiment is a further improvement of embodiment 9, and a main improvement is that, in the present embodiment, in order to enable a relative position between the magnetic ring array and the bed plate to be adjustable, so that a focal position of the superimposed alternating electric field generated in each magnetic ring ormagnetic chain 1 in the magnetic ring array is adjustable relative to thebed plate 5, so as to facilitate treatment of diseases at different positions of the body of the patient lying on thebed plate 5, the treatment couch in the present embodiment further includes a position adjusting mechanism, the position adjusting mechanism includes anX-axis slide rail 501 fixed on one side of thebed plate 5, a bottom of thepositioning frame 6 is slidably connected with theX-axis slide rail 501 through afirst slide block 601, a Y-axis slide rail 603 perpendicular to theX-axis slide rail 501 is installed on across beam 602 of thepositioning frame 6, and a fixingsupport 7 of the magnetic ring array is slidably connected with the Y-axis slide rail 603 through asecond slide block 8. As in fig. 49. When the adjustment is needed, the magnetic ring array is pushed to move along theX-axis slide rail 501 in the X-axis direction by pushing thepositioning frame 6, and the magnetic ring array is pushed to move along the Y-axis slide rail 603 in the Y-axis direction, so that the purpose that the focus position of the superposed alternating electric field generated in each magnetic ring or eachmagnetic chain 1 in the magnetic ring array is adjustable relative to thebed plate 5 is achieved, and the application range of the treatment bed is wider.

Otherwise, this embodiment is completely the same as embodiment 9, and will not be described herein.

It should be understood that the magnetic ring array device for treatment in the present invention can be used for other purposes besides treating tumors in living bodies. In fact, selective disruption using the present device may be used in conjunction with any proliferation dividing and propagating organism, for example, tissue cultures, microorganisms such as bacteria, mycoplasma, protozoa, etc., fungi, algae, plant cells, etc.

Tumor cells as presented herein include leukemia, lymphoma, myeloma, plasmacytoma; and solid tumors. Examples of solid tumors that may be treated according to the present invention include sarcomas and carcinomas such as, but not limited to: fibrosarcoma, myxosarcoma, liposarcoma, chondrosarcoma, osteogenic sarcoma, dorsal-locked epithelioma, angiosarcoma, endotheliosarcoma, lymphangiosarcoma, lymphangioendothelioma, synovioma, mesothelioma, leiomyosarcoma, rhabdomyosarcoma, colon cancer, pancreatic cancer, breast cancer, ovarian cancer, prostate cancer, squamous cell carcinoma, basal cell carcinoma, adenocarcinoma, sweat gland carcinoma, sebaceous gland carcinoma, papillary adenocarcinoma, cystadenocarcinoma, medullary carcinoma, bronchial carcinoma, renal cell carcinoma, liver cancer, bile duct carcinoma, choriocarcinoma, seminoma, embryonic carcinoma, cervical cancer, testicular tumor, lung cancer, small-cell lung cancer, bladder cancer, epithelial cancer, glioma, astrocytic carcinoma, medulloblastoma, craniopharyngioma, ependymoma, pinealoma, hemangioblastoma, acoustic neuroma, oligoglioma, meningioma, melanoma, neuroblastoma, melanoma, neuroblastoma, melanoma, neuroblastoma, melanoma, neuroblastoma, melanoma, neuroblastoma, melanoma, carcinoma of the patient's nerve, or other cell of the patient's nerve, or of the patient's skin, or the patient's skin, Neuroblastoma and retinoblastoma.

The above embodiments are merely illustrative of the technical concepts and features of the present invention, and the purpose of the embodiments is to enable those skilled in the art to understand the contents of the present invention and implement the present invention, and not to limit the protection scope of the present invention. All equivalent changes and modifications made according to the spirit of the present invention should be covered within the protection scope of the present invention.

Claims (10)

1. A magnetic ring array device for treatment is characterized by comprising at least two closed magnetic rings or magnetic chains (1), wherein the magnetic rings or magnetic chains (1) are arranged into a fan shape, a circular shape or a spherical arc shape and then are fixed on a fixed support (7) to form a magnetic ring array, at least one metal coil (2) is wound on each magnetic ring or magnetic chain (1), and the metal coils are connected in series and then form a closed loop with the same alternating signal generating circuit; in the magnetic ring array, preset alternating electric fields generated in each magnetic ring or magnetic chain (1) are superposed and converged at a focus;

the alternating signal generating circuit is any one of the following: a constant-amplitude sine wave generator circuit, a reducing sine wave generator circuit, an amplifying sine wave generator circuit, a sine wave generator circuit with amplitude increasing and then reducing, and a sine wave circuit with frequency continuously changing between the maximum value and the minimum value; wherein, the inductance in each sine wave generator circuit is the metal coil (2);

and a preset alternating current with the signal frequency of a current waveform of 30 kHz-300 kHz is loaded on each metal coil (2) through the alternating signal generating circuit, the preset alternating current can enable a preset alternating magnetic field to be generated in the corresponding magnetic ring or magnetic chain (1), and the preset alternating magnetic field can form a preset alternating electric field which can destroy or inhibit the rapidly dividing tumor cells in the carrier and has the intensity of 0.1V/cm-10V/cm and does not act on normal cells in the direction perpendicular to the corresponding magnetic ring or magnetic chain (1).

2. A therapeutic magnetic ring array device as claimed in claim 1, further comprising a random/periodic signal generating circuit, an electrically controlled switch being connected between the VDD power supply and the input of said alternating signal generating circuit, an output signal of said random/periodic signal generating circuit being used to control said electrically controlled switch.

3. A therapeutic magnetic ring array device as claimed in claim 1 or 2, wherein said constant amplitude sine wave generator circuit is a clara wave oscillator circuit or a soller oscillator circuit, and the current waveform of said preset alternating current outputted is a continuous constant amplitude sine wave, a plurality of sets of periodic time interval constant amplitude sine waves or a plurality of sets of random time interval constant amplitude sine waves.

4. A magnetic ring array device for therapeutic use according to claim 1 or 2, wherein said constant amplitude sine wave generator circuit mainly comprises a sawtooth wave generator and a voltage controlled oscillator, said sawtooth wave generator generates sawtooth wave voltage to control said voltage controlled oscillator, and said preset alternating current output has current waveform similar to frequency modulated continuous FMCW wave, multiple sets of FMCW waves with periodic time interval or multiple sets of FMCW waves with random time interval.

5. A therapeutic magnetic ring array device according to claim 1 or 2, characterized in that said constant-amplitude sine wave generator circuit mainly comprises a triangular wave generator and a voltage controlled oscillator, said voltage controlled oscillator uses said serially connected metal coils (2) as load;

the triangular wave voltage generated by the triangular wave generator controls the voltage-controlled oscillator, and the output current waveform of the preset alternating current is similar to a frequency modulation continuous FMCW wave, multiple groups of FMCW waves with periodic time intervals or multiple groups of FMCW waves with random time intervals.

6. A therapeutic magnetic ring array device according to claim 1 or 2, characterized in that said constant-amplitude sine wave generator circuit mainly comprises a sine wave generator and a voltage controlled oscillator, said voltage controlled oscillator having said series-connected metal coils (2) as a load;

the sine wave voltage generated by the sine wave generator controls the voltage-controlled oscillator, and the current waveform of the output preset alternating current is similar to a frequency modulation continuous FMCW wave, multiple groups of FMCW waves with periodic time intervals or multiple groups of FMCW waves with random time intervals.

7. A therapeutic magnetic ring array device as claimed in claim 1 or 2, wherein said amplitude-reduced sine wave generator circuit is an LC oscillator circuit, and the current waveform of said preset alternating current outputted is a continuous amplitude-reduced sine wave, a plurality of sets of periodic time interval amplitude-reduced sine waves or a plurality of sets of random time interval amplitude-reduced sine waves.

8. A therapeutic magnetic ring array device as claimed in claim 1 or 2, wherein said amplified sine wave generator circuit mainly comprises a high frequency sine wave generator, a sawtooth wave generator and an analog multiplier circuit, said analog multiplier circuit using said serially connected metal coils (2) as a load;

and multiplying the high-frequency sine wave generated by the high-frequency sine wave circuit by the sawtooth wave generated by the sawtooth wave generator, wherein the output current waveform of the preset alternating current is a continuous amplification sine wave, multiple groups of amplification sine waves with periodic time intervals or multiple groups of amplification sine waves with random time intervals.

9. A therapeutic magnetic ring array device as claimed in claim 1 or 2, wherein said increase-first-decrease sine wave generator circuit mainly comprises a high frequency sine wave generator, a low frequency sine wave generator and an analog multiplier circuit, said analog multiplier circuit using said serially connected metal coils (2) as a load;

and multiplying the high-frequency sine wave generated by the high-frequency sine wave generator by the low-frequency sine wave generated by the low-frequency sine wave generator, wherein the output current waveform of the preset alternating current is that the amplitude is increased and then reduced by a continuous sine wave, the amplitudes of a plurality of groups of periodic time intervals are increased and then reduced by a sine wave or the amplitudes of a plurality of groups of random time intervals are increased and then reduced by a sine wave.

10. A therapeutic magnetic ring array device as claimed in claim 1 or 2, wherein said first increase and then decrease sine wave generator circuit mainly comprises a high frequency sine wave generator, a triangle wave generator and an analog multiplier circuit, said analog multiplier circuit using said serially connected metal coils (2) as load;

and multiplying the high-frequency sine wave generated by the high-frequency sine wave generator by the triangular wave generated by the triangular wave generator, wherein the output current waveform of the preset alternating current is the sine wave with the amplitude increased and then reduced, the sine wave with the amplitude increased and then reduced at a plurality of groups of periodic time intervals, or the sine wave with the amplitude increased and then reduced at a plurality of groups of random time intervals.

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