CN112378855A - Liquid injection and liquid suction device for measuring chamber - Google Patents

Abstract

The application relates to a measuring room annotates liquid and imbibition device includes: the bracket is fixed on a measuring chamber cover plate, a turntable is arranged in the measuring chamber, a plurality of reaction cup accommodating positions arranged along the circumferential direction of the turntable are arranged on the turntable, and the reaction cups can pass through a liquid injection position and a liquid suction position sequentially by driving the turntable to rotate through a driving piece; the needle assembly comprises a liquid suction needle, a liquid injection needle and a needle fixing plate, wherein the liquid suction needle and the liquid injection needle respectively penetrate through the measuring chamber cover plate and correspond to reaction cups on the liquid suction level and the liquid injection level; the driving assembly comprises a screw motor, a transmission screw, a screw nut fixedly connected to the needle fixing plate, a driving seat fixed on the needle fixing plate, a linear guide rail arranged on the support and a sliding block fixed on the driving seat, one end of the transmission screw is connected with an output shaft of the screw motor, and the other end of the transmission screw is connected with a measuring chamber cover plate through a bearing. The liquid injection and absorption device of the measuring chamber saves the testing time and realizes the dry-wet separation treatment of the waste liquid and the used reaction cup.

Description

Liquid injection and liquid suction device for measuring chamber

Technical Field

The application belongs to the technical field of medical equipment, especially, relate to a measuring room annotates liquid and imbibition device.

Background

Currently, the most commonly used diagnostic method in the medical field, in vitro diagnosis, refers to collecting body fluids, excretions, and secretions of a human body to perform chemical composition or chemical reaction analysis, so as to determine human body lesions, such as chemiluminescence immunoassay, molecular diagnostics, and the like, wherein the diagnostic methods all use automatic or semi-automatic instruments to sample and analyze samples and give diagnostic reports, and the instruments all have a functional unit, namely a detection unit (i.e., a measurement chamber).

On a full-automatic chemiluminescence apparatus, a measuring unit (namely a measuring chamber) is of a closed dark container structure, the luminous value of a sample can be measured through a precise photon counter, so that the concentration of a detected object is calculated, a certain buffer solution (exciting agent) needs to be injected before the sample to be detected is tested and is used for exciting the detected object to emit light, the buffer solution has acidity and alkalinity, needs to be accurately injected into a reaction cup, cannot avoid splashing during high-speed injection, and avoids instrument faults caused by corrosion of the structure in a closed cavity of the measuring chamber. In addition, the tested sample contains acid-base solution and sample, which has biological safety hazard, so the tested mixed waste liquid needs to be recovered and centralized for treatment, and the waste liquid and the used reaction cup need to be separated in a dry-wet manner.

The measuring device provided by the patent of my application (document No. CN107167427A) a single reaction cup luminescence measuring device can only carry out single reaction cup measurement, a starter and an activator are added into the reaction cup through a reagent adding pipe during measurement, a sealed bin door is opened after the measurement is finished, the reaction cup with waste liquid is taken out, and then the next test is carried out, so that when one reaction cup in a measuring chamber carries out measurement, other reaction cup stations are in a waiting state, and the testing speed of the instrument is greatly reduced; meanwhile, after the luminescence measurement is finished, the waste liquid and the used reaction cup are not respectively treated, so that the post-treatment cost and time are greatly improved.

Disclosure of Invention

The technical problem to be solved by the invention is as follows: in order to solve the defects of low testing speed of the measuring chamber and high post-treatment cost of the used reaction cup in the prior art, the liquid injection and absorption device of the measuring chamber is provided.

The technical scheme adopted by the invention for solving the technical problems is as follows:

the utility model provides a measuring chamber annotates liquid and imbibition device which characterized in that includes:

the bracket is fixed on a measuring chamber cover plate at the top of the measuring chamber, a rotary table is arranged in the measuring chamber, a plurality of reaction cup containing positions which are arranged along the circumferential direction of the rotary table and are used for containing reaction cups are arranged on the rotary table, and the reaction cups in the reaction cup containing positions can pass through a liquid injection position and a liquid absorption position sequentially by driving the rotary table to rotate through a driving piece;

the needle assembly comprises a liquid suction needle, a liquid injection needle and a needle fixing plate fixedly connected with the liquid suction needle and the liquid injection needle and positioned at the upper part of the measuring chamber cover plate, and the liquid suction needle and the liquid injection needle respectively penetrate through the measuring chamber cover plate and correspond to reaction cups on the liquid suction level and the liquid injection level;

drive assembly, including lead screw motor, transmission lead screw in on the transmission lead screw spiral drive link firmly lead screw nut on the needle fixed plate, be fixed in the drive seat on the needle fixed plate, set up on the support with the linear guide that transmission lead screw is parallel and be fixed in on the drive seat with linear guide complex slider, the output shaft of lead screw motor is connected to transmission lead screw one end, and the other end passes through the bearing and is connected with measurement chamber apron, can make through lead screw motor, transmission lead screw be fixed in the imbibition needle on the needle fixed plate, annotate the liquid needle and reciprocate to through needle fixed plate, drive seat drive slider along linear guide reciprocate.

Preferably, the needle point of the liquid suction needle and the needle point of the liquid injection needle have a certain height difference; preferably, the liquid injection and suction device of the measuring chamber further comprises a liquid injection needle sealing assembly and a liquid suction needle sealing assembly, and the liquid injection needle sealing assembly comprises: the sealing column cover plate, the first sealing plug and the sealing column are provided with through holes for the liquid injection needle to pass through, and the bottom of the sealing column is provided with an accommodating cavity with the diameter larger than the outer diameter of the liquid injection needle; the pipette needle seal assembly comprises: the second sealing plug is arranged in a groove in the top of the measuring chamber cover plate and connected with a sealing plug cover plate arranged on the measuring chamber cover plate, and a second O-shaped ring is arranged on the periphery of the second sealing plug, and the sealing plug cover plate and the second sealing plug are provided with through holes for the liquid suction needles to pass through.

Preferably, interference fit is adopted between the liquid injection needle and the first sealing plug, between the liquid suction needle and the second sealing plug, between the first O-shaped ring and the first sealing plug, and between the second O-shaped ring and the second sealing plug.

Preferably, the inner holes of the first sealing plug and the second sealing plug are in tapered hole structures, and the first sealing plug and the second sealing plug are preferably made of wear-resistant black plastics.

Preferably, constitute by roof, riser, base, the base is fixed in on the measuring chamber apron, and linear guide sets up on the riser.

Preferably, two limiting pins are arranged at the upper end and the lower end of the vertical plate and used for limiting the sliding block.

Preferably, the driving seat is provided with an optical coupler catch, and the vertical plate is provided with an optical coupler corresponding to the optical coupler catch; before the turntable rotates, the optical coupler separation blade and the optical coupler are induced, so that a signal is sent to a control system, and the resetting of the whole needle assembly is realized.

Preferably, the liquid suction needle is connected with a waste liquid pipe, and the waste liquid pipe is connected with a waste liquid pump; the liquid injection needle is connected with the liquid injection pipe, and the liquid injection pipe is connected with the liquid injection pump.

Preferably, a notch is formed in the needle tip of the liquid suction needle.

Preferably, the liquid injection needle has a tapered needle tip.

The invention has the beneficial effects that:

the liquid injection and absorption device of the measuring chamber can enable the reaction cups in the reaction cup containing position to sequentially pass through the liquid injection position and the liquid absorption position, namely, the reaction cups are positioned at the liquid injection position when rotating to the position below the liquid injection needle, and are positioned at the liquid absorption position when rotating to the position below the liquid absorption needle, and in the continuous test, when the former reaction cup is positioned at the waste absorption liquid position, the latter reaction cup is positioned at the liquid injection position, namely, waste absorption liquid and buffer solution (exciting agent) injection are carried out simultaneously, so that the test time is greatly saved; particularly, the liquid injection and absorption device has the functions of liquid injection and absorption, after buffer liquid (exciting agent) is injected to complete luminescence measurement, the reaction cup can be transferred to the next station (liquid absorption level) so as to directly discharge waste liquid of the reaction cup to the outside of the system for recycling and centralized treatment, and then the reaction cup is transferred to the next station (reaction cup taking and placing position) so as to take away the reaction cup without the waste liquid, so that the dry-wet separation treatment of the waste liquid and the used reaction cup is realized, and the automation degree is extremely high.

Drawings

The technical solution of the present application is further explained below with reference to the drawings and the embodiments.

FIG. 1 and FIG. 2 are schematic structural views of a liquid injection and absorption device of a measuring chamber according to an embodiment of the present invention;

FIG. 3 is a cross-sectional view of a liquid filling and aspirating apparatus of a measuring chamber according to an embodiment of the present application.

The reference numbers in the figures are: 1-bracket, 11-top plate, 12-vertical plate, 13-base, 2-driving component, 21-screw rod motor, 23-driving seat, 24-optical coupler baffle, 25-optical coupler, 26-sliding block, 27-limit pin, 28-transmission screw rod, 29-screw rod nut, 3-needle component, 31-needle fixing plate, 32-liquid suction needle, 33-liquid injection needle, 4-liquid injection needle sealing component, 41-first O-shaped ring, 42-first sealing plug, 43-sealing column cover plate, 44-sealing column, 5-liquid suction needle sealing component, 51-sealing plug cover plate, 52-second sealing plug, 53-second O-shaped ring, 6-reaction cup, 7-rotary table and 8-measuring chamber cover plate.

Detailed Description

It should be noted that the embodiments and features of the embodiments in the present application may be combined with each other without conflict.

In the description of the present application, it is to be understood that the terms "center," "longitudinal," "lateral," "upper," "lower," "front," "rear," "left," "right," "vertical," "horizontal," "top," "bottom," "inner," "outer," and the like are used in the orientation or positional relationship indicated in the drawings for convenience in describing the present application and for simplicity in description, and are not intended to indicate or imply that the referenced devices or elements must have a particular orientation, be constructed in a particular orientation, and be operated in a particular manner, and are not to be considered limiting of the scope of the present application. Furthermore, the terms "first", "second", etc. are used for descriptive purposes only and are not to be construed as indicating or implying relative importance or implicitly indicating the number of technical features indicated. Thus, a feature defined as "first," "second," etc. may explicitly or implicitly include one or more of that feature. In the description of the invention, the meaning of "a plurality" is two or more unless otherwise specified.

In the description of the present application, it is to be noted that, unless otherwise explicitly specified or limited, the terms "mounted," "connected," and "connected" are to be construed broadly, e.g., as meaning either a fixed connection, a removable connection, or an integral connection; can be mechanically or electrically connected; they may be connected directly or indirectly through intervening media, or they may be interconnected between two elements. The specific meaning of the above terms in the present application can be understood by those of ordinary skill in the art through specific situations.

The technical solutions of the present application will be described in detail below with reference to the accompanying drawings in conjunction with embodiments.

Examples

The embodiment provides a liquid injection and suction device for a measuring chamber, which comprises a bracket 1, adriving assembly 2, aneedle assembly 3, a liquid injectionneedle sealing assembly 4 and a liquid suction needle sealing assembly 5 as shown in fig. 1, 2 and 3;

the support 1 consists of atop plate 11, avertical plate 12 and abase 13, thebase 13 is fixed on a measuringchamber cover plate 8 at the top of a measuring chamber, a rotary table 7 is arranged in the measuring chamber, a plurality of reaction cup containing positions which are arranged along the circumferential direction of the rotary table 7 and are used for containing reaction cups 6 are arranged on the rotary table 7, and the reaction cups 6 in the reaction cup containing positions can sequentially pass through a liquid injection position and a liquid suction position by driving the rotary table 7 to rotate through a driving piece;

theneedle assembly 3 comprises aliquid suction needle 32, aliquid injection needle 33 and aneedle fixing plate 31 fixedly connected with theliquid suction needle 32 and theliquid injection needle 33 and positioned at the upper part of the measuringchamber cover plate 8, theliquid suction needle 32 and theliquid injection needle 33 respectively penetrate through the measuringchamber cover plate 8 and correspond to the reaction cup 6 on the liquid suction level and the liquid injection level, and the needle point of theliquid suction needle 32 and the needle point of theliquid injection needle 33 have a certain height difference; furthermore, a notch is formed in the needle point of theliquid suction needle 32, so that the needle port can be prevented from being blocked when the needle port of theliquid suction needle 32 is attached to the bottom of the reaction cup 6, and theliquid injection needle 33 is provided with a conical needle point, so that the bufferliquid injection needle 33 can be prevented from hanging liquid;

thedriving assembly 2 comprises ascrew rod motor 21, atransmission screw rod 28, ascrew rod nut 29 which is spirally transmitted on thetransmission screw rod 28 and fixedly connected to aneedle fixing plate 31, adriving seat 23 fixed on theneedle fixing plate 31, a linear guide rail which is arranged on thevertical plate 12 and is parallel to thetransmission screw rod 28, and asliding block 26 which is fixed on thedriving seat 23 and is matched with the linear guide rail, wherein one end of thetransmission screw rod 28 is connected with an output shaft of thescrew rod motor 21, the other end of thetransmission screw rod 28 is connected with a measuringchamber cover plate 8 through abearing 22, aliquid suction needle 32 and aliquid injection needle 33 which are fixed on theneedle fixing plate 31 can move up and down through thescrew rod motor 21 and thetransmission screw rod 28, and thesliding block 26 is driven by theneedle fixing plate 31 and thedriving seat 23 to;

annotate liquidneedle seal assembly 4 and imbibition needle seal assembly 5 and be used for playing sealed effect when annotatingliquid needle 33 andimbibition needle 32's upper and lower operation to prevent the entering of external light, annotate liquidneedle seal assembly 4 and include: the liquid injection device comprises asealing column 44 arranged on a measuringchamber cover plate 8, a sealing column cover plate 43 arranged at the top of thesealing column 44, afirst sealing plug 42 arranged in a groove at the top of thesealing column 44 and connected with the sealing column cover plate 43, and a first O-shaped ring 41 arranged on the periphery of thefirst sealing plug 42, wherein through holes for aliquid injection needle 33 to pass through are formed in the sealing column cover plate 43, thefirst sealing plug 42 and thesealing column 44, and the bottom of thesealing column 44 is provided with an accommodating cavity with a diameter larger than the outer diameter of the liquid injection needle; the pipette needle seal assembly 5 includes: asecond sealing plug 52 arranged in a groove at the top of the measuringchamber cover plate 8 and connected with a sealingplug cover plate 51 arranged on the measuringchamber cover plate 8, and a second O-shaped ring 53 arranged on the periphery of thesecond sealing plug 52, wherein through holes for the liquid suckingneedle 32 to pass through are formed in the sealingplug cover plate 51 and thesecond sealing plug 52; annotate betweenliquid needle 33 and thefirst sealing plug 42, betweenimbibition needle 32 and thesecond sealing plug 52, between firstO shape circle 41 and thefirst sealing plug 42, all adopt interference fit between secondO shape circle 53 and thesecond sealing plug 52,first sealing plug 42,second sealing plug 52 hole adopts the bell mouth structure,first sealing plug 42,second sealing plug 52 further adopt wear-resisting black plastics, like black PTFE, black high rigidity PU, black UPE etc. can effectively avoid external light to get into the inside cavity of measuring chamber. In addition, the liquid injectionneedle sealing assembly 4 is designed withmore sealing columns 44 than the liquid suction needle assembly 5, mainly because the needle point of theliquid suction needle 32 and the needle point of theliquid injection needle 33 have a certain height difference, when theliquid suction needle 32 returns to the home position, if the liquid injection needle sealing assembly is arranged at the position of the measuringchamber cover plate 8 without thesealing columns 44, theliquid injection needle 33 and the sealing assembly can be separated.

Furthermore, two limit pins 27 are arranged at the upper and lower ends of thevertical plate 12 for limiting theslide block 26, that is, when the whole mechanism fails, theliquid suction needle 32 and theliquid injection needle 33 cannot be caused to operate upwards or downwards without limitation, so as to avoid failure, such as puncturing the reaction cup 6;

furthermore, anoptical coupler catch 24 is mounted on thedriving seat 23, and anoptical coupler 25 corresponding to theoptical coupler catch 24 is mounted on thevertical plate 12; before therotary disc 7 rotates, a signal is sent to a control system through the induction of the opticalcoupler blocking sheet 24 and theoptical coupler 25, and thewhole needle assembly 3 is reset; when theneedle assembly 3 is at the home position, theliquid suction needle 32 and theliquid injection needle 33 are positioned above (greater than mm) the cup holes of the corresponding reaction cups 6, so that the needle points are prevented from interfering with the rotation of the reaction cups 6 to cause faults, and theliquid suction needle 32, theliquid injection needle 33 and the needle points cannot be separated from the inner holes of thesealing plugs 42, so that theliquid suction needle 32 and theliquid injection needle 33 cannot align with the inner holes of thesealing plugs 42 when downwards running again;

further, theliquid suction needle 32 is connected with a waste liquid pipe, and the waste liquid pipe is connected with a waste liquid pump; theliquid injection needle 33 is connected with a liquid injection pipe, and the liquid injection pipe is connected with a liquid injection pump; when buffer solution is injected and waste solution is sucked, theliquid suction needle 32 and theliquid injection needle 33 are driven by thescrew rod motor 21 to slowly descend, in the descending process, the waste solution pump is always in a working state until theliquid suction needle 32 touches the bottom of the reaction cup 6, the liquid injection pump starts to work when the needle point of theliquid injection needle 33 enters the reaction cup 6, the buffer solution is injected into the reaction cup 6 in the prior art, and when theliquid suction needle 32 touches the bottom of the reaction cup 6, theliquid injection needle 33 cannot touch the buffer solution in the cup.

During the use, when reaction cup 6 rotates to annotateliquid needle 33 below, is in annotating the liquid level, when reaction cup 6 changes toimbibition needle 32 below, is in inhaling the liquid level, and in the continuous test, when preceding reaction cup 6 is in inhaling the waste liquid level, back reaction cup 6 is in annotating the liquid level, inhales the waste liquid promptly and annotates the buffer solution and go on simultaneously, has so saved test time greatly.

In light of the foregoing description of the preferred embodiments according to the present application, it is to be understood that various changes and modifications may be made without departing from the spirit and scope of the invention. The technical scope of the present application is not limited to the contents of the specification, and must be determined according to the scope of the claims.

Claims (10)

1. The utility model provides a measuring chamber annotates liquid and imbibition device which characterized in that includes:

the support (1) is fixed on a measuring chamber cover plate (8) at the top of the measuring chamber, a turntable (7) is arranged in the measuring chamber, a plurality of reaction cup containing positions which are arranged along the circumferential direction of the turntable (7) and used for containing reaction cups (6) are arranged on the turntable (7), and the reaction cups (6) in the reaction cup containing positions can sequentially pass through a liquid injection position and a liquid suction position by driving the turntable (7) to rotate through a driving piece;

the needle assembly (3) comprises a liquid suction needle (32), a liquid injection needle (33) and a needle fixing plate (31) fixedly connected with the liquid suction needle (32) and the liquid injection needle (33) and positioned at the upper part of the measuring chamber cover plate (8), and the liquid suction needle (32) and the liquid injection needle (33) respectively penetrate through the measuring chamber cover plate (8) and correspond to the reaction cups (6) on the liquid suction level and the liquid injection level;

the driving assembly (2) comprises a screw rod motor (21), a transmission screw rod (28), a screw rod nut (29) which is spirally transmitted on the transmission screw rod (28) and fixedly connected on a needle fixing plate (31), a driving seat (23) fixed on the needle fixing plate (31), a linear guide rail which is arranged on the bracket (1) and is parallel to the transmission screw rod (28) and a sliding block (26) which is fixed on the driving seat (23) and is matched with the linear guide rail, one end of the transmission screw rod (28) is connected with an output shaft of the screw rod motor (21), the other end is connected with the measuring chamber cover plate (8) through a bearing (22), the liquid suction needle (32) and the liquid injection needle (33) fixed on the needle fixing plate (31) can move up and down through the screw rod motor (21) and the transmission screw rod (28), and the sliding block (26) is driven by the needle fixing plate (31) and the driving seat (23) to move up and down along the linear guide rail.

2. The liquid injection and suction device for the measuring chamber as set forth in claim 1, wherein the tip of the liquid suction needle (32) and the tip of the liquid injection needle (33) have a certain height difference.

3. The measurement chamber liquid injection and suction device according to claim 2, further comprising a liquid injection needle sealing assembly (4) and a liquid suction needle sealing assembly (5), wherein the liquid injection needle sealing assembly (4) comprises: the sealing device comprises a sealing column (44) arranged on a measuring chamber cover plate (8), a sealing column cover plate (43) arranged at the top of the sealing column (44), a first sealing plug (42) arranged in a groove at the top of the sealing column (44) and connected with the sealing column cover plate (43), and a first O-shaped ring (41) arranged on the periphery of the first sealing plug (42), wherein through holes for a liquid injection needle (33) to penetrate through are formed in the sealing column cover plate (43), the first sealing plug (42) and the sealing column (44), and an accommodating cavity with the diameter larger than the outer diameter of the liquid injection needle is formed at the bottom of the sealing column (44); the pipette needle seal assembly (5) comprises: the second sealing plug (52) is arranged in a groove in the top of the measuring chamber cover plate (8) and connected with a sealing plug cover plate (51) arranged on the measuring chamber cover plate (8), a second O-shaped ring (53) is arranged on the periphery of the second sealing plug (52), and through holes for the liquid suction needle (32) to pass through are formed in the sealing plug cover plate (51) and the second sealing plug (52).

4. The liquid injection and suction device for the measuring chamber according to claim 3, wherein interference fit is adopted between the liquid injection needle (33) and the first sealing plug (42), between the liquid suction needle (32) and the second sealing plug (52), between the first O-shaped ring (41) and the first sealing plug (42), and between the second O-shaped ring (53) and the second sealing plug (52).

5. The filling and aspirating apparatus for measuring chambers as defined in claim 3 or 4, wherein the inner bores of the first and second sealing plugs (42, 52) are tapered, and the first and second sealing plugs (42, 52) are preferably made of wear-resistant black plastic.

6. The liquid injection and absorption device for the measuring chamber according to any one of claims 1 to 5, which comprises a top plate (11), a vertical plate (12), and a base (13), wherein the base (13) is fixed on the cover plate (101) of the measuring chamber, and the linear guide is arranged on the vertical plate (12).

7. The liquid injection and suction device for the measuring chamber as claimed in claim 6, wherein two limit pins (27) are provided at the upper and lower ends of the vertical plate (12) for limiting the slide block (26).

8. The liquid injection and suction device for the measuring chamber according to any one of claims 1 to 7, wherein the driving seat (23) is provided with an optical coupler stop sheet (24), and the vertical plate (12) is provided with an optical coupler (25) corresponding to the optical coupler stop sheet (24); before the rotary disc (7) rotates, the optical coupler separation blade (24) and the optical coupler (25) are used for sensing, so that a signal is sent to a control system, and the resetting of the whole needle assembly (3) is realized.

9. The filling and aspirating apparatus of any one of claims 1 to 8 wherein said aspirating needle (32) is connected to a waste line which is connected to a waste pump; the liquid injection needle (33) is connected with a liquid injection pipe, and the liquid injection pipe is connected with a liquid injection pump.

10. The liquid injection and suction device for the measuring chamber as claimed in any one of claims 1 to 9, wherein the tip of the liquid suction needle (32) is provided with a notch, and the liquid injection needle (33) preferably has a tapered tip.

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