CN111317856B - A kind of preparation method of medical durable sterilization breathable isolation film - Google Patents

Abstract

The invention discloses a preparation method of a medical durable bactericidal breathable isolating membrane, which is characterized in that aluminum oxide adsorbed with copper sulfate is coated on the surface of a base membrane, and single-layer coating is adopted, so that the isolating membrane has the advantages of water repellency of the base membrane surface, hydrophilic one-way water permeability of the coated surface, and wound healing efficiency improvement.

Description

Translated fromChinese

一种医用持久杀菌透气隔离膜的制备方法A kind of preparation method of medical durable sterilization breathable isolation film

技术领域technical field

本发明属于负载型功能薄膜材料技术领域，具体涉及一种医用持久杀菌透气隔离膜的制备方法。The invention belongs to the technical field of load-type functional film materials, in particular to a preparation method of a medical durable sterilization breathable isolation film.

背景技术Background technique

传统的病人伤口处理时大部分都是采用擦拭消毒液进行消毒，而伤口包扎后，杀菌效果难以持久，同时包扎材料透气性差，易导致病人伤口处闷热，增加了细菌感染的风险。Most of the traditional wounds of patients are disinfected with wiping disinfectant. After the wound is bandaged, the sterilization effect is difficult to last. At the same time, the air permeability of the bandage material is poor, which can easily cause the patient's wound to be sultry and increase the risk of bacterial infection.

专利CN110016222A公开了一种杀菌透气薄膜的制备方法，使含氮化碳、高分子聚合物和有机溶剂的前驱体溶液形成薄膜后，进行预干燥，预干燥结束后于110～130℃干燥，然后除去有机溶剂形成透气孔。该专利所制备的薄膜具有透气杀菌作用，但该透气薄膜具有两面均亲水或疏水性，当透气薄膜为亲水性时，包扎材料接触水后，吸收水分，导致病人伤口遇水，影响伤口愈合；当透气薄膜为疏水性时，包扎的伤口处在长时间的密封后，产生的水分不容易排除，造成伤口再次感染，影响伤口愈合。Patent CN110016222A discloses a preparation method of a sterilization and breathable film. After the precursor solution containing carbon nitride, high molecular polymer and organic solvent is formed into a film, it is pre-dried. The organic solvent is removed to form vents. The film prepared by this patent has the effect of breathability and sterilization, but the breathable film has hydrophilic or hydrophobicity on both sides. When the breathable film is hydrophilic, after the wrapping material contacts water, it absorbs water, causing the patient's wound to encounter water and affecting the wound. Healing; when the breathable film is hydrophobic, the water that is produced is not easy to be removed after the wound is sealed for a long time, causing the wound to be re-infected and affecting the healing of the wound.

发明内容SUMMARY OF THE INVENTION

本发明的目的之一是针对现有技术存在的问题，提供一种医用持久杀菌透气隔离膜的制备方法，使制备的隔离膜不仅具有良好的透气性能，同时具备持久杀菌效果，还具备基膜面斥水，涂覆面亲水的单向透水能力。One of the objectives of the present invention is to provide a preparation method of a medical durable sterilization breathable isolation film in view of the problems existing in the prior art, so that the prepared isolation film not only has good air permeability, but also has a durable bactericidal effect and a base film. The surface is water repellent, and the coated surface is hydrophilic with one-way water permeability.

为实现上述目的，本发明采用的技术方案是：For achieving the above object, the technical scheme adopted in the present invention is:

一种医用持久杀菌透气隔离膜的制备方法，其特征在于，具体包括如下步骤：A preparation method of a medical durable sterilization breathable isolation film, characterized in that it specifically comprises the following steps:

S1：将纳米多孔氧化铝与0.58-4.64mol/L的硫酸铜溶液搅拌均匀，再在100-200℃下烘干，制成吸附有硫酸铜的纳米多孔氧化铝；S1: stirring the nanoporous alumina and 0.58-4.64mol/L copper sulfate solution evenly, and then drying at 100-200°C to prepare nanoporous alumina adsorbed with copper sulfate;

S2：将吸附有硫酸铜的纳米多孔氧化铝与分散剂、润湿剂、粘结剂、增稠剂、交联剂、纯水混合均匀，制备含有硫酸铜的氧化铝浆料；S2: Mix the nanoporous alumina adsorbed with copper sulfate with dispersant, wetting agent, binder, thickener, crosslinking agent and pure water uniformly to prepare alumina slurry containing copper sulfate;

S3：将含有硫酸铜的氧化铝浆料涂覆到高分子多孔薄膜上方，涂覆后在100-200℃下烘烤，冷却得到隔离膜。S3: Coating the alumina slurry containing copper sulfate on the polymer porous film, baking at 100-200° C. after coating, and cooling to obtain the isolation film.

上述方法在制备过程中，以高分子多孔薄膜为基膜，通过含有硫酸铜的氧化铝浆料与分散剂、润湿剂、粘结剂、增稠剂、交联剂的均匀混合后，将吸附有硫酸铜的氧化铝颗粒涂覆到基膜表面，使隔离膜具备基膜面斥水，涂覆面亲水的单向透水能力，将涂覆面贴向伤口，提高伤口的愈合效率，该隔离膜不仅具有良好的透气性能，同时具备重金属离子的持久杀菌效果。In the preparation process of the above method, the porous polymer film is used as the base film, and the alumina slurry containing copper sulfate is uniformly mixed with dispersant, wetting agent, binder, thickener and crosslinking agent, and then the The aluminum oxide particles adsorbed with copper sulfate are coated on the surface of the base film, so that the isolation film has the ability of water repellency on the base film surface and hydrophilic one-way water permeability on the coated surface. The coated surface is attached to the wound to improve the healing efficiency of the wound. The membrane not only has good air permeability, but also has the lasting sterilization effect of heavy metal ions.

进一步地，所述纳米多孔氧化铝与硫酸铜溶液的重量百分比为1：0.1-10。当硫酸铜溶液的含量越多时，隔离膜的抗菌效率越高；当所述硫酸铜溶液的浓度范围低于本申请的浓度范围时，由于硫酸铜溶液的含量过低，使隔离膜对菌的去除率低，使抗菌效率很大程度上降低。当所述硫酸铜溶液的浓度范围高于本申请的浓度范围时，继续增加硫酸铜溶液的含量时，隔离膜对菌的抗菌性达到饱和，使抗菌效率无变化，但硫酸铜溶液过高，纳米多孔氧化铝的表面被硫酸铜全部包覆，使隔离膜的亲水性变弱，降低了隔离膜的吸水性。Further, the weight percentage of the nanoporous alumina and the copper sulfate solution is 1:0.1-10. When the content of the copper sulfate solution is more, the antibacterial efficiency of the isolation film is higher; when the concentration range of the copper sulfate solution is lower than the concentration range of the present application, because the content of the copper sulfate solution is too low, the isolation film is less effective against bacteria. The removal rate is low, which greatly reduces the antibacterial efficiency. When the concentration range of the copper sulfate solution is higher than the concentration range of the application, when the content of the copper sulfate solution is continued to increase, the antibacterial property of the isolation film to bacteria reaches saturation, so that the antibacterial efficiency does not change, but the copper sulfate solution is too high, The surface of the nanoporous alumina is completely covered by copper sulfate, which weakens the hydrophilicity of the separator and reduces the water absorption of the separator.

进一步地，所述纳米多孔氧化铝与硫酸铜溶液的重量百分比为1：5。Further, the weight percentage of the nanoporous alumina and the copper sulfate solution is 1:5.

进一步地，所述硫酸铜的氧化铝浆料、分散剂、粘结剂、增稠剂、润湿剂、水的质量百分比为1：0.003-0.017：0.025-0.093：0.003-0.035：0.002-0.0096：1.1-5.5。优选地，所述所述硫酸铜的氧化铝浆料、分散剂、粘结剂、增稠剂、润湿剂、水的质量百分比为1：0.001：0.064：0.015：0.0055：2.5。Further, the mass percentage of the copper sulfate alumina slurry, dispersant, binder, thickener, wetting agent and water is 1:0.003-0.017:0.025-0.093:0.003-0.035:0.002-0.0096 : 1.1-5.5. Preferably, the mass percentages of the copper sulfate alumina slurry, dispersant, binder, thickener, wetting agent and water are 1:0.001:0.064:0.015:0.0055:2.5.

进一步地，步骤S2中先将含有硫酸铜的纳米多孔氧化铝与分散剂、增稠剂搅拌砂磨，形成混合液A，使混合液中固体颗粒的粒径为0.1μm-15μm，再将混合液A与粘结剂和润湿剂混合均匀。Further, in step S2, the nanoporous alumina containing copper sulfate, the dispersing agent and the thickening agent are first stirred and sanded to form a mixed solution A, so that the particle size of the solid particles in the mixed solution is 0.1 μm-15 μm, and then mixed. Liquid A is mixed well with the binder and wetting agent.

进一步地，所述高分子多孔薄膜为聚丙烯薄膜、聚乙烯薄膜和聚对苯二甲酸乙二醇酯薄膜中的一种，所述高分子多孔薄膜的厚度为1μm-500μm；所述高分子多孔薄膜的孔直径为10-500nm。Further, the polymer porous film is one of polypropylene film, polyethylene film and polyethylene terephthalate film, and the thickness of the polymer porous film is 1 μm-500 μm; The pore diameter of the porous film is 10-500 nm.

进一步地，所述纳米多孔氧化铝的孔直径为50-500nm。Further, the pore diameter of the nanoporous alumina is 50-500 nm.

进一步地，所述分散剂为水玻璃、三聚磷酸钠、六偏磷酸钠、焦磷酸钠、三乙基己基磷酸、十二烷基硫酸钠、甲基戊醇、纤维素衍生物、聚丙烯酰胺、古尔胶、脂肪酸聚乙二醇酯中的至少一种。Further, the dispersing agent is water glass, sodium tripolyphosphate, sodium hexametaphosphate, sodium pyrophosphate, triethylhexylphosphoric acid, sodium lauryl sulfate, methyl amyl alcohol, cellulose derivatives, polypropylene At least one of amide, gum gum, fatty acid polyethylene glycol ester.

进一步地，所述润湿剂为聚硅氧烷季铵盐-16、聚硅氧烷季铵盐-18中的一种；所述的粘结剂为丙烯酸、甲基丙烯酸，聚醋酸乙烯苯二甲酸酯、甲基丙烯酸甲酯中一种；所述的增稠剂为羧甲基丙烯酸钠。Further, the wetting agent is one of polysiloxane quaternary ammonium salt-16 and polysiloxane quaternary ammonium salt-18; the binder is acrylic acid, methacrylic acid, polyvinyl acetate benzene One of diformate and methyl methacrylate; the thickener is sodium carboxymethacrylate.

与现有技术相比，本发明的有益效果是：Compared with the prior art, the beneficial effects of the present invention are:

(1)本发明将吸附有硫酸铜的氧化铝涂覆到基膜表面，采用单层涂覆，使隔离膜具备基膜面斥水，涂覆面亲水的单向透水能力，提高伤口的愈合效率，该隔离膜不仅具有良好的透气性能，同时具备重金属离子的持久抗菌杀菌效果。(1) In the present invention, aluminum oxide adsorbed with copper sulfate is applied to the surface of the base film, and single-layer coating is adopted, so that the isolation film has the water repellency of the base film surface and the unidirectional water permeability of the hydrophilic coating surface to improve the healing of wounds. The separator not only has good air permeability, but also has the durable antibacterial and bactericidal effect of heavy metal ions.

(2)本发明通过控制纳米多孔氧化铝与硫酸铜溶液的重量百分比，使隔离膜具有优异的抗菌效率。(2) In the present invention, by controlling the weight percentage of nanoporous alumina and copper sulfate solution, the separator has excellent antibacterial efficiency.

附图说明Description of drawings

图1为实施例1中所述隔离膜的结构示意图。FIG. 1 is a schematic structural diagram of the isolation film described in Example 1. FIG.

具体实施方式Detailed ways

下面将结合本发明中的附图，对本发明的技术方案进行清楚、完整地描述，显然，所描述的实施例仅仅是本发明一部分实施例，而不是全部的实施例。基于本发明中的实施例，本领域普通技术人员在没有做出创造性劳动条件下所获得的所有其它实施例，都属于本发明保护的范围。The technical solutions of the present invention will be clearly and completely described below with reference to the accompanying drawings of the present invention. Obviously, the described embodiments are only a part of the embodiments of the present invention, not all of the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by persons of ordinary skill in the art without creative efforts shall fall within the protection scope of the present invention.

上述一种医用持久杀菌透气隔离膜的制备方法中，所述高分子多孔薄膜的厚度，高分子多孔薄膜的孔直径，所述纳米多孔氧化铝的孔直径，所述高分子多孔薄膜、分散剂、粘结剂、增稠剂、润湿剂的种类对伤口治愈率性能影响不大。In the above-mentioned preparation method of a medical durable sterilization and breathable isolation film, the thickness of the polymer porous film, the pore diameter of the polymer porous film, the pore diameter of the nanoporous alumina, the polymer porous film, the dispersant , Binder, thickener and wetting agent have little effect on wound healing rate performance.

实施例1Example 1

一种医用持久杀菌透气隔离膜的制备方法，具体包括如下步骤：A preparation method of a medical durable sterilization breathable isolation film specifically comprises the following steps:

S1：将1.5kg孔直径为200nm的纳米多孔氧化铝倒入7.5kg的2.5mol/L硫酸铜溶液中进行搅拌均匀，制成吸附有硫酸铜的纳米多孔氧化铝；S1: Pour 1.5kg of nanoporous alumina with a pore diameter of 200nm into 7.5kg of a 2.5mol/L copper sulfate solution and stir evenly to prepare nanoporous alumina adsorbed with copper sulfate;

S2：取1kg吸附有硫酸铜的纳米多孔氧化铝与1g分散剂、15g增稠剂羧甲基丙烯酸钠溶液、64g粘结剂丙烯酸和5.5g润湿剂聚硅氧烷季铵盐-16搅拌，加入2.5kg水混合均匀；制备含有硫酸铜的氧化铝浆料；S2: Take 1kg of nanoporous alumina adsorbed with copper sulfate and stir with 1g of dispersant, 15g of thickener sodium carboxymethacrylate solution, 64g of binder acrylic acid and 5.5g of wetting agent polysiloxane quaternary ammonium salt-16 , add 2.5kg of water and mix evenly; prepare alumina slurry containing copper sulfate;

S3：将步骤S2中含有硫酸铜的氧化铝浆料涂覆到厚度为22μm、孔直径为40nm的聚丙烯薄膜上方，涂覆后在150℃下烘烤，冷却得到隔离膜。S3: Coating the alumina slurry containing copper sulfate in step S2 on the polypropylene film with a thickness of 22 μm and a pore diameter of 40 nm, baking at 150° C. after coating, and cooling to obtain a separator.

实施例2Example 2

实施例2与实施例1的区别在于：The difference between embodiment 2 and embodiment 1 is:

S1：将1.5kg孔直径为200nm的纳米多孔氧化铝倒入0.15kg的2.5mol/L硫酸铜溶液中进行搅拌均匀，制成吸附有硫酸铜的纳米多孔氧化铝。S1: Pour 1.5 kg of nanoporous alumina with a pore diameter of 200 nm into 0.15 kg of a 2.5 mol/L copper sulfate solution, and stir evenly to prepare nanoporous alumina adsorbed with copper sulfate.

实施例3Example 3

实施例3与实施例1的区别在于：The difference between Example 3 and Example 1 is:

S1：将1.5kg孔直径为200nm的纳米多孔氧化铝倒入4.5kg的2.5mol/L硫酸铜溶液中进行搅拌均匀，制成吸附有硫酸铜的纳米多孔氧化铝。S1: Pour 1.5 kg of nanoporous alumina with a pore diameter of 200 nm into 4.5 kg of 2.5 mol/L copper sulfate solution and stir evenly to prepare nanoporous alumina adsorbed with copper sulfate.

实施例4Example 4

实施例4与实施例1的区别在于：The difference between Example 4 and Example 1 is:

S1：将1.5kg孔直径为200nm的纳米多孔氧化铝倒入15kg的2.5mol/L硫酸铜溶液中进行搅拌均匀，制成吸附有硫酸铜的纳米多孔氧化铝。S1: Pour 1.5 kg of nanoporous alumina with a pore diameter of 200 nm into 15 kg of 2.5 mol/L copper sulfate solution and stir evenly to prepare nanoporous alumina adsorbed with copper sulfate.

实施例5Example 5

实施例5与实施例1的区别在于：The difference between embodiment 5 and embodiment 1 is:

S2：取1kg吸附有硫酸铜的纳米多孔氧化铝与17g分散剂、35g增稠剂羧甲基丙烯酸钠溶液、93g粘结剂丙烯酸和9.6g润湿剂聚硅氧烷季铵盐-16，加入5.5kg水混合均匀；制备含有硫酸铜的氧化铝浆料。S2: Take 1kg of nanoporous alumina adsorbed with copper sulfate, 17g of dispersant, 35g of thickener sodium carboxymethacrylate solution, 93g of binder acrylic acid and 9.6g of wetting agent polysiloxane quaternary ammonium salt-16, Add 5.5kg of water and mix evenly; prepare alumina slurry containing copper sulfate.

实施例6Example 6

实施例6与实施例1的区别在于：The difference between embodiment 6 and embodiment 1 is:

S2：取1kg吸附有硫酸铜的纳米多孔氧化铝与3g分散剂、3g增稠剂羧甲基丙烯酸钠溶液、25g粘结剂丙烯酸和2g润湿剂聚硅氧烷季铵盐-16，加入1.1kg水混合均匀；制备含有硫酸铜的氧化铝浆料。S2: Take 1kg of nanoporous alumina adsorbed with copper sulfate, 3g of dispersant, 3g of thickener sodium carboxymethacrylate solution, 25g of binder acrylic acid and 2g of wetting agent polysiloxane quaternary ammonium salt-16, add 1.1 kg of water was mixed evenly; an alumina slurry containing copper sulfate was prepared.

实施例7Example 7

实施例7与实施例1的区别在于：The difference between embodiment 7 and embodiment 1 is:

S2：取1kg吸附有硫酸铜的纳米多孔氧化铝与1g分散剂、15g增稠剂羧甲基丙烯酸钠溶液混合均匀，搅拌砂磨，形成混合液A，使混合液中固体颗粒的粒径为5μm，再将混合液A与64g粘结剂丙烯酸、5.5g润湿剂聚硅氧烷季铵盐-16和2.5kg水混合均匀；制备含有硫酸铜的氧化铝浆料。S2: get 1kg of nanoporous alumina adsorbed with copper sulfate and mix it with 1g of dispersant and 15g of thickener sodium carboxymethacrylate solution, stirring and sanding to form mixed solution A, so that the particle size of the solid particles in the mixed solution is 5 μm, and then mix the mixed solution A with 64 g of binder acrylic acid, 5.5 g of wetting agent polysiloxane quaternary ammonium salt-16 and 2.5 kg of water; prepare alumina slurry containing copper sulfate.

对比例1Comparative Example 1

对比例1与实施例1的区别在于：The difference between Comparative Example 1 and Example 1 is:

S1：将1.5kg孔直径为200nm的纳米多孔氧化铝倒入0.12kg的2.5mol/L硫酸铜溶液中进行搅拌均匀，制成吸附有硫酸铜的纳米多孔氧化铝。S1: Pour 1.5 kg of nanoporous alumina with a pore diameter of 200 nm into 0.12 kg of a 2.5 mol/L copper sulfate solution and stir evenly to prepare nanoporous alumina adsorbed with copper sulfate.

对比例2Comparative Example 2

对比例2与实施例1的区别在于：The difference between Comparative Example 2 and Example 1 is:

S1：将1.5kg孔直径为200nm的纳米多孔氧化铝倒入18kg的2.5mol/L硫酸铜溶液中进行搅拌均匀，制成吸附有硫酸铜的纳米多孔氧化铝。S1: Pour 1.5 kg of nanoporous alumina with a pore diameter of 200 nm into 18 kg of 2.5 mol/L copper sulfate solution and stir evenly to prepare nanoporous alumina adsorbed with copper sulfate.

对比例3Comparative Example 3

对比例3与实施例1的区别在于：The difference between Comparative Example 3 and Example 1 is:

S2：取1.2kg吸附有硫酸铜的纳米多孔氧化铝与20g分散剂、40g增稠剂羧甲基丙烯酸钠溶液、100g粘结剂丙烯酸和12g润湿剂聚硅氧烷季铵盐-16，加入6kg水混合均匀；制备含有硫酸铜的氧化铝浆料。S2: Take 1.2kg of nanoporous alumina adsorbed with copper sulfate, 20g of dispersant, 40g of thickener sodium carboxymethacrylate solution, 100g of binder acrylic acid and 12g of wetting agent polysiloxane quaternary ammonium salt-16, Add 6kg of water and mix evenly; prepare alumina slurry containing copper sulfate.

对比例4Comparative Example 4

对比例4与实施例1的区别在于：The difference between Comparative Example 4 and Example 1 is:

S2：取0.8kg吸附有硫酸铜的纳米多孔氧化铝与1g分散剂、1g增稠剂羧甲基丙烯酸钠溶液、15g粘结剂丙烯酸和1g润湿剂聚硅氧烷季铵盐-16，加入1kg水混合均匀；制备含有硫酸铜的氧化铝浆料。S2: Take 0.8kg of nanoporous alumina adsorbed with copper sulfate, 1g of dispersant, 1g of thickener sodium carboxymethacrylate solution, 15g of binder acrylic acid and 1g of wetting agent polysiloxane quaternary ammonium salt-16, Add 1kg of water and mix evenly; prepare alumina slurry containing copper sulfate.

对比例5Comparative Example 5

S1：取1kg纳米多孔氧化铝与1g分散剂、15g增稠剂羧甲基丙烯酸钠溶液、64g粘结剂丙烯酸和5.5g润湿剂聚硅氧烷季铵盐-16搅拌，加入2.5kg水混合均匀；制备氧化铝浆料；S1: Take 1kg of nanoporous alumina, stir with 1g dispersant, 15g thickener sodium carboxymethacrylate solution, 64g binder acrylic acid and 5.5g wetting agent polysiloxane quaternary ammonium salt-16, add 2.5kg water Mix evenly; prepare alumina slurry;

S2：将步骤S1中氧化铝浆料涂覆到厚度为22μm、孔直径为40nm的聚丙烯薄膜上方，涂覆后在150℃下烘烤，冷却得到隔离膜。S2: Coating the alumina slurry in step S1 on the polypropylene film with a thickness of 22 μm and a pore diameter of 40 nm, baking at 150° C. after coating, and cooling to obtain an isolation film.

对比例6Comparative Example 6

S1：取0.17kg纳米多孔氧化铝、0.83kg2.5mol/L硫酸铜溶液、1g分散剂、15g增稠剂羧甲基丙烯酸钠溶液、64g粘结剂丙烯酸和5.5g润湿剂聚硅氧烷季铵盐-16搅拌，加入2.5kg水混合均匀；制备混合溶液A；S1: Take 0.17kg of nanoporous alumina, 0.83kg of 2.5mol/L copper sulfate solution, 1g of dispersant, 15g of thickener sodium carboxymethacrylate solution, 64g of binder acrylic acid and 5.5g of wetting agent polysiloxane Quaternary ammonium salt-16 was stirred, and 2.5 kg of water was added to mix evenly; mixed solution A was prepared;

S2：将步骤S2中混合溶液A涂覆到厚度为22μm、孔直径为40nm的聚丙烯薄膜上方，涂覆后在150℃下烘烤，冷却得到隔离膜。S2: Coating the mixed solution A in step S2 on the polypropylene film with a thickness of 22 μm and a pore diameter of 40 nm, baking at 150° C. after coating, and cooling to obtain an isolation film.

应用例Application example

实施例1-6制备的隔离膜的结构示意图具有同样的结构，这里将选取实施例1中隔离膜的结构示意图，其结构如图1所示。The schematic structural diagrams of the isolation films prepared in Examples 1-6 have the same structure. Here, the schematic structural diagrams of the isolation films in Example 1 will be selected, and the structure is shown in FIG. 1 .

将实施例1-6和对比例1-4制备的隔离膜用于大肠杆菌的抗菌性测试，采用AATCC-l00方法用于抗菌效率的评价，抗菌效率如下表1所示。The isolation films prepared in Examples 1-6 and Comparative Examples 1-4 were used for the antibacterial test of Escherichia coli, and the AATCC-100 method was used for the evaluation of the antibacterial efficiency. The antibacterial efficiency is shown in Table 1 below.

将实施例1-6和对比例1-4制备的隔离膜用于接触角测试，接触角如下表1所示。The separators prepared in Examples 1-6 and Comparative Examples 1-4 were used for the contact angle test, and the contact angles are shown in Table 1 below.

表1抗菌效率Table 1 Antibacterial efficiency

综上所述，通过比较实施例1-4和对比例1-2可知，当硫酸铜溶液的含量越多时，隔离膜的抗菌效率越高，当硫酸铜的含量继续增加时，由于纳米多孔氧化铝的表面被硫酸铜包覆，由于纳米多孔氧化铝能够改善基膜的表面结构，增加隔离膜的表面粗糙度，当纳米多孔氧化铝减少时，隔离膜亲水性能力降低。根据对比例1可知，当所述硫酸铜溶液的浓度范围低于本申请的浓度范围时，由于硫酸铜溶液的含量过低，使隔离膜对大肠杆菌的去除率低，使抗菌效率很大程度上降低。根据对比例2可知，当所述硫酸铜溶液的浓度范围高于本申请的浓度范围时，继续增加硫酸铜溶液的含量时，隔离膜对大肠杆菌的抗菌性达到饱和，使抗菌效率无变化，但硫酸铜溶液过高，纳米多孔氧化铝的表面被硫酸铜全部包覆，使隔离膜的亲水性变弱，降低了隔离膜的吸水性。因此，所述纳米多孔氧化铝与硫酸铜溶液优选为1：0.1-10。To sum up, by comparing Examples 1-4 and Comparative Examples 1-2, it can be seen that when the content of copper sulfate solution is more, the antibacterial efficiency of the separator is higher, and when the content of copper sulfate continues to increase, due to the nanoporous oxidation The surface of aluminum is coated with copper sulfate. Since the nanoporous alumina can improve the surface structure of the base film and increase the surface roughness of the separator, when the nanoporous alumina decreases, the hydrophilicity of the separator decreases. According to Comparative Example 1, when the concentration range of the copper sulfate solution is lower than the concentration range of the present application, because the content of the copper sulfate solution is too low, the removal rate of Escherichia coli by the isolation membrane is low, and the antibacterial efficiency is largely up and down. According to Comparative Example 2, when the concentration range of the copper sulfate solution is higher than the concentration range of the present application, when the content of the copper sulfate solution is continued to increase, the antibacterial property of the isolation film to Escherichia coli reaches saturation, so that the antibacterial efficiency does not change, However, the copper sulfate solution is too high, and the surface of the nanoporous alumina is completely covered by copper sulfate, which weakens the hydrophilicity of the separator and reduces the water absorption of the separator. Therefore, the nanoporous alumina and copper sulfate solution is preferably 1:0.1-10.

通过比较实施例1、4、5和对比例3-4可知，采用本申请范围内的各组分配比时，制备的隔离膜具有优异的抗菌效率。当各组分配比用量较少时，含有硫酸铜的氧化铝浆料分散不均，影响了隔离膜的抗菌效果；各组分配比用量较多时，制备的隔离膜的抗菌效率无明显变化，因此，为了节约生成制造成本，优选所述硫酸铜的氧化铝浆料：分散剂：粘结剂：增稠剂：润湿剂的质量百分比为1：0.003-0.017：0.025-0.093：0.003-0.035：0.002-0.0096。By comparing Examples 1, 4, 5 and Comparative Examples 3-4, it can be seen that when the distribution ratio of each component within the scope of the present application is used, the prepared separator has excellent antibacterial efficiency. When the dosage of each group is relatively small, the alumina slurry containing copper sulfate is unevenly dispersed, which affects the antibacterial effect of the separator; when the dosage of each group is relatively large, the antibacterial efficiency of the prepared separator does not change significantly. , in order to save the production cost, preferably the mass percentage of the copper sulfate alumina slurry: dispersant: binder: thickener: wetting agent is 1: 0.003-0.017: 0.025-0.093: 0.003-0.035: 0.002-0.0096.

采用实施例6中的制备方法时，由于预先制定均一的颗粒，再制备含有硫酸铜的氧化铝浆料，使硫酸铜的氧化铝浆料在聚丙烯薄膜上方的孔隙率均一，提高了隔离膜的透气性和抗菌效率。When the preparation method in Example 6 is adopted, since the uniform particles are pre-prepared, the alumina slurry containing copper sulfate is prepared, so that the porosity of the alumina slurry of copper sulfate above the polypropylene film is uniform, and the isolation film is improved. breathability and antibacterial efficiency.

分析对比例5的数据可知，由于不含有硫酸铜，不能起到杀菌作用，隔离膜具有很差的抗菌效率。Analysis of the data of Comparative Example 5 shows that since it does not contain copper sulfate, it cannot play a bactericidal effect, and the isolation film has poor antibacterial efficiency.

分析对比例6的数据可知，由于硫酸铜在混合溶液A中分散不均匀，使隔离膜的抗菌效率降低。Analysis of the data of Comparative Example 6 shows that the antibacterial efficiency of the separator is reduced due to the uneven dispersion of copper sulfate in the mixed solution A.

尽管已经示出和描述了本发明的实施例，对于本领域的普通技术人员而言，可以理解在不脱离本发明的原理和精神的情况下可以对这些实施例进行多种变化、修改、替换和变型，本发明的范围由所附权利要求及其等同物限定。Although embodiments of the present invention have been shown and described, it will be understood by those skilled in the art that various changes, modifications, and substitutions can be made in these embodiments without departing from the principle and spirit of the invention and modifications, the scope of the present invention is defined by the appended claims and their equivalents.

Claims (7)

1. A preparation method of a medical durable bactericidal breathable isolating membrane is characterized by comprising the following steps:

s1: uniformly stirring the nano porous alumina and 0.58-4.64mol/L copper sulfate solution, and drying at 100-200 ℃ to prepare the nano porous alumina adsorbed with copper sulfate;

s2: uniformly mixing the nano porous alumina adsorbed with copper sulfate, a dispersing agent, a wetting agent, a binder, a thickening agent, a cross-linking agent and pure water to prepare alumina slurry containing copper sulfate;

s3: and (4) coating the alumina slurry containing copper sulfate in the step S2 on the polymer porous film, baking at 100-200 ℃ after coating, and cooling to obtain the isolating film.

2. The method for preparing a medical durable sterilization breathable isolating membrane as claimed in claim 1, wherein the weight percentage of the nano porous alumina to the copper sulfate solution is 1: 0.1-10.

3. The method for preparing a medical durable sterilization breathable isolating membrane as claimed in claim 2, wherein the weight percentage of the nano porous alumina to the copper sulfate solution is 1: 5.

4. The method of claim 1, wherein in step S2, the nano porous alumina containing copper sulfate, the dispersant and the thickener are first mixed and sand-milled to form a mixture a, the particle size of the solid particles in the mixture is 0.1 μm to 15 μm, and then the mixture a is mixed with the binder and the wetting agent uniformly.

5. The method for preparing a medical durable sterilization breathable isolating membrane according to claim 1, wherein the polymer porous membrane is one of a polypropylene membrane, a polyethylene membrane and a polyethylene terephthalate membrane, and the thickness of the polymer porous membrane is 1 μm to 500 μm; the diameter of the hole of the polymer porous film is 10-500 nm.

6. A method for preparing a medical durable bactericidal breathable barrier film according to claim 1, wherein the pore diameter of the nanoporous alumina is 50-500 nm.

7. The method for preparing a medical durable bactericidal breathable isolating membrane according to claim 1, wherein the dispersing agent is at least one of water glass, sodium tripolyphosphate, sodium hexametaphosphate, sodium pyrophosphate, triethylhexylphosphoric acid, sodium dodecyl sulfate, methylpentanol, cellulose derivatives, polyacrylamide, guar gum and fatty acid polyglycol ester; the wetting agent is one of polysiloxane quaternary ammonium salt-16 and polysiloxane quaternary ammonium salt-18; the binder is one of acrylic acid, methacrylic acid, polyvinyl acetate phthalate and methyl methacrylate; the thickening agent is sodium carboxymethyl acrylate.

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