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CN112562832A - Human sperm library information management system and method - Google Patents

Human sperm library information management system and method
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CN112562832A
CN112562832ACN202011413844.0ACN202011413844ACN112562832ACN 112562832 ACN112562832 ACN 112562832ACN 202011413844 ACN202011413844 ACN 202011413844ACN 112562832 ACN112562832 ACN 112562832A
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semen
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CN112562832B (en
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岳焕勋
李福平
鲜泱
李定明
刘博�
蒋敏
蒋小辉
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West China Second University Hospital of Sichuan University
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West China Second University Hospital of Sichuan University
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Abstract

Translated fromChinese

本发明公开了人类精子库信息管理系统及方法,融合了供精管理系统和自存精管理系统及方法,实现了捐精志愿者从筛查、采集、检疫、外供到生殖中心用精反馈信息等过程,以及自存精者从检查、冷冻、生殖中心使用反馈等过程中关于数据采集、存储、管理和反馈的全流程管理,提高了工作人员对各项数据的有效管理,在其管理过程中,通过两套编号设置,能有效保证双盲原则,另外,结合现有身份识别系统(指纹识别),用于在注册和各阶段签到过程中进行唯一确认,同时,根据签到信息生成流程图,可供工作人员快速获取进度,除此之外,在管理过程中,还能做到信息的监控和预警,实现了人类精子库更加安全、合理、有效的管理。

Figure 202011413844

The invention discloses a human sperm bank information management system and method, which integrates a sperm donor management system and a self-storage sperm management system and method, and realizes the sperm donation volunteers from screening, collection, quarantine, external donation to the reproductive center using sperm feedback Information and other processes, as well as the whole process management of data collection, storage, management and feedback from the inspection, freezing, reproductive center use feedback and other processes of self-storage sperm, improve the effective management of various data by staff, and in their management In the process, through two sets of number settings, the double-blind principle can be effectively guaranteed. In addition, combined with the existing identification system (fingerprint identification), it is used for unique confirmation during the registration and check-in process at each stage. At the same time, the process is generated according to the check-in information. In addition, in the management process, information monitoring and early warning can also be achieved, realizing a safer, more reasonable and effective management of the human sperm bank.

Figure 202011413844

Description

Human sperm library information management system and method
Technical Field
The invention belongs to the technical field of medical information, and particularly relates to a human sperm bank information management system and method.
Background
The human sperm bank is a mechanism for collecting, detecting, storing and providing sperms by utilizing an ultralow temperature freezing technology, and aims to provide healthy and qualified frozen sperm supply for medical institutions legally developing sperm supply assisted reproduction technology and provide reproductive insurance for male patients in need. The daily work of the human sperm bank not only comprises the screening of healthy sperm-supplying volunteers, the collection, the freezing and the storage of the semen and the provision of safe, reliable and effective semen for sperm-using units, but also comprises a strict monitoring mechanism so as to ensure that the semen sample of each sperm-supplying person can only enable 5 women to be pregnant at most. In addition, the sperm bank can provide fertility preservation services for male patients with fertility preservation requirements, such as tumor patients, ART backup, dichotomy, disease treatment, and the like. In order to promote the human sperm bank to safely, effectively and reasonably collect, store and provide sperms and ensure the health and rights and interests of individuals, families and offspring of sperm suppliers/self-preserved sperms and recipients, the human sperm bank should establish the files of the sperm suppliers and the self-preserved sperms, and carry out computer management and permanent storage on the detailed information of the sperm suppliers and the self-preserved sperms and the use condition of the sperms.
For example: the existing patent document CN1376995A (sperm library database management system, 2002.10.30) discloses a database management system supported by hardware and software of a computer, which establishes three database management systems meeting various management requirements, designs four tables after multiple experiments, and contains relevant data of a sperm library therein, the computer manages the tables, and an operator inquires desired information from the four tables, thereby realizing convenient, fast, and safe retrieval, statistics, update, report, inquiry and permanent storage of data of human sperm data. In the practical application process, it is found that although the existing fine data base can conveniently, quickly and safely retrieve, count, update, report and query human fine data through a computer, the existing fine data base lacks the process management and the management and feedback of external fine data at each stage in the fine data supply process due to the complexity of the fine data supply process and the increase of the external fine data supply quantity, and cannot fundamentally guarantee the management efficiency and the safety of the human fine data base.
On the basis, with the continuous development of modern information technology, more and more process management systems are applied to the management process of the human sperm library. For example, the prior patent document CN108288497A (human sperm library for sperm supply, sperm use follow-up information management system, 2018.07.17) discloses a management system consisting of a human sperm library end and a sperm use mechanism end, wherein the sperm use mechanism comprises an online application module and an online filling module; the human sperm library end comprises a human sperm library end personal work module, a sperm library management module and a follow-up visit management module; the online application module is used for initiating application related to sperm utilization to a human sperm library end; the human sperm library end personal workbench module is used for allowing workers to examine and approve the application; the semen library management module is used for the staff to perform semen use information management, semen supply management and semen distribution management; the online filling module is used for filling follow-up visit information records for workers and submitting the follow-up visit information records to a sperm bank for examination on line; and the follow-up management module is used for managing follow-up information records by workers. The technical problems that the follow-up process is long in time consumption and timely transmission and updating of data cannot be achieved in the prior art are solved. For another example, in an existing patent document CN1091448831A (sperm library information management system, 2019.03.08), the system uses a public client, a semen collection point client, a sperm client, a hospital client, and a collaborative medical information platform, so that a sperm supplier, a hospital doctor, a semen collection point worker, or a sperm library worker can query, update, and automatically discard the sperm library information through the collaborative medical information platform, thereby implementing effective management of the information in the sperm library, saving social labor cost, and improving efficiency of the hospital in developing artificial assisted reproductive service.
Disclosure of Invention
The invention aims to provide a human sperm bank information management system which can not only solve the effective management of various data in the sperm donation process by workers, but also protect the information of sperm donors through the arrangement of two sets of numbering modes of the ID numbers of the sperm donors and the serial numbers of the sperm donors by collecting, storing and managing the relevant information and data of the sperm donors in the processes of registration, screening, collection and quarantine, thereby realizing the double-blind principle with the reproductive center. Meanwhile, the invention also provides a method of the human sperm library information management system.
Another objective of the present invention is to provide a human sperm bank information management system, which not only can solve the problem of effective management of various data in the sperm donation process by the staff through the collection, storage and management of the relevant information and data of the sperm supplier in the processes of registration, examination and collection, but also can mark the frozen semen supplying liquid through the setting of the freezing label, so as to facilitate the checking with the reproductive center. Meanwhile, the invention also provides a method of the human sperm library information management system.
The invention is realized by the following technical scheme:
a human sperm library information management system comprising:
a registration module: the system is used for inputting the information of the sperm supplier and generating a corresponding sperm supplier ID number;
a screening module: managing the inspection data of the sperm supplier in the screening stage, obtaining qualified sperm suppliers, and generating sperm supplier numbers corresponding to the blood types of the sperm suppliers;
an acquisition module: carrying out at least two times of sample collection on a sperm supplier qualified by screening, inputting the detection result of the sample collected each time, simultaneously sending an instruction for inputting the sample collected each time into a collection tank to a worker through a processing module, and after the collection of all the samples is finished, sending an instruction for transferring all the samples in the collection tank to a quarantine tank to the worker through the processing module;
a quarantine module: managing the semen supplier entering the quarantine period, inputting the inspection result of HIV of the qualified semen supplier, and sending an instruction for transferring the sample corresponding to the semen supplier qualified in HIV inspection in the quarantine tank to an external supply tank to a worker by a processing module according to the inspection result;
a storage module: the system is used for storing the data of the registration module, the screening module, the acquisition module and the quarantine module.
The information of the sperm supplier comprises fingerprints, identity card information and personal basic information of the sperm supplier.
The screening stage comprises semen examination, physical examination and blood drawing examination of a semen donor, and the management of the examination data comprises the following steps:
(1) inputting semen inspection data and screening, screening qualified semen suppliers for physical examination, screening unqualified semen suppliers for taking samples again for semen inspection, inputting second semen inspection data and screening, screening qualified semen suppliers for physical examination;
(2) inputting physical examination data of sperm donors qualified in sperm examination, screening, and performing blood drawing examination on the qualified sperm donors;
(3) and (4) inputting blood drawing inspection data of sperm donors qualified in physical examination, screening, and collecting specimens of sperm donors qualified in screening.
The collection module further comprises a calculation submodule, the calculation submodule is used for generating the number of qualified samples which can be stored in a freezing mode according to the detection result of the collected samples at each time, and meanwhile, corresponding bar codes are generated, wherein the bar codes comprise numbers of the sperm supplier and numbers of each corresponding sample, and the bar codes are used for judging the time of next sample collection according to the detection result of the collected samples at the last time.
The collection module and the quarantine module respectively comprise a monitoring submodule, the monitoring submodule is used for managing the time from blood drawing examination to the completion of all specimen collection of a sperm supplier, and managing the time of a quarantine period, and the quarantine period is 180 days from the completion of all specimen collection.
Screening module, collection module and quarantine module all include the submodule of registering, and the submodule of registering is used for entering before screening stage at every inspection and supplies smart person's fingerprint information and generate corresponding information of registering for enter before every collection sample and generate corresponding information of registering to and enter when being used for carrying out the quarantine after the quarantine period finishes and supply smart person's fingerprint information and generate corresponding information of registering.
Further comprising:
the external supply management module: the system is used for managing the sample information, the information of a reproduction center and the fine feedback information in the external supply tank;
follow-up management module: the method is used for managing the follow-up visit information of the spermatophore.
A human sperm library information management system comprising:
a registration module: the system is used for inputting information and inspection data of a self sperm storing person and generating a corresponding label;
a freezing module: freezing the sample of the sperm self-storage person corresponding to the label, inputting the detection result of the frozen sample, sending an instruction for inputting the frozen sample into the self-storage tank to a worker through the processing module, and simultaneously obtaining a frozen label;
a storage module: the data of the registration module and the freezing module are stored.
The information of the self-preservation spermatozoa comprises a file number, a fingerprint, identity card information and personal basic information of the self-preservation spermatozoa.
The examination data includes data for semen examination and blood drawing examination of a person who is in self-storing semen.
The freezing label comprises the name, the identification number and the file number of the self-preservation sperm.
The freezing module further comprises a calculating submodule, the calculating submodule is used for generating the number of qualified specimens which can be frozen and stored according to the detection result of the frozen specimens at each time, and meanwhile, corresponding bar codes are generated, wherein the bar codes comprise the names, the file numbers, the identity card numbers and the numbers of the corresponding specimens of the self-preservation sperm.
The freezing module includes the submodule of registering, and the submodule of registering is used for typeeing the fingerprint information of preserving smart person before freezing the sample and generates corresponding information of registering.
The device also comprises a protocol module which is used for generating a frozen semen protocol and a frozen semen continuation protocol which can be signed by a self semen storage person.
The automatic semen storage device further comprises a monitoring module, wherein the monitoring module is used for managing the time from blood drawing examination to the completion of all sample collection of a self semen storage person, the storage time of the self-stored in-tank samples and the time limit of a semen freezing protocol and a semen freezing continuing protocol.
The self-refined sample delivery management module is used for managing sample information in the self-storage tank, information of a reproduction center and precision feedback information.
The human sperm library information management method comprises the following steps:
A. registering the sperm supplier, inputting the information of the sperm supplier and generating a corresponding ID number of the sperm supplier;
B. screening the sperm supplier to obtain qualified sperm supplier and generating the sperm supplier number corresponding to the blood type;
C. carrying out at least two times of sample collection on a sperm supplier qualified by screening, inputting the detection result of the sample collected each time, simultaneously sending an instruction for inputting the sample collected each time into a collection tank to a worker, and after all samples are collected, sending an instruction for transferring all samples in the collection tank to a quarantine tank to the worker;
D. and inputting a detection result of HIV of a qualified sperm supplier, and sending an instruction for transferring a sample corresponding to the qualified sperm supplier for HIV detection in the quarantine tank to an external supply tank to a worker according to the detection result.
The information of the sperm supplier comprises fingerprints, identity card information and personal basic information of the sperm supplier.
The screening comprises the following steps:
(1) inputting semen inspection data and screening, screening qualified semen suppliers for physical examination, screening unqualified semen suppliers for taking samples again for semen inspection, inputting second semen inspection data and screening, screening qualified semen suppliers for physical examination;
(2) inputting physical examination data of sperm donors qualified in sperm examination, screening, and performing blood drawing examination on the qualified sperm donors;
(3) and (4) inputting blood drawing inspection data of sperm donors qualified in physical examination, screening, and collecting specimens of sperm donors qualified in screening.
In the step C, according to the detection result of the collected specimen at each time, generating the number of qualified specimens which can be stored in a frozen mode, and simultaneously generating corresponding bar codes, wherein the bar codes comprise the number of the sperm supplier and the number corresponding to each specimen; and judging the time for collecting the sample next time according to the detection result of the sample collected last time.
In the step B and the step C, the time from the blood drawing examination of the semen supplier to the completion of the collection of all samples is monitored; and D, monitoring the time of a quarantine period, wherein the quarantine period is 180 days from the time of finishing all the specimen collection.
In the step B, fingerprint information of a sperm supplier is input before each check in the screening process, and corresponding sign-in information is generated; in the step C, inputting fingerprint information of a sperm supplier before collecting the specimen each time and generating corresponding sign-in information; and D, inputting fingerprint information of the sperm supplier and generating corresponding sign-in information when the quarantine is carried out after the quarantine period is finished.
Further comprising the steps of:
E. managing the sample information in the external supply tank, the information of the reproductive center and the fine feedback information;
F. and managing the follow-up information of the sperm supplier.
The human sperm library information management method comprises the following steps:
A. registering the self-preservation sperm, inputting the information and the inspection data of the self-preservation sperm, and generating a corresponding label;
B. and (3) freezing the sample of the sperm self-storage person corresponding to the label, inputting the detection result of the frozen sample, sending an instruction for inputting the frozen sample into the self-storage tank to a worker, and simultaneously obtaining the frozen label.
The information of the self-preservation spermatozoa comprises a file number, a fingerprint, identity card information and personal basic information of the self-preservation spermatozoa.
The examination data includes data for semen examination and blood drawing examination of a person who is in self-storing semen.
The freezing label comprises the name, the identification number and the file number of the self-preservation sperm.
And in the step B, generating the number of qualified samples which can be stored in a frozen mode according to the detection result of the frozen samples at each time, and generating corresponding bar codes at the same time, wherein the bar codes comprise the name, the file number, the identification number and the number of each sample corresponding to the self-preservation person.
Fingerprint information of a self sperm-preserving person is input before the frozen specimen is obtained, and corresponding sign-in information is generated.
In the step A, when the self semen preserving person registers, a semen freezing protocol which can be signed by the self semen preserving person is generated.
In the steps A and B, the time from the blood drawing examination of the sperm storage person to the completion of the freezing of all the samples is monitored, the storage time of the samples in the self-storage tank is monitored, and the term of the protocol of the frozen sperm is monitored.
Further comprising the steps of:
C. the specimen information in the self-storage tank, the information of the reproduction center and the precision feedback information are managed.
Compared with the prior art, the invention has the following advantages and beneficial effects:
(1) the invention realizes the full-flow management of data acquisition, storage, management and feedback in the processes of screening, acquisition, quarantine, external supply to the reproductive center for the sperm feedback information and the like of the sperm donator, also realizes the full-flow management of data acquisition, storage, management and feedback in the processes of examination, freezing, reproductive center use feedback and the like of the sperm self-storing person, improves the management efficiency of workers on various data in the processes of sperm donation and sperm self-storing, and also makes contribution to safer, more reasonable and more effective operation of a human sperm bank.
(2) The invention provides two sets of numbering modes aiming at sperm donors, namely a sperm supplier ID number and a sperm supplier number, wherein the sperm supplier ID number is used for being issued to all registered donation sperm volunteers, and the sperm supplier number is only issued to the donation sperm volunteers qualified in screening. The two functions are different, in order to ensure the double-blind principle of the supplying and receiving parties and facilitate system management, the ID number of the sperm supplier is the number provided for the sperm bank to the volunteer (the volunteer does not know the ID number of the sperm supplier per se), the ID number of the sperm supplier is the number provided for the sperm bank to the auxiliary reproductive center (the reproductive center and the receiving party do not know the ID number of the sperm supplier), and two sets of numbers are adopted for management to ensure the double-blind principle.
(3) The invention needs to input the fingerprint and/or compare the fingerprint when the sperm supplier/self-preservation sperm bank carries out any step of operation each time the sperm supplier/self-preservation sperm bank comes, on one hand, the identity of the sperm supplier/self-preservation sperm can be rapidly confirmed, on the other hand, because the flow chart of the sperm supplier/self-preservation sperm can appear when the fingerprint is input/compared each time, and the corresponding sign-in information is generated at the same time, the invention is convenient for the working personnel to rapidly know the current stage of the sperm supplier/self-preservation sperm according to the flow chart of the sperm supplier/self-preservation sperm so as to carry out the next working arrangement. In the actual management process, the record of the check-in information is particularly convenient for a worker to inform a spermatophore of the next process of different stages in the process of collecting the specimens for multiple times.
(4) The invention also provides the management of the sperm library on the used sperm feedback information, and mainly aims at the problems that when the sperm utilization information fed back by the reproduction center is processed by the conventional sperm library management system, a safe and effective management mode is lacked, feedback information is still manually input, and information input errors are easily caused, so that the function of importing the feedback information is added. In the actual use process, when the semen sample is sent to the reproduction center by external supply sample management, a feedback table template which can be filled by the reproduction center is generated at the same time, the reproduction center fills in the table and feeds back the table, and the semen library directly imports the table fed back by the reproduction center into the management system after receiving the table, so that the feedback information can be rapidly input, and the error of manual input of the feedback information is avoided.
(5) The invention sets a monitoring (sub) module for monitoring data such as time range, sample use condition and the like required by a specific stage in the process management process, for example: in the external supply management process, the monitoring of the use condition of the specimen in the external supply feedback information comprises issued unused specimens, overdue feedback specimens, single-use specimens and the like, so that problems can be found in time, and a warning effect is achieved; in the self semen storing process, the method can be used for monitoring the semen freezing protocol time limit so as to feed back to the staff for reminding; in the fine feeding process, the method can be used for monitoring quarantine period and the like.
(6) The invention can realize the storage of various data of a spermatophore in the stages of registration, screening, collection and quarantine or self-preservation spermatophore in the stages of registration and collection through the storage module, can realize the report counting function through the processing of the processing module, generates key data of the spermatophore/self-preservation spermatophore by one key, and is convenient for the operation and management of workers. For example, an external supply delivery list can be generated, and a worker can quickly search the position of a specimen in the external supply tank or the self-supply tank according to the number of a sperm supplier listed in the external supply delivery list or the data such as a freezing label of a sperm self-storage person; generating various statistical reports containing the data of the sperm supplier and the sperm self-storing supplier, wherein the statistical reports can be divided into monthly reports, quarterly reports and annual reports; and generating reports of data of each stage of the spermatozoa supplier or the spermatozoa self-depositor, printing and exporting, conveniently managing key data of the sperm bank, and the like.
(7) In the self-preservation sperm management process, the frozen specimen can be effectively preserved for a long time or permanently, and the fingerprint is adopted for identity recognition during the preservation process, so that the condition that the identity of a patient cannot be recognized due to various certificate changes, appearance changes or other factors which may change within the preservation period can be avoided.
In summary, the invention constructs a system capable of realizing full-flow information management according to the existing human sperm bank management method, improves the safety and the high efficiency of the existing human sperm bank information management, sets two sets of numbers to be respectively issued in the system, and ensures a double-blind principle.
Drawings
FIG. 1 is a flow chart of a sperm supplier according to the present invention.
FIG. 2 is a system architecture diagram of the present invention.
Detailed Description
The present invention will be described in further detail with reference to examples, but the embodiments of the present invention are not limited thereto.
Example 1:
the present embodiments relate to a human sperm cell library management system and method. The intelligent person management system comprises a registration module, a screening module, an acquisition module, a quarantine module, an external supply management module, a follow-up management module, a storage module, a processing module and the like, and provides full-process management of acquisition, storage, management and feedback of relevant data of an intelligent person in the processes of screening, acquisition, quarantine, external supply to a reproductive center information and the like.
The registration module is used for the spermatozoa to register, and after the spermatozoa inputs the fingerprint, the identity card information and the personal basic information (including occupation, academic calendar, contact way, physical and morphological characteristics, interests, hobbies, information source ways and the like) of the spermatozoa, the registration is completed, and meanwhile, the spermatozoa obtains the corresponding ID number of the spermatozoa. The sperm supplier ID number is simply the number provided to the sperm supplier by the sperm library.
The screening module is used in a screening stage, the screening stage refers to the process of semen examination, physical examination and blood drawing examination of the sperm supplier who is successfully registered, and meanwhile, a sperm supplier number corresponding to the blood type of the sperm supplier is generated, and the sperm supplier number is only a number provided for a reproductive center by a sperm bank. The sperm supplier does not know the serial number of the sperm supplier, and the reproductive center does not know the ID number of the sperm supplier, thereby ensuring the double-blind principle.
The screening module also comprises a check-in submodule which is mainly used for managing various inspection data of a sperm supplier in a screening stage, and the management steps are as follows:
(1) inputting fingerprints by a sperm supplier, generating corresponding check-in information for one time, inputting sperm inspection data (mainly comprising abstinence time, volume, stock solution concentration, stock solution vitality, cells, concentration after resuscitation, vitality after resuscitation, resuscitation rate, microorganism culture of sperm, including mycoplasma, chlamydia, aerobic bacteria, gonococcus and the like) of the sperm supplier after the sperm supplier takes a sample and performs sperm inspection, screening to obtain qualified screened sperm suppliers and unqualified sperm suppliers, editing the contents of the qualified sperm supplier for physical examination and the unqualified sperm supplier for the sperm inspection again into system information notification by a processing module, notifying the sperm supplier to perform the next process according to the system information by a worker, inputting second sperm inspection data for screening to obtain qualified screened sperm suppliers and unqualified suppliers, the processing module respectively edits the contents of the qualified screeners for physical examination and the rejected screeners for disqualification into system information notification, and the staff notifies the screeners to carry out the next process according to the system information.
(2) The semen supplier qualified in semen inspection inputs the fingerprint and generates corresponding sign-in information once, after the semen supplier performs physical examination, physical examination data (including the past medical history, personal life history, sexual propagation disease history, family investigation, physical examination and the like of a patient) of the semen supplier is input and screened to obtain semen suppliers qualified in screening and unqualified in screening, the processing module edits the semen supplier qualified in screening into system information notification respectively through blood drawing examination and the semen supplier eliminated content unqualified in screening into system information notification, and the working personnel inform the semen supplier to perform the next process according to the system information.
(3) The semen supplier qualified in physical examination inputs the fingerprint and generates corresponding sign-in information once, after the semen supplier performs blood drawing examination, the blood drawing examination data (including blood type, blood routine, hepatitis B, hepatitis C, syphilis, AIDS, TORCH, chromosomes and the like) of the semen supplier is input and screened to obtain qualified screened semen suppliers and unqualified screened semen suppliers, the processing module respectively edits the contents of specimen collection of the qualified semen supplier and elimination of the unqualified semen supplier into system information notification, and the working personnel inform the semen supplier to perform the next process according to the system information.
The collection module is used for the collection stage to use, needs to carry out sample collection many times to the qualified confession essence person of screening, and collection module still includes the submodule of registering, calculates submodule and control submodule, and main work flow is as follows:
(1) the semen supplier qualified in blood drawing examination inputs a fingerprint and generates corresponding check-in information once, after the semen supplier collects a first sample, a detection result (including abstinence time, volume stock solution concentration, stock solution activity, cells, concentration after resuscitation, activity after resuscitation, resuscitation rate, semen microorganism culture and other data) collected by the first sample is input, the calculation submodule calculates the qualified count capable of being stored in a freezing mode according to the detection result, and generates a corresponding bar code simultaneously, wherein the bar code comprises the semen supplier number and the number corresponding to each sample, such as A2020001-1, and the bar code is pasted on a freezing pipe of the frozen sample semen. Meanwhile, the calculation submodule judges the time for collecting the sample next time according to the detection result, sends the time to the processing module, and then sends an instruction for inputting the sample collected each time into the collection tank to the staff.
(2) And B, inputting the fingerprint for the second time by the spermatophore, generating corresponding sign-in information once, inputting the detection result of the second time of sample acquisition after the spermatophore is subjected to the second time of sample acquisition, and repeating the operation of the step A by the calculation submodule.
(3) And after the collection of all the samples is finished, completing the collection stage, and sending an instruction for transferring all the samples in the collection tank to the quarantine tank to a worker through the processing module.
The quarantine module is used in a quarantine stage, enters the quarantine stage when the last collection is finished, performs HIV inspection on qualified sperm feeders after the quarantine period of the quarantine stage is finished, inputs the inspection result of HIV and performs screening to obtain qualified sperm feeders and unqualified sperm feeders, the processing module respectively transfers samples corresponding to the qualified sperm feeders to an external supply tank and edits eliminated contents of the unqualified sperm feeders into system information notification, and the working personnel notify the sperm feeders to perform the next process according to the system information. The quarantine period is 180 days from the time when all samples are collected, and when the sperm bank is quarantined after the quarantine period is finished, the sperm is input with the fingerprint and corresponding check-in information is generated.
In this embodiment, the collection module and the quarantine module each include a monitoring submodule, the monitoring submodule is used for managing the time from the blood drawing examination of the semen supplier to the completion of the collection of all the specimens to be at least 6 months, and managing the time of the quarantine period, before expiration, the monitoring submodule sends expiration information to the processing module, and the processing module sends a reminding notice to the staff.
The screening module, collection module and quarantine module all include the submodule of registering for input the fingerprint and/or carry out the fingerprint and compare before supplying smart person to come the sperm storehouse at every turn and carry out any one operation, not only can confirm fast supplying smart person's identity, can also generate the information of registering that once corresponds, simultaneously under processing module's processing, provide this supply smart person's flow chart when inputting the fingerprint at every turn/comparing the fingerprint, as shown in figure 1, make things convenient for the staff to know fast according to supplying smart flow chart and supply smart person present stage, in order to carry out the work arrangement on next step.
The external supply management module is used for external supply jar interior sample information, with the information of smart mechanism and with the management of smart feedback information, and specific content includes:
management of specimen information: the method specifically comprises the management of the distribution use, the distribution amount, the inventory allowance and the position of the specimen in the external supply tank. In the specimen management process, according to the specimen collection count and the stock, the specimen is divided into 3 pieces of intended sending purposes in advance through the processing module, and the samples are marked, such as AID: for insemination artificial insemination, IVF: for fine IVF, special specimens: the specimens/minority ethnic minority specimens/Rh negative blood specimens/second fetus specimens which are detected by special genes belong to relatively rare specimens and are classified separately, and special patients need to apply for the specimens separately and issue the specimens separately.
According to the file of the department of health 176, the sperm bank also distributes the samples of the sperm-providing volunteers in a descending manner according to the feedback information of the reproductive center so as to strictly control the conception of 5 women. Therefore, the amount of the samples in the external supply tank needs to be automatically calculated by the calculation submodule of the external supply management module according to the sample distribution condition and the reproduction center feedback information. On the management system, the processing module can be used to display different background colors according to the number of the currently dispensable specimens, such as: the disposable specimen has no special background color of more than 0, and can be dispensed in a descending manner; the pregnant 5 who can not release the specimen is displayed in yellow and can not release the specimen temporarily; the 5 people who have been born alive are displayed in red (the specimen of the 5 people who have been born alive can not be released any more, and needs to enter the supply stop stage in time), so that the working personnel can conveniently check the specimens in different states according to different background colors.
Information management with fine organization: the method specifically comprises the steps of judging whether the registration time of a fine organization, the contract expiration time and the batch text time of assisted reproduction meet the qualification.
Management with fine feedback information: the method is mainly characterized in that a sperm library manages sperm feedback information for a reproduction center, when a sperm sample is issued to the reproduction center in an external supply stage, a feedback form template (including a sperm supplier number, a sample number, an issuing date, a user medical record number, a use ending and the like) which can be filled in by the reproduction center is generated at the same time, the reproduction center fills in the form and feeds back, and the sperm library directly imports a management system after receiving a form fed back by the reproduction center, so that the feedback information can be quickly input, and errors in manual input of the feedback information are avoided.
In addition, the external supply management module also comprises a monitoring submodule for monitoring external supply feedback information, wherein the monitored data comprises a dispensed unused sample, an overdue feedback sample, a single-use sample and the like, and the monitoring submodule can be used for monitoring the use and feedback conditions of sperm in the sperm feedback information of the reproduction center by a sperm bank, finds problems in time and plays a role in warning; the method is used for monitoring and counting information of external supply distribution, and the data to be monitored comprises purposes, blood types, total quantity, external supply units, external supply time and the like, so that the sperm bank can monitor the external supply sperm condition.
According to the processes of registration, screening, collection, quarantine, external supply and the like of sperm suppliers in a human sperm bank, the embodiment is respectively provided with a registration module, a screening module, a collection module, a quarantine module and an external supply management module for effective management, and in the actual working process, the embodiment also relates to the signing of a sperm supply protocol, so the embodiment also comprises a protocol module; the device also relates to the collection of follow-up information of the sperm supplier, so that the device also comprises a follow-up module; in order to facilitate the searching and effective management of the storage position of the specimen in the tank, the system also comprises an inventory management module.
The protocol module is used for generating a semen presentation protocol after the semen supplier is screened to be qualified, and then carrying out subsequent acquisition stage flow after the semen supplier needs to sign the semen presentation protocol.
The follow-up module is used for managing the follow-up information of the semen supplier, and comprises the steps of recording the follow-up record of the volunteer during the first specimen collection and the follow-up record of the semen supplier in the quarantine period, wherein the follow-up contents comprise the conditions of no urinary tract genital tract infection, the existence of new sexual partners, the existence of other abnormal conditions and the like.
The inventory management module is used for managing the types (collection tank, quarantine tank and external supply tank) and inventory capacity (usage amount and surplus) of the existing liquid nitrogen tank, can conveniently find the position of the specimen, and can immediately find the storage position of the specimen if the ID number or the serial number of the sperm supplier is adopted, so that the work efficiency of the sperm bank is improved.
The storage module is used for storing various data of the registration module, the screening module, the acquisition module, the quarantine module, the external supply management module, the follow-up module and the inventory management module. The data storage of the essence supplier in each stage of registration, screening, collection, quarantine and the like can be realized, the report counting function can be realized through the processing of the processing module, the key data of the essence supplier can be generated by one key, and the operation and the management of workers are facilitated. For example: data reports of data of the sperm supplier in each stage can be generated, such as a physical examination report, a blood drawing examination report and the like; various statistical reports containing semen donator data can be generated, and the conditions of semen donation volunteers, such as monthly reports, quarterly reports, annual reports and the like, can be comprehensively counted; can generate the outer supply delivery list, the staff provides the data such as smart person's serial number according to the outer supply delivery list, seeks the position of the interior sample of outer supply jar fast.
The processing module is also provided with a file management module, and the sperm bank stores paper files and uniformly prints, manages, files and scans electronic versions of the files (registration, screening, collection, quarantine, follow-up visit, stock positions, issuing conditions and feedback conditions) generated in each stage through the file management module.
In the process of managing the sperm bank, an authority management module is also arranged, different authorities are arranged for workers at different posts according to the authority management module, a department leader/manager has all the authorities, different authorities are distributed for different posts such as a reception post, a laboratory post, a file management post and the like, the information safety is further ensured, and the effective operation of the sperm bank is maintained.
Example 2:
the present embodiment relates to a human sperm bank management system and method, and it is known that another task of a sperm bank can provide fertility preservation service for men who need fertility preservation, and therefore, the human sperm bank management system according to the present embodiment includes the functions described inembodiment 1, and further provides a self semen preservation management system capable of providing fertility preservation service for self semen preservation people, and the system mainly includes a registration module, a freezing module, a storage module, and a self semen sample ex-warehouse module. In the actual management process, referring to the system architecture diagram shown in fig. 2, a computer system is used for management, and different management terminals are set according to different working contents and positions, so as to realize effective management of the human sperm library.
In the self-preserved semen management system according to this embodiment, the registration module is used when the self-preserved semen person registers, and when the self-preserved semen person enters the profile number, fingerprint, identification card information, and personal basic information (including basic information of the patient, freezing reason, specimen type (including semen and testicular tissue), freezing mode, freezing time, etc.) and pre-freezing examination results (taking the specimen to perform semen examination and blood drawing examination, and obtaining examination data of hepatitis b, hepatitis c, syphilis, HIV, mycoplasma, chlamydia, aerobic bacteria, gonococcus culture), the registration is completed, and at the same time, the self-preserved semen person obtains a corresponding label.
The freezing module is used for the patient to carry out the sample freezing stage and uses, need carry out the sample freezing to the person of preserving sperm oneself, and the freezing module still includes calculation submodule and the submodule of registering, and the freezing module is the same with the main work flow who supplies collection module among the sperm management system inembodiment 1, includes following step:
(1) the method comprises the steps that a sperm self-storing person inputs fingerprints, corresponding sign-in information is generated once, after the sperm self-storing person freezes a first specimen, a detection result (including abstinence time, volume stock solution concentration, stock solution vitality, cells, concentration after resuscitation, vitality after resuscitation, resuscitation rate, sperm culture and other data) of the first specimen is input, a calculation sub-module calculates the qualified count capable of being frozen and stored according to the detection result, and meanwhile, a corresponding bar code is generated and comprises the name, the identity card number, the file number and the number corresponding to each specimen, such as G0001-1, Zhang III, 51011111111111111. Is stuck on a freezing tube for freezing the semen sample. And simultaneously, sending an instruction for recording the frozen samples into the freezing tank for each time to a working person to the processing module. The number of times of specimen freezing is selected by the patient, if the patient selects multiple times of freezing, the calculation submodule judges the next time of specimen freezing according to the detection result, the time is sent to the processing module, and then the processing module sends an instruction for recording the specimen collected each time into the self-storage tank to the staff.
(2) And (3) inputting the fingerprint for the second time by the self-preservation sperm, generating corresponding sign-in information for the first time, inputting the detection result of the second time sample after the self-preservation sperm is frozen, and repeating the operation of the step (1) by the calculation submodule.
(3) And after the semen self-storing person finishes freezing all the specimens, simultaneously obtaining a freezing label and a semen freezing protocol.
The freezing label comprises the name, the identification number and the file number of the person who stores the sperm, and is convenient for checking the sperm bank workers when the sperm bank workers leave the warehouse and checking the sperm bank workers when the reproductive center is used.
The protocol submodule is used for generating a semen freezing protocol which can be signed by a semen self-storing person and a semen freezing continuing protocol of the semen self-storing person, and the semen freezing protocol and the semen continuing protocol can be signed after being printed. The frozen semen agreement has a certain period, after the expiration of the period of the agreement, the patient is informed of carrying out a renewal operation after the renewal (the agreement is terminated if the patient chooses not to renew the fee), the frozen semen renewal agreement which can be signed by the self-deposited semen is generated again, the period of the agreement is monitored by the monitoring module, before the expiry, the monitoring module sends expiry information to the processing module, and the processing module sends a notice of reminding the self-deposited semen to renew the fee to the staff. In addition, the monitoring module is also used for managing the time from blood drawing examination to the completion of all sample freezing of the semen supplier to be at least 6 months, and managing the storage time of the samples in the self-storage tank, before expiration, the monitoring module sends expiration information to the processing module, and the processing module sends a reminding notice to a worker.
The self-semen sample delivery module is used for managing sample information, information of a reproductive center and semen use feedback information in the self-preservation tank, the specific management flow is the same as that of the semen supplier management system in theembodiment 1, and the use of the sample is only limited to the use of a self-semen supplier.
It should be noted that the self-preservation sperm management system can realize the long-term or permanent effective preservation of the frozen specimen, and during the preservation period, the fingerprint is adopted for identity recognition, so that the condition that the identity of the patient can not be recognized due to various certificate changes, appearance changes or other possible changing factors in the preservation period can be avoided.
The above description is only a preferred embodiment of the present invention, and is not intended to limit the present invention in any way, and all simple modifications and equivalent variations of the above embodiments according to the technical spirit of the present invention are included in the scope of the present invention.

Claims (8)

Translated fromChinese
1.人类精子库信息管理系统,其特征在于:包括:1. A human sperm bank information management system, characterized in that: comprising:注册模块:用于录入供精者的信息并生成对应的供精者ID号,所述供精者的信息包括指纹、身份证信息和供精者的个人基本信息;Registration module: used to input the information of the sperm donor and generate the corresponding sperm donor ID number, the information of the sperm donor includes fingerprints, ID information and the basic personal information of the sperm donor;筛查模块:对供精者在筛查阶段的检查数据进行管理并获得筛查合格的供精者,同时生成与之血型相对应的供精者编号;Screening module: manage the inspection data of the donors in the screening stage, obtain the qualified donors, and generate the donor number corresponding to their blood type;采集模块:对筛查合格的供精者进行至少两次标本采集,录入每次采集的标本的检测结果,同时通过处理模块向工作人员发送将每次采集的标本录入采集罐的指令,待全部标本采集完成后,通过处理模块向工作人员发送将采集罐内所有标本转移至检疫罐的指令;Collection module: Collect at least two specimens from the qualified sperm donors, and enter the test results of the specimens collected each time. At the same time, the processing module sends instructions to the staff to enter the specimens collected each time into the collection tank. After the specimen collection is completed, send an instruction to the staff to transfer all the specimens in the collection tank to the quarantine tank through the processing module;检疫模块:对进入检疫期的供精者进行管理,录入合格的供精者进行HIV的检查结果,由处理模块根据检查结果向工作人员发送将检疫罐内HIV检查合格的供精者所对应的标本转移至外供罐的指令;Quarantine module: Manage the sperm donors who enter the quarantine period, enter the HIV test results of the qualified sperm donors, and the processing module will send the staff the corresponding HIV test results in the quarantine tank according to the inspection results. Instructions for the transfer of specimens to external supply tanks;存储模块:用于对注册模块、筛查模块、采集模块、检疫模块的数据进行存储;Storage module: used to store the data of registration module, screening module, acquisition module and quarantine module;外供管理模块:用于对外供罐内的标本信息、生殖中心的信息以及用精反馈信息的管理;External supply management module: used for the management of specimen information in external supply tanks, reproductive center information, and sperm feedback information;随访管理模块:用于对供精者随访信息的管理。Follow-up management module: used to manage the follow-up information of sperm donors.2.根据权利要求1所述的人类精子库信息管理系统,其特征在于:所述筛查阶段包括对供精者进行精液检查、体格检查和抽血检查,对检查数据的管理包括以下步骤:2. The human sperm bank information management system according to claim 1, is characterized in that: the screening stage comprises carrying out semen examination, physical examination and blood examination to the sperm donor, and the management of examination data comprises the following steps:(1)录入精液检查数据并进行筛选,筛选合格的供精者进行体格检查,筛选不合格的供精者再次取标本进行精液检查,录入第二次精液检查数据并进行筛选,筛选合格的供精者进行体格检查;(1) Enter semen inspection data and conduct screening, screen qualified donors for physical examination, and screen unqualified donors to take samples again for semen inspection, enter the second semen inspection data and conduct screening, and screen qualified donors. Physical examination of spermatozoa;(2)录入精液检查合格的供精者的体格检查数据并进行筛选,筛选合格的供精者进行抽血检查;(2) Enter the physical examination data of the sperm donors who have passed the semen examination and screen them, and screen the qualified sperm donors for blood test;(3)录入体格检查合格的供精者的抽血检查数据并进行筛选,筛选合格的供精者进行标本采集。(3) Input the blood test data of the sperm donors who have passed the physical examination and screen them, and select the qualified sperm donors for sample collection.3.根据权利要求2所述的人类精子库信息管理系统,其特征在于:3. The human sperm bank information management system according to claim 2, wherein:所述采集模块还包括计算子模块,计算子模块用于根据每次采集的标本的检测结果,生成可以冷冻保存的合格标本支数,同时生成相应条码,所述条码包括供精者编号和对应每支标本的编号,以及用于根据上一次采集的标本的检测结果,判断下一次进行标本采集的时间;The collection module also includes a calculation sub-module, which is used to generate the number of qualified specimens that can be cryopreserved according to the detection results of the specimens collected each time, and generate corresponding barcodes at the same time, and the barcodes include the sperm donor number and the corresponding number. The serial number of each specimen, and it is used to judge the time of the next specimen collection based on the test results of the specimen collected last time;所述采集模块和检疫模块均包括监控子模块,监控子模块用于管理供精者从抽血检查至全部标本采集完成之间的时间,以及用于管理检疫期的时间,所述检疫期为全部标本采集完成的时间起180天;Both the collection module and the quarantine module include a monitoring sub-module, and the monitoring sub-module is used to manage the time from the blood test of the sperm donor to the completion of the collection of all specimens, as well as the time for managing the quarantine period, and the quarantine period is: 180 days from the time when all specimens are collected;所述筛查模块、采集模块和检疫模块均包括签到子模块,签到子模块用于在筛查阶段每次检查前录入供精者的指纹信息并生成对应的签到信息,用于在每次采集标本前录入供精者的指纹信息并生成对应的签到信息,以及用于检疫期结束后进行检疫时录入供精者的指纹信息并生成对应的签到信息。The screening module, the collection module and the quarantine module all include a check-in sub-module, and the check-in sub-module is used to input the fingerprint information of the sperm donor before each inspection in the screening stage and generate corresponding check-in information, which is used for each collection. The fingerprint information of the sperm donor is entered before the specimen and the corresponding sign-in information is generated, and the fingerprint information of the sperm donor is entered and the corresponding sign-in information is generated when the quarantine period is over.4.人类精子库信息管理系统,其特征在于:包括:4. A human sperm bank information management system, characterized in that it comprises:登记模块:用于录入自存精者的信息和检查数据,并生成对应的标签,所述自存精者的信息包括档案号、指纹、身份证信息和自存精者的个人基本信息,所述检查数据包括对自存精者进行精液检查和抽血检查的数据;Registration module: used to input the information and inspection data of the self-storage person, and generate the corresponding label. The above-mentioned test data includes the data of semen test and blood test for self-deposited semen;冷冻模块:对标签对应的自存精者进行标本冷冻,录入冷冻的标本的检测结果,并通过处理模块向工作人员发送将冷冻的标本录入自存罐的指令,同时获得冷冻标签,所述冷冻标签包括自存精者的姓名、身份证号和档案号;Freezing module: Freeze the specimens of the self-storage sperm corresponding to the label, enter the test results of the frozen specimens, and send the instructions to the staff to enter the frozen specimens into the self-storage tank through the processing module, and obtain the freezing label at the same time. The label includes the name, ID number, and file number of the self-preserving semen;存储模块:用于对登记模块、冷冻模块的数据进行存储;Storage module: used to store the data of the registration module and the freezing module;自精标本出库管理模块,自精标本出库管理模块用于对自存罐内的标本信息、生殖中心的信息以及用精反馈信息的管理。Self-sperm specimen delivery management module, self-sperm specimen delivery management module is used to manage the specimen information in the self-storage tank, the information of the reproductive center and the feedback information of the sperm.5.根据权利要求4所述的人类精子库信息管理系统,其特征在于:所述冷冻模块还包括计算子模块和签到子模块,计算子模块用于根据每次冷冻的标本的检测结果,生成可以冷冻保存的合格标本支数,同时生成相应的条码,所述条码包括自存精者的姓名、档案号、身份证号和对应每支标本的编号;签到子模块用于在获取冷冻标本前录入自存精者的指纹信息并生成对应的签到信息。5. The human sperm bank information management system according to claim 4, wherein the freezing module further comprises a calculation sub-module and a check-in sub-module, and the calculation sub-module is used to generate The number of qualified specimens that can be cryopreserved, and corresponding barcodes are generated at the same time. The barcodes include the name, file number, ID number and number corresponding to each specimen of the self depositing sperm; the sign-in sub-module is used to obtain frozen specimens before obtaining frozen specimens. Enter the fingerprint information of the self-storage person and generate the corresponding sign-in information.6.根据权利要求4所述的人类精子库信息管理系统,其特征在于:还包括协议模块和监控模块,协议模块用于生成可供自存精者签署的冻精协议以及冻精续约协议;监控模块用于管理自存精者从抽血检查至全部标本采集完成之间的时间,用于管理自存罐内标本的存放时间,以及冻精协议和冻精续约协议的期限。6. The human sperm bank information management system according to claim 4 is characterized in that: it also comprises a protocol module and a monitoring module, and the protocol module is used to generate a frozen sperm agreement and a frozen sperm renewal agreement that can be signed by a self-sperm depositor ; The monitoring module is used to manage the time between the blood test and the collection of all specimens of the self-storage person, the storage time of the specimens in the self-storage tank, and the duration of the frozen semen agreement and the frozen semen renewal agreement.7.人类精子库信息管理方法,其特征在于:包括以下步骤:7. A method for managing human sperm bank information, comprising the following steps:A.对供精者进行注册,录入供精者的信息并生成对应的供精者ID号,所述供精者的信息包括指纹、身份证信息和供精者的个人基本信息;A. Register the sperm donor, enter the information of the sperm donor and generate the corresponding sperm donor ID number, the information of the sperm donor includes fingerprints, ID information and the basic personal information of the sperm donor;B.对供精者进行筛查并获得筛查合格的供精者,同时生成与之血型相对应的供精者编号;B. Screen the sperm donors and obtain qualified sperm donors, and generate the sperm donor number corresponding to their blood type;C.对筛查合格的供精者进行至少两次标本采集,录入每次采集的标本的检测结果,同时向工作人员发送将每次采集的标本录入采集罐的指令,待全部标本采集完成后,向工作人员发送将采集罐内所有标本转移至检疫罐的指令;C. Collect at least two specimens from the sperm donors who have passed the screening, enter the test results of the specimens collected each time, and send instructions to the staff to enter the specimens collected each time into the collection tank, after all specimens are collected. , and send instructions to the staff to transfer all the specimens in the collection tank to the quarantine tank;D.录入合格的供精者进行HIV的检查结果,再根据检测结果向工作人员发送将检疫罐内HIV检测合格的供精者所对应的标本转移至外供罐的指令;D. Enter the HIV test results of the qualified sperm donors, and then send the staff an instruction to transfer the specimens corresponding to the HIV test qualified sperm donors in the quarantine tank to the external supply tank according to the test results;E.对外供罐内的标本信息、生殖中心的信息以及用精反馈信息进行管理。E. Manage the specimen information in the external supply tank, the information of the reproductive center and the feedback information of the sperm.8.人类精子库信息管理方法,其特征在于:包括以下步骤:8. A method for managing human sperm bank information, comprising the following steps:A.对自存精者进行注册,录入自存精者的信息和检查数据,并生成对应的标签,所述自存精者的信息包括档案号、指纹、身份证信息和自存精者的个人基本信息,所述检查数据包括对自存精者进行精液检查和抽血检查的数据;A. Register the self-preserving semen, enter the information and inspection data of the self-preserving semen, and generate corresponding labels. The information of the self-preserving semen includes file number, fingerprint, ID card information and Basic personal information, the inspection data includes the data of semen inspection and blood test of self-saved semen;B.对标签对应的自存精者进行标本冷冻,录入冷冻的标本的检测结果,并向工作人员发送将冷冻的标本录入自存罐的指令,同时获得冷冻标签,所述冷冻标签包括自存精者的姓名、身份证号和档案号;B. Freeze the specimen of the self-storage sperm corresponding to the label, enter the test results of the frozen specimen, and send an instruction to the staff to enter the frozen specimen into the self-storage tank, and obtain a frozen label at the same time, and the frozen label includes the self-storage. The name, ID number and file number of the sperm;C.对自存罐内的标本信息、生殖中心的信息以及用精反馈信息进行管理。C. Manage the specimen information in the self-storage tank, the information of the reproductive center and the feedback information of the sperm.
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CN118506944A (en)*2024-07-162024-08-16力盟生命科技(深圳)有限公司Biological sample low-temperature preservation management method, system, equipment and storage medium

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