CN113262396B - Method for improving temperature distribution of photothermal effect - Google Patents
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Abstract
Translated fromChinese
Description
Translated fromChinese技术领域technical field
本发明涉及光热效应技术领域，尤其是涉及一种改善光热效应温度分布的方法。The invention relates to the technical field of photothermal effect, in particular to a method for improving temperature distribution of photothermal effect.
背景技术Background technique
光热效应指材料受光照射后，光子能量与晶格相互作用，振动加剧，温度升高，由于温度的变化而造成物质的电学特性。光热效应在各个技术领域中得到广泛的应用，例如材料加工、局部消融等，以下就恶性肿瘤的消融为例对其现有技术中的应用进行说明。The photothermal effect means that after the material is irradiated by light, the photon energy interacts with the crystal lattice, the vibration is intensified, the temperature rises, and the electrical properties of the substance are caused by the temperature change. The photothermal effect is widely used in various technical fields, such as material processing, local ablation, etc. The following uses the ablation of malignant tumors as an example to illustrate its application in the prior art.
恶性肿瘤一直是人类健康的最大威胁之一，而目前传统的治疗手段存在治疗不彻底的问题且伴随严重的副作用。所以面对恶性肿瘤的威胁，我们急需新的治疗手段来赋予生命更多的可能性。近几年，光热治疗（Photothermal therapy, PPT）成为在临床上继手术、放疗和化疗之后的又一具有很大潜力的肿瘤治疗新手段。这种治疗方式可以减少患者所经受的疼痛，治疗时间短，治疗效果明显，且对人体副作用小。光热治疗的原理是将具有光热转换功能的材料注入人体，然后运用靶向识别技术可以将光热转换材料聚集在肿瘤内，最后在外部激光照射下，通过光热效应将光能转化为热能使局部温度升高，利用肿瘤细胞的不耐热性来达到治疗的效果。Malignant tumors have always been one of the greatest threats to human health, and the current traditional treatment methods have problems of incomplete treatment and severe side effects. Therefore, in the face of the threat of malignant tumors, we urgently need new treatments to give life more possibilities. In recent years, photothermal therapy (PPT) has become another new method of tumor treatment with great potential after surgery, radiotherapy and chemotherapy in clinical practice. This treatment method can reduce the pain suffered by the patient, has short treatment time, obvious treatment effect, and little side effects on the human body. The principle of photothermal therapy is to inject materials with photothermal conversion function into the human body, and then use targeted recognition technology to gather photothermal conversion materials in tumors, and finally convert light energy into heat energy through photothermal effect under external laser irradiation Raise the local temperature and use the heat intolerance of tumor cells to achieve the therapeutic effect.
然而光热效应容易受到光热转换对象大小、材质的影响而出现温度不均匀的情况，影响其加工效果。例如在光热治疗过程中常常会出现温度分布不均匀和表面过热等问题，使得光热治疗的效率不理想，光热治疗不能在临床上得到广泛应用，因此光热治疗过程中温度分布的调控对于推动光热治疗的应用至关重要。也就是说，改善光热效应中光热转换对象温度分布的均匀性对于推动光热效应的使用具有积极的意义。然而现有技术中的光照模式覆盖光热转换对象难以实现对温度分布的控制。However, the photothermal effect is easily affected by the size and material of the photothermal conversion object, resulting in uneven temperature, which affects its processing effect. For example, problems such as uneven temperature distribution and surface overheating often occur in the process of photothermal therapy, which makes the efficiency of photothermal therapy unsatisfactory, and photothermal therapy cannot be widely used clinically. Therefore, the regulation of temperature distribution in the process of photothermal therapy It is crucial to advance the application of photothermal therapy. That is to say, improving the uniformity of the temperature distribution of the photothermal conversion object in the photothermal effect has positive significance for promoting the use of the photothermal effect. However, the illumination mode in the prior art covers the light-to-heat conversion object and it is difficult to control the temperature distribution.
发明内容Contents of the invention
基于此，本发明的目的在于，提供一种改善光热效应温度分布的方法以提高光热效应的效率。Based on this, the object of the present invention is to provide a method for improving the temperature distribution of the photothermal effect so as to increase the efficiency of the photothermal effect.
本发明采取的技术方案如下：The technical scheme that the present invention takes is as follows:
一种改善光热效应温度分布的方法，包括以下步骤：将多光束垂直照射在光热转换对象的表面上以形成由圆光斑组成的光环；调节垂直照射在光热转换对象的表面上的光束参数，所述光束参数包括各个光束的照射波长、光环环数、每圈光环上的圆光斑数量、各个圆光斑半径、光束照射位置以及照射强度。A method for improving the temperature distribution of the photothermal effect, comprising the steps of: vertically irradiating multiple beams on the surface of the photothermal conversion object to form a halo composed of circular spots; adjusting the parameters of the beams vertically irradiated on the surface of the photothermal conversion object , the beam parameters include the irradiation wavelength of each beam, the number of halo rings, the number of circular spots on each circle of the halo, the radius of each circular spot, the irradiation position of the beam, and the irradiation intensity.
与现有技术相比较，本发明的改善光热效应温度分布的方法通过多光束环形光照模式均匀投射到光热转换对象的表面上的光束，且根据光照效果对光束参数进行调整，保证按照要求进行加热的同时，提高光热效应的效率。Compared with the prior art, the method for improving the temperature distribution of the photothermal effect of the present invention uses the multi-beam ring illumination mode to uniformly project the beam on the surface of the photothermal conversion object, and adjusts the beam parameters according to the illumination effect to ensure that the light is carried out according to the requirements. While heating, the efficiency of photothermal effect is improved.
进一步，将多光束垂直照射在光热转换对象的表面上以形成由圆光斑组成的光环前还包括以下步骤：预设光束的各初始参数且在光热转换对象中注入光热转换材料；所述初始参数包括预设光束的初始照射波长、初始照射强度、初始光束数、初始光环排列形状、初始光束半径以及初始光束照射位置，并保证投射光热转换对象的表面上的各个圆光斑不重叠，以确保投射的效果。Further, before vertically irradiating multiple beams on the surface of the photothermal conversion object to form a halo composed of circular spots, the following steps are included: preset the initial parameters of the beams and inject the photothermal conversion material into the photothermal conversion object; The above initial parameters include the initial irradiation wavelength of the preset beam, the initial irradiation intensity, the initial number of beams, the initial halo arrangement shape, the initial beam radius and the initial beam irradiation position, and ensure that the circular spots on the surface of the projected light-to-heat conversion object do not overlap , to ensure the projection effect.
进一步，若所述光热转换对象的厚度与最大长度的比值大于等于0.4，则所述初始光束照射位置靠近所述光热转换对象的边缘处；若所述光热转换对象的厚度与最大长度的比值小于0.4，则所述初始光束照射位置靠近所述光热转换对象的中心轴。根据光热转换对象的厚度调节初始光束照射位置，使得光热转换对象整体产热与散热均匀，均匀整体的温度分布。Further, if the ratio of the thickness of the photothermal conversion object to the maximum length is greater than or equal to 0.4, the initial beam irradiation position is close to the edge of the photothermal conversion object; if the thickness of the photothermal conversion object and the maximum length The ratio of is less than 0.4, the initial beam irradiation position is close to the central axis of the light-to-heat conversion object. Adjust the initial beam irradiation position according to the thickness of the light-to-heat conversion object, so that the overall heat generation and heat dissipation of the light-to-heat conversion object is uniform, and the overall temperature distribution is uniform.
进一步，所述初始照射波长为所述光热转换材料的共振波峰±10nm且照射过程中不改变。照射波长的选择应根据光热转换材料的光学性质、大小、形状等因素而定，并利用Mie散射理论、离散偶极子近似方法等数值方法计算，所获得的该初始照射波长值能优化光热转换材料的效率。Further, the initial irradiation wavelength is within ±10 nm of the resonant peak of the photothermal conversion material and does not change during the irradiation process. The selection of the irradiation wavelength should be determined according to the optical properties, size, shape and other factors of the photothermal conversion material, and it should be calculated by numerical methods such as Mie scattering theory and discrete dipole approximation method. Efficiency of heat conversion materials.
进一步，所述初始光环排列形状的参数包括环数；所述环数为1到3圈。光环的圈数不宜太多，让光束形成的圆光斑组成环形的目的是让光分散以实现温度分布对称。若圈数太多不利于进一步的调节，容易导致光束重叠的现象。Further, the parameters of the shape of the initial halo arrangement include the number of rings; the number of rings is 1 to 3 rings. The number of rings of the halo should not be too many. The purpose of making the circular spot formed by the beam form a ring is to disperse the light to achieve a symmetrical temperature distribution. If the number of turns is too many, it is not conducive to further adjustment, and it is easy to cause beam overlap.
进一步，所述初始光环排列形状的参数还包括各光束形成的初始圆光斑半径；所述初始圆光斑半径为所述光热转换对象半径的到。初始圆光斑半径不宜太大，过大容易造成光束重叠，引起温度不均匀，较小的圆光斑则在调节光束位置时会更灵活。Further, the parameters of the shape of the initial light ring arrangement also include the radius of the initial circular spot formed by each light beam; the initial circular spot radius is the radius of the light-to-heat conversion object. The initial radius of the circular spot should not be too large. If it is too large, it will easily cause the beams to overlap and cause uneven temperature. A smaller circular spot will be more flexible when adjusting the beam position.
进一步，所述初始光环排列形状的参数还包括组成各圈光环的光束数量；每圈光束数量为6到12个。各圈光环的光束数量不宜太少或太多，数量太少，容易造成温度分布不对称，不利于提高光热效应的效果，而数量过多又会引起光束重叠。Further, the parameter of the shape of the initial halo arrangement also includes the number of light beams forming each circle of halo; the number of light beams in each circle is 6 to 12. The number of light beams in each circle of halo should not be too small or too many. If the number is too small, it will easily cause asymmetrical temperature distribution, which is not conducive to improving the effect of photothermal effect, and if the number is too large, the beams will overlap.
进一步，各圈光环上的光束数量和/或各圈的初始圆光斑半径不相等。若所述光热转换对象的厚度与最大长度的比值较大时，靠近中心轴的内圈光束形成的圆光斑的数量相对外圈多一些且大小可以相对外圈大一些；若所述光热转换对象的厚度与最大长度的比值较小时，远离中心轴的外圈光束形成的圆光斑的数量可以相对内圈多一些且大小可以相对内圈大一些，以进一步均匀温度分布。Further, the number of light beams on each ring of light and/or the radius of the initial circular light spot of each ring are not equal. If the ratio of the thickness of the light-to-heat conversion object to the maximum length is large, the number of circular spots formed by the inner beam near the central axis is larger than that of the outer circle, and the size can be larger than that of the outer circle; if the light-to-heat When the ratio of the thickness of the converted object to the maximum length is small, the number and size of the circular spots formed by the outer beam far away from the central axis can be larger than that of the inner circle, so as to further uniform temperature distribution.
进一步，在调节垂直照射在光热转换对象的表面上的可调节光束参数前获取所述光热转换对象上的温度；根据所述光热转换对象上的温度调整所述光束照射位置。对多光束环形光进行预设后，若光热转换对象顶部边缘的温度比底部中心高，需进一步向内移动光束照射位置；若光热转换对象顶部边缘的温度比底部中心低，需进一步向外移动光束照射位置。当光热转换对象顶部边缘的温度与底部中心相同时，为最佳照射位置无需移动。移动光束位置过程中，光束形成的圆光斑不重叠且始终全部照射在光热转换对象顶部。Further, the temperature on the light-to-heat conversion object is obtained before adjusting the adjustable light beam parameters vertically irradiated on the surface of the light-to-heat conversion object; the irradiation position of the light beam is adjusted according to the temperature on the light-to-heat conversion object. After presetting the multi-beam ring light, if the temperature of the top edge of the photothermal conversion object is higher than that of the bottom center, the beam irradiation position needs to be moved further inward; if the temperature of the top edge of the photothermal conversion object is lower than the bottom center, it needs to be further moved Move the beam irradiation position outside. When the temperature of the top edge of the light-to-heat conversion object is the same as that of the bottom center, the optimal irradiation position does not need to be moved. During the process of moving the position of the beam, the circular spot formed by the beam does not overlap and is always irradiated on the top of the light-to-heat conversion object.
进一步，所述照射强度大于所述初始照射强度，以确保能获取所需温度。Further, the irradiation intensity is greater than the initial irradiation intensity to ensure that the desired temperature can be obtained.
为了更好地理解和实施，下面结合附图详细说明本发明。For better understanding and implementation, the present invention will be described in detail below in conjunction with the accompanying drawings.
附图说明Description of drawings
图1为本发明中改善光热效应温度分布方法的流程示意图；Fig. 1 is a schematic flow chart of the method for improving the temperature distribution of the photothermal effect in the present invention;
图2为本发明实施例中光热转换对象的结构示意图；Fig. 2 is a schematic structural diagram of a light-to-heat conversion object in an embodiment of the present invention;
图3为本发明实施例中沿光束投射方向投影光热转换对象的投影图；Fig. 3 is a projection diagram of projecting light-to-heat conversion objects along the beam projection direction in an embodiment of the present invention;
图4为本发明实施例1中现有技术的工作示意图及其温度分布图；Fig. 4 is the working schematic diagram and temperature distribution diagram thereof of prior art in
图5为本发明实施例1中多光束环形光照模式下沿光束投射方向投影光热转换对象的投影图及其温度分布图；5 is a projection diagram and temperature distribution diagram of projecting light-to-heat conversion objects along the beam projection direction under the multi-beam ring illumination mode in
图6为本发明实施例1中调整光束照射位置后沿光束投射方向投影光热转换对象的投影图及其温度分布图；6 is a projection diagram and a temperature distribution diagram of projecting light-to-heat conversion objects along the beam projection direction after adjusting the beam irradiation position in
图7为本发明实施例1中增强照射强度后沿光束投射方向投影光热转换对象的投影图及其温度分布图；Fig. 7 is a projection diagram and a temperature distribution diagram of projecting light-to-heat conversion objects along the beam projection direction after enhancing the irradiation intensity in
图8为本发明实施例2中现有技术的工作示意图及其温度分布图；Fig. 8 is a working schematic diagram and a temperature distribution diagram of the prior art in
图9为本发明实施例2中多光束环形光照模式下沿光束投射方向投影光热转换对象的投影图及其温度分布图；9 is a projection diagram and a temperature distribution diagram of projecting light-to-heat conversion objects along the beam projection direction under the multi-beam ring illumination mode in
图10为本发明实施例2中调整光束照射位置后沿光束投射方向投影光热转换对象的投影图及其温度分布图；10 is a projection diagram and a temperature distribution diagram of projecting light-to-heat conversion objects along the beam projection direction after adjusting the beam irradiation position in
图11为本发明实施例2中增强照射强度后沿光束投射方向投影光热转换对象的投影图及其温度分布图；Fig. 11 is a projection diagram and a temperature distribution diagram of the light-to-heat conversion object projected along the beam projection direction after the irradiation intensity is enhanced in
具体实施方式Detailed ways
本发明提供了一种改善光热效应温度分布的方法，该方法通过多光束环形光照模式来改善光热效应温度分布。具体地，请参阅图1，通过以下步骤实现：The invention provides a method for improving the temperature distribution of the photothermal effect, and the method improves the temperature distribution of the photothermal effect through a multi-beam ring illumination mode. Specifically, please refer to Figure 1, through the following steps:
步骤S10：设置光束发射器并预设光束的各初始参数，且在光热转换对象中注入光热转换材料。Step S10: setting up the beam emitter and preset the initial parameters of the beam, and injecting the light-to-heat conversion material into the light-to-heat conversion object.
预设光束初始参数包括预设光束的初始照射波长、初始照射强度、初始光束数、初始光环排列形状、初始光束半径以及初始光束照射位置。其中，所述初始光环排列形状的参数包括环数、组成各个光环的光束数量以及各光束形成的初始圆光斑半径，且在保证各个圆光斑不发生重叠的前提下，组成各个光环的光束数量可不相等；所述初始照射波长可根据Mie散射理论、离散偶极子近似方法等数值方法计算得到，且在光热效应过程中不改变。优选地，所述初始光环排列形状的环数为1至3圈，各光环上的光束数量为6到12个，每个光束半径设置为使得在光热转换对象上投射所得的圆光斑半径为光热转换对象接收光照的横截面半径到；光束初始照射位置根据光热转换对象厚度而定，设光热转换对象在光束投射方向上的距离为厚度H，在光束投射方向垂直的方向上最大距离为长度L，如果H/L大于等于0.4，则光束初始照射位置应靠近所述光热转换对象的边缘处；如果H/L小于0.4，则光束初始照射位置应靠近所述光热转换对象的中心轴；所述初始照射波长为光热转换材料的共振波峰±10nm，且照射过程中不改变。The initial parameters of the preset beam include the initial irradiation wavelength of the preset beam, the initial irradiation intensity, the initial number of beams, the initial arrangement shape of the halo, the initial beam radius, and the initial beam irradiation position. Wherein, the parameters of the shape of the initial halo arrangement include the number of rings, the number of beams forming each halo, and the radius of the initial circular spot formed by each beam, and under the premise that each circular spot does not overlap, the number of beams forming each halo can be different. equal; the initial irradiation wavelength can be calculated according to numerical methods such as Mie scattering theory and discrete dipole approximation method, and does not change during the process of photothermal effect. Preferably, the number of rings in the shape of the initial halo arrangement is 1 to 3, the number of beams on each halo is 6 to 12, and the radius of each beam is set so that the radius of the circular spot projected on the light-to-heat conversion object is The radius of the cross-section of the light-to-heat conversion object receiving the light is ≤ ; the initial irradiation position of the beam is determined according to the thickness of the light-to-heat conversion object. Let the distance of the light-to-heat conversion object in the beam projection direction be the thickness H, which is the largest in the direction perpendicular to the beam projection direction The distance is the length L, if H/L is greater than or equal to 0.4, the initial irradiation position of the beam should be close to the edge of the photothermal conversion object; if H/L is less than 0.4, the initial irradiation position of the beam should be close to the photothermal conversion object central axis; the initial irradiation wavelength is within ±10 nm of the resonant peak of the photothermal conversion material, and does not change during the irradiation process.
步骤S20：发射多光束并垂直照射在光热转换对象的表面上形成由圆光斑组成的光环实现多光束环形光照模式，并检测所述光热转换对象上的温度。Step S20: emit multiple beams and vertically irradiate on the surface of the light-to-heat conversion object to form a halo composed of circular light spots to realize the multi-beam ring illumination mode, and detect the temperature on the light-to-heat conversion object.
多光束垂直照射在光热转换对象的表面上时，每束光均形成一个圆光斑，各个圆光斑规则分布进一步排列为环形以组成光环。光热转换材料在光照下进行光热转换产生热量，热量的传递引起光热转换对象温度升高。When multiple light beams are vertically irradiated on the surface of the light-to-heat conversion object, each beam of light forms a circular spot, and each circular spot is regularly distributed and further arranged in a ring to form a halo. The photothermal conversion material performs photothermal conversion under light to generate heat, and the transfer of heat causes the temperature of the photothermal conversion object to rise.
步骤S30：根据光热转换对象的温度变化调节垂直照射在光热转换对象的表面上的可调节光束参数，通过改变热量的分布改变光热转换对象上的温度分布。Step S30: Adjust the parameters of the adjustable light beam vertically irradiated on the surface of the light-to-heat conversion object according to the temperature change of the light-to-heat conversion object, and change the temperature distribution on the light-to-heat conversion object by changing the heat distribution.
所述可调节光束参数包括各个光束的照射波长、光环环数、每个光环上的圆光斑数量、各个圆光斑半径、光束照射位置以及照射强度。所述光束照射位置包括各个光环半径。通过调节可调节光束参数控制光热转换对象内热量产生的位置以及强度，影响了热量的分布，从而改变温度分布。The adjustable beam parameters include the irradiation wavelength of each beam, the number of halo rings, the number of circular spots on each halo, the radius of each circular spot, the irradiation position of the beam, and the irradiation intensity. The light beam irradiation positions include various halo radii. By adjusting the adjustable beam parameters, the position and intensity of heat generation in the light-to-heat conversion object are controlled, which affects the distribution of heat, thereby changing the temperature distribution.
发射多光束并垂直照射在光热转换对象的表面后产生热量，当产热和散热达到平衡后，温度分布将稳定不变。稳定后的温度分布将有三种情况。若光热转换对象底部温度比侧边低，则进一步地减少所述各个光环半径，使得各多光束往靠近光热转换对象中心轴方向调节以改变所述光束照射位置；若光热转换对象底部温度比侧边高，则进一步地增大所述各个光环半径，使得各多光束往远离光热转换对象中心轴方向调节以改变所述光束照射位置；若光热转换对象底部温度与侧边近似，则无需再调节所述光束照射位置。Multiple beams are emitted and irradiated vertically on the surface of the light-to-heat conversion object to generate heat. When the heat generation and heat dissipation are balanced, the temperature distribution will be stable. The stabilized temperature distribution will have three situations. If the temperature at the bottom of the light-to-heat conversion object is lower than that at the side, then further reduce the radius of each halo, so that each multi-beam is adjusted toward the central axis of the light-to-heat conversion object to change the irradiation position of the light beam; if the bottom of the light-to-heat conversion object If the temperature is higher than that of the side, further increase the radius of each halo, so that each multi-beam is adjusted away from the central axis of the photothermal conversion object to change the irradiation position of the light beam; if the temperature of the bottom of the photothermal conversion object is similar to that of the side , then there is no need to adjust the beam irradiation position.
进一步地，当光热转换对象边缘温度低于48℃时，可增大所述照射强度以提高温度。当组织边缘温度高于55℃时，可减小所述照射强度以降低温度。Further, when the edge temperature of the light-to-heat conversion object is lower than 48° C., the irradiation intensity can be increased to increase the temperature. When the tissue edge temperature is higher than 55°C, the irradiation intensity can be reduced to lower the temperature.
以下以利用光热效应的光热治疗为例对上述改善光热效应温度分布的方法进行具体的说明。请结合参阅图2与图3，包括健康组织1和被所述健康组织1包裹的肿瘤2，多个光束3沿图2的箭头方向投射至所述肿瘤2顶部。The above-mentioned method for improving the temperature distribution of the photothermal effect will be specifically described below by taking the photothermal therapy utilizing the photothermal effect as an example. Please refer to FIG. 2 and FIG. 3 in conjunction, which includes
实施例1Example 1
实施例1中，作为光热转换对象的肿瘤2半径和厚度皆为2mm，并注入半径为20nm的金纳米球作为光热转换的材料，在肿瘤内的体积分数为
在步骤S10中，将所述初始照射波长设为对应金纳米球的共振波峰532nm，所述初始照射强度为15W/cm2，所述初始光环形状的环束为2且内圈半径R1为1mm、外圈半径R2为1.5mm，每圈上的光束数量为八个，光束半径设为在光热转换对象上投射所得的初始圆光斑半径r为0.15mm。In step S10, the initial irradiation wavelength is set to correspond to the resonance peak of gold nanospheres at 532nm, the initial irradiation intensity is 15W/cm2 , the ring beam of the initial halo shape is 2 and the inner radius R1 is 1mm , The radius R2 of the outer circle is 1.5mm, the number of beams on each circle is eight, and the radius of the beams is set to be 0.15mm for the initial circular spot radius r projected on the light-to-heat conversion object.
请参阅图5，步骤S20中，检测温度分布，结果发现等温线靠近所述底部C点，说明所述肿瘤2的顶部边缘的温度与所述肿瘤的底部中心温度的相差变小，即温度分布相对于正常激光照射的情况有明显改善。Please refer to FIG. 5, in step S20, the temperature distribution is detected, and it is found that the isotherm is close to the bottom point C, indicating that the difference between the temperature of the top edge of the
请参阅图6，执行步骤S30，调整所述光束照射位置，使得内圈半径R1变为0.4mm、外圈半径R2变为1mm后，所述肿瘤2的顶部边缘B点的温度与底部C点的温度相同，说明温度分布得到了进一步改善。Please refer to FIG. 6 , step S30 is performed to adjust the irradiation position of the light beam so that after the radius R1 of the inner circle becomes 0.4 mm and the radius R2 of the outer circle becomes 1 mm, the temperature at point B on the top edge of the
进一步将图4与图6进行比对，多光束环形照射模式下温度出现下降趋势，因此请参阅图7，将所述照射强度调整为30W/cm2以确保光热治疗所需要的温度。Further comparing Figure 4 with Figure 6, the temperature tends to decrease in the multi-beam ring irradiation mode, so please refer to Figure 7, and adjust the irradiation intensity to 30W/cm2 to ensure the temperature required for photothermal therapy.
实施例2Example 2
本发明实施例2与实施例1基本相同，区别仅在于所述肿瘤2的尺寸不同，具体表现在，实施例2中所述肿瘤2半径为2mm，厚度减小为1mm。请参阅图8，采用现有技术中常用的激光照射模式时，所述肿瘤2的顶部被垂直入射的激光光束3全覆盖。此时，所述肿瘤2的顶部边缘B点的温度低于所述肿瘤2的底部中心C点的温度，温度分布非常不均匀。采用本发明改善光热效应温度分布的方法，并依次执行上述步骤S10到步骤S30。Example 2 of the present invention is basically the same as Example 1, except that the size of the
在步骤S10中，将所述初始照射波长设为对应金纳米球的共振波峰532nm，所述初始照射强度为15W/cm2，所述初始光环形状的环束为2且内圈半径R1为1mm、外圈半径R2为1.5mm，每圈上的光束数量为八个，光束半径设为在光热转换对象上投射所得的初始圆光斑半径r为0.15mm。In step S10, the initial irradiation wavelength is set to correspond to the resonance peak of gold nanospheres at 532nm, the initial irradiation intensity is 15W/cm2 , the ring beam of the initial halo shape is 2 and the inner radius R1 is 1mm , The radius R2 of the outer circle is 1.5mm, the number of beams on each circle is eight, and the radius of the beams is set to be 0.15mm for the initial circular spot radius r projected on the light-to-heat conversion object.
请参阅图9，步骤S20中，检测温度分布，结果发现所述肿瘤2的顶部边缘B点温度仍然低于所述肿瘤2的底部中心C点温度。Please refer to FIG. 9 , in step S20 , the temperature distribution is detected, and it is found that the temperature at point B at the top edge of the
请参阅图10，执行步骤S30，调整所述光束照射位置，使得内圈半径R1变为1.1mm、外圈半径R2变为1.7mm后，所述顶部边缘B点的温度与所述底部中心C点的温度相同，说明温度分布得到了进一步改善。Please refer to FIG. 10 , step S30 is executed to adjust the irradiation position of the beam so that after the radius R1 of the inner circle becomes 1.1 mm and the radius R2 of the outer circle becomes 1.7 mm, the temperature at point B on the top edge is the same as that at the center C of the bottom. The temperature of the dots is the same, indicating that the temperature distribution has been further improved.
进一步将图8与图10进行比对，多光束环形照射模式下温度出现下降趋势，因此请参阅图11将进一步将所述照射强度调整为30W/cm2以达到光热治疗所需要的温度。Further comparing Figure 8 with Figure 10, the temperature tends to decrease in the multi-beam ring irradiation mode, so please refer to Figure 11 to further adjust the irradiation intensity to 30W/cm2 to reach the temperature required for photothermal therapy.
此外当所述肿瘤2的半径和厚度、所述光束初始照射波长、所述初始照射强度、所述初始光束数、所述初始光环排列形状、所述初始光束半径以及所述初始光束照射位置不一样时，多光束环形光的最佳照射位置是不一样的。对这些参数进行预设后再调节光照区域的位置，直到所述肿瘤2的顶部边缘和底部中心温度相同，从而获得最佳光束照射位置。In addition, when the radius and thickness of the
与现有技术相比较，本发明改善光热效应温度分布的方法通过改变光照形状来调控温度分布，公开了一种新的光照模式来改善光热效应温度分布的效果。本发明器件可控性强，可以根据实际需要调整光束形成的圆光斑的半径、光束形成的圆光斑的圈数、每圈圆光斑的数量、光束照射位置和光照强度等改变温度分布和温度大小。Compared with the prior art, the method for improving the temperature distribution of the photothermal effect in the present invention regulates the temperature distribution by changing the shape of the illumination, and discloses a new illumination mode to improve the effect of the temperature distribution of the photothermal effect. The device of the present invention has strong controllability, and can adjust the radius of the circular spot formed by the beam, the number of circles of the circular spot formed by the beam, the number of circular spots per circle, the irradiation position of the beam and the intensity of light, etc. to change the temperature distribution and temperature according to actual needs .
以上所述实施例仅表达了本发明的几种实施方式，其描述较为具体和详细，但并不能因此而理解为对发明专利范围的限制。应当指出的是，对于本领域的普通技术人员来说，在不脱离本发明构思的前提下，还可以做出若干变形和改进，这些都属于本发明的保护范围。The above-mentioned embodiments only express several implementation modes of the present invention, and the descriptions thereof are relatively specific and detailed, but should not be construed as limiting the patent scope of the invention. It should be pointed out that those skilled in the art can make several modifications and improvements without departing from the concept of the present invention, and these all belong to the protection scope of the present invention.
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