CN113017914A - Peripheral blood vessel composite stent for preventing intimal hyperplasia at access opening of covered stent - Google Patents

Abstract

Translated fromChinese

本发明涉及一种防止覆膜支架出入口内膜增生的外周血管复合支架，所述复合支架包括内层覆膜支架本体；所述覆膜支架本体两端出入口处设有外层支架；所述外层支架为普通裸支架，且外层支架为“Z”型金属丝连接而成并通过金属丝与内层覆膜支架金属丝相连。其优点表现在：通过在覆膜支架主体两端出入口处设有外层支架，可以避免覆膜支架本体两端出口与内膜接触而反复刺激内膜导致其增长入管腔堵塞支架口，从物理层面使覆膜支架本体开口不接触血管内膜，防止增生堵塞覆膜支架本体两端开口，保持支架长期通畅；外层支架防止内层覆膜支架本体端口直接接触管壁的同时有意使裸支架刺激内膜增生并达到稳定，避免牺牲覆膜支架本体开口空间。

The invention relates to a peripheral vascular composite stent for preventing intimal hyperplasia at the entrance and exit of the covered stent. The composite stent comprises an inner-layer covered stent body; the entrances and exits of both ends of the covered stent body are provided with outer-layer stents; The layer stent is an ordinary bare stent, and the outer layer stent is connected by a "Z"-shaped metal wire, and is connected to the inner layer stent-graft metal wire through the metal wire. Its advantages are shown in: by providing outer layer stents at the entrances and exits of both ends of the main body of the stent graft, it can avoid the contact between the two ends of the stent graft body and the intima, which can repeatedly stimulate the intima and cause it to grow into the lumen and block the stent openings. Physically, the opening of the stent-graft body does not contact the intima of the blood vessel, preventing hyperplasia from blocking the openings at both ends of the stent-graft body, and maintaining long-term patency of the stent; the outer-layer stent prevents the inner-layer stent-graft body port from directly contacting the vessel wall, and at the same time, it is intentionally exposed. The stent stimulates intimal hyperplasia and achieves stability, avoiding sacrificing the opening space of the stent-graft body.

Description

Peripheral blood vessel composite stent for preventing intimal hyperplasia at access opening of covered stent

Technical Field

The invention relates to the technical field of medical stents, in particular to a peripheral vascular composite stent for preventing intimal hyperplasia at an entrance and an exit of a covered stent.

Background

The former stents are divided into bare stents and covered stents, which have advantages and disadvantages respectively. After the main trunk of the peripheral blood vessel is occluded, a new tiny bypass lateral branch can grow out spontaneously in the occluded section to relieve the remote ischemia as much as possible. After the main blood vessel is artificially opened and blocked in the cavity, no intimal hyperplasia can be prevented by any method. The naked stent has the advantages that the whole body of the stent is in the metal grid shape, the lateral branches cannot be covered after the stent is placed in a blood vessel, the lateral branches can still supply blood for the far end after the stent is occluded due to the fact that the hyperplasia intima grows into the stent in the long term, but the naked stent has the greatest defect that the hyperplasia is easy to grow into the stent due to the grid shape. The covered stent can completely prevent hyperplastic intima from growing into the stent, but the covered stent has the unique defect that the places where outlets at two ends of the stent are contacted with blood vessels are still hyperplastic, the hyperplastic at the two ends can also cause the covered stent to be occluded, and because the covered stent blocks the hyperplastic and covers the lateral branches, the ischemia caused by the covered stent is usually heavier in the degree of ischemia of the far-end limb.

Chinese patent documents: CN201711446072.9, application date 2017.12.27, patent names: a blood vessel support with absorbable coating. Discloses a vascular stent with an absorbable covering membrane, which comprises a tubular stent and a covering membrane unit; the tubular support is a flexible tubular structure and comprises a near end, a middle part and a far end which are sequentially arranged; the film covering unit is coated on the tubular stent; the film covering unit is made of degradable high polymer material.

Chinese patent documents: CN201110097517.3, application date 2011.04.13, patent names: a biodegradable stent having a multilayer coating. A biodegradable stent having a multi-layer coating is disclosed. The stent can also comprise at least two layers of a drug coating layer, an endothelial cell growth promoting layer and a development control layer besides a stent main body with a supporting function. The main material of the stent is a biodegradable polymer with higher mechanical strength, and after the stent is implanted into a diseased position, the stent has strong supporting force and can play a role in supporting diseased blood vessels in a short time. The development control layer can help doctors to accurately observe the position of the stent and the expansion consistency of the stent in an operation, and prevent adverse events such as displacement, instant collapse and the like.

In the patent document CN201711446072.9, a stent with an absorbable coating adopts a flexible tubular stent and a coating unit wrapped on a coronary stent, and the coating unit in the invention can be absorbed by biological tissues, so as to reduce the risk of intimal hyperplasia and restenosis, maintain a normal blood flow channel, and treat angiostenosis more effectively; in the patent document CN201110097517.3, a biodegradable stent with a multilayer coating is adopted, and the stent can include at least two layers of a drug coating, an endothelial cell growth promoting layer and a development control layer in addition to a stent main body with a supporting function, and the drug for inhibiting intimal hyperplasia in the drug coating can prevent the restenosis of blood vessels in a short period after the stent is implanted; the endothelial cell growth promoting layer can promote the growth of endothelial cells on the surface of the stent, and the stent is wrapped in the vascular endothelium so as to prevent the degradation fragments of the stent from falling into blood to cause embolism. However, there is no report on a peripheral vascular composite stent capable of preventing intimal hyperplasia at the entrance and the exit of a stent graft from contacting with an autologous blood vessel from a physical layer to avoid hyperplasia and occlusion, and keeping the stent smooth for a long time.

In view of the above, there is a need for a peripheral vascular composite stent capable of preventing intimal hyperplasia at the access opening of a stent graft from contacting with the autologous blood vessel from the physical aspect to avoid hyperplasia and occlusion of the stent graft and keep the stent unobstructed for a long time.

Disclosure of Invention

The invention aims to overcome the defects of the prior art and provide a peripheral vascular composite stent which can prevent the access ports at the two ends of the stent graft from contacting with autologous blood vessels from the physical aspect, avoid hyperplasia and block the stent graft and keep the stent smooth for a long time.

In order to achieve the purpose, the invention adopts the technical scheme that:

a peripheral vascular composite stent for preventing intimal hyperplasia at an access of a covered stent comprises an inner-layer covered stent body; an outer layer bracket is arranged at the inlet and outlet of the two ends of the covered stent body; the outer layer bracket is a common naked bracket.

As a preferable technical scheme, the outer layer stent is formed by connecting Z-shaped metal wires and is connected with the inner layer covered stent metal wires through the metal wires.

The invention has the advantages that:

1. through the design that is equipped with outer support in tectorial membrane support main part both ends entrance and exit, can avoid tectorial membrane support body both ends export and inner membrance contact and amazing inner membrance repeatedly and lead to it to increase into the lumen and block up a support mouth, can follow the physical aspect and make tectorial membrane support body opening contactless blood vessel inner membrance to prevent that the hyperplasia from blockking up tectorial membrane support body both ends opening, keep the support unobstructed for a long time.

2. The composite stent is integrally similar to a common covered stent, and is mainly characterized in that a layer of bare stent is added outside the outlets at two ends of a covered stent body to achieve the purpose of opening a space for an inner-layer covered stent body, so that the bare stent is intentionally used for stimulating intimal hyperplasia and achieving stability while the port of the inner-layer covered stent body is prevented from directly contacting with the tube wall, and the opening space of the covered stent body is prevented from being sacrificed.

Drawings

FIG. 1 is a schematic plane structure diagram of a peripheral vascular composite stent for preventing intimal hyperplasia at an access opening of a covered stent.

FIG. 2 is a schematic diagram of the hyperplasia of the clinical bare stent after the long section is placed.

Detailed Description

The invention is further described with reference to the following examples and with reference to the accompanying drawings.

The reference numerals and components referred to in the drawings are as follows:

1. compositestent body 11, outer stent

Example 1

Referring to fig. 1, fig. 1 is a schematic plan view of a peripheral vascular composite stent for preventing intimal hyperplasia at an access port of a stent graft according to the present invention. A peripheral vascular composite stent for preventing intimal hyperplasia at an access of a covered stent comprises an inner-layer coveredstent body 1; anouter layer bracket 11 is arranged at the inlet and outlet of the two ends of the coveredstent body 1; theouter layer bracket 11 is a common naked bracket; the outer-layer stent 11 is formed by connecting Z-shaped metal wires and is connected with the inner-layer covered stent metal wires through the metal wires.

It should be noted that: the design that the outer-layer stent 11 is arranged at the inlet and outlet positions at the two ends of themain body 1 of the covered stent can prevent outlets at the two ends of themain body 1 of the covered stent from contacting with the inner membrane to repeatedly stimulate the inner membrane to cause the inner membrane to grow into a lumen to block the stent opening, and the composite stent can ensure that the opening of themain body 1 of the covered stent does not contact with the inner membrane of a blood vessel from a physical layer, thereby preventing the openings at the two ends of themain body 1 of the covered stent from being blocked by hyperplasia; the composite stent is integrally similar to a common covered stent, and is mainly characterized in that a layer of bare stent is added at the outlets of two ends of a coveredstent body 1 to achieve the purpose of opening the space for an inner-layer coveredstent body 1, so that the bare stent is intentionally used for stimulating intimal hyperplasia and achieving stability while the port of the inner-layer coveredstent body 1 is prevented from directly contacting the tube wall, and the opening space of the coveredstent body 1 is prevented from being sacrificed;

the design principle of the composite bracket of the invention is as follows: in clinic, a plurality of bare stents are used, the long-term hyperplasia occlusion of the bare stents is almost inevitable, especially long-section stents are implanted, but the hyperplasia of the bare stents has the characteristics, the hyperplasia characteristics of the hyperplasia parts in the bare stents in clinic are inward arc-shaped growth (see two circled positions in figure 2), the arc-shaped growth cannot be avoided, but if a covered stent is placed in the arc-shaped hyperplasia, the opening of the covered stent is positioned at the arc-shaped hyperplasia opening, so that the inner-layer covered stent can be prevented from directly contacting the far-end autologous vascular wall of the bare stent;

the use method of the composite bracket comprises the following steps: before releasing, the composite stent is in a compressed state, before releasing, a saccule with the same caliber as that of the outer-layer bare stent is used for expanding the lumen of the target blood vessel, then the composite stent is released, and after releasing, two ends of the composite stent are fixed in the blood vessel by virtue of the expansion force of the outer-layer bare stent;

according to the peripheral vascular composite stent for preventing intimal hyperplasia at the entrance and exit of the covered stent, due to the design that the outer layer stent is arranged at the entrance and exit at the two ends of the main body of the covered stent, the situation that the exits at the two ends of the covered stent body are in contact with the intimal to repeatedly stimulate the intimal to cause the intimal to grow into a lumen to block the stent opening can be avoided, the opening of the covered stent body can not be in contact with the vascular intimal from a physical layer, so that the openings at the two ends of the covered stent body are prevented from being blocked by hyperplasia, and the; the composite stent is integrally similar to a common covered stent, and is mainly characterized in that a layer of bare stent is added outside the outlets at two ends of a covered stent body to achieve the purpose of opening a space for an inner-layer covered stent body, so that the bare stent is intentionally used for stimulating intimal hyperplasia and achieving stability while the port of the inner-layer covered stent body is prevented from directly contacting with the tube wall, and the opening space of the covered stent body is prevented from being sacrificed.

The foregoing is only a preferred embodiment of the present invention, and it should be noted that, for those skilled in the art, various modifications and additions can be made without departing from the principle of the present invention, and these should also be considered as the protection scope of the present invention.

Claims (2)

Translated fromChinese

1.一种防止覆膜支架出入口内膜增生的外周血管复合支架，其特征在于，所述的防止覆膜支架出入口内膜增生的外周血管复合支架包括内层覆膜支架本体；所述的覆膜支架本体两端出入口处设有外层支架；所述的外层支架为普通裸支架。1. a peripheral vascular composite stent for preventing the intimal hyperplasia of the entrance and exit of the stent-graft, it is characterized in that, the described peripheral vascular composite stent for preventing the intimal hyperplasia of the entrance and exit of the stent-graft comprises an inner layer stent-graft body; Outer layer brackets are arranged at the entrances and exits of the two ends of the membrane bracket body; the outer layer brackets are ordinary bare brackets.2.根据权利要求1所述的防止覆膜支架出入口内膜增生的外周血管复合支架，其特征在于，所述的外层支架为“Z”型金属丝连接而成并通过金属丝与内层覆膜支架金属丝相连。2 . The peripheral vascular composite stent for preventing intimal hyperplasia at the entrance and exit of the stent-graft according to claim 1 , wherein the outer layer stent is formed by connecting a “Z”-shaped metal wire and is connected to the inner layer through the metal wire. 3 . The stent-graft wire is connected.

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