CN113081079A - Blood bridge limiter - Google Patents

Abstract

The utility model provides a blood bridge stopper for two individuals carry on spacingly and establish blood bridge in to antithetical couplet intergrowth model, blood bridge stopper includes: two supports, blood vessel intubation tube connector pedestal, blood vessel intubation tube connector and two restraint rings. The neck parts of two individuals in the conjuncted symbiotic model are fixed, so that the traditional conjuncted symbiotic operation can be avoided, the mutual attack among the individuals is limited, the success rate of the conjuncted symbiotic model construction is improved, and the time required by molding is shortened.

Description

Blood bridge limiter

Technical Field

The utility model relates to a biological assay field especially relates to a blood bridge stopper.

Background

Conjunctive symbiosis is used to pair different animal individuals to study biological systems or circulatory related problems, and two bodies have a common vascular system after being combined through surgical conjunctions, and the result is similar to that of human conjunctive twins. The experimental symbiosis surgical technique of the conjunct animals is established by the french physiologist Paul Bert in the 60 s of the 19 th century using white albino rats.

Currently, mice are preferentially used in the symbiotic model of conjunctions, but the associated surgical procedures still follow the method of Paul Bert: skin incisions are made along the adjacent flanks of two individuals and the adjacent flaps are sutured together, the peritoneum of the sutured site forming a common peritoneal cavity, and the vessels of the two individuals are joined to form an anastomosis due to revascularization of the injured tissue. By using syngeneic individuals, conjunctive symbiotic tissue rejection can be reduced and survival rates can be improved.

The success rate of constructing the conjunctive symbiotic model and the time required for molding can be influenced by individual infection caused by the operation process and operation, tissue rejection reaction between postoperative individuals, mutual attack and detachment behaviors. In addition, the use of the immune stress and inflammatory response in the body background of the conjunctive symbiotic surgery model can limit the research related to the immune stress and inflammatory response.

Disclosure of Invention

Technical problem to be solved

The present disclosure provides a blood bridge stopper to solve the above-mentioned technical problems.

(II) technical scheme

According to an aspect of the present disclosure, there is provided a blood bridge stopper for stopping two individuals in a symbiotic model of an associated body and establishing a blood bridge, the blood bridge stopper comprising:

the two support bodies are symmetrically arranged in parallel;

the blood vessel intubation connector base body is perpendicular to the two support bodies, and two ends of the blood vessel intubation connector base body are respectively connected with the two support bodies;

the blood vessel intubation connector is inserted on the blood vessel intubation connector base body and penetrates through the blood vessel intubation connector base body; the blood vessel intubation connector is used for connecting the carotid artery blood vessel and the jugular vein blood vessel between two individuals in the conjuncted symbiotic model in a cross way;

two ends of the restraining ring are respectively connected with two ends of the two supporting bodies, and the two restraining rings are symmetrically arranged at the two ends of the supporting bodies; the restraint ring and the support body are matched with clamp rings to clamp the neck of an individual in the conjuncted symbiotic model.

In some embodiments of the present disclosure, further comprising:

the blocking seat body is connected with the two support bodies, and the surface of the blocking seat body is perpendicular to the surface of the two support bodies;

the barrier body is connected with the blocking seat body; when two individuals in the conjunctive symbiotic model move and/or do not move, the heads of the two individuals are in contact with the edge of the obstacle body so as to limit mutual attack between the two individuals in the conjunctive symbiotic model.

In some embodiments of the present disclosure, the support body comprises:

the end parts of the two ends of the supporting seat body are respectively connected with one restraint ring;

the two constraint blocks are symmetrically arranged on the same side of the support base body and are fixedly connected with the support base body; the restraining blocks on the two supporting bodies are oppositely arranged.

In some embodiments of the present disclosure, the constraining block has a circular arc-shaped structure; two the two about piece that set up on two the supporter relatively with the restraint ring constitutes one end open-ended ring structure, just individual neck in the conjuncted intergrowth model of ring structure clamp.

In some embodiments of the present disclosure, the blocking seat body has a circular arc-shaped structure; the open ends of the blocking seat bodies are respectively connected with the two support bodies; the barrier body is tangent to the blocking seat body.

In some embodiments of the present disclosure, the surface of the obstacle is parallel to the surfaces of the two supporting bodies.

In some embodiments of the present disclosure, the barrier is a cylindrical structure.

In some embodiments of the present disclosure, the vessel intubation connector base and the two support bodies are in an i-shaped structure.

In some embodiments of the present disclosure, the blood vessel intubation connector base is disposed at a central line position of the two support bodies, and two ends of the support bodies are symmetrical to each other with respect to the blood vessel intubation connector base.

In some embodiments of the present disclosure, the two side walls of the supporting body are respectively provided with a buckle, and the restraining ring is fixedly connected to the supporting body through the buckles.

(III) advantageous effects

According to the technical scheme, the blood bridge limiter disclosed by the invention has at least one or one part of the following beneficial effects:

(1) the neck parts of two individuals in the conjuncted symbiotic model are fixed, and the blood vessel intubation connector is used for simultaneously connecting the carotid artery blood vessel of one individual in the conjuncted symbiotic model and the jugular vein blood vessel of the other individual in the conjuncted symbiotic model to form a blood vessel bridge, so that the success rate of constructing the conjuncted symbiotic model is improved, and the time required by molding is shortened.

(2) In the arrangement of the blocking seat body and the barrier body, the barrier body is arranged between the heads of the two individuals, so that the two individuals are prevented from being in direct contact, and the attack behavior between the individuals in conjuncted symbiosis is inhibited.

Drawings

Fig. 1 is a schematic top view of a blood bridge stopper according to an embodiment of the present disclosure.

Fig. 2 is a schematic bottom view of the blood bridge stopper according to the embodiment of the present disclosure.

Fig. 3 is a disassembled structure schematic diagram of fig. 1.

Fig. 4 is a disassembled structure schematic diagram of fig. 2.

[ description of main reference numerals in the drawings ] of the embodiments of the present disclosure

1-a barrier;

10-a barrier seat body;

11-a disorder;

2-a support;

20-a support base;

21-a constraint block;

3-buckling;

4-a vascular cannula connector;

40-a blood vessel intubation connector base;

41-blood vessel intubation joint;

5-a confinement ring;

Detailed Description

The utility model provides a blood bridge stopper for two individuals carry on spacingly and establish blood bridge in to antithetical couplet intergrowth model, blood bridge stopper includes: two supports, blood vessel intubation tube connector pedestal, blood vessel intubation tube connector and two restraint rings. The neck parts of two individuals in the conjuncted symbiotic model are fixed, and the blood vessel intubation connector is simultaneously connected with the carotid artery blood vessel of one individual in the conjuncted symbiotic model and the jugular vein blood vessel of the other individual in the conjuncted symbiotic model to form a blood vessel bridge, so that the success rate of constructing the conjuncted symbiotic model is improved, and the time required by molding is shortened.

For the purpose of promoting a better understanding of the objects, aspects and advantages of the present disclosure, reference is made to the following detailed description taken in conjunction with the accompanying drawings.

Certain embodiments of the present disclosure will now be described more fully hereinafter with reference to the accompanying drawings, in which some, but not all embodiments of the disclosure are shown. Indeed, various embodiments of the disclosure may be embodied in many different forms and should not be construed as limited to the embodiments set forth herein; rather, these embodiments are provided so that this disclosure will satisfy applicable legal requirements.

In a first exemplary embodiment of the present disclosure, a blood bridge stop is provided. Fig. 1 is a schematic top view of a blood bridge stopper according to an embodiment of the present disclosure. Fig. 2 is a schematic bottom view of the blood bridge stopper according to the embodiment of the present disclosure. Fig. 3 is a disassembled structure schematic diagram of fig. 1. Fig. 4 is a disassembled structure schematic diagram of fig. 2. As shown in fig. 1-4, the blood bridge stopper of the present disclosure includes: twosupport bodies 2, avessel intubation connector 4 and tworestriction rings 5. The twosupport bodies 2 are arranged in parallel and symmetrically. The vesselintubation tube connector 41base 20 is perpendicular to the twosupport bodies 2, and two ends of the vessel intubationtube connector base 40 are respectively connected to the twosupport bodies 2. The blood vessel intubationconnector seat body 40 and the twosupport bodies 2 are in an I-shaped structure. Two restraint rings 5 are symmetrically arranged at two ends of two supportingbodies 2, and eachrestraint ring 5 is connected with one end of each supportingbody 2 through abuckle 3. Therestraint ring 5 and thesupport body 2 are matched with necks of individuals in the hoop connected symbiotic model to limit the two individuals in the connected symbiotic model.

The blood vesselintubation connecting body 4 includes: a vessel intubation tubeconnector holder body 40 and a vesselintubation tube connector 41. The bloodvessel intubation connector 41 is inserted into the blood vesselintubation connector base 40 and passes through the blood vesselintubation connector base 40. Thevessel intubation connector 41 is connected with the carotid artery vessel of one individual in the conjuncted symbiotic model and the jugular vein vessel of another individual in the conjuncted symbiotic model at the same time to establish a blood bridge.

In an embodiment of the present disclosure, there is further provided abarrier 1 for limiting mutual attack between two individuals in a conjunctive symbiotic model, specifically including: abarrier seat 10 and abarrier 11. The blockingseat body 10 is connected with the twosupport bodies 2, and the surface of the blockingseat body 10 is perpendicular to the surfaces of the twosupport bodies 2. Thebarrier body 11 is connected with thebarrier seat body 10; when two individuals in the conjunctive symbiotic model move and/or do not move, the heads of the two individuals are in contact with the edge of theobstacle 11 so as to limit the mutual attack between the two individuals in the conjunctive symbiotic model.

The material of thebarrier 11 may be a flexible material such as silicone rubber, latex, etc. to avoid causing external injury to the individual. Thebarrier body 11 and the blockingseat body 10 can be connected by laser welding, and other processing technologies capable of realizing the fixed connection of thebarrier body 11 and the blockingseat body 10 can be selected and used, and are not expanded in detail here.

The cross-sectional shape of thebarrier 11 may be circular, oval, rectangular, square or any other special-shaped structure capable of limiting individual contact and providing space between individuals.

As for the specific shape of the blockingbase 10, a semicircular shape, an arc shape and an L shape can be selected.

As an embodiment, the blockingseat 10 is shown as a circular arc structure, and the two ends of the blockingseat 10 are connected to the two supportingbodies 2. Theobstacle body 11 and the blockingseat body 10 are tangent, and the surface of theobstacle body 11 is parallel to the surfaces of the two supportingbodies 2.

As an embodiment, as shown in the figure, the blockingseat 10 has an arc-shaped structure, and at this time, one end of the blockingseat 10 is connected to any one of thesupport body 2 or the blood vessel intubation-tube connector seat 40.

As an embodiment, the blockingseat 10 is an L-shaped structure, one end of the blockingseat 10 is connected to any one of the supportingbody 2 or the blood vessel intubation-tube connector seat 40, and the long side of the blockingseat 10 is connected to theobstacle 11.

In one embodiment of the present disclosure, the supportingbody 2 includes a supportingseat 20 and two constrainingblocks 21. The two supporting seat bodies are symmetrically arranged at the same side of the supportingseat body 20, and are fixedly connected with the supportingseat body 20 and are in a pi-shaped structure.

Regarding the connection between thesupport base 20 and theconfinement ring 5, the side walls of the two ends of thesupport base 20 are respectively provided with abuckle 3, and after the two ends of theconfinement ring 5 are inserted into thebuckles 3, the two ends are fixedly connected with thesupport body 2 by the wire saw principle or screw fastening.

In the specific embodiment, the constrainingblocks 21 on the two supportingbodies 2 are oppositely arranged. The two oppositely disposed restraining blocks 21 are not in contact and the two restraining blocks 21 are generally disposed at a distance. As a preferred embodiment, the constrainingring 5 is a semi-arc structure, and two ends of the constrainingring 5 are respectively matched with the two constrainingblocks 21 to form a circular ring structure with an opening.

In one embodiment of the present disclosure, the bloodvessel cannula connector 41 connects the blood vessel cannula model of the carotid artery of one experimental animal and the blood vessel cannula model of the jugular vein of another experimental animal at the same time. The vessel cannulation model of carotid artery and the vessel cannulation model of jugular vein of the experimental animals are prepared separately and are not described in detail. Pairs of isogenotypes were pre-labeled. When a conjuncted symbiotic experiment is required, the cannulas of the carotid artery blood vessels and the cannulas of the jugular vein blood vessels of two individuals are connected in a cross mode under the condition that a lateral ventral wound is not generated. For example, a cannula of a carotid artery vessel of one individual is connected to a cannula of a jugular vein vessel of another individual. The vasodilation pressure is generally higher than the venous pressure, so that the blood circulation is ensured to be communicated after the carotid artery blood vessel and the jugular vein blood vessel are in cross connection between two individuals.

So far, the embodiments of the present disclosure have been described in detail with reference to the accompanying drawings. It is to be noted that, in the attached drawings or in the description, the implementation modes not shown or described are all the modes known by the ordinary skilled person in the field of technology, and are not described in detail. Further, the above definitions of the various elements and methods are not limited to the various specific structures, shapes or arrangements of parts mentioned in the examples, which may be easily modified or substituted by those of ordinary skill in the art.

From the above description, those skilled in the art should have a clear understanding of the blood bridge stop of the present disclosure.

In summary, the present disclosure provides a blood bridge stopper for fixing the necks of two individuals in a conjunctive symbiotic model, and a bloodvessel cannula connector 41 is used to connect the carotid artery blood vessel of one individual in the conjunctive symbiotic model and the jugular vein blood vessel of another individual in the conjunctive symbiotic model at the same time to form a blood bridge, so as to improve the success rate of the conjunctive symbiotic model construction and shorten the time required for molding.

It should also be noted that directional terms, such as "upper", "lower", "front", "rear", "left", "right", and the like, used in the embodiments are only directions referring to the drawings, and are not intended to limit the scope of the present disclosure. Throughout the drawings, like elements are represented by like or similar reference numerals. Conventional structures or constructions will be omitted when they may obscure the understanding of the present disclosure.

And the shapes and sizes of the respective components in the drawings do not reflect actual sizes and proportions, but merely illustrate the contents of the embodiments of the present disclosure. Furthermore, in the claims, any reference signs placed between parentheses shall not be construed as limiting the claim.

Furthermore, the word "comprising" does not exclude the presence of elements or steps not listed in a claim. The word "a" or "an" preceding an element does not exclude the presence of a plurality of such elements.

The use of ordinal numbers such as "first," "second," "third," etc., in the specification and claims to modify a corresponding element does not by itself connote any ordinal number of the element or any ordering of one element from another or the order of manufacture, and the use of the ordinal numbers is only used to distinguish one element having a certain name from another element having a same name.

Similarly, it should be appreciated that in the foregoing description of exemplary embodiments of the disclosure, various features of the disclosure are sometimes grouped together in a single embodiment, figure, or description thereof for the purpose of streamlining the disclosure and aiding in the understanding of one or more of the various disclosed aspects. However, the disclosed method should not be interpreted as reflecting an intention that: that is, the claimed disclosure requires more features than are expressly recited in each claim. Rather, as the following claims reflect, disclosed aspects lie in less than all features of a single foregoing disclosed embodiment. Thus, the claims following the detailed description are hereby expressly incorporated into this detailed description, with each claim standing on its own as a separate embodiment of this disclosure.

The above-mentioned embodiments are intended to illustrate the objects, aspects and advantages of the present disclosure in further detail, and it should be understood that the above-mentioned embodiments are only illustrative of the present disclosure and are not intended to limit the present disclosure, and any modifications, equivalents, improvements and the like made within the spirit and principle of the present disclosure should be included in the scope of the present disclosure.

Claims (10)

Translated fromChinese

1.一种血桥限位器，用于对联体共生模型中两个个体进行限位并建立血桥，所述血桥限位器包括：1. A blood bridge limiter for limiting two individuals in a conjoined symbiosis model and establishing a blood bridge, the blood bridge limiter comprising:两个支撑体，平行对称设置；Two supports, arranged in parallel and symmetrically;血管插管连接头座体，所述血管插管连接头座体与两个所述支撑体相垂直设置，且血管插管连接头座体两端分别与两个所述支撑体连接；a blood vessel cannula connection head body, the blood vessel cannula connection head body is perpendicular to the two support bodies, and both ends of the blood vessel cannula connection head body are respectively connected with the two support bodies;血管插管连接头，插设在所述血管插管连接头座体上，且穿过所述血管插管连接头座体；所述血管插管连接头将所述联体共生模型中两个体间的颈动脉血管和颈静脉血管相互交叉连接；The vascular cannula connector is inserted on the vascular cannula connector base and passes through the vascular cannula connector base; the vascular cannula connector connects the two bodies in the conjoined symbiosis model The carotid arteries and jugular veins are cross-connected to each other;两个约束环，所述约束环两端分别与两个支撑体两端连接，且两个所述约束对称设置在所述支撑体两端；所述约束环与所述支撑体配合卡箍所述联体共生模型中个体的颈部。Two confinement rings, the two ends of the confinement rings are respectively connected with the two ends of the two support bodies, and the two restraints are symmetrically arranged at the two ends of the support bodies; the confinement rings and the support body cooperate with the clamps. The neck of an individual in the parametria model.2.根据权利要求1所述的血桥限位器，其中，还包括：2. The blood bridge limiter according to claim 1, wherein, further comprising:阻挡座体，阻挡座体与两个所述支撑体连接，且所述阻挡座体所在面与两个所述支撑体所在面相垂直；a blocking seat, the blocking seat is connected with the two supporting bodies, and the surface where the blocking seat is located is perpendicular to the surface where the two supporting bodies are located;障碍体，与所述阻挡座体连接；所述联体共生模型中两个个体运动和/或不运动时，两个所述个体的头部与所述障碍体缘边相接触，以限制所述联体共生模型中两个个体间相互攻击。The obstacle body is connected with the blocking seat body; in the conjoined symbiosis model, when two individuals move and/or do not move, the heads of the two individuals are in contact with the edge of the obstacle body, so as to limit all the obstacles. Two individuals attack each other in the parasymbiotic model.3.根据权利要求1所述的血桥限位器，其中，所述支撑体包括：3. The blood bridge stopper according to claim 1, wherein the support body comprises:支撑座体，所述支撑座体两端端部分别连接一个所述约束环；a support base, the two ends of the support base are respectively connected with one of the restraining rings;两个约束块，对称设置在所述支撑座体同侧，且与所述支撑座体固定连接；两个所述支撑体上的所述约束块相对设置。Two constraining blocks are symmetrically arranged on the same side of the support base and are fixedly connected with the support base; the constraining blocks on the two support bodies are arranged opposite to each other.4.根据权利要求3所述的血桥限位器，其中，所述约束块呈圆弧状结构；两个所述支撑体上相对设置的两个所述约束块与所述约束环构成一端开口的圆环结构，且所述圆环结构卡箍所述联体共生模型中个体的颈部。4 . The blood bridge limiter according to claim 3 , wherein the constraining block has an arc-shaped structure; the two constraining blocks disposed oppositely on the two support bodies and the constraining ring form one end. 5 . An open ring structure, and the ring structure clamps the neck of the individual in the conjoined symbiosis model.5.根据权利要求2所述的血桥限位器，其中，所述阻挡座体为圆弧状结构；所述阻挡座体的开口端分别与两个所述支撑体连接；所述障碍体与所述阻挡座体相切。5 . The blood bridge stopper according to claim 2 , wherein the blocking seat is an arc-shaped structure; the open ends of the blocking seat are respectively connected with the two supporting bodies; the blocking body Tangent to the blocking seat body.6.根据权利要求2所述的血桥限位器，其中，所述障碍体所在面与两个所述支撑体所在面相平行。6 . The blood bridge stopper according to claim 2 , wherein the surface where the obstacle is located is parallel to the surfaces where the two supporting bodies are located. 7 .7.根据权利要求2所述的血桥限位器，其中，所述障碍体为圆柱状结构。7. The blood bridge limiter according to claim 2, wherein the obstacle is a cylindrical structure.8.根据权利要求1所述的血桥限位器，其中，所述血管插管连接头座体与两个所述支撑体呈工字型结构。8 . The blood bridge stopper according to claim 1 , wherein the vascular cannula connector base and the two support bodies are in an I-shaped structure. 9 .9.根据权利要求1所述的血桥限位器，其中，所述血管插管连接头座体设置在两个所述支撑体的中线位置，且所述支撑体两端相对于所述血管插管连接头座体相互对称。9 . The blood bridge stopper according to claim 1 , wherein the vascular cannula connector seat body is arranged at the midline position of the two support bodies, and both ends of the support body are opposite to the blood vessel. 10 . The socket bodies of the cannula connectors are symmetrical to each other.10.根据权利要求1所述的血桥限位器，其中，所述支撑体两端侧壁各设置一个卡扣，所述约束环通过卡扣与所述支撑体固定连接。10 . The blood bridge stopper according to claim 1 , wherein each side wall at both ends of the support body is provided with a buckle, and the restraint ring is fixedly connected to the support body through the buckle. 11 .

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