CN112730277A - Automatic analyzer and reagent library thereof - Google Patents
Automatic analyzer and reagent library thereofDownload PDFInfo
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- CN112730277A CN112730277ACN202010833986.6ACN202010833986ACN112730277ACN 112730277 ACN112730277 ACN 112730277ACN 202010833986 ACN202010833986 ACN 202010833986ACN 112730277 ACN112730277 ACN 112730277A
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
- G01N21/25—Colour; Spectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands
- G01N21/31—Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/01—Arrangements or apparatus for facilitating the optical investigation
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/10—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N2035/00346—Heating or cooling arrangements
- G01N2035/00435—Refrigerated reagent storage
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Abstract
Description
Technical Field
The present invention relates to an automatic analyzer and a reagent kit for analyzing components of a test sample extracted from a subject, and more particularly, to an automatic analyzer and a reagent kit for analyzing components contained in a body fluid such as human blood or urine, which can be cooled.
Background
The automatic analyzer measures changes in color tone and the like caused by a reaction between a test sample dispensed into a reaction vessel and a mixed solution of reagents suitable for each item, for biochemical test items, immunological test items and the like, to determine the concentrations of various components in the test sample and the activity of enzymes. In this automatic analyzer, measurement of an item selected in accordance with an examination is performed from among a large number of items that can be measured by setting analysis conditions for each test sample. Then, a reagent suitable for the test sample and the selected item is dispensed into the reaction container by the sample and reagent dispensing probe, and the dispensed mixture of the test sample and the reagent is stirred by the stirrer and measured by the photometry section.
Incidentally, reagent containers containing reagents of which the number of items can be measured are stored in a reagent reservoir composed of a reagent reservoir well and a reagent reservoir lid, and the stored reagent containers are kept cold to prevent deterioration of analysis data due to denaturation of the reagents. As a method of cooling the reagent container, a cooling method is known in which a coolant is fed into the reagent chamber by using a fan to cool the periphery of the reagent container.
However, in the method of feeding the refrigerant into the reagent storage, when a large number of reagent containers are stored, it is difficult to apply cold air between the reagent containers and to uniformly keep the reagent containers cold. In addition, in an automatic analysis device that handles a large number of inspection items, there is a problem in that: since it is necessary to arrange a plurality of reagents, it takes time to cool the inside of such a large reagent storage to a predetermined temperature by using a large reagent storage such as a double reagent storage in which reagent containers can be arranged in a double concentric circle.
Disclosure of Invention
The invention aims to provide an automatic analyzer and a reagent storage thereof, which can uniformly and effectively keep the interior of the reagent storage cold.
In order to achieve the above object, an automatic analyzer according to an embodiment of the present invention includes: a sample dispensing arm, a reagent dispensing arm, a photometric unit, and a reagent storage. The sample dispensing arm dispenses a test sample from a sample container containing the test sample into a reaction container. The reagent dispensing arm dispenses a reagent from a reagent container containing the reagent into the reaction container. And the photometric unit performs photometry on the mixed liquid in the reaction container. The reagent library has: a reagent storage tank for storing the reagent container; a reagent reservoir cover covering the reagent reservoir groove; a conduit disposed along a wall surface of the reagent reservoir tank; a cooling section for cooling the refrigerant; and a flow pump connected to a start end and a finish end of the conduit to flow the refrigerant in the conduit.
Further, a reagent library of an automatic analyzer according to an embodiment of the present invention includes: reagent storehouse groove, reagent storehouse lid, pipe, cooling part and flow pump. The reagent storage tank stores a reagent container that contains a reagent used for analysis in the automatic analyzer.
A reagent reservoir cover covers the reagent reservoir trough. The conduit is disposed along a wall surface of the reagent reservoir tank. The cooling unit cools the refrigerant. A flow pump flows the refrigerant in the conduit.
According to the present embodiment, the conduit is disposed along the wall surface of the reagent storage tank, and the refrigerant is made to flow through the conduit, whereby the inside of the reagent storage tank can be uniformly and effectively cooled.
Drawings
Fig. 1 is a diagram showing a configuration of an automatic analyzer according to an embodiment of the present invention;
FIG. 2 is a view showing the direction A-A of the first reagent library of FIG. 1 according to the first embodiment of the present invention;
FIG. 3 is a view showing the direction A-A of the first reagent library of FIG. 1 according to the second embodiment of the present invention;
FIG. 4 is a view showing the direction A-A of the first reagent library of FIG. 1 according to the third embodiment of the present invention;
FIG. 5 is a schematic view of the bottom of the first reagent magazine of FIG. 1 according to the ninth embodiment of the present invention;
FIG. 6 is a view showing the direction A-A in the first reagent storage of FIG. 1 according to the fourth embodiment of the present invention;
FIG. 7 is an A-A view of the first reagent library of FIG. 1 according to a fifth embodiment of the present invention;
FIG. 8 is a view showing the direction A-A of the first reagent library of FIG. 1 according to the sixth embodiment of the present invention;
FIG. 9 is a view showing the direction A-A of the first reagent library of FIG. 1 according to the seventh embodiment of the present invention;
FIG. 10 is a view showing the direction A-A of the first reagent library of FIG. 1 according to the eighth embodiment of the present invention;
FIG. 11 is a view showing the direction A-A in the first reagent storage of FIG. 1 according to the eleventh embodiment of the present invention;
fig. 12 is a control flowchart of the refrigerant flow path according to the eighth embodiment of the present invention;
fig. 13 is a schematic view showing the arrangement of a catheter on a reagent cartridge cover according to a tenth embodiment of the present invention.
Detailed Description
An embodiment of an automatic analyzer according to the present invention will be described below with reference to fig. 1 to 13.
Fig. 1 is a diagram showing a configuration of an automatic analyzer according to an embodiment of the present invention. Theautomatic analyzer 100 includes: ananalysis unit 1 having an analysis means for measuring a standard sample and a test sample for each item; ananalysis control unit 2 that controls the measurement operation of each analysis cell in theanalysis unit 1; and adata processing unit 3 for generating a calibration curve and analysis data by performing measurement processing on the standard sample and the test sample and outputting the standard sample data and the test sample data from theanalysis unit 1.
Theanalysis unit 1 includes: asample container 4 for storing samples such as a standard sample and a test sample; adisk sampler 5 that rotatably holds thesample container 4; areagent container 6 that contains a first reagent for analyzing a component of each item contained in a sample; and afirst reagent storage 7 having a holding portion for rotatably holding thereagent container 6 and a reagent storage groove for storing the holding portion.
In addition, the method comprises the following steps: areader 8 for reading information of the barcode label attached to thereagent container 6; a reagent container 9 that accommodates a second reagent that mates with the first reagent; asecond reagent storage 10 having a holding portion for rotatably holding the reagent container 9 and a reagent storage groove for accommodating the holding portion; and areader 11 for reading information of the barcode label attached to the reagent container 9.
Further, the device is provided with: asample dispensing arm 13 that holds a sample dispensing probe that performs dispensing by sucking a sample out of thesample container 4 and discharging the sample into thereaction container 12, so as to be rotatable and liftable; a firstreagent dispensing arm 14 that holds a first reagent dispensing probe for performing dispensing by sucking a first reagent from thereagent container 6 in thefirst reagent storage 7 and discharging the first reagent into thereaction container 12, so as to be rotatable and movable up and down; and a secondreagent dispensing arm 15 that holds a second reagent dispensing probe for performing dispensing by sucking a second reagent from thesecond reagent storage 10 and discharging the second reagent into thereaction vessel 12 so as to be rotatable and movable up and down.
Further, the device is provided with: areaction disk 16 that holds a plurality ofreaction containers 12 that are arranged on the circumference of the circle so as to be rotatable and movable and that accommodate the sample, the first reagent, and the second reagent discharged from each dispensing probe; a stirringunit 17 that stirs a mixture of the sample and the first reagent dispensed into thereaction container 12 and a mixture of the sample, the first reagent, and the second reagent; aphotometric unit 18 that measures thereaction container 12 in which each of the mixed solutions is stored (that is, thephotometric unit 18 measures the light of the mixed solution in the reaction container 12); and acleaning unit 19 for holding a cleaning nozzle for cleaning the inside of thereaction vessel 12 while sucking out each mixed liquid in the measured inside of thereaction vessel 12 and a drying nozzle for drying the inside of thereaction vessel 12 so as to be movable up and down.
Thephotometric unit 18 irradiates therotating reaction vessel 12 with light, converts the light transmitted through the mixture solution containing the standard sample into absorbance, generates standard sample data, and outputs the standard sample data to thedata processing unit 3. The light transmitted through the liquid mixture containing the test sample is converted into absorbance to generate test sample data, and then the test sample data is output to thedata processing unit 3. Further, each analysis cell such as thereaction vessel 12, the sample dispensing probe of thesample dispensing arm 13, the first reagent dispensing probe of the firstreagent dispensing arm 14, the second reagent dispensing probe of the secondreagent dispensing arm 15, and thestirring unit 19 after the measurement is cleaned is used again for the measurement.
Theanalysis control unit 2 includes: amechanism section 20 including a mechanism that drives each analysis unit of theanalysis section 1; and acontrol section 21 that controls each of the mechanisms of themechanism section 20. Themechanism unit 20 includes: a mechanism for rotating the holding portion of thefirst reagent storage 7, the holding portion of thesecond reagent storage 10, and thedisk sampler 5; a mechanism for rotating thereaction disk 16; a mechanism for rotating and moving up and down thesample dispensing arm 13, the firstreagent dispensing arm 14, the secondreagent dispensing arm 15, and thestirring unit 17; and a mechanism for moving thecleaning unit 19 up and down.
Further, the apparatus comprises: a mechanism for driving a sample dispensing pump that sucks and discharges a sample from a sample dispensing probe of thesample dispensing arm 13; a mechanism for driving a first reagent pump that aspirates and discharges a first reagent from a first reagent dispensing probe of the firstreagent dispensing arm 14; a mechanism for driving a second reagent pump that aspirates and discharges a second reagent from a second reagent dispensing probe of the secondreagent dispensing arm 15; a mechanism for stirring the stirring members of the drivingstirring unit 17; a mechanism for driving a cleaning pump that sucks the mixed liquid from the cleaning nozzle of thecleaning unit 19 and discharges and sucks the cleaning liquid; and a mechanism for driving a drying pump that sucks out from the drying nozzle of thecleaning unit 19. Next, the configuration of thefirst reagent storage 7 and thesecond reagent storage 10 in theanalyzer 1 will be described in detail with reference to fig. 2. Here, thefirst reagent storage 7 as a double reagent storage will be described as an example.
In fig. 2, thefirst reagent reservoir 7 includes: areagent storage tank 200 for storing thereagent container 6; a detachablereagent storage cover 202 for covering the reagent storage well 200; afirst holding portion 203 and a second holding portion 204 (thefirst holding portion 203 and thesecond holding portion 204 are concentric table-shaped) which rotatably hold thereagent vessel 6 stored in the reagent well 200; a first motor (drive mechanism) 205 that rotates thefirst holding portion 203; a second motor (drive mechanism) 206 that rotates thesecond holding portion 204; aconduit 207 disposed along the wall surface of thereagent reservoir tank 200; acooling unit 208 for cooling the refrigerant; and aflow pump 209 connected to the beginning and end of theconduit 207 to flow the refrigerant in theconduit 207. Thefirst reagent storage 7 includes aheat insulating portion 201 that insulates thereagent storage groove 200 outside thereagent storage groove 200.
Referring to fig. 5, adrain opening 502 is formed in abottom 500 of thereagent reservoir tank 200 of thefirst reagent reservoir 7, and thedrain opening 502 is used to drain dew condensation water generated by cooling the inside of thefirst reagent reservoir 7 to the outside of thefirst reagent reservoir 7.
Further, in order to rotate thefirst holding portion 203 and thesecond holding portion 204 that hold thereagent vessel 6 stored in the reagent storage well 200, atransmission portion 503 is formed at the bottom of the reagent storage well 200, and thetransmission portion 503 is used to transmit the power of thefirst motor 205 and thesecond motor 206 provided outside the reagent storage well 200 to thefirst holding portion 203 and thesecond holding portion 204 in the reagent storage well 200 through a transmission mechanism such as a gear and a cam.
Several configurations of theconduit 207 within thefirst reagent reservoir 7 are described below:
(first embodiment)
FIG. 2 is a view showing the direction A-A of the first reagent library of FIG. 1 according to the first embodiment of the present invention.
Theconduit 207 has a plurality of conduit layers in the height direction of the side surface of thereagent reservoir tank 200. Theguide tube 207 may be plural or may be one. When theconduit 207 is plural, the plural conduits are arranged along the side surface of thereagent reservoir tank 200 in the height direction, and the respective conduits at different positions in the height direction form respective conduit layers in the height direction of theconduit 207; when theguide tube 207 is one, one guide tube is arranged to extend spirally along the side surface of thereagent reservoir tank 200 in the height direction of thereagent reservoir tank 200, whereby the respective guide tube layers in the height direction of theguide tube 207 are formed by one guide tube.
As shown in fig. 2, the respective conduit layers of theconduit 207 are arranged parallel to each other with respect to the height direction of the side surface of thereagent reservoir tank 200. With this configuration, the conduit is disposed along the side surface of thereagent reservoir tank 200, and a refrigerant (for example, a liquid such as water or a gas) is caused to flow through the conduit, whereby the inside of the reagent reservoir can be uniformly and efficiently cooled.
Further, in the present embodiment, theconduit 207 is configured in the following manner: in the height direction of the side surface of thereagent reservoir tank 200, the interval between the plurality of conduit layers disposed at the higher position is smaller than the interval between the plurality of conduit layers disposed at the lower position. For example, in fig. 2, the conduits are arranged such that the density of conduit layers is increased in a region B which is a higher position in the height direction of the side surface of thereagent reservoir tank 200 and the interval between adjacent conduit layers is smaller than the interval between adjacent conduit layers in a region other than the region B.
In general, in order to open thereagent storage lid 202 when thereagent vessel 6 is stored in thereagent storage groove 200 and in order to suck out the reagent from thereagent vessel 6 by the firstreagent dispensing arm 14 in a state where thefirst reagent storage 7 is covered with thereagent storage lid 202, a hole is formed in thereagent storage lid 202 near the reagent suction port of thereagent vessel 6, whereby it is difficult to maintain a cooling effect (uniform cooling) in a higher region (region close to the reagent storage lid 202) of the side surface of thereagent storage groove 200 in thefirst reagent storage 7 than in a lower region (region close to the bottom of the reagent storage groove 200) of the side surface of thereagent storage groove 200 in thefirst reagent storage 7. In the present embodiment, since the conduits are arranged such that the density of the conduit layers is increased in a higher position, i.e., in the region B, and the interval between adjacent conduit layers is smaller than the interval between adjacent conduit layers in the region other than the region B in the height direction of the side surface of thereagent reservoir tank 200, the cooling effect of the higher region of the side surface of thereagent reservoir tank 200 in the first reagent reservoir 7 (the region close to the reagent reservoir cover 202) is higher than the cooling effect of the lower region of the side surface of thereagent reservoir tank 200 in the first reagent reservoir 7 (the region close to the bottom of the reagent reservoir tank 200), and therefore, it is possible to suppress the temperature rise of the region close to thereagent reservoir cover 202 due to the opening and closing of thereagent reservoir cover 202 and the like, and maintain the uniformity of the cooling.
Further, when theguide tube 207 is viewed from above in fig. 2, theguide tube 207 is disposed in a region covering a part of the side surface of thereagent reservoir tank 200 in the circumferential direction of the side surface of thereagent reservoir tank 200. That is, theguide tube 207 is formed in a circular arc shape in the circumferential direction of the side surface of thereagent reservoir tank 200 as viewed in the height direction of the side surface of thereagent reservoir tank 200, whereby the manufacturing cost of the guide tube can be reduced. In order to achieve a better cooling effect, theduct 207 should be disposed in a region having a length of at least 90% of the circumferential direction of the side surface of thereagent reservoir tank 200.
In addition, when theconduit 207 is constituted by an arrangement in which one conduit extends spirally along the side surface of thereagent reservoir groove 200 in the height direction of thereagent reservoir groove 200, theconduit 207 is formed in a spiral shape in the circumferential direction of the side surface of thereagent reservoir groove 200 as viewed in the height direction of the side surface of thereagent reservoir groove 200, and at this time theconduit 207 is arranged in the region of the entire length of the side surface of thereagent reservoir groove 200 in the circumferential direction.
In addition, theguide tube 207 may be formed in a circular shape along the circumferential direction of the side surface of thereagent reservoir tank 200. In this case, theguide tube 207 is disposed over the entire circumferential length of the side surface of thereagent reservoir tank 200.
That is, theconduit 207 has at least one of a circular shape, a spiral shape, or a circular arc shape in the circumferential direction of the side surface of thereagent reservoir tank 200, and is arranged at least in a region of 90% or more of the length of the side surface of thereagent reservoir tank 200 in the circumferential direction.
(second embodiment)
FIG. 3 is a view showing the direction A-A of the first reagent kit of FIG. 1 according to the second embodiment of the present invention.
Theconduit 207 has a plurality of conduit layers in the height direction of the side surface of thereagent reservoir tank 200. Theguide tube 207 may be plural or may be one. When theconduit 207 is plural, the plural conduits are arranged along the side surface of thereagent reservoir tank 200 in the height direction, and the respective conduits at different positions in the height direction form respective conduit layers in the height direction of theconduit 207; when theguide tube 207 is one, one guide tube is arranged to extend spirally along the side surface of thereagent reservoir tank 200 in the height direction of thereagent reservoir tank 200, whereby the respective guide tube layers in the height direction of theguide tube 207 are formed by one guide tube.
As shown in fig. 3, the respective conduit layers of theconduit 207 are arranged parallel to each other with respect to the height direction of the side surface of thereagent reservoir tank 200. With this configuration, the conduit is disposed along the side surface of the reagent storage tank, and the refrigerant is caused to flow through the conduit, whereby the inside of the reagent storage tank can be uniformly and efficiently cooled.
Further, in the present embodiment, there are positions on the side surface of thereagent reservoir tank 200 where the temperature is susceptible to external factors, for example, the wiring and the throughhole 301 for the sensor formed between the outside and the inside of thereagent reservoir tank 200, and the throughhole 301 is explained below as an example:
around the throughhole 301, a sub-duct 302 is disposed as a branch of theduct 207, that is, the duct layer of theduct 207 adjacent to the throughhole 301 formed on the side surface of thereagent reservoir tank 200 forms the sub-duct 302 as a branch thereof.
Such a throughhole 301 also passes through theheat insulating portion 201, and the air in thefirst reagent reservoir 7 is in contact with the outside air through the throughhole 301, and therefore the cooling effect near the throughhole 301 is poor. In the present embodiment, the sub-pipe 302, which is a branch of thepipe 207, is formed and arranged around the through-hole 301, and the refrigerant is also circulated in the sub-pipe 302, whereby the flow field area where the refrigerant flows around the through-hole 301 can be increased, the cooling effect in the vicinity of the through-hole 301 can be improved, and the temperature rise in the vicinity of the through-hole 301 can be suppressed to maintain the uniformity of cooling.
(third embodiment)
FIG. 4 is a view showing the direction A-A of the first reagent kit in FIG. 1 according to the third embodiment of the present invention.
Theconduit 207 has a plurality of conduit layers in the height direction of the side surface of thereagent reservoir tank 200. Theguide tube 207 may be plural or may be one. When theconduit 207 is plural, the plural conduits are arranged along the side surface of thereagent reservoir tank 200 in the height direction, and the respective conduits at different positions in the height direction form respective conduit layers in the height direction of theconduit 207; when theguide tube 207 is one, one guide tube is arranged to extend spirally along the side surface of thereagent reservoir tank 200 in the height direction of thereagent reservoir tank 200, whereby the respective guide tube layers in the height direction of theguide tube 207 are formed by one guide tube.
As shown in fig. 4, the respective conduit layers of theconduit 207 are arranged parallel to each other with respect to the height direction of the side surface of thereagent reservoir tank 200. With this configuration, the conduit is disposed along the side surface of the reagent storage tank, and the refrigerant is caused to flow through the conduit, whereby the inside of the reagent storage tank can be uniformly and efficiently cooled.
Further, in the present embodiment, there are positions on the side surface of thereagent reservoir tank 200 where the temperature is susceptible to external factors, for example, the wiring and the throughhole 301 for the sensor formed between the outside and the inside of thereagent reservoir tank 200, and the throughhole 301 is explained below as an example:
a bentconduit pipe portion 401 formed in the conduit layer of theconduit 207 adjacent to the throughhole 301 in the height direction along the side surface of thereagent reservoir tank 200, and the bentconduit pipe portion 401 is arranged in the vicinity of the throughhole 301.
Such a throughhole 301 also passes through theheat insulating portion 201, and the air in thefirst reagent reservoir 7 is in contact with the outside air through the throughhole 301, and therefore the cooling effect near the throughhole 301 is poor. In the present embodiment, by disposing thebent conduit portion 401 of theconduit 207 in the vicinity of the throughhole 301 and circulating the refrigerant through thebent conduit portion 401, the flow field area where the refrigerant flows around the throughhole 301 can be enlarged, the cooling effect in the vicinity of the throughhole 301 can be improved, and the temperature rise in the vicinity of the throughhole 301 can be suppressed to maintain the uniformity of cooling.
(fourth embodiment)
FIG. 6 is a view showing the direction A-A of the first reagent kit in FIG. 1 according to the fourth embodiment of the present invention.
Theconduit 207 has afirst portion 303 and asecond portion 304 which are arranged in the height direction of the side surface of thereagent reservoir tank 200 and independently complete the refrigerant cycle, and each of thefirst portion 303 and thesecond portion 304 has a plurality of conduit layers, and as described with reference to fig. 6, taking an example in which thefirst portion 303 is arranged in the upper half of the side surface of the reagent reservoir tank and thesecond portion 304 is arranged in the lower half of the side surface of the reagent reservoir tank, thefirst portion 303 and thesecond portion 304 are arranged in the height direction of thereagent reservoir tank 200 so as to extend spirally along the side surface of thereagent reservoir tank 200, and thereby thefirst portion 303 and thesecond portion 304 form each conduit layer in the height direction of the side surface of the reagent reservoir tank.
Since the cold air has a relatively high specific gravity and is generally located at a lower position in the reagent storage well 200, the temperature of the upper position of thereagent storage well 200 is higher than that of the lower position thereof, and therefore, the pipe diameter of thefirst portion 303 near the upper position (i.e., the position near the reagent storage lid 202) is set to be larger than the pipe diameter of thesecond portion 304 near the bottom position of the reagent storage well 200, so that the temperature inside the reagent storage well 200 can be kept relatively uniform from top to bottom.
The respective conduit layers of thefirst portion 303 and thesecond portion 304 are arranged parallel to each other with respect to the height direction of the side surface of thereagent reservoir tank 200. The refrigerants independently circulate in thefirst portion 303 and thesecond portion 304, and two independent refrigerant circulations are formed at the upper position and the lower position of the side surface of thereagent storage tank 200, so that the interior of thefirst reagent storage 7 can be effectively kept cold, and the pipe diameter of thefirst portion 303 can be set to be larger than that of thesecond portion 304 according to the temperature difference between the upper position and the lower position of thereagent storage tank 200, so that the surface area of thefirst portion 303 at the upper position is larger, and the cold keeping effect is improved.
In addition, the distribution of the individual conduit layers of thefirst portion 303 may be arranged more densely than thesecond portion 304. It is also possible to provide different refrigerants infirst portion 303 andsecond portion 304 such that the cooling effect offirst portion 303 is higher in the upper position than the cooling effect ofsecond portion 304 in the lower position.
(fifth embodiment)
FIG. 7 is a view showing the direction A-A of the first reagent kit in FIG. 1 according to the fifth embodiment of the present invention.
Since the temperature at the opening for reagent introduction is high, the conduit is configured to have thefirst portion 303 and thesecond portion 304 which are alternately arranged in the height direction of the side surface of thereagent reservoir tank 200 and independently complete the refrigerant circulation, thefirst portion 303 and thesecond portion 304 each have a plurality of conduit layers, the conduit diameter of thefirst portion 303 is larger than that of thesecond portion 304, thefirst portion 303 having a larger conduit diameter can be used when the temperature is high, and thesecond portion 304 having a smaller conduit diameter can be used when the temperature is low.
Wherein, thefirst portion 303 and thesecond portion 304 each have a plurality of conduit layers, thefirst portion 303 and thesecond portion 304 are arranged to extend spirally along the side surface of thereagent reservoir groove 200 in the height direction of thereagent reservoir groove 200, thereby thefirst portion 303 and thesecond portion 304 respectively form each conduit layer in the height direction of the side surface of the reagent reservoir groove, and the conduit layers of thefirst portion 303 and thesecond portion 304 are arranged to stagger at the side surface of thereagent reservoir groove 200, for example, the following layers are arranged in order from top to bottom at the side surface of the reagent reservoir groove: the conduit layers offirst portion 303,second portion 304,first portion 303, andsecond portion 304.
The respective conduit layers of thefirst portion 303 and thesecond portion 304 are arranged parallel to each other with respect to the height direction of the side surface of thereagent reservoir tank 200. The refrigerants independently circulate in thefirst portion 303 and thesecond portion 304, two independent refrigerant circulations are formed on the entire side surface of thereagent reservoir tank 200, and the refrigerant circulations of thefirst portion 303 and thesecond portion 304 are selectively used according to the temperature change in thefirst reagent reservoir 7, whereby the cooling effect can be effectively improved.
(sixth embodiment)
FIG. 8 is a view showing the direction A-A of the first reagent kit in FIG. 1 according to the sixth embodiment of the present invention.
Theconduit 207 has a plurality of conduit layers in the height direction of the side surface of thereagent reservoir tank 200. Theguide tube 207 may be plural or may be one. When theconduit 207 is plural, the plural conduits are arranged along the side surface of thereagent reservoir tank 200 in the height direction, and the respective conduits at different positions in the height direction form respective conduit layers in the height direction of theconduit 207; when theguide tube 207 is one, one guide tube is arranged to extend spirally along the side surface of thereagent reservoir tank 200 in the height direction of thereagent reservoir tank 200, whereby the respective guide tube layers in the height direction of theguide tube 207 are formed by one guide tube.
As shown in fig. 8, the respective conduit layers of theconduit 207 are arranged parallel to each other with respect to the height direction of the side surface of thereagent reservoir tank 200. With this configuration, the conduit is disposed along the side surface of thereagent storage tank 200, and the refrigerant flows through the conduit, so that the inside of the reagent storage tank can be uniformly and efficiently cooled.
Since there is a place where the sealing or heat insulation is insufficient (i.e., a place where the temperature is susceptible to external factors) inside thereagent reservoir tank 200, for example, the wiring between the outside and the inside of thereagent reservoir tank 200 and the throughhole 301 for the sensor are formed on the side surface of thereagent reservoir tank 200, the air inside thereagent reservoir tank 200 may contact with the outside air through the throughhole 301, resulting in poor cold insulation near the throughhole 301.
Therefore, in the present embodiment, at least a part of the conduit layer has the expandedportion 305 having a larger diameter than the conduit layer itself, and the expandedportion 305 is disposed at a position on the side surface of the reagent reservoir tank where the temperature is susceptible to external factors (for example, in the vicinity of the throughhole 301 described above), and by such a configuration, the flow field area of the refrigerant flowing around the throughhole 301 can be enlarged, thereby enhancing the cooling effect in the vicinity of the throughhole 301. The expandingportion 305 is formed by expanding the volume of theguide tube 207 partially outward to have a tube structure larger than the tube diameter of theguide tube 207.
(seventh embodiment)
FIG. 9 is a view showing the direction A-A of the first reagent kit in FIG. 1 according to the seventh embodiment of the present invention.
Theconduit 207 has a plurality of conduit layers in the height direction of the side surface of thereagent reservoir tank 200. Theguide tube 207 may be plural or may be one. When theconduit 207 is plural, the plural conduits are arranged along the side surface of thereagent reservoir tank 200 in the height direction, and the respective conduits at different positions in the height direction form respective conduit layers in the height direction of theconduit 207; when theguide tube 207 is one, one guide tube is arranged to extend spirally along the side surface of thereagent reservoir tank 200 in the height direction of thereagent reservoir tank 200, whereby the respective guide tube layers in the height direction of theguide tube 207 are formed by one guide tube.
As shown in fig. 9, the respective conduit layers of theconduit 207 are arranged parallel to each other with respect to the height direction of the side surface of thereagent reservoir tank 200. With this configuration, the conduit is disposed along the side surface of the reagent reservoir tank, and the refrigerant is made to flow through theconduit 207, whereby the inside of thefirst reagent reservoir 7 can be uniformly and efficiently cooled.
Since there is a place where the sealing or heat insulation is insufficient (i.e., a place where the temperature is susceptible to external factors) inside thereagent reservoir tank 200, for example, the wiring between the outside and the inside of thereagent reservoir tank 200 and the sensor throughhole 301 are formed on the side surface of thereagent reservoir tank 200, the air inside thereagent reservoir tank 200 may contact with the outside air through the throughhole 301, and the cooling effect near the throughhole 301 is poor.
Therefore, in this embodiment, at least a part of the surface of the conduit pipe is provided with theextension piece 306 which deforms by absorbing energy, and theextension piece 306 is disposed at a position (for example, the throughhole 301 described above) on the side surface of thereagent reservoir tank 200 where the temperature is susceptible to external factors, and when the local temperature rises, theextension piece 306 deforms by absorbing heat and spreads to the outside of the conduit pipe, thereby increasing the surface area of the conduit pipe, increasing the cooling effect, and improving the cooling effect near the throughhole 301.
Theextension piece 306 is also arranged at a position on the side surface of the reagent reservoir well 200 where the light is susceptible to external factors (for example, near the open part of the reagent reservoir lid), and when the light is bright at the open part of the reagent reservoir lid, theextension piece 306 deforms and expands to the outside of the conduit layer, thereby increasing the surface area of the conduit and increasing the cooling effect, and improving the cooling effect near the through-hole 301.
If the cross-section of theconduit 207 is polygonal, thespreader 306 may be glued or welded directly to a flat surface of the conduit. If a conduit having a circular or oval cross-section is used, it is not convenient to fix the extendingpiece 306, and the extendingpiece 306 can be fixed by a clamping member, and then the clamping member is fixed outside theconduit 207 by a screw nut.
Theextension sheet 306 is a structure made of deformable functional material, and is generally a sheet-like structure, such as a heat-sensitive metal sheet and a light-sensitive deformable material. And theextension piece 306 is partially fixed to theguide tube 207.
(eighth embodiment)
FIG. 10 is a view showing the direction A-A of the first reagent kit in FIG. 1 according to the eighth embodiment of the present invention.
Theconduit 207 has a plurality of conduit layers in the height direction of the side surface of thereagent reservoir tank 200. Theguide tube 207 may be plural or may be one. When theconduit 207 is plural, the plural conduits are arranged along the side surface of thereagent reservoir tank 200 in the height direction, and the respective conduits at different positions in the height direction form respective conduit layers in the height direction of theconduit 207; when theguide tube 207 is one, one guide tube is arranged to extend spirally along the side surface of thereagent reservoir tank 200 in the height direction of thereagent reservoir tank 200, whereby the respective guide tube layers in the height direction of theguide tube 207 are formed by one guide tube.
As shown in fig. 10, the respective conduit layers of theconduit 207 are arranged parallel to each other with respect to the height direction of the side surface of thereagent reservoir tank 200. With this configuration, the conduit is disposed along the side surface of the reagent storage tank, and the refrigerant is caused to flow through the conduit, whereby the inside of the reagent storage tank can be uniformly and efficiently cooled.
Since there is a place where the sealing or heat insulation is insufficient (i.e., a place where the temperature is susceptible to external factors) inside thereagent reservoir tank 200, for example, the wiring between the outside and the inside of thereagent reservoir tank 200 and the throughhole 301 for the sensor are formed on the side surface of thereagent reservoir tank 200, the air inside thereagent reservoir tank 200 may contact with the outside air through the throughhole 301, resulting in poor cold insulation near the throughhole 301.
Therefore, in this embodiment, at least a part of the pipe layers have across pipe network 307, thecross pipe network 307 is a network structure composed of a plurality of branch pipes, and the refrigerant can flow in each branch pipe. Thecross pipe network 307 is configured to be disposed at a position on a side surface of the reagent reservoir tank where temperature is susceptible to external factors, a temperature sensor for monitoring abnormal temperature is disposed on an inner wall of the reagent reservoir tank on a peripheral side of thecross pipe network 307, electromagnetic valves are disposed at least a plurality of cross nodes on thecross pipe network 307, the electromagnetic valves on the cross nodes realize adjustment of different execution states according to temperature data acquired by the temperature sensor, and thecross pipe network 307 forms a plurality of different refrigerant flow paths according to different execution states of the electromagnetic valves.
The present embodiment further includes at least a control means, and the control means may be theanalysis control unit 2 itself of the automatic analysis device, and the position (high risk position) detected by each temperature sensor corresponds to the refrigerant flow path of one kind of thecross pipe network 307, that is, corresponds to the open/close state of all the electromagnetic valves on one kind of thecross pipe network 307; when the temperature sensor acquires abnormal temperature data (the detected position is called as an abnormal point), the corresponding electromagnetic valve is opened, so that the refrigerant flows through the refrigerant flow path of the abnormal point to achieve the purpose of temperature reduction.
As shown in fig. 12, there is provided a control flow chart of a refrigerant flow path,
s1, starting;
s2: initializing a system;
S3：n＝1,M1＝M2＝…＝Mawhen the electromagnetic valve is not electrified, the flow path is closed
S4: reading the temperature sample value tn
S5：tn≤Tn；
S6：Mn＝0；
S7：Mn＝Mn+1；
S8：Mn≤b；
S9: the nth refrigerant flow path electromagnetic valve is not electrified;
s10: the nth refrigerant flow path electromagnetic valve is electrified and opened;
S11：n＝n+1；
S12：n≤a；
S13：n＝1。
thus, it can be seen that:
setting the number of the temperature sensors as a, each temperature sensor corresponds to one refrigerant flow path, and recording the continuous temperature out-of-tolerance number of the nth temperature sensor as MnNote that each temperature sensor allows the number of consecutive temperature overshoots to be b (b > 0).
In the initial state, the electromagnetic valve is not electrified, the refrigerant flow path is closed, and the temperature sensor monitors the temperature data of the corresponding temperature monitoring point in real time.
When the nth temperature sensor reads the temperature sampling value tnA reference temperature value T smaller than the nth temperature sensornWhen M is in contact withnThe solenoid valve corresponding to the nth refrigerant flow path is not energized.
When the temperature sampling value t read by the nth temperature sensor is larger than the comparison reference temperature value Tn of the nth temperature sensor, Mn＝Mn+1, and when Mn< b, the solenoid valve corresponding to the nth refrigerant flow path is not energized, when MnWhen the number "b" is larger, the solenoid valve corresponding to the nth refrigerant flow path is energized.
And after the temperature out-of-tolerance condition of the nth temperature sensor at the corresponding position in the reagent library groove is judged, the temperature out-of-tolerance condition of the n +1 temperature sensors at the corresponding position in the reagent library groove is continuously judged until all the temperature data collected by the a temperature sensors are analyzed.
When the temperature data collected by the a temperature sensors are completely analyzed, the analysis is started from the beginning.
In the embodiment, the temperature exceeding of the same temperature detection point is continuously determined for b times to confirm that the temperature detection point is a high risk point, and a countermeasure (opening a corresponding refrigerant flow path) can be taken only after the temperature exceeding of the same temperature detection point is determined to be the high risk point, so that the phenomenon of over-low local temperature caused by misjudgment of the high risk point is avoided.
(ninth embodiment)
Fig. 5 is a schematic view of the bottom of the first reagent kit of fig. 1 according to the ninth embodiment of the present invention.
Theguide tube 207 is disposed at the bottom of the reagent reservoir tank, and theentire guide tube 207 is disposed in a radial structure.
Theconduit 207 at the bottom of the reagent well may be disposed simultaneously with theconduit 207 at the side surface of the reagent well (any one of the first to ninth embodiments may be used) or may be disposed independently (theconduit 207 may be disposed only at the bottom of the reagent well).
Since thedrain opening 502 and thetransmission part 503 at the bottom of the reagent storage well also pass through theheat insulating part 201, the air in thefirst reagent storage 7 is in contact with the outside air through thedrain opening 502 and thetransmission part 503, and therefore the cooling effect in the vicinity of thedrain opening 502 and thetransmission part 503 is poor.
In order to improve the cooling efficiency, theheat radiation fins 501 are provided on theduct 207, and the distribution density of theheat radiation fins 501 is increased in the vicinity of thedrain opening 502 and/or thetransmission part 503 formed in thebottom part 500 of thereagent reservoir tank 200 having a high possibility of contact with such outside air, or a singleheat radiation fin 501 is provided (i.e., theheat radiation fins 501 are provided separately).
By forming such a structure, it is possible to improve the cooling effect in the vicinity of the bottom 500 of the reagent reservoir tank 200 (a lower region in the height direction of the side surface of the reagent reservoir tank 200) and to maintain the uniformity of cooling by suppressing temperature rise.
(tenth embodiment)
Fig. 13 is a schematic view showing the arrangement of a catheter on a reagent cartridge cover according to a tenth embodiment of the present invention.
Theconduit 207 is disposed inside thereagent reservoir cover 202, theconduit 207 may be disposed in a circular configuration as a whole, and theconduit 207 has a plurality of conduit layers radially distributed from the outer periphery to the center of thereagent reservoir cover 202, wherein theconduit 207 on thereagent reservoir cover 202 may be disposed simultaneously with theconduit 207 on the side surface of the reagent reservoir well and the bottom of the reagent reservoir well (may be disposed in any one of the first to ninth embodiments), or may be disposed independently (theconduit 207 is disposed only on the reagent reservoir cover 202).
Since dew is formed on the surface of theconduit 207, theconduit 207 is not disposed at a position above the opening of thereagent container 6 in order to prevent the dew from falling into thereagent container 6.
(eleventh embodiment)
FIG. 11 is a view showing the direction A-A of the first reagent kit in FIG. 1 according to the eleventh embodiment of the present invention.
Since there is a place where the sealing or heat insulation is insufficient (i.e., a place where the temperature is susceptible to external factors) inside thereagent reservoir tank 200, for example, the wiring between the outside and the inside of thereagent reservoir tank 200 and the throughhole 301 for the sensor are formed on the side surface of thereagent reservoir tank 200, the air inside thereagent reservoir tank 200 may contact with the outside air through the throughhole 301, resulting in poor cold insulation near the throughhole 301. For another example, the cooling effect is also relatively poor in the vicinity of thedrain port 502 and thetransmission part 503 at the bottom of thereagent reservoir tank 200.
Therefore, thefan 308 and the temperature sensor are disposed inside the reagent reservoir tank, and both thefan 308 and the temperature sensor are disposed near the positions (such as the throughhole 301, thedrain opening 502, and the transmission part 503) on the inner wall of the reagent reservoir tank where the temperature is susceptible to the external factors, so that the local temperature reduction is achieved by increasing the wind speed to improve the heat exchange efficiency.
The present embodiment also generally includes a control component, and the control component may be theanalysis control part 2 of the automatic analysis device, when the temperature sensor detects that the temperature of the high risk position is higher than the set standard value, the control component starts thefan 308 of the high risk position to realize cooling, and when the temperature sensor detects that the temperature of the high risk position is not higher than the set standard value, thefan 308 is turned off or the rotation speed of thefan 308 is reduced.
While several embodiments of the present invention have been described, these embodiments have been presented by way of example only, and are not intended to limit the scope of the invention. These new embodiments can be implemented in other various ways, and various omissions, substitutions, combinations, and changes can be made without departing from the spirit of the invention. These embodiments and modifications are included in the scope and gist of the present invention, and are included in the present invention and the equivalent scope thereof described in the claims.
Claims (34)
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| JP2020180771AJP2021067694A (en) | 2019-10-28 | 2020-10-28 | Reagent storage and automatic analyzer |
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