CN111937860A - Isolated organ perfusion system - Google Patents

Abstract

Translated fromChinese

本发明涉及一种离体器官灌注系统，包括储液容器、离心泵、膜肺、第一蠕动泵、白细胞过滤器、血液透析器与废液袋。第一蠕动泵的进液端通过管路与储液容器相连通，第一蠕动泵的出液端通过管路与血液透析器的进液端相连通。血液透析器的出液端通过管路与储液容器相连通，血液透析器的排废端通过管路与废液袋相连通。储液容器、第一蠕动泵、血液透析器形成过滤循环辅路，白细胞过滤器设置于过滤循环辅路上。白细胞过滤器因为长时间工作而导致堵塞时，白细胞过滤器会导致过滤循环辅路发生堵塞，而并不会导致灌注循环主路发生堵塞，此时灌注循环主路仍然可以继续工作，能持续对离体器官起到保护作用，并及时更换过滤循环辅路上的白细胞过滤器即可。

The invention relates to an isolated organ perfusion system, comprising a liquid storage container, a centrifugal pump, a membrane lung, a first peristaltic pump, a white blood cell filter, a hemodialyzer and a waste liquid bag. The liquid inlet end of the first peristaltic pump is communicated with the liquid storage container through the pipeline, and the liquid outlet end of the first peristaltic pump is communicated with the liquid inlet end of the hemodialyzer through the pipeline. The liquid outlet end of the hemodialyzer is communicated with the liquid storage container through the pipeline, and the waste discharge end of the hemodialyzer is communicated with the waste liquid bag through the pipeline. The liquid storage container, the first peristaltic pump, and the hemodialyzer form an auxiliary circuit for filtration and circulation, and the leukocyte filter is arranged on the auxiliary circuit for filtration and circulation. When the leukocyte filter is blocked due to long-term work, the leukocyte filter will cause the auxiliary circuit of the filtration cycle to be blocked, but will not cause the main circuit of the perfusion cycle to be blocked. At this time, the main circuit of the perfusion cycle can still continue to work The body organs play a protective role, and the white blood cell filter on the auxiliary road of the filtering circulation can be replaced in time.

Description

Translated fromChinese

离体器官灌注系统Isolated Organ Perfusion System

技术领域technical field

本发明涉及灌注装置技术领域，特别是涉及一种离体器官灌注系统。The present invention relates to the technical field of perfusion devices, in particular to an isolated organ perfusion system.

背景技术Background technique

机械灌注是将器官保存、转运的一种方式，器官被获取后将自身血管连接至离体器官灌注系统，离体器官灌注系统在器官保存和转运阶段将灌流液持续灌注至离体器官，同时供给离体器官氧气和营养物等。Mechanical perfusion is a way of organ preservation and transport. After the organ is harvested, its own blood vessels are connected to the isolated organ perfusion system. The isolated organ perfusion system continuously perfuses the perfusate into the isolated organ during the organ preservation and transport stage. Supply of oxygen and nutrients to isolated organs.

传统技术中，离体器官灌注系统包括膜肺、储液容器、废液罐、白细胞过滤器及透析器。储液容器、离心泵、白细胞过滤器、膜肺与离体器官形成主路，储液容器、蠕动泵、透析器与废液罐形成支路。一般地，工作人员做灌注前需将各种所需耗材搭建组装在一起，然后再对离体器官进行灌注工作，各种耗材的现场组装工作不仅提高了实验或临床难度，同时降低了工作效率。In the traditional technology, the isolated organ perfusion system includes membrane lung, fluid storage container, waste fluid tank, leukocyte filter and dialyzer. The liquid storage container, centrifugal pump, leukocyte filter, membrane lung and isolated organs form the main circuit, and the liquid storage container, peristaltic pump, dialyzer and waste liquid tank form the branch circuit. Generally, before performing perfusion, the staff needs to build and assemble various required consumables together, and then perform perfusion work on isolated organs. The on-site assembly of various consumables not only increases the difficulty of experiments or clinical practice, but also reduces work efficiency. .

发明内容SUMMARY OF THE INVENTION

基于此，有必要克服现有技术的缺陷，提供一种离体器官灌注系统，它能够提高工作效率，降低实验难度，提高实验成功率。Based on this, it is necessary to overcome the defects of the prior art and provide an isolated organ perfusion system, which can improve the work efficiency, reduce the difficulty of the experiment, and improve the success rate of the experiment.

其技术方案如下：一种离体器官灌注系统，所述离体器官灌注系统包括：外套包、储液容器、辅助安装壳、血液透析器与膜肺，所述储液容器设置于所述外套包中，所述储液容器用于装设灌注液，所述辅助安装壳可拆卸地设置于所述外套包中，所述血液透析器与所述膜肺均可拆卸地设置于所述辅助安装壳中。The technical solution is as follows: an isolated organ perfusion system, the isolated organ perfusion system includes: an outer casing, a liquid storage container, an auxiliary installation shell, a hemodialyzer and a membrane lung, and the liquid storage container is arranged in the outer casing In the bag, the liquid storage container is used to install perfusate, the auxiliary installation shell is detachably arranged in the outer bag, and the hemodialyzer and the membrane lung can be detachably arranged in the auxiliary installed in the shell.

上述的离体器官灌注系统，血液透析器与膜肺均属于耗材，将血液透析器与膜肺装设于辅助安装壳中，辅助安装壳与储液容器均装设于外套包中，在使用时，直接将离体器官放入到储液容器中并接入到灌注管路中即可，无需现场组装耗材并在组装完耗材后进行消毒工作，如此能够提高实验工作效率。此外，当其中一个耗材出现故障时，可以将辅助安装壳连带耗材整体进行更换，也可以将出现故障的耗材单独进行更换，操作较为方便。In the above-mentioned isolated organ perfusion system, both the hemodialyzer and the membrane lung are consumables. The hemodialyzer and the membrane lung are installed in the auxiliary installation shell, and the auxiliary installation shell and the liquid storage container are installed in the outer bag. When assembling, the isolated organs can be directly put into the liquid storage container and connected to the perfusion pipeline. There is no need to assemble the consumables on site and sterilize the consumables after assembling, which can improve the efficiency of the experimental work. In addition, when one of the consumables fails, the auxiliary installation shell together with the consumables can be replaced as a whole, or the failed consumables can be replaced individually, which is more convenient to operate.

在其中一个实施例中，所述离体器官灌注系统还包括PH监测仪、微栓过滤器与白细胞过滤器，所述PH监测仪、所述微栓过滤器与所述白细胞过滤器均可拆卸地装设于所述辅助安装壳中。In one embodiment, the isolated organ perfusion system further includes a pH monitor, a microembolism filter and a leukocyte filter, and the pH monitor, the microembolism filter and the leukocyte filter are all removable installed in the auxiliary installation shell.

在其中一个实施例中，所述离体器官灌注系统还包括设置于所述辅助安装壳上的第一夹具、第二夹具、第三夹具、第四夹具与第五夹具；所述血液透析器可拆卸地装设于所述第一夹具上，所述膜肺可拆卸地装设于所述第二夹具上，所述PH监测仪可拆卸地设置于所述第三夹具上，所述微栓过滤器可拆卸地设置于所述第四夹具上，所述白细胞过滤器可拆卸地设置于所述第五夹具上。In one embodiment, the isolated organ perfusion system further includes a first clamp, a second clamp, a third clamp, a fourth clamp and a fifth clamp arranged on the auxiliary installation shell; the hemodialyzer Removably mounted on the first fixture, the membrane lung is detachably mounted on the second fixture, the pH monitor is detachably mounted on the third fixture, the micro The plug filter is detachably arranged on the fourth fixture, and the leukocyte filter is detachably arranged on the fifth fixture.

在其中一个实施例中，所述第一夹具包括相对设置于所述辅助安装壳上的两个第一夹持板，所述第一夹持板设有与所述血液透析器的侧壁相适应的第一弧形面；所述第二夹具包括相对设置于所述辅助安装壳上的两个第二夹持板，所述第二夹持板设有与所述膜肺的侧壁相适应的第二弧形面；所述第三夹具包括相对设置于所述辅助安装壳上的两个第三夹持板，所述第三夹持板设有与所述PH监测仪的侧壁相适应的第三弧形面；所述第四夹具包括设置于所述辅助安装壳上的支撑板，所述支撑板上设有相对并同轴的两个弧形孔，以及与所述弧形孔的端部对应连通的过孔，所述微栓过滤器底面上的两个第一锁扣结构与两个所述过孔一一对应设置，所述第一锁扣结构能穿过所述过孔并能沿着所述弧形孔移动，所述第一锁扣结构的扣板面积尺寸大于所述弧形孔的宽度。In one of the embodiments, the first clamp includes two first clamping plates oppositely arranged on the auxiliary installation shell, and the first clamping plates are arranged opposite to the side wall of the hemodialyzer. The first arc-shaped surface is adapted; the second clamp includes two second clamping plates oppositely arranged on the auxiliary installation shell, and the second clamping plates are provided with the side walls of the membrane lung. The second arc-shaped surface is adapted; the third clamp includes two third clamping plates arranged opposite to the auxiliary installation shell, and the third clamping plates are provided with the side walls of the PH monitor. a corresponding third arc-shaped surface; the fourth clamp includes a support plate arranged on the auxiliary installation shell, the support plate is provided with two opposite and coaxial arc-shaped holes, and a The ends of the shaped holes correspond to the connected via holes, the two first locking structures on the bottom surface of the micro-bolt filter are arranged in a one-to-one correspondence with the two via holes, and the first locking structures can pass through all the holes. The via hole can move along the arc-shaped hole, and the area size of the buckle plate of the first locking structure is larger than the width of the arc-shaped hole.

在其中一个实施例中，所述离体器官灌注系统还包括离心泵、第一蠕动泵及废液袋；所述离心泵的进液端通过管路与所述储液容器相连通，所述离心泵的出液端通过管路与所述膜肺的进液端相连通，所述膜肺的出液端通过管路用于与离体器官相连，所述储液容器、所述离心泵、所述膜肺与所述离体器官形成灌注循环主路；In one embodiment, the isolated organ perfusion system further includes a centrifugal pump, a first peristaltic pump and a waste bag; the liquid inlet end of the centrifugal pump is communicated with the liquid storage container through a pipeline, and the The liquid outlet end of the centrifugal pump is communicated with the liquid inlet end of the membrane lung through a pipeline, and the liquid outlet end of the membrane lung is connected to the isolated organ through a pipeline, and the liquid storage container, the centrifugal pump , the membrane lung and the isolated organ form the main circuit of perfusion circulation;

所述第一蠕动泵的进液端通过管路与所述储液容器相连通，所述第一蠕动泵的出液端通过管路与所述血液透析器的进液端相连通，所述血液透析器的出液端通过管路与所述储液容器相连通，所述血液透析器的排废端通过管路与所述废液袋相连通，所述储液容器、所述第一蠕动泵、所述血液透析器形成过滤循环辅路，所述白细胞过滤器设置于所述灌注循环主路上或所述过滤循环辅路上，所述微栓过滤器设置于所述灌注循环主路上或设置于所述过滤循环辅路上。The liquid inlet end of the first peristaltic pump is communicated with the liquid storage container through a pipeline, and the liquid outlet end of the first peristaltic pump is communicated with the liquid inlet end of the hemodialyzer through a pipeline. The liquid outlet end of the hemodialyzer is communicated with the liquid storage container through a pipeline, and the waste discharge end of the hemodialyzer is communicated with the waste liquid bag through a pipeline. The peristaltic pump and the hemodialyzer form an auxiliary circuit of filtration circulation, the leukocyte filter is arranged on the main road of the perfusion circulation or the auxiliary circuit of the filtration circulation, and the micro-plug filter is arranged on the main road of the perfusion circulation or on the filtration cycle auxiliary road.

在其中一个实施例中，所述白细胞过滤器设置于所述第一蠕动泵与所述血液透析器之间的管路上。In one embodiment, the leukocyte filter is arranged on the pipeline between the first peristaltic pump and the hemodialyzer.

在其中一个实施例中，所述离体器官灌注系统还包括第一压力传感器与第二压力传感器，所述第一压力传感器设置于所述白细胞过滤器的出液端或进液端，所述第二压力传感器设置于所述膜肺的出液端。In one embodiment, the isolated organ perfusion system further includes a first pressure sensor and a second pressure sensor, the first pressure sensor is disposed at the liquid outlet end or the liquid inlet end of the leukocyte filter, the The second pressure sensor is arranged at the liquid outlet end of the membrane lung.

在其中一个实施例中，所述离体器官灌注系统还包括第一传感器夹具与第二传感器夹具；所述第一传感器夹具装设于所述辅助安装壳上或者装设于所述储液容器的外侧壁上，所述第一压力传感器可拆卸地装设于所述第一传感器夹具上；所述第二传感器夹具装设于所述储液容器的外侧壁上，所述第二压力传感器可拆卸地装设于所述第二传感器夹具上。In one embodiment, the isolated organ perfusion system further includes a first sensor fixture and a second sensor fixture; the first sensor fixture is mounted on the auxiliary mounting shell or mounted on the liquid storage container On the outer side wall of the liquid storage container, the first pressure sensor is detachably installed on the first sensor clamp; the second sensor clamp is installed on the outer side wall of the liquid storage container, the second pressure sensor Removably mounted on the second sensor fixture.

在其中一个实施例中，所述第一传感器夹具包括底板及连接于所述底板的相对两侧的两个L形限位板；所述底板装设于所述辅助安装壳上或者装设于所述储液容器的外侧壁上，所述L形限位板上设有条形口，所述L形限位板与所述第一压力传感器的座板限位配合以防止所述座板在垂直于所述底板板面的方向上移动，所述座板能沿着所述底板的板面滑动，所述座板上设有与所述条形口位置对应的安装孔，所述座板通过安装件穿过所述条形口及所述安装孔装设于所述L形限位板上。In one embodiment, the first sensor fixture includes a bottom plate and two L-shaped limit plates connected to opposite sides of the bottom plate; the bottom plate is mounted on the auxiliary mounting shell or mounted on On the outer side wall of the liquid storage container, the L-shaped limit plate is provided with a strip-shaped opening, and the L-shaped limit plate is limitedly matched with the seat plate of the first pressure sensor to prevent the seat plate Moving in a direction perpendicular to the surface of the bottom plate, the seat plate can slide along the surface of the bottom plate, and the seat plate is provided with a mounting hole corresponding to the position of the strip opening, and the seat plate can slide along the surface of the bottom plate. The plate is mounted on the L-shaped limiting plate through the strip opening and the mounting hole through the mounting piece.

在其中一个实施例中，所述辅助安装壳的壁上设有第二锁扣结构，所述外套包的壁上设有与所述第二锁扣结构对应的扣孔，所述第二锁扣结构设置于所述扣孔中；所述离体器官灌注系统还包括支架与第二盖体，所述支架设置于所述储液容器的内壁上，所述支架用于支撑放置离体器官；所述第二盖体可打开地设置于所述储液容器的口部；所述离体器官灌注系统还包括连通管与液位传感器，所述连通管位于所述储液容器外，所述连通管的底端与所述储液容器相连通，所述液位传感器设置于所述连通管上，所述液位传感器用于获取所述连通管上的液位高度。In one embodiment, a second lock structure is provided on the wall of the auxiliary installation shell, a button hole corresponding to the second lock structure is provided on the wall of the outer bag, and the second lock The button structure is arranged in the button hole; the isolated organ perfusion system further includes a bracket and a second cover, the bracket is arranged on the inner wall of the liquid storage container, and the bracket is used to support and place the isolated organ ; the second cover can be opened at the mouth of the liquid storage container; the isolated organ perfusion system also includes a communication pipe and a liquid level sensor, the communication pipe is located outside the liquid storage container, so The bottom end of the communication pipe is communicated with the liquid storage container, the liquid level sensor is arranged on the communication pipe, and the liquid level sensor is used to obtain the liquid level height on the communication pipe.

附图说明Description of drawings

图1为本发明一实施例中的离体器官灌注系统的结构示意图；FIG. 1 is a schematic structural diagram of an isolated organ perfusion system according to an embodiment of the present invention;

图2为本发明一实施例中的离体器官灌注系统的第一盖体省略掉后的结构示意图；2 is a schematic structural diagram of an isolated organ perfusion system in an embodiment of the present invention after the first cover is omitted;

图3为本发明一实施例中的离体器官灌注系统的分解示意图；3 is an exploded schematic diagram of an isolated organ perfusion system according to an embodiment of the present invention;

图4为本发明一实施例中的离体器官灌注系统的辅助安装壳的其中一视角结构图；FIG. 4 is a structural view of an auxiliary installation shell of an isolated organ perfusion system according to an embodiment of the present invention;

图5为本发明一实施例中的离体器官灌注系统的辅助安装壳的另一视角结构图；5 is a structural diagram of another perspective view of the auxiliary installation shell of the isolated organ perfusion system according to an embodiment of the present invention;

图6为本发明一实施例中的离体器官灌注系统的辅助安装壳装好耗材的其中一视角结构图；FIG. 6 is a perspective structural diagram of an auxiliary installation shell of an isolated organ perfusion system with consumables installed in an embodiment of the present invention;

图7为本发明一实施例中的离体器官灌注系统的辅助安装壳装好耗材的另一视角结构图；FIG. 7 is another perspective structural diagram of the auxiliary installation shell of the isolated organ perfusion system in accordance with an embodiment of the present invention with consumables installed;

图8为本发明一实施例中的离体器官灌注系统的储液容器装设有第一压力传感器与第二压力传感器的结构示意图；8 is a schematic structural diagram of a liquid storage container of an isolated organ perfusion system equipped with a first pressure sensor and a second pressure sensor according to an embodiment of the present invention;

图9为图8在A处的放大结构示意图；9 is an enlarged schematic view of FIG. 8 at A;

图10为本发明一实施例中的离体器官灌注系统的储液容器未装设有第一压力传感器与第二压力传感器的结构示意图；10 is a schematic structural diagram of the liquid storage container of the isolated organ perfusion system without the first pressure sensor and the second pressure sensor installed in an embodiment of the present invention;

图11为本发明一实施例中的离体器官灌注系统的结构示意图；11 is a schematic structural diagram of an isolated organ perfusion system according to an embodiment of the present invention;

图12为图11在B处的放大结构示意图；Fig. 12 is the enlarged schematic diagram of Fig. 11 at B;

图13为本发明一实施例中的离体器官灌注系统的剖开后的其中一部分结构示意图；FIG. 13 is a schematic structural diagram of a part of the isolated organ perfusion system after being cut away in an embodiment of the present invention;

图14为本发明一实施例中的离体器官灌注系统的剖开后的另一部分结构示意图；FIG. 14 is a schematic structural diagram of another part of the isolated organ perfusion system after cutting in an embodiment of the present invention;

图15为图14在C处的放大结构示意图；FIG. 15 is an enlarged schematic view of FIG. 14 at C;

图16为本发明一实施例中的离体器官灌注系统的简化示意图。16 is a simplified schematic diagram of an isolated organ perfusion system in accordance with an embodiment of the present invention.

10、外套包；11、第一盖体；12、扣孔；20、储液容器；21、梯形凸台； 22、出液口；23、接头；24、支架；25、第二盖体；30、辅助安装壳；31、第二锁扣结构；41、血液透析器；42、膜肺；43、PH监测仪；44、微栓过滤器； 441、第一锁扣结构；45、离心泵；46、第一蠕动泵；47、废液袋；48、第一压力传感器；481、座板；482、安装孔；49、第二压力传感器；51、第一夹具；511、第一夹持板；52、第二夹具；521、第二夹持板；53、第三夹具；531、第三夹持板；54、第四夹具；541、支撑板；542、弧形孔；543、过孔；55、第一传感器夹具；551、底板；552、L形限位板；553、条形口；56、第二传感器夹具；57、白细胞过滤器；61、连通管；62、液位传感器；63、导流架；631、顶板；632、脚板；633、间隙；64、第一开关阀；65、补液袋；66、第二开关阀； 67、第二蠕动泵；68、第一温度传感器；69、第二温度传感器；70、流量传感器。10. Outer bag; 11. First cover; 12. Button hole; 20. Liquid storage container; 21. Trapezoidal boss; 22. Liquid outlet; 23. Joint; 24. Support; 25. Second cover; 30. Auxiliary installation shell; 31. Second locking structure; 41. Hemodialyzer; 42. Membrane lung; 43. PH monitor; 44. Microembolized filter; 441. First locking structure; 45.Centrifugal pump 46, the first peristaltic pump; 47, the waste bag; 48, the first pressure sensor; 481, the seat plate; 482, the mounting hole; 49, the second pressure sensor; 51, the first clamp; 511, the first clamping plate; 52, second clamp; 521, second clamp plate; 53, third clamp; 531, third clamp plate; 54, fourth clamp; 541, support plate; 542, arc hole; 543, pass hole; 55, the first sensor fixture; 551, the bottom plate; 552, the L-shaped limit plate; 553, the bar mouth; 56, the second sensor fixture; 57, the leukocyte filter; 61, the connecting pipe; 62, theliquid level sensor 63, guide frame; 631, top plate; 632, foot plate; 633, clearance; 64, the first on-off valve; 65, rehydration bag; 66, the second on-off valve; 67, the second peristaltic pump; 68, the first temperature sensor; 69, a second temperature sensor; 70, a flow sensor.

具体实施方式Detailed ways

为使本发明的上述目的、特征和优点能够更加明显易懂，下面结合附图对本发明的具体实施方式做详细的说明。在下面的描述中阐述了很多具体细节以便于充分理解本发明。但是本发明能够以很多不同于在此描述的其它方式来实施，本领域技术人员可以在不违背本发明内涵的情况下做类似改进，因此本发明不受下面公开的具体实施例的限制。In order to make the above objects, features and advantages of the present invention more clearly understood, the specific embodiments of the present invention will be described in detail below with reference to the accompanying drawings. In the following description, numerous specific details are set forth in order to provide a thorough understanding of the present invention. However, the present invention can be implemented in many other ways different from those described herein, and those skilled in the art can make similar improvements without departing from the connotation of the present invention. Therefore, the present invention is not limited by the specific embodiments disclosed below.

参阅图1、图6与图7，图1示出了本发明一实施例中的离体器官灌注系统的结构示意图，图6示意出了本发明一实施例中的离体器官灌注系统的辅助安装壳30装好耗材的其中一视角结构图，图7示意出了本发明一实施例中的离体器官灌注系统的辅助安装壳30装好耗材的另一视角结构图。一种离体器官灌注系统，离体器官灌注系统包括：外套包10、储液容器20、辅助安装壳30、血液透析器41与膜肺42。储液容器20设置于外套包10中，储液容器20用于装设灌注液，辅助安装壳30可拆卸地设置于外套包10中，血液透析器41与膜肺 42均可拆卸地设置于辅助安装壳30中。Referring to FIG. 1, FIG. 6 and FIG. 7, FIG. 1 shows a schematic structural diagram of an isolated organ perfusion system in an embodiment of the present invention, and FIG. 6 illustrates the assistance of the isolated organ perfusion system in an embodiment of the present invention Fig. 7 shows another view of the structure of theauxiliary installation shell 30 of the isolated organ perfusion system in accordance with an embodiment of the present invention with consumables installed. An isolated organ perfusion system, the isolated organ perfusion system includes: anouter casing 10 , aliquid storage container 20 , anauxiliary installation shell 30 , ahemodialyzer 41 and amembrane lung 42 . Theliquid storage container 20 is arranged in theouter casing 10, theliquid storage container 20 is used for installing the perfusion fluid, theauxiliary installation shell 30 is detachably arranged in theouter casing 10, and the hemodialyzer 41 and themembrane lung 42 can be detachably arranged in theouter casing 10.Auxiliary installation case 30.

上述的离体器官灌注系统，血液透析器41与膜肺42均属于耗材，将血液透析器41与膜肺42装设于辅助安装壳30中，辅助安装壳30与储液容器20均装设于外套包10中，在使用时，直接将离体器官放入到储液容器20中并接入到灌注管路中即可，无需现场组装耗材并在组装完耗材后进行消毒工作，如此能够提高实验工作效率。此外，当其中一个耗材出现故障时，可以将辅助安装壳30连带耗材整体进行更换，也可以将出现故障的耗材单独进行更换，操作较为方便。In the above-mentioned isolated organ perfusion system, thehemodialyzer 41 and themembrane lung 42 are consumables, and the hemodialyzer 41 and themembrane lung 42 are installed in theauxiliary installation shell 30, and theauxiliary installation shell 30 and theliquid storage container 20 are both installed. In theouter bag 10, when in use, the isolated organ can be directly put into theliquid storage container 20 and connected to the perfusion pipeline. It is not necessary to assemble the consumables on site and perform disinfection work after assembling the consumables. Improve experimental work efficiency. In addition, when one of the consumables fails, theauxiliary installation shell 30 together with the consumables can be replaced as a whole, or the failed consumables can be replaced individually, which is more convenient to operate.

请参阅图2、图6与图7，图2示意出了本发明一实施例中的离体器官灌注系统的第一盖体11省略掉后的结构示意图。进一步地，离体器官灌注系统还包括PH监测仪43、微栓过滤器44与白细胞过滤器57。PH监测仪43、微栓过滤器44与白细胞过滤器57均可拆卸地装设于辅助安装壳30中。如此，当离体器官灌注系统还包括PH监测仪43、微栓过滤器44与白细胞过滤器57时，也会将 PH监测仪43、微栓过滤器44与白细胞过滤器57可拆卸地装设于辅助安装壳30 中，使得PH监测仪43、微栓过滤器44与白细胞过滤器57这三者，和血液透析器41与膜肺42这两者都装在同一个辅助安装壳30中，可先通过管路连接形成一个组合模块，在使用时，直接将离体器官放入到储液容器20中并接入到灌注管路中即可，无需现场组装耗材并在组装完耗材后进行消毒工作，如此能够提高实验工作效率。此外，当其中一个耗材出现故障时，可以将辅助安装壳30连带耗材整体进行更换，也可以将出现故障的耗材单独进行更换，操作较为方便。Please refer to FIG. 2 , FIG. 6 and FIG. 7 . FIG. 2 is a schematic diagram showing the structure of the isolated organ perfusion system in which thefirst cover 11 is omitted according to an embodiment of the present invention. Further, the isolated organ perfusion system also includes apH monitor 43 , amicroplug filter 44 and aleukocyte filter 57 . ThepH monitor 43 , themicroplug filter 44 and theleukocyte filter 57 can be detachably installed in theauxiliary installation housing 30 . In this way, when the isolated organ perfusion system further includes thepH monitor 43, themicroembolizer filter 44 and theleukocyte filter 57, thepH monitor 43, themicroembolizer filter 44 and theleukocyte filter 57 are also detachably installed In theauxiliary installation case 30, thepH monitor 43, themicroembolism filter 44 and theleukocyte filter 57, and the hemodialyzer 41 and themembrane lung 42 are both installed in the sameauxiliary installation case 30, A combined module can be formed through pipeline connection first, and when in use, the isolated organ can be directly put into theliquid storage container 20 and connected to the perfusion pipeline. Disinfection work, which can improve the efficiency of experimental work. In addition, when one of the consumables fails, theauxiliary installation shell 30 together with the consumables can be replaced as a whole, or the failed consumables can be replaced individually, which is more convenient to operate.

请参阅图3至图7，图3示意出了本发明一实施例中的离体器官灌注系统的分解示意图，图4示意出了本发明一实施例中的离体器官灌注系统的辅助安装壳30的其中一视角结构图，图5示意出了本发明一实施例中的离体器官灌注系统的辅助安装壳30的另一视角结构图，图6示意出了本发明一实施例中的离体器官灌注系统的辅助安装壳30装好耗材的其中一视角结构图，图7示意出了本发明一实施例中的离体器官灌注系统的辅助安装壳30装好耗材的另一视角结构图。进一步地，离体器官灌注系统还包括设置于辅助安装壳30上的第一夹具51、第二夹具52、第三夹具53、第四夹具54与第五夹具。血液透析器41可拆卸地装设于第一夹具51上，膜肺42可拆卸地装设于第二夹具52上，PH监测仪43 可拆卸地设置于第三夹具53上，微栓过滤器44可拆卸地设置于第四夹具54上，白细胞过滤器57可拆卸地设置于第五夹具上。如此，血液透析器41、膜肺42、 PH监测仪43、微栓过滤器44与白细胞过滤器57均会有对应的夹具进行夹持固定，方便进行单个耗材的安装拆卸更换工作。Please refer to FIGS. 3 to 7 , FIG. 3 is an exploded schematic diagram of an isolated organ perfusion system in an embodiment of the present invention, and FIG. 4 is a schematic diagram illustrating an auxiliary installation shell of the isolated organ perfusion system in an embodiment of thepresent invention 30 is a structural diagram from one perspective, FIG. 5 illustrates another perspective structural diagram of theauxiliary installation shell 30 of the isolated organ perfusion system in an embodiment of the present invention, and FIG. 6 illustrates an isolated organ perfusion system in an embodiment of the present invention. A structural view of theauxiliary installation shell 30 of the body organ perfusion system with consumables installed, and FIG. 7 illustrates another view of theauxiliary installation shell 30 of the isolated organ perfusion system in accordance with an embodiment of the present invention with consumables installed. . Further, the isolated organ perfusion system further includes afirst clamp 51 , asecond clamp 52 , athird clamp 53 , afourth clamp 54 and a fifth clamp arranged on theauxiliary installation shell 30 . Thehemodialyzer 41 is detachably mounted on thefirst fixture 51, themembrane lung 42 is detachably mounted on thesecond fixture 52, thepH monitor 43 is detachably mounted on thethird fixture 53, and themicroembolized filter 44 is detachably arranged on thefourth fixture 54, and theleukocyte filter 57 is detachably arranged on the fifth fixture. In this way, thehemodialyzer 41, themembrane lung 42, thepH monitor 43, themicroembolism filter 44 and theleukocyte filter 57 all have corresponding clamps for clamping and fixing, which facilitates the installation, disassembly and replacement of a single consumable.

请参阅图4至图7，进一步地，第一夹具51包括相对设置于辅助安装壳30 上的两个第一夹持板511。第一夹持板511设有与血液透析器41的侧壁相适应的第一弧形面。第二夹具52包括相对设置于辅助安装壳30上的两个第二夹持板521。第二夹持板521设有与膜肺42的侧壁相适应的第二弧形面。第三夹具 53包括相对设置于辅助安装壳30上的两个第三夹持板531。第三夹持板531设有与PH监测仪43的侧壁相适应的第三弧形面。第四夹具54包括设置于辅助安装壳30上的支撑板541，支撑板541上设有相对并同轴的两个弧形孔542，以及与弧形孔542的端部对应连通的过孔543。微栓过滤器44底面上的两个第一锁扣结构441与两个过孔543一一对应设置，第一锁扣结构441能穿过过孔543 并能沿着弧形孔542移动，第一锁扣结构441的扣板面积尺寸大于弧形孔542 的宽度。Please refer to FIG. 4 to FIG. 7 , further, thefirst clamp 51 includes twofirst clamping plates 511 oppositely disposed on theauxiliary mounting shell 30 . Thefirst clamping plate 511 is provided with a first arc surface adapted to the side wall of thehemodialyzer 41 . Thesecond clamp 52 includes twosecond clamping plates 521 oppositely disposed on theauxiliary mounting shell 30 . Thesecond clamping plate 521 is provided with a second arc-shaped surface adapted to the side wall of themembrane lung 42 . Thethird clamp 53 includes twothird clamping plates 531 that are oppositely disposed on theauxiliary mounting shell 30. Thethird clamping plate 531 is provided with a third arc-shaped surface which is adapted to the side wall of thepH monitor 43 . Thefourth clamp 54 includes asupport plate 541 disposed on theauxiliary installation shell 30 . Thesupport plate 541 is provided with two opposite and coaxial arc holes 542 , and a viahole 543 corresponding to the end of thearc hole 542 . . The twofirst locking structures 441 on the bottom surface of themicrobolt filter 44 are arranged in a one-to-one correspondence with the two viaholes 543. Thefirst locking structures 441 can pass through the via holes 543 and move along the arc-shapedholes 542. The area size of the locking plate of a lockingstructure 441 is larger than the width of the arc-shapedhole 542 .

如此，两个第一夹持板511的第一弧形面分别夹持于血液透析器41的相对侧壁，即可实现第一夹具51夹持固定血液透析器41。两个第二夹持板521的第二弧形面分别夹持于膜肺42的相对侧壁，即可实现第二夹具52夹持固定膜肺 42。两个第三夹持板531的第三弧形面分别夹持于PH监测仪43的相对侧壁，即可实现第三夹具53夹持固定PH监测仪43。In this way, the first arc surfaces of the twofirst clamping plates 511 are respectively clamped on the opposite side walls of thehemodialyzer 41 , so that thefirst clamp 51 can clamp and fix thehemodialyzer 41 . The second arc surfaces of the twosecond clamping plates 521 are respectively clamped on the opposite side walls of themembrane lung 42, so that thesecond clamp 52 can clamp and fix themembrane lung 42. The third arc surfaces of the twothird clamping plates 531 are respectively clamped on opposite side walls of thepH monitor 43 , so that thethird clamp 53 can clamp and fix thepH monitor 43 .

需要说明的是，弧形孔542的宽度指的是弧形孔542的内圆与外圆之间的间距大小，第一锁扣结构441的扣板面积尺寸大于弧形孔542的宽度时，使得支撑板541对于第一锁扣结构441的扣板具有限位作用，也就是能实现微栓过滤器44固定于第四夹具54上，当需要从第四夹具54上拆卸下微栓过滤器44 时，转动微栓过滤器44使得微栓过滤器44的第一锁扣结构441与过孔543对位，向上移动微栓过滤器44，微栓过滤器44的第一锁扣结构441穿过过孔543 即可。It should be noted that the width of the arc-shapedhole 542 refers to the distance between the inner circle and the outer circle of the arc-shapedhole 542 . Thesupport plate 541 has a limiting effect on the buckle plate of thefirst locking structure 441, that is, themicro-plug filter 44 can be fixed on thefourth fixture 54, and when the micro-plug filter needs to be removed from thefourth fixture 54. At 44 hours, rotate themicro-plug filter 44 so that thefirst locking structure 441 of themicro-plug filter 44 is aligned with the viahole 543, move themicro-plug filter 44 upward, and thefirst locking structure 441 of themicro-plug filter 44 passes through. The viahole 543 can be used.

需要说明的是，白细胞过滤器57型号不同，对应的形状不同，因此第五夹具的形状可以根据白细胞过滤器57不同的型号进行相适应性设计，在此不进行赘述。It should be noted that different models of theleukocyte filter 57 have different corresponding shapes. Therefore, the shape of the fifth clamp can be adaptively designed according to different models of theleukocyte filter 57 , which will not be described here.

请参阅图16，图16示意出了本发明一实施例中的离体器官灌注系统的简化示意图。在一个实施例中，离体器官灌注系统还包括离心泵45、第一蠕动泵46 及废液袋47。离心泵45的进液端通过管路与储液容器20相连通，离心泵45的出液端通过管路与膜肺42的进液端相连通，膜肺42的出液端通过管路用于与离体器官相连，储液容器20、离心泵45、膜肺42与离体器官形成灌注循环主路。Please refer to FIG. 16, which illustrates a simplified schematic diagram of an isolated organ perfusion system according to an embodiment of the present invention. In one embodiment, the isolated organ perfusion system further includes acentrifugal pump 45 , a firstperistaltic pump 46 and a waste bag 47 . The liquid inlet end of thecentrifugal pump 45 is communicated with theliquid storage container 20 through the pipeline, the liquid outlet end of thecentrifugal pump 45 is communicated with the liquid inlet end of themembrane lung 42 through the pipeline, and the liquid outlet end of themembrane lung 42 is passed through the pipeline. In connection with the isolated organ, theliquid storage container 20, thecentrifugal pump 45, themembrane lung 42 and the isolated organ form the main circuit of perfusion circulation.

此外，第一蠕动泵46的进液端通过管路与储液容器20相连通，第一蠕动泵46的出液端通过管路与血液透析器41的进液端相连通，血液透析器41的出液端通过管路与储液容器20相连通，血液透析器41的排废端通过管路与废液袋47相连通，储液容器20、第一蠕动泵46、血液透析器41形成过滤循环辅路，白细胞过滤器57设置于灌注循环主路上或过滤循环辅路上，微栓过滤器44设置于灌注循环主路上或设置于过滤循环辅路上。In addition, the liquid inlet end of the firstperistaltic pump 46 is communicated with theliquid storage container 20 through the pipeline, and the liquid outlet end of the firstperistaltic pump 46 is communicated with the liquid inlet end of thehemodialyzer 41 through the pipeline, and thehemodialyzer 41 The liquid outlet end is communicated with theliquid storage container 20 through the pipeline, and the waste discharge end of thehemodialyzer 41 is communicated with the waste liquid bag 47 through the pipeline. Theliquid storage container 20, the firstperistaltic pump 46 and thehemodialyzer 41 form For the auxiliary circuit of filtering circulation, theleukocyte filter 57 is arranged on the main road of perfusion circulation or the auxiliary circuit of filtering circulation, and themicro-plug filter 44 is arranged on the main road of perfusion circulation or the auxiliary road of filtering circulation.

请参阅图16，进一步地，白细胞过滤器57设置于第一蠕动泵46与血液透析器41之间的管路上。Please refer to FIG. 16 , further, theleukocyte filter 57 is disposed on the pipeline between the firstperistaltic pump 46 and thehemodialyzer 41 .

请参阅图16，进一步地，离体器官灌注系统还包括第一压力传感器48与第二压力传感器49。第一压力传感器48设置于白细胞过滤器57的出液端或进液端，第二压力传感器49设置于膜肺42的出液端。如此，第一压力传感器48能相应感应到白细胞过滤器57的出液端或进液端的压力大小，并根据压力大小可以判断白细胞过滤器57是否出现堵塞，无需人为判断，自动化程度大大提高。需要说明的是，为了更好地判断白细胞过滤器57是否出现堵塞，在白细胞过滤器57的进液端与出液端均设有第一压力传感器48。Please refer to FIG. 16 , further, the isolated organ perfusion system further includes afirst pressure sensor 48 and asecond pressure sensor 49 . Thefirst pressure sensor 48 is arranged at the liquid outlet end or the inlet end of theleukocyte filter 57 , and thesecond pressure sensor 49 is arranged at the liquid outlet end of themembrane lung 42 . In this way, thefirst pressure sensor 48 can correspondingly sense the pressure of the liquid outlet end or the liquid inlet end of theleukocyte filter 57, and can judge whether theleukocyte filter 57 is blocked according to the pressure, without human judgment, and the degree of automation is greatly improved. It should be noted that, in order to better determine whether theleukocyte filter 57 is blocked, afirst pressure sensor 48 is provided on both the liquid inlet end and the liquid outlet end of theleukocyte filter 57 .

此外，第二压力传感器49能用于检测到膜肺42的灌注压力大小，因为人的肺部在呼吸过程中是有压力要求的，为了满足人真实呼吸的压力值，通过第二压力传感器49对膜肺42的出液端的灌注压力大小进行检测。如果膜肺42的出液端开始阶段的压力值正常，后面阶段的灌注压力值不正常，也可以评判这个肺的灌注效果好坏。In addition, thesecond pressure sensor 49 can be used to detect the perfusion pressure of themembrane lung 42, because the human lungs have pressure requirements during the breathing process. The perfusion pressure at the liquid outlet end of themembrane lung 42 is detected. If the pressure value of the liquid outlet end of themembrane lung 42 in the initial stage is normal, and the perfusion pressure value in the later stage is abnormal, the perfusion effect of the lung can also be judged.

请参阅图6、图8至图10，图8示意出了本发明一实施例中的离体器官灌注系统的储液容器20装设有第一压力传感器48与第二压力传感器49的结构示意图，图9示意出了图8在A处的放大结构示意图，图10示意出了本发明一实施例中的离体器官灌注系统的储液容器20未装设有第一压力传感器48与第二压力传感器49的结构示意图。进一步地，离体器官灌注系统还包括第一传感器夹具55与第二传感器夹具56。第一传感器夹具55装设于辅助安装壳30上或者装设于储液容器20的外侧壁上，第一压力传感器48可拆卸地装设于第一传感器夹具55上。第二传感器夹具56装设于储液容器20的外侧壁上，第二压力传感器49可拆卸地装设于第二传感器夹具56上。如此，第一压力传感器48与第二压力传感器49作为一次性耗材，便于进行拆卸安装及更换，操作方便。此外，第二压力传感器49由于装设于储液容器20的外侧壁上，也就是较为靠近于储液容器20内部的离体器官的动脉出口，使得检测到的灌注压力较为准确。Please refer to FIG. 6, FIG. 8 to FIG. 10. FIG. 8 is a schematic diagram showing the structure of theliquid storage container 20 of the isolated organ perfusion system in an embodiment of the present invention equipped with thefirst pressure sensor 48 and thesecond pressure sensor 49 , FIG. 9 shows the enlarged schematic view of FIG. 8 at A, FIG. 10 shows that theliquid storage container 20 of the isolated organ perfusion system in an embodiment of the present invention is not equipped with thefirst pressure sensor 48 and thesecond pressure sensor 48. A schematic diagram of the structure of thepressure sensor 49 . Further, the isolated organ perfusion system further includes afirst sensor fixture 55 and asecond sensor fixture 56 . Thefirst sensor fixture 55 is mounted on theauxiliary mounting shell 30 or on the outer side wall of theliquid storage container 20 , and thefirst pressure sensor 48 is detachably mounted on thefirst sensor fixture 55 . Thesecond sensor fixture 56 is mounted on the outer side wall of theliquid storage container 20 , and thesecond pressure sensor 49 is detachably mounted on thesecond sensor fixture 56 . In this way, thefirst pressure sensor 48 and thesecond pressure sensor 49 are disposable consumables, which are convenient for disassembly, installation and replacement, and are easy to operate. In addition, since thesecond pressure sensor 49 is installed on the outer side wall of theliquid storage container 20 , that is, closer to the arterial outlet of the isolated organ inside theliquid storage container 20 , the detected perfusion pressure is more accurate.

进一步地，第一传感器夹具55包括底板551及连接于底板551的相对两侧的两个L形限位板552。底板551装设于辅助安装壳30上或者装设于储液容器 20的外侧壁上，L形限位板552上设有条形口553，L形限位板552与第一压力传感器48的座板481限位配合以防止座板481在垂直于底板551板面的方向上移动，座板481能沿着底板551的板面滑动，座板481上设有与条形口553位置对应的安装孔482，座板481通过安装件穿过条形口553及安装孔482装设于 L形限位板552上。如此，第一压力传感器48能便于装设于第一传感器夹具55上，同时在第一传感器夹具55上的安装位置可调。Further, thefirst sensor fixture 55 includes abottom plate 551 and two L-shaped limitingplates 552 connected to opposite sides of thebottom plate 551 . Thebottom plate 551 is installed on theauxiliary installation shell 30 or installed on the outer side wall of theliquid storage container 20 , the L-shapedlimit plate 552 is provided with a strip-shapedopening 553 , and the L-shapedlimit plate 552 is connected to thefirst pressure sensor 48 . Theseat plate 481 is limited and matched to prevent theseat plate 481 from moving in the direction perpendicular to the surface of thebottom plate 551. Theseat plate 481 can slide along the plate surface of thebottom plate 551. The mountinghole 482 and theseat plate 481 are mounted on the L-shaped limitingplate 552 through thestrip opening 553 and the mountinghole 482 through the mounting piece. In this way, thefirst pressure sensor 48 can be easily installed on thefirst sensor fixture 55, and at the same time, the installation position on thefirst sensor fixture 55 can be adjusted.

此外，第二传感器夹具56的结构与第一传感器夹具55的结构相同，在此不进行赘述。由于第二压力传感器49在第二传感器夹具56上能调整高度位置，因此能实现第二压力传感器49的高度位置调整成与肺动脉的灌注入口的高度位置高度一致，使得检测较为准确。In addition, the structure of thesecond sensor fixture 56 is the same as that of thefirst sensor fixture 55 , and details are not described here. Since the height position of thesecond pressure sensor 49 can be adjusted on thesecond sensor fixture 56, the height position of thesecond pressure sensor 49 can be adjusted to be highly consistent with the height position of the perfusion inlet of the pulmonary artery, so that the detection is more accurate.

请再参阅图3及图7，在一个实施例中，辅助安装壳30的壁上设有第二锁扣结构31，外套包10的壁上设有与第二锁扣结构31对应的扣孔12，第二锁扣结构31设置于扣孔12中。如此，能便于将辅助安装壳30可拆卸地装设于外套包10中。Please refer to FIG. 3 and FIG. 7 again. In one embodiment, asecond locking structure 31 is provided on the wall of theauxiliary installation shell 30 , and a button hole corresponding to thesecond locking structure 31 is provided on the wall of theouter bag 10 . 12. Thesecond locking structure 31 is arranged in thebutton hole 12 . In this way, theauxiliary installation shell 30 can be easily detachably installed in theouter bag 10 .

请参阅图10，在一个实施例中，离体器官灌注系统还包括连通管61与液位传感器62。连通管61位于储液容器20外，连通管61的底端与储液容器20相连通，液位传感器62设置于连通管61上，液位传感器62用于获取连通管61 上的液位高度。如此，储液容器20内的灌注液通过连通管61的底端进入到连通管61，连通管61内的液位高度即为储液容器20的液位高度，由于储液容器 20的灌注液表面上的气泡无法进入到连通管61内，因此液位传感器62能较为准确地获取到连通管61内的液位高度，也就是能获取到储液容器20内的液位高度，从而能够较为准确地获取到储液容器20内的灌注液容量是否在预设范围。Referring to FIG. 10 , in one embodiment, the isolated organ perfusion system further includes acommunication pipe 61 and aliquid level sensor 62 . Thecommunication pipe 61 is located outside theliquid storage container 20, and the bottom end of thecommunication pipe 61 is communicated with theliquid storage container 20. Theliquid level sensor 62 is arranged on thecommunication pipe 61, and theliquid level sensor 62 is used to obtain the liquid level height on thecommunication pipe 61. . In this way, the perfusion liquid in theliquid storage container 20 enters thecommunication pipe 61 through the bottom end of thecommunication pipe 61, and the liquid level height in thecommunication pipe 61 is the liquid level height of theliquid storage container 20. Since the perfusion liquid in theliquid storage container 20 The air bubbles on the surface cannot enter thecommunication pipe 61, so theliquid level sensor 62 can more accurately obtain the liquid level height in thecommunication pipe 61, that is, the liquid level height in theliquid storage container 20 can be obtained more accurately. It is accurately obtained whether the volume of the perfusate in theliquid storage container 20 is within the preset range.

进一步地，液位传感器62为光感应器，光感应器设于连通管61外部，连通管61为透明管或半透明管。如此，液位传感器62无需与连通管61内的灌注液接触，不会导致污染灌注液，从而液位传感器62可以重复利用，不需要作为一次性耗材，使得装置成本降低。可以理解的是，液位传感器62还可以采用其它类型的传感器，例如超声波传感器，在此不进行限定。Further, theliquid level sensor 62 is a light sensor, and the light sensor is arranged outside thecommunication pipe 61 , and thecommunication pipe 61 is a transparent pipe or a translucent pipe. In this way, theliquid level sensor 62 does not need to be in contact with the perfusate in thecommunication pipe 61, and will not cause contamination of the perfusate, so theliquid level sensor 62 can be reused and does not need to be used as a disposable consumable, which reduces the cost of the device. It can be understood that theliquid level sensor 62 can also adopt other types of sensors, such as ultrasonic sensors, which are not limited herein.

进一步地，连通管61的顶端与储液容器20相连通；或者，连通管61的管壁上设有刻度线。如此，连通管61的顶端与储液容器20相连通后，储液容器 20内的灌注液不会通过连通管61的顶端向外排放。此外，连通管61的管壁上设置刻度线后，也可以通过刻度线观察储液容器20的液位高度，使用方便。Further, the top end of thecommunication pipe 61 is communicated with theliquid storage container 20; or, a scale line is provided on the pipe wall of thecommunication pipe 61. In this way, after the top end of thecommunication pipe 61 is communicated with theliquid storage container 20, the perfusion liquid in theliquid storage container 20 will not be discharged to the outside through the top end of thecommunication pipe 61. In addition, after the scale line is set on the pipe wall of thecommunication pipe 61, the liquid level height of theliquid storage container 20 can also be observed through the scale line, which is convenient to use.

请参阅图11至图13，图11示意出了本发明一实施例中的离体器官灌注系统的结构示意图，图12示意出了图11在B处的放大结构示意图，图13示意出了本发明一实施例中的离体器官灌注系统的剖开后的其中一部分结构示意图。进一步地，储液容器20的底壁中部部位向上隆起形成梯形凸台21，梯形凸台 21的顶面面积小于梯形凸台21的底面面积。如此，梯形凸台21的侧面与储液容器20的侧壁围成的空间区域的间隔宽度从上至下逐渐变窄，这样能实现储液容器20内的灌注液向外排放的过程中，灌注液逐渐汇聚于储液容器20的底部区域，并通过储液容器20底部的出液口22向外排放，排放效果较为完全，在储液容器20的底壁壁面上残留量较小。Please refer to FIG. 11 to FIG. 13. FIG. 11 shows a schematic structural diagram of an isolated organ perfusion system in an embodiment of the present invention, FIG. 12 shows an enlarged schematic structural diagram of FIG. A schematic structural diagram of a part of the cut-away organ perfusion system in an embodiment of the invention. Further, the middle part of the bottom wall of theliquid storage container 20 is raised upward to form atrapezoidal boss 21, and the top surface area of thetrapezoidal boss 21 is smaller than the bottom surface area of thetrapezoidal boss 21. In this way, the interval width of the space area enclosed by the side surface of thetrapezoidal boss 21 and the side wall of theliquid storage container 20 is gradually narrowed from top to bottom, so that in the process of discharging the perfusion liquid in theliquid storage container 20 to the outside, The perfusion liquid gradually converges on the bottom area of theliquid storage container 20 and is discharged outward through theliquid outlet 22 at the bottom of theliquid storage container 20 .

请参阅图14与图15，图14示意出了本发明一实施例中的离体器官灌注系统的剖开后的另一部分结构示意图，图15示意出了图14在C处的放大结构示意图。需要说明的是，储液容器20的底壁上通常设置有出液口22，出液口22 一般例如为两个，其中一个出液口22通过例如接头23与灌注循环主路的离心泵45相连，离心泵45工作时，将储液容器20内的灌注液通过其中一个出液口 22向外抽出；另一个出液口22通过例如接头23与过滤循环辅路的第一蠕动泵 46相连，第一蠕动泵46工作时，将储液容器20内的灌注液通过另一个出液口22向外抽出。灌注液通过出液口22向外抽出的过程中容易使得储液容器20中产生漩涡，进而导致灌注液中产生并混合有气泡，将对离体器官造成不利影响。Please refer to FIG. 14 and FIG. 15 , FIG. 14 shows another part of the cutaway structural schematic diagram of the isolated organ perfusion system in an embodiment of the present invention, and FIG. 15 shows the enlarged structural schematic diagram at C of FIG. 14 . It should be noted that the bottom wall of theliquid storage container 20 is usually provided with aliquid outlet 22. There are generally twoliquid outlets 22, for example, one of theliquid outlets 22 is connected to thecentrifugal pump 45 of the main perfusion circuit through, for example, the joint 23. When thecentrifugal pump 45 is working, the perfusion fluid in theliquid storage container 20 is drawn out through one of theliquid outlets 22; When the firstperistaltic pump 46 works, the perfusion liquid in theliquid storage container 20 is drawn out through the otherliquid outlet 22 . When the perfusate is drawn out through theliquid outlet 22, a vortex is easily generated in theliquid storage container 20, which in turn causes bubbles to be generated and mixed in the perfusate, which will adversely affect the isolated organ.

请参阅图13至图15，进一步地，离体器官灌注系统还包括导流架63。导流架63设置于储液容器20内并位于储液容器20的出液口22的上方。具体而言，导流架63在储液容器20的底壁上的投影覆盖出液口22。如此，在导流架 63的阻挡作用下，储液容器20上部处的灌注液不会直接通过储液容器20底部处的出液口22向外排放，这样能避免储液容器20中产生漩涡，也能有效抑制灌注液中产生气泡或混入空气。Please refer to FIG. 13 to FIG. 15 , further, the isolated organ perfusion system further includes aguide frame 63 . Theguide frame 63 is disposed in theliquid storage container 20 and is located above theliquid outlet 22 of theliquid storage container 20 . Specifically, the projection of theguide frame 63 on the bottom wall of theliquid storage container 20 covers theliquid outlet 22 . In this way, under the blocking action of theguide frame 63, the perfusion liquid at the upper part of theliquid storage container 20 will not be directly discharged outward through theliquid outlet 22 at the bottom of theliquid storage container 20, which can avoid the vortex generated in theliquid storage container 20. , It can also effectively inhibit the generation of air bubbles or air mixing in the perfusate.

请参阅图13至图15，在一个具体的实施例中，储液容器20的底壁中部部位向上隆起形成梯形凸台21，梯形凸台21的顶面面积小于梯形凸台21的底面面积，储液容器20的出液口22位于储液容器20的底壁外围部位。离体器官灌注系统还包括导流架63。导流架63设置于梯形凸台21的侧面与储液容器20的侧壁之间，导流架63位于储液容器20的出液口22的上方，导流架63与梯形凸台21的侧面之间或与储液容器20的侧壁之间设有间隙633。如此，在导流架 63的阻挡作用下，储液容器20上部处的灌注液不会直接通过储液容器20底部处的出液口22向外排放，而是通过间隙633进入到导流架63的下方区域并通过出液口22向外排放，这样能较好地避免储液容器20中产生漩涡，也能较好地有效抑制灌注液中产生气泡或混入空气。具体而言，导流架63包括顶板631 及位于顶板631两侧的脚板632，脚板632与储液容器20的底壁相连，两侧的脚板632支撑起顶板631，使得顶板631与储液容器20的底壁形成间隔。顶板 631位于储液容器20的出液口22的上方，顶板631避免储液容器20上部处的灌注液不会直接通过储液容器20底部处的出液口22向外排放，而是通过间隙 633进入到导流架63的下方区域并通过出液口22向外排放。Referring to FIGS. 13 to 15 , in a specific embodiment, the middle part of the bottom wall of theliquid storage container 20 is raised upward to form atrapezoidal boss 21 , and the top surface area of thetrapezoidal boss 21 is smaller than the bottom surface area of thetrapezoidal boss 21 . Theliquid outlet 22 of theliquid storage container 20 is located at the peripheral portion of the bottom wall of theliquid storage container 20 . The isolated organ perfusion system also includes aguide frame 63 . Theguide frame 63 is arranged between the side surface of thetrapezoidal boss 21 and the side wall of theliquid storage container 20 , and theguide frame 63 is located above theliquid outlet 22 of theliquid storage container 20 . Agap 633 is provided between the side surfaces or with the side wall of theliquid storage container 20 . In this way, under the blocking action of theguide frame 63, the perfusion liquid at the upper part of theliquid storage container 20 will not be discharged directly through theliquid outlet 22 at the bottom of theliquid storage container 20, but will enter the guide frame through thegap 633 63 and discharged to the outside through theliquid outlet 22, which can better avoid vortexes in theliquid storage container 20, and can effectively inhibit the generation of air bubbles or air mixing in the perfusion liquid. Specifically, theguide frame 63 includes atop plate 631 andfoot plates 632 located on both sides of thetop plate 631. Thefoot plates 632 are connected to the bottom wall of theliquid storage container 20, and thefoot plates 632 on both sides support thetop plate 631, so that thetop plate 631 is connected to the liquid storage container. The bottom wall of 20 forms the space. Thetop plate 631 is located above theliquid outlet 22 of theliquid storage container 20. Thetop plate 631 prevents the perfusion liquid at the upper part of theliquid storage container 20 from being discharged directly through theliquid outlet 22 at the bottom of theliquid storage container 20, but through the gap. 633 enters the lower area of theguide frame 63 and is discharged outward through theliquid outlet 22 .

请参阅图11，进一步地，离体器官灌注系统还包括第一盖体11。第一盖体 11可拆卸地设置于外套包10的口部，且第一盖体11位于辅助安装壳30的上方。Please refer to FIG. 11 , further, the isolated organ perfusion system further includes afirst cover 11 . Thefirst cover body 11 is detachably disposed at the mouth of theouter bag 10 , and thefirst cover body 11 is located above theauxiliary installation shell 30 .

请参阅图11，进一步地，离体器官灌注系统还包括支架24与第二盖体25。支架24设置于储液容器20的内壁上，支架24用于支撑放置离体器官。第二盖体25可打开地设置于储液容器20的口部。Please refer to FIG. 11 , further, the isolated organ perfusion system further includes abracket 24 and asecond cover 25 . Thebracket 24 is disposed on the inner wall of theliquid storage container 20, and thebracket 24 is used for supporting and placing the isolated organ. Thesecond cover 25 is openably provided at the mouth of theliquid storage container 20 .

需要说明的是，在侵权对比中，该“导流架63”可以为“储液容器20的一部分”，即“导流架63”与“储液容器20的其他部分”一体成型制造；也可以与“储液容器20的其他部分”可分离的一个独立的构件，即“导流架63”可以独立制造，再与“储液容器20的其他部分”组合成一个整体。It should be noted that, in the infringement comparison, the "guide frame 63" can be a "part of theliquid storage container 20", that is, the "guide frame 63" and the "other parts of theliquid storage container 20" are integrally formed; An independent component that can be separated from the "other parts of theliquid storage container 20", that is, the "guide frame 63" can be manufactured independently, and then combined with the "other parts of theliquid storage container 20" as a whole.

需要说明的是，在侵权对比中，该“支架24”可以为“储液容器20的一部分”，即“支架24”与“储液容器20的其他部分”一体成型制造；也可以与“储液容器20的其他部分”可分离的一个独立的构件，即“支架24”可以独立制造，再与“储液容器20的其他部分”组合成一个整体。It should be noted that, in the infringement comparison, the "support 24" can be a "part of theliquid storage container 20", that is, the "support 24" and the "other parts of theliquid storage container 20" are integrally formed; The other part of theliquid container 20 "is a separable independent component, that is, the "support 24" can be manufactured independently, and then combined with the "other part of theliquid storage container 20" into a whole.

需要说明的是，灌注液例如是低分子右旋糖苷-40、氯化钠、氯化钾、氯化钙、葡萄糖等混合溶液，灌注液的具体成分在此不进行限定。It should be noted that the perfusate is, for example, a mixed solution of low molecular weight dextran-40, sodium chloride, potassium chloride, calcium chloride, and glucose, and the specific components of the perfusate are not limited here.

此外，灌注液在灌注循环主路中循环流动时，能实现持续向离体器官灌注灌注液，以在常温环境下实现离体器官的长时间保存，进而有效避免低温环境所带来的诸如组织细胞受到损害、器官缺血等问题；同时，通过动力泵驱动灌注液循环流动，能够有效去除离体器官中的血栓、炎症因子或其他异物有害物质，进而可维持离体器官的功能血管通畅，从而可改善诸如肺水肿、提高心肺氧合能力等，并可以以对离体器官进行修复治疗，降低术后移植物失功的风险，有效提升离体器官的利用率以及移植手术的成功率。In addition, when the perfusate circulates in the main circuit of the perfusion cycle, it can continuously perfuse the isolated organ with the perfusate, so as to realize the long-term preservation of the isolated organ in the normal temperature environment, thereby effectively avoiding the tissue damage caused by the low temperature environment. Cell damage, organ ischemia and other problems; at the same time, by driving the circulation of perfusate through the power pump, it can effectively remove thrombus, inflammatory factors or other foreign harmful substances in the isolated organ, thereby maintaining the functional blood vessels of the isolated organ. As a result, it can improve pulmonary edema, improve cardiopulmonary oxygenation capacity, etc., and can repair isolated organs, reduce the risk of postoperative graft failure, and effectively improve the utilization rate of isolated organs and the success rate of transplantation.

另外，补液袋65的液体用于补充所需并且被离体器官消耗的微量物质，例如钠元素、钾元素等等，在此不进行限定。In addition, the liquid in therehydration bag 65 is used to supplement the trace substances required and consumed by the isolated organs, such as sodium element, potassium element, etc., which are not limited herein.

上述的离体器官灌注系统，在离心泵45的动力作用下，能实现储液容器20 中的灌注液经过膜肺42进入到离体器官中，并由离体器官循环流回到储液容器 20中。在第一蠕动泵46的动力作用下，能实现储液容器20中的灌注液经过血液透析器41进行过滤处理，灌注液经过血液透析器41过滤处理后，能实现滤除掉颗粒物、重金属等杂质；其中，由于在过滤循环辅路上设置有白细胞过滤器57，如此一方面，白细胞过滤器57能过滤掉灌注液中的白细胞，有效减少离体器官因进行灌注液灌注而发生的损伤，同时可有效延缓器官移植排异反应发生，进一步提升供体器官的利用率以及移植手术的成功率，另一方面，由于白细胞过滤器57设置于过滤循环辅路上，而并非设置于灌注循环主路上，这样白细胞过滤器57因为长时间工作(例如10小时)而导致堵塞时，白细胞过滤器 57会导致过滤循环辅路发生堵塞，而并不会导致灌注循环主路发生堵塞，此时灌注循环主路仍然可以继续工作，能持续对离体器官起到保护作用，并及时更换过滤循环辅路上的白细胞过滤器57即可。The above-mentioned isolated organ perfusion system, under the power of thecentrifugal pump 45, can realize that the perfusate in theliquid storage container 20 enters the isolated organ through themembrane lung 42, and flows back to the liquid storage container by the isolated organ circulatory. 20. Under the power of the firstperistaltic pump 46 , the perfusate in theliquid storage container 20 can be filtered through thehemodialyzer 41 , and after the perfusate has been filtered by thehemodialyzer 41 , particulate matter, heavy metals, etc. can be filtered out. Impurities; among them, because theleukocyte filter 57 is arranged on the auxiliary circuit of the filtration circulation, on the one hand, theleukocyte filter 57 can filter out the leukocytes in the perfusate, effectively reducing the damage to the isolated organs due to the perfusion of the perfusate, and at the same time It can effectively delay the occurrence of organ transplantation rejection, and further improve the utilization rate of donor organs and the success rate of transplantation. In this way, when theleukocyte filter 57 is blocked due to long-term operation (for example, 10 hours), theleukocyte filter 57 will cause the filtration circulation auxiliary circuit to be blocked, but will not cause the perfusion circulation main circuit to be blocked. At this time, the perfusion circulation main circuit is still It can continue to work, can continue to protect the isolated organs, and theleukocyte filter 57 on the filtering circulation auxiliary road can be replaced in time.

请参阅图16，进一步地，微栓过滤器44设置于灌注循环主路上或设置于过滤循环辅路上。如此，微栓过滤器44用于滤除灌注液中的各种微栓，防止因血栓或气栓等各种微栓而造成离体器官的微血管的栓塞，有效地改善人体微血管的血液灌注，进一步提升供体器官的利用率以及移植手术的成功率。Please refer to FIG. 16 , further, themicro-plug filter 44 is disposed on the main circuit of the perfusion cycle or on the auxiliary circuit of the filtration cycle. In this way, themicro-embolism filter 44 is used to filter out various micro-emboli in the perfusate, to prevent the embolism of the micro-vessel of the isolated organ caused by various micro-embolism such as thrombus or air embolism, and to effectively improve the blood perfusion of the human body's micro-vessel. Further improve the utilization rate of donor organs and the success rate of transplant operations.

请参阅图16，更进一步地，微栓过滤器44设置于离心泵45与膜肺42之间的管路上。如此，离心泵45流出的灌注液经过微栓过滤器44过滤微栓后，再进入到膜肺42中，这样能避免微栓进入到膜肺42中而导致膜肺42出现堵塞现象。Please refer to FIG. 16 , further, themicro-plug filter 44 is disposed on the pipeline between thecentrifugal pump 45 and themembrane lung 42 . In this way, the perfusate flowed out of thecentrifugal pump 45 is filtered by themicroembolism filter 44 and then enters themembrane lung 42 , which can prevent the microembolism from entering themembrane lung 42 and causing themembrane lung 42 to block.

请参阅图16，进一步地，白细胞过滤器57设置于第一蠕动泵46与血液透析器41之间的管路上。如此，白细胞过滤器57的设置位置较为合理，因为在白细胞过滤器57发生堵塞时，灌注液不会再进入到血液透析器41中并对血液透析器41造成不良影响，此外第一蠕动泵46仍然能够提供动力推动灌注液向前运行。当然，可选地，白细胞过滤器57也可以设置于储液容器20流向第一蠕动泵46的管路上，或者血液透析器41回流到储液容器20的管路上。Please refer to FIG. 16 , further, theleukocyte filter 57 is disposed on the pipeline between the firstperistaltic pump 46 and thehemodialyzer 41 . In this way, the setting position of theleukocyte filter 57 is more reasonable, because when theleukocyte filter 57 is blocked, the perfusate will not enter thehemodialyzer 41 again and cause adverse effects on thehemodialyzer 41. In addition, the firstperistaltic pump 46 Still able to provide power to push the perfusate forward. Of course, optionally, theleukocyte filter 57 can also be provided on the pipeline of theliquid storage container 20 flowing to the firstperistaltic pump 46 , or the pipeline of thehemodialyzer 41 returning to theliquid storage container 20 .

请参阅图16，进一步地，离体器官灌注系统还包括第一开关阀64。第一开关阀64与白细胞过滤器57均为两个以上，两个以上白细胞过滤器57并联设置于过滤循环辅路上，两个以上第一开关阀64与两个以上白细胞过滤器57一一对应设置，第一开关阀64用于控制其对应的白细胞过滤器57是否接入到过滤循环辅路中。具体在本实施例中，白细胞过滤器57为两个，其中一个包细胞过滤器接入到过滤循环辅路时，其对应的第一开关阀64处于打开状态，另一个白细胞过滤器57不接入到过滤循环辅路，另一个白细胞过滤器57对应的第一开关阀64处于关闭状态。当其中一个白细胞过滤器57出现堵塞时，关掉其对应的第一开关阀64，并打开另一个白细胞过滤器57对应的第一开关阀64，使得另一个白细胞过滤器57接入到过滤循环辅路，此时过滤循环辅路仍然可以发挥循环过滤灌注液的功能。Referring to FIG. 16 , further, the isolated organ perfusion system further includes a first on-offvalve 64 . There are two or more first on-offvalves 64 and more than twoleukocyte filters 57 , two or more leukocyte filters 57 are arranged in parallel on the filtration circulation auxiliary road, and two or more first on-offvalves 64 are in one-to-one correspondence with more than twoleukocyte filters 57 It is configured that the first on-offvalve 64 is used to control whether the corresponding whiteblood cell filter 57 is connected to the auxiliary filter circuit. Specifically, in this embodiment, there are two leukocyte filters 57 . When one leukocyte filter is connected to the filtration circulation auxiliary circuit, its correspondingfirst switch valve 64 is in an open state, and theother leukocyte filter 57 is not connected. To the filtration circulation auxiliary circuit, thefirst switch valve 64 corresponding to theother leukocyte filter 57 is in a closed state. When one of the leukocyte filters 57 is blocked, the correspondingfirst switch valve 64 is closed, and thefirst switch valve 64 corresponding to theother leukocyte filter 57 is opened, so that theother leukocyte filter 57 is connected to the filtration cycle At this time, the filtering and circulating auxiliary circuit can still play the function of circulating and filtering the perfusate.

请参阅图16，进一步地，第一开关阀64为用于控制白细胞过滤器57所在支路的开度大小的电动夹管阀或手动夹管阀。如此，电动夹管阀或手动夹管阀夹持于白细胞过滤器57所在支路上，通过控制支路的开度大小来控制白细胞过滤器57所在支路的流量大小以及白细胞过滤器57所在支路是否接入到过滤循环辅路中。另外，电动夹管阀或手动夹管阀均不会接触到灌注液，从而能避免污染灌注液，并能进行循环利用，不必做成一次性耗材。Please refer to FIG. 16 , further, the first on-offvalve 64 is an electric pinch valve or a manual pinch valve for controlling the opening degree of the branch where theleukocyte filter 57 is located. In this way, the electric pinch valve or the manual pinch valve is clamped on the branch where theleukocyte filter 57 is located, and the flow rate of the branch where theleukocyte filter 57 is located and the branch where theleukocyte filter 57 is located are controlled by controlling the opening of the branch. Whether it is connected to the filter loop auxiliary circuit. In addition, neither the electric pinch valve nor the manual pinch valve will come into contact with the perfusate, which can avoid contamination of the perfusate, and can be recycled without having to make disposable consumables.

在一个实施例中，第一压力传感器48为两个以上，两个以上第一压力传感器48与两个以上白细胞过滤器57一一对应并串联设置。如此，第一压力传感器48能相应感应到其对应的白细胞过滤器57所在支路上的压力大小，并根据压力大小可以判断对应的白细胞过滤器57是否出现堵塞，无需人为判断，自动化程度大大提高。In one embodiment, there are more than twofirst pressure sensors 48 , and the two or morefirst pressure sensors 48 are in one-to-one correspondence with more than twoleukocyte filters 57 and are arranged in series. In this way, thefirst pressure sensor 48 can correspondingly sense the pressure on the branch where thecorresponding leukocyte filter 57 is located, and can judge whether thecorresponding leukocyte filter 57 is blocked according to the pressure, without human judgment, and the degree of automation is greatly improved.

在一个实施例中，控制器分别与第一压力传感器48、第一开关阀64电性连接。如此，当控制器根据第一压力传感器48判断到第一压力传感器48对应的白细胞过滤器57出现堵塞时，控制器控制另一个第一开关阀64打开，将另一个第一开关阀64所在的支路开通接入到过滤循环辅路中。In one embodiment, the controller is electrically connected to thefirst pressure sensor 48 and thefirst switch valve 64, respectively. In this way, when the controller determines that theleukocyte filter 57 corresponding to thefirst pressure sensor 48 is blocked according to thefirst pressure sensor 48, the controller controls the otherfirst switch valve 64 to open, and switches the location where the otherfirst switch valve 64 is located. The branch circuit is opened and connected to the filtering circulation auxiliary circuit.

在一个实施例中，离体器官灌注系统还包括补液袋65与第二开关阀66。补液袋65通过管路与储液容器20相连通，第二开关阀66设置于补液袋65连接到储液容器20的管路上，液位传感器62用于获取储液容器20的液位高度，第二开关阀66、液位传感器62均与控制器电性连接。如此，控制器根据液位传感器62感应到储液容器20的液位高度信息相应控制第二开关阀66的开度大小，从而控制补液袋65给储液容器20的补液速度及补液量大小，使得储液容器20 内的灌注液体积维持平衡。具体而言，第二开关阀66例如为电动夹管阀。电动夹管阀夹持于补液袋65连接到储液容器20的管路上，通过控制开度大小来控制补液袋65的补液流量大小。另外，电动夹管阀不会接触到补给液，从而能避免污染补给液，并能进行循环利用，不必做成一次性耗材。In one embodiment, the isolated organ perfusion system further includes afluid replacement bag 65 and a second on-offvalve 66 . Therehydration bag 65 is communicated with theliquid storage container 20 through a pipeline, the second on-offvalve 66 is arranged on the pipeline connecting therehydration bag 65 to theliquid storage container 20, and theliquid level sensor 62 is used to obtain the liquid level height of theliquid storage container 20, The second on-offvalve 66 and theliquid level sensor 62 are both electrically connected to the controller. In this way, the controller correspondingly controls the opening degree of the second on-offvalve 66 according to the liquid level height information of theliquid storage container 20 sensed by theliquid level sensor 62, thereby controlling the liquid replenishment speed and the liquid replenishment amount of theliquid replenishment bag 65 to theliquid storage container 20, The volume of perfusate in thereservoir 20 is maintained in equilibrium. Specifically, the second on-offvalve 66 is, for example, an electric pinch valve. The electric pinch valve is clamped on the pipeline connecting thefluid replacement bag 65 to thefluid storage container 20, and the fluid replacement flow of thefluid replacement bag 65 is controlled by controlling the opening degree. In addition, the electric pinch valve does not come into contact with the make-up fluid, so as to avoid contamination of the make-up fluid, and it can be recycled without having to make disposable consumables.

在一个实施例中，PH监测仪43与控制器电性连接，PH监测仪43用于获取灌注液的PH值。PH监测仪43既可以设置于灌注循环主路上，又可以设置于过滤循环辅路上，在此不进行限定。此外，PH监测仪43可以在线实时监测灌注液的PH情况，替代了人工检测，自动化程度较高。In one embodiment, thepH monitor 43 is electrically connected to the controller, and thepH monitor 43 is used to obtain the pH value of the perfusate. The pH monitor 43 can be installed on both the main road of the perfusion cycle and the auxiliary road of the filtration cycle, which is not limited here. In addition, the pH monitor 43 can monitor the pH of the perfusate in real time online, instead of manual detection, and has a high degree of automation.

可选地，当PH监测仪43检测到灌注液的PH值减小并小于预设范围时，在补液袋65中增加PH调节液，使得提高灌注液的PH值。Optionally, when thepH monitor 43 detects that the pH value of the perfusate decreases and is smaller than the preset range, a pH adjustment solution is added to thefluid replacement bag 65 to increase the pH value of the perfusate.

请参阅图16，可选地，离体器官灌注装置还包括调节液袋(未示意出)，调节液袋中装设有PH调节液，调节液袋通过管路与储液容器20相连通。在调节液袋连接到储液容器20的管路上设有第三开关阀(未示意出)，第三开关阀与控制器电性连接。当PH监测仪43检测到灌注液的PH值减小并小于预设范围时，控制器相应控制第三开关阀动作，调节液袋内的PH调节液输送到储液容器 20中，以增大灌注液的PH值并维持灌注液的PH值为预设范围。反之，当PH监测仪43检测到灌注液的PH值增大并大于预设范围时，控制器相应控制第三开关阀关闭，不进行补液。Please refer to FIG. 16 , optionally, the isolated organ perfusion device further includes a regulating fluid bag (not shown), the regulating fluid bag is filled with pH regulating fluid, and the regulating fluid bag is communicated with thefluid storage container 20 through a pipeline. A third on-off valve (not shown) is provided on the pipeline connecting the adjusting liquid bag to theliquid storage container 20, and the third on-off valve is electrically connected with the controller. When thepH monitor 43 detects that the pH value of the perfusate decreases and is smaller than the preset range, the controller controls the action of the third switch valve accordingly, and adjusts the pH adjustment solution in the liquid bag to be delivered to theliquid storage container 20 to increase the pH of the perfusate and maintain the pH of the perfusate within a preset range. On the contrary, when thepH monitor 43 detects that the pH value of the perfusate increases and is larger than the preset range, the controller controls the third switch valve to close accordingly and does not perform fluid supplementation.

在一个实施例中，膜肺42上设有用于与混合气源(附图中并未示出)管路连通的混合气接口。灌注液在膜肺42中与混合气结合形成氧合灌注液，以保证流入动脉的灌注液的氧含量充足。此外，膜肺42通过换热管与换热装置连通形成循环换热回路，灌注液在膜肺42内与循环换热回路的换热介质进行热交换，以保持灌注液的温度与离体器官相适宜。In one embodiment, themembrane lung 42 is provided with a mixed gas port for communicating with a mixed gas source (not shown in the drawings) pipeline. The perfusate is combined with the gas mixture in themembrane lung 42 to form an oxygenated perfusate to ensure sufficient oxygen content of the perfusate flowing into the arteries. In addition, themembrane lung 42 communicates with the heat exchange device through a heat exchange tube to form a circulating heat exchange circuit, and the perfusate exchanges heat with the heat exchange medium of the circulating heat exchange circuit in themembrane lung 42 to maintain the temperature of the perfusate and the isolated organ. Appropriate.

在一个实施例中，离体器官灌注系统还包括第二蠕动泵67。第二蠕动泵67 设置于血液透析器41的排废端与废液袋47之间的管路上。第二蠕动泵67能提供足够动力促使血液透析器41内的废液排出到废液袋47中，避免血液滤过器因压力差不够导致废液排泄不畅。In one embodiment, the isolated organ perfusion system further includes a secondperistaltic pump 67 . The secondperistaltic pump 67 is disposed on the pipeline between the waste end of thehemodialyzer 41 and the waste bag 47 . The secondperistaltic pump 67 can provide sufficient power to discharge the waste fluid in thehemodialyzer 41 into the waste fluid bag 47 , so as to avoid poor drainage of the waste fluid due to insufficient pressure difference of the hemodialyzer.

在一个实施例中，离体器官灌注系统还包括第一温度传感器68与第二温度传感器69。第一温度传感器68设置于膜肺42连接到离体器官的管路上，第一温度传感器68用于获取膜肺42的出液端处的温度大小。此外，第二温度传感器69设置于储液容器20上，用于获取储液容器20内的灌注液温度大小。另外，离体器官灌注系统还包括流量传感器70。流量传感器70设置于离心泵45与微栓过滤器44之间的管路上，流量传感器70能获取到离心泵45与微栓过滤器44 之间的管路上的灌注液的流量大小，并根据该流量大小可以判断出离心泵45、微栓过滤器44、膜肺42是否正常工作。此外，流量传感器70还能用于控制离心泵45的转速，保证离心泵45的转速为预设范围。In one embodiment, the isolated organ perfusion system further includes afirst temperature sensor 68 and a second temperature sensor 69 . Thefirst temperature sensor 68 is disposed on the pipeline connecting themembrane lung 42 to the isolated organ, and thefirst temperature sensor 68 is used to obtain the temperature at the liquid outlet end of themembrane lung 42 . In addition, the second temperature sensor 69 is disposed on theliquid storage container 20 for acquiring the temperature of the perfusate in theliquid storage container 20 . Additionally, the isolated organ perfusion system further includes aflow sensor 70 . Theflow sensor 70 is arranged on the pipeline between thecentrifugal pump 45 and themicro-plug filter 44, and theflow sensor 70 can obtain the flow rate of the perfusate on the pipeline between thecentrifugal pump 45 and themicro-plug filter 44, and according to this The flow rate can determine whether thecentrifugal pump 45, themicroembolizer filter 44, and themembrane lung 42 work normally. In addition, theflow sensor 70 can also be used to control the rotational speed of thecentrifugal pump 45 to ensure that the rotational speed of thecentrifugal pump 45 is within a preset range.

以上所述实施例的各技术特征可以进行任意的组合，为使描述简洁，未对上述实施例中的各个技术特征所有可能的组合都进行描述，然而，只要这些技术特征的组合不存在矛盾，都应当认为是本说明书记载的范围。The technical features of the above-described embodiments can be combined arbitrarily. For the sake of brevity, all possible combinations of the technical features in the above-described embodiments are not described. However, as long as there is no contradiction between the combinations of these technical features, All should be regarded as the scope described in this specification.

以上所述实施例仅表达了本发明的几种实施方式，其描述较为具体和详细，但并不能因此而理解为对发明专利范围的限制。应当指出的是，对于本领域的普通技术人员来说，在不脱离本发明构思的前提下，还可以做出若干变形和改进，这些都属于本发明的保护范围。因此，本发明专利的保护范围应以所附权利要求为准。The above-mentioned embodiments only represent several embodiments of the present invention, and the descriptions thereof are more specific and detailed, but should not be construed as a limitation on the scope of the invention patent. It should be noted that, for those skilled in the art, without departing from the concept of the present invention, several modifications and improvements can be made, which all belong to the protection scope of the present invention. Therefore, the protection scope of the patent of the present invention should be subject to the appended claims.

在本发明的描述中，需要理解的是，术语“中心”、“纵向”、“横向”、“长度”、“宽度”、“厚度”、“上”、“下”、“前”、“后”、“左”、“右”、“竖直”、“水平”、“顶”、“底”、“内”、“外”、“顺时针”、“逆时针”、“轴向”、“径向”、“周向”等指示的方位或位置关系为基于附图所示的方位或位置关系，仅是为了便于描述本发明和简化描述，而不是指示或暗示所指的装置或元件必须具有特定的方位、以特定的方位构造和操作，因此不能理解为对本发明的限制。In the description of the present invention, it should be understood that the terms "center", "longitudinal", "lateral", "length", "width", "thickness", "upper", "lower", "front", " Back, Left, Right, Vertical, Horizontal, Top, Bottom, Inner, Outer, Clockwise, Counterclockwise, Axial , "radial", "circumferential" and other indicated orientations or positional relationships are based on the orientations or positional relationships shown in the accompanying drawings, and are only for the convenience of describing the present invention and simplifying the description, rather than indicating or implying the indicated device or Elements must have a particular orientation, be constructed and operate in a particular orientation and are therefore not to be construed as limitations of the invention.

此外，术语“第一”、“第二”仅用于描述目的，而不能理解为指示或暗示相对重要性或者隐含指明所指示的技术特征的数量。由此，限定有“第一”、“第二”的特征可以明示或者隐含地包括至少一个该特征。在本发明的描述中，“多个”的含义是至少两个，例如两个，三个等，除非另有明确具体的限定。In addition, the terms "first" and "second" are only used for descriptive purposes, and should not be construed as indicating or implying relative importance or implying the number of indicated technical features. Thus, a feature delimited with "first", "second" may expressly or implicitly include at least one of that feature. In the description of the present invention, "plurality" means at least two, such as two, three, etc., unless otherwise expressly and specifically defined.

在本发明中，除非另有明确的规定和限定，术语“安装”、“相连”、“连接”、“固定”等术语应做广义理解，例如，可以是固定连接，也可以是可拆卸连接，或成一体；可以是机械连接，也可以是电连接；可以是直接相连，也可以通过中间媒介间接相连，可以是两个元件内部的连通或两个元件的相互作用关系，除非另有明确的限定。对于本领域的普通技术人员而言，可以根据具体情况理解上述术语在本发明中的具体含义。In the present invention, unless otherwise expressly specified and limited, the terms "installed", "connected", "connected", "fixed" and other terms should be understood in a broad sense, for example, it may be a fixed connection or a detachable connection , or integrated; it can be a mechanical connection or an electrical connection; it can be directly connected or indirectly connected through an intermediate medium, it can be the internal connection of two elements or the interaction relationship between the two elements, unless otherwise specified limit. For those of ordinary skill in the art, the specific meanings of the above terms in the present invention can be understood according to specific situations.

在本发明中，除非另有明确的规定和限定，第一特征在第二特征“上”或“下”可以是第一和第二特征直接接触，或第一和第二特征通过中间媒介间接接触。而且，第一特征在第二特征“之上”、“上方”和“上面”可是第一特征在第二特征正上方或斜上方，或仅仅表示第一特征水平高度高于第二特征。第一特征在第二特征“之下”、“下方”和“下面”可以是第一特征在第二特征正下方或斜下方，或仅仅表示第一特征水平高度小于第二特征。In the present invention, unless otherwise expressly specified and limited, a first feature "on" or "under" a second feature may be in direct contact between the first and second features, or the first and second features indirectly through an intermediary touch. Also, the first feature being "above", "over" and "above" the second feature may mean that the first feature is directly above or obliquely above the second feature, or simply means that the first feature is level higher than the second feature. The first feature being "below", "below" and "below" the second feature may mean that the first feature is directly below or obliquely below the second feature, or simply means that the first feature has a lower level than the second feature.

需要说明的是，当元件被称为“固定于”或“设置于”另一个元件，它可以直接在另一个元件上或者也可以存在居中的元件。当一个元件被认为是“连接”另一个元件，它可以是直接连接到另一个元件或者可能同时存在居中元件。本文所使用的术语“垂直的”、“水平的”、“上”、“下”、“左”、“右”以及类似的表述只是为了说明的目的，并不表示是唯一的实施方式。It should be noted that when an element is referred to as being "fixed to" or "disposed on" another element, it can be directly on the other element or an intervening element may also be present. When an element is referred to as being "connected" to another element, it can be directly connected to the other element or intervening elements may also be present. The terms "vertical", "horizontal", "upper", "lower", "left", "right" and similar expressions used herein are for the purpose of illustration only and do not represent the only embodiment.

Claims (10)

1. An ex vivo organ perfusion system, comprising:

the blood dialyzer comprises an outer sleeve package, a liquid storage container, an auxiliary installation shell, a hemodialyzer and a membrane lung, wherein the liquid storage container is arranged in the outer sleeve package, the liquid storage container is used for installing perfusate, the auxiliary installation shell is detachably arranged in the outer sleeve package, and the hemodialyzer and the membrane lung are detachably arranged in the auxiliary installation shell.

2. The isolated organ perfusion system of claim 1, further comprising a PH monitor, a micro-plug filter, and a leukocyte filter, wherein the PH monitor, the micro-plug filter, and the leukocyte filter are removably mounted in the auxiliary mounting housing.

3. The isolated organ perfusion system of claim 2, further comprising first, second, third, fourth, and fifth clamps disposed on the auxiliary mounting housing; the hemodialyzer is detachably arranged on the first clamp, the membrane lung is detachably arranged on the second clamp, the pH monitor is detachably arranged on the third clamp, the micro-suppository filter is detachably arranged on the fourth clamp, and the leukocyte filter is detachably arranged on the fifth clamp.

4. The isolated organ perfusion system of claim 3, wherein the first clamp comprises two first clamping plates oppositely disposed on the auxiliary mounting housing, the first clamping plates having first arcuate surfaces conforming to the side walls of the hemodialyzer; the second clamp comprises two second clamping plates which are oppositely arranged on the auxiliary mounting shell, and the second clamping plates are provided with second arc-shaped surfaces which are matched with the side walls of the membrane lungs; the third clamp comprises two third clamping plates which are oppositely arranged on the auxiliary mounting shell, and the third clamping plates are provided with third arc-shaped surfaces which are matched with the side walls of the PH monitor; fourth anchor clamps including set up in backup pad on the supplementary installation shell, be equipped with relative and coaxial two arc holes in the backup pad, and with the via hole of the tip correspondence intercommunication in arc hole, two first latch structures and two on the micro-bolt filter bottom surface the via hole one-to-one sets up, first latch structure can pass the via hole can along the arc hole removes, the buckle area size of first latch structure is greater than the width in arc hole.

5. The ex-vivo organ perfusion system according to claim 2, further comprising a centrifugal pump, a first peristaltic pump, and a waste fluid bag; the liquid inlet end of the centrifugal pump is communicated with the liquid storage container through a pipeline, the liquid outlet end of the centrifugal pump is communicated with the liquid inlet end of the membrane lung through a pipeline, the liquid outlet end of the membrane lung is used for being connected with an isolated organ through a pipeline, and the liquid storage container, the centrifugal pump, the membrane lung and the isolated organ form a perfusion circulation main path;

the liquid inlet end of the first peristaltic pump is communicated with the liquid storage container through a pipeline, the liquid outlet end of the first peristaltic pump is communicated with the liquid inlet end of the hemodialyzer through a pipeline, the liquid outlet end of the hemodialyzer is communicated with the liquid storage container through a pipeline, the waste discharge end of the hemodialyzer is communicated with the waste liquid bag through a pipeline, the liquid storage container, the first peristaltic pump and the hemodialyzer form a filtration circulation auxiliary path, the leukocyte filter is arranged on the perfusion circulation main path or the filtration circulation auxiliary path, and the micro-suppository filter is arranged on the perfusion circulation main path or on the filtration circulation auxiliary path.

6. The isolated organ perfusion system of claim 5, wherein the leukocyte cell filter is disposed on tubing between the first peristaltic pump and the hemodialyzer.

7. The isolated organ perfusion system of claim 5, further comprising a first pressure sensor disposed at the outlet or inlet end of the leukocyte filter, and a second pressure sensor disposed at the outlet end of the membrane lung.

8. The ex vivo organ perfusion system of claim 7, further comprising a first sensor clamp and a second sensor clamp; the first sensor clamp is arranged on the auxiliary mounting shell or the outer side wall of the liquid storage container, and the first pressure sensor is detachably arranged on the first sensor clamp; the second sensor clamp is arranged on the outer side wall of the liquid storage container, and the second pressure sensor is detachably arranged on the second sensor clamp.

9. The isolated organ perfusion system of claim 8, wherein the first sensor clamp comprises a base plate and two L-shaped limiting plates connected to opposite sides of the base plate; the bottom plate is arranged on the auxiliary mounting shell or on the outer side wall of the liquid storage container, a strip-shaped opening is formed in the L-shaped limiting plate, the L-shaped limiting plate is in limiting fit with the seat plate of the first pressure sensor to prevent the seat plate from moving in the direction perpendicular to the surface of the bottom plate, the seat plate can slide along the surface of the bottom plate, a mounting hole corresponding to the strip-shaped opening is formed in the seat plate, and the seat plate penetrates through the strip-shaped opening through a mounting piece and is arranged on the L-shaped limiting plate.

10. The isolated organ perfusion system according to any one of claims 1-9, wherein a second locking structure is provided on a wall of the auxiliary mounting housing, a locking hole corresponding to the second locking structure is provided on a wall of the outer sheath, and the second locking structure is provided in the locking hole;

the isolated organ perfusion system further comprises a support and a second cover body, the support is arranged on the inner wall of the liquid storage container, and the support is used for supporting and placing an isolated organ; the second cover body is arranged at the opening part of the liquid storage container in an openable way;

isolated organ perfusion system still includes communicating pipe and level sensor, communicating pipe is located outside the stock solution container, the bottom of communicating pipe with the stock solution container is linked together, level sensor set up in communicating pipe is last, level sensor is used for acquireing liquid level height on communicating pipe.

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