CN110975719A - A high-throughput experimental liquid dosing system and method for catalytic materials - Google Patents

Abstract

Translated fromChinese

一种催化材料的高通量实验配液系统和方法，涉及试验方法技术领域。高通量配液机构，其设置有多个注射泵、多个助剂烧杯、多个配液试管、取液及滴定装置、磁力搅拌装置、摇床装置、控制装置以及催化材料高通量自动合成平台监控系统，通过在平台监控系统上设置实验所需不同组分配比方式，让后控制装置根据不同组分配比控制取液、放液进行自动化配液，并且取液放液装置可以在三维方向上进行移动取液、放液，满足高通量配比的需求，确保了实验结果的准确性。本发明的高通量移液机构及方法和催化材料的高通量制备系统具有实验结果精度高、数字化、自动化的特点。A high-throughput experimental liquid dispensing system and method for catalytic materials relate to the technical field of test methods. High-throughput liquid dispensing mechanism, which is provided with multiple syringe pumps, multiple auxiliary beakers, multiple liquid dispensing test tubes, liquid taking and titration devices, magnetic stirring devices, shaking table devices, control devices and high-flux automatic catalytic materials. The platform monitoring system is synthesized. By setting the different component distribution ratios required for the experiment on the platform monitoring system, the post-control device can control the liquid collection and discharge according to different component distribution ratios to perform automatic liquid distribution, and the liquid collection and discharge device can be in three-dimensional. The mobile liquid collection and discharge are carried out in the direction to meet the needs of high-throughput ratio and ensure the accuracy of the experimental results. The high-throughput pipetting mechanism and method and the high-throughput preparation system of the catalytic material of the present invention have the characteristics of high precision, digitization and automation of experimental results.

Description

High-flux experiment liquid preparation system and method for catalytic material

Technical Field

The invention relates to the field of a high-flux experimental preparation method system for a catalytic material, in particular to a high-flux pipetting mechanism and method and a high-flux preparation system for the catalytic material.

Background

High throughput pipetting mechanisms are extremely useful as fine research tools for laboratory personnel and are one of the basic operations for each study. At present, liquid transferring guns are mostly used in the processes of reagent proportioning and titration, the liquid taking and discharging processes of the instruments need manual operation, and the problems of liquid leakage, forgetting to rinse and the like easily occur. The invention aims at the fact that high-flux proportioning catalytic materials need 4-8 groups of auxiliary agents to prepare 25 different groups of mixed liquid for experiments, but high-flux proportioning is complex at present, liquid preparation processes are complex, multiple components need to be prepared through successive liquid extraction and titration, the volume of the prepared liquid required by titration for each liquid extraction is small, the prepared liquid cannot be stored, and the prepared liquid is only 2-6ml generally. Join in marriage the unable stirring of liquid, and the precision can not effectively be guaranteed, and can not provide the former stirring of joining in marriage the liquid, hardly get the control when joining in marriage the liquid and get the liquid volume to join in marriage that the liquid is accomplished back gained and can not carry out even stirring and evenly adhere to on the carrier to the accuracy nature of experimental result can not be guaranteed. Therefore, an automatic reagent proportioning workstation which is accurate in quantification, high in control precision, strong in working reliability, high in intelligent degree, capable of stirring for multiple times, economical and reasonable is constructed, and practical research significance and application value are achieved.

Disclosure of Invention

Aiming at the problems, the invention provides a mechanism and a method for stirring, taking and storing an auxiliary agent, a mechanism and a method for accurately preparing liquid with high flux and stirring mixed liquid, and a high-flux preparation system of a catalytic material.

The invention provides a high-flux liquid distribution system, which comprises a uniform mixing device (3), a liquid distribution test tube rack (4), a liquid distribution test tube (5), an accurate liquid taking and discharging mechanism (6), a plurality of auxiliary agent beakers (7), a magnetic stirring device (8) and a monitoring system, wherein the uniform mixing device is arranged on the upper surface of the auxiliary agent beaker; the auxiliary agent beakers (7) are placed on the magnetic stirring device (8), and the liquid preparation test tubes (5) are placed in the liquid preparation test tube rack (4) and are placed on the uniform mixing device (3) together;

the accurate liquid taking and discharging mechanism (6) comprises two first sliding blocks (111), two first lead screws (112), two first lead screw sliding tables (11), two first supports (12), a second support (14), a first cross beam (18), a second sliding block (151), a second lead screw (152), a second lead screw sliding table (15), a plurality of third lead screw sliding blocks (161), a plurality of third lead screws (162), a plurality of third lead screw sliding tables (16), a power part (comprising a motor and the like) and a liquid taking part (17);

the two first screw rod sliding tables (11) are arranged in parallel at intervals along a first direction A, and each first screw rod sliding table (11) is provided with a first sliding block (111) and a first screw rod (112); a first support (12) along a third direction C is fixed on each first sliding block (111), a second support (14) along a second direction is fixed between the top ends of the two first supports (12), a second lead screw sliding table (15) along the second direction is fixed on each second support (14), and each second lead screw sliding table (15) is provided with a second sliding block (151) and a second lead screw (152); the first cross beam (18) is fixed on the second sliding block (151) along a first direction A; a plurality of third screw rod sliding tables (16) which are parallel and are arranged along a third direction C are fixedly distributed on the surfaces of the two sides of the first cross beam (18), each third screw rod sliding table (16) is provided with a third screw rod sliding block (161) and a third screw rod (162), and meanwhile, each third screw rod sliding block (161) is also fixedly provided with a liquid taking part (17) along the third direction C; the matching relationship among the corresponding screw sliding table, the corresponding sliding block and the corresponding screw is as follows: the lead screw sliding table is provided with a guide rail along the corresponding length direction, the lead screw is parallel to the guide rail, the lead screw penetrates through the sliding block, the sliding block is matched with the guide rail and can freely slide along the guide rail, a lead screw pair structure is formed between the lead screw and the sliding block, and the sliding block can be driven to slide along the guide rail through the rotation of the lead screw; the first direction A is marked as an x-axis direction, the second direction B is marked as a y-axis direction, the third direction C is marked as a z-axis direction, and every two directions are perpendicular to each other; the uniform mixing device (3), the liquid preparation test tube rack (4), the liquid preparation test tube (5), the multiple auxiliary agent beakers (7) and the magnetic stirring device (8) are all positioned between the two first lead screw sliding tables (11) and below the second support (14); each lead screw is controlled to rotate by a motor; the liquid taking part (17) is preferably an injector with a downward needle, and the injector is matched with a corresponding stepping motor for use; or the liquid taking part (17) is: the injection pump (not shown in the figure) is connected to the upper part of the hose to provide power for liquid in the hose;

the uniform mixing device (3) comprises a lower workbench (31), a direct current motor (32) with a rotating shaft along a third direction, a motor flange plate (33) with a hole in the middle, three rocker arms (34), two optical axes (35), an upper workbench (36), three short shafts (37), two bearing seats and a bearing (38); the rocker arm (34) is of a flat plate structure with two axially parallel but perpendicular flat plate holes, namely a hole A and a hole B, and a space is arranged between the two holes; the direct current motor (32) is fixed on the lower workbench (31), a motor flange sheet (33) with a hole in the middle is positioned on the direct current motor (32), the rotating shaft of the direct current motor (32) vertically faces the hole of the motor flange sheet (33), and the motor flange sheet (33) is fixed with the lower workbench (31); the rotating shaft of the flow motor (32) is coaxially fixed with a hole A of a rocker arm, a short shaft (37) is coaxially inserted into another hole B, the hole B and the short shaft (37) can rotate relatively, and the top end of the short shaft (37) is fixed with the lower surface of the upper workbench (36); the top ends of the other short shafts (37) are respectively fixed with the lower surface of the upper workbench (36), the lower ends of the other short shafts are respectively and correspondingly inserted into a hole B of a rocker arm, the hole B and the correspondingly inserted short shaft (37) can rotate relatively, the upper end of an optical axis (35) is coaxially inserted and fixed in a hole A of the corresponding rocker arm, the lower end of the corresponding optical axis (35) is coaxially inserted and fixed in a bearing (38), and the bearing (38) is fixed on the lower workbench (31) through a bearing seat; three short shafts (37) are distributed in a triangular shape below the lower workbench (31).

The monitoring system comprises respective control elements or control devices for controlling the motor corresponding to the lead screw, the injection pump or the stepping motor and the direct current motor (32).

The test method comprises the following steps:

respectively placing the raw materials in different auxiliary agent beakers after preparation; the control device controls a piston connected with an injection pump or a stepping motor in the liquid taking part to do reciprocating motion, the injection pump or the piston is pulled to absorb liquid obtained in the auxiliary beaker and store the liquid in the injector, the control device controls a motor corresponding to the lead screw so as to control the injector to move along the directions of an x axis, a y axis and a z axis, the needle head of the injector reaches a corresponding liquid preparation test tube, and then the injection pump pushes the piston of the injector to titrate the liquid outwards through the control device;

respectively sucking auxiliary agents with different components from a plurality of auxiliary agent beakers, and storing the auxiliary agents in the injectors in mutually independent storage;

respectively transferring the mixture into a plurality of liquid preparation test tubes from an injector according to the component proportion designed by the experiment to mix so as to obtain a mixed liquid with a plurality of different component proportions,

the corresponding motor and the injection pump are accurately controlled through timer interruption in the liquid suction and discharge process to ensure the liquid taking and discharging amount and the accuracy of the experimental result.

The uniform mixing device is controlled to shake up the mixed solution, and the mixed solution is attached to the carrier when the carrier is placed in the solution preparation test tube (5).

The invention provides a high-flux preparation system of a catalytic material, which comprises a high-flux liquid distribution mechanism, a configuration mechanism and a platform monitoring system, wherein the configuration mechanism is used for obtaining the catalytic material with higher evaluation on the high-flux liquid distribution mechanism, and the platform monitoring system is used for carrying out dosage monitoring and real-time liquid distribution display on the catalytic material with high-flux ratio in the configuration mechanism.

The invention also provides a horizontal rotation oscillation system prepared from the high-flux catalytic material, which comprises a shaking table driven by the motion of a motor controlled by an upper computer to horizontally rotate and oscillate by the mixed liquid after the high-flux catalytic material is proportioned, so that the prepared catalytic material is driven to be fully shaken uniformly and attached to carriers such as alumina and the like.

Compared with the prior art, the high-flux liquid distribution mechanism disclosed by the invention can be used for automatically distributing liquid at high flux and automatically taking liquid in a three-dimensional direction, is high in automation degree, can be used for simultaneously configuring mixed liquid with various different component distribution ratios so as to meet the requirements of high-flux different components on liquid distribution as required, and can be used for accurately controlling the liquid taking and discharging amount by monitoring the work of the motor through the platform monitoring system, so that the accuracy of an experimental result is ensured.

In addition, the accurate liquid preparation mechanism is also provided with a liquid assisting device and a prepared uniform catalytic material mixing device, so that the obtained liquid is mixed more fully, and the experimental result is more accurate.

Compared with the prior art, the high-flux liquid preparation method can be used for simultaneously preparing the mixed liquid with different component proportion ratios, meets the requirement of high-flux proportioning catalytic materials, accurately controls the liquid taking and discharging amount by monitoring the work of the motor through the platform monitoring system, and ensures the accuracy of experimental results.

Compared with the prior art, the high-flux preparation system for the catalytic material can be used for automatic high-flux liquid preparation and liquid taking by moving in the three-dimensional direction, is high in automation degree, can meet the requirement of high-flux proportioning through the preparation of mixed liquid with various components in proportion, and can accurately control the liquid taking and discharging amount by monitoring the work of the motor through the platform monitoring system, so that the accuracy of an experimental result is ensured.

Compared with the prior art, the horizontal rotation oscillation system can fully shake the mixed liquid before liquid taking and after liquid discharging, meets the requirement of high-flux proportioning of the mixed liquid, accurately controls the liquid taking and discharging amount by monitoring the work of the motor through the platform monitoring system, and ensures the accuracy of experimental results.

Drawings

FIG. 1 is a schematic view of a high throughput dispensing configuration of a first embodiment of the present invention;

FIG. 2 is a schematic view of an electrical connection module of the precise liquid-fetching mechanism according to the first embodiment of the present invention;

FIG. 3 is a schematic structural diagram of a first apparatus according to a first embodiment of the present invention;

FIG. 4 is a schematic view of a three-direction slide table structure of the first apparatus according to the first embodiment of the present invention;

FIG. 5 is a schematic view of a liquid-dispensing horizontal rotation oscillation structure according to a first embodiment of the present invention;

FIG. 6 is a flow chart of a high-throughput liquid dispensing method according to a second embodiment of the present invention.

High flux experiment joins in marriage liquid system 1,workstation 2, homogeneous mixing device 3, join in marriage liquid test-tube rack 4, join in marriage liquid test tube 5, theliquid mechanism 6 of putting is got to accurate liquid, auxiliary agent beaker 7,magnetic stirring device 8,first slider 111,first lead screw 112, first lead screw slip table 11,first support 12,second support 14,first crossbeam 18,second slider 151,second lead screw 152, second lead screw slip table 15, thirdlead screw slider 161, a plurality ofthird lead screw 162, third lead screw slip table 16, getliquid 17,lower workstation 31, a directcurrent motor 32, amotor flange piece 33, threerocking arm 34, twooptical axes 35, an upper table 36, threeminor axis 37.

Detailed Description

In order to make the purpose, technical solution and advantages of the present invention more apparent, the present invention will be described in detail with reference to the accompanying drawings and examples. It should be understood that the specific embodiments described herein are merely illustrative of the invention and do not limit the invention.

Example 1

Referring to fig. 1, a high throughput pipetting mechanism 1 according to a first embodiment of the present invention includes aworktable 2, a uniform mixing device 3, a solution preparation test tube rack 4, a solution preparation test tube 5, an accurate solution taking anddischarging mechanism 6, a plurality of auxiliary agent beakers 7, amagnetic stirring device 8, and a platform monitoring system. The auxiliary agent beakers 2, the liquid preparation test tubes 5, the accurate liquid taking anddischarging mechanism 6, the control device (not shown) and the uniform mixing device 3 are all arranged on theworkbench 2. As a simplification, the working table 2 can be omitted, and the auxiliary agent beaker 7, the liquid preparation test tube 5, the liquid taking and discharging device 3, the control device and the uniform mixing device 3 are arranged on a bearing plane.

The plurality of auxiliary agent beakers 7 are used for storing stock solutions with different components independently, and the plurality of solution preparation test tubes 5 are used for storing a plurality of mixed solutions obtained by mixing the stock solutions with different components sucked in the auxiliary agent beakers 7 according to different component preparation ratios independently.

The platform monitoring system generally consists of an upper computer monitoring PC. Referring to fig. 2, the platform monitoring system is connected to a control device, the three-dimensional control element of the liquid taking and discharging mechanism is connected to the control device, the control device can feed back the rotation speed of the motor and the height of the liquid level ascending and descending through an autonomous design algorithm according to the movement distance of the sliding block in the three-dimensional direction, and the control device can control the working state of the motor in the three-dimensional direction according to the feedback of the platform monitoring system. The control device is preset with a preset value of liquid level descending height calculated according to the pre-fetching calculated liquid amount, the platform monitoring system sends a pulse signal to the control device, the control device controls the liquid fetching anddischarging device 6 to fetch liquid in the auxiliary agent beaker according to the signal, when the control device stops sending the pulse signal, the liquid fetching device stops fetching liquid, and the platform monitoring system displays the descending liquid level height and the liquid fetching amount of the liquid fetching device in real time. When the liquid is taken, the control device transmits an electric signal to each control element to control the position and the moving speed of the sliding block, the liquid taken from the auxiliary agent beaker is stored in the injection pump, the liquid taking and discharging device is controlled to match the taken liquid according to the grouping of experimental design, the injection pump is controlled to move above each liquid preparation test tube according to the setting of the platform monitoring system, the auxiliary agent is titrated into the liquid preparation test tubes by controlling the injection pump to inject the preset liquid amount, and the liquid in each injection pump is stored independently. It will be appreciated that the control module may also control the rate and location of the draw of the dope from the additive beaker by the tapping means 6. The platform monitoring system can also be provided with component proportion of various experimental designs, and the control device controls the liquid takingdevice 6 to accurately absorb stock solutions with different components from different auxiliary agent beakers according to the component proportion of each group of experimental designs, so that automatic liquid distribution is realized.

The volume of the auxiliary agent beaker 7 is 3-5 times of the volume of the liquid preparation test tube 5, the diameter of theauxiliary agent beaker 2 is 50-55mm, and the diameter of the liquid preparation test tube 5 is 28-38 mm. Preferably, the aid beaker 7 is a container with a volume of 20ml, and the number of the aid beaker is 4-8 so as to store the aid. The liquid preparation test tubes 5 are containers with the diameter of 35ml and the volume of 25ml, and the number of the liquid preparation test tubes is 25, so that 25 screens with different proportions can be simultaneously carried out, and the preparation requirement of high flux is met. The beaker auxiliary agent has a slightly larger volume so as to provide enough auxiliary agent for high-flux liquid preparation, and the liquid preparation test tube has a smaller volume than the beaker auxiliary agent so as to ensure that the liquid level height changes more sensitively, and the liquid level height can monitor and feed back when finding slight changes in time, thereby ensuring that the result is more accurate. As a deformation, the volume and the number of the auxiliary agent beakers and the liquid preparation test tubes can be designed according to the experimental requirements.

Referring to fig. 3, the precise liquid taking anddischarging device 6 includes twofirst sliders 111, twofirst screws 112, two first screw sliding tables 11, twofirst brackets 12, twofirst corner connectors 13, asecond bracket 14, afirst cross beam 18, asecond slider 151, twosecond screws 152, a second screw sliding table 15, eightthird screw sliders 161, eightthird screws 162, eight third screw sliding tables 16, a power component, and a liquid takingcomponent 17. Thefirst beam 18 is fixed to thesecond slider 15/1 along the first direction a, and the fastening connection between the first beam and thesecond slider 15/1 can be a screw connection, a welding connection, a riveting connection or an adhesive connection. The eight groups of third sliding blocks are respectively fixed on the surfaces of the two sides of the first cross beam in an array mode and fixed with the third screw rod sliding table along the third direction, and the third sliding blocks are connected with the first cross beam in a screw fastening mode. Therefore, the third slide table 16 can move in the first direction a, the second direction B and the third direction C, so as to facilitate the taking and placing of the liquid in a wide range.

Please refer to fig. 4. Two first lead screw slip tables 11 interval sets up onworkstation 2, and the axial direction of first lead screw slip table 11 is first direction A. Through the first screw sliding table 11, the firstscrew sliding block 111 and the first screw are formed into a screw pair through threads (or balls) to realize linear reciprocating motion. In the same way, thesecond slider 151, the twosecond lead screws 152 and the second lead screw sliding table 15 realize linear reciprocating motion, and the thirdlead screw slider 161, thethird lead screw 162 and the third lead screw sliding table 16 realize linear reciprocating motion.

The power part comprises 11 stepping motors, and the corresponding lead screws are connected with the power part through shaft couplings to drive the lead screws to rotate. Get and put liquid spare 17 and include syringe needle and hose, glue respectively to connect to 8 third slip table backs along the third direction to guarantee the liquid flow direction. The upper part of the hose is connected with a syringe pump (not shown) for providing power for the liquid in the hose.

Referring to fig. 5, the first embodiment of the present invention further provides a liquid preparation horizontal rotation oscillation uniform mixing device 3. The liquid distribution horizontal rotation oscillation uniform mixing device 3 comprises alower workbench 31, a directcurrent motor 32, amotor flange plate 33, threerocker arms 34, twooptical axes 35, anupper workbench 36, threeshort shafts 37, and two bearing seats and bearings 28. The stepping motor is connected with the control device through a control element, the pulse number of the stepping motor is controlled, the rotating speed of the motor is further controlled, and the motor and the bearing seat are fixedly connected in a mode that screws are connected on the working table top of the uniform mixing device 3. The motor shaft passes in the rocker hole and through holding screw fixed, and the bearing is embedded to the bearing frame in, and its cooperation mode is clearance fit. The optical axis and the rocker arm are connected by a set screw. Controlling means control motor rotates, and motor shaft connecting rocking arm is circular motion around the motor axial to drive other two rocking arms and be synchronous circular motion, thereby drive the horizontal rotation of workstation and vibrate, go up the workstation and be connected with joining in marriage the liquid test tube, both fastening connection's mode can be screw connection, welding, riveting or splice.

Referring to fig. 6, the second embodiment of the present invention further provides a high-throughput liquid distribution method, which uses the high-throughput liquid distribution mechanism 1 as described above, and the high-throughput liquid distribution method includes the following steps:

step S1: and uniformly stirring the beaker auxiliary agent in a mechanical stirring manner, a magnetic stirring manner, an ultrasonic stirring manner or a manual stirring manner. Preferably, the stirring mode of the beaker auxiliary agent is selected from magnetic stirring.

Step S2: the auxiliary agents with different components are respectively sucked from a plurality of beakers and stored in a plurality of injection pumps independently.

Step S3: according to a plurality of component distribution ratios designed by the platform monitoring system, different component auxiliaries sucked in the injection pump are titrated into a liquid preparation test tube according to preset auxiliaries and are mixed to obtain mixed liquid with a plurality of different component distribution ratios, and the component ratios of catalytic components obtained in each liquid preparation test tube are different from each other.

In the process of suction titration, the stepping motor is accurately controlled, the rotating speed and the number of pulses of the motor are monitored in the platform monitoring system, and meanwhile, the platform monitoring system displays the working state of the feedback motor in real time so as to realize accurate control of liquid taking and discharging amount.

Preferably, the high-throughput liquid preparation method may further include step S4;

step S4: and (3) uniformly mixing, namely uniformly mixing the mixed solution, wherein the uniform stirring mode can be mechanical stirring, magnetic stirring, ultrasonic stirring or manual stirring. Preferably, the means of uniform mixing is selected from mechanical stirring.

The invention also provides a high-flux preparation system of the catalytic material. The high-throughput pipetting mechanism 1 is adopted, and in the embodiment, the high-throughput pipetting mechanism 1 comprises 8 auxiliary agent beakers 7 with the volume of 20ml, 8 syringe pumps and 25 liquid preparation test tubes 5 with the diameter of 35ml and the volume of 25 ml. The high-flux preparation system of the catalytic material further comprises a configuration mechanism and a testing mechanism, wherein the configuration mechanism is used for carrying out condition configuration on the catalytic material on the mixed liquid obtained by the high-flux liquid distribution mechanism 1, and the testing mechanism is used for carrying out catalytic performance testing on the mixed liquid which is subjected to catalytic material configuration in the configuration mechanism.

For the configuration of the catalytic material, the component screening of the catalytic auxiliary agents with different component distribution ratios is usually carried out simultaneously, the catalytic materials with different ratios can obtain different catalytic performances, a person skilled in the art can select the corresponding component distribution ratios according to the catalytic performance test, the catalytic material is configured according to high flux to realize the attachment of the high flux component carrier, and the catalytic material required to be configured can realize the screening only by a small amount of catalytic material. In the following description, the stock solution refers to an auxiliary agent for preparing a catalytic material, which includes but is not limited to three components of ethylenediamine, silver oxalate and water to be screened, and may also be four or more components, and the auxiliary agents of different components may be prepared into catalytic materials with different properties according to different pre-designed proportions, wherein the auxiliary agents may be directly added into an auxiliary agent beaker, and the auxiliary agents in the beaker are respectively added into a solution preparation test tube in proportion through the proportions. The high-throughput liquid preparation process for preparing the catalytic material in high-throughput manner is described in detail below.

Ethylenediamine, silver oxalate and water were stored independently of each other in 8 additive beakers. And then, absorbing the ethylenediamine, the silver oxalate and the water from the auxiliary agent beaker into a syringe pump, taking the specific quantity distribution according to the component proportion designed in advance through experiments, taking the liquid by using a control device according to the different component proportions designed in advance, titrating the liquid into 25 liquid-distributing test tubes, and mixing the liquid and the test tubes to obtain 25 catalytic materials with different distribution ratios. It can be understood that the control device can control the liquid taking and discharging device to move in the three-dimensional direction, so that automatic proportioning is realized.

The 25 different component ratios can be designed for verifying the influence of the carrier attached by the mixed liquid with different ratios on the catalytic performance or for obtaining large-scale experimental data, such as: in order to verify the influence of a certain catalytic material on the catalytic performance of a certain reaction, 25 groups of different component ratios are designed in advance, and the weight ratio of ethylene diamine, silver oxalate and water is from 1: 1: 1. 1: 1: 2. 1: 2: 2, the preset volume of the catalytic mixed solution is 5ml, and the optimal component proportion is screened out according to the catalytic performance result of the catalytic material after the catalytic mixed solution is attached to the carrier. Because the volume of the catalytic mixed liquid prepared by the ethylenediamine, the silver oxalate and the water required by the test is smaller, the stepper motor needs to be accurately controlled, and the accuracy of the experimental result is ensured.

Compared with the prior art, the high-flux liquid-transferring mechanism can perform automatic high-flux proportioning and liquid taking in the three-dimensional direction, is high in automation degree, can simultaneously perform the preparation of mixed liquid with various different component proportioning ratios, meets the requirement of high-flux screening, and ensures the accuracy of an experimental result through the accurate pulse control of the stepping motor interrupted by the timer.

Additionally, the accurate liquid preparation mechanism is also provided with a magnetic stirring device and a horizontal rotating table uniform mixing device, so that the mixing is more sufficient, and the experimental result is more accurate.

Compared with the prior art, the high-flux liquid transfer method can be used for simultaneously preparing the mixed liquid with a plurality of component distribution ratios, meets the requirement of high-flux screening, and ensures the accuracy of an experimental result through the accurate pulse control of the stepping motor interrupted by the timer.

Compared with the prior art, the high-flux preparation system for the catalytic material can be used for automatically preparing high-flux liquid, can be used for moving liquid taking and discharging in the three-dimensional direction, is high in automation degree, can be used for preparing mixed liquid with various component distribution ratios at the same time, meets the requirement of high-flux screening, and ensures the accuracy of an experimental result through the accurate pulse control of the stepping motor interrupted by the timer.

The above description is only for the purpose of illustrating the preferred embodiments of the present invention and is not to be construed as limiting the invention, and any modifications, equivalents and improvements made within the spirit of the present invention are intended to be included within the scope of the present invention.

Claims (3)

Translated fromChinese

1.一种高通量配液系统，其特征在于，所述高通量配液系统包括均匀混合装置(3)、配液试管架(4)、配液试管(5)、精准取液放液机构(6)、多个助剂烧杯(7)、磁力搅拌装置(8)、监控系统；所述多个助剂烧杯(7)放置在磁力搅拌装置(8)上，配液试管(5)放置到配液试管架(4)中并一起放置到均匀混合装置(3)上；1. a high-throughput liquid dispensing system, is characterized in that, the high-throughput liquid dispensing system comprises a uniform mixing device (3), a liquid dispensing test tube rack (4), a liquid dispensing test tube (5), a precise liquid dispensing Liquid mechanism (6), multiple auxiliary beakers (7), magnetic stirring device (8), monitoring system; the multiple auxiliary beakers (7) are placed on the magnetic stirring device (8), and the liquid dispensing test tube (5) ) are placed in the dosing test tube rack (4) and placed together on the uniform mixing device (3);精准取液放液机构(6)包括两第一滑块(111)、两第一丝杠(112)、两第一丝杠滑台(11)、两第一支架(12)、第二支架(14)、第一横梁(18)、第二滑块(151)、第二丝杠(152)、第二丝杠滑台(15)、多个第三丝杠滑块(161)、多个第三丝杠(162)、多个第三丝杠滑台(16)、动力件(包括电机等)以及取液件(17)；The precise liquid taking and discharging mechanism (6) includes two first sliding blocks (111), two first lead screws (112), two first lead screw slide tables (11), two first brackets (12), and a second bracket (14), a first beam (18), a second slider (151), a second screw (152), a second screw slide (15), a plurality of third screw sliders (161), a plurality of a third lead screw (162), a plurality of third lead screw slide tables (16), a power component (including a motor, etc.), and a liquid taking component (17);两第一丝杠滑台(11)沿第一方向A平行间隔设置，每个第一丝杠滑台(11)上配置有一个第一滑块(111)和一个第一丝杠(112)；每个第一滑块(111)上固定有沿第三方向C的第一支架(12)，在两第一支架(12)的顶端之间固定有沿第二方向的第二支架(14)，第二支架(14)上固定有沿第二方向第二丝杠滑台(15)，第二丝杠滑台(15)配有第二滑块(151)和第二丝杠(152)；所述第一横梁(18)沿第一方向A固定于第二滑块(151)上；第一横梁(18)两侧表面固定分布有多个平行的沿第三方向C的第三丝杠滑台(16)，每个第三丝杠滑台(16)各配有一个第三丝杠滑块(161)和第三丝杠(162)，同时每个第三丝杠滑块(161)上还固定有沿沿第三方向C的取液件(17)；上述的对应的丝杠滑台、滑块、丝杠之间的匹配关系为：丝杠滑台设有沿对应长度方向的导轨，丝杠与导轨平行，且丝杠穿过滑块，滑块与导轨匹配可沿导轨自由滑动，丝杠与滑块之间为形成丝杆副结构，通过丝杠的转动可驱动滑块沿导轨滑动；所述第一方向A记为x轴方向，第二方向B记为y轴方向、第三方向C记为z轴方向，两两互相垂直；均匀混合装置(3)、配液试管架(4)、配液试管(5)、多个助剂烧杯(7)、磁力搅拌装置(8)均位于两第一丝杠滑台(11)之间、第二支架(14)之下；每个丝杠分别各通过一个电机控制转动；取液件(17)优选为针头向下的注射器，注射器与对应的步进电机配合使用；或取液件(17)为：包括针头以及软管，沿第三方向分别胶接至8个第三滑台背部，以保证液体流向，软管上部连接注射泵(图未示)，为软管内液体提供动力；The two first lead screw slide tables (11) are arranged in parallel and spaced apart along the first direction A, and each first lead screw slide platform (11) is provided with a first slider (111) and a first lead screw (112) ; A first bracket (12) along the third direction C is fixed on each first slider (111), and a second bracket (14) along the second direction is fixed between the top ends of the two first brackets (12). ), a second lead screw slide table (15) in the second direction is fixed on the second bracket (14), and the second lead screw slide table (15) is equipped with a second slider (151) and a second lead screw (152) ); the first beam (18) is fixed on the second slider (151) along the first direction A; the surfaces on both sides of the first beam (18) are fixedly distributed with a plurality of parallel thirds along the third direction C A lead screw slide (16), each third lead screw slide (16) is provided with a third lead screw slide (161) and a third lead screw (162), and each third lead screw slide (161) is also fixed with a liquid sampling member (17) along the third direction C; the above-mentioned matching relationship between the corresponding lead screw slide table, slide block and lead screw is: the lead screw slide table is provided with a corresponding For the guide rail in the length direction, the lead screw is parallel to the guide rail, and the lead screw passes through the slider. The slider and the guide rail can be matched and can slide freely along the guide rail. The screw pair structure is formed between the lead screw and the slider. The sliding block is driven to slide along the guide rail; the first direction A is denoted as the x-axis direction, the second direction B is denoted as the y-axis direction, and the third direction C is denoted as the z-axis direction, and the two are perpendicular to each other; the uniform mixing device (3) , the liquid dispensing test tube rack (4), the liquid dispensing test tube (5), a plurality of auxiliary beakers (7), and the magnetic stirring device (8) are all located between the two first screw slide tables (11), and the second bracket ( 14) below; each lead screw is controlled to rotate by a motor respectively; the liquid taking part (17) is preferably a syringe with a needle downward, and the syringe is used in conjunction with a corresponding stepping motor; or the liquid taking part (17) is: Including needles and hoses, which are glued to the backs of 8 third slide tables in the third direction to ensure the flow of liquids, and the upper part of the hoses is connected to a syringe pump (not shown) to provide power for the liquid in the hoses;所述的均匀混合装置(3)包括一个下工作台(31)、一个转动轴沿第三方向的直流电机(32)、一个中间带孔的电机法兰片(33)、三个摇臂(34)、两个光轴(35)、一个上工作台(36)、三个短轴(37)、两个轴承座及轴承(38)；摇臂(34)的结构为一个平板结构上带有两个轴向平行却垂直平板的孔即孔A和孔B，此两孔之间有间隔；直流电机(32)固定到下工作台(31)上，中间带孔的电机法兰片(33)位于直流电机(32)上面，直流电机(32)的转动轴上下对着电机法兰片(33)的孔，电机法兰片(33)与下工作台(31)固定到一起；流电机(32)的转动轴与一个摇臂的孔A同轴固定到一起，另一个孔B内同轴插入一个短轴(37)，孔B与此短轴(37)之间可相对转动，此短轴(37)的顶端与上工作台(36)下表面固定在一起；其余的短轴(37)的顶端分别与上工作台(36)下表面固定在一起，下端分别各对应插入一个摇臂的孔B中，孔B与此对应插入的短轴(37)之间可相对转动，对应的摇臂的孔A内同轴插入固定一个光轴(35)的上端，对应光轴(35)的下端同轴插入固定到一个轴承(38)中，轴承(38)通过轴承座固定到下工作台(31)上；三个短轴(37)在下工作台(31)下面成三角形分布；The uniform mixing device (3) comprises a lower worktable (31), a DC motor (32) with a rotating shaft along the third direction, a motor flange plate (33) with a hole in the middle, and three rocker arms ( 34), two optical axes (35), an upper table (36), three short axes (37), two bearing seats and bearings (38); the structure of the rocker arm (34) is a flat plate structure with an upper belt There are two axially parallel but vertical flat holes, namely hole A and hole B, and there is an interval between the two holes; the DC motor (32) is fixed on the lower worktable (31), and the motor flange with a hole in the middle ( 33) is located above the DC motor (32), the rotating shaft of the DC motor (32) faces the holes of the motor flange (33) up and down, and the motor flange (33) and the lower table (31) are fixed together; The rotating shaft of the motor (32) is coaxially fixed with the hole A of the rocker arm, and a short shaft (37) is coaxially inserted into the other hole B, and the hole B and the short shaft (37) can rotate relative to each other, The top of the short shaft (37) is fixed with the lower surface of the upper worktable (36); the tops of the other short shafts (37) are respectively fixed with the lower surface of the upper worktable (36), and the lower ends are respectively inserted into one In the hole B of the rocker arm, the hole B and the correspondingly inserted short axis (37) can rotate relatively, and the upper end of an optical axis (35) corresponding to the optical axis ( The lower end of 35) is coaxially inserted and fixed into a bearing (38), and the bearing (38) is fixed to the lower table (31) through the bearing seat; the three short shafts (37) are distributed in a triangle below the lower table (31). ;监控系统包括用于控制丝杠对应的电机、注射泵或步进电机、直流电机(32)的各自的控制元件或控制装置。The monitoring system includes respective control elements or control devices for controlling the motor corresponding to the lead screw, the syringe pump or the stepper motor, and the DC motor (32).2.采用权利要求1的高通量配液系统进行实验的方法，其特征在于，包括以下步骤：2. the method that adopts the high-throughput liquid dosing system of claim 1 to carry out experiment, is characterized in that, comprises the following steps:将各原材料配置后分别放置在不同的助剂烧杯中；通过控制装置控制取液件中的注射泵或步进电机连接的活塞做往复运动，拉动注射泵或活塞吸取助剂烧杯中所取得的液体并存放于注射器中，通过控制装置控制丝杠对应的电机，进而控制注射器沿x轴、y轴、z轴方向上运动，使注射器的针头到达对应的配液试管上，然后注射泵通过控制装置从而推动注射器的活塞向外滴定液体；After configuring each raw material, place it in different auxiliary beakers; control the syringe pump in the liquid-taking part or the piston connected with the stepping motor to reciprocate, and pull the syringe pump or piston to absorb the obtained material in the auxiliary beaker. The liquid is stored in the syringe, and the motor corresponding to the lead screw is controlled by the control device, and then the syringe is controlled to move along the x-axis, y-axis, and z-axis, so that the needle of the syringe reaches the corresponding liquid dispensing test tube, and then the syringe pump is controlled by The device thus pushes the plunger of the syringe to titrate the liquid outward;从多个助剂烧杯中分别吸取不同成分助剂存储于注射器中相互独立的存储；Auxiliaries with different components are drawn from multiple additive beakers and stored in syringes independently of each other;按照实验设计的组分配比分别从注射器中移送至多个配液试管中进行混合以得到多种不同组分配比的混合液，According to the composition ratio of the experimental design, it is transferred from the syringe to multiple dosing test tubes for mixing to obtain a variety of mixed solutions with different composition ratios.在吸液放液过程中通过定时器中断精确控制对应的电机以及注射泵来保证取液、放液量，保证实验结果的准确性。In the process of liquid suction and discharge, the corresponding motor and syringe pump are accurately controlled by timer interruption to ensure the amount of liquid taken and discharged, and the accuracy of the experimental results.3.按照权利要求2所述的方法，其特征在于，控制均匀混合装置摇匀混合液，在配液试管(5)中放置有载体时并使混合液附着至载体上。3. The method according to claim 2, characterized in that the uniform mixing device is controlled to shake the mixed solution evenly, and when a carrier is placed in the liquid dispensing test tube (5), the mixed solution is attached to the carrier.

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