


技术领域technical field
本发明涉及种植牙技术领域,更具体地说,涉及一种可促进骨结合的种植体周围炎治疗装置。The invention relates to the technical field of dental implants, in particular to a treatment device for peri-implantitis that can promote osseointegration.
背景技术Background technique
重建医疗技术中可利用种植牙取代失去患者拔出或掉落的牙齿,种植牙主要包括代替患者原有牙冠的修复牙冠、通过骨结合与牙槽骨结合的植体以及连接修复牙冠和植体的基台。Dental implants can be used in reconstructive medical technology to replace the extracted or fallen teeth of lost patients. Dental implants mainly include restoration crowns that replace the patient's original crowns, implants that integrate with the alveolar bone through osseointegration, and connection restoration crowns. and implant abutments.
随着种植牙的植入年限增加,越来越多的患者发生种植体周围炎。目前,植体周围炎的常规非手术治疗方法为,拆卸植体上方的基台并翻开患者的牙龈,用刮刀等器具对种植体表面的生物膜进行清除,用注射器等器具进行药液清洗,操作复杂且生物膜去除效率较低。With the increase of implant years, more and more patients develop peri-implantitis. At present, the conventional non-surgical treatment method for peri-implantitis is to remove the abutment above the implant and open the patient's gums, remove the biofilm on the surface of the implant with a scraper and other instruments, and clean it with a syringe and other instruments. , complex operation and low biofilm removal efficiency.
现有的牙周清洗仪器并非专门为种植体设计,难以去除植体表面的生物膜,无法进行深层清洁和杀菌,而种植体周围炎治疗装置或是无固定装置,需要医生手持操作,操作不便、无法维持医疗效果的稳定性,或是冲洗后的废液无法回收,导致废液沿患者的口腔和脸颊流出,可能导致污染和患者的不适。Existing periodontal cleaning instruments are not specially designed for implants, and it is difficult to remove the biofilm on the surface of the implants, and cannot perform deep cleaning and sterilization. The treatment device for peri-implantitis or no fixed device needs to be operated by the doctor, which is inconvenient to operate , The stability of the medical effect cannot be maintained, or the waste liquid after flushing cannot be recovered, causing the waste liquid to flow out along the patient's mouth and cheeks, which may cause pollution and discomfort to the patient.
综上所述,如何提供一种便于操作、稳定安全的种植体周围炎治疗装置,是目前本领域技术人员亟待解决的问题。To sum up, how to provide an easy-to-operate, stable and safe treatment device for peri-implantitis is an urgent problem to be solved by those skilled in the art.
发明内容Contents of the invention
有鉴于此,本发明的目的是提供一种可促进骨结合的种植体周围炎装置,利用超声波对种植体周围腔隙进行振荡清洗,并对植体进行机械微刺激、促进植体与牙槽骨的骨结合。In view of this, the object of the present invention is to provide a device for peri-implantitis that can promote osseointegration, which uses ultrasonic waves to vibrate and clean the cavity around the implant, and performs mechanical micro-stimulation on the implant to promote the healing of the implant and the alveolar. Osseointegration of bones.
为了实现上述目的,本发明提供如下技术方案:In order to achieve the above object, the present invention provides the following technical solutions:
一种可促进骨结合的种植体周围炎治疗装置,包括壳体,所述壳体内设有药液供应管、超声波发生装置、换能传输装置、用于回收废液的负压回收装置、控制装置和电源,所述电源、所述超声波发生装置、所述换能传输装置以及所述负压回收装置均与所述控制装置连接;A treatment device for peri-implantitis that can promote osseointegration, comprising a casing, the casing is provided with a liquid medicine supply tube, an ultrasonic generating device, an energy conversion transmission device, a negative pressure recovery device for recovering waste liquid, a control device and power supply, the power supply, the ultrasonic generating device, the energy conversion transmission device and the negative pressure recovery device are all connected to the control device;
所述壳体的端部设有用于与植体螺纹连接的治疗尖,所述治疗尖包括与所述药液供应管连通的药液管和与所述负压回流装置连通的回流管,所述药液管与所述换能传输装置连接,所述回流管套设于所述药液管外;The end of the housing is provided with a treatment tip for threaded connection with the implant, and the treatment tip includes a drug solution tube communicated with the drug solution supply tube and a return tube communicated with the negative pressure return device. The liquid medicine pipe is connected to the transducing transmission device, and the return pipe is sleeved outside the liquid medicine pipe;
所述药液管设有若干个用于插入所述植体与牙龈间缝隙的工作尖,所述工作尖设有用于排出药液的药液孔;The medicinal solution tube is provided with several working tips for inserting into the gap between the implant and the gum, and the working tips are provided with medicinal solution holes for discharging the medicinal solution;
所述回流管的外周设有若干个废液回流孔。The outer periphery of the return pipe is provided with several waste liquid return holes.
优选的,所述工作尖为硬度小于牙本质的软性工作尖。Preferably, the working tip is a soft working tip whose hardness is less than that of dentin.
优选的,所述工作尖在所述药液管的圆周方向上均匀分布。Preferably, the working tips are evenly distributed in the circumferential direction of the liquid medicine tube.
优选的,所述废液回流孔在所述回流管的圆周方向上均匀分布。Preferably, the waste liquid return holes are evenly distributed in the circumferential direction of the return pipe.
优选的,所述壳体内还设有用于增加药液压力的增压装置,所述增压装置与所述药液供应管连接并连通,所述增压装置与所述控制装置连接。Preferably, a booster device for increasing the pressure of the liquid medicine is also provided in the housing, the booster device is connected and communicated with the liquid medicine supply pipe, and the booster device is connected with the control device.
优选的,所述负压回收装置包括负压装置和用于与废液箱连通的废液管,所述负压装置与所述废液管连接并连通,所述负压装置与所述控制装置连接。Preferably, the negative pressure recovery device includes a negative pressure device and a waste liquid pipe for communicating with the waste liquid tank, the negative pressure device is connected and communicated with the waste liquid pipe, the negative pressure device is connected with the control device connection.
优选的,所述换能传输装置包括用于将超声波转化为机械振动的换能装置和用于传递机械振动的传振机构,所述传振机构内设有所述药液供应管。Preferably, the transducer transmission device includes a transducer device for converting ultrasonic waves into mechanical vibrations and a vibration transmission mechanism for transmitting mechanical vibrations, and the medicinal liquid supply tube is arranged in the vibration transmission mechanism.
本发明提供的可促进骨结合的种植体周围炎治疗装置工作时,首先拆卸患者的基台,将治疗尖拧紧固定于植体;控制装置控制超声波发生装置、换能传输装置和负压回收装置打开,抗菌药液依次流经药液供应管、药液管并通过工作尖的药液孔进入植体与牙龈之间的缝隙,在超声波的振动下药液对植体周围的腔隙进行振荡清洗,清洗后的废液在负压回流装置制造的负压环境的作用下通过废液回流孔经进入回流管,而后通过负压回流装置被回收到废液箱,同时超声波的振动经由治疗尖传递至植体上,可以机械微刺激的方式促进植体与牙槽骨的骨结合。When the treatment device for peri-implantitis that can promote osseointegration provided by the present invention works, the patient’s abutment is first disassembled, and the treatment tip is tightened and fixed on the implant; the control device controls the ultrasonic generating device, the energy conversion transmission device and the negative pressure recovery device Open, the antibacterial liquid flows through the liquid supply tube, the liquid tube in turn, and enters the gap between the implant and the gum through the liquid hole of the working tip, and the liquid vibrates the cavity around the implant under the ultrasonic vibration Cleaning, the cleaned waste liquid enters the return pipe through the waste liquid return hole under the action of the negative pressure environment created by the negative pressure return device, and then is recycled to the waste liquid tank through the negative pressure return device, while the ultrasonic vibration passes through the treatment tip Delivered to the implant, it can promote the osseointegration of the implant and the alveolar bone in a mechanical micro-stimulation manner.
本发明提供的可促进骨结合的种植体周围炎治疗装置,可与植体螺纹连接,有效地固定了治疗尖的位置,无需医生手动调节,便于操作,有利于维持医疗效果的稳定性;废液回收装置可利用负压回收清洗后产生的废液,避免了废液可能导致的污染,提升了患者的舒适感;超声波一方面可实现药液在植体周围腔隙的振荡清洗,清洗效果好,另一方面可促进植体与牙槽骨的骨结合,有利于增强种植牙的稳定性。The peri-implantitis treatment device that can promote osseointegration provided by the present invention can be threadedly connected with the implant, effectively fixes the position of the treatment tip, does not require manual adjustment by the doctor, is easy to operate, and is conducive to maintaining the stability of the medical effect; waste The liquid recovery device can use negative pressure to recover the waste liquid produced after cleaning, avoiding the possible pollution caused by the waste liquid, and improving the comfort of the patient; on the one hand, the ultrasonic wave can realize the oscillation cleaning of the liquid medicine in the cavity around the implant, and the cleaning effect Well, on the other hand, it can promote the osseointegration of the implant and the alveolar bone, which is beneficial to enhance the stability of the implant.
附图说明Description of drawings
为了更清楚地说明本发明实施例或现有技术中的技术方案,下面将对实施例或现有技术描述中所需要使用的附图作简单地介绍,显而易见地,下面描述中的附图仅仅是本发明的实施例,对于本领域普通技术人员来讲,在不付出创造性劳动的前提下,还可以根据提供的附图获得其他的附图。In order to more clearly illustrate the technical solutions in the embodiments of the present invention or the prior art, the following will briefly introduce the drawings that need to be used in the description of the embodiments or the prior art. Obviously, the accompanying drawings in the following description are only It is an embodiment of the present invention, and those skilled in the art can also obtain other drawings according to the provided drawings without creative work.
图1为本发明所提供的可促进骨结合的种植体周围炎治疗装置的具体实施例的结构示意图;FIG. 1 is a schematic structural view of a specific embodiment of the peri-implantitis treatment device that can promote osseointegration provided by the present invention;
图2为治疗尖的结构示意图;Fig. 2 is a structural schematic diagram of a treatment tip;
图3为治疗尖的剖视示意图。Fig. 3 is a schematic cross-sectional view of the treatment tip.
图1-图3中:In Figure 1-Figure 3:
1为壳体、2为药液供应管、3为电源、4为控制装置、5为负压装置、6为增压装置、7为超声波发生装置、8为换能装置、9为传振机构、10为治疗尖、101为药液管、102为回流管、103为工作尖、104为废液回流孔、 105为连接螺纹、11为废液管。1 is the casing, 2 is the liquid medicine supply pipe, 3 is the power supply, 4 is the control device, 5 is the negative pressure device, 6 is the booster device, 7 is the ultrasonic generator, 8 is the energy conversion device, and 9 is the vibration transmission mechanism , 10 is a treatment point, 101 is a liquid medicine pipe, 102 is a return pipe, 103 is a working point, 104 is a waste liquid return hole, 105 is a connecting thread, and 11 is a waste liquid pipe.
具体实施方式Detailed ways
下面将结合本发明实施例中的附图,对本发明实施例中的技术方案进行清楚、完整地描述,显然,所描述的实施例仅仅是本发明一部分实施例,而不是全部的实施例。基于本发明中的实施例,本领域普通技术人员在没有做出创造性劳动前提下所获得的所有其他实施例,都属于本发明保护的范围。The following will clearly and completely describe the technical solutions in the embodiments of the present invention with reference to the accompanying drawings in the embodiments of the present invention. Obviously, the described embodiments are only some, not all, embodiments of the present invention. Based on the embodiments of the present invention, all other embodiments obtained by persons of ordinary skill in the art without making creative efforts belong to the protection scope of the present invention.
本发明的核心是提供一种可促进骨结合的种植体周围炎装置,利用超声波对种植体周围腔隙进行振荡清洗,并对植体进行机械微刺激、促进植体与牙槽骨的骨结合。The core of the present invention is to provide a peri-implantitis device that can promote osseointegration, which uses ultrasonic waves to vibrate and clean the cavity around the implant, and mechanically stimulates the implant to promote osseointegration between the implant and the alveolar bone .
请参考图1-图3,图1为本发明所提供的可促进骨结合的种植体周围炎治疗装置的具体实施例的结构示意图;图2为治疗尖的结构示意图;图3 为治疗尖的剖视示意图。Please refer to Fig. 1-Fig. 3, Fig. 1 is the structural schematic diagram of the specific embodiment of the peri-implantitis treatment device that can promote osseointegration provided by the present invention; Fig. 2 is the structural schematic diagram of the treatment tip; Fig. 3 is the treatment tip Cutaway diagram.
本发明提供的可促进骨结合的种植体周围炎治疗装置,包括壳体1,壳体1内设有药液供应管2、超声波发生装置7、换能传输装置、用于回收废液的负压回收装置、控制装置4和电源3,电源3、超声波发生装置7、换能传输装置以及负压回收装置均与控制装置4连接;壳体1的端部设有用于与植体螺纹连接的治疗尖10,治疗尖10包括与药液供应管2连通的药液管101和与负压回流装置连通的回流管102,药液管101与换能传输装置连接,回流管102套设于药液管101外;药液管101设有若干个用于插入植体与牙龈间缝隙的工作尖103,工作尖103设有用于排出药液的药液孔;回流管102的外周设有若干个废液回流孔104。The device for treating peri-implantitis that can promote osseointegration provided by the present invention includes a housing 1, which is provided with a liquid
其中,超声波发生装置7和换能传输装置用于制造超声波并将超声波转换为机械振动传递至植体处;药液供应管2外接药液管道,负压回收装置外接废液箱,以便对清洗后的废液进行回收,减少废液污染;控制装置4 用于控制调节超声波发生装置7的超声波频率、强度和工作时间,并控制负压回收装置的开启和关闭。Among them, the ultrasonic generating device 7 and the transducing transmission device are used to produce ultrasonic waves and convert the ultrasonic waves into mechanical vibrations and transmit them to the implant; the medicinal
超声波发生装置7和换能传输装置二者可以独立设置,也可以集成为微型超声波马达等装置一体设置,以减小超声波发生装置7和换能传输装置所需的安装空间,减小口腔治疗装置的整体体积。参考现有的牙周清理器材标准,控制装置4优选地设置超声波发生装置7的超声波波长8um、频率为100Hz,运行时间由医生根据患者的炎症范围等设定。Both the ultrasonic generating device 7 and the transducing transmission device can be arranged independently, or can be integrated into a device such as a miniature ultrasonic motor, so as to reduce the required installation space of the ultrasonic generating device 7 and the transducing transmitting device, and reduce the oral cavity treatment device. of the overall volume. With reference to the existing periodontal cleaning equipment standards, the control device 4 preferably sets the ultrasonic wavelength of the ultrasonic generator 7 to 8um and the frequency to 100Hz, and the operating time is set by the doctor according to the range of inflammation of the patient.
优选的,换能传输装置包括用于将超声波转为机械振动的换能装置8 和用于传递机械振动的传振机构9,传振机构9内设有药液供应管2。Preferably, the energy transducing transmission device includes an energy transducing device 8 for converting ultrasonic waves into mechanical vibrations and a
控制装置4、超声波发生装置7、换能装置8、传振机构9以及药液供应管2的结构、形状、尺寸、材质、连接方式等根据实际治疗需要参考现有技术确定,在此不再赘述。The structure, shape, size, material, connection method, etc. of the control device 4, the ultrasonic generator 7, the transducer device 8, the
治疗尖10是进行种植体周围炎治疗的主要结构,一方面通过药液对植体周围腔隙进行振荡清洗,另一方面利用超声波的机械振动促进植体与牙槽骨的骨结合。The treatment tip 10 is the main structure for treating peri-implantitis. On the one hand, it vibrates and cleans the cavity around the implant through liquid medicine, and on the other hand, it uses ultrasonic mechanical vibration to promote the osseointegration of the implant and the alveolar bone.
由于治疗尖10不仅向植体周围腔隙输送药液,还从腔隙内回收清洗后产生的废液,为了区分药液和废液,治疗尖10为内外筒结构,内筒为输送药液的药液管101,外筒为回收废液的回流管102,药液管101和回流管102 完全隔开,以免废液与药液掺混。Since the treatment tip 10 not only delivers the liquid medicine to the cavity around the implant, but also recovers the waste liquid produced after cleaning from the cavity. The
请参考图3,治疗尖10设有连接螺纹105,连接螺纹105用于与植体螺纹连接,连接螺纹105的尺寸可根据与植体配适的基台的参数确定。Please refer to FIG. 3 , the treatment tip 10 is provided with a connecting
为了避免损伤植体,优选的,治疗尖10采用硬度小于牙本质的软性材料制作,有效地避免了振动损伤植体或导致患者不适。In order to avoid damage to the implant, preferably, the treatment tip 10 is made of a soft material with a hardness lower than that of the dentin, which effectively prevents vibration from damaging the implant or causing discomfort to the patient.
治疗尖10多采用聚酰胺材料等常见口腔医疗器械材料一体成型制作;治疗尖10的尺寸受到植体直径、患者牙位、患者炎症范围等因素的影响,在此不再赘述。The treatment tip 10 is mostly made of polyamide materials and other common oral medical device materials; the size of the treatment tip 10 is affected by factors such as the diameter of the implant, the position of the patient's teeth, and the extent of the patient's inflammation, so it will not be repeated here.
请参考图2和图3,工作尖103连接于药液管101靠近植体的端面,工作尖103为前端开孔的中空结构,工作尖103用于向植体与牙龈间的腔隙输送药液并进行振荡清洗。为了方便工作尖103插入植体与牙龈之间,工作尖103一般设置为圆柱体或锥体。Please refer to Figure 2 and Figure 3, the working
优选的,工作尖103为硬度小于牙本质的软性工作尖,高频振动时动作轻柔,避免损伤植体和牙龈,可有效减轻振动造成的不适感。Preferably, the working
优选的,工作尖103在药液管101的圆周方向上均匀分布,以便更好地对植体各方位进行生物膜去除和药液杀菌清洁。Preferably, the
废液回流孔104用于负压回收植体周围腔隙内的废液,废液回流孔104 的形状和数量不限,废液回流孔104的尺寸根据工作尖103处药液的流速、工作尖103上药液孔的尺寸等确定。The waste
优选的,废液回流孔104在回流管102的圆周方向上均匀分布。请参考图3,回流管102的外周部均匀设有三个废液回流孔104。Preferably, the waste liquid return holes 104 are evenly distributed in the circumferential direction of the
治疗时,首先拆卸患者的基台,将治疗尖10拧紧固定于植体;控制装置4控制超声波发生装置7、换能传输装置和负压回收装置打开,抗菌药液依次流经药液供应管2、药液管101并通过工作尖103的药液孔进入植体与牙龈之间的缝隙,在超声波的振动下药液对植体周围的腔隙进行振荡清洗,清洗后的废液在负压回流装置制造的负压环境的作用下通过废液回流孔 104经进入回流管102,而后通过负压回流装置被回收到废液箱,同时超声波的振动经由治疗尖10传递至植体上,可以机械微刺激的方式促进植体与牙槽骨的骨结合。During the treatment, the patient’s abutment is dismantled first, and the treatment tip 10 is tightened and fixed on the implant; the control device 4 controls the ultrasonic generator 7, the energy conversion transmission device and the negative pressure recovery device to open, and the antibacterial liquid flows through the liquid supply pipe in
在本实施例中,治疗尖10可与植体螺纹连接,有效地固定了治疗尖10 的位置,无需医生手持调节,便于操作,有利于维持医疗效果的稳定性;废液回收装置可利用负压回收清洗后产生的废液,避免了废液可能导致的污染,提升了患者的舒适感;超声波一方面可实现药液在植体周围腔隙的振荡清洗,清洗效果好,另一方面可促进植体与牙槽骨的骨结合,有利于增强种植牙的稳定性。In this embodiment, the treatment tip 10 can be threadedly connected with the implant, which effectively fixes the position of the treatment tip 10, and does not need to be adjusted by the doctor, which is easy to operate and helps to maintain the stability of the medical effect; the waste liquid recovery device can use negative The waste liquid produced after cleaning is recovered by pressure, which avoids the possible pollution caused by the waste liquid and improves the comfort of the patient; Promote the osseointegration of the implant and the alveolar bone, which is beneficial to enhance the stability of the implant.
优选的,治疗尖10与壳体1可拆卸连接,以便根据不同患者的需要更换不同尺寸的治疗尖10,扩大种植体周围炎治疗装置的适用范围。Preferably, the treatment tip 10 is detachably connected to the housing 1, so that the treatment tip 10 of different sizes can be replaced according to the needs of different patients, so as to expand the application range of the peri-implantitis treatment device.
治疗尖10与壳体1可以为螺纹连接,也可以为法兰连接等其他常见的可拆卸连接方式。The treatment tip 10 and the housing 1 can be connected by thread, or by other common detachable connection methods such as flange connection.
在上述实施例的基础上,为了更好地对植体周围腔隙进行振荡清洗,壳体1内还设有用于增加药液压力的增压装置6,增压装置6与药液供应管 2连接并连通,增压装置6与控制装置4连接。On the basis of the above-mentioned embodiments, in order to better vibrate and clean the cavity around the implant, the housing 1 is also provided with a booster 6 for increasing the pressure of the liquid medicine. The booster 6 is connected to the liquid
增压装置6可以设置为微型增压泵等,控制装置4与增压装置6连接,可对增压装置6的压力和开关进行调节。The booster device 6 can be set as a micro booster pump, etc., and the control device 4 is connected to the booster device 6 to adjust the pressure and switch of the booster device 6 .
在本实施例中,增压装置6可提高药液流动的速度,药液对植体和牙龈处生物膜的冲击增强,对生物膜的清除能力增强,可更好地起到深层清洁和杀菌的作用。In this embodiment, the pressurization device 6 can increase the flow rate of the liquid medicine, and the impact of the liquid medicine on the implant and the biofilm on the gums is enhanced, and the ability to remove the biofilm is enhanced, which can better perform deep cleaning and sterilization role.
在上述实施例的基础上,负压回收装置包括负压装置5和用于与废液箱连通的废液管11,负压装置5和废液管11连接并连通,负压装置5与控制装置4连接。On the basis of the foregoing embodiments, the negative pressure recovery device includes a negative pressure device 5 and a
负压装置5用于制造负压环境,促使废液被压入废液管11中;废液管11远离植体的一端与废液箱连接,可对废液进行有效回收。The negative pressure device 5 is used to create a negative pressure environment to push the waste liquid into the
负压装置5和废液管11的结构、形状、尺寸和材质等请根据实际治疗中的需要参考现有技术确定,在此不再赘述。The structure, shape, size and material of the negative pressure device 5 and the
本说明书中各个实施例采用递进的方式描述,每个实施例重点说明的都是与其他实施例的不同之处,各个实施例之间相同相似部分互相参见即可。Each embodiment in this specification is described in a progressive manner, each embodiment focuses on the difference from other embodiments, and the same and similar parts of each embodiment can be referred to each other.
以上对本发明所提供的可促进骨结合的种植体周围炎治疗装置进行了详细介绍。本文中应用了具体个例对本发明的原理及实施方式进行了阐述,以上实施例的说明只是用于帮助理解本发明的方法及其核心思想。应当指出,对于本技术领域的普通技术人员来说,在不脱离本发明原理的前提下,还可以对本发明进行若干改进和修饰,这些改进和修饰也落入本发明权利要求的保护范围内。The device for treating peri-implantitis that can promote osseointegration provided by the present invention has been described in detail above. In this paper, specific examples are used to illustrate the principle and implementation of the present invention, and the descriptions of the above embodiments are only used to help understand the method and core idea of the present invention. It should be pointed out that for those skilled in the art, without departing from the principle of the present invention, some improvements and modifications can be made to the present invention, and these improvements and modifications also fall within the protection scope of the claims of the present invention.
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202110700393.7ACN113425432B (en) | 2021-06-23 | 2021-06-23 | Peri-implant inflammation treatment device capable of promoting bone union |
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202110700393.7ACN113425432B (en) | 2021-06-23 | 2021-06-23 | Peri-implant inflammation treatment device capable of promoting bone union |
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| CN113425432A CN113425432A (en) | 2021-09-24 |
| CN113425432Btrue CN113425432B (en) | 2023-05-26 |
| Application Number | Title | Priority Date | Filing Date |
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| CN202110700393.7AActiveCN113425432B (en) | 2021-06-23 | 2021-06-23 | Peri-implant inflammation treatment device capable of promoting bone union |
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| CB03 | Change of inventor or designer information | Inventor after:Wang Shuhua Inventor after:Lin Yicong Inventor after:Zhang Ming Inventor after:Xu Jiehan Inventor before:Wang Shuhua Inventor before:Lin Yicong Inventor before:Zhang Ming | |
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| TR01 | Transfer of patent right | Effective date of registration:20230821 Address after:310013 No. 548 binwen Road, Binjiang District, Hangzhou City, Zhejiang Province Patentee after:ZHEJIANG CHINESE MEDICAL University Patentee after:Stomatological Hospital Affiliated to Zhejiang University of traditional Chinese Medicine Co.,Ltd. Address before:310013 No. 548 binwen Road, Binjiang District, Hangzhou City, Zhejiang Province Patentee before:ZHEJIANG CHINESE MEDICAL University |