技术领域technical field
本发明涉及医药保健技术领域，具体而言，涉及一种紫杉醇药包及其制备方法和用途。The invention relates to the technical field of medicine and health care, in particular, to a paclitaxel medicine package and a preparation method and application thereof.
背景技术Background technique
红豆杉，别称扁柏、红豆树、紫衫，味微甘，性平，全身都可以入药，分布于北半球，是世界上公认濒临灭绝的天然珍稀抗癌植物，是第四纪冰川遗留下来的古老树种，在地球上已有250万年的历史。由于在自然条件下红豆杉生长速度缓慢，再生能力差，所以很长时间以来，世界范围内还没有形成大规模红豆杉原料林基地。Taxus, also known as cypress, red bean, and yew, has a slightly sweet taste and a flat nature. It can be used as medicine all over the body. It is distributed in the northern hemisphere. It is a natural and rare anti-cancer plant recognized as endangered in the world. Tree species have a history of 2.5 million years on the earth. Due to the slow growth rate and poor regeneration ability of Taxus chinensis under natural conditions, a large-scale forest base of Taxus chinensis has not been formed in the world for a long time.
红豆杉的果实和枝叶中富含紫杉醇、蛋白质和钙、磷、铁等矿物质及多种维生素，是天然的抗氧化、抗衰老的植物。The fruits, branches and leaves of Taxus chinensis are rich in paclitaxel, protein, minerals such as calcium, phosphorus, iron and various vitamins, which are natural antioxidant and anti-aging plants.
紫杉醇是一种从裸子植物红豆杉的树皮分离提纯的天然次生代谢产物，具有良好的抗肿瘤作用，特别是对癌症发病率较高的卵巢癌、子宫癌和乳腺癌等有特效。紫杉醇是近年国际市场上最热门的抗癌药物，被认为是人类未来20年间最有效的抗癌药物之一。Paclitaxel is a natural secondary metabolite isolated and purified from the bark of the gymnosperm Taxus chinensis. It has good anti-tumor effects, especially for ovarian cancer, uterine cancer and breast cancer, which have a high incidence of cancer. Paclitaxel is the most popular anticancer drug on the international market in recent years, and is considered to be one of the most effective anticancer drugs for mankind in the next 20 years.
现有保健品领域中，常用一些红豆杉的枝叶制作药包、枕头和床垫等具有预防作用的保健器械。但是，此类保健器械对红豆杉中有效成分的利用率较低，并且也不方便携带。In the field of existing health care products, some branches and leaves of Taxus chinensis are commonly used to make health care devices with preventive effects such as medicine bags, pillows and mattresses. However, such health care devices have low utilization rates of the active ingredients in Taxus chinensis, and are also inconvenient to carry.
有鉴于此，特提出本发明。In view of this, the present invention is proposed.
发明内容SUMMARY OF THE INVENTION
本发明的第一目的在于提供一种紫杉醇药包，以完全或部分解决上述问题，所述的紫杉醇药包中，包裹有高纯度的紫杉醇，并在药包袋外侧设置有放射能量片，利用其放射出的能量射线激发紫杉醇，有助于抑制癌细胞的生成，并且通过能量射线加上人体温度产生的热量穿透过布料进入到人体内的细胞中，起到有病症可起到治疗作用，无病可起到预防作用。The first object of the present invention is to provide a paclitaxel medicine bag to solve the above problems completely or partially. The energy rays it emits stimulate paclitaxel, which helps to inhibit the formation of cancer cells, and the heat generated by the energy rays and the body temperature penetrates through the cloth and enters the cells in the human body, which can play a therapeutic role in the treatment of diseases. , disease-free can play a preventive role.
本发明的第二目的在于提供一种所述的紫杉醇药包的制备方法，该方法通过采用红豆杉制备高纯度的紫杉醇，然后制备成具有一定医疗保健功效的紫杉醇药包，具有方便、简单、适合批量生产等优点。The second object of the present invention is to provide a preparation method of the described paclitaxel drug pack, the method prepares high-purity paclitaxel by using Taxus chinensis, and then prepares the paclitaxel drug pack with certain medical and health care effects, which is convenient, simple, Suitable for mass production and other advantages.
本发明的第三目的在于提供一种所述的紫杉醇药包的用途，该用途可以将所紫杉醇药包放置在女性内衣裤内，将没有放射能量片的一次面向人体，起到对乳腺癌和卵巢癌的预防和治疗作用。The third object of the present invention is to provide a use of the paclitaxel drug pack, which can place the paclitaxel drug pack in women's underwear, and face the human body without a radioactive energy tablet once, so as to prevent breast cancer and Prevention and treatment of ovarian cancer.
为了实现本发明的上述目的，特采用以下技术方案：In order to realize the above-mentioned purpose of the present invention, the following technical solutions are specially adopted:
一种紫杉醇药包，包括药包袋和被包覆在所述药包袋内的紫杉醇，所述药包本体外一侧设置有放射能量片；A paclitaxel medicine bag, comprising a medicine bag and paclitaxel coated in the medicine bag, and a radioactive energy tablet is arranged on the outer side of the medicine bag body;
其中，以药包袋的面积计，每平方米所述药包袋内装有2~3kg紫杉醇。Wherein, in terms of the area of the medicine bag, each square meter of the medicine bag contains 2~3kg of paclitaxel.
优选的，所述紫杉醇为红豆杉的提取物，所述紫杉醇的纯度大于99.5%。Preferably, the taxol is an extract of Taxus chinensis, and the purity of the taxol is greater than 99.5%.
优选的，所述红豆杉的提取物为红豆杉的枝、叶、茎、皮、根中至少一种的提取物。Preferably, the extract of Taxus chinensis is the extract of at least one of the branches, leaves, stems, bark and roots of Taxus chinensis.
优选的，所述药包袋的材质选自纳米银纤维面料、纳米级铝箔和纳米布中的一种。Preferably, the material of the medicine bag is selected from one of nano-silver fiber fabric, nano-scale aluminum foil and nano-cloth.
优选的，所述药包袋的形状为正方形、圆形、长方形、三角形、圆形、梯形、菱形或不规则多边形中的一种；Preferably, the shape of the medicine bag is one of square, circle, rectangle, triangle, circle, trapezoid, rhombus or irregular polygon;
更优选的，所述药包袋的面积为30~60平方厘米。More preferably, the area of the medicine bag is 30-60 square centimeters.
优选的，所述放射能量片的数量至少为3。Preferably, the number of the radioactive energy sheets is at least three.
优选的，所述药包袋内还包括中药材，所述中药材包括丹参、银杏叶、菊花、葛根、薰衣草和白芷中的一种或者几种。Preferably, the medicine bag further includes Chinese medicinal materials, and the traditional Chinese medicinal materials include one or more of Salvia miltiorrhiza, ginkgo biloba, chrysanthemum, pueraria, lavender and angelica.
所述的紫杉醇药包的制备方法，包括以下步骤：The preparation method of the described paclitaxel medicine bag comprises the following steps:
a）、将清洗干净的枝、叶、茎、皮、根进行超微粉碎，然后干燥至水分小于3%；a), superfinely pulverize the cleaned branches, leaves, stems, bark, and roots, and then dry to a moisture content of less than 3%;
b）、将步骤a）得到的干燥后红豆杉进行超临界萃取，萃取物喷雾干燥，得到紫杉醇纯度大于99.5%的提取物；b), performing supercritical extraction on the dried Taxus chinensis obtained in step a), and spray-drying the extract to obtain an extract with a taxol purity greater than 99.5%;
c）、将步骤b）得到的所述提取物装入预制好的外侧带有放射能量片的药包袋中，并进行封口，得到所述紫杉醇药包。c), putting the extract obtained in step b) into a prefabricated medicine bag with a radioactive energy tablet on the outside, and sealing it to obtain the paclitaxel medicine bag.
优选的，在步骤a）中，在所述超微粉碎之前，还包括：将新鲜红豆杉的枝、叶、茎、皮、根中的至少一种清洗干净。Preferably, in step a), before the ultrafine pulverization, the method further comprises: cleaning at least one of the branches, leaves, stems, barks and roots of fresh yew.
优选的，在步骤c）中，将步骤b）得到的所述提取物和粉碎后的中药材装入预制好的外侧带有放射能量片的药包袋中。Preferably, in step c), the extract obtained in step b) and the pulverized Chinese medicinal materials are put into a prefabricated medicine bag with a radioactive energy tablet on the outside.
所述的紫杉醇药包在制备女性内衣裤中的用途。The use of the paclitaxel medicine package in the preparation of women's underwear.
与现有技术相比，本发明的有益效果为：Compared with the prior art, the beneficial effects of the present invention are:
（1）本发明所提供的一种紫杉醇药包，包裹有高纯度的紫杉醇，并在袋外侧设置有放射能量片，利用其放射出的能量射线激发紫杉醇，有助于抑制癌细胞的生成，并且通过能量射线加上人体温度产生的热量穿透过布料进入到人体内的细胞中，起到有病症可起到治疗作用，无病可起到预防作用。(1) A paclitaxel medicine bag provided by the present invention is wrapped with high-purity paclitaxel, and a radioactive energy tablet is arranged on the outside of the bag. Moreover, the heat generated by the energy rays and the temperature of the human body penetrates through the cloth and enters the cells in the human body.
（2）本发明所提供的紫杉醇药包的制备方法，通过采用红豆杉制备高纯度的紫杉醇，然后制备成具有一定医疗保健功效的紫杉醇药包，具有方便、简单、适合批量生产等优点。(2) The preparation method of the paclitaxel drug pack provided by the present invention is to prepare high-purity paclitaxel by using Taxus chinensis, and then prepare the paclitaxel drug pack with certain medical and health care effects, which has the advantages of convenience, simplicity, and suitability for mass production.
（3）本发明所提供的紫杉醇药包的用途，将所紫杉醇药包放置在女性内衣裤内，将没有放射能量片的一次面向人体，起到对乳腺癌和卵巢癌的预防和治疗作用。(3) The use of the paclitaxel drug pack provided by the present invention, the paclitaxel drug pack is placed in women's underwear, and the tablet without radioactive energy is faced to the human body once, so as to prevent and treat breast cancer and ovarian cancer.
具体实施方式Detailed ways
下面将结合具体实施方式对本发明的技术方案进行清楚、完整地描述，但是本领域技术人员将会理解，下列所描述的实施例是本发明一部分实施例，而不是全部的实施例，仅用于说明本发明，而不应视为限制本发明的范围。基于本发明中的实施例，本领域普通技术人员在没有做出创造性劳动前提下所获得的所有其他实施例，都属于本发明保护的范围。实施例中未注明具体条件者，按照常规条件或制造商建议的条件进行。所用试剂或仪器未注明生产厂商者，均为可以通过市售购买获得的常规产品。The technical solutions of the present invention will be clearly and completely described below with reference to the specific embodiments, but those skilled in the art will understand that the embodiments described below are part of the embodiments of the present invention, not all of the embodiments, and are only used for The present invention is described and should not be considered as limiting the scope of the present invention. Based on the embodiments of the present invention, all other embodiments obtained by those of ordinary skill in the art without creative efforts shall fall within the protection scope of the present invention. If the specific conditions are not indicated in the examples, it is carried out according to the conventional conditions or the conditions suggested by the manufacturer. The reagents or instruments used without the manufacturer's indication are conventional products that can be purchased from the market.
本发明所提供的一种紫杉醇药包，包括药包袋和被包覆在所述药包袋内的紫杉醇，所述药包本体外一侧设置有放射能量片；A paclitaxel medicine bag provided by the present invention comprises a medicine bag and paclitaxel coated in the medicine bag, and a radioactive energy tablet is arranged on the outer side of the medicine bag body;
其中，以药包袋的面积计，每平方米所述药包袋内装有2~3kg紫杉醇。Wherein, in terms of the area of the medicine bag, each square meter of the medicine bag contains 2~3kg of paclitaxel.
本发明所提供的一种紫杉醇药包，包裹有高纯度的紫杉醇，并在袋外侧设置有放射能量片，利用其放射出的能量射线激发紫杉醇，有助于抑制癌细胞的生成，并且通过能量射线加上人体温度产生的热量穿透过布料进入到人体内的细胞中，起到有病症可起到治疗作用，无病可起到预防作用。The paclitaxel medicine bag provided by the present invention is wrapped with high-purity paclitaxel, and a radioactive energy tablet is arranged on the outside of the bag. The heat generated by the rays and the temperature of the human body penetrates through the cloth and enters the cells in the human body, which can play a therapeutic role in the disease, and can play a preventive role in the absence of the disease.
在本发明一些优选的实施例中，所述紫杉醇为红豆杉的提取物，所述紫杉醇的纯度大于99.5%。In some preferred embodiments of the present invention, the taxol is an extract of Taxus chinensis, and the purity of the taxol is greater than 99.5%.
优选的，所述红豆杉的提取物为红豆杉的枝、叶、茎、皮、根中至少一种的提取物。Preferably, the extract of Taxus chinensis is the extract of at least one of the branches, leaves, stems, bark and roots of Taxus chinensis.
红豆杉，别称扁柏、红豆树、紫衫，味微甘，性平，全身都可以入药，分布于北半球，是世界上公认濒临灭绝的天然珍稀抗癌植物，是第四纪冰川遗留下来的古老树种，在地球上已有250万年的历史。由于在自然条件下红豆杉生长速度缓慢，再生能力差，所以很长时间以来，世界范围内还没有形成大规模红豆杉原料林基地。Taxus, also known as cypress, red bean, and yew, has a slightly sweet taste and a flat nature. It can be used as medicine all over the body. It is distributed in the northern hemisphere. It is a natural and rare anti-cancer plant recognized as endangered in the world. Tree species have a history of 2.5 million years on the earth. Due to the slow growth rate and poor regeneration ability of Taxus chinensis under natural conditions, a large-scale forest base of Taxus chinensis has not been formed in the world for a long time.
红豆杉也是我国国家一级保护植物。红豆杉的枝、叶、茎、皮、根中富含紫杉醇、蛋白质和钙、磷、铁等矿物质及多种维生素，是天然的抗氧化（抗衰老）植物。Taxus is also a national first-class protected plant in my country. The branches, leaves, stems, bark and roots of Taxus chinensis are rich in paclitaxel, protein, minerals such as calcium, phosphorus, iron and various vitamins, and are natural antioxidant (anti-aging) plants.
在本发明一些优选的实施例中，所述药包袋的材质选自纳米银纤维面料、纳米级铝箔和纳米布中的一种。In some preferred embodiments of the present invention, the material of the medicine bag is selected from one of nano-silver fiber fabric, nano-scale aluminum foil and nano-cloth.
纳米银纤维面料，能消除650种以上的病原体，抗菌、消炎、除异味，预防妇科疾病。而且我们的纳米银离子织入纤维中，不同于普通浸泡银离子工艺，耐水洗，功效持久。Nano-silver fiber fabric can eliminate more than 650 kinds of pathogens, antibacterial, anti-inflammatory, deodorant, and prevent gynecological diseases. Moreover, our nano silver ions are woven into the fibers, which is different from the ordinary soaking silver ion process, which is washable and has a long-lasting effect.
当布料到纳米尺度以后，大约是在0.1~100纳米这个范围空间，物质的性能就会发生突变，出现特殊性能。这种既具不同于原来组成的原子、分子，也不同于宏观的物质的特殊性能构成的材料，即为纳米布。纳米布是运用了纳米技术的布料，结构表面覆有一层化学物质，这层物质能够使布料上的水直接滑落，有防水作用。纳米布还有防污，防油，抗菌的作用。When the fabric reaches the nanometer scale, in the range of 0.1 to 100 nanometers, the properties of the material will undergo sudden changes and special properties will appear. This kind of material with special properties that are different from the original composition of atoms and molecules, and also different from the macroscopic substances, is called nano-cloth. Nano cloth is a cloth that uses nanotechnology. The surface of the structure is covered with a layer of chemical substances, which can make the water on the cloth slide off directly and has a waterproof effect. Nano cloth also has anti-fouling, anti-oil, anti-bacterial effects.
在本发明一些优选的实施例中，所述药包袋的形状为正方形、圆形、长方形、三角形、圆形、梯形、菱形或不规则多边形中的一种，适应于各种类型的衣裤配合使用；In some preferred embodiments of the present invention, the shape of the medicine bag is one of a square, a circle, a rectangle, a triangle, a circle, a trapezoid, a rhombus or an irregular polygon, which is suitable for various types of underwear With the use of;
更优选的，所述药包袋的面积为30~60平方厘米，方便携带。More preferably, the area of the medicine bag is 30-60 square centimeters, which is convenient to carry.
在本发明一些优选的实施例中，所述放射能量片的数量至少为3，以保证对于紫杉醇的激发效果。In some preferred embodiments of the present invention, the number of the radioactive energy sheets is at least 3 to ensure the excitation effect on paclitaxel.
在本发明一些优选的实施例中，所述药包袋内还包括中药材，以提高所述紫杉醇药包的保健效果，所述中药材包括丹参、银杏叶、菊花、葛根、薰衣草和白芷中的一种或者几种。In some preferred embodiments of the present invention, the medicine bag further includes Chinese medicinal materials, so as to improve the health care effect of the paclitaxel medicine pack, the traditional Chinese medicinal materials include Salvia miltiorrhiza, ginkgo biloba, chrysanthemum, pueraria, lavender and Angelica sinensis one or more of them.
本发明所提供的一种所述的紫杉醇药包的制备方法，包括以下步骤：The preparation method of a kind of described paclitaxel medicine bag provided by the present invention comprises the following steps:
a）、将清洗干净的枝、叶、茎、皮、根进行超微粉碎，然后干燥至水分小于3%；a), superfinely pulverize the cleaned branches, leaves, stems, bark, and roots, and then dry to a moisture content of less than 3%;
b）、将步骤a）得到的干燥后红豆杉进行超临界萃取，得到紫杉醇纯度大于99.5%的提取物；b), performing supercritical extraction on the dried Taxus chinensis obtained in step a) to obtain an extract with a taxol purity greater than 99.5%;
c）、将步骤b）得到的所述提取物装入预制好的外侧带有放射能量片的药包袋中，并进行封口，得到所述紫杉醇药包。c), putting the extract obtained in step b) into a prefabricated medicine bag with a radioactive energy tablet on the outside, and sealing it to obtain the paclitaxel medicine bag.
在本发明一些优选的实施例中，在步骤a）中，在所述超微粉碎之前，还包括：将新鲜红豆杉的枝、叶、茎、皮、根中的至少一种清洗干净。In some preferred embodiments of the present invention, in step a), before the ultrafine pulverization, the method further comprises: cleaning at least one of the branches, leaves, stems, bark and roots of fresh yew.
在本发明一些优选的实施例中，在步骤c）中，将步骤b）得到的所述提取物和粉碎后的中药材装入预制好的外侧带有放射能量片的药包袋中。In some preferred embodiments of the present invention, in step c), the extract obtained in step b) and the pulverized Chinese medicinal material are packed into a prefabricated medicine bag with radioactive energy tablets on the outside.
本发明所提供的一种所述的紫杉醇药包在制备女性内衣裤中的用途。The present invention provides a use of the paclitaxel medicine package in preparing women's underwear.
下面将结合实施例对本发明的实施方案进行详细描述，但是本领域技术人员将会理解，下列实施例仅用于说明本发明，而不应视为限制本发明的范围。实施例中未注明具体条件者，按照常规条件或制造商建议的条件进行。所用试剂或仪器未注明生产厂商者，均为可以通过市购获得的常规产品。The embodiments of the present invention will be described in detail below with reference to the examples, but those skilled in the art will understand that the following examples are only used to illustrate the present invention and should not be regarded as limiting the scope of the present invention. If the specific conditions are not indicated in the examples, it is carried out according to the conventional conditions or the conditions suggested by the manufacturer. The reagents or instruments used without the manufacturer's indication are conventional products that can be obtained from the market.
实施例1Example 1
本发明所提供的紫杉醇药包，由以下方法制备得到：The paclitaxel medicine package provided by the present invention is prepared by the following method:
a）、将清洗干净的枝、叶、茎、皮、根进行超微粉碎，然后干燥至水分小于3%；a), superfinely pulverize the cleaned branches, leaves, stems, bark, and roots, and then dry to a moisture content of less than 3%;
b）、将步骤a）得到的干燥后红豆杉进行超临界萃取，萃取物喷雾干燥，得到紫杉醇纯度大于99.5%的提取物；b), performing supercritical extraction on the dried Taxus chinensis obtained in step a), and spray-drying the extract to obtain an extract with a taxol purity greater than 99.5%;
c）、将步骤b）得到的所述提取物装入预制好的外侧带有3个放射能量片的5×6cm的纳米银纤维面料的药包袋中，并进行封口，得到所述紫杉醇药包。c), put the extract obtained in step b) into a prefabricated 5×6 cm nano-silver fiber fabric medicine bag with 3 radioactive energy sheets on the outside, and seal it to obtain the paclitaxel medicine Bag.
该紫杉醇药包包括6g紫杉醇。The paclitaxel pack includes 6g of paclitaxel.
实施例2Example 2
本发明所提供的紫杉醇药包，由以下方法制备得到：The paclitaxel medicine package provided by the present invention is prepared by the following method:
a）、将清洗干净的枝、叶、茎、皮、根进行超微粉碎，然后干燥至水分小于3%；a), superfinely pulverize the cleaned branches, leaves, stems, bark, and roots, and then dry to a moisture content of less than 3%;
b）、将步骤a）得到的干燥后红豆杉进行超临界萃取，萃取物喷雾干燥，得到紫杉醇纯度大于99.5%的提取物；b), performing supercritical extraction on the dried Taxus chinensis obtained in step a), and spray-drying the extract to obtain an extract with a taxol purity greater than 99.5%;
c）、将步骤b）得到的所述提取物装入预制好的外侧带有3个放射能量片的5×5cm的纳米级铝箔的药包袋中，并进行封口，得到所述紫杉醇药包。c), put the extract obtained in step b) into a prefabricated 5×5 cm nano-scale aluminum foil medicine bag with 3 radioactive energy sheets on the outside, and seal it to obtain the paclitaxel medicine bag .
该紫杉醇药包包括7g紫杉醇。The paclitaxel pack includes 7g of paclitaxel.
实施例3Example 3
本发明所提供的紫杉醇药包，由以下方法制备得到：The paclitaxel medicine package provided by the present invention is prepared by the following method:
a）、将清洗干净的枝、叶、茎、皮、根进行超微粉碎，然后干燥至水分小于3%；a), superfinely pulverize the cleaned branches, leaves, stems, bark, and roots, and then dry to a moisture content of less than 3%;
b）、将步骤a）得到的干燥后红豆杉进行超临界萃取，萃取物喷雾干燥，得到紫杉醇纯度大于99.5%的提取物；b), performing supercritical extraction on the dried Taxus chinensis obtained in step a), and spray-drying the extract to obtain an extract with a taxol purity greater than 99.5%;
c）、将步骤b）得到的所述提取物和中药材装入预制好的外侧带有4个放射能量片的5×5cm的纳米级铝箔的药包袋中，并进行封口，得到所述紫杉醇药包。c), put the extract and Chinese medicinal materials obtained in step b) into a prefabricated 5×5 cm nano-scale aluminum foil medicine bag with 4 radioactive energy sheets on the outside, and seal it to obtain the Paclitaxel package.
该紫杉醇药包包括6g紫杉醇和中药材5g；The paclitaxel medicine pack includes 6 g of paclitaxel and 5 g of Chinese medicinal materials;
其中，所述中药材包括丹参、银杏叶、菊花、葛根、薰衣草和白芷。Wherein, the Chinese medicinal materials include Salvia miltiorrhiza, ginkgo biloba, chrysanthemum, pueraria, lavender and angelica.
实施例4Example 4
本发明所提供的紫杉醇药包，由以下方法制备得到：The paclitaxel medicine package provided by the present invention is prepared by the following method:
a）、将清洗干净的枝、叶、茎、皮、根进行超微粉碎，然后干燥至水分小于3%；a), superfinely pulverize the cleaned branches, leaves, stems, bark, and roots, and then dry to a moisture content of less than 3%;
b）、将步骤a）得到的干燥后红豆杉进行超临界萃取，萃取物喷雾干燥，得到紫杉醇纯度大于99.5%的提取物；b), performing supercritical extraction on the dried Taxus chinensis obtained in step a), and spray-drying the extract to obtain an extract with a taxol purity greater than 99.5%;
c）、将步骤b）得到的所述提取物和中药材装入预制好的外侧带有3个放射能量片的50平方厘米的纳米布的药包袋中，并进行封口，得到所述紫杉醇药包。c), put the extract and Chinese medicinal materials obtained in step b) into a prefabricated 50 square centimeter nanocloth medicine bag with 3 radioactive energy sheets on the outside, and seal it to obtain the paclitaxel medicine pack.
该紫杉醇药包包括10g紫杉醇和中药材6g。The paclitaxel medicine pack includes 10 g of paclitaxel and 6 g of Chinese medicinal materials.
其中，所述中药材包括丹参、银杏叶、菊花、葛根、薰衣草和白芷。Wherein, the Chinese medicinal materials include Salvia miltiorrhiza, ginkgo biloba, chrysanthemum, pueraria, lavender and angelica.
实施例5Example 5
本发明所提供的紫杉醇药包，由以下方法制备得到：The paclitaxel medicine package provided by the present invention is prepared by the following method:
a）、将清洗干净的枝、叶、茎、皮、根进行超微粉碎，然后干燥至水分小于3%；a), superfinely pulverize the cleaned branches, leaves, stems, bark, and roots, and then dry to a moisture content of less than 3%;
b）、将步骤a）得到的干燥后红豆杉进行超临界萃取，萃取物喷雾干燥，得到紫杉醇纯度大于99.5%的提取物；b), performing supercritical extraction on the dried Taxus chinensis obtained in step a), and spray-drying the extract to obtain an extract with a taxol purity greater than 99.5%;
c）、将步骤b）得到的所述提取物和中药材装入预制好的外侧带有4个放射能量片的40平方厘米的纳米布的药包袋中，并进行封口，得到所述紫杉醇药包。c), put the extract and Chinese medicinal materials obtained in step b) into a prefabricated 40 square centimeter nanocloth medicine bag with 4 radioactive energy sheets on the outside, and seal it to obtain the paclitaxel medicine pack.
该紫杉醇药包包括11g紫杉醇和中药材3g。The paclitaxel medicine pack includes 11 g of paclitaxel and 3 g of Chinese medicinal materials.
其中，所述中药材包括丹参、银杏叶、菊花、葛根、薰衣草和白芷。Wherein, the Chinese medicinal materials include Salvia miltiorrhiza, ginkgo biloba, chrysanthemum, pueraria, lavender and angelica.
实施例6Example 6
本发明所提供的紫杉醇药包，由以下方法制备得到：The paclitaxel medicine package provided by the present invention is prepared by the following method:
a）、将清洗干净的枝、叶、茎、皮、根进行超微粉碎，然后干燥至水分小于3%；a), superfinely pulverize the cleaned branches, leaves, stems, bark, and roots, and then dry to a moisture content of less than 3%;
b）、将步骤a）得到的干燥后红豆杉进行超临界萃取，萃取物喷雾干燥，得到紫杉醇纯度大于99.5%的提取物；b), performing supercritical extraction on the dried Taxus chinensis obtained in step a), and spray-drying the extract to obtain an extract with a taxol purity greater than 99.5%;
c）、将步骤b）得到的所述提取物和中药材装入预制好的外侧带有4个放射能量片的60平方厘米的纳米银纤维面料的药包袋中，并进行封口，得到所述紫杉醇药包。c), put the extract and Chinese medicinal materials obtained in step b) into a prefabricated 60 square centimeter nano-silver fiber fabric medicine bag with 4 radioactive energy sheets on the outside, and seal them to obtain the Paclitaxel package.
该紫杉醇药包包括18g紫杉醇和中药材6g。The paclitaxel medicine pack includes 18 g of paclitaxel and 6 g of Chinese medicinal materials.
其中，所述中药材包括丹参、银杏叶、菊花、葛根、薰衣草和白芷。Wherein, the Chinese medicinal materials include Salvia miltiorrhiza, ginkgo biloba, chrysanthemum, pueraria, lavender and angelica.
综上所述，本发明所提供的一种紫杉醇药包，包裹有高纯度的紫杉醇，并在袋外侧设置有放射能量片，利用其放射出的能量射线激发紫杉醇，有助于抑制癌细胞的生成，并且通过能量射线加上人体温度产生的热量穿透过布料进入到人体内的细胞中，起到有病症可起到治疗作用，无病可起到预防作用。将所紫杉醇药包放置在女性内衣裤内，将没有放射能量片的一次面向人体，起到对乳腺癌和卵巢癌的预防和治疗作用。To sum up, the paclitaxel medicine bag provided by the present invention is wrapped with high-purity paclitaxel, and a radioactive energy sheet is arranged on the outside of the bag, and the energy rays emitted by the paclitaxel are used to excite the paclitaxel, which is helpful for inhibiting the growth of cancer cells. It is generated, and the heat generated by energy rays and human body temperature penetrates through the cloth and enters the cells in the human body, which can play a therapeutic role in the presence of diseases, and can play a preventive role in the absence of diseases. The paclitaxel medicine package is placed in women's underwear, and the one without radioactive energy tablet is faced to the human body, so as to prevent and treat breast cancer and ovarian cancer.
尽管已用具体实施例来说明和描述了本发明，然而应意识到，以上各实施例仅用以说明本发明的技术方案，而非对其限制；本领域的普通技术人员应当理解：在不背离本发明的精神和范围的情况下，可以对前述各实施例所记载的技术方案进行修改，或者对其中部分或者全部技术特征进行等同替换；而这些修改或者替换，并不使相应技术方案的本质脱离本发明各实施例技术方案的范围；因此，这意味着在所附权利要求中包括属于本发明范围内的所有这些替换和修改。Although the present invention has been illustrated and described with specific embodiments, it should be appreciated that the above embodiments are only used to illustrate the technical solutions of the present invention, but not to limit them; those of ordinary skill in the art should understand that: In the case of departing from the spirit and scope of the present invention, the technical solutions described in the foregoing embodiments may be modified, or some or all of the technical features thereof may be equivalently replaced; and these modifications or replacements do not make the corresponding technical solutions. Essentially depart from the scope of the technical solutions of the embodiments of the present invention; therefore, it is intended that all such substitutions and modifications that fall within the scope of the present invention be included in the appended claims.
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201911230900.4ACN111298113A (en) | 2019-12-05 | 2019-12-05 | A kind of paclitaxel medicine bag and its preparation method and use |
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201911230900.4ACN111298113A (en) | 2019-12-05 | 2019-12-05 | A kind of paclitaxel medicine bag and its preparation method and use |
| Publication Number | Publication Date |
|---|---|
| CN111298113Atrue CN111298113A (en) | 2020-06-19 |
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201911230900.4APendingCN111298113A (en) | 2019-12-05 | 2019-12-05 | A kind of paclitaxel medicine bag and its preparation method and use |
| Country | Link |
|---|---|
| CN (1) | CN111298113A (en) |
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113619218A (en)* | 2021-08-11 | 2021-11-09 | 郑建国 | Taxus chinensis filler containing paclitaxel inner core and preparation and application of cloth |
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20090060970A1 (en)* | 1997-09-26 | 2009-03-05 | Toner John L | Compositions and methods of administering paclitaxel with other drugs using medical devices |
| CN101862501A (en)* | 2010-06-07 | 2010-10-20 | 成都市知春红豆杉种植专业合作社 | Medicine bag containing taxus chinensis leaves and taxus chinensis leaf treating and processing devices |
| CN202636281U (en)* | 2012-07-03 | 2013-01-02 | 杭州豆杉红家居用品有限公司 | Yew slow-release fitness mattress |
| CN103750689A (en)* | 2013-12-21 | 2014-04-30 | 江西省喜果绿化有限公司 | Chinese yew traditional Chinese medicine health care pillow and production method thereof |
| CN106510351A (en)* | 2017-01-04 | 2017-03-22 | 上海紫醇生物科技有限公司 | Chinese yew traditional Chinese medicine sleep pillow |
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20090060970A1 (en)* | 1997-09-26 | 2009-03-05 | Toner John L | Compositions and methods of administering paclitaxel with other drugs using medical devices |
| CN101862501A (en)* | 2010-06-07 | 2010-10-20 | 成都市知春红豆杉种植专业合作社 | Medicine bag containing taxus chinensis leaves and taxus chinensis leaf treating and processing devices |
| CN202636281U (en)* | 2012-07-03 | 2013-01-02 | 杭州豆杉红家居用品有限公司 | Yew slow-release fitness mattress |
| CN103750689A (en)* | 2013-12-21 | 2014-04-30 | 江西省喜果绿化有限公司 | Chinese yew traditional Chinese medicine health care pillow and production method thereof |
| CN106510351A (en)* | 2017-01-04 | 2017-03-22 | 上海紫醇生物科技有限公司 | Chinese yew traditional Chinese medicine sleep pillow |
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113619218A (en)* | 2021-08-11 | 2021-11-09 | 郑建国 | Taxus chinensis filler containing paclitaxel inner core and preparation and application of cloth |
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| SE01 | Entry into force of request for substantive examination | ||
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| RJ01 | Rejection of invention patent application after publication | Application publication date:20200619 |