CN113295875A - Sample analysis system - Google Patents

Abstract

Translated fromChinese

本申请涉及一种样本分析系统，包括：至少两个特定蛋白分析仪、样本移送设备和控制设备，样本移送设备包括：具有传输通道的传输机构和至少两个具有检测通道的进给机构，每个特定蛋白分析仪均对应一个进给机构，且每个特定蛋白分析仪的检测区域分别与其对应的进给机构的检测通道相对应。控制设备用于控制样本移送设备将放置有需要进行特定蛋白检测的样本容器的待测样本架移送至特定蛋白分析仪之一。该样本分析系统在至少两个特定蛋白分析仪中选择一个特定蛋白分析仪，对当前需要进行特定蛋白检测的待测样本架进行检测，可以对待测样本架进行合理分配，能够降低对特定蛋白测量模块的速度要求，满足较大样本量的测量需求，提高特定蛋白测量效率。

The present application relates to a sample analysis system, comprising: at least two specific protein analyzers, a sample transfer device and a control device, the sample transfer device includes: a transfer mechanism with a transfer channel and at least two feed mechanisms with a detection channel, each Each specific protein analyzer corresponds to one feeding mechanism, and the detection area of each specific protein analyzer corresponds to the detection channel of its corresponding feeding mechanism respectively. The control device is used for controlling the sample transfer device to transfer the sample rack to be tested on which the sample container to be tested for the specific protein is placed to one of the specific protein analyzers. The sample analysis system selects a specific protein analyzer from at least two specific protein analyzers, and detects the sample racks to be tested that currently need specific protein detection. The speed requirements of the module meet the measurement requirements of larger sample volumes and improve the measurement efficiency of specific proteins.

Description

Sample analysis system

Technical Field

The present application relates to the field of medical diagnostic equipment, and more particularly, to a sample analysis system.

Background

CRP (C-reactive protein) is an acute phase reaction protein, is normally present in a small amount in human body fluid, is increased to different degrees in infectious diseases, and has important clinical application value. Particularly, with the rapid development of the point-of-care rapid detection technology in recent years, the application of CRP in clinical infectious diseases is more extensive, and the CRP is the focus of clinical research again.

Blood routine is one of three routine examinations, and is also one of the commonly used auxiliary examinations for doctors to diagnose the disease. Doctors can assist in judging the physical condition by observing the number change and the morphological distribution of blood cells. The CRP detection result and the conventional blood detection result have higher correlation, and the CRP detection is often used for identifying bacterial infection and viral infection by doctors in combination with the conventional blood detection due to the characteristics of simple operation, high detection speed, small required sample amount and the like.

The existing sample analysis system integrates the measurement functions of blood routine and CRP, but generally comprises a set of detection equipment and a plurality of blood routine measurement pools and a plurality of CRP measurement pools, the number of the blood routine measurement pools and the CRP measurement pools is small due to instrument cost and volume limitation, and the measurement speed of the blood routine and the CRP is greatly limited due to only one set of detection equipment. In clinic, basically all samples need blood routine test, and CRP only accounts for a certain proportion as an inflammation test item, so that a large-flux and high-efficiency blood routine measuring device is clinically needed, and a high-speed CRP measuring instrument is attached to be used together with the blood routine test and the CRP joint test.

Disclosure of Invention

In order to solve the above technical problem, the present application provides a sample analysis system.

A first aspect of the present application provides a sample analysis system comprising: at least two specific protein analyzers for specific protein detection, a sample transfer device, and a control device, wherein the sample transfer device comprises: the sample rack conveying device comprises a conveying mechanism with a conveying channel and at least two feeding mechanisms with a detection channel, wherein the conveying mechanism is used for transferring sample racks with sample containers in the conveying channel, each feeding mechanism is arranged at intervals along the conveying direction of the conveying channel, and the feeding mechanisms can transfer the sample racks from the conveying channel to the detection channel and transfer the sample racks from the detection channel to the conveying channel; each specific protein analyzer corresponds to one feeding mechanism, and the detection area of each specific protein analyzer corresponds to the detection channel of the corresponding feeding mechanism; the at least two specific protein analyzers are configured to detect at least one identical specific protein; the control device is electrically connected to each of the specific protein analyzer and the sample transfer device and configured to: and when the measurement mode information indicates that a sample container needing to be subjected to specific protein detection is placed on the sample rack to be detected, controlling the sample transfer equipment to transfer the sample rack to be detected to a detection area of one of the at least two specific protein analyzers according to the operation state information.

Optionally, the operational status information comprises detection load information for each specific protein analyzer; the control device is used for controlling the sample transfer device to transfer the sample rack to be detected to a detection area of a specific protein analyzer with a smaller detection load in the at least two specific protein analyzers according to the detection load information of each specific protein analyzer.

Optionally, the control device is further configured to: determining the waiting time of the sample rack to be detected according to the detection load information of each specific protein analyzer, and controlling the sample transfer equipment to transfer the sample rack to be detected to a detection area of a specific protein analyzer with a smaller detection load in the at least two specific protein analyzers after the waiting time.

Optionally, the sample analysis system further comprises an unloading platform and other analyzers different from the at least two specific protein analyzers, the control device further for: and when the waiting time is longer than the preset time, controlling the sample transfer equipment to transfer the sample rack to be tested to the unloading platform or other analyzers.

Optionally, the sample analyzer system further comprises at least one blood cell analyzer for routine blood testing, each blood cell analyzer corresponds to one of the feeding mechanisms, and a testing area of each blood cell analyzer corresponds to a testing channel of its corresponding feeding mechanism.

Optionally, the at least one hematology analyzer is positioned in front of the at least two specific protein analyzers in the transport direction along the transport channel.

Optionally, the at least one blood cell analyzer includes a scanning device for acquiring measurement mode information of the sample container on the sample rack to be tested; the control device is used for controlling the sample transfer device to transfer the sample rack to be detected to one of the blood cell analyzers for primary blood routine detection and acquiring measurement mode information of a sample container on the sample rack to be detected, and when the measurement mode information indicates that the sample container needing specific protein detection is placed on the sample rack to be detected, controlling the sample transfer device to transfer the sample rack to be detected, which is subjected to primary blood routine detection, to a detection area of one of the at least two specific protein analyzers according to the operation state information.

Optionally, each of the at least two specific protein analyzers includes a scanning device for confirming measurement mode information of the sample container on the sample rack to be tested.

Optionally, the sample analysis system further comprises a loading platform located before the at least one hematology analyzer in the transport direction along the transport channel and used for placing a sample rack to be tested, and a platform loading mechanism for transferring the sample rack on the loading platform to the transport channel; and the loading platform is provided with a scanning device for identifying the sample rack placed on the loading platform and the sample identifier, and establishing and storing the corresponding relation between the sample identifier and the sample rack position.

Optionally, the control device is electrically connected to each of the hematology analyzers and is configured to acquire blood routine test data for each of the hematology analyzers; the control equipment is also used for determining a sample container with blood routine detection data meeting preset rechecking conditions as a rechecking sample container, and determining one of the at least one hematology analyzer as a rechecking hematology analyzer for rechecking the rechecking sample container.

Optionally, the control device is configured to, when the sample rack to be tested includes a retest sample container and a sample container that needs to be subjected to specific protein detection, control the sample transfer device to transfer the sample rack to be tested that has undergone a first blood routine detection to the retest blood cell analyzer for a blood routine retest, and then control the sample transfer device to transfer the retest sample rack to be subjected to a blood routine retest to a detection area of one of the at least two specific protein analyzers for a specific protein detection after the retest sample container on the sample rack to be tested undergoes a blood routine retest.

Optionally, the control device is configured to, when the sample rack to be tested includes a retest sample container and a sample container that needs to be subjected to specific protein detection, control the sample transfer device to move the sample rack to be tested, which has undergone a first blood routine test, to a detection area of one of the at least two specific protein analyzers to perform specific protein detection, and then transfer the sample rack to be tested, which has undergone specific protein detection, to the retest hematology analyzer to perform a blood routine retest.

Optionally, the sample analyzer system comprises at least two hematology analyzers for routine testing of blood; at least one of the at least two hematology analyzers is positioned in front of the at least two specific protein analyzers in the transport direction along the transport channel.

Optionally, the at least two hematology analyzers comprise: at least one high blood matching sphere analyzer and at least one low blood matching sphere analyzer, wherein the detection items of the high blood matching sphere analyzer are different from the detection items of the low blood matching sphere analyzer; the low match sphere analyzer is positioned in front of the high match sphere analyzer in a direction of transport along the transport channel.

Optionally, the control device is further configured to: electrically connected to each of said hematology analyzers and configured for obtaining blood routine test data for each of said hematology analyzers; determining a sample container of which the blood routine detection data meet preset rechecking conditions as a rechecking sample container and determining a rechecking mode of the rechecking sample container, wherein the rechecking mode comprises a same-item rechecking mode and an additional-item rechecking mode; when the sample rack to be detected comprises a retest sample container with a retest mode being the same item retest mode, controlling the sample transfer equipment to transfer the sample rack to be detected to a hematology analyzer for performing primary routine blood detection on the retest sample container for retest; and when the sample rack to be detected comprises a retest sample container with a retest mode being an item retest mode, controlling the sample transfer equipment to transfer the sample rack to be detected to the high blood matching ball analyzer for retest.

Optionally, at least one of the at least two specific protein analyzers is located between the low and high hematocrit analyzers in a transport direction along the transport channel; the control device is used for controlling the sample transfer equipment to convey the sample rack to be detected to the specific protein analyzer positioned between the low blood distribution globe analyzer and the high blood distribution globe analyzer when the sample rack to be detected comprises a retest sample container with a retest mode being an item retest mode and a sample container needing specific protein detection, and controlling the sample transfer equipment to transfer the sample rack to be detected to the high blood distribution globe analyzer for retest after specific protein detection is finished.

Optionally, the at least two specific protein analyzers are selected from a group consisting of a C-reactive protein analyzer, a serum amyloid a analyzer, a procalcitonin analyzer, and other specific protein analyzers, or include two or more of them.

A second aspect of the present application provides a sample analysis system comprising: one specific protein analyzer for specific protein detection, a sample transfer device, a control device and at least two blood cell analyzers for routine blood detection, wherein the sample transfer device comprises: the sample rack conveying device comprises a conveying mechanism with a conveying channel and at least three feeding mechanisms with detection channels, wherein the conveying mechanism is used for transferring sample racks with sample containers in the conveying channel, each feeding mechanism is arranged at intervals along the conveying direction of the conveying channel, and the feeding mechanisms can transfer the sample racks from the conveying channel to the detection channels and transfer the sample racks from the detection channels to the conveying channel; the specific protein analyzer and each blood cell analyzer correspond to one feeding mechanism, and the detection areas of the specific protein analyzer and each blood cell analyzer correspond to the detection channels of the feeding mechanisms corresponding to the specific protein analyzer and each blood cell analyzer respectively; the specific protein analyzer is located between the at least two hematology analyzers in a transport direction along the transport channel; the control device is electrically connected with the sample transfer device and configured to: and acquiring measurement mode information of a sample container on a sample rack to be detected, and controlling the sample transfer equipment to transfer the sample rack to be detected loaded with the sample to the specific protein analyzer and/or any one of the blood cell analyzers according to the measurement mode information to perform corresponding detection.

Optionally, the control device is electrically connected to each of the hematology analyzers and is configured to acquire blood routine test data for each of the hematology analyzers;

the control equipment is also used for determining a sample container with blood routine detection data meeting preset rechecking conditions as a rechecking sample container, and determining one of the at least two blood cell analyzers as a rechecking blood cell analyzer for rechecking the rechecking sample container.

Optionally, the control device is configured to, when the sample rack to be tested includes a retest sample container and a sample container that needs to be subjected to specific protein detection, control the sample transfer device to transfer the sample rack to be tested to the retest hematology analyzer for routine retest, and then control the sample transfer device to transfer the retest sample rack to be tested to the detection area of the specific protein analyzer for specific protein detection after the retest sample container on the sample rack to be tested is subjected to routine retest.

Optionally, the control device is configured to, when the sample rack to be tested includes a retest sample container and a sample container that needs to be subjected to specific protein detection, control the sample transfer device to move the sample rack to be tested to a detection area of the specific protein analyzer for specific protein detection, and then transfer the sample rack to be tested that is subjected to specific protein detection to the retest hematology analyzer for routine retest of blood.

Optionally, the at least two hematology analyzers comprise: at least one high blood matching sphere analyzer and at least one low blood matching sphere analyzer, wherein the detection items of the high blood matching sphere analyzer are different from the detection items of the low blood matching sphere analyzer; the low match sphere analyzer is positioned in front of the high match sphere analyzer in a direction of transport along the transport channel.

Optionally, the control device is further configured to: electrically connected to each of said hematology analyzers and configured for obtaining blood routine test data for each of said hematology analyzers; determining a sample container of which the blood routine detection data meet preset rechecking conditions as a rechecking sample container and determining a rechecking mode of the rechecking sample container, wherein the rechecking mode comprises a same-item rechecking mode and an additional-item rechecking mode; when the sample rack to be detected comprises a retest sample container with a retest mode being the same item retest mode, controlling the sample transfer equipment to transfer the sample rack to be detected to a hematology analyzer for performing primary routine blood detection on the retest sample container for retest; and when the sample rack to be detected comprises a retest sample container with a retest mode being an item retest mode, controlling the sample transfer equipment to transfer the sample rack to be detected to the high blood matching ball analyzer for retest.

Optionally, the specific protein analyzer is located after the low match ball analyzer and before the high match ball analyzer in the transport direction along the transport channel; the control device is used for controlling the sample transfer equipment to convey the sample rack to be detected to the specific protein analyzer when the sample rack to be detected comprises a reinspection sample container with an item reinspection mode and a sample container needing specific protein detection, and controlling the sample transfer equipment to transfer the sample rack to be detected to the high-match hematology analyzer for reinspection after the specific protein detection is finished.

Compared with the prior art, the technical scheme provided by the embodiment of the application has the following advantages: this sample analysis system can select a specific protein analysis appearance in two at least specific protein analysis appearance, detects the sample frame that awaits measuring that needs carry out specific protein detection at present to when having a plurality of sample frames that await measuring that need carry out specific protein detection, can carry out rational distribution to the sample frame that awaits measuring, can reduce the speed requirement to specific protein measuring module, satisfy the measurement demand of great sample size, improve specific protein measurement of efficiency.

Drawings

The accompanying drawings, which are incorporated in and constitute a part of this specification, illustrate embodiments consistent with the invention and together with the description, serve to explain the principles of the invention.

In order to more clearly illustrate the embodiments of the present invention or the technical solutions in the prior art, the drawings used in the description of the embodiments or the prior art will be briefly described below, and it is obvious for those skilled in the art that other drawings can be obtained according to the drawings without inventive exercise.

Fig. 1 to 7 are schematic structural diagrams of sample analysis systems according to various embodiments of the present disclosure;

fig. 8 is a schematic structural diagram of a control device according to an embodiment of the present application.

Detailed Description

In order to make the objects, technical solutions and advantages of the embodiments of the present application clearer, the technical solutions in the embodiments of the present application will be clearly and completely described below with reference to the drawings in the embodiments of the present application, and it is obvious that the described embodiments are some embodiments of the present application, but not all embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present application.

Fig. 1 is a schematic diagram of a sample analysis system according to an embodiment of the present disclosure.

As shown in fig. 1, the sample analysis system includes: at least two specific protein analyzers (including a firstspecific protein analyzer 10 and a secondspecific protein analyzer 20 in the figure), a sample transfer device, and acontrol device 30 for specific protein detection.

In an embodiment of the present application, the at least two specific protein analyzers are configured to detect at least one same specific protein, and the at least two specific protein analyzers are selected from a group consisting of a C-reactive protein (CRP) analyzer, a Serum Amyloid A (SAA) analyzer, a Procalcitonin (PCT) analyzer, and other specific protein analyzers, or a combination comprising two or more of the above analyzers. For example, the at least two specific protein analyzers are both analyzers capable of detecting CRP only, or are all integrators capable of detecting CRP and/or SAA, or one of the specific protein analyzers is an analyzer capable of detecting CRP only and the other specific protein analyzer is an integrator capable of detecting CRP and/or SAA.

The sample transfer device is used for transferring a sample rack with a sample container, and in the embodiment of the application, the sample transfer device comprises: atransport mechanism 41 and at least twofeed mechanisms 42 with detection channels.

A transport channel is formed in thetransport mechanism 41, and the sample rack can be moved in the transport channel by thetransport mechanism 41. Thefeeding mechanisms 42 are arranged at the side of the conveying channel, thefeeding mechanisms 42 are arranged at intervals along the conveying direction X of the conveying channel, and an interval is arranged betweenadjacent feeding mechanisms 42, and thefeeding mechanisms 42 are used for transferring the sample rack from the conveying channel to the detecting channel and transferring the sample rack from the detecting channel to the conveying channel.

In a specific application, thetransmission mechanism 41 may be any one or more combinations of a chain mechanism, a crawler mechanism, a belt mechanism, a roller mechanism, and a track mechanism, and if multiple combinations are adopted, thetransmission mechanism 41 may be matched according to a plurality of different types of mechanisms arranged along the transmission channel.

In the embodiment of the present application, thetransport mechanism 41 is only required to complete the transfer of the sample rack, and the shape of the transport channel is not limited, for example: the transmission channel can be a linear type, a broken line with a certain angle, an arc line with a certain radian, or even an irregular shape.

In the embodiment of the present application, the transmission channel may be a planar channel, for example: the upper surface of a belt of the belt type mechanism is directly used as a transmission channel; in addition, considering that the sample rack may fall or twist in position when being transferred, the transmission channel may be a semi-enclosed channel, such as: the baffle plates are arranged on two sides of the belt type mechanism, and the top of each baffle plate is not closed, so that a semi-enclosed transmission channel is formed in an area enclosed by the baffle plates, and the sample rack is restrained by the baffle plates and cannot fall off or be twisted in position. In addition, considering that the sample rack may be placed in a mess after the sample container is manually taken when the sample rack is moved, the transmission channel may be configured as a totally enclosed channel, for example: the baffle plates are arranged on the two sides and the top of the belt type mechanism, so that when the sample rack is transferred in the transmission channel, an operator cannot take the sample rack, and manual intervention can be avoided.

In the embodiment of the present application, the transport channel is used as a main channel, each detection channel is used as a sub-channel, in operation, thetransport mechanism 41 may move the sample rack to the position of eachfeeding mechanism 42 on the transport channel, and then thefeeding mechanism 42 may move the sample rack from the transport channel to the corresponding detection channel, and thefeeding mechanism 42 may also move the sample rack from the detection channel back to the transport channel.

Onefeeding mechanism 42 may be provided for each specific protein analyzer, and the detection channel of eachfeeding mechanism 42 corresponds to the position of the detection area of the corresponding specific protein analyzer, such as: the detection channel coincides with the position of the detection area. Therefore, when the sample frame moves in the detection channel, the sample frame can move to the detection area of the specific protein analyzer, and then the sample in the sample container on the sample frame can be collected by the specific protein analyzer to perform detection and analysis on the sample.

In the embodiment of the present application, thefeeding mechanism 42 may also adopt any one or more combinations of a chain type mechanism, a crawler type mechanism, a belt type mechanism, a roller type mechanism, and a rail type mechanism, and if multiple combinations are adopted, thefeeding mechanism 42 may be provided with multiple sections of mechanisms of different types to cooperate. For a detailed description of thefeeding mechanism 42, reference is made to the description of thetransport mechanism 41. And will not be described in detail herein.

In the present embodiment, the first specific protein analyzer 10 (e.g., a C-reactive protein detectable CRP analyzer) and the second specific protein analyzer 20 (e.g., a C-reactive protein detectable CRP analyzer) each correspond to onefeeding mechanism 42, and the detection area of the firstspecific protein analyzer 10 and the secondspecific protein analyzer 20 corresponds to the detection channel of thefeeding mechanism 42 corresponding thereto, so that the sample in the sample container on the sample rack can be subjected to specific protein analysis in the firstspecific protein analyzer 10 or the secondspecific protein analyzer 20. In other embodiments, the same feeding mechanism may be provided for a plurality of specific protein analyzers, and the detection regions of the plurality of specific protein analyzers are arranged along the detection channel of the same feeding mechanism.

The firstspecific protein analyzer 10 and the secondspecific protein analyzer 20 are used to detect specific proteins of samples transferred from the sample transfer device to the sample containers on the sample racks in the corresponding detection channels.

As shown in fig. 1, in the present embodiment, a firstspecific protein analyzer 10 is located in front of a secondspecific protein analyzer 20 in a transport direction X along a transport path. In some embodiments, the positions of the firstspecific protein analyzer 10 and the secondspecific protein analyzer 20 are not limited, and the front and rear order may be freely set.

In the embodiment of the present application, "front" and "rear" are both relative concepts, where "front" refers to a position passing first along the transport direction X, and "rear" refers to a position passing later along the transport direction X, and then the firstspecific protein analyzer 10 is located in front of the secondspecific protein analyzer 20, that is, the sample rack on the transport channel passes through the firstspecific protein analyzer 10 first, and then passes through the secondspecific protein analyzer 20. Taking the direction shown in fig. 1 as an example, if the transmission direction X is from right to left, then "front" refers to a position relatively to the right in the figure, and "rear" refers to a position relatively to the left in the figure, therefore, "front" and "rear" in the embodiment of the present application describe the relative positional relationship between the firstspecific protein analyzer 10 and the secondspecific protein analyzer 20, and are not intended to be simply understood in the literal sense, which should not be construed as limiting the present application.

Thecontrol device 30 is electrically connected to the firstspecific protein analyzer 10, the secondspecific protein analyzer 20, and the sample transfer device, and thecontrol device 30 may be a desktop computer, a laptop computer, a single chip computer, a PDA, or other devices with computing capability. In the embodiment of the present application, thecontrol device 30 is used to obtain the operation state information of each specific protein analyzer and the measurement mode information of the sample container on the sample rack to be tested. The running state information refers to information of running of the specific protein analyzer when the specific protein analyzer detects the specific protein of the sample, and the running state information at least comprises detection load information of the specific protein analyzer, namely the number of the sample containers to be detected which are distributed to the specific protein analyzer for detection at present. In other embodiments of the present application, the operating status information may also include machine status information, such as fault information, enablement information, and the like. The measurement mode information refers to item information to be detected of samples in each sample container on the sample rack to be detected, the detection items corresponding to different modes are different, the measurement mode information can be a preset mode, and the preset mode can be directly received in a cable/wireless mode.

When the measurement mode information indicates that a sample container requiring specific protein detection is placed on the current sample rack to be detected, thecontrol device 30 controls the sample transfer device to transfer the sample rack to be detected to the detection area of one of the at least two specific protein analyzers according to the operation state information, so that the specific protein detection can be performed on the sample container requiring specific protein detection on the sample rack to be detected in the appropriate specific protein analyzer.

In the embodiment of the application, the speed requirement on the specific protein measuring module can be reduced by arranging a plurality of specific protein analyzers capable of detecting the same specific protein, the measuring requirement of a larger sample size is met, and the specific protein measuring efficiency is improved.

As shown in fig. 1, in some embodiments of the present application, thefeeding mechanism 42 of the sample analysis system further comprises:actuator 421, load buffer 422, andload mechanism 423.

Thetransmission mechanism 421 may be any one or a combination of a chain mechanism, a crawler mechanism, a belt mechanism, a roller mechanism, and a track mechanism, and if a plurality of combinations are adopted, thetransmission mechanism 421 may be provided with a plurality of sections of mechanisms of different types. In the embodiment of the present application, thetransmission 421 has a detection passage formed therein. And the position of the detection channel corresponds to the position of the detection area of the analyzer corresponding to thefeeding mechanism 42, so that the detection of the sample container transferred in the detection channel can be smoothly completed.

As shown in fig. 1, the loading buffer 422 is located between the detection channel and the transmission channel, and the configuration of the loading buffer 422 mainly considers that if the number of sample racks transferred to the analyzer by the transmission channel is large, a certain time is consumed for the analyzer to complete each sample rack, and if all the sample racks on the transmission channel are transferred to the analyzer, normal analysis and detection are affected, the configuration of the loading buffer 422 can enable the sample racks transferred on the transmission channel to be buffered in the region first, and then the sample racks buffered in the region are sequentially transferred to the detection channel according to the detection speed of the analyzer.

As shown in fig. 1, theloading mechanism 423 is located at the bottom of the loading buffer 422, and is used for transferring the sample rack passing through the transport channel to the loading buffer 422, and transferring the sample rack loaded in the loading buffer 422 to the detection channel.

As shown in fig. 1, thefeeding mechanism 42 further includes an unloadingbuffer area 424 and an unloading mechanism 425, wherein the unloadingbuffer area 424 is located between the detection channel and the transportation channel, and the unloadingbuffer area 424 and the loading buffer area 422 are arranged at intervals along the transportation direction of the detection channel, for example, the loading buffer area 422 and the unloading buffer area 425 are respectively located at two ends of the detection channel. The unloading mechanism 425 is located in the unloading buffer area, and is used for transferring the sample rack passing through the detection channel to the unloadingbuffer area 424, and transferring the sample rack in the unloadingbuffer area 424 to the transmission channel.

In one embodiment of the present application, the operating state information includes test load information for each specific protein analyzer, the test load information referring to the number of samples currently assigned to each specific protein analyzer to be tested.

In order to further improve the detection efficiency of the specific protein, when thecontrol device 30 controls the sample transfer device to transfer the sample rack to be detected, the control method may be as follows:

thecontrol device 30 determines the specific protein analyzer with a smaller load according to the detection load information of each specific protein analyzer, and then thecontrol device 30 controls the sample transfer device to transfer the current sample rack to be detected to the detection area of the specific protein analyzer with a smaller detection load (i.e. being more idle) among the at least two specific protein analyzers.

By adopting the transfer mode, the specific protein analyzer with smaller detection load is preferentially selected, so that the detection waiting time of the specific protein on the assembly line can be shortened, and the detection efficiency of the specific protein can be improved.

In an embodiment of the present application, the operating status information may also include machine status information, such as fault information. For example, when one of the specific protein analyzers fails or needs to replace consumables and/or reagents, the specific protein analyzer may be automatically separated from the sample analyzer system, and thecontrol device 30 does not schedule the sample rack to be tested to the specific protein analyzer that is otherwise operating normally.

In an embodiment of the present application, when the detection load information of each specific protein analyzer indicates that the corresponding specific protein analyzer is in a busy state (the busy state indicates that the number of samples waiting for performing specific protein in the specific protein analyzer is greater than the processing capacity of the specific protein analyzer, and the specific protein analyzer needs to be idle after continuously working for a period of time), on one hand, if the sample rack to be detected is still transferred to the specific protein analyzer in the busy state, the waiting time is longer due to the busy state of the specific protein analyzer; on the other hand, limited space is available for the feeding mechanism corresponding to the specific protein analyzer, and once the number of the sample racks contained in the feeding mechanism corresponding to the specific protein analyzer in the busy state is saturated, no extra free position in the feeding mechanism corresponding to the specific protein analyzer in the busy state can contain a new sample rack. For this purpose, thecontrol device 30 may determine a waiting time period T1 of the rack of samples to be tested before being tested according to the test load information of each specific protein analyzer, and then start timing, and when the timing time period T0 is T1, control the sample transfer device to transfer the samples to be tested to the test area of a specific protein analyzer with a smaller test load among the at least two specific protein analyzers.

In an embodiment of the present application, the sample analysis system may further include: an off-loading platform and other analyzers different from the at least two specific protein analyzers. The unloading platform may be located at the rearmost position in the transfer direction of the transfer device, i.e., at the end position in the X direction. The other analyzer may be a hemocytometer, a saccharification machine, a slide dyeing machine, etc., and the position between the other analyzer and the at least two specific protein analyzers may be freely set. For example, as shown in fig. 2, theblood cell analyzer 60 is located in front of the firstspecific protein analyzer 10 and the secondspecific protein analyzer 20 in the transport direction along the transport path, and the push-piece stainer 50 is located behind the secondspecific protein analyzer 20. As shown in fig. 2, the sample analysis system further comprises anunloading platform 80 for placing the sample rack. Theunloading platform 80 is arranged at one end of the transfer passage, in fig. 2 at the end of the transfer direction X of the transfer passage. The sample racks on the transport path may all be transported to theunloading platform 80 for storage.

In addition, referring to fig. 2, the sample analysis system further includes aplatform unloading mechanism 81 for transferring the sample rack in the transport channel to theunloading platform 80, and optionally transferring the sample on theunloading platform 80 into the transport channel.

Considering that the transport path on thetransport mechanism 41 is shared, if the waiting time T1 of the sample rack to be tested is too long, it may affect the testing speed of the sample containers on the sample rack to be tested that need to be transported to other analyzers for testing other items (such as saccharification or slide), or cause too many sample racks to be tested waiting to be transported, which may affect the efficiency of the sample analyzer system, or even cause traffic jam. In order to efficiently multiplex the transmission channels on thetransmission mechanism 41, in the embodiment of the present application, after the waiting time period T1 is calculated, it may be determined whether the waiting time period T1 is greater than a preset time period Tx (the preset time period Tx may be a time period set by an operator), when T1 is greater than Tx, the specific protein analyzer of the sample analysis system is still in a busy state, at this time, thecontrol device 30 may control the sample transfer device to transfer the sample rack to be tested to the unloading platform or another analyzer, that is, skip the specific protein detection on the sample rack to be tested, and unload the sample rack to the unloading platform or transport the sample rack to another analyzer for measurement.

The current sample rack to be tested is transferred to the unloading platform or other analyzers, so that the transfer channel of the transfer equipment is not occupied, the transfer convenience is provided for other sample racks to be tested, and the transfer efficiency of the transfer channel is improved. For example, when the sample rack to be tested is waiting on the unloading platform, the detection load information of the specific protein analyzer may be continuously monitored, and when the detection condition of the specific protein is met, the sample rack to be tested is transferred from the unloading platform back to the transmission channel, and then the sample rack to be tested is transferred to the corresponding specific protein analyzer by thetransmission mechanism 41 for detection. For example, if the sample in the current sample rack to be tested has other testing items besides the specific protein testing item, thecontrol device 30 may control the sample transfer device to transfer the current sample rack to be tested to other analyzers on the transmission channel, where the transfer to other analyzers may facilitate the testing of other testing items on the sample in the sample container on the current sample rack to be tested first, and the testing of other testing items is performed first by using the waiting time of the current sample rack to be tested for the specific protein testing item, so as to improve the overall testing efficiency of the sample with multiple testing items.

In an embodiment of the present application, the sample analysis system may further include at least one blood cell analyzer, preferably at least two blood cell analyzers, for routine blood detection, each corresponding to one of the feedingmechanisms 42, and a detection area of each blood cell analyzer corresponds to a detection channel of itscorresponding feeding mechanism 42. In some embodiments, at least one hematology analyzer is positioned in front of at least two specific protein analyzers in the transport direction along the transport channel. As shown in fig. 4, theblood cell analyzer 60 is included in the drawing, and theblood cell analyzer 60 is located in front of the firstspecific protein analyzer 10 in the transport direction X.

In the embodiment of the invention, the specific protein measurement speed can be matched with the conventional blood measurement speed by arranging the plurality of specific protein analyzers and the at least one blood cell analyzer, so that the risk of traffic jam caused by the fact that the conventional blood measurement speed is higher than the detection speed of the specific protein in the sample analyzer system can be reduced.

If the sample analysis system only has at least two specific protein analyzers, that is, the sample analysis system only performs specific protein detection, all sample containers placed on a sample rack to be detected of the sample analysis system need to perform specific protein detection, so that the specific protein analyzers only need to perform specific protein detection on each sample container transferred to the detection area of the specific protein analyzer. If the sample analysis system further comprises at least one blood cell analyzer, the sample analysis system will no longer be used solely for specific protein detection, but can also be used for routine blood detection.

Therefore, for each sample container in the sample rack to be tested that is fed into the sample analysis system, it is necessary to identify its measurement mode. As shown in fig. 2, the sample analysis system may also generally include aloading platform 70 and aplatform loading mechanism 71. Theloading platform 70 is located at one end of the transmission channel, and theloading platform 70 is used for placing a sample rack to be tested. Theloading platform 70 is located at the front end of the transport direction X of the transport path, that is, the sample rack is moved from theloading platform 70 to the transport path, and then is transported to each analyzer through the transport path. Thestage loading mechanism 71 is used to transfer the sample rack on theloading stage 70 to the transfer passage. The sample rack to be tested placed on theloading platform 70 is typically first transported to a hematology analyzer for routine testing of blood, and for this reason, in one embodiment of the present application, at least one hematology analyzer includes a scanning device for obtaining measurement mode information of the sample container on the sample rack to be tested as the sample rack passes through the hematology analyzer.

When the measurement mode information indicates that a sample container requiring specific protein detection is placed on the sample rack to be detected, thecontrol device 30 controls the sample transfer device to transfer the sample rack to be detected, which has undergone routine blood detection, for example, routine first blood detection, to the detection area of one of the at least two specific protein analyzers according to the operation state information.

That is, the sample rack to be tested is first placed on theloading platform 70, the sample rack to be tested on theloading platform 70 is moved to the transmission channel by theplatform loading mechanism 71, and then the sample moving device first schedules the sample rack to be tested into the blood cell analyzer for routine blood testing, such as the first routine blood testing, and after the routine blood testing is finished, the sample moving device allocates and schedules the sample rack to be tested according to the operating status of a plurality of specific protein analyzers, such as the first scheduling into an idle specific protein analyzer. In some embodiments, when all of the specific protein analyzers of the sample analysis system are busy, the sample rack to be tested for routine testing of blood may be temporarily stored in the feeding mechanism of the blood cell analyzer to wait, and then scheduled when the specific protein analyzers are idle.

Correspondingly, each sample container on the sample rack to be measured can be provided with a measurement mode information identifier, and the measurement mode information identifier can be: the measurement mode information mark can also be a pattern mark with more information, such as a bar code, a two-dimensional code and the like.

When the sample container passes through the scanning device, the scanning device may acquire measurement mode information of the sample in the sample container on the sample rack to be measured, and then transmit the measurement mode information to thecontrol device 30 through the blood cell analyzer.

In some embodiments of the present application, a scanning device of a hematology analyzer can identify a sample rack and a sample barcode and store a sample in correspondence with its position on the sample rack. The specific protein analyzer can acquire the measurement mode of each sample on the sample rack by identifying the sample rack bar code through the corresponding relation between the sample and the sample rack established by the blood cell analyzer.

In a specific detection process, thecontrol device 30 may control the sample transfer device to transfer the sample rack to be detected to the blood cell analyzer with the scanning device, so as to perform a first routine blood detection, and simultaneously obtain measurement mode information of each sample container on the sample rack to be detected. Then, when thecontrol device 30 analyzes the measurement mode information and indicates that a sample container requiring specific protein detection is placed on the sample rack to be detected, thecontrol device 30 controls the sample transfer device to transfer the sample rack to be detected, which has undergone the first blood routine detection, to a detection area of one of at least two specific protein analyzers according to the operation state information.

In other embodiments, the scanning device may also be arranged independently of the blood cell analyzer, as shown in fig. 3, in which thescanning device 101 may be arranged separately on thetransport mechanism 41, the position of thescanning device 101 being in front of at least two specific protein analyzers in the transport direction X, and as shown in fig. 3, thescanning device 101 is connected directly to thecontrol device 30.

In other embodiments of the present application, a scanning device may also be disposed on theloading platform 70 to identify the sample rack and the sample barcode disposed on theloading platform 70, and to establish and store the corresponding relationship between the sample and the position of the sample on the sample rack. The blood cell analyzer and/or the specific protein analyzer can acquire the measurement mode of each sample on the sample rack by identifying the sample rack bar code through the corresponding relationship between the sample and the sample rack established by the scanning device on theloading platform 70.

In other embodiments of the present application, a scanning device may be further disposed in each specific protein analyzer, and the scanning device disposed in the specific protein analyzer is configured to scan the measurement mode information of the sample container on the sample rack to be tested again, so as to determine whether the sample container on the sample rack to be tested has the specific protein detection mode. The scanning device of the specific protein analyzer can only scan the sample container which is confirmed to have the specific protein measurement mode on the sample rack to be detected by the scanning device of the blood cell analyzer, and other sample containers which are confirmed to have no specific protein mode by the scanning device of the blood cell analyzer are not scanned and directly skipped, so that the measurement efficiency of the specific protein is improved.

Since the blood routine test data is the basis for medical staff to judge the physical condition of a subject, and when the specific protein analyzer is a whole blood specific protein analyzer (e.g., a whole blood CRP analyzer) that performs specific protein test using whole blood, it may be necessary to correct the whole blood specific protein test result using the blood routine test data, it is desirable that the blood routine test data be as accurate as possible. In order to improve the accuracy of the blood routine test data as much as possible, in an embodiment of the present application, thecontrol device 30 is electrically connected to each of the blood cell analyzers, and the blood routine test data is sent to thecontrol device 30 after each of the blood cell analyzers performs blood routine analysis.

Thecontrol device 30 analyses the received blood routine test data and arranges for blood routine review of a sample if it is determined that there is a problem with the blood routine test data of that sample.

In operation, thecontrol device 30 may determine a sample container whose blood routine test data meets a preset retest condition as a retest sample container, and determine one of the at least one hematology analyzer as a retest hematology analyzer for retesting the retest sample container.

After the recheck hemocytometer is determined, thecontrol apparatus 30 can transfer the recheck sample container to the recheck hemocytometer for routine recheck of blood.

In a specific application, if the sample rack to be tested includes a retest sample container and a sample container requiring specific protein detection, thecontrol device 30 may control the sample transfer device to transfer the sample rack to be tested, which has undergone the first blood routine detection, to the retest blood cell analyzer for performing the blood routine retest, and then control the sample transfer device to transfer the retest sample rack to be tested, which has undergone the blood routine retest, to the detection area of one of the at least two specific protein analyzers for performing the specific protein detection after the retest sample container on the sample rack to be tested is subjected to the blood routine retest.

The mode of preferentially performing routine blood retest on the sample rack to be detected which simultaneously comprises the retest sample container and the sample container needing specific protein detection and then performing specific protein detection can ensure that critical samples needing retest preferentially complete routine blood retest and timely send out routine blood reports on the basis of ensuring the quality.

In the above application scenario, in some embodiments, all of the blood cell analyzers of the sample analysis system are positioned in front of a particular protein analyzer in the transport direction along the transport channel, as shown in fig. 5. At this moment, can further guarantee that the reinspection sample container obtains timely conventional reinspection of blood, can guarantee promptly that critical value in time bleeds conventional report under the condition of quality priority promptly.

In another application, if the sample rack to be tested includes a retest sample container and a sample container that needs to be subjected to specific protein detection, thecontrol device 30 may further move the sample rack to be tested, which is subjected to the first blood routine detection, to the detection area of one of the at least two specific protein analyzers to perform specific protein detection, and then move the sample rack to be tested, which is subjected to the specific protein detection, to the retest blood cell analyzer to perform the blood routine retest. The sample rack to be detected, which simultaneously comprises the reinspection sample container and the sample container needing to carry out the specific protein detection, preferentially carries out the specific protein detection, and then carries out the routine reinspection of blood, so that the waiting time for the detection of the specific protein can be reduced, a specific protein detection report can be sent out as soon as possible, the specific protein detection is not influenced by the reinspection, namely, the specific protein detection efficiency is preferentially.

In the above application scenario, in some embodiments, the blood cell analyzer of the sample analysis system is interspersed with the specific protein analyzer in the transport direction along the transport channel, as shown in fig. 6. At this time, the sample on the sample rack to be detected can be further ensured to be transported to the nearest specific protein for specific protein detection as soon as possible after the first routine blood detection.

In some embodiments of the present application, the at least two hematology analyzers of the sample analysis system include at least one high match sphere analyzer and at least one low match sphere analyzer, and the high match sphere analyzer has a different, in particular more and/or better, test item than the low match sphere analyzer. The blood routine test items, i.e. blood routine test parameters, may include, for example: leukocyte detection (classification and/or counting), erythrocyte detection (classification and/or counting), NRBC (nuclear Red Blood Cell) detection, platelet impedance detection, platelet optical detection, reticulocyte detection, blast detection, malaria detection, and the like. For example, a low-match blood cell analyzer is configured to be capable of only conventional white blood cell detection (sorting and/or counting) and red blood cell detection (sorting and/or counting), platelet impedance detection, while a high-match blood cell analyzer is configured to be capable of white blood cell detection (sorting and/or counting), red blood cell detection (sorting and/or counting), NRBC detection, platelet impedance detection, platelet optics detection, reticulocyte detection, primitive cell detection, malaria detection. In the routine blood retest, in one case, the routine blood retest can be performed by using a hemocyte analyzer for the first routine blood test, and in the other case, the routine blood retest can be performed by using a hemocyte analyzer different from the first routine blood test.

In general, if the items of detection for routine blood retesting that need to be performed are the same as those for routine first-time blood retesting, any of the blood cell analyzers may be selected for routine blood retesting, and preferably the blood cell analyzer for routine first-time blood retesting (current blood cell analyzer) is selected for retesting, that is, the present analyzer is preferably used for retesting. However, if the detection items of the routine blood retest required to be performed are different from those of the first routine blood retest, a blood cell analyzer capable of realizing different detection items, typically a high-match blood cell analyzer, needs to be selected for routine blood retest.

For example, the samples on the sample rack to be tested are first subjected to routine blood testing in the low-match blood sample analyzer, and if thecontrol device 30 determines that some samples on the sample rack to be tested need routine blood retest with different testing items by analyzing the routine blood testing data of the low-match blood sample analyzer, thecontrol device 30 may control the sample moving device to move the sample rack to be tested to the high-match blood sample analyzer, so as to perform routine blood retest on the retest sample containers.

In concrete application, the assembly line transmission efficiency of the sample rack to be detected in the transmission channel is considered, the low blood distribution ball analyzer is located in front of the high blood distribution ball analyzer in the transmission direction along the transmission channel, and by the arrangement mode, samples on the sample rack to be detected can be sequentially transferred to the high blood distribution ball analyzer when blood routine reinspections of different detection items are needed, and directly enter the specific protein analyzer located behind the sample rack after the blood routine reinspections.

Therefore, in an embodiment of the present application, when performing routine blood retest on a sample, there may be at least two retest modes, and the at least two retest modes may include: the blood routine retest mode includes a same-item retest mode and an additional-item retest mode, where the same-item retest mode refers to that the first blood routine test and the second blood routine retest test are the same, and the detection item of the first blood routine test in the additional-item retest mode is different from the detection item of the blood routine retest, for example, the blood routine retest needs to detect a new detection item or needs to detect the same detection item again by using a different detection method, and in some embodiments, the same-item retest mode may also be referred to as: the original mode review mode, plus item attachment mode may also be referred to as: and (5) a non-original mode rechecking mode.

In a specific application, thecontrol device 30 is further configured to determine a retest mode of the retest sample container according to the blood routine detection data, and when the retest sample container with the retest mode being the same item retest mode is included in the to-be-detected sample rack, control the sample transfer device to transfer the to-be-detected sample rack to the hematology analyzer for performing the first blood routine detection on the retest sample container for retest; when the sample rack to be tested includes the retest sample container with the retest mode being the project retest mode, thecontrol device 30 controls the sample transfer device to transfer the sample rack to be tested to the matching blood ball analyzer for retest. For example: when the platelet impedance method detection result in the blood routine detection data shows that the low value abnormality of the platelets exists, the optical method is needed to perform retest on the platelets so as to determine whether the result of the low value abnormality of the platelets in the blood routine detection for the first time is accurate.

Further, as for the positional relationship between the blood cell analyzer and the specific protein analyzer, it may be set as follows:

at least one specific protein analyzer of the at least two specific protein analyzers is located between the low and high match ball analyzers.

Thus, for the control device, when the sample rack to be detected comprises the reinspection sample container with the reinspection mode being the project reinspection mode and the sample container needing to be subjected to the specific protein detection, that is, when two sample containers needing to be subjected to different detections are simultaneously arranged on the same sample rack to be detected, the sample transfer device is controlled to firstly convey the sample rack to be detected to the detection area corresponding to the specific protein analyzer arranged between the low blood distribution ball analyzer and the high blood distribution ball analyzer, and the specific protein detection is performed on the sample needing to be subjected to the specific protein detection; and then controlling the sample transfer equipment to transfer the sample rack to be detected to the high matching blood ball analyzer for rechecking after the specific protein detection is finished.

According to the arrangement mode of the specific protein analyzer and the blood cell analyzer, if 5 sample containers are arranged on a sample rack to be detected and samples in 2 sample containers need to be subjected to item adding retest after passing through the low-distribution blood cell analyzer, samples in other 3 sample containers do not need to be subjected to item adding retest, specific protein detection can be preferentially carried out on the samples which do not need to be subjected to the routine blood retest, and then the routine blood retest is carried out on the samples which need to be subjected to the routine blood retest, so that the samples in the sample rack to be detected can be rapidly subjected to specific protein detection, the specific protein detection can be carried out after the routine blood retest of all samples in the sample rack to be detected is not required, and the detection waiting time of the specific protein can be reduced.

An embodiment of the present application further provides a sample analysis system, which may include: one specific protein analyzer for specific protein detection, a sample transfer device, acontrol device 30 and at least two blood cell analyzers for routine blood detection. As shown in fig. 7, the graph includes: a firstblood cell analyzer 61, a secondblood cell analyzer 62, and a specific protein analyzer 21 (which may be a CRP analyzer that detects C-reactive protein).

The sample transfer device includes: atransport mechanism 41 having a transport path for transferring sample racks in which sample containers are placed, and at least threefeed mechanisms 42 having a detection path, thefeed mechanisms 41 being arranged at intervals along a transport direction of the transport path, thefeed mechanisms 42 being capable of transferring sample racks from the transport path to the detection path and of transferring sample racks from the detection path to the transport path. For the sample transfer device, reference may be made to the description of embodiment 1, and details are not repeated here.

Thespecific protein analyzer 21 and each of the blood cell analyzers correspond to one of the feedingmechanisms 42, and the detection areas of thespecific protein analyzer 21, the firstblood cell analyzer 61 and the secondblood cell analyzer 62 correspond to the detection channels of thecorresponding feeding mechanisms 42 respectively; and thespecific protein analyzer 21 is located between the firstblood cell analyzer 61 and the secondblood cell analyzer 62 in the transport direction along the transport channel.

Thecontrol device 30 is electrically connected to the sample transfer device and configured to acquire measurement mode information of the sample container on the sample rack to be tested, and control the sample transfer device to transfer the sample rack to be tested loaded with the sample to one or more of thespecific protein analyzer 21, the firstblood cell analyzer 61 and the secondblood cell analyzer 62 for corresponding detection according to the measurement mode information.

This application is this sample analysis system that this application embodiment provided, at least twofeed mechanism 42 are laid to the interval on transmission channel, in the direction of transmission along transmission channel, lay a specific protein analysis appearance and at least two blood cell analysis appearance, to the sample frame that awaits measuring, undertransmission mechanism 41's drive, on transmission channel,controlgear 30 can control the sample and move the equipment and move the sample frame that awaits measuring that will load the sample and move specific protein analysis appearance or arbitrary one blood cell analysis appearance and carry out corresponding detection, and then can carry out rational distribution to the sample frame, improve the detection efficiency of sample.

Further, since the blood routine test data is a basis for medical staff to judge the physical condition of the subject, and when the specific protein analyzer is a whole blood specific protein analyzer that performs specific protein test using whole blood, it may be necessary to correct the whole blood specific protein test result using the blood routine test data, it is necessary that the blood routine test data be as accurate as possible. In order to improve the accuracy of the blood routine test data as much as possible, in the embodiment of the present application, thecontrol device 30 is electrically connected to each of the blood cell analyzers, and the blood routine test data is sent to thecontrol device 30 after each of the blood cell analyzers performs blood routine analysis.

Thecontrol device 30 analyzes the received blood routine detection data, and controls the blood routine retest of the sample if the blood routine detection data of the sample in a certain sample container on the sample rack to be tested is determined to meet the preset retest condition.

In operation, thecontrol device 30 may determine a sample container whose blood routine test data meets a preset retest condition as a retest sample container, and determine one of the at least two hematology analyzers as a retest hematology analyzer for retesting the retest sample container. After the recheck hemocytometer is determined, thecontrol apparatus 30 can transfer the recheck sample container to the recheck hemocytometer for routine recheck of blood.

In a specific application, if the sample rack to be tested includes a retest sample container and a sample container requiring specific protein detection, thecontrol device 30 may control the sample transfer device to transfer the sample rack to be tested, which has undergone the first blood routine detection, to the retest blood cell analyzer for performing the blood routine retest, and then control the sample transfer device to transfer the retest sample rack to be tested, which has undergone the blood routine retest, to the detection area of the specific protein analyzer for performing the specific protein detection after performing the blood routine retest on the retest sample container on the sample rack to be tested.

The sample rack to be detected, which simultaneously comprises the reinspection sample container and the sample container needing to be subjected to specific protein detection, preferentially performs routine blood reinspection, and then performs specific protein detection, so that critical samples needing to be reinspected preferentially complete routine blood reinspection, and blood routine reports are timely sent out on the basis of ensuring the quality.

In another application, if the sample rack to be tested includes a retest sample container and a sample container that needs to be subjected to specific protein detection, thecontrol device 30 may further move the sample rack to be tested, which is subjected to the first blood routine detection, to the detection area of the specific protein analyzer to perform specific protein detection, and then move the sample rack to be tested, which is subjected to the specific protein detection, to the retest hematology analyzer to perform the blood routine retest.

The sample rack to be detected, which simultaneously comprises the reinspection sample container and the sample container needing to carry out the specific protein detection, preferentially carries out the specific protein detection, and then carries out the routine reinspection of blood, so that the waiting time for the specific protein detection can be reduced, a specific protein detection report can be sent out as soon as possible, the specific protein detection report is not influenced by the reinspection, namely, the specific protein efficiency is preferentially.

In the above application scenarios, in some embodiments, when performing routine blood retest, in one case, the routine blood retest may be performed by using a blood cell analyzer for first routine blood detection, and in another case, the routine blood retest may be performed by using a blood cell analyzer different from the first routine blood detection.

In general, if the items of detection for routine blood retesting that need to be performed are the same as those for routine first-time blood retesting, any of the blood cell analyzers may be selected for routine blood retesting, and preferably the blood cell analyzer for routine first-time blood retesting (current blood cell analyzer) is selected for retesting, that is, the present analyzer is preferably used for retesting. However, if the detection items of the routine blood retest required to be performed are different from those of the first routine blood retest, a blood cell analyzer capable of realizing different detection items, typically a high-match blood cell analyzer, needs to be selected for routine blood retest.

In some embodiments of the present application, at least two hematology analyzers include: the blood matching analysis system comprises at least one high blood matching ball analyzer and at least one low blood matching ball analyzer, wherein the detection items of the high blood matching ball analyzer are different from the detection items of the low blood matching ball analyzer.

Further, the sample on the sample rack to be tested is subjected to routine blood detection in the low blood matching sphere analyzer, and if thecontrol device 30 determines that some samples on the sample rack to be tested need routine blood reinspection with different detection items by analyzing routine blood detection data of the low blood matching sphere analyzer, thecontrol device 30 may control the sample moving device to transfer the sample rack to be tested to the high blood matching sphere analyzer, so as to perform routine blood reinspection on the reinspected sample container.

In a specific application, in consideration of the efficiency of the assembly line transmission of the sample rack to be tested in the transmission channel, the specific protein analyzer is located after the low-match blood cell analyzer and before the high-match blood cell analyzer in the transmission direction along the transmission channel. Thus, when the sample rack to be tested includes the retest sample container with the retest mode being the project retest mode and the sample container requiring specific protein detection, that is, when two sample containers requiring different detections are simultaneously present on the same sample rack to be tested, thecontrol device 30 controls the sample transfer device to transfer the sample rack to be tested to the detection area corresponding to the specific protein analyzer located between the low blood distribution globe analyzer and the high blood distribution globe analyzer, and performs specific protein detection on the sample requiring specific protein detection; and then controlling the sample transfer equipment to transfer the sample rack to be detected to the high matching blood ball analyzer for rechecking after the specific protein detection is finished.

In some embodiments of the present application, on the basis of fig. 7, other analyzers may be further disposed along the conveying direction of the conveying channel of the conveyingmechanism 41, and these are all within the scope of the present application.

In some embodiments of the present application, as shown in fig. 8, a schematic structural diagram of a control device provided in the embodiments of the present application is shown. Thecontrol device 30 comprises at least: processingcomponent 31, RAM112, ROM113,communication interface 34,memory 36, and I/O interface 35, whereprocessing component 31, RAM32, ROM33,communication interface 34,memory 36, and I/O interface 35 communicate overbus 37.

The processing component may be a CPU, GPU or other chip with computing capabilities.

Thememory 36 stores therein various computer programs such as an operating system and an application program to be executed by theprocessor unit 31, and data necessary for executing the computer programs. In addition, data stored locally during the sample testing process, if desired, may be stored inmemory 36.

The I/O interface 35 is constituted by a serial interface such as USB, IEEE1394, or RS-232C, a parallel interface such as SCSI, IDE, or IEEE1284, and an analog signal interface composed of a D/a converter and an a/D converter. The I/O interface 35 is connected to an input device comprising a keyboard, mouse, touch screen or other control buttons, and a user can directly input data to thecontrol device 30 using the input device. In addition, a display having a display function, such as: liquid crystal screen, touch screen, LED display screen, etc., thecontrol device 30 may output the processed data as image display data to a display for display, for example: analytical data, instrument operating parameters, etc.

Thecommunication interface 34 is an interface that may be any communication protocol known today. Thecommunication interface 34 communicates with the outside through a network. Thecontrol device 30 may communicate data with any of the devices connected through the network via thecommunication interface 34 in a communication protocol.

It is noted that, in this document, relational terms such as "first" and "second," and the like, may be used solely to distinguish one entity or action from another entity or action without necessarily requiring or implying any actual such relationship or order between such entities or actions. Also, the terms "comprises," "comprising," or any other variation thereof, are intended to cover a non-exclusive inclusion, such that a process, method, article, or apparatus that comprises a list of elements does not include only those elements but may include other elements not expressly listed or inherent to such process, method, article, or apparatus. Without further limitation, an element defined by the phrase "comprising an … …" does not exclude the presence of other identical elements in a process, method, article, or apparatus that comprises the element.

The individual features described in the individual embodiments of the description, the figures and the claims can be combined in any way as far as they are meaningful and not mutually contradictory within the scope of the present application.

The foregoing are merely exemplary embodiments of the present invention, which enable those skilled in the art to understand or practice the present invention. Various modifications to these embodiments will be readily apparent to those skilled in the art, and the generic principles defined herein may be applied to other embodiments without departing from the spirit or scope of the invention. Thus, the present invention is not intended to be limited to the embodiments shown herein but is to be accorded the widest scope consistent with the principles and novel features disclosed herein.

Claims (24)

1. A sample analysis system, comprising: at least two specific protein analyzers for specific protein detection, a sample transfer device, and a control device, wherein,

the sample transfer apparatus includes: the sample rack conveying device comprises a conveying mechanism with a conveying channel and at least two feeding mechanisms with a detection channel, wherein the conveying mechanism is used for transferring sample racks with sample containers in the conveying channel, each feeding mechanism is arranged at intervals along the conveying direction of the conveying channel, and the feeding mechanisms can transfer the sample racks from the conveying channel to the detection channel and transfer the sample racks from the detection channel to the conveying channel;

each specific protein analyzer corresponds to one feeding mechanism, and the detection area of each specific protein analyzer corresponds to the detection channel of the corresponding feeding mechanism;

the at least two specific protein analyzers are configured to detect at least one identical specific protein;

the control device is electrically connected to each of the specific protein analyzer and the sample transfer device and configured to: and when the measurement mode information indicates that a sample container needing to be subjected to specific protein detection is placed on the sample rack to be detected, controlling the sample transfer equipment to transfer the sample rack to be detected to a detection area of one of the at least two specific protein analyzers according to the operation state information.

2. The sample analysis system of claim 1, wherein the operational status information comprises detection load information for each specific protein analyzer;

the control device is used for controlling the sample transfer device to transfer the sample rack to be detected to a detection area of a specific protein analyzer with a smaller detection load in the at least two specific protein analyzers according to the detection load information of each specific protein analyzer.

3. The sample analysis system of claim 2, wherein the control device is further configured to: determining the waiting time of the sample rack to be detected according to the detection load information of each specific protein analyzer, and controlling the sample transfer equipment to transfer the sample rack to be detected to a detection area of a specific protein analyzer with a smaller detection load in the at least two specific protein analyzers after the waiting time.

4. The sample analysis system of claim 3, further comprising an unloading platform and other analyzers different from the at least two specific protein analyzers, the control device further configured to: and when the waiting time is longer than the preset time, controlling the sample transfer equipment to transfer the sample rack to be tested to the unloading platform or other analyzers.

5. The sample analysis system according to any one of claims 1 to 4, wherein the sample analyzer system further comprises at least one hematology analyzer for routine testing of blood, each of the hematology analyzers corresponds to one of the feed mechanisms, and the detection area of each of the hematology analyzers corresponds to the detection channel of its corresponding feed mechanism.

6. The sample analysis system of claim 5, wherein the at least one hematology analyzer is positioned in front of the at least two specific protein analyzers in a transport direction along the transport channel.

7. The sample analysis system according to claim 5 or 6, wherein the at least one hematology analyzer comprises a scanning device for obtaining measurement mode information of the sample container on the sample rack to be tested;

the control device is used for controlling the sample transfer device to transfer the sample rack to be detected to one of the blood cell analyzers for primary blood routine detection and acquiring measurement mode information of a sample container on the sample rack to be detected, and when the measurement mode information indicates that the sample container needing specific protein detection is placed on the sample rack to be detected, controlling the sample transfer device to transfer the sample rack to be detected, which is subjected to primary blood routine detection, to a detection area of one of the at least two specific protein analyzers according to the operation state information.

8. The sample analysis system according to claim 7, wherein the at least two specific protein analyzers each comprise a scanning device for confirming measurement mode information of the sample container on the sample rack to be tested.

9. The sample analysis system according to any one of claims 5 to 8, further comprising a loading platform located before the at least one hematology analyzer in the transport direction along the transport channel and configured to place a sample rack to be tested, and a platform loading mechanism configured to move a sample rack on the loading platform to the transport channel; and the loading platform is provided with a scanning device for identifying the sample rack placed on the loading platform and the sample identifier, and establishing and storing the corresponding relation between the sample identifier and the sample rack position.

10. The sample analysis system of any one of claims 5 to 9, wherein the control device is electrically connected to each of the hematology analyzers and is configured to obtain blood routine test data for each of the hematology analyzers;

the control equipment is also used for determining a sample container with blood routine detection data meeting preset rechecking conditions as a rechecking sample container, and determining one of the at least one hematology analyzer as a rechecking hematology analyzer for rechecking the rechecking sample container.

11. The sample analysis system according to claim 10, wherein the control device is configured to, when the sample rack to be tested includes a retest sample container and a sample container requiring specific protein detection thereon, control the sample transfer device to transfer the sample rack to be tested, which has undergone a first blood routine test, to the retest hemocytometer for a blood routine retest, and then control the sample transfer device to transfer the retest sample rack to be tested to the detection area of one of the at least two specific protein analyzers after the blood routine retest of the retest sample container on the sample rack to be tested.

12. The sample analysis system according to claim 10, wherein the control device is configured to, when the sample rack to be tested includes a retest sample container and a sample container requiring specific protein detection thereon, control the sample transfer device to move the sample rack to be tested, which has undergone a first blood routine test, to a detection area of one of the at least two specific protein analyzers for specific protein detection, and then to transfer the sample rack to be tested, which has undergone specific protein detection, to the retest hematology analyzer for blood routine retest.

13. The sample analysis system of any one of claims 5 to 12, wherein the sample analyzer system comprises at least two hematology analyzers for routine testing of blood;

at least one of the at least two hematology analyzers is positioned in front of the at least two specific protein analyzers in the transport direction along the transport channel.

14. The sample analysis system of claim 13, wherein the at least two hematology analyzers comprise: at least one high blood matching sphere analyzer and at least one low blood matching sphere analyzer, wherein the detection items of the high blood matching sphere analyzer are different from the detection items of the low blood matching sphere analyzer;

the low match sphere analyzer is positioned in front of the high match sphere analyzer in a direction of transport along the transport channel.

15. The sample analysis system of claim 14, wherein the control device is further configured to:

electrically connected to each of said hematology analyzers and configured for obtaining blood routine test data for each of said hematology analyzers;

determining a sample container of which the blood routine detection data meet preset rechecking conditions as a rechecking sample container and determining a rechecking mode of the rechecking sample container, wherein the rechecking mode comprises a same-item rechecking mode and an additional-item rechecking mode;

when the sample rack to be detected comprises a retest sample container with a retest mode being the same item retest mode, controlling the sample transfer equipment to transfer the sample rack to be detected to a hematology analyzer for performing primary routine blood detection on the retest sample container for retest;

and when the sample rack to be detected comprises a retest sample container with a retest mode being an item retest mode, controlling the sample transfer equipment to transfer the sample rack to be detected to the high blood matching ball analyzer for retest.

16. The sample analysis system of claim 15, wherein at least one of the at least two specific protein analyzers is located between the low and high hematocrit analyzers in a transport direction along the transport channel;

the control device is used for controlling the sample transfer equipment to convey the sample rack to be detected to the specific protein analyzer positioned between the low blood distribution globe analyzer and the high blood distribution globe analyzer when the sample rack to be detected comprises a retest sample container with a retest mode being an item retest mode and a sample container needing specific protein detection, and controlling the sample transfer equipment to transfer the sample rack to be detected to the high blood distribution globe analyzer for retest after specific protein detection is finished.

17. The sample analysis system according to any one of claims 1 to 16, wherein the at least two specific protein analyzers are selected from the group consisting of a C-reactive protein analyzer, a serum amyloid a analyzer, a procalcitonin analyzer, and other specific protein analyzers, or comprise two or more integrated machines thereof.

18. A sample analysis system, comprising: a specific protein analyzer for specific protein detection, a sample transfer device, a control device and at least two blood cell analyzers for routine blood detection, wherein,

the sample transfer apparatus includes: the sample rack conveying device comprises a conveying mechanism with a conveying channel and at least three feeding mechanisms with detection channels, wherein the conveying mechanism is used for transferring sample racks with sample containers in the conveying channel, each feeding mechanism is arranged at intervals along the conveying direction of the conveying channel, and the feeding mechanisms can transfer the sample racks from the conveying channel to the detection channels and transfer the sample racks from the detection channels to the conveying channel;

the specific protein analyzer and each blood cell analyzer correspond to one feeding mechanism, and the detection areas of the specific protein analyzer and each blood cell analyzer correspond to the detection channels of the feeding mechanisms corresponding to the specific protein analyzer and each blood cell analyzer respectively;

the specific protein analyzer is located between the at least two hematology analyzers in a transport direction along the transport channel;

the control device is electrically connected with the sample transfer device and configured to: and acquiring measurement mode information of a sample container on a sample rack to be detected, and controlling the sample transfer equipment to transfer the sample rack to be detected loaded with the sample to the specific protein analyzer and/or any one of the blood cell analyzers according to the measurement mode information to perform corresponding detection.

19. The sample analysis system of claim 18, wherein the control device is electrically connected to each of the hematology analyzers and is configured to obtain blood routine test data for each of the hematology analyzers;

the control equipment is also used for determining a sample container with blood routine detection data meeting preset rechecking conditions as a rechecking sample container, and determining one of the at least two blood cell analyzers as a rechecking blood cell analyzer for rechecking the rechecking sample container.

20. The sample analysis system according to claim 19, wherein the control device is configured to, when the sample rack to be tested includes a retest sample container and a sample container requiring specific protein detection, control the sample transfer device to transfer the sample rack to be tested to the retest hematology analyzer for routine retest, and then control the sample transfer device to transfer the retest sample rack to be tested to the detection area of the specific protein analyzer for specific protein detection after routine retest is performed on the retest sample container on the sample rack to be tested.

21. The sample analysis system according to claim 19, wherein the control device is configured to, when the sample rack to be tested includes a retest sample container and a sample container requiring a specific protein detection, control the sample transfer device to move the sample rack to be tested to the detection area of the specific protein analyzer for the specific protein detection, and then transfer the sample rack to be tested, which is detected by the specific protein, to the retest hematology analyzer for a blood routine retest.

22. The sample analysis system of any one of claims 18 to 21, wherein the at least two hematology analyzers comprise: at least one high blood matching sphere analyzer and at least one low blood matching sphere analyzer, wherein the detection items of the high blood matching sphere analyzer are different from the detection items of the low blood matching sphere analyzer;

the low match sphere analyzer is positioned in front of the high match sphere analyzer in a direction of transport along the transport channel.

23. The sample analysis system of claim 22, wherein the control device is further configured to:

electrically connected to each of said hematology analyzers and configured for obtaining blood routine test data for each of said hematology analyzers;

determining a sample container of which the blood routine detection data meet preset rechecking conditions as a rechecking sample container and determining a rechecking mode of the rechecking sample container, wherein the rechecking mode comprises a same-item rechecking mode and an additional-item rechecking mode;

when the sample rack to be detected comprises a retest sample container with a retest mode being the same item retest mode, controlling the sample transfer equipment to transfer the sample rack to be detected to a hematology analyzer for performing primary routine blood detection on the retest sample container for retest;

and when the sample rack to be detected comprises a retest sample container with a retest mode being an item retest mode, controlling the sample transfer equipment to transfer the sample rack to be detected to the high blood matching ball analyzer for retest.

24. The sample analysis system of claim 23, wherein the specific protein analyzer is located after the low hematocrit analyzer and before the high hematocrit analyzer in the transport direction along the transport channel;

the control device is used for controlling the sample transfer equipment to convey the sample rack to be detected to the specific protein analyzer when the sample rack to be detected comprises a reinspection sample container with an item reinspection mode and a sample container needing specific protein detection, and controlling the sample transfer equipment to transfer the sample rack to be detected to the high-match hematology analyzer for reinspection after the specific protein detection is finished.

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