CN113171060A - An OCT imaging probe, sublingual microcirculation imaging device and system - Google Patents

Abstract

Translated fromChinese

本申请公开了一种OCT成像探头、舌下微循环成像装置及系统，其中该姿OCT成像探头包括：探头外壳、第一透镜组件、第一反射镜和MEMS扫描镜；第一透镜组件设置在探头外壳内；第一反射镜设置于探头外壳内，且位于第一透镜组件的折射光路上；MEMS扫描镜设置于探头外壳的输出端，且位于第一反射镜的反射光路上。解决了现有技术中的光学扫描镜体积大、成本高，且多为散装，导致OCT成像技术无法利用在舌下微循环成像中的技术问题。

The present application discloses an OCT imaging probe, a sublingual microcirculation imaging device and a system, wherein the posture OCT imaging probe includes: a probe housing, a first lens assembly, a first reflecting mirror and a MEMS scanning mirror; the first lens assembly is arranged on inside the probe housing; the first reflection mirror is arranged in the probe housing and is located on the refraction light path of the first lens assembly; the MEMS scanning mirror is arranged at the output end of the probe housing and is located on the reflected light path of the first reflection mirror. The optical scanning mirror in the prior art is large in size, high in cost, and mostly in bulk, which results in that the OCT imaging technology cannot be used in the imaging of sublingual microcirculation.

Description

OCT imaging probe, sublingual microcirculation imaging device and system

Technical Field

The application relates to the technical field of medical imaging, in particular to an OCT imaging probe, a sublingual microcirculation imaging device and a system.

Background

The microcirculation of the human body refers to the blood circulation among capillaries, is a basic unit in the blood circulation and can deliver nutrients to human tissues. The physiological structure and blood flow of the microcirculation reflect the physiological condition of human organs, so that the microcirculation of the human body is imaged, and whether the microcirculation is abnormal or not can be monitored, thereby assisting medical diagnosis, treatment and the like.

Optical Coherence Tomography (OCT) is a tomographic method, which performs tomographic imaging on the internal structure of a tissue by scanning, has the advantages of non-contact, no damage, high resolution, fast imaging, and the like, and has been widely used in many fields such as biomedical imaging. However, the conventional optical scanning mirror is large in size, high in cost and mostly bulk, so that the OCT imaging technology cannot be used in sublingual microcirculation imaging.

Disclosure of Invention

In view of this, the present application provides an OCT imaging probe, a sublingual microcirculation imaging device and a system, which solve the technical problem in the prior art that the OCT imaging technology cannot be used in sublingual microcirculation imaging due to the fact that an optical scanning mirror is large in size, high in cost and mostly in bulk.

The present application provides in a first aspect an OCT imaging probe comprising: the MEMS scanning device comprises a probe shell, a first lens assembly, a first reflecting mirror and an MEMS scanning mirror;

the first lens assembly is disposed within the probe housing;

the first reflector is arranged in the probe shell and is positioned on a refraction light path of the first lens component;

the MEMS scanning mirror is arranged at the output end of the probe shell and is positioned on a reflection light path of the first reflecting mirror.

Preferably, the MEMS scanning mirror is rotatably disposed at the output of the probe housing.

Preferably, the first lens assembly comprises: a first lens and a second lens;

the first lens and the second lens are both convex lenses, and the first lens and the second lens are arranged in the probe shell at intervals.

A second aspect of the application provides a sublingual microcirculation imaging device, comprising: a swept optical source, a beam shaping assembly, a reference arm, a data processor and any of the OCT imaging probes of the first aspect;

the first output end of the swept frequency light source is connected with the beam forming assembly and is used for outputting a swept frequency light beam to the beam forming assembly;

the first output end of the beam shaping assembly is respectively connected with the reference arm and the OCT imaging probe and is used for outputting the swept beam to the reference arm and the OCT imaging probe;

the OCT imaging probe is used for outputting the swept beam to sublingual tissue to be detected;

the beam forming assembly is further used for receiving reference light output by the reference arm based on the swept-frequency beam and test light output by the OCT imaging probe after the sublingual tissue is irradiated by the OCT imaging probe, and converging and interfering the reference light and the test light to obtain an interference signal;

the data processor is connected with the second output end of the swept-frequency light source and the second output end of the beam shaping assembly and is used for obtaining the OCT image of the sublingual tissue according to the interference signal.

Preferably, the method further comprises the following steps: a balance detector;

the input end of the balance detector is connected with the second output end of the beam shaping assembly, and the output end of the balance detector is connected with the data processor and used for converting the interference signal into an electric signal and outputting the electric signal to the data processor.

Preferably, the data processor is coupled to the MEMS scanning mirror for providing a drive signal to the MEMS scanning mirror.

Preferably, the beam shaping component is a fibre optic coupler.

Preferably, the reference arm comprises: a second lens assembly and a second mirror;

the second reflecting mirror is vertically arranged on a refraction light path of the second lens component.

Preferably, the second lens assembly comprises: a third lens and a fourth lens;

the third lens and the fourth lens are both convex lenses, and the third lens and the fourth lens are arranged at intervals.

A third aspect of the application provides a sublingual microcirculation imaging system, comprising: a display terminal and any one of the sublingual microcirculation imaging device of the second aspect;

the display terminal is electrically connected with the sublingual microcirculation imaging device.

According to the technical scheme, the method has the following advantages:

the application provides an OCT imaging probe, includes: the MEMS scanning device comprises a probe shell, a first lens assembly, a first reflecting mirror and an MEMS scanning mirror; the first lens assembly is arranged in the probe shell; the first reflector is arranged in the probe shell and is positioned on a refraction light path of the first lens component; the MEMS scanning mirror is arranged at the output end of the probe shell and is positioned on a reflection light path of the first reflecting mirror. The OCT imaging probe in the application utilizes the MEMS scanning mirror to control the light beam, thereby realizing the scanning imaging of the sublingual tissue. Compared with the defects of large volume, high cost and the like of the traditional scanning galvanometer, the MEMS scanning galvanometer has the advantages of small size, low cost, high scanning frequency, high response speed and the like, so that the size of the OCT imaging probe is small enough, and sublingual microcirculation is conveniently scanned and imaged, and the technical problem that the OCT imaging technology cannot be utilized in sublingual microcirculation imaging due to the fact that optical scanning galvanometers in the prior art are large in volume, high in cost and mostly in bulk is solved.

Drawings

In order to more clearly illustrate the technical solutions in the embodiments of the present application, the drawings needed to be used in the description of the embodiments are briefly introduced below, and it is obvious that the drawings in the following description are only some embodiments of the present application, and it is obvious for those skilled in the art to obtain other drawings based on these drawings without inventive exercise.

Fig. 1 is a schematic structural diagram of an OCT imaging probe according to an embodiment of the present disclosure;

FIG. 2 is a schematic diagram of a sublingual microcirculation imaging device according to an embodiment of the present application;

FIG. 3 is a schematic diagram of a sublingual microcirculation imaging system according to an embodiment of the present application;

wherein the reference numbers are as follows:

1. a probe housing; 2. a first lens; 3. a second lens; 4. a first reflector; 5. a MEMS scanning mirror; 6. sweeping a light source; 7. a beam shaping component; 8. a data processor; 9. a third lens; 10. a fourth lens; 11. a balance detector; 12. (ii) a A second mirror.

Detailed Description

The embodiment of the application provides an OCT imaging probe, sublingual microcirculation imaging device and system, has solved that the optical scanning mirror among the prior art is bulky, with high costs, and mostly is in bulk, leads to OCT imaging technique can't utilize the technical problem in sublingual microcirculation imaging.

The technical solutions of the embodiments of the present application will be described clearly and completely with reference to the accompanying drawings, and it is obvious that the described embodiments are some, but not all, of the embodiments of the present application. All other embodiments obtained by a person of ordinary skill in the art based on the embodiments in the present application without any creative effort belong to the protection scope of the embodiments in the present application.

In the description of the embodiments of the present application, it should be noted that the terms "center", "upper", "lower", "left", "right", "vertical", "horizontal", "inner", "outer", and the like indicate orientations or positional relationships based on the orientations or positional relationships shown in the drawings, and are only for convenience in describing the embodiments of the present application and simplifying the description, but do not indicate or imply that the referred devices or elements must have specific orientations, be configured in specific orientations, and operate, and thus, should not be construed as limiting the embodiments of the present application. Furthermore, the terms "first," "second," and "third" are used for descriptive purposes only and are not to be construed as indicating or implying relative importance.

In the description of the embodiments of the present application, it should be noted that the terms "mounted," "connected," and "connected" are used broadly and are defined as, for example, a fixed connection, an exchangeable connection, an integrated connection, a mechanical connection, an electrical connection, a direct connection, an indirect connection through an intermediate medium, and a communication between two elements, unless otherwise explicitly stated or limited. Specific meanings of the above terms in the embodiments of the present application can be understood in specific cases by those of ordinary skill in the art.

The present application provides a first embodiment of a sublingual microcirculation imaging system based on OCT imaging technology, please refer to fig. 1 specifically.

This embodiment an OCT imaging probe, comprising: the probe comprises a probe shell 1, a first lens 2 assembly, a first reflecting mirror 4 and anMEMS scanning mirror 5; the first lens 2 assembly is arranged in the probe shell 1; the first reflector 4 is arranged in the probe shell 1 and is positioned on a refraction light path of the first lens 2 component; theMEMS scanning mirror 5 is arranged at the output end of the probe shell 1 and is positioned on the reflection light path of the first reflecting mirror 4.

In this embodiment, after the swept-frequency beam enters the OCT imaging probe, the first lens 2 component refracts the swept-frequency beam, and since the first reflecting mirror 4 is located on the refraction light path of the first lens 2 component, the refracted swept-frequency beam reaches the first reflecting mirror 4, and since theMEMS scanning mirror 5 is located on the reflection light path of the first reflecting mirror 4, the swept-frequency beam reflected by the first reflecting mirror 4 reaches theMEMS scanning mirror 5, and is then reflected by theMEMS scanning mirror 5 and output to the imaging probe, and reaches the sublingual tissue surface.

It should be noted that, in order to perform relatively comprehensive imaging on the sublingual tissue, the inclination angle of theMEMS scanning mirror 5 in this embodiment is adjustable, that is, theMEMS scanning mirror 5 is rotatably disposed at the output end of the probe housing 1, and the sweep beam is controlled by the inclination of the mirror surface of theMEMS scanning mirror 5, so as to implement one-dimensional or two-dimensional scanning imaging on the sublingual tissue.

Specifically, in one embodiment, the mirror tilt angle of theMEMS scanning mirror 5 is adjusted by a drive. Therefore, the OCT imaging probe in this embodiment further includes: a drive member; the driving piece is connected with theMEMS scanning mirror 5 and is used for controlling the inclination angle of theMEMS scanning mirror 5. It is understood that the driving member may be a structural member having a driving function, such as a motor, and this is not particularly limited in this embodiment.

It is understood that in another embodiment, the inclination angle of the mirror surface of theMEMS scanning mirror 5 is adjusted by an electrostatic driving method, and polarization is realized by electrostatic interaction between charged conductors on theMEMS scanning mirror 5.

For the scanning mode of theMEMS scanning mirror 5 during imaging, a point-to-point beam scanning mode is adopted, the driving voltage of the point-to-point beam scanning mode corresponds to the scanning angle in a one-to-one mode, and deflection at any angle is achieved by controlling the voltage, so that the sweep beam irradiates the surface of the tissue at any angle, and the depth information of the sublingual tissue is imaged.

Specifically, the first lens 2 assembly in the present embodiment includes: a first lens 2 and a second lens 3; the first lens 2 and the second lens 3 are both convex lenses, and the first lens 2 and the second lens 3 are arranged in the probe shell 1 at intervals.

In the embodiment, the OCT imaging probe controls the sweep beam by using theMEMS scanning mirror 5, thereby realizing scanning imaging of the sublingual tissue. Compared with the defects of large size, high cost and the like of the traditional scanning galvanometer, theMEMS scanning galvanometer 5 has the advantages of small size, low cost, high scanning frequency, high response speed and the like, so that the size of the OCT imaging probe is small enough, and sublingual microcirculation is conveniently scanned and imaged, and the technical problem that the OCT imaging technology cannot be utilized in sublingual microcirculation imaging due to the fact that optical scanning galvanometers in the prior art are large in size, high in cost and mostly in bulk is solved.

The above is an example of an OCT imaging probe provided in this application, and the following is an example of a sublingual microcirculation imaging device provided in this application.

Referring to fig. 2, the sublingual microcirculation imaging device in the present embodiment includes: sweptsource 6,beam shaping assembly 7, reference arm,data processor 8 and OCT imaging probe as in any of the above embodiments; the first output end of the sweeplight source 6 is connected with thebeam forming assembly 7 and used for outputting a sweep light beam to thebeam forming assembly 7; the first output end of thebeam forming component 7 is respectively connected with the reference arm and the OCT imaging probe and is used for outputting the sweep beam to the reference arm and the OCT imaging probe; the OCT imaging probe is used for outputting the sweep frequency light beam to sublingual tissue to be detected; the beam forming assembly is also used for receiving reference light output by the reference arm based on the sweep frequency beam and test light output by the OCT imaging probe after the sublingual tissue is irradiated by the OCT imaging probe, and converging and interfering the reference light and the test light to obtain an interference signal; and thedata processor 8 is connected with the second output end of the swept-frequency light source 6 and the second output end of thebeam shaping assembly 7 and is used for obtaining the OCT image of the sublingual tissue according to the interference signal.

Interference spectra of the reference arm and the OCT imaging probe and backscattered light intensity information of different depths of the sample are in a relationship of a pair of Fourier transform pairs, so that an OCT image of the sublingual tissue can be obtained after inverse Fourier transform is carried out on the interference spectrum information of the reference arm and the OCT imaging probe.

It can be understood that, in order to reduce the light beam loss, suppress noise, and improve the imaging signal-to-noise ratio, the sublingual microcirculation imaging device in the embodiment further includes: abalance detector 11; the input end of thebalance detector 11 is connected with the second output end of thebeam shaping assembly 7, and the output end is connected with thedata processor 8, and is used for converting the interference signal into an electric signal and outputting the electric signal to the data processor.

Thedata processor 8 is electrically connected with the sweeplight source 6, thebalance detector 11 and theMEMS scanning mirror 5, the sweeplight source 6 outputs a clock signal to thedata processor 8, thedata processor 8 is triggered to control theMEMS scanning mirror 5 to scan and thebalance detector 11 to synchronously acquire interference signals, and the acquired interference signals are subjected to Fourier analysis by thedata processor 8 to calculate the intensity information of tissue depth, so that an OCT image is calculated.

Specifically, adata processor 8 is connected to theMEMS scanning mirror 5 for providing a drive signal to theMEMS scanning mirror 5. It is also possible that thedata processor 8 is connected to the drive member for providing the drive signal to the drive member. The rotation and inclination angle of theMEMS scanning mirror 5 are controlled by the driving signal.

Wherein thebeam shaping component 7 is a fiber coupler. It is understood that thebeam shaping component 7 may be other components, and those skilled in the art can select them as needed, and will not be described herein.

Further, the reference arm comprises: a second lens 3 assembly and asecond mirror 12; the second reflectingmirror 12 is vertically arranged on the refraction light path of the second lens 3 component.

Specifically, the second lens 3 assembly includes: a third lens 9 and afourth lens 10; the third lens 9 and thefourth lens 10 are both convex lenses, and the third lens 9 and thefourth lens 10 are arranged at intervals.

In the sublingual microcirculation imaging device in the embodiment, a sweep light beam emitted by a sweeplight source 6 is divided into two beams of light after passing through an optical fiber coupler, the two beams of light respectively enter a reference arm and an OCT imaging probe, the sweep light beam irradiates asecond reflector 12 through a third lens 9 and afourth lens 10 of the reference arm, and the sweep light beam is reflected by thesecond reflector 12 to form reference light; the scanning beam is focused by a first lens 2 and a second lens 3 of the OCT imaging probe, then irradiates a first reflector 4, is reflected to anMEMS scanning mirror 5 by the first reflector 4, and is reflected to the surface of a tissue by theMEMS scanning mirror 5, theMEMS scanning mirror 5 is controlled by an output processor, the mirror surface is driven by a motor to incline and deflect to control the beam, so that the transverse one-dimensional or two-dimensional scanning of the tissue is realized, the scanning beam returns to theMEMS scanning mirror 5 after being subjected to tissue diffuse reflection, and then forms test light by the first reflector 4, the second lens 3 and the first lens 2. The reference light and the test light are converged in the optical fiber coupler and interfere with each other, an interference signal is detected by thebalance detector 11 and converted into an electric signal, and the electric signal is input to thedata processor 8 for Fourier analysis and the OCT image is calculated.

The sublingual microcirculation imaging device in the embodiment has the advantages of small size, low cost, high scanning frequency and high response speed, and is convenient for scanning and imaging sublingual microcirculation, so that the technical problem that an OCT imaging technology cannot be utilized in sublingual microcirculation imaging due to the fact that an optical scanning mirror in the prior art is large in size, high in cost and mostly in bulk is solved.

The above is an embodiment of a sublingual microcirculation imaging device provided in the present application, and the following is an embodiment of a sublingual microcirculation imaging system provided in the present application.

Referring to fig. 3, the sublingual microcirculation imaging system of the present embodiment includes: adisplay terminal 101 and a sublingualmicrocirculation imaging device 102 as in any one of the above embodiments; thedisplay terminal 101 is electrically connected to the sublingualmicrocirculation imaging device 102.

It is understood that thedisplay terminal 101 in this embodiment may be a computer or a dedicated display, which is not limited and described herein.

The sublingual microcirculation imaging system in the embodiment is convenient for scanning and imaging sublingual microcirculation, so that the technical problem that an OCT imaging technology cannot be utilized in sublingual microcirculation imaging due to the fact that an optical scanning mirror in the prior art is large in size, high in cost and mostly in bulk is solved.

The above embodiments are only used for illustrating the technical solutions of the present application, and not for limiting the same; although the present application has been described in detail with reference to the foregoing embodiments, it should be understood by those of ordinary skill in the art that: the technical solutions described in the foregoing embodiments may still be modified, or some technical features may be equivalently replaced; and such modifications or substitutions do not depart from the spirit and scope of the corresponding technical solutions in the embodiments of the present application.

Claims (10)

Translated fromChinese

1.一种OCT成像探头，其特征在于，包括：探头外壳、第一透镜组件、第一反射镜和MEMS扫描镜；1. an OCT imaging probe, is characterized in that, comprises: probe housing, the first lens assembly, the first reflection mirror and the MEMS scanning mirror;所述第一透镜组件设置在所述探头外壳内；the first lens assembly is arranged in the probe housing;所述第一反射镜设置于所述探头外壳内，且位于所述第一透镜组件的折射光路上；The first reflection mirror is arranged in the probe housing and is located on the refraction light path of the first lens assembly;所述MEMS扫描镜设置于所述探头外壳的输出端，且位于所述第一反射镜的反射光路上。The MEMS scanning mirror is disposed at the output end of the probe housing, and is located on the reflected light path of the first reflecting mirror.2.根据权利要求1所述的OCT成像探头，其特征在于，所述MEMS扫描镜可转动地设置于所述探头外壳的输出端。2 . The OCT imaging probe according to claim 1 , wherein the MEMS scanning mirror is rotatably disposed at the output end of the probe housing. 3 .3.根据权利要求1所述的OCT成像探头，其特征在于，所述第一透镜组件包括：第一透镜和第二透镜；3. The OCT imaging probe according to claim 1, wherein the first lens assembly comprises: a first lens and a second lens;所述第一透镜和所述第二透镜均为凸透镜，且所述第一透镜和所述第二透镜间隔设置于所述探头外壳内。The first lens and the second lens are both convex lenses, and the first lens and the second lens are arranged in the probe housing at intervals.4.一种舌下微循环成像装置，其特征在于，包括：扫频光源、光束成形组件、参考臂、数据处理器和如权利要求1至3中任一项所述的OCT成像探头；所述扫频光源的第一输出端连接所述光束成形组件，用于输出扫频光束至所述光束成形组件；4. A sublingual microcirculation imaging device, comprising: a frequency swept light source, a beam shaping assembly, a reference arm, a data processor, and the OCT imaging probe according to any one of claims 1 to 3; the The first output end of the swept frequency light source is connected to the beam shaping component, and is used for outputting the swept frequency beam to the beam shaping component;所述光束成形组件的第一输出端分别连接所述参考臂和所述OCT成像探头，用于输出所述扫频光束至所述参考臂和所述OCT成像探头；The first output end of the beam shaping assembly is respectively connected to the reference arm and the OCT imaging probe, and is used for outputting the frequency sweeping beam to the reference arm and the OCT imaging probe;所述OCT成像探头，用于将所述扫频光束输出至待测的舌下组织；The OCT imaging probe is used for outputting the frequency sweep beam to the sublingual tissue to be measured;所述光束成形组件，还用于接收所述参考臂基于所述扫频光束输出的参考光和所述OCT成像探头照射所述舌下组织后输出的测试光，并将所述参考光和所述测试光进行汇合、干涉得到干涉信号；The beam shaping assembly is further configured to receive the reference light output by the reference arm based on the frequency swept beam and the test light output after the OCT imaging probe irradiates the sublingual tissue, and combine the reference light with the test light. The test light is combined and interfered to obtain an interference signal;所述数据处理器连接所述扫频光源的第二输出端、所述光束成形组件的第二输出端，用于根据所述干涉信号得到所述舌下组织的OCT图像。The data processor is connected to the second output end of the frequency swept light source and the second output end of the beam shaping component, and is used for obtaining the OCT image of the sublingual tissue according to the interference signal.5.根据权利要求4所述的舌下微循环成像装置，其特征在于，还包括：平衡探测器；5. The sublingual microcirculation imaging device according to claim 4, further comprising: a balance detector;所述平衡探测器的输入端连接所述光束成形组件的第二输出端，输出端连接所述数据处理器，用于将所述干涉信号转换为电信号，并将所述电信号输出至所述数据处理器。The input end of the balanced detector is connected to the second output end of the beam shaping component, and the output end is connected to the data processor for converting the interference signal into an electrical signal and outputting the electrical signal to the data processor. the data processor.6.根据权利要求4所述的舌下微循环成像装置，其特征在于，所述数据处理器和所述MEMS扫描镜连接，用于为所述MEMS扫描镜提供驱动信号。6 . The sublingual microcirculation imaging device according to claim 4 , wherein the data processor is connected to the MEMS scanning mirror, and is used to provide a driving signal for the MEMS scanning mirror. 7 .7.根据权利要求4所述的舌下微循环成像装置，其特征在于，所述光束成形组件为光纤耦合器。7 . The sublingual microcirculation imaging device according to claim 4 , wherein the beam shaping component is an optical fiber coupler. 8 .8.根据权利要求4所述的舌下微循环成像装置，其特征在于，所述参考臂包括：第二透镜组件和第二反射镜；8. The sublingual microcirculation imaging device according to claim 4, wherein the reference arm comprises: a second lens assembly and a second mirror;所述第二反射镜竖直设置于所述第二透镜组件的折射光路上。The second reflecting mirror is vertically arranged on the refracted light path of the second lens assembly.9.根据权利要求8所述的舌下微循环成像装置，其特征在于，所述第二透镜组件包括：第三透镜和第四透镜；9. The sublingual microcirculation imaging device according to claim 8, wherein the second lens assembly comprises: a third lens and a fourth lens;所述第三透镜和所述第四透镜均为凸透镜，且所述第三透镜和所述第四透镜间隔设置。The third lens and the fourth lens are both convex lenses, and the third lens and the fourth lens are arranged at intervals.10.一种舌下微循环成像系统，其特征在于，包括：显示终端和如权利要求4至9中任一项所述的舌下微循环成像装置；10. A sublingual microcirculation imaging system, comprising: a display terminal and the sublingual microcirculation imaging device according to any one of claims 4 to 9;所述显示终端和所述舌下微循环成像装置电连接。The display terminal is electrically connected to the sublingual microcirculation imaging device.

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