CN113521042A - Alcohol-free wash-free virus inactivation disinfectant special for children and preparation method thereof - Google Patents

Abstract

The invention relates to the technical field of sanitary disinfectants, and discloses an alcohol-free no-wash virus inactivation disinfectant special for children, which comprises the following components: the disinfectant comprises a cationic bactericide, a cationic surfactant or a zwitterionic surfactant, an aldehyde bactericide, a synergist, a skin-care humectant, a neutralizer, a solubilizer, a thickener, a pH regulator, a pH value regulating system of which is 7.2-8.2 and pure water; also discloses a preparation method. The invention has stable performance, high-efficiency and quick disinfection, no washing, fresh and cool hand feeling without stickiness after use, simple preparation process, capability of meeting the requirement of cleaning and disinfection of hands of children anytime and anywhere, capability of quickly killing common pathogenic bacteria and viruses on the surface of skin, broad-spectrum and strong effects of killing bacteria and viruses, good endurance, capability of reducing 80 percent of pathogenic bacteria infection probability, no potential health risk, good moisturizing and skin care effects, and capability of overcoming dry, chapped and allergic skin and other adverse side effects caused by long-term use.

Description

Alcohol-free wash-free virus inactivation disinfectant special for children and preparation method thereof

Technical Field

The invention relates to the technical field of sanitary disinfectants, in particular to an alcohol-free no-clean virus inactivation disinfectant special for children and a preparation method thereof.

Background

In a plurality of body organs, the hand is the most frequent part of the human body contacting the outside, various bacteria are easily infected in daily work and life, particularly children lack of sanitation and cleanness consciousness, and the judgment capability and the self-protection capability on the environment polluted by the bacteria and viruses are not realized. The hand-foot-and-mouth disease mainly occurs to infants, mainly occurs to children 3 to 6 years old in the early school age of a kindergarten, and the proportion of the people suffering from the hand-foot-and-mouth disease is the highest in children under 5 years old. Research shows that 30-40% of drug-resistant bacteria infection is caused by improper hand hygiene. Foreign studies have shown that by enhancing hand hygiene, the infection rate can be reduced by 30%. However, the pathogenic microorganisms can not be completely removed by only washing hands, and a plurality of pathogenic microorganisms on the skin of the hands can be quickly and effectively killed by using a proper hand disinfectant. At present, with the continuous development of hand hygiene products, more and more hand disinfection liquid products are available in the market, the components and the performances of the hand disinfection liquid products are different, and the sterilization effect is different. Although the hand disinfectants on the market are various, ideal disinfectants for children are difficult to find.

The skin of children and infants is very delicate and sensitive. The hand sanitizer for children and infants is safe, has reliable effects of disinfecting and killing microorganisms and viruses, and can be used for cleaning mouths, hands and things which the hands and mouths of babies may contact. An ideal hand sanitizer needs to be highly effective and low in toxicity. At present, any single chemical substance has certain limitation, and a complex formulation mode is generally adopted to pursue a relatively ideal effect, so the inventor invents the special alcohol-free no-wash virus inactivation disinfectant for children and the preparation method thereof.

Disclosure of Invention

Based on the problems, the invention provides the special alcohol-free no-wash virus inactivation disinfectant for children and the preparation method thereof, the alcohol-free no-wash virus inactivation disinfectant for children, which is prepared by compounding the cation bactericide and the aldehyde bactericide to prepare the alcohol-free no-wash disinfectant for children, takes the compound cation bactericide, the aldehyde bactericide and the sterilization synergist to be compounded as main sterilization components, has stable performance, can rapidly sterilize and kill viruses, has high efficiency, low toxicity, no alcohol and safety, and can prevent dry and chap hand skin caused by long-term use by adding the effective skin care components.

In order to solve the technical problems, the invention provides an alcohol-free no-wash virus inactivation disinfectant special for children, which comprises the following components in percentage by mass: 0.05-2% of cationic bactericide, 0.0005-0.02% of cationic surfactant or zwitterionic surfactant, 0.01-1% of aldehyde bactericide, 0.05-2% of synergist, 0.1-5% of skin-care humectant, 0.2-2% of neutralizer, 1-10% of solubilizer, 0.05-3% of thickener, pH value of pH regulator adjusting system of 7.2-8.2, and the balance of pure water.

Further, the cationic bactericide is any one or more of chlorhexidine gluconate, chlorhexidine acetate, dodecyl dimethyl benzyl ammonium bromide, benzethonium chloride, didecyl dimethyl ammonium bromide, benzalkonium chloride and benzalkonium bromide.

Further, the aldehyde bactericide is any one or more of glutaraldehyde, formaldehyde, succinaldehyde, glyoxal and o-phthalaldehyde.

Further, the synergist is any one or more of hydrogen peroxide, phenoxyethanol, hydroxyethylidene diphosphonic acid, isopropanol, xylitol, dimethyl sulfoxide, perchloric acid and organophosphorus.

Further, the thickener is one or more of carbomer 940, carbomer 980NF, carbomer 2020, carbomer ULTREZ20, carbomer ULTREZ21, Xanthomonas polysaccharide, konjac gum and PEG.

Further, the skin-care moisturizer is any one or more of butanediol, ethylhexyl glycerin, sorbitol, PEG, polyglycerol-10, amino acid, trehalose, chitosan oligosaccharide and aloe extract.

Further, the neutralizing agent is any one or more of triethanolamine, sodium hydroxide, sodium bicarbonate and DL-aminopropanol.

Further, the PH adjusting agent is any one or more of a sodium phosphate buffer solution, a potassium phosphate buffer solution, a citric acid-sodium hydrogen phosphate buffer solution, a citric acid-sodium citrate buffer solution, a sodium hydrogen carbonate solution, sodium hydroxide, sodium carbonate and sodium hydrogen carbonate.

Further, the solubilizer is any one or more of ethanol, propylene glycol and glycerol; the zwitterionic surfactant is any one or more of lecithin and betaine.

In order to solve the technical problems, the invention also provides a preparation method of the special alcohol-free no-wash virus inactivation disinfectant for children, which comprises the following specific steps:

s1: adding purified water accounting for 80% of the total preparation amount into a reaction kettle for shearing and stirring treatment, wherein the shearing rotation speed is 300-;

s2: uniformly dispersing the cationic bactericide in the pure water treated in the step S1, and uniformly stirring to obtain a solution A;

s3: adding the aldehyde bactericide and the synergist into the solubilizer according to the formula amount for dissolving, and uniformly stirring to obtain a solution B;

s4: uniformly dispersing the zwitterionic surfactant with the formula ratio on the surface of purified water, standing for swelling, and uniformly stirring to obtain a solution C;

s5: uniformly dispersing the thickening agent with the formula ratio on the surface of purified water, standing for swelling, and uniformly stirring to obtain a solution D;

s6: adding the solution A in the step S2, the solution B in the step S3, the solution C in the step S4 and the solution D in the step S5 into the purified water in the step S1, stirring while adding, and fully and uniformly mixing;

s7: and (4) sequentially adding the skin-care humectant, the pH regulator and the essence into the solution obtained in the step (S6), uniformly stirring, adding a neutralizing agent to prepare the liquid into a liquid state, continuously stirring for 30 minutes, standing overnight, filtering, filling and sealing to obtain a finished product.

Compared with the prior art, the invention has the beneficial effects that: the invention has stable performance, high efficiency and rapidness in disinfection, no washing, fresh and cool hand feeling after use without stickiness, simple preparation process, no need of heating, cost saving and suitability for industrial mass production; the hand cleaning and disinfecting liquid can meet the requirements of cleaning and disinfecting hands of children at any time and any place, can quickly kill common pathogenic bacteria and viruses on the skin surface, and has broad-spectrum and powerful effects of sterilizing and killing viruses; the composition has good endurance, and the effect can last for 4-5 hours; the probability of germ infection can be reduced by 80 percent, and potential health risks are avoided; meanwhile, the product has good skin care and moisturizing effects, and can overcome skin dryness, chapping, allergy and other adverse side effects caused by long-term use.

Detailed Description

In order to make the objects, technical solutions and advantages of the present invention more apparent, the present invention is further described in detail below with reference to examples, and the exemplary embodiments and descriptions thereof are only used for explaining the present invention and are not used as limitations of the present invention.

Example (b):

the embodiment provides an alcohol-free no-wash virus inactivation disinfectant special for children, which comprises the following components in percentage by mass: 0.05-2% of cationic bactericide, 0.0005-0.02% of cationic surfactant or zwitterionic surfactant, 0.01-1% of aldehyde bactericide, 0.05-2% of synergist, 0.1-5% of skin-care humectant, 0.2-2% of neutralizer, 1-10% of solubilizer, 0.05-3% of thickener, pH value of pH regulator adjusting system of 7.2-8.2, and the balance of pure water.

The cationic bactericide used in the embodiment is any one or more of chlorhexidine gluconate, chlorhexidine acetate, dodecyl dimethyl benzyl ammonium bromide, benzethonium chloride, didecyl dimethyl ammonium bromide, benzalkonium chloride and benzalkonium bromide; the aldehyde bactericide is any one or more of glutaraldehyde, formaldehyde, succinaldehyde, glyoxal and o-phthalaldehyde; the synergist is one or more of hydrogen peroxide, phenoxyethanol, hydroxyethylidene diphosphonic acid, isopropanol, xylitol, dimethyl sulfoxide, perchloric acid and organophosphorus; the thickener is one or more of carbomer 940, carbomer 980NF, carbomer 2020, carbomer ULTREZ20, carbomer ULTREZ21, Xanthomonas polysaccharide, konjac gum and PEG; the skin caring humectant is one or more of butanediol, ethylhexyl glycerol, sorbitol, PEG, polyglycerol-10, amino acids, trehalose, chitosan oligosaccharide and aloe extract; the neutralizing agent is one or more of triethanolamine, sodium hydroxide, sodium bicarbonate and DL-aminopropanol; the pH regulator is one or more selected from sodium phosphate buffer, potassium phosphate buffer, citrate buffer (citric acid-sodium hydrogen phosphate buffer, citric acid-sodium citrate buffer), sodium bicarbonate solution, sodium hydroxide, sodium carbonate and sodium bicarbonate; the solubilizer is one or more of ethanol, propylene glycol and glycerol; the used zwitterionic surfactant is one or more of lecithin and betaine.

In the embodiment, a compound system is formed by a compound technology of cations and aldehyde bactericides. After the cation and the aldehyde bactericide are compounded, the cation and the aldehyde bactericide form a stable compound in a proper proportion, and can be well compounded with the synergist, so that the generation of flocculent precipitates is avoided, and the system is clear and transparent and has no precipitates. The hand feel is fresh and cool without stickiness after use, and the problem of activity reduction of the cationic bactericide in the presence of a nonionic detergent is solved. When the bactericidal composition is used together with aldehydes and a synergist, the bactericidal effect is enhanced. In the embodiment, the cationic bactericide and the aldehyde bactericide are used for synergistic sterilization, so that common pathogenic bacteria and viruses can be quickly killed, and the long-acting sterilization effect can be ensured by compounding the cationic bactericide and the aldehyde bactericide. Not only has reliable killing effect on common pathogenic bacteria, but also has strong killing effect on hand-foot-mouth virus, influenza virus, poliovirus, herpes virus, rotavirus and the like. The embodiment also adds effective skin care ingredients, moisturizes and moistens the skin, has a multifunctional humectant, plays a role in antisepsis and synergism, is tasteless, can form a bacteriostatic environment in the formula, and plays a role in antisepsis and bacteriostasis on the whole formula. Meanwhile, the hand skin dryness caused by long-term use of the hand sanitizer by children can be prevented, hands are effectively cared, and meanwhile, the weakly acidic formula is close to the pH value of the skin, so that the hands are protected. The comprehensive performance of the disinfectant is superior to that of the similar products in the market, the use of ethanol is avoided, the injury to children and the potential risks in production, storage, transportation and use are avoided, and the gap of domestic special hand-washing disinfectants for children is filled.

The product of this embodiment is capable of killing comprising: escherichia coli, Candida albicans, hepatitis pathogenic bacteria, salmonella, Staphylococcus aureus, Salmonella typhimurium, Pseudomonas aeruginosa-free, Salmonella enterica, enterococcus faecalis, Diplococcus pneumoniae, Pseudomonas aeruginosa, Chromobacterium mirabilis, hand-foot-and-mouth virus, influenza virus, coronavirus, poliovirus, herpesvirus, rotavirus, hepatitis A virus, hepatitis B virus, hepatitis C virus, AIDS virus, feline calicivirus.

The synergist used in the embodiment can enhance the activity of the bactericide component, and the synergist especially has a particularly obvious enhancement effect on viruses, has the advantages of broad spectrum, high efficiency and low corrosivity, and also has the self characteristics of small irritation, low use concentration, good stability and the like; the dodecyl dimethyl benzyl ammonium bromide (cationic surfactant) has the functions of cleaning, sterilizing, disinfecting and algae removal, and is widely applied to the aspects of sterilization, disinfection, corrosion prevention, emulsification, scale removal, solubilization and the like, and the bactericidal power is 300-400 times that of phenol. Dodecyl dimethyl benzyl ammonium bromide has similar performance to benzalkonium chloride, but has stronger bactericidal performance than 1227 (dodecyl dimethyl benzyl ammonium chloride) because bromine atoms replace chlorine atoms in molecules, has the property of a typical cationic surfactant, is stable in property, light-resistant, heat-resistant and non-volatile, and can be stored for a long time. The dodecyl dimethyl benzyl ammonium bromide has lower toxicity than Jieer, is lower than dodecyl dimethyl benzyl ammonium chloride and is far lower than chlorophenol components, has no stimulation to tissues and has no in-vivo accumulated toxicity; the didecyl dimethyl ammonium bromide (cationic surfactant) belongs to a double-chain quaternary ammonium salt compound, has stable chemical property and small irritation, is used as a disinfectant and a sterilization mildew preventive in the aspects of medicine, health, civil use and the like, and has the effects of sterilization and disinfection. The didecyl dimethyl ammonium bromide can completely kill various pathogenic microorganisms such as viruses, bacteria, moulds, fungi and the like, the sterilizing power is not influenced by organic matter pollution, light, heat, hard water, pH value, temperature, humidity and the like, the pesticide effect lasts for a long time, the efficacy can last for 10 to 14 days after the use, and the didecyl dimethyl ammonium bromide disinfectant is a recognized special disinfectant for drinking water disinfection, water quality improvement and livestock disease control.

The o-phthalaldehyde in the components of the product is an aldehyde medical intermediate, is a latest external efficient safe antibacterial disinfectant, is often used as an endoscope surgical instrument for disinfection and sterilization, has a sterilization mechanism of protein denaturation or alkylation, and has the sterilization characteristic of being effective on bacteria, spores, fungi and viruses. The disinfectant can be used as disinfectant, and the acute toxicity of the o-phthalaldehyde is the same as that of the salt. Can kill bacterial spores and inactivate hand-foot-and-mouth viruses, influenza viruses, coronavirus, poliovirus, herpes viruses, rotavirus and the like. It has little irritation to eyes and nasal passages, little noticeable odor, no need for activation before use, and excellent material compatibility. The o-phthalaldehyde serving as a novel efficient disinfectant not only has the advantages of broad spectrum, high efficiency and low corrosivity, but also has the characteristics of small irritation, low use concentration, good stability and the like compared with glutaraldehyde, and has been developed into a novel disinfectant and passes the American FDA certification.

In the embodiment, dodecyl dimethyl amine oxide and didecyl dimethyl ammonium bromide are selected for compounding, so that the microbial community drug resistance generated by simply using quaternary ammonium salt is avoided. Therefore, on the basis, the core structure is formed by combining the o-phthalaldehyde and the synergist, so that the negative-charged bacteria are adsorbed and gathered on the cell wall to generate a chamber resistance effect by the action of electrostatic force, hydrogen bond force, hydrophobic combination between surfactant molecules and protein molecules and the like in the bactericide, the bacteria are inhibited in growth and die, the escherichia coli, staphylococcus aureus and candida albicans can be killed within 30 seconds, and the killing rate is 99.999%. The brand new compound components of the embodiment can effectively reduce the surface tension of water, obviously improve the viscosity of an aqueous solution, and have the effects of inhibiting scale and adjusting the pH value; most importantly, the molecular structure of the quaternary ammonium salt can be changed from symmetry to extremely asymmetric structural characteristics, and the positive charge density of the quaternary ammonium salt can be catalyzed to be rapidly increased, so that the surfactant can be more easily adsorbed on the surface of bacteria, the permeability of bacterial cell walls is changed and the bacterial cell walls are broken, and the effect of efficiently killing the bacteria is achieved. The super sun-proof moisturizing factor (trehalose and chitosan oligosaccharide) is added, so that the hand-protecting hand cream has the functions of controlling the oxidative stress level of hands of children, preventing skin injury and protecting hands, and can moisten and care the skin of hands. The embodiment adopts a unique alcohol-free formula compounding technology, improves the application safety of children, avoids fire safety hidden dangers in production, storage and transportation, and reduces the damage of the disinfectant to the skin of the children. The special alcohol-free wash-free virus inactivation disinfectant long-term stabilizing system for children is built, the stability is excellent, the effective period can reach more than 2 years, great convenience is provided for the processes of storage, transportation, sale and use, and the operation cost is greatly reduced.

The product of the embodiment can be directly sprayed on hands as a hand disinfectant, can safely, effectively and conveniently remove pathogenic bacteria and viruses on the hands at any time and any place without water and soap, can form a colorless and transparent invisible film on the hands, and keeps the long-time inhibition and sterilization effects. The product of the embodiment can effectively control the propagation of typhoid fever, influenza, dysentery, pinkeye, gonorrhea and various viruses, and the special alcohol-free and wash-free virus inactivation disinfectant for children is not only used for disinfecting hands of children, but also suitable for being used in restaurants, hotels, hospitals, markets, banks, schools, kindergartens, families, offices and travels to carry out waterless hand wash-free disinfection.

When the alcohol-free no-wash virus inactivation disinfectant special for children is prepared, purified water added into the main active component is stirred in advance, the process is particularly critical, and the purified water is subjected to independent shearing stirring treatment at room temperature, so that the purified water is fully pre-activated. Under preferred conditions: the shearing speed is 300-; the surface tension of water molecules is reduced, the specific surface area of water is increased, the solubility of purified water to solute molecules is increased, and the intermolecular interaction is accelerated. Meanwhile, the fusion and coating effects among the components can be fully exerted, so that the prepared disinfectant has the disinfecting effect different from that of other quaternary ammonium salt mild disinfectants. The method comprises the following specific steps:

s1: adding purified water accounting for 80% of the total preparation amount into a reaction kettle for shearing and stirring treatment, wherein the shearing rotation speed is 300-;

s2: uniformly dispersing the cationic bactericide in the pure water treated in the step S1, and uniformly stirring to obtain a solution A;

s3: adding the aldehyde bactericide and the synergist into the solubilizer according to the formula amount for dissolving, and uniformly stirring to obtain a solution B;

s4: uniformly dispersing the zwitterionic surfactant with the formula ratio on the surface of purified water, standing for swelling, and uniformly stirring to obtain a solution C;

s5: uniformly dispersing the thickening agent with the formula ratio on the surface of purified water, standing for swelling, and uniformly stirring to obtain a solution D;

s6: adding the solution A in the step S2, the solution B in the step S3, the solution C in the step S4 and the solution D in the step S5 into the purified water in the step S1, stirring while adding, and fully and uniformly mixing;

s7: and (4) sequentially adding the skin-care humectant, the pH regulator and the essence into the solution obtained in the step (S6), uniformly stirring, adding a neutralizing agent to prepare the liquid into a liquid state, continuously stirring for 30 minutes, standing overnight, filtering, filling and sealing to obtain a finished product.

In this example, a test of acute oral toxicity of the alcohol-free wash-free virus-inactivated disinfectant special for children was performed on KM mice, and the mice were contaminated with the disinfectant of this example in a gavage manner, and the experimental results are shown in the following table:

test results of acute oral toxicity of KM mice

After the mice are infected with the virus, no obvious abnormal symptom and sign are seen, other abnormal manifestations and death do not occur after continuous observation for 14 days, the animals are sacrificed after the observation period to carry out autopsy, and no abnormality occurs in each main organ through visual observation.

This example also carried out a complete skin irritation test using a Japanese big ear white rabbit, the exposure method: removing hair from skin on two sides of spinal column of Japanese big ear white rabbit 24h before test, and the area is about 3cm multiplied by 3 cm; the following day, 0.5mL of a stock solution of the test sample (disinfectant of this example) was applied to the skin on the left side of 2.5cm × 2.5cm, and the right side was used as a blank control, and after 4 hours of application, the skin was washed with warm water to remove the residual test sample; applying once a day, the method is the same as the above, and continuously applying for 14 d; in order to facilitate smearing of the test sample and observation of the results, the hairs were shaved again if necessary.

The results are shown in the table below, and it can be seen that the local reaction of the skin is observed 24h after each administration, the skin on the infected side and the skin on the control side of 3 Japanese white rabbits in 14d are not abnormal, and the visible stimulation intensity is nonirritating.

Multiple complete skin irritation response scoring results for Japanese big ear white rabbits

In this example, the mouse bone marrow pleochromocyte micronucleus test was performed, and the contamination method was as follows: the animal is infected by oral gavage for 30h, i.e. the interval between two times of infection is 24h, the infection volume is 0.2mL/10g body weight, and the material is taken 6h after the second time of infection. The result shows that the tested sample induces the mouse bone marrow pleochromocyte micronucleus test, compared with the negative control group, the animal bone marrow pleochromocyte micronucleus rate has no significant difference (p is more than 0.05), and compared with the negative control group, the cyclophosphamide positive control group has very significant difference (p is less than 0.01). The PCE/NCE ratio of the bone marrow of animals in each dose group is more than 0.1, which indicates that the tested sample has no obvious inhibition effect on the bone marrow, and the PCE/NCE ratio of each dose group of the sample has no significant difference compared with the negative control group (p is more than 0.05). During the administration period, no obvious abnormal performance was observed in the animals of each dose group. In summary, the results show that the hand-free disinfectant for children of the present example has no micronucleus-causing effect on mouse myeloeosinophils.

As shown in the following table, the microbial contamination control indexes of the hand-free disinfectant for children in the embodiment are all in accordance with the regulations.

Microbial contamination control index of hand-washing-free disinfectant for children

The above is an embodiment of the present invention. The embodiments and specific parameters in the embodiments are only for the purpose of clearly illustrating the process of verifying the invention and are not intended to limit the scope of the invention, which is defined by the claims, and all the equivalent structural changes made by applying the content of the specification of the invention should be covered by the scope of the invention.

Claims (10)

1. The alcohol-free no-wash virus inactivation disinfectant special for children is characterized by comprising the following components in percentage by mass: 0.05-2% of cationic bactericide, 0.0005-0.02% of cationic surfactant or zwitterionic surfactant, 0.01-1% of aldehyde bactericide, 0.05-2% of synergist, 0.1-5% of skin-care humectant, 0.2-2% of neutralizer, 1-10% of solubilizer, 0.05-3% of thickener, pH value of pH regulator adjusting system of 7.2-8.2, and the balance of pure water.

2. The alcohol-free, wash-free virus-inactivating disinfectant special for children according to claim 1, wherein the cationic bactericide is any one or more of chlorhexidine gluconate, chlorhexidine acetate, dodecyl dimethyl benzyl ammonium bromide, benzethonium chloride, didecyl dimethyl ammonium bromide, benzalkonium chloride and benzalkonium bromide.

3. The alcohol-free no-wash virus inactivation disinfectant special for children according to claim 1, wherein the aldehyde bactericide is any one or more of glutaraldehyde, formaldehyde, succinaldehyde, glyoxal and o-phthalaldehyde.

4. The alcohol-free, wash-free and virus-inactivating disinfectant special for children according to claim 1, wherein the synergist is any one or more of hydrogen peroxide, phenoxyethanol, hydroxyethylidene diphosphonic acid, isopropanol, xylitol, dimethyl sulfoxide, perchloric acid and organophosphorus.

5. The children specific alcohol-free leave-on virus inactivation disinfectant as claimed in claim 1, wherein the thickening agent is any one or more of carbomer 940, carbomer 980NF, carbomer 2020, carbomer ULTREZ20, carbomer ULTREZ21, xanthopolysaccharide, konjac glucomannan and PEG.

6. The alcohol-free no-wash virus inactivation disinfectant special for children according to claim 1, wherein the skin care moisturizer is any one or more of butylene glycol, ethylhexyl glycerin, sorbitol, PEG, polyglycerol-10, amino acid, trehalose, chitosan oligosaccharide and aloe extract.

7. The alcohol-free no-wash virus inactivation disinfectant special for children as claimed in claim 1, wherein the neutralizing agent is any one or more of triethanolamine, sodium hydroxide, sodium bicarbonate and DL-aminopropanol.

8. The alcohol-free no-wash virus inactivation disinfectant special for children according to claim 1, wherein the pH regulator is any one or more of a sodium phosphate buffer solution, a potassium phosphate buffer solution, a citric acid-sodium hydrogen phosphate buffer solution, a citric acid-sodium citrate buffer solution, a sodium bicarbonate solution, sodium hydroxide, sodium carbonate and sodium bicarbonate.

9. The alcohol-free no-wash virus inactivation disinfectant special for children according to claim 1, wherein the solubilizer is any one or more of ethanol, propylene glycol and glycerol; the zwitterionic surfactant is any one or more of lecithin and betaine.

10. The preparation method of the alcohol-free no-wash virus inactivation disinfectant special for children as claimed in any one of claims 1 to 9, characterized by comprising the following steps:

s1: adding purified water accounting for 80% of the total preparation amount into a reaction kettle for shearing and stirring treatment, wherein the shearing rotation speed is 300-;

s2: uniformly dispersing the cationic bactericide in the pure water treated in the step S1, and uniformly stirring to obtain a solution A;

s3: adding the aldehyde bactericide and the synergist into the solubilizer according to the formula amount for dissolving, and uniformly stirring to obtain a solution B;

s4: uniformly dispersing the zwitterionic surfactant with the formula ratio on the surface of purified water, standing for swelling, and uniformly stirring to obtain a solution C;

s5: uniformly dispersing the thickening agent with the formula ratio on the surface of purified water, standing for swelling, and uniformly stirring to obtain a solution D;

s6: adding the solution A in the step S2, the solution B in the step S3, the solution C in the step S4 and the solution D in the step S5 into the purified water in the step S1, stirring while adding, and fully and uniformly mixing;

s7: and (4) sequentially adding the skin-care humectant, the pH regulator and the essence into the solution obtained in the step (S6), uniformly stirring, adding a neutralizing agent to prepare the liquid into a liquid state, continuously stirring for 30 minutes, standing overnight, filtering, filling and sealing to obtain a finished product.