技术领域Technical field
本发明属于医疗器械领域，具体涉及一种可穿戴式癫痫监测设备。The invention belongs to the field of medical devices, and specifically relates to a wearable epilepsy monitoring device.
背景技术Background technique
癫痫是由于异常和过度的大脑神经元活动引起的慢性神经系统疾病，其中EEG信号是检测癫痫最常用和最有效的方法。Epilepsy is a chronic neurological disease caused by abnormal and excessive brain neuron activity, in which EEG signals are the most commonly used and effective method for detecting epilepsy.
癫痫患者通常对抗癫痫药物反应不佳，而且长期的服用药物会严重影响患者的身体，如果不及时服药很容易癫痫发作。手术切除癫痫病灶区是治疗癫痫比较有效的方法，但是对于癫痫区域比较大或位置不便于手术时该方法就遇到了困难。Patients with epilepsy usually do not respond well to anti-epileptic drugs, and long-term use of drugs can seriously affect the patient's body. If the drug is not taken in time, epileptic seizures are likely to occur. Surgical removal of the epileptic focus area is a more effective method for treating epilepsy, but this method encounters difficulties when the epileptic area is large or the location is inconvenient for surgery.
因此，有必要发明一种设备能够及时的提醒患者通过手动或者自动的方式进行电刺激的方式避免或者减少癫痫的发作。Therefore, it is necessary to invent a device that can promptly remind patients to avoid or reduce epileptic seizures through manual or automatic electrical stimulation.
发明内容Contents of the invention
鉴于上述技术问题，本发明提供了一种可穿戴式癫痫监测设备，旨在能够在癫痫发作之前检测到脑电信号的变化，同时自动或手动的控制电极进行刺激，减少癫痫的发作，保护大脑。In view of the above technical problems, the present invention provides a wearable epilepsy monitoring device, which is designed to detect changes in brain electrical signals before the onset of epilepsy, and at the same time automatically or manually control electrodes to stimulate, reduce the onset of epilepsy, and protect the brain. .
为解决上述技术问题，本发明的技术方案如下：In order to solve the above technical problems, the technical solutions of the present invention are as follows:
一种可穿戴式癫痫监测设备，所述癫痫监测设备包括植入式电极装置1、固定盖2和穿戴装置3，所述植入式电极装置1用于固定在事先已经确定的癫痫病灶区处的颅骨上，所述固定盖2设置在植入式电极装置1上，与植入式电极装置1连接，所述固定盖2内部设置有微处理器、电源、蓝牙模块、无线通讯装置和无线充电模块，所述微处理器用于处理植入式电极装置1测量的数据，然后通过无线通讯装置将所述数据发送到云端，并接收云端处理的结果，微处理器根据所述结果判断是否需要控制电极进行电刺激，同时微处理器通过蓝牙模块将所述结果发送到穿戴装置3，所述穿戴装置3提醒患者是否需要持续进行手动的脑刺激，所述穿戴装置3设置在患者的腕部。A wearable epilepsy monitoring device. The epilepsy monitoring device includes an implanted electrode device 1, a fixing cover 2 and a wearing device 3. The implanted electrode device 1 is used to be fixed at a previously determined epilepsy focus area. On the skull, the fixed cover 2 is arranged on the implantable electrode device 1 and is connected to the implantable electrode device 1. The fixed cover 2 is equipped with a microprocessor, a power supply, a Bluetooth module, a wireless communication device and a wireless Charging module, the microprocessor is used to process the data measured by the implanted electrode device 1, and then sends the data to the cloud through the wireless communication device, and receives the results of the cloud processing. The microprocessor determines whether it is necessary based on the results. The electrodes are controlled to perform electrical stimulation, and at the same time, the microprocessor sends the results to the wearable device 3 through the Bluetooth module. The wearable device 3 reminds the patient whether he or she needs to continue manual brain stimulation. The wearable device 3 is set on the patient's wrist. .
进一步地，所述植入式电极装置1中心处设置第一电极1.1，所述第一电极1.1上部设置有上支撑架1.2，所述上支撑架1.2的端部设置有上夹持端 1.4，所述上夹持端1.4的空腔内安装有上圆轴1.3，所述第一电极1.1的下部设置有下支撑架1.5，所述下支撑架1.5的端部设置下圆轴1.6，活动杆1.7 的上部设置上滑槽1.8，下部设置下滑槽1.9，所述上滑槽1.8与上圆轴1.3 配合，所述下滑槽1.9与下圆轴1.6配合，所述上滑槽1.8具有第一叉部1.12 和第二叉部1.13，所述第二叉部1.13上端设置连接端1.14，所述活动杆1.7 的下部侧面设置下夹持端1.10，所述活动杆1.7的下端固定第二电极1.11，所述第一电极1.1和第二电极1.11均通过连接线1.15与微处理器连接，所述连接端1.14上设置螺纹，与固定盖上的螺纹配合，上夹持端1.4和下夹持端1.10上设置有防滑凸起。Further, a first electrode 1.1 is provided at the center of the implantable electrode device 1, an upper support frame 1.2 is provided on the upper part of the first electrode 1.1, and an upper clamping end 1.4 is provided at the end of the upper support frame 1.2, An upper circular shaft 1.3 is installed in the cavity of the upper clamping end 1.4, a lower support frame 1.5 is provided at the lower part of the first electrode 1.1, a lower circular shaft 1.6 is provided at the end of the lower support frame 1.5, and a movable rod The upper part of 1.7 is provided with an upper chute 1.8, and the lower part is provided with a lower chute 1.9. The upper chute 1.8 cooperates with the upper circular shaft 1.3, the lower chute 1.9 cooperates with the lower circular shaft 1.6, and the upper chute 1.8 has a first fork. part 1.12 and the second fork part 1.13, the upper end of the second fork part 1.13 is provided with a connecting end 1.14, the lower side of the movable rod 1.7 is provided with a lower clamping end 1.10, the lower end of the movable rod 1.7 is fixed with the second electrode 1.11, The first electrode 1.1 and the second electrode 1.11 are both connected to the microprocessor through a connecting wire 1.15. The connecting end 1.14 is provided with threads to cooperate with the threads on the fixed cover. The upper clamping end 1.4 and the lower clamping end 1.10 Anti-slip bulges are provided on the top.
进一步地，所述穿戴装置3具有外壳3.1，所述外壳3.1上设置第一显示屏3.2和第二显示屏3.3，在显示屏的周围设置提示灯3.4，在提示灯3.4的外侧设置与各提示灯3.4对应的按钮3.5，所述提示灯3.4设置有多个，并相应的表示多个不同的时间等级，按压按钮3.5表示选择相应的刺激时间，外壳3.1的侧面设置旋钮3.6，所述旋钮3.6用于调节电刺激的强度和频率，并将强度和频率分别通过第一显示屏3.2和第二显示屏3.3显示，在与旋钮3.6 相对的外壳3.1的另一侧上设置喇叭3.7，所述外壳3.1的背面设置震动头 3.8。Further, the wearable device 3 has a shell 3.1, a first display screen 3.2 and a second display screen 3.3 are provided on the shell 3.1, a prompt light 3.4 is provided around the display screen, and each prompt is provided outside the prompt light 3.4. The light 3.4 corresponds to the button 3.5. There are multiple prompt lights 3.4, and correspondingly represent multiple different time levels. Pressing the button 3.5 indicates selecting the corresponding stimulation time. A knob 3.6 is provided on the side of the housing 3.1. The knob 3.6 For adjusting the intensity and frequency of electrical stimulation, and displaying the intensity and frequency through the first display screen 3.2 and the second display screen 3.3 respectively, a speaker 3.7 is provided on the other side of the housing 3.1 opposite to the knob 3.6, and the housing is A vibrating head 3.8 is installed on the back of the 3.1.
进一步地，所述植入式电极装置1获取癫痫病灶区处的脑电信号后发送到固定盖2内部的微处理器上，微处理器进行如下处理：Further, the implantable electrode device 1 acquires the EEG signals at the epileptic focus area and sends them to the microprocessor inside the fixed cover 2. The microprocessor performs the following processing:
首先，利用四层小波变换结合三阶Daubechies小波函数对其去噪重构；First, use four-layer wavelet transform combined with the third-order Daubechies wavelet function to denoise and reconstruct it;
其次，对去噪重构后的脑电信号进行互补集合经验模态分解CEEMD，将脑电信号分解为本征模态分量IMF，并且提取包含大部分脑电信号能量的第三和第四IMF分量将其作为主要的IMF；Secondly, the complementary ensemble empirical mode decomposition (CEEMD) is performed on the denoised and reconstructed EEG signal to decompose the EEG signal into the intrinsic modal components IMF, and extract the third and fourth IMF that contain most of the EEG signal energy. The component treats it as the main IMF;
接着，对这两个主要的IMF分量进行相空间重构，对这两个主要的IMF 分量进行相空间重构后计算欧几里德距离ED，用于推导特征，所述特征信号证明了癫痫患者癫痫先兆期的脑电信号模式与其他状态脑电信号模式存在显着差异；Then, the phase space of the two main IMF components is reconstructed, and the Euclidean distance ED is calculated after the phase space reconstruction of the two main IMF components, which is used to derive features. The characteristic signal proves that epilepsy There is a significant difference between the EEG signal pattern of patients in the epilepsy aura stage and other states;
然后，将推导得到的特征信号通过固定盖2的无线通讯装置发送到云端，作为RBF神经网络的输入信号，并利用神经网络构建一组动态估计器，计算输入信号与云端存储的数据库中脑电信号模式之间的差异；Then, the derived characteristic signal is sent to the cloud through the wireless communication device of the fixed cover 2 as the input signal of the RBF neural network, and a set of dynamic estimators are constructed using the neural network to calculate the input signal and the EEG in the database stored in the cloud. Differences between signaling modes;
若输入信号与数据库中的癫痫发作先兆期信号差异最小，则该输入信号判断为癫痫发作先兆期信号；若输入信号与数据库中的癫痫发作间期信号差异最小，则该输入信号判断为癫痫发作间期信号；若输入信号与数据库中的癫痫发作期信号差异最小，则该输入信号判断为癫痫发作期信号；If the difference between the input signal and the epileptic seizure precursor phase signal in the database is the smallest, the input signal is judged to be the epileptic seizure precursor phase signal; if the input signal has the smallest difference to the epileptic seizure interictal signal in the database, the input signal is judged to be an epileptic seizure. Interval signal; if the difference between the input signal and the epileptic seizure signal in the database is minimal, the input signal is judged to be the epileptic seizure signal;
对于判断为癫痫发作先兆期的信号，云端将该判断结果发送回固定盖2 内部的微处理器，进行脑刺激。For signals judged to be in the premonitory stage of epileptic seizures, the cloud sends the judgment results back to the microprocessor inside the fixed cover 2 for brain stimulation.
进一步地，所述其他状态为癫痫发作间期和癫痫发作期，所述脑电信号模式包括癫痫发作先兆期信号、癫痫发作间期信号和癫痫发作期信号。Further, the other states are epileptic interictal periods and epileptic seizure periods, and the brain electrical signal patterns include epileptic seizure aura phase signals, epileptic seizure interictal signals, and epileptic seizure phase signals.
进一步地，所述穿戴装置3通过提示灯3.4闪烁、喇叭3.7发出提示音和震动头3.8震动的方式告知癫痫患者。Further, the wearable device 3 notifies the epilepsy patient by flashing the prompt light 3.4, emitting a prompt sound from the horn 3.7, and vibrating the vibrating head 3.8.
进一步地，所述上支撑架1.2、下支撑架1.5和活动杆1.7环绕第一电极 1.1均匀设置有多个；优选为4-12个。Further, a plurality of upper support frames 1.2, lower support frames 1.5 and movable rods 1.7 are evenly arranged around the first electrode 1.1; preferably 4-12.
进一步地，所述下夹持端1.10为弹性体，在将植入式电极装置1插入到颅骨开设的孔中时，下夹持端1.10可被压缩产生形变，在插入之后恢复，并且在夹持时是柔性夹持。Furthermore, the lower clamping end 1.10 is an elastic body. When the implantable electrode device 1 is inserted into the hole opened in the skull, the lower clamping end 1.10 can be compressed to deform, recover after insertion, and be clamped. The holding time is flexible clamping.
与现有技术相比，本发明具有以下有益效果：本发明安装方便，减少患者的手术痛苦；在需要更换时能够比较快速的取下，对患者的脑部伤害较小；本发明控制方便，能够在癫痫发作前提醒患者或自动进行脑部刺激，达到控制癫痫不发作，减少癫痫发作的次数，保护大脑。Compared with the prior art, the present invention has the following beneficial effects: the present invention is easy to install and reduces the patient's surgical pain; it can be removed relatively quickly when replacement is needed, causing less damage to the patient's brain; the present invention is easy to control, It can remind patients before epileptic seizures or automatically perform brain stimulation to control epilepsy, reduce the number of epileptic seizures, and protect the brain.
附图说明Description of the drawings
图1本发明植入式电极装置结构示意图一；Figure 1 is a schematic structural diagram of the implantable electrode device of the present invention;
图2本发明植入式电极装置结构示意图二；Figure 2 is a schematic diagram 2 of the structure of the implantable electrode device of the present invention;
图3本发明植入式电极装置结构示意图三；Figure 3 is a schematic structural diagram of the implantable electrode device of the present invention;
图4本发明活动杆结构示意图；Figure 4 is a schematic structural diagram of the movable lever of the present invention;
图5本发明支撑装置结构示意图；Figure 5 is a schematic structural diagram of the support device of the present invention;
图6本发明植入式电极装置俯视图一；Figure 6 is a top view of the implantable electrode device of the present invention;
图7本发明植入式电极装置俯视图二；Figure 7 Top view 2 of the implantable electrode device of the present invention;
图8本发明带有固定盖的植入式电极装置结构示意图；Figure 8 is a schematic structural diagram of the implantable electrode device with a fixed cover of the present invention;
图9本发明带有固定盖的植入式电极装置剖视图；Figure 9 is a cross-sectional view of the implantable electrode device with a fixed cover of the present invention;
图10本发明植入式电极装置活动杆旋转结构示意图；Figure 10 is a schematic diagram of the rotation structure of the movable rod of the implantable electrode device of the present invention;
图11本发明植入式电极装置活动杆旋转剖视图；Figure 11 is a cross-sectional view of the movable rod of the implantable electrode device of the present invention;
图12本发明植入式电极装置夹持在颅骨上的示意图；Figure 12 is a schematic diagram of the implantable electrode device of the present invention clamped on the skull;
图13本发明穿戴装置正面结构示意图；Figure 13 is a schematic diagram of the front structure of the wearable device of the present invention;
图14本发明穿戴装置右侧结构示意图；Figure 14 is a schematic structural diagram of the right side of the wearable device of the present invention;
图15本发明穿戴装置左侧结构示意图；Figure 15 is a schematic structural diagram of the left side of the wearable device of the present invention;
图16本发明穿戴装置后侧结构示意图；Figure 16 is a schematic structural diagram of the rear side of the wearable device of the present invention;
图中植入式电极装置1、第一电极1.1、上支撑架1.2、上圆轴1.3、上夹持端1.4、下支撑架1.5、下圆轴1.6、活动杆1.7、上滑槽1.8、下滑槽 1.9、下夹持端1.10、第二电极1.11、第一叉部1.12、第二叉部1.13、连接端1.14、连接线1.15、固定盖2、穿戴装置3、外壳3.1、第一显示屏3.2、第二显示屏3.3、提示灯3.4、按钮3.5、旋钮3.6、喇叭3.7、震动头3.8。In the figure, the implantable electrode device 1, the first electrode 1.1, the upper support frame 1.2, the upper circular shaft 1.3, the upper clamping end 1.4, the lower support frame 1.5, the lower circular shaft 1.6, the movable rod 1.7, the upper chute 1.8, and the lower slide Slot 1.9, lower clamping end 1.10, second electrode 1.11, first fork 1.12, second fork 1.13, connecting end 1.14, connecting wire 1.15, fixed cover 2, wearable device 3, housing 3.1, first display 3.2 , Second display screen 3.3, prompt light 3.4, button 3.5, knob 3.6, speaker 3.7, vibrating head 3.8.
具体实施方式Detailed ways
下面将结合本发明实施例中的附图，对本发明实施例中的技术方案进行清楚、完整地描述，显然，所描述的实施例仅仅是本发明一部分实施例，而不是全部的实施例。基于本发明中的实施例，本领域普通技术人员在没有做出创造性劳动前提下所获得的所有其他实施例，都属于本发明保护的范围。The technical solutions in the embodiments of the present invention will be clearly and completely described below with reference to the accompanying drawings in the embodiments of the present invention. Obviously, the described embodiments are only some of the embodiments of the present invention, rather than all the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by those of ordinary skill in the art without creative efforts fall within the scope of protection of the present invention.
在本发明的描述中，需要理解的是，术语“中心”、“长度”、“宽度”、“厚度”、“上”、“下”、“前”、“后”、“左”、“右”、“竖直”、“水平”、“顶”、“底”“内”、“外”、“轴向”、“周向”等指示的方位或位置关系为基于附图所示的方位或位置关系，仅是为了便于描述本发明和简化描述，而不是指示或暗示所指的装置或元件必须具有特定的方位、以特定的方位构造和操作，因此不能理解为对本发明的限制。In the description of the present invention, it should be understood that the terms "center", "length", "width", "thickness", "upper", "lower", "front", "back", "left", " The directions or positional relationships indicated by "right", "vertical", "horizontal", "top", "bottom", "inner", "outer", "axial", "circumferential", etc. are based on those shown in the accompanying drawings The orientation or positional relationship is only for the convenience of describing the present invention and simplifying the description. It does not indicate or imply that the device or element referred to must have a specific orientation, be constructed and operated in a specific orientation, and therefore cannot be understood as a limitation of the present invention.
在本发明中，除非另有明确的规定和限定，术语“设置”、“安装”、“相连”、“连接”、“固定”等术语应做广义理解，例如，可以是固定连接，也可以是可拆卸连接；可以是机械连接；可以是直接相连，也可以通过中间媒介间接相连。对于本领域的普通技术人员而言，可以根据具体情况理解上述术语在本发明中的具体含义。In the present invention, unless otherwise expressly stipulated and limited, the terms "set", "installation", "connected", "connected", "fixed" and other terms should be understood in a broad sense. For example, it can be a fixed connection or a fixed connection. It is a detachable connection; it can be a mechanical connection; it can be directly connected or indirectly connected through an intermediate medium. For those of ordinary skill in the art, the specific meanings of the above terms in the present invention can be understood according to specific circumstances.
此外，术语“第一”、“第二”等仅用于描述目的，而不能理解为指示或暗示相对重要性或者隐含指明所指示的技术特征的数量。由此，限定有“第一”、“第二”的特征可以明示或者隐含地包括一个或者更多个该特征。Furthermore, the terms “first”, “second”, etc. are used for descriptive purposes only and cannot be understood as indicating or implying relative importance or implicitly indicating the quantity of indicated technical features. Therefore, features defined as "first" and "second" may explicitly or implicitly include one or more of these features.
癫痫是由于异常和过度的大脑神经元活动引起的慢性神经系统疾病，其中EEG信号是检测癫痫最常用和最有效的方法。癫痫患者通常对抗癫痫药物反应不佳，而且长期的服用药物会严重影响患者的身体，如果不及时服药很容易癫痫发作。手术切除癫痫病灶区是治疗癫痫比较有效的方法，但是对于癫痫区域比较大或位置不便于手术时该方法就遇到了困难。Epilepsy is a chronic neurological disease caused by abnormal and excessive brain neuron activity, in which EEG signals are the most commonly used and effective method for detecting epilepsy. Patients with epilepsy usually do not respond well to anti-epileptic drugs, and long-term use of drugs can seriously affect the patient's body. If the drug is not taken in time, epileptic seizures are likely to occur. Surgical removal of the epileptic focus area is a more effective method for treating epilepsy, but this method encounters difficulties when the epileptic area is large or the location is inconvenient for surgery.
本发明提供了一种可穿戴式癫痫监测设备，旨在能够在癫痫发作之前检测到脑电信号的变化，同时自动或手动的控制电极进行刺激，减少癫痫的发作，保护大脑。The invention provides a wearable epilepsy monitoring device, which is designed to detect changes in brain electrical signals before epileptic seizures, and at the same time automatically or manually control electrodes to stimulate, reduce epileptic seizures, and protect the brain.
本发明公开了一种可穿戴式癫痫监测设备，所述癫痫监测设备包括植入式电极装置1、固定盖2和穿戴装置3，所述植入式电极装置1用于固定在颅骨上，植入式电极装置1的设置位置是可先由医生判断并确定好癫痫病灶区，然后将植入式电极植入病灶区附近处的颅骨上，通过在颅骨上打孔的方式布置植入式电极装置。The invention discloses a wearable epilepsy monitoring device. The epilepsy monitoring device includes an implanted electrode device 1, a fixed cover 2 and a wearing device 3. The implanted electrode device 1 is used to be fixed on the skull. The position of the implantable electrode device 1 can be determined by the doctor first and determines the epilepsy focus area, and then the implantable electrode is implanted on the skull near the focus area, and the implantable electrode is arranged by drilling holes in the skull. device.
所述固定盖2设置在植入式电极装置1上，与植入式电极装置1连接，所述固定盖2内部设置有微处理器、电源、蓝牙模块、无线通讯装置和无线充电模块，该部分未在图中示出，但本领域技术人员通过本申请中的描述并结合本领域的知识能够知晓微处理器、电源、蓝牙模块、无线通讯装置和无线充电模块之间的连接方式以及与外部部件的连接方式。所述微处理器用于处理植入式电极装置1测量的数据(脑电信号)，然后通过无线通讯装置将所述数据发送到云端，并接收云端处理的结果，微处理器根据所述结果判断是否需要控制电极进行电刺激，同时微处理器通过蓝牙模块将所述结果发送到穿戴装置3，所述穿戴装置3提醒患者是否需要持续进行手动的脑刺激，所述穿戴装置3设置在患者的腕部。The fixed cover 2 is provided on the implantable electrode device 1 and is connected to the implantable electrode device 1. A microprocessor, a power supply, a Bluetooth module, a wireless communication device and a wireless charging module are provided inside the fixed cover 2. Some parts are not shown in the figure, but those skilled in the art can understand the connection methods and connections between the microprocessor, power supply, Bluetooth module, wireless communication device and wireless charging module through the description in this application and combined with the knowledge in the art. How external components are connected. The microprocessor is used to process the data (EEG signals) measured by the implanted electrode device 1, and then sends the data to the cloud through a wireless communication device, and receives the results of the cloud processing. The microprocessor makes a judgment based on the results. Whether it is necessary to control the electrodes for electrical stimulation, and at the same time, the microprocessor sends the results to the wearable device 3 through the Bluetooth module. The wearable device 3 reminds the patient whether he or she needs to continue manual brain stimulation. The wearable device 3 is set on the patient's head. wrist.
所述植入式电极装置1通过在颅骨上打孔的方式穿设在孔中，所打的孔为通孔，本发明安装一个植入式电极装置时只需要打一个孔，而不需要与现有技术一样在电极装置的周围打多个孔，本申请这样设计的好处在于减小了电极装置的设置的区域，不需要在周边打孔这样能够增加设置电极装置的个数能够更加精确的测量，具体的电极装置的结构如图1-5所示。所述植入式电极装置1中心处设置第一电极1.1，所述第一电极1.1上部设置有上支撑架 1.2，所述上支撑架1.2的端部设置有上夹持端1.4，所述上夹持端1.4的空腔内安装有上圆轴1.3，所述第一电极1.1的下部设置有下支撑架1.5，所述下支撑架1.5的端部设置下圆轴1.6，活动杆1.7的上部设置上滑槽1.8，下部设置下滑槽1.9，所述上滑槽1.8与上圆轴1.3配合，所述下滑槽1.9与下圆轴1.6配合，所述上滑槽1.8具有第一叉部1.12和第二叉部1.13，所述第二叉部1.13上端设置连接端1.14，所述活动杆1.7的下部设置下夹持端1.10，所述下夹持端1.10的下侧固定第二电极1.11，所述第一电极1.1和第二电极 1.11均通过连接线1.15与微处理器连接，所述连接端1.14上设置螺纹，与固定盖上的螺纹配合，固定盖2与连接端1.14旋转安装，固定盖2的侧边挤压连接端1.14，从而使第一叉部1.12越过上圆轴1.3，第二叉部1.13与上圆轴1.3抵靠，连接线1.15的长度设计满足在固定盖2能够旋转，即使连接线1.15有些绕转也不会影响，上夹持端1.4和下夹持端1.10上设置有防滑凸起。上夹持端1.4和下夹持端1.10分别夹在颅骨的上表面和下表面，可拆卸的连接防止二次伤害。根据图6-12所示的本发明装置的俯视图和固定盖2 安装的示意图，固定盖2安装是通过螺纹连接的方式，即旋转的方式将盖固定，在固定盖2旋转的过程中，不仅能够起到夹持的作用，同时还能够使连接线缠绕在装置上，起到收缩线的作用，只需一个固定盖就能够起到两个作用，使装置更加紧凑，利于安装。由于固定盖设计的不会旋转很多圈，或者更佳的设置是不超过一圈，因此连接线不会过多的旋转或缠绕，不会对连接线产生任何影响。在图12中植入式电极装置1的两侧为颅骨，示出了与颅骨的连接示意图。The implantable electrode device 1 is inserted into a hole by drilling a hole in the skull, and the hole is a through hole. When installing an implantable electrode device in the present invention, only one hole needs to be drilled, and no connection is required. In the prior art, multiple holes are drilled around the electrode device. The advantage of this design in this application is that it reduces the area where the electrode device is installed. There is no need to drill holes around the periphery. This can increase the number of electrode devices and make it more accurate. Measurement, the specific structure of the electrode device is shown in Figure 1-5. A first electrode 1.1 is provided at the center of the implantable electrode device 1. An upper support frame 1.2 is provided on the upper part of the first electrode 1.1. An upper clamping end 1.4 is provided at the end of the upper support frame 1.2. An upper circular shaft 1.3 is installed in the cavity of the clamping end 1.4, a lower support frame 1.5 is provided at the lower part of the first electrode 1.1, a lower circular shaft 1.6 is provided at the end of the lower support frame 1.5, and the upper part of the movable rod 1.7 An upper chute 1.8 is provided, and a lower chute 1.9 is provided at the bottom. The upper chute 1.8 cooperates with the upper circular shaft 1.3, and the lower chute 1.9 cooperates with the lower circular shaft 1.6. The upper chute 1.8 has a first fork 1.12 and The second fork part 1.13 is provided with a connecting end 1.14 at the upper end of the second fork part 1.13, and a lower clamping end 1.10 is set at the lower part of the movable rod 1.7. The second electrode 1.11 is fixed on the lower side of the lower clamping end 1.10, so The first electrode 1.1 and the second electrode 1.11 are both connected to the microprocessor through the connecting wire 1.15. The connecting end 1.14 is provided with threads to cooperate with the threads on the fixed cover. The fixed cover 2 and the connecting end 1.14 are rotated and installed. The fixed cover The side of 2 squeezes the connecting end 1.14, so that the first fork 1.12 crosses the upper circular shaft 1.3, and the second fork 1.13 abuts the upper circular shaft 1.3. The length of the connecting line 1.15 is designed to ensure that the fixed cover 2 can rotate. Even if the connecting wire 1.15 is somewhat twisted, it will not be affected. The upper clamping end 1.4 and the lower clamping end 1.10 are provided with anti-slip protrusions. The upper clamping end 1.4 and the lower clamping end 1.10 are respectively clamped on the upper and lower surfaces of the skull, and the detachable connection prevents secondary injuries. According to the top view of the device of the present invention and the schematic diagram of the installation of the fixed cover 2 shown in Figures 6-12, the fixed cover 2 is installed through a threaded connection, that is, the cover is fixed in a rotating manner. During the rotation of the fixed cover 2, not only It can play a clamping role, and at the same time, it can wrap the connecting wire around the device and act as a shrinking wire. Only one fixed cover can play two roles, making the device more compact and easier to install. Since the fixed cover is designed not to rotate many times, or better yet, no more than one turn, the cable will not be rotated or twisted too much and will not have any impact on the cable. In Figure 12, the two sides of the implantable electrode device 1 are skulls, showing a schematic diagram of the connection with the skulls.
如图13-16，所述穿戴装置3具有外壳3.1，所述外壳3.1上设置第一显示屏3.2和第二显示屏3.3，在显示屏的周围设置提示灯3.4，在提示灯3.4 的外侧设置与各提示灯3.4对应的按钮3.5，所述提示灯3.4设置有多个，并相应的表示多个不同的时间等级，按压按钮3.5表示选择相应的刺激时间，外壳3.1的侧面设置旋钮3.6，所述旋钮3.6用于调节电刺激的强度和频率，并将强度和频率分别通过第一显示屏3.2和第二显示屏3.3显示，在与旋钮3.6相对的外壳3.1的另一侧上设置喇叭3.7，所述外壳3.1的背面设置震动头3.8。当微处理器接收到的云端的处理结果是需要进行电刺激，穿戴装置3 通过提示灯3.4闪烁、喇叭3.7发出提示音和震动头3.8震动的方式告知癫痫患者。同时患者可以通过按钮3.5选择刺激时间，通过旋钮3.6调节电刺激的强度，第一显示屏3.2显示当前的强度等级，将旋钮3.6向外拔出小段距离调节电刺激的频率，第二显示屏3显示当前的刺激频率。As shown in Figures 13-16, the wearable device 3 has a shell 3.1. A first display screen 3.2 and a second display screen 3.3 are provided on the shell 3.1. A prompt light 3.4 is provided around the display screen, and a prompt light 3.4 is provided outside the prompt light 3.4. There are buttons 3.5 corresponding to each prompt light 3.4. There are multiple prompt lights 3.4 and correspondingly represent multiple different time levels. Pressing the button 3.5 represents selecting the corresponding stimulation time. A knob 3.6 is provided on the side of the housing 3.1, so The knob 3.6 is used to adjust the intensity and frequency of electrical stimulation, and the intensity and frequency are displayed through the first display screen 3.2 and the second display screen 3.3 respectively. A speaker 3.7 is provided on the other side of the housing 3.1 opposite to the knob 3.6. A vibrating head 3.8 is provided on the back of the housing 3.1. When the microprocessor receives the cloud processing result that electrical stimulation is required, the wearable device 3 notifies the epilepsy patient by flashing the prompt light 3.4, emitting a prompt tone from the speaker 3.7, and vibrating the vibrating head 3.8. At the same time, the patient can select the stimulation time through button 3.5 and adjust the intensity of electrical stimulation through knob 3.6. The first display screen 3.2 displays the current intensity level. Pull the knob 3.6 out a short distance to adjust the frequency of electrical stimulation. The second display screen 3 Displays the current stimulation frequency.
所述植入式电极装置的微处理器进行如下处理：The microprocessor of the implantable electrode device performs the following processing:
首先，利用四层小波变换结合三阶Daubechies小波函数对其去噪重构；First, use four-layer wavelet transform combined with the third-order Daubechies wavelet function to denoise and reconstruct it;
其次，对去噪重构后的脑电信号进行互补集合经验模态分解CEEMD(complementary ensemble empirical mode decomposition(CEEMD))，将脑电信号分解为本征模态分量IMF(intrinsic mode function，IMF)，并且提取包含大部分脑电信号能量的第三和第四IMF分量将其作为主要的IMF；Secondly, perform complementary ensemble empirical mode decomposition (CEEMD) on the denoised and reconstructed EEG signal to decompose the EEG signal into intrinsic mode components IMF (intrinsic mode function, IMF). , and extract the third and fourth IMF components that contain most of the EEG signal energy as the main IMF;
接着，对这两个主要的IMF分量进行相空间重构，其中保留与脑电系统动态相关联的属性，对这两个主要的IMF分量进行相空间重构后计算欧几里德距离ED，用于推导特征，所述特征信号证明了癫痫患者癫痫先兆期的脑电信号模式与其他状态脑电信号模式(癫痫发作间期、癫痫发作期)存在显着差异；Then, the phase space of the two main IMF components is reconstructed, which retains the properties associated with the dynamics of the EEG system. The Euclidean distance ED is calculated after the phase space reconstruction of the two main IMF components. Used to derive features, the characteristic signal proves that there is a significant difference between the EEG signal pattern of epilepsy patients in the epilepsy aura stage and the EEG signal pattern of other states (epileptic interictal period, epileptic seizure period);
然后，将推导得到的特征信号通过固定盖2的无线通讯装置发送到云端，作为RBF神经网络的输入信号，并利用神经网络构建一组动态估计器，计算输入信号与云端存储的数据库中脑电信号模式(包括了癫痫发作先兆期信号、癫痫发作间期信号和癫痫发作期信号)之间的差异；Then, the derived characteristic signal is sent to the cloud through the wireless communication device of the fixed cover 2 as the input signal of the RBF neural network, and a set of dynamic estimators are constructed using the neural network to calculate the input signal and the EEG in the database stored in the cloud. Differences between signal patterns (including epileptic seizure precursor signals, interictal signals and epileptic seizure signals);
若输入信号与数据库中的癫痫发作先兆期信号差异最小，则该输入信号判断为癫痫发作先兆期信号；若输入信号与数据库中的癫痫发作间期信号差异最小，则该输入信号判断为癫痫发作间期信号；若输入信号与数据库中的癫痫发作期信号差异最小，则该输入信号判断为癫痫发作期信号；If the difference between the input signal and the epileptic seizure precursor phase signal in the database is the smallest, the input signal is judged to be the epileptic seizure precursor phase signal; if the input signal has the smallest difference to the epileptic seizure interictal signal in the database, the input signal is judged to be an epileptic seizure. Interval signal; if the difference between the input signal and the epileptic seizure signal in the database is minimal, the input signal is judged to be the epileptic seizure signal;
对于判断为癫痫发作先兆期的信号，云端将该判断结果发送回固定盖2 内部的微处理器，进行脑刺激。For signals judged to be in the premonitory stage of epileptic seizures, the cloud sends the judgment results back to the microprocessor inside the fixed cover 2 for brain stimulation.
所述上支撑架1.2、下支撑架1.5和活动杆1.7环绕第一电极1.1均匀设置有多个。A plurality of upper support frames 1.2, lower support frames 1.5 and movable rods 1.7 are evenly arranged around the first electrode 1.1.
所述下夹持端1.10为弹性体，在将植入式电极装置1插入到颅骨开设的孔中时，下夹持端1.10可被压缩产生形变，在插入之后恢复，并且在夹持时是柔性夹持，既不会伤害颅骨，也能够较好的夹持。The lower clamping end 1.10 is an elastomer. When the implantable electrode device 1 is inserted into the hole opened in the skull, the lower clamping end 1.10 can be compressed to deform, recover after insertion, and be Flexible clamping will not damage the skull and can be clamped well.
与现有技术相比，本发明具有以下有益效果：本发明安装方便，减少患者的手术痛苦；在需要更换时能够比较快速的取下，对患者的脑部伤害较小；本发明控制方便，能够在癫痫发作前提醒患者或自动进行脑部刺激，达到控制癫痫不发作，减少癫痫发作的次数，保护大脑。Compared with the prior art, the present invention has the following beneficial effects: the present invention is easy to install and reduces the patient's surgical pain; it can be removed relatively quickly when replacement is needed, causing less damage to the patient's brain; the present invention is easy to control, It can remind patients before epileptic seizures or automatically perform brain stimulation to control epilepsy, reduce the number of epileptic seizures, and protect the brain.
| Application Number | Priority Date | Filing Date | Title |
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| CN201911387103.7ACN111134665B (en) | 2019-12-30 | 2019-12-30 | A wearable epilepsy monitoring device |
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201911387103.7ACN111134665B (en) | 2019-12-30 | 2019-12-30 | A wearable epilepsy monitoring device |
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| CN201911387103.7AActiveCN111134665B (en) | 2019-12-30 | 2019-12-30 | A wearable epilepsy monitoring device |
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