CN111134665A - Wearable epilepsy monitoring facilities - Google Patents

Abstract

Translated fromChinese

本发明公开了一种可穿戴式癫痫监测设备，癫痫监测设备包括植入式电极装置、固定盖和穿戴装置，植入式电极装置用于固定在颅骨上，固定盖设置在植入式电极装置上，与植入式电极装置连接，固定盖内部设置有微处理器、电源、蓝牙模块和无线充电模块，微处理器用于处理植入式电极装置测量的数据，并通过蓝牙模块发送到穿戴装置，穿戴装置设置在患者的腕部。与现有技术相比，本发明安装方便，减少患者的手术痛苦；在需要更换时能够比较快速的取下，对患者的脑部伤害较小；本发明控制方便，能够在癫痫发作前提醒患者或自动进行脑部刺激，达到控制癫痫不发作，减少癫痫发作的次数。

The invention discloses a wearable epilepsy monitoring device. The epilepsy monitoring device comprises an implanted electrode device, a fixed cover and a wearable device. The implanted electrode device is used to be fixed on the skull, and the fixed cover is arranged on the implanted electrode device. connected to the implantable electrode device, the fixed cover is provided with a microprocessor, a power supply, a Bluetooth module and a wireless charging module. The microprocessor is used to process the data measured by the implantable electrode device and send it to the wearable device through the Bluetooth module. , the wearable device is set on the patient's wrist. Compared with the prior art, the present invention is easy to install, reducing the pain of the patient's operation; when it needs to be replaced, it can be removed relatively quickly, and the brain damage to the patient is less; the present invention is easy to control, and can remind the patient before epileptic seizures. Or automatically perform brain stimulation to control epilepsy without seizures and reduce the number of seizures.

Description

Wearable epilepsy monitoring facilities

Technical Field

The invention belongs to the field of medical instruments, and particularly relates to wearable epilepsy monitoring equipment.

Background

Epilepsy is a chronic neurological disease due to abnormal and excessive cerebral neuronal activity, with EEG signals being the most common and effective method for detecting epilepsy.

Epileptic patients often have poor response to antiepileptic drugs, and long-term administration of drugs can seriously affect the body of the patient, and if the drugs are not taken in time, the epileptic seizures are easy to occur. Surgical removal of the focal area of epilepsy is a more effective method of treating epilepsy, but it has difficulties when the area of epilepsy is large or the location is inconvenient for surgery.

Therefore, there is a need for a device that can timely remind the patient to avoid or reduce epileptic seizures by way of electrical stimulation, either manually or automatically.

Disclosure of Invention

In view of the above technical problems, the present invention provides a wearable epilepsy monitoring device, which is intended to detect the change of electroencephalogram signals before a seizure, and at the same time, automatically or manually control electrodes to stimulate, reduce the seizure and protect the brain.

In order to solve the technical problems, the technical scheme of the invention is as follows:

a wearable epilepsy monitoring device comprises an implantedelectrode device 1, afixed cover 2 and a wearable device 3, wherein the implantedelectrode device 1 is used for being fixed on a skull at an epilepsy focus determined in advance, thefixed cover 2 is arranged on the implantedelectrode device 1 and connected with the implantedelectrode device 1, a microprocessor, a power supply, a Bluetooth module, a wireless communication device and a wireless charging module are arranged inside thefixed cover 2, the microprocessor is used for processing data measured by the implantedelectrode device 1, then sending the data to the cloud end through the wireless communication device and receiving the result processed by the cloud end, the microprocessor judges whether to control an electrode to carry out electrical stimulation according to the result, meanwhile, the microprocessor sends the result to the wearable device 3 through the Bluetooth module, and the wearable device 3 reminds a patient whether to continuously carry out manual brain stimulation, the wearing device 3 is provided at the wrist of the patient.

Further, a first electrode 1.1 is arranged at the center of the implantedelectrode device 1, an upper support frame 1.2 is arranged at the upper part of the first electrode 1.1, an upper clamping end 1.4 is arranged at the end part of the upper support frame 1.2, an upper circular shaft 1.3 is arranged in a cavity of the upper clamping end 1.4, a lower support frame 1.5 is arranged at the lower part of the first electrode 1.1, a lower circular shaft 1.6 is arranged at the end part of the lower support frame 1.5, an upper sliding chute 1.8 is arranged at the upper part of the movable rod 1.7, a lower sliding chute 1.9 is arranged at the lower part, the upper sliding chute 1.8 is matched with the upper circular shaft 1.3, the lower sliding chute 1.9 is matched with the lower circular shaft 1.6, the upper sliding chute 1.8 is provided with a first fork part 1.12 and a second fork part 1.13, a connecting end 1.14 is arranged at the upper end of the second fork part 1.13, a lower clamping end 1.10 is arranged at the side surface of the lower part of the movable rod 1.7, a second electrode 1.11 and a second electrode 1.11 are connected with a microprocessor through a second clamping end 1.11, the connecting end 1.14 is provided with threads which are matched with the threads on the fixing cover, and the upper clamping end 1.4 and the lower clamping end 1.10 are provided with anti-skid protrusions.

Further, the wearable device 3 is provided with a shell 3.1, a first display screen 3.2 and a second display screen 3.3 are arranged on the shell 3.1, a prompt lamp 3.4 is arranged around the display screen, a button 3.5 corresponding to each prompt lamp 3.4 is arranged on the outer side of each prompt lamp 3.4, a plurality of prompt lamps 3.4 are arranged and correspondingly represent a plurality of different time levels, the button 3.5 is pressed to represent that corresponding stimulation time is selected, a knob 3.6 is arranged on the side face of the shell 3.1, the knob 3.6 is used for adjusting the intensity and frequency of electric stimulation, the intensity and frequency are respectively displayed through the first display screen 3.2 and the second display screen 3.3, a loudspeaker 3.7 is arranged on the other side of the shell 3.1 opposite to the knob 3.6, and a vibration head 3.8 is arranged on the back face of the shell 3.1.

Further, the implantedelectrode device 1 acquires the electroencephalogram signals at the epileptic focus and then sends the acquired electroencephalogram signals to the microprocessor inside thefixed cover 2, and the microprocessor performs the following processing:

firstly, denoising and reconstructing the three-order Daubechies wavelet function by utilizing four-layer wavelet transform;

secondly, performing complementary set empirical mode decomposition (CEEMD) on the de-noised and reconstructed electroencephalogram signals, decomposing the electroencephalogram signals into intrinsic mode components (IMFs), and extracting third and fourth IMF components containing most electroencephalogram signal energy to serve as main IMFs;

then, carrying out phase space reconstruction on the two main IMF components, calculating Euclidean distance ED after carrying out phase space reconstruction on the two main IMF components, and deriving features, wherein the feature signals prove that the EEG signal mode of the epileptic precursor phase of the epileptic patient is obviously different from the EEG signal modes of other states;

then, the derived characteristic signals are sent to the cloud end through a wireless communication device of thefixed cover 2 to serve as input signals of the RBF neural network, a group of dynamic estimators are constructed by the neural network, and the difference between the input signals and brain electrical signal modes in a database stored in the cloud end is calculated;

if the difference between the input signal and the preempt period signal in the database is minimum, the input signal is judged to be the preempt period signal; if the difference between the input signal and the epileptic seizure interval signal in the database is minimum, the input signal is judged as the epileptic seizure interval signal; if the difference between the input signal and the epileptic seizure phase signal in the database is minimum, the input signal is judged to be the epileptic seizure phase signal;

and for the signal which is judged to be in the preempt period of the epileptic seizure, the cloud sends the judgment result back to the microprocessor in thefixed cover 2 for brain stimulation.

Further, the other states are inter-seizure and seizure phases, and the brain electrical signal pattern includes pre-seizure signals, inter-seizure signals and intra-seizure signals.

Further, the wearing device 3 informs the epileptic through the modes of the prompting lamp 3.4 flickering, the loudspeaker 3.7 giving out the prompting sound and the vibrating head 3.8 vibrating.

Furthermore, a plurality of upper support frames 1.2, lower support frames 1.5 and movable rods 1.7 are uniformly arranged around the first electrode 1.1; preferably 4-12.

Further, the lower clamping end 1.10 is an elastic body, and when theimplantable electrode device 1 is inserted into a hole formed in the skull, the lower clamping end 1.10 can be compressed to generate deformation, and can recover after being inserted, and is a flexible clamping when being clamped.

Compared with the prior art, the invention has the following beneficial effects: the invention has convenient installation and reduces the operation pain of patients; the device can be taken down quickly when needing to be replaced, and has little harm to the brain of a patient; the invention is convenient to control, can wake a patient or automatically stimulate the brain before the epileptic seizure, achieves the aims of controlling the epileptic seizure without seizures, reducing the times of the epileptic seizure and protecting the brain.

Drawings

FIG. 1 is a first schematic view of an implantable electrode device according to the present invention;

FIG. 2 is a second schematic structural view of an implantable electrode assembly of the present invention;

FIG. 3 is a third schematic view of an implantable electrode assembly of the present invention;

FIG. 4 is a schematic view of the movable rod structure of the present invention;

FIG. 5 is a schematic view of the support device of the present invention;

FIG. 6 is a first top view of an implantable electrode device in accordance with the present invention;

FIG. 7 is a second top view of the implantable electrode device of the present invention;

FIG. 8 is a schematic view of an implantable electrode assembly with a retaining cap according to the present invention;

FIG. 9 is a cross-sectional view of an implantable electrode assembly with a retaining cap in accordance with the present invention;

FIG. 10 is a schematic diagram of a movable rod rotation structure of the implantable electrode assembly of the present invention;

FIG. 11 is a cross-sectional view of a movable rod of an implantable electrode assembly of the present invention in rotation;

FIG. 12 is a schematic view of an implantable electrode assembly of the present invention clamped to the skull;

FIG. 13 is a front view of the wearable device of the present invention;

FIG. 14 is a schematic view of the right side of the inventive wearing device;

FIG. 15 is a schematic view of the left side of the wearing device of the present invention;

FIG. 16 is a rear side view of the wearable device of the present invention;

in the figure, an implantedelectrode device 1, a first electrode 1.1, an upper support frame 1.2, an upper round shaft 1.3, an upper clamping end 1.4, a lower support frame 1.5, a lower round shaft 1.6, a movable rod 1.7, an upper chute 1.8, a lower chute 1.9, a lower clamping end 1.10, a second electrode 1.11, a first fork part 1.12, a second fork part 1.13, a connecting end 1.14, a connecting wire 1.15, afixed cover 2, a wearing device 3, a housing 3.1, a first display screen 3.2, a second display screen 3.3, a prompting lamp 3.4, a button 3.5, a knob 3.6, a horn 3.7 and a vibration head 3.8 are arranged.

Detailed Description

The technical solutions in the embodiments of the present invention will be clearly and completely described below with reference to the drawings in the embodiments of the present invention, and it is obvious that the described embodiments are only a part of the embodiments of the present invention, and not all of the embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.

In the description of the present invention, it is to be understood that the terms "center", "length", "width", "thickness", "upper", "lower", "front", "rear", "left", "right", "vertical", "horizontal", "top", "bottom", "inner", "outer", "axial", "circumferential", and the like, indicate orientations or positional relationships based on those shown in the drawings, and are used merely for convenience of description and for simplicity of description, and do not indicate or imply that the device or element being referred to must have a particular orientation, be constructed and operated in a particular orientation, and thus, are not to be considered as limiting the present invention.

In the present invention, unless otherwise expressly specified or limited, the terms "disposed," "mounted," "connected," and "fixed" are to be construed broadly and may, for example, be fixedly connected or detachably connected; may be a mechanical connection; may be directly connected or indirectly connected through an intermediate. The specific meanings of the above terms in the present invention can be understood by those skilled in the art according to specific situations.

Furthermore, the terms "first", "second", etc. are used for descriptive purposes only and are not to be construed as indicating or implying relative importance or implicitly indicating the number of technical features indicated. Thus, a feature defined as "first" or "second" may explicitly or implicitly include one or more of that feature.

Epilepsy is a chronic neurological disease due to abnormal and excessive cerebral neuronal activity, with EEG signals being the most common and effective method for detecting epilepsy. Epileptic patients often have poor response to antiepileptic drugs, and long-term administration of drugs can seriously affect the body of the patient, and if the drugs are not taken in time, the epileptic seizures are easy to occur. Surgical removal of the focal area of epilepsy is a more effective method of treating epilepsy, but it has difficulties when the area of epilepsy is large or the location is inconvenient for surgery.

The invention provides wearable epilepsy monitoring equipment, which aims to detect the change of an electroencephalogram signal before an epileptic seizure, and simultaneously automatically or manually control an electrode to stimulate, reduce the epileptic seizure and protect the brain.

The invention discloses wearable epilepsy monitoring equipment, which comprises animplantable electrode device 1, afixed cover 2 and a wearing device 3, wherein theimplantable electrode device 1 is fixed on a skull, the setting position of theimplantable electrode device 1 can be judged and determined by a doctor, then an implantable electrode is implanted on the skull near a focal region, and the implantable electrode device is arranged in a manner of punching on the skull.

Thefixed cover 2 is disposed on theimplantable electrode device 1 and connected to theimplantable electrode device 1, and a microprocessor, a power supply, a bluetooth module, a wireless communication device and a wireless charging module are disposed inside thefixed cover 2, which are not shown in the drawings, but those skilled in the art can know the connection mode among the microprocessor, the power supply, the bluetooth module, the wireless communication device and the wireless charging module and the connection mode with external components through the description in the present application and the knowledge in the art. The microprocessor is used for processing data (electroencephalogram signals) measured by the implantedelectrode device 1, then sending the data to the cloud end through the wireless communication device, receiving results processed by the cloud end, judging whether the electrodes need to be controlled to perform electrical stimulation according to the results by the microprocessor, sending the results to the wearable device 3 through the Bluetooth module by the microprocessor, reminding the patient whether the patient needs to continuously perform manual brain stimulation through the wearable device 3, and setting the wearable device 3 on the wrist of the patient.

The implantedelectrode device 1 is arranged in the hole in a penetrating mode through punching on the skull, the punched hole is a through hole, only one hole needs to be punched when one implanted electrode device is installed, and a plurality of holes do not need to be punched around the electrode device like the prior art, the implanted electrode device has the advantages that the arrangement area of the electrode device is reduced, the number of the arranged electrode devices can be increased without punching on the periphery, the more accurate measurement can be realized, and the specific structure of the electrode device is shown in figures 1-5. A first electrode 1.1 is arranged at the center of the implantedelectrode device 1, an upper support frame 1.2 is arranged at the upper part of the first electrode 1.1, an upper clamping end 1.4 is arranged at the end part of the upper support frame 1.2, an upper round shaft 1.3 is arranged in a cavity of the upper clamping end 1.4, a lower support frame 1.5 is arranged at the lower part of the first electrode 1.1, a lower round shaft 1.6 is arranged at the end part of the lower support frame 1.5, an upper sliding chute 1.8 is arranged at the upper part of the movable rod 1.7, a lower sliding chute 1.9 is arranged at the lower part of the movable rod 1.8, the upper sliding chute 1.8 is matched with the upper round shaft 1.3, the lower sliding chute 1.9 is matched with the lower round shaft 1.6, the upper sliding chute 1.8 is provided with a first fork part 1.12 and a second fork part 1.13, a connecting end 1.14 is arranged at the upper end of the second fork part 1.13, a lower clamping end 1.7 is provided with a lower clamping end 1.10, a second electrode 1.11 is fixed at the lower side of the lower clamping end 1.10, and thefirst electrode 1, set up the screw thread on the link 1.14, with the fixed screw-thread fit who covers, fixedlid 2 and the rotatory installation of link 1.14, the side extrusion link 1.14 offixed lid 2, thereby make first fork portion 1.12 cross last round axle 1.3, second fork portion 1.13 supports with last round axle 1.3 and leans on, the length design of connecting wire 1.15 satisfies and can rotate atfixed lid 2, even connecting wire 1.15 revolutes for a bit and does not influence yet, be provided with the non-skid protrusion on last exposed core 1.4 and the lower exposed core 1.10. The upper clamping end 1.4 and the lower clamping end 1.10 are clamped on the upper surface and the lower surface of the skull respectively, and the detachable connection prevents secondary injury. According to the plan view of the device and the schematic view of the installation of thefixed cover 2 shown in fig. 6-12, thefixed cover 2 is installed by fixing the cover in a threaded connection mode, namely a rotation mode, in the rotation process of thefixed cover 2, not only can the clamping function be achieved, but also the connecting wire can be wound on the device to achieve the effect of shrinking the wire, only one fixed cover can achieve two effects, the device is more compact, and the installation is facilitated. Because the design of the fixed cover can not rotate for many turns or better setting is not more than one turn, the connecting wire can not rotate or wind too much and can not have any influence on the connecting wire. In fig. 12, the implantedelectrode device 1 is flanked by the skull bone, and a schematic view of the connection to the skull bone is shown.

As shown in fig. 13-16, the wearable device 3 has a housing 3.1, a first display 3.2 and a second display 3.3 are disposed on the housing 3.1, a plurality of indicator lights 3.4 are disposed around the display, a button 3.5 corresponding to each indicator light 3.4 is disposed outside the indicator lights 3.4, the indicator lights 3.4 are disposed in plurality and correspondingly represent a plurality of different time levels, pressing the button 3.5 represents selecting a corresponding stimulation time, a knob 3.6 is disposed on a side surface of the housing 3.1, the knob 3.6 is used for adjusting intensity and frequency of electrical stimulation, the intensity and frequency are respectively displayed through the first display 3.2 and the second display 3.3, a speaker 3.7 is disposed on the other side of the housing 3.1 opposite to the knob 3.6, and a vibrating head 3.8 is disposed on a back surface of the housing 3.1. When the processing result of the cloud received by the microprocessor is that electrical stimulation is needed, the wearable device 3 informs the epileptic patient in a mode of flashing the prompting lamp 3.4 and giving out a prompting sound through the loudspeaker 3.7 and vibrating the vibrating head 3.8. Meanwhile, the patient can select the stimulation time through the button 3.5, the intensity of the electrical stimulation is adjusted through the knob 3.6, the first display screen 3.2 displays the current intensity level, the knob 3.6 is pulled out for a short distance to adjust the frequency of the electrical stimulation, and the second display screen 3 displays the current stimulation frequency.

The microprocessor of the implanted electrode device performs the following processing:

firstly, denoising and reconstructing the three-order Daubechies wavelet function by utilizing four-layer wavelet transform;

secondly, performing Complementary Ensemble Empirical Mode Decomposition (CEEMD) on the de-noised and reconstructed electroencephalogram signal, decomposing the electroencephalogram signal into intrinsic mode components (IMFs), and extracting third and fourth IMF components containing most electroencephalogram signal energy to serve as main IMFs;

then, performing phase space reconstruction on the two main IMF components, wherein the attribute associated with the brain electrical system dynamic state is reserved, and calculating the Euclidean distance ED after performing phase space reconstruction on the two main IMF components for deriving a characteristic signal, wherein the characteristic signal proves that the brain electrical signal pattern of the epileptic precursor stage of the epileptic patient has a significant difference with the brain electrical signal patterns of other states (inter-epileptic seizure and epileptic seizure stage);

then, the derived characteristic signals are sent to the cloud end through a wireless communication device of the fixedcover 2 to serve as input signals of an RBF neural network, a group of dynamic estimators are constructed by the neural network, and the difference between the input signals and brain electrical signal modes (including preeclampsia signals, interphase epileptic seizure signals and epileptic seizure signals) in a database stored in the cloud end is calculated;

if the difference between the input signal and the preempt period signal in the database is minimum, the input signal is judged to be the preempt period signal; if the difference between the input signal and the epileptic seizure interval signal in the database is minimum, the input signal is judged as the epileptic seizure interval signal; if the difference between the input signal and the epileptic seizure phase signal in the database is minimum, the input signal is judged to be the epileptic seizure phase signal;

and for the signal which is judged to be in the preempt period of the epileptic seizure, the cloud sends the judgment result back to the microprocessor in the fixedcover 2 for brain stimulation.

A plurality of upper support frames 1.2, lower support frames 1.5 and movable rods 1.7 are uniformly arranged around the first electrode 1.1.

The lower clamping end 1.10 is an elastic body, when theimplantable electrode device 1 is inserted into a hole formed in a skull, the lower clamping end 1.10 can be compressed to generate deformation and recover after insertion, and is flexibly clamped during clamping, so that the skull is not damaged, and the electrode device can be better clamped.

Compared with the prior art, the invention has the following beneficial effects: the invention has convenient installation and reduces the operation pain of patients; the device can be taken down quickly when needing to be replaced, and has little harm to the brain of a patient; the invention is convenient to control, can wake a patient or automatically stimulate the brain before the epileptic seizure, achieves the aims of controlling the epileptic seizure without seizures, reducing the times of the epileptic seizure and protecting the brain.

Claims (8)

Translated fromChinese

1.一种可穿戴式癫痫监测设备，所述癫痫监测设备包括植入式电极装置(1)、固定盖(2)和穿戴装置(3)，其特征在于：1. A wearable epilepsy monitoring device, the epilepsy monitoring device comprising an implantable electrode device (1), a fixed cover (2) and a wearable device (3), characterized in that:所述植入式电极装置(1)用于固定在事先已经确定的癫痫病灶区处的颅骨上，所述固定盖(2)设置在植入式电极装置(1)上，与植入式电极装置(1)连接，所述固定盖(2)内部设置有微处理器、电源、蓝牙模块、无线通讯装置和无线充电模块，所述微处理器用于处理植入式电极装置(1)测量的数据，然后通过无线通讯装置将所述数据发送到云端，并接收云端处理的结果，微处理器根据所述结果判断是否需要控制电极进行电刺激，同时微处理器通过蓝牙模块将所述结果发送到穿戴装置(3)，所述穿戴装置(3)提醒患者是否需要持续进行手动的脑刺激，所述穿戴装置(3)设置在患者的腕部。The implantable electrode device (1) is used to be fixed on the skull at a pre-determined epilepsy focus area, and the fixation cover (2) is arranged on the implantable electrode device (1), and is connected to the implantable electrode. The device (1) is connected, and the fixed cover (2) is internally provided with a microprocessor, a power supply, a Bluetooth module, a wireless communication device and a wireless charging module, and the microprocessor is used for processing the data measured by the implantable electrode device (1). data, and then send the data to the cloud through the wireless communication device, and receive the result of the cloud processing, the microprocessor judges whether it is necessary to control the electrodes for electrical stimulation according to the result, and the microprocessor sends the result through the Bluetooth module. To the wearing device (3), the wearing device (3) reminds the patient whether continuous manual brain stimulation is required, and the wearing device (3) is arranged on the patient's wrist.2.如权利要求1所述的一种可穿戴式癫痫监测设备，其特征在于：所述植入式电极装置(1)中心处设置第一电极(1.1)，所述第一电极(1.1)上部设置有上支撑架(1.2)，所述上支撑架(1.2)的端部设置有上夹持端(1.4)，所述上夹持端(1.4)的空腔内安装有上圆轴(1.3)，所述第一电极(1.1)的下部设置有下支撑架(1.5)，所述下支撑架(1.5)的端部设置下圆轴(1.6)，活动杆(1.7)的上部设置上滑槽(1.8)，下部设置下滑槽(1.9)，所述上滑槽(1.8)与上圆轴(1.3)配合，所述下滑槽(1.9)与下圆轴(1.6)配合，所述上滑槽(1.8)具有第一叉部(1.12)和第二叉部(1.13)，所述第二叉部(1.13)上端设置连接端(1.14)，所述活动杆(1.7)的下部侧面设置下夹持端(1.10)，所述活动杆(1.7)的下端固定第二电极(1.11)，所述第一电极(1.1)和第二电极(1.11)均通过连接线(1.15)与微处理器连接，所述连接端(1.14)上设置螺纹，与固定盖上的螺纹配合，上夹持端(1.4)和下夹持端(1.10)上设置有防滑凸起。2. A wearable epilepsy monitoring device according to claim 1, characterized in that: a first electrode (1.1) is provided at the center of the implantable electrode device (1), and the first electrode (1.1) The upper part is provided with an upper support frame (1.2), the end of the upper support frame (1.2) is provided with an upper clamping end (1.4), and an upper circular shaft (1.4) is installed in the cavity of the upper clamping end (1.4). 1.3), the lower part of the first electrode (1.1) is provided with a lower support frame (1.5), the end of the lower support frame (1.5) is provided with a lower circular shaft (1.6), and the upper part of the movable rod (1.7) is provided with an upper A chute (1.8), a lower chute (1.9) is arranged at the lower part, the upper chute (1.8) is matched with the upper round shaft (1.3), the lower chute (1.9) is matched with the lower round shaft (1.6), the upper The chute (1.8) has a first fork (1.12) and a second fork (1.13), the upper end of the second fork (1.13) is provided with a connecting end (1.14), and the lower side of the movable rod (1.7) is provided with The lower clamping end (1.10), the lower end of the movable rod (1.7) is fixed with the second electrode (1.11), the first electrode (1.1) and the second electrode (1.11) are connected with the microprocessing through the connecting line (1.15) The connecting end (1.14) is provided with threads to cooperate with the threads on the fixed cover, and the upper clamping end (1.4) and the lower clamping end (1.10) are provided with anti-skid protrusions.3.如权利要求2所述的一种可穿戴式癫痫监测设备，其特征在于：所述穿戴装置(3)具有外壳(3.1)，所述外壳(3.1)上设置第一显示屏(3.2)和第二显示屏(3.3)，在显示屏的周围设置提示灯(3.4)，在提示灯(3.4)的外侧设置与各提示灯(3.4)对应的按钮(3.5)，所述提示灯(3.4)设置有多个，并相应的表示多个不同的时间等级，按压按钮(3.5)表示选择相应的刺激时间，外壳(3.1)的侧面设置旋钮(3.6)，所述旋钮(3.6)用于调节电刺激的强度和频率，并将强度和频率分别通过第一显示屏(3.2)和第二显示屏(3.3)显示，在与旋钮(3.6)相对的外壳(3.1)的另一侧上设置喇叭(3.7)，所述外壳(3.1)的背面设置震动头(3.8)。3. The wearable epilepsy monitoring device according to claim 2, wherein the wearable device (3) has a casing (3.1), and a first display screen (3.2) is provided on the casing (3.1). and the second display screen (3.3), a prompt light (3.4) is arranged around the display screen, and buttons (3.5) corresponding to each prompt light (3.4) are arranged outside the prompt light (3.4). ) are provided with multiple, and correspondingly represent multiple different time levels, press the button (3.5) to select the corresponding stimulation time, the side of the housing (3.1) is provided with a knob (3.6), the knob (3.6) is used to adjust The intensity and frequency of the electrical stimulation are displayed through the first display screen (3.2) and the second display screen (3.3) respectively, and a horn is provided on the other side of the housing (3.1) opposite the knob (3.6) (3.7), a vibrating head (3.8) is arranged on the back of the casing (3.1).4.如权利要求3所述的一种可穿戴式癫痫监测设备，其特征在于：4. a kind of wearable epilepsy monitoring equipment as claimed in claim 3, is characterized in that:所述植入式电极装置(1)获取癫痫病灶区处的脑电信号后发送到固定盖(2)内部的微处理器上，微处理器进行如下处理：The implanted electrode device (1) acquires the EEG signal at the epilepsy focus area and sends it to the microprocessor inside the fixed cover (2), and the microprocessor performs the following processing:首先，利用四层小波变换结合三阶Daubechies小波函数对其去噪重构；First, use the four-layer wavelet transform combined with the third-order Daubechies wavelet function to denoise and reconstruct it;其次，对去噪重构后的脑电信号进行互补集合经验模态分解CEEMD，将脑电信号分解为本征模态分量IMF，并且提取包含大部分脑电信号能量的第三和第四IMF分量将其作为主要的IMF；Secondly, perform complementary ensemble empirical mode decomposition (CEEMD) on the denoised and reconstructed EEG signals, decompose the EEG signals into eigenmode component IMFs, and extract the third and fourth IMFs containing most of the EEG signal energy. The component uses it as the main IMF;接着，对这两个主要的IMF分量进行相空间重构，对这两个主要的IMF分量进行相空间重构后计算欧几里德距离ED，用于推导特征，所述特征信号证明了癫痫患者癫痫先兆期的脑电信号模式与其他状态脑电信号模式存在显着差异；Next, the two main IMF components are reconstructed in phase space, and the Euclidean distance ED is calculated after the phase space reconstruction of these two main IMF components, which is used to derive features, and the feature signals prove that epilepsy There are significant differences between the EEG signal patterns in patients with aura of epilepsy and other states;然后，将推导得到的特征信号通过固定盖(2)的无线通讯装置发送到云端，作为RBF神经网络的输入信号，并利用神经网络构建一组动态估计器，计算输入信号与云端存储的数据库中脑电信号模式之间的差异；Then, the derived characteristic signal is sent to the cloud through the wireless communication device of the fixed cover (2), as the input signal of the RBF neural network, and a set of dynamic estimators are constructed by using the neural network to calculate the input signal and the database stored in the cloud. Differences between EEG signal patterns;若输入信号与数据库中的癫痫发作先兆期信号差异最小，则该输入信号判断为癫痫发作先兆期信号；若输入信号与数据库中的癫痫发作间期信号差异最小，则该输入信号判断为癫痫发作间期信号；若输入信号与数据库中的癫痫发作期信号差异最小，则该输入信号判断为癫痫发作期信号；If the difference between the input signal and the pre-epileptic seizure signal in the database is the smallest, the input signal is judged to be a pre-epileptic seizure signal; if the difference between the input signal and the epileptic seizure signal in the database is the smallest, the input signal is judged to be an epileptic seizure Interval signal; if the difference between the input signal and the epileptic seizure signal in the database is the smallest, the input signal is judged as the epileptic seizure signal;对于判断为癫痫发作先兆期的信号，云端将该判断结果发送回固定盖(2)内部的微处理器，进行脑刺激。For the signal judged to be the pre-epileptic seizure phase, the cloud sends the judgment result back to the microprocessor inside the fixed cover (2) for brain stimulation.5.如权利要求4所述的一种可穿戴式癫痫监测设备，其特征在于：所述其他状态为癫痫发作间期和癫痫发作期，所述脑电信号模式包括癫痫发作先兆期信号、癫痫发作间期信号和癫痫发作期信号。5. A wearable epilepsy monitoring device as claimed in claim 4, characterized in that: the other states are epileptic seizure period and epileptic seizure period, and the EEG signal pattern comprises epileptic seizure precursor signal, epilepsy Interictal and ictal signals.6.如权利要求3所述的一种可穿戴式癫痫监测设备，其特征在于：所述穿戴装置(3)通过提示灯(3.4)闪烁、喇叭(3.7)发出提示音和震动头(3.8)震动的方式告知癫痫患者。6. A wearable epilepsy monitoring device according to claim 3, characterized in that: the wearable device (3) flashes through a prompt light (3.4), a horn (3.7) emits a prompt sound and a vibrating head (3.8) Vibration to inform epilepsy patients.7.如权利要求2所述的一种可穿戴式癫痫监测设备，其特征在于：所述上支撑架(1.2)、下支撑架(1.5)和活动杆(1.7)环绕第一电极(1.1)均匀设置有多个；优选为4-12个。7. The wearable epilepsy monitoring device according to claim 2, wherein the upper support frame (1.2), the lower support frame (1.5) and the movable rod (1.7) surround the first electrode (1.1) There are a plurality of uniformly arranged; preferably 4-12.8.如权利要求1所述的一种可穿戴式癫痫监测设备，其特征在于：所述下夹持端(1.10)为弹性体，在将植入式电极装置(1)插入到颅骨开设的孔中时，下夹持端(1.10)可被压缩产生形变，在插入之后恢复，并且在夹持时是柔性夹持。8 . The wearable epilepsy monitoring device according to claim 1 , wherein the lower clamping end ( 1.10 ) is an elastic body, and the implantable electrode device ( 1 ) is inserted into the opening of the skull. 9 . When in the hole, the lower gripping end (1.10) can be compressed to deform, recover after insertion, and is a flexible grip when gripped.

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