Disclosure of Invention
Therefore, it is necessary to provide a simulated ablation system and a method for a tumor therapeutic apparatus, which aim at the problem of low accuracy of tumor ablation region selected by the conventional simulation system.
In order to achieve the above object, an embodiment of the present invention provides a simulated ablation system for a tumor therapeutic apparatus, including a graph generation module, a region generation module, and a region processing module connected to the graph generation module and the region generation module;
the image generation module acquires the size of the tumor, generates a tumor contour image on a plane coordinate system according to the size of the tumor, and generates an ablatable region corresponding to the tumor contour image according to the size of the tumor and a preset safety interval;
the region generation module adds a simulation probe set on the tumor contour graph, applies voltage to the simulation probe set, processes the voltage based on the contour graph, and generates an initial ablation region on a plane coordinate system;
when the area processing module confirms that the initial ablation area falls into the ablation area, judging whether the initial ablation area covers the tumor contour graph or not; if yes, confirming that the simulated ablation is finished; if not, moving the simulation probe set and/or adjusting the voltage by a preset stepping value until the initial ablation area covers the tumor contour graph.
In one embodiment, the graph generation module processes the tumor length and the tumor width based on an ellipse model to obtain a tumor contour graph; wherein the tumor size includes tumor length and tumor width.
In one embodiment, the predetermined safety interval is in a range of 0.5 cm to 1 cm; the ablatable region completely covers the tumor contour pattern.
In one embodiment, the region generation module models the voltage to obtain a Laplace equation and solving conditions thereof, the Laplace equation is solved to obtain a potential distribution model corresponding to the voltage, and the potential distribution model is processed based on a field intensity potential relation to obtain an electric field intensity distribution model; and processing the electric field intensity distribution model based on a contour line drawing algorithm to obtain an initial ablation region.
In one embodiment, the set of mimetic probes comprises at least one set of mimetic probe pairs; the analog probe pair includes at least one analog probe.
In one embodiment, the area generation module sequentially adds each analog probe pair to the tumor contour graph and applies a voltage to each analog probe pair; and sequentially processing the voltages of the corresponding simulated probe pairs based on the contour graph, and generating initial ablation sub-regions at corresponding positions of the corresponding simulated probe pairs.
In one embodiment, the region generation module combines the initial ablation sub-regions that satisfy the overlaid tumor contour graph and fall within the ablatable region, resulting in an initial ablation region.
In one embodiment, the area processing module moves the simulation probe set until the overlap area of the initial ablation area and the tumor outline graph is the largest, and the overlap area of the initial ablation area and the ablatable area is the largest; the voltage is increased or decreased by a preset step value until the initial ablation region overlays the tumor contour pattern and falls within the ablatable region.
In one embodiment, the display module further comprises a connection area processing module:
the display module displays a tumor contour graph, an ablatable region, and an initial ablation region.
On the other hand, the embodiment of the invention also provides a simulated ablation method of the tumor therapeutic apparatus, which comprises the following steps:
acquiring a tumor contour graph, and an ablatable region and an initial ablation region corresponding to the tumor contour graph;
when the initial ablation region is confirmed to fall into the ablatable region, judging whether the initial ablation region covers the tumor contour graph; the tumor contour graph is generated on a plane coordinate system by a graph generating module according to the obtained tumor size; the ablatable region is generated on a plane coordinate system by a graph generation module according to the size of the tumor and a preset safety interval; the initial ablation region is generated on a plane coordinate system by a region generation module based on the contour graph processing voltage; adding a simulation probe set in the tumor contour graph by the voltage area generation module, and applying the simulation probe set to obtain the voltage area;
if yes, confirming that the simulated ablation is finished;
if not, moving the simulation probe set and/or adjusting the voltage by a preset stepping value until the initial ablation area covers the tumor contour graph.
One of the above technical solutions has the following advantages and beneficial effects:
the graph generating module can acquire the tumor size input by a user and generate a tumor contour graph similar to the tumor shape on a plane coordinate system according to the tumor size; the graph generation module can also generate an ablatable region on the same plane coordinate system according to the preset safety interval and the tumor size, and the ablatable region which is larger than and can cover the tumor outline graph is obtained. The region generation module can generate an initial ablation region on a plane by applying voltage to the analog probe set added to the tumor contour graph and processing the voltage based on the contour graph, so that the initial ablation region corresponding to the electric field intensity distribution can be obtained. The region processing module judges whether the initial ablation region meets the ablation condition or not, and when the ablation condition is not met, the region processing module moves the simulation probe set and/or adjusts the voltage according to a preset stepping value until the initial ablation region meets the ablation condition; and when the ablation condition is met, confirming the completion of the simulation message, and realizing the simulation ablation of the tumor. According to the method, the accurate simulated ablation region can be obtained by processing the simulated probe set based on the tumor contour graph and the ablatable region, so that the accuracy of the simulation system for obtaining the ablation region is improved; and moreover, the ablation area does not need to be adjusted by professional personnel, so that the labor cost is reduced.
Detailed Description
To facilitate an understanding of the present application, the present application will now be described more fully with reference to the accompanying drawings. Preferred embodiments of the present application are shown in the drawings. This application may, however, be embodied in many different forms and should not be construed as limited to the embodiments set forth herein. Rather, these embodiments are provided so that this disclosure will be thorough and complete.
Unless defined otherwise, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this application belongs. The terminology used herein in the description of the present application is for the purpose of describing particular embodiments only and is not intended to be limiting of the application. As used herein, the term "and/or" includes any and all combinations of one or more of the associated listed items.
In one embodiment, as shown in fig. 1, a simulated ablation system for a tumor treatment apparatus is provided, which includes agraph generation module 110, aregion generation module 120, and aregion processing module 130 connected to thegraph generation module 110 and theregion generation module 120;
thegraph generating module 110 obtains the size of the tumor, generates a tumor contour graph on a plane coordinate system according to the size of the tumor, and generates an ablatable region corresponding to the tumor contour graph according to the size of the tumor and a preset safety interval;
theregion generation module 120 adds a simulation probe set to the tumor contour graph, applies a voltage to the simulation probe set, processes the voltage based on the contour graph, and generates an initial ablation region on a plane coordinate system;
when confirming that the initial ablation region falls into the ablatable region, theregion processing module 130 determines whether the initial ablation region covers the tumor contour graph; if yes, confirming that the simulated ablation is finished; if not, moving the simulation probe set and/or adjusting the voltage by a preset stepping value until the initial ablation area covers the tumor contour graph.
Thegraphic generation module 110 refers to a module or a device having functions of data processing, data transmission, and the like; thegraph generating module 110 can be used to draw a tumor contour graph on a plane coordinate system, so as to obtain a tumor contour graph corresponding to the size of the tumor; thegraph generation module 110 can also be used to plot the ablatable region on the planar coordinate system, so as to obtain the ablatable region corresponding to the tumor contour graph. Theregion generation module 120 refers to a module or a device having functions of data processing, data transmission, and the like; theregion generation module 120 can be used to map the initial ablation region on the plane coordinate system, so as to obtain the corresponding initial ablation region. Thearea processing module 130 refers to a module or a device having functions of data processing, data transmission, and the like; theregion processing module 130 can be used to adjust the initial ablation region according to the tumor contour pattern and the ablatable region, so that the initial ablation region satisfies the condition of covering the tumor contour pattern and falling into the ablatable region.
It should be noted that thegraphics generating module 110, theregion generating module 120, and theregion processing module 130 may be independent processors; thegraphics generation module 110, theregion generation module 120, and theregion processing module 130 may also be integrated processors that are integrated together, i.e., the integrated processors include thegraphics generation module 110, theregion generation module 120, and theregion processing module 130.
Specifically, the region-basedprocessing module 130 connects thegraphic generation module 110 and theregion generation module 120, respectively. Thegraph generating module 110 may be configured to obtain a tumor size input by a user, generate a tumor contour graph on a planar coordinate system according to the obtained tumor size, and transmit the generated tumor contour graph to theregion generating module 120 and theregion processing module 130, respectively. Thepattern generation module 120 may generate an ablatable region on the plane coordinate system according to a preset safety interval and a tumor size, so that the ablatable region can cover the tumor contour pattern, and transmit the generated ablatable region to theregion processing module 130. The shape of the ablatable region is consistent with that of the tumor outline graph, and the ablatable region is obtained by expanding a preset safety interval to the outside of the tumor outline graph; wherein, the outline of the tumor can be represented by the outline shape of the tumor. Theregion generating module 120 may further add a simulation probe set to the received tumor contour graph, and apply a voltage to the simulation probe set, so that an electric field intensity distribution is formed at an output end of the simulation probe set; the region generation module 10 may process the voltage based on the contour graph algorithm to generate an initial ablation region on the same planar coordinate system; and transmits the generated initial ablation region to theregion processing module 130.
Theregion processing module 130 may perform adjustment processing on the received initial ablation region, and determine whether the initial ablation region covers the tumor contour pattern when it is determined that the initial ablation region falls into the ablatable region; if yes, confirming that the simulated ablation is finished; if not, moving the simulation probe group or adjusting the voltage applied to the simulation probe group by a preset stepping value until the initial ablation area covers the tumor contour map. In one example, if not, the simulation probe set is moved and the voltage applied to the simulation probe set is adjusted by a preset step value until the initial ablation region covers the tumor contour graph, so as to realize the simulation ablation of the tumor.
Further, thegraph generating module 110 may draw a tumor contour on a preset plane coordinate system based on the tumor size, so as to obtain a tumor contour graph. Thegraph generating module 120 may further draw an ablatable region on the same plane coordinate system based on the preset safety interval and the tumor size, wherein the ablatable region may be a corresponding outline graph; theregion generation module 120 may plot an initial ablation region on the same planar coordinate system based on the voltage applied to the analog probe set, wherein the initial ablation region may be a corresponding outline pattern.
It should be noted that the planar coordinate system may be a planar rectangular coordinate system.
In the analog ablation system of the tumor therapeutic apparatus, a tumor contour graph similar to the shape of the tumor is generated through a graph generation module; generating an ablatable region through a graph generation module to obtain the ablatable region which is larger than and can cover the tumor outline graph; the region generation module can generate an initial ablation region, and then the initial ablation region corresponding to the electric field intensity distribution can be obtained. Judging whether the initial ablation region meets the ablation condition or not through a region processing module, and when the ablation condition is not met, moving the simulation probe set and/or adjusting the voltage according to a preset stepping value until the initial ablation region meets the ablation condition; when the ablation condition is met, confirming that the simulated ablation is completed, for example, outputting ablation parameter information corresponding to an initial ablation region to an ablation controller, so that the ablation controller performs simulated ablation processing on the tumor contour graph according to the ablation parameter information, the simulated ablation on the tumor is realized, an accurate simulated ablation region can be obtained through processing of a simulated probe set based on the tumor contour graph and the ablatable region, and the accuracy of the simulation system for obtaining the ablation region is improved; and moreover, the ablation area does not need to be adjusted by professional personnel, so that the labor cost is reduced.
In a specific embodiment, the graph generation module processes the tumor length and the tumor width based on the ellipse model to obtain a tumor contour graph; wherein the tumor size includes tumor length and tumor width.
Specifically, the graph generation module can determine the tumor length as an ellipse long axis and the tumor width as an ellipse short axis, and then can substitute the tumor length and the tumor width into the ellipse model for processing to obtain a tumor contour graph, so that the tumor contour graph can be quickly obtained, and the simulated ablation process is simplified.
In one example, after obtaining the tumor size input by the user, the graph generation module may parse the tumor size, and may obtain the tumor length and the tumor width.
It is noted that the tumor length may be the length of the front view (or back view) of the tumor; the tumor width may be the length of the front view (or back view) of the tumor. In one example, a map of the tumor may be acquired by an imaging device, and by measuring the map of the tumor, the tumor length and tumor width may be derived. Wherein the imaging device may be, but is not limited to, an ultrasound imaging device.
In a specific embodiment, the predetermined safety interval is in the range of 0.5 cm to 1 cm. For example, if the preset safety interval is 1 cm, the pattern generation module expands 1 cm outside the tumor outline pattern, so as to obtain an ablatable region.
In a specific embodiment, the ablatable region completely covers the tumor contour pattern.
Specifically, based on the fact that the size of the ablatable region is larger than that of the tumor outline pattern, the ablatable region and the tumor outline pattern are arranged on the same plane coordinate system, so that the ablatable region can safely cover the tumor outline pattern.
In one embodiment, the region generation module models the voltage to obtain a Laplace equation and solving conditions thereof, solves the Laplace equation to obtain a potential distribution model corresponding to the voltage, and processes the potential distribution model based on a field intensity potential relation to obtain an electric field intensity distribution model; and processing the electric field intensity distribution model based on a contour line drawing algorithm to obtain an initial ablation region.
Specifically, the region generation module can acquire a voltage applied to the analog probe set, and model the acquired voltage to obtain a corresponding laplace equation and a solving condition thereof; the region generation module can solve the Laplace equation based on the solving conditions to obtain a potential distribution model corresponding to the voltage, and process the potential distribution model based on the relation between the electric field intensity and the electric potential to obtain the electric field intensity distribution model. The region generation module can process the electric field intensity distribution model based on a contour drawing algorithm, and further can obtain a contour graph corresponding to electric field intensity distribution, wherein the contour graph is an initial ablation region.
It should be noted that the area generation module draws, based on the contour line drawing algorithm, an area that is greater than or equal to the area covered by the specific field strength value corresponding to the electric field strength distribution model, and only when the field strength is greater than or equal to the specific field strength value, the initial ablation area is determined to be valid.
In the analog ablation system of the tumor therapeutic apparatus, the voltage applied to the analog probe set is processed through the region generation module, so that an initial ablation region is obtained, the automation degree of analog ablation is improved, and the analog ablation process is simplified.
In one embodiment, the set of mock probes comprises at least one set of mock probe pairs; the analog probe pair includes at least one analog probe.
The simulation probe group comprises at least one simulation probe pair, and the simulation probe pair comprises at least one simulation probe. The analog probe can be used for outputting electric pulses; the analogue probe may be a bipolar probe or a unipolar probe.
Specifically, the region generation module may control the analog probe set to apply a voltage and may measure the voltage applied to the analog probe set, and may then process the measured voltage to obtain an initial ablation region. The area processing module can adjust the voltage applied to the simulation probe group based on the preset stepping value, and then can adjust the coverage of the initial ablation area, so that the initial ablation area covers the tumor outline graph and falls into the ablation area, and then automatic simulation ablation is realized, the process of simulation ablation is simplified, and the operation level requirement of a user is reduced.
It should be noted that the voltage may be provided to the analog probe set by a power module.
In one embodiment, the region generation module sequentially adds each analog probe pair to the tumor contour graph and applies a voltage to each analog probe pair; and sequentially processing the voltages of the corresponding simulated probe pairs based on the contour graph, and generating initial ablation sub-regions at corresponding positions of the corresponding simulated probe pairs.
Wherein the initial ablation sub-region is formed by applying a voltage with the analog probe pair.
Specifically, when the simulation probe set includes 2 or more sets of simulation probes, the region generation module may sequentially add each simulation probe pair to the tumor contour graph, and apply a voltage to each simulation probe pair; the output ends of the analog probe pairs form electric field intensity distribution; the region generation module can process the voltage of the corresponding simulation probe pair based on the contour graph algorithm, and further can generate an initial ablation sub-region corresponding to the corresponding position of the simulation probe pair.
In a specific embodiment, the region generation module may perform adjustment processing on each initial ablation sub-region, so that a combined region formed by each initial ablation sub-region satisfies a coverage tumor contour graph and falls into the ablatable region, and an adjusted initial ablation region can be obtained. And then the area generation module can combine the initial ablation sub-areas which meet the requirement of covering the tumor outline graph and fall into the ablation area to obtain the adjusted initial ablation area.
In one example, when the simulated probe set includes 1 set of simulated probes, the region generation module can add simulated probe pairs to the tumor contour graph and apply voltages to the simulated probe pairs; the output end of the analog probe pair forms electric field intensity distribution; the region generation module can process the voltage corresponding to the simulation probe pair based on the contour graph algorithm, further generate an initial ablation sub-region corresponding to the corresponding position of the simulation probe pair, and store the initial ablation sub-region; and then, moving the probe pair to form a new initial ablation sub-region, storing and moving again, and repeating the operation until a combined region formed by all the initial ablation sub-regions meets the requirement of covering a tumor contour graph and falls into an ablation region, thereby obtaining the initial ablation region after adjustment treatment.
In a specific embodiment, the area processing module moves the simulation probe set until the overlap area of the initial ablation area and the tumor outline graph is the largest, and the overlap area of the initial ablation area and the ablatable area is the largest; the voltage is increased or decreased by a preset step value until the initial ablation region overlays the tumor contour pattern and falls within the ablatable region.
Specifically, the area processing module can move the simulation probe set arranged on the tumor outline graph, so that the overlapping area of the initial ablation area and the tumor outline graph is the largest, and the overlapping area of the initial ablation area and the ablatable area is the largest; when the initial ablation region is confirmed to fall into the ablation region, whether the current initial ablation region completely covers the tumor contour graph or not is judged, if not, the voltage is increased or decreased by a preset step value until the initial ablation region covers the tumor contour graph, the tumor is simulated and ablated, the simulated ablation process is optimized, and the accuracy of the simulation system for acquiring the ablation region is improved; and moreover, the ablation area does not need to be adjusted by professional personnel, so that the labor cost is reduced.
In one embodiment, as shown in fig. 2, a simulated ablation system for a tumor treatment apparatus is provided, comprising agraph generating module 210, aregion generating module 220, and aregion processing module 230 connecting thegraph generating module 210 and theregion generating module 220; adisplay module 240 is also included that is coupled to theregion processing module 230. Thedisplay module 240 displays a tumor contour graphic, an ablatable region, and an initial ablation region.
Thedisplay module 240 may be a display, for example, thedisplay module 240 may be a liquid crystal display or an LED display.
Specifically, theregion processing module 230 is connected to thedisplay module 240, and theregion processing module 230 can transmit the processed tumor contour graph, the ablatable region and the initial ablation region to thedisplay module 240, so as to display the data related to the simulated ablation process through thedisplay module 240. The user can visually see the whole simulated ablation process through thedisplay module 240, the convenience of the system is improved, and the operation level requirement of the user is reduced.
In one embodiment, as shown in fig. 3, a method for simulating ablation of a tumor therapy device is provided, comprising the steps of:
step S310, acquiring a tumor contour graph, and an ablatable region and an initial ablation region corresponding to the tumor contour graph.
Step S320, when the initial ablation region is confirmed to fall into the ablation region, judging whether the initial ablation region covers the tumor contour graph; the tumor contour graph is generated on a plane coordinate system by a graph generating module according to the obtained tumor size; the ablatable region is generated on a plane coordinate system by a graph generation module according to the size of the tumor and a preset safety interval; the initial ablation region is generated on a plane coordinate system by a region generation module based on the contour graph processing voltage; and the voltage generation module adds a simulation probe set to the tumor contour graph and applies the simulation probe set.
Step S330, if yes, the completion of the simulated ablation is confirmed.
Step S340, if not, moving the simulation probe set and/or adjusting the voltage by a preset step value until the initial ablation region covers the tumor contour graph.
Specifically, the area processing module judges whether the initial ablation area meets the ablation condition, and when the ablation condition is not met, the area processing module moves the simulation probe set and/or adjusts the voltage according to a preset stepping value until the initial ablation area meets the ablation condition; when the ablation condition is met, confirming that the simulated ablation is completed, for example, outputting ablation parameter information corresponding to the initial ablation region to the ablation controller, so that the ablation controller carries out simulated ablation processing on the tumor contour graph according to the ablation parameter information, and the simulated ablation of the tumor is realized. The graph generating module can acquire the tumor size input by a user and generate a tumor contour graph similar to the tumor shape on a plane coordinate system according to the tumor size; the image generation module can also generate an ablatable region on the same plane coordinate system according to the preset safety interval and the size of the tumor wheel, so as to obtain the ablatable region which is larger than and can cover the tumor outline image; the region generation module can generate an initial ablation region on a plane by applying voltage to the analog probe set added to the tumor contour graph and processing the voltage based on the contour graph, so that the initial ablation region corresponding to the electric field intensity distribution can be obtained. Furthermore, an accurate simulated ablation region can be obtained by processing the simulated probe set based on the tumor contour graph and the ablatable region, so that the accuracy of the simulation system for obtaining the ablation region is improved; and moreover, the ablation area does not need to be adjusted by professional personnel, so that the labor cost is reduced.
It should be understood that, although the steps in the flowchart of fig. 3 are shown in order as indicated by the arrows, the steps are not necessarily performed in order as indicated by the arrows. The steps are not performed in the exact order shown and described, and may be performed in other orders, unless explicitly stated otherwise. Moreover, at least a portion of the steps in fig. 3 may include multiple sub-steps or multiple stages that are not necessarily performed at the same time, but may be performed at different times, and the order of performance of the sub-steps or stages is not necessarily sequential, but may be performed in turn or alternately with other steps or at least a portion of the sub-steps or stages of other steps.
It will be understood by those skilled in the art that all or part of the processes of the methods of the embodiments described above can be implemented by hardware instructions of a computer program, which can be stored in a non-volatile computer-readable storage medium, and when executed, can include the processes of the embodiments of the division methods described above. Any reference to memory, storage, database, or other medium used in the embodiments provided herein may include non-volatile and/or volatile memory, among others. Non-volatile memory can include read-only memory (ROM), Programmable ROM (PROM), Electrically Programmable ROM (EPROM), Electrically Erasable Programmable ROM (EEPROM), or flash memory. Volatile memory can include Random Access Memory (RAM) or external cache memory. By way of illustration and not limitation, RAM is available in a variety of forms such as Static RAM (SRAM), Dynamic RAM (DRAM), Synchronous DRAM (SDRAM), Double Data Rate SDRAM (DDRSDRAM), Enhanced SDRAM (ESDRAM), Synchronous Link DRAM (SLDRAM), Rambus Direct RAM (RDRAM), direct bus dynamic RAM (DRDRAM), and memory bus dynamic RAM (RDRAM).
The technical features of the embodiments described above may be arbitrarily combined, and for the sake of brevity, all possible combinations of the technical features in the embodiments described above are not described, but should be considered as being within the scope of the present specification as long as there is no contradiction between the combinations of the technical features.
The above-mentioned embodiments only express several embodiments of the present application, and the description thereof is more specific and detailed, but not construed as limiting the scope of the invention. It should be noted that, for a person skilled in the art, several variations and modifications can be made without departing from the concept of the present application, which falls within the scope of protection of the present application. Therefore, the protection scope of the present patent shall be subject to the appended claims.