CN110694175A

Movatterモバイル変換

Info

Publication number: CN110694175A
Application number: CN201911059065.2A
Authority: CN
Inventors: 王海峰
Original assignee: Shanghai Ruidao Medical Technology Co Ltd
Current assignee: Shanghai Ruidao Medical Technology Co Ltd
Priority date: 2019-11-01
Filing date: 2019-11-01
Publication date: 2020-01-17

Abstract

Translated fromChinese

本申请提供一种脉冲产生电路及肿瘤治疗装置。脉冲产生电路包括主控制板、RS485接口芯片、电源单元、脉冲产生单元以及切换单元；脉冲产生单元配置有第一处理器，切换单元配置有第二处理器；主控制板的第一UART口连接RS485接口芯片的输入端，RS485接口芯片的输出端通过RS485总线分别连接第一处理器和第二处理器；主控制板的第二UART口连接电源单元，用于控制电源单元产生高压直流电压；脉冲产生单元用于从电源单元接收高压直流电压并将其转变成双极性脉冲电压；切换单元用于从脉冲产生单元接收双极性脉冲电压并将其输出至对应的电极针。通过本申请实施例的脉冲产生电路及肿瘤治疗装置，简化了各板块之间的连接结构，提高抗干扰能力，而且便于维护。

The present application provides a pulse generating circuit and a tumor treatment device. The pulse generating circuit includes a main control board, an RS485 interface chip, a power supply unit, a pulse generating unit and a switching unit; the pulse generating unit is configured with a first processor, and the switching unit is configured with a second processor; the first UART port of the main control board is connected to The input end of the RS485 interface chip and the output end of the RS485 interface chip are respectively connected to the first processor and the second processor through the RS485 bus; the second UART port of the main control board is connected to the power supply unit, which is used to control the power supply unit to generate high-voltage DC voltage; The pulse generating unit is used for receiving the high voltage DC voltage from the power supply unit and converting it into a bipolar pulse voltage; the switching unit is used for receiving the bipolar pulse voltage from the pulse generating unit and outputting it to the corresponding electrode needle. Through the pulse generating circuit and the tumor treatment device of the embodiments of the present application, the connection structure between the plates is simplified, the anti-interference capability is improved, and maintenance is facilitated.

Description

Translated fromChinese

脉冲产生电路及肿瘤治疗装置Pulse generating circuit and tumor treatment device

技术领域technical field

本申请涉及医疗器械领域，特别涉及脉冲产生电路及肿瘤治疗装置。The present application relates to the field of medical devices, and in particular, to a pulse generating circuit and a tumor treatment device.

背景技术Background technique

癌症是危害人类健康的主要疾病。肿瘤的传统疗法以及新近发展起来的以微创消融为特征的热消融物理疗法，由于受适应症、禁忌症、治疗副作用、热效应等因素的限制，使得其临床应用存在一定的局限性。近年来，随着脉冲生物电学的不断发展，电场脉冲以其非热、微创的生物医学效应引起了研究人员的关注，并逐渐应用于肿瘤的临床治疗。Cancer is a major disease endangering human health. Traditional tumor therapy and the newly developed thermal ablation physiotherapy characterized by minimally invasive ablation have certain limitations in clinical application due to the limitations of indications, contraindications, treatment side effects, thermal effects and other factors. In recent years, with the continuous development of pulsed bioelectricity, electric field pulses have attracted the attention of researchers due to their non-thermal and minimally invasive biomedical effects, and have been gradually applied in the clinical treatment of tumors.

电场脉冲治疗肿瘤的原理是通过高压电源和脉冲发生器产生高压超短纳秒脉冲，发射一定频率的超短脉冲，将电能通过电极以脉冲电场形式释放，通过电极针将电场能量传送到肿瘤组织使肿瘤细胞产生不可逆电穿孔而凋亡。The principle of electric field pulse therapy for tumors is to generate high-voltage ultra-short nanosecond pulses through a high-voltage power supply and a pulse generator, emit ultra-short pulses of a certain frequency, release electrical energy through electrodes in the form of pulsed electric fields, and transmit electric field energy to tumor tissue through electrode needles. Causes tumor cells to undergo irreversible electroporation and apoptosis.

现有的技术中的脉冲产生电路采用传统IO口并发控制，IO口数目繁多，连线复杂，导致抗干扰能力差，维修困难等。The pulse generating circuit in the prior art adopts the concurrent control of traditional IO ports, the number of IO ports is numerous, and the wiring is complicated, resulting in poor anti-interference ability and difficulty in maintenance.

发明内容SUMMARY OF THE INVENTION

本申请提供一种脉冲产生电路及肿瘤治疗装置。The present application provides a pulse generating circuit and a tumor treatment device.

根据本申请实施例的第一方面提供一种脉冲产生电路，应用于包含电极针的肿瘤治疗装置，所述脉冲产生电路包括：主控制板、RS485接口芯片、电源单元、脉冲产生单元以及切换单元；所述脉冲产生单元配置有第一处理器，所述切换单元配置有第二处理器；所述主控制板的第一UART口连接所述RS485接口芯片的输入端，所述RS485接口芯片的输出端通过RS485总线分别连接所述第一处理器和所述第二处理器；所述主控制板的第二UART口连接所述电源单元的输入端，用于控制所述电源单元产生高压直流电压，并输出至所述脉冲产生单元；所述脉冲产生单元的输入端连接所述电源单元的输出端，所述脉冲产生单元响应于所述第一处理器，用于接收所述高压直流电压，并将所述高压直流电压转变成双极性脉冲电压，以及将所述双极性脉冲电压输出至所述切换单元；所述切换单元的输入端连接所述脉冲产生单元的输出端，所述切换单元响应于所述第二处理器，用于接收所述双极性脉冲电压，并将所述双极性脉冲电压输出至对应的所述电极针。According to a first aspect of the embodiments of the present application, a pulse generation circuit is provided, which is applied to a tumor treatment device including electrode needles, the pulse generation circuit includes: a main control board, an RS485 interface chip, a power supply unit, a pulse generation unit, and a switching unit ; The pulse generating unit is configured with a first processor, and the switching unit is configured with a second processor; the first UART port of the main control board is connected to the input end of the RS485 interface chip, and the RS485 interface chip is The output terminal is respectively connected to the first processor and the second processor through the RS485 bus; the second UART port of the main control board is connected to the input terminal of the power supply unit for controlling the power supply unit to generate high-voltage direct current The voltage is output to the pulse generating unit; the input terminal of the pulse generating unit is connected to the output terminal of the power supply unit, and the pulse generating unit is responsive to the first processor for receiving the high voltage DC voltage , and convert the high voltage DC voltage into a bipolar pulse voltage, and output the bipolar pulse voltage to the switching unit; the input end of the switching unit is connected to the output end of the pulse generating unit, so The switching unit is responsive to the second processor and configured to receive the bipolar pulse voltage and output the bipolar pulse voltage to the corresponding electrode needle.

进一步地，所述脉冲产生电路还包括：急停单元；所述急停单元包括第三处理器和急停开关；所述RS485接口芯片的输出端通过所述RS485总线连接所述第三处理器；所述急停单元连接在所述电源单元和所述脉冲产生单元之间；所述急停单元响应于所述第三处理器，在所述急停开关被导通时，切断从所述电源单元接收所述高压直流电压的能量输入，并且切断向所述脉冲产生单元输出所述高压直流电压的能力输出，以及释放能量。Further, the pulse generating circuit further includes: an emergency stop unit; the emergency stop unit includes a third processor and an emergency stop switch; the output end of the RS485 interface chip is connected to the third processor through the RS485 bus ; the emergency stop unit is connected between the power supply unit and the pulse generating unit; the emergency stop unit responds to the third processor, when the emergency stop switch is turned on, cuts off the The power supply unit receives the energy input of the high voltage direct current voltage, and cuts off the output of the capability of outputting the high voltage direct current voltage to the pulse generating unit, and releases the energy.

进一步地，所述脉冲产生电路还包括：第一隔离单元；所述第一隔离单元连接在所述第一UART口与所述RS485接口芯片的输入端之间。Further, the pulse generating circuit further includes: a first isolation unit; the first isolation unit is connected between the first UART port and the input end of the RS485 interface chip.

进一步地，所述脉冲产生电路还包括：第二隔离单元；所述第二隔离单元连接在所述第二UART口与所述电源单元的输入端之间。Further, the pulse generating circuit further includes: a second isolation unit; the second isolation unit is connected between the second UART port and the input end of the power supply unit.

进一步地，所述切换单元包含至少2个切换通道，每个切换通道包含一个单刀双掷开关和一个单刀单掷开关；所述单刀双掷开关的两个不动端分别连接所述双极性脉冲电压的正极性脉冲电压端和负极性脉冲电压端；所述单刀双掷开关的公共端通过所述单刀单掷开关连接至所述电极针；所述单刀双掷开关和所述单刀单掷开关的使能端分别连接所述第二处理器。Further, the switching unit includes at least 2 switching channels, and each switching channel includes a SPDT switch and a SPDT switch; the two fixed ends of the SPDT switch are respectively connected to the bipolar The positive pulse voltage terminal and the negative pulse voltage terminal of the pulse voltage; the common terminal of the SPDT switch is connected to the electrode needle through the SPDT switch; the SPDT switch and the SPST The enabling ends of the switches are respectively connected to the second processors.

进一步地，所述切换通道有8个。Further, there are 8 switching channels.

进一步地，所述主控制板由STM32F2芯片搭建而成。Further, the main control board is constructed by STM32F2 chip.

进一步地，所述第一处理器、所述第二处理器以及所述第三处理器均为ARMCortex-M3处理器。Further, the first processor, the second processor and the third processor are all ARM Cortex-M3 processors.

进一步地，所述RS485接口芯片采用型号为SN65LBC176A系列的芯片。Further, the RS485 interface chip adopts the chip of the SN65LBC176A series.

根据本申请实施例的第二方面提供一种肿瘤治疗装置，包括：至少2个电极针、上位机以及上述的脉冲产生电路；所述上位机通过串口连接所述主控制板；所述电极针连接所述切换单元的输出端。According to a second aspect of the embodiments of the present application, a tumor treatment device is provided, comprising: at least two electrode needles, a host computer, and the above-mentioned pulse generating circuit; the host computer is connected to the main control board through a serial port; the electrode needles Connect the output terminal of the switching unit.

本申请实施例的脉冲产生电路及肿瘤治疗装置，采用RS485主从网络的拓扑结构，主控制板通过RS485串行总线与其他从功能板(脉冲产生单元和切换单元)连接。而且每个从功能板都单独配置有处理器，可以独立工作，主控制板又可以通过RS485网络控制各从功能板协同工作。相对于现有技术中主控制板通过IO口并发控制其它功能板块，减少了连接接口，布线简单，大大简化了各板块之间的连接结构。而且RS485网络采用差分方式传输信号，相较于现有技术中IO口的并发控制，提高了抗干扰能力，能有效提升响应速度。另外，在需要添加新的从功能板时，直接串接到RS485总线上即可，简单方便。在故障维修时，可以只对有故障的功能板进行维修，有利于系统维护。The pulse generation circuit and tumor treatment device of the embodiments of the present application adopt the topology of the RS485 master-slave network, and the master control board is connected to other slave function boards (pulse generation unit and switching unit) through the RS485 serial bus. Moreover, each slave function board is individually configured with a processor, which can work independently, and the main control board can control the slave function boards to work together through the RS485 network. Compared with the prior art, the main control board concurrently controls other functional blocks through the IO port, which reduces the number of connection interfaces, the wiring is simple, and the connection structure between the blocks is greatly simplified. Moreover, the RS485 network transmits signals in a differential manner. Compared with the concurrent control of the IO port in the prior art, the anti-interference ability is improved, and the response speed can be effectively improved. In addition, when a new slave function board needs to be added, it can be directly connected to the RS485 bus, which is simple and convenient. During fault maintenance, only the faulty function board can be repaired, which is beneficial to system maintenance.

应当理解的是，以上的一般描述和后文的细节描述仅是示例性和解释性的，并不能限制本申请。It is to be understood that both the foregoing general description and the following detailed description are exemplary and explanatory only and are not limiting of the present application.

附图说明Description of drawings

此处的附图被并入说明书中并构成本说明书的一部分，示出了符合本申请实施例，并与说明书一起用于解释本发明的原理。The accompanying drawings, which are incorporated in and constitute a part of this specification, illustrate embodiments consistent with the application and together with the description serve to explain the principles of the invention.

图1是本申请一示例性实施例示出的一种脉冲产生电路的结构示意图；FIG. 1 is a schematic structural diagram of a pulse generating circuit shown in an exemplary embodiment of the present application;

图2是本申请一示例性实施例示出的一种脉冲产生单元的结构示意图；2 is a schematic structural diagram of a pulse generating unit shown in an exemplary embodiment of the present application;

图3是本申请一示例性实施例示出的一种切换单元的结构示意图；3 is a schematic structural diagram of a switching unit according to an exemplary embodiment of the present application;

图4是本申请一示例性实施例示出的另一种脉冲产生电路的结构示意图；4 is a schematic structural diagram of another pulse generating circuit shown in an exemplary embodiment of the present application;

图5是本申请一示例性实施例示出的一种急停单元的结构示意图；5 is a schematic structural diagram of an emergency stop unit shown in an exemplary embodiment of the present application;

图6是本申请一示例性实施例示出的又一种脉冲产生电路的结构示意图；FIG. 6 is a schematic structural diagram of another pulse generating circuit shown in an exemplary embodiment of the present application;

图7是本申请一示例性实施例示出的一种肿瘤治疗装置的结构示意图。FIG. 7 is a schematic structural diagram of a tumor treatment device according to an exemplary embodiment of the present application.

具体实施方式Detailed ways

这里将详细地对示例性实施例进行说明，其示例表示在附图中。下面的描述涉及附图时，除非另有表示，不同附图中的相同数字表示相同或相似的要素。以下示例性实施例中所描述的实施方式并不代表与本申请相一致的所有实施方式。相反，它们仅是与如所附权利要求书中所详述的、本申请的一些方面相一致的装置和方法的例子。Exemplary embodiments will be described in detail herein, examples of which are illustrated in the accompanying drawings. Where the following description refers to the drawings, the same numerals in different drawings refer to the same or similar elements unless otherwise indicated. The implementations described in the illustrative examples below are not intended to represent all implementations consistent with this application. Rather, they are merely examples of apparatus and methods consistent with some aspects of the present application as recited in the appended claims.

在本申请使用的术语是仅仅出于描述特定实施例的目的，而非旨在限制本申请。在本申请和所附权利要求书中所使用的单数形式的“一种”、“所述”和“该”也旨在包括多数形式，除非上下文清楚地表示其他含义。The terminology used in this application is for the purpose of describing particular embodiments only and is not intended to limit the application. As used in this application and the appended claims, the singular forms "a," "the," and "the" are intended to include the plural forms as well, unless the context clearly dictates otherwise.

应当理解，尽管在本申请可能采用术语第一、第二、第三等来描述各种信息，但这些信息不应限于这些术语。这些术语仅用来将同一类型的信息彼此区分开。例如，在不脱离本申请范围的情况下，第一信息也可以被称为第二信息，类似地，第二信息也可以被称为第一信息。取决于语境，如在此所使用的词语“如果”可以被解释成为“在……时”或“当……时”或“响应于确定”。It should be understood that although the terms first, second, third, etc. may be used in this application to describe various information, such information should not be limited by these terms. These terms are only used to distinguish the same type of information from each other. For example, the first information may also be referred to as the second information, and similarly, the second information may also be referred to as the first information without departing from the scope of the present application. Depending on the context, the word "if" as used herein can be interpreted as "at the time of" or "when" or "in response to determining."

图1所示为一个实施例的脉冲产生电路10的示意图。脉冲产生电路10应用于包含电极针的肿瘤治疗装置。脉冲产生电路10包括主控制板1、RS485接口芯片2、电源单元3、脉冲产生单元4以及切换单元5。脉冲产生单元4配置有第一处理器41，切换单元5配置有第二处理器51。主控制板1的第一UART口11连接RS485接口芯片2的输入端，RS485接口芯片2的输出端通过RS485总线分别连接第一处理器41和第二处理器51；主控制板1的第二UART口12连接电源单元3的输入端，用于控制电源单元3产生高压直流电压，并输出至脉冲产生单元4；脉冲产生单元4的输入端连接电源单元3的输出端，脉冲产生单元4响应于第一处理器41，用于接收高压直流电压，并将高压直流电压转变成双极性脉冲电压，以及将双极性脉冲电压输出至切换单元5；切换单元5的输入端连接脉冲产生单元4的输出端，切换单元5响应于第二处理器51，用于接收双极性脉冲电压，并将双极性脉冲电压输出至对应的电极针20。FIG. 1 is a schematic diagram of apulse generating circuit 10 according to an embodiment. Thepulse generating circuit 10 is applied to a tumor treatment device including an electrode needle. Thepulse generating circuit 10 includes a main control board 1 , an RS485 interface chip 2 , apower supply unit 3 , apulse generating unit 4 and aswitching unit 5 . Thepulse generating unit 4 is configured with afirst processor 41 , and theswitching unit 5 is configured with asecond processor 51 . Thefirst UART port 11 of the main control board 1 is connected to the input end of the RS485 interface chip 2, and the output end of the RS485 interface chip 2 is respectively connected to thefirst processor 41 and thesecond processor 51 through the RS485 bus; The UARTport 12 is connected to the input end of thepower supply unit 3, and is used to control thepower supply unit 3 to generate a high-voltage DC voltage and output it to thepulse generation unit 4; the input end of thepulse generation unit 4 is connected to the output end of thepower supply unit 3, and thepulse generation unit 4 responds Thefirst processor 41 is used for receiving the high voltage DC voltage, converting the high voltage DC voltage into a bipolar pulse voltage, and outputting the bipolar pulse voltage to theswitching unit 5; the input end of theswitching unit 5 is connected to the pulse generating unit At the output end of 4 , theswitching unit 5 is responsive to thesecond processor 51 for receiving the bipolar pulse voltage and outputting the bipolar pulse voltage to thecorresponding electrode needle 20 .

具体的说，本申请实施例中，主控制板1至少部分以数字电子电路、模拟电子电路或者计算机硬件、固件、软件或其组合来实现。在一可选的实施例中，主控制板1的功能可以由单片机来完成，可选的，可以由STM32F2系列芯片搭建而成，比如型号为STM32F207VCT6的芯片。STM32F2系列单片机搭载ARM Cortex-M3内核，能够自适应实时闪存加速器使得STM32F2可以在片内闪存上以120MHz的高速零等待地执行代码，从而可以最大化地发挥ARMCortex-M3内核的性能优势。Specifically, in the embodiments of the present application, the main control board 1 is at least partially implemented by digital electronic circuits, analog electronic circuits, or computer hardware, firmware, software, or a combination thereof. In an optional embodiment, the function of the main control board 1 may be performed by a single chip microcomputer, or alternatively, it may be constructed by an STM32F2 series chip, such as a chip with a model of STM32F207VCT6. The STM32F2 series of microcontrollers are equipped with the ARM Cortex-M3 core, which can adapt to the real-time flash memory accelerator so that the STM32F2 can execute code on the on-chip flash memory at a high speed of 120MHz without waiting, thus maximizing the performance advantages of the ARM Cortex-M3 core.

本实施例中，主控制板1的第一UART口11和第二UART口12均采用TTL电平，即低电平(0V电平)为0，高电平(+5V电平)为1，以异步通信的方式传输数据。而RS485通信采用差分信号传输方式，也称作平衡传输，采用一对双绞线，将其中一线定义为A，另一线定义为B。逻辑“1”以两线间的电压差为+(2～6)V表示；逻辑“0”以两线间的电压差为-(2～6)V表示。RS485接口芯片2主要用于电平转换，将第一UART口11出来的信号转换成适用于RS485网络传输的数据。可选的，RS485接口芯片2可以采用SN65LBC176A系列芯片，该芯片采用平衡驱动器和差分接收器的组合，抗共模干扰能力增强，抗噪声干扰性好。In this embodiment, thefirst UART port 11 and thesecond UART port 12 of the main control board 1 both use TTL level, that is, the low level (0V level) is 0, and the high level (+5V level) is 1 , which transmits data in asynchronous communication. The RS485 communication adopts the differential signal transmission method, also known as balanced transmission, using a pair of twisted pairs, one of which is defined as A, and the other is defined as B. Logic "1" is represented by the voltage difference between the two lines as +(2~6)V; logic "0" is represented by the voltage difference between the two lines as -(2~6)V. The RS485 interface chip 2 is mainly used for level conversion, and converts the signal from thefirst UART port 11 into data suitable for RS485 network transmission. Optionally, the RS485 interface chip 2 can use the SN65LBC176A series chip, which adopts a combination of a balanced driver and a differential receiver, and has enhanced anti-common mode interference capability and good anti-noise interference.

本申请实施例中，RS485通信网络采用总线式拓扑结构，同一总线上最多可以挂接128个或者256个节点，最大的可以支持到400个节点。在本实施例中，主控制板1作为主功能板，脉冲产生单元4和切换单元5作为从功能板，主控制板1通过RS485串行总线与各从功能板(脉冲产生单元4和切换单元5)连接，从而控制各从功能板协同工作。每个从功能板都单独配置有处理器，使得各从功能板可以独立工作。在一可选实施例中，第一处理器41和第二处理器51均可采用ARM Cortex-M3处理器进行逻辑控制与电流电压信号采集，并将采集的电流电压信号通过RS485网络反馈给主控制板1。以供主控制板1收集各从功能板的工作状态、电流电压参数等。In the embodiment of the present application, the RS485 communication network adopts a bus topology structure, and a maximum of 128 or 256 nodes can be connected to the same bus, and a maximum of 400 nodes can be supported. In this embodiment, the main control board 1 is used as the main function board, thepulse generation unit 4 and theswitch unit 5 are used as the slave function boards, and the main control board 1 communicates with each of the slave function boards (thepulse generation unit 4 and the switch unit) through the RS485 serial bus. 5) Connect to control each slave function board to work together. Each slave function board is individually configured with a processor, so that each slave function board can work independently. In an optional embodiment, both thefirst processor 41 and thesecond processor 51 can use an ARM Cortex-M3 processor to perform logic control and current and voltage signal acquisition, and feed back the collected current and voltage signals to the host through the RS485 network. Control Board 1. For the main control board 1 to collect the working status, current and voltage parameters of each slave function board.

在一可选的实施例中，主控制板1可以通过RS232串行线连接电源单元3。具体的，主控制板1的第二UART口12可以通过RS232接口芯片6连接至电源单元3，参考图1。RS232接口芯片6主要用于电平转换，以使得第二UART口12出来的信号可以通过RS232串行线传输。当然，主控制板1也可以通过其它的连接方式连接电源单元3。In an optional embodiment, the main control board 1 can be connected to thepower supply unit 3 through an RS232 serial line. Specifically, thesecond UART port 12 of the main control board 1 can be connected to thepower supply unit 3 through theRS232 interface chip 6 , referring to FIG. 1 . TheRS232 interface chip 6 is mainly used for level conversion, so that the signal from thesecond UART port 12 can be transmitted through the RS232 serial line. Of course, the main control board 1 can also be connected to thepower supply unit 3 through other connection methods.

本申请实施例中的电源单元3用来为脉冲产生电路10的各个单元供电。电源单元3可包括，例如，市电电源、总开关、电源滤波装置、开关电源模块和高压直流电源模块。其中，开关电源模块可包括变压和整流装置，例如，将220V/50Hz交流输入变为12V直流输出。高压直流电源模块可以基于主控制板1的命令生成所需的高压直流电压。例如，将220V的交流市电电压转换生成为800V至3000V的直流电压。在另一些示例中，高压直流电源模块也可以将交流市电电压转换生成为诸如300V、400V、500V、600V或700V之类的低于800V的直流电压。Thepower supply unit 3 in the embodiment of the present application is used to supply power to each unit of thepulse generating circuit 10 . Thepower supply unit 3 may include, for example, a mains power supply, a main switch, a power supply filtering device, a switching power supply module and a high voltage DC power supply module. Wherein, the switching power supply module may include a voltage transformer and a rectifier device, for example, to convert a 220V/50Hz AC input into a 12V DC output. The high-voltage DC power module can generate the required high-voltage DC voltage based on the command of the main control board 1 . For example, the AC mains voltage of 220V is converted into a DC voltage of 800V to 3000V. In other examples, the high voltage DC power module may also convert the AC mains voltage to a DC voltage below 800V, such as 300V, 400V, 500V, 600V or 700V.

本申请实施例中的脉冲产生单元4基于第一处理器41的指令，从电源单元3接收高压直流电压，并将该高压直流电压转变成双极性脉冲电压(包括正极性脉冲电压和负极性脉冲电压)。在一个实施例中，脉冲产生单元4可以为IGBT全桥电路，如图2所示。脉冲产生单元4接收的高压直流电压经过电流传感器42进行电流采样，然后经过ADC模数转换器43进行转换，然后通过IGBT全桥电路转换成双极性脉冲电压输出至切换单元5。在一可选的实施例中，脉冲产生单元4还可以包括脚踏开关S1，脚踏开关S1连接于脉冲产生单元4的输出端和转换单元5的输入端之间，可以更加方便的切断或导通双极性脉冲电压的输出。Thepulse generating unit 4 in the embodiment of the present application receives the high voltage DC voltage from thepower supply unit 3 based on the instruction of thefirst processor 41, and converts the high voltage DC voltage into a bipolar pulse voltage (including a positive polarity pulse voltage and a negative polarity pulse voltage). pulse voltage). In one embodiment, thepulse generating unit 4 may be an IGBT full-bridge circuit, as shown in FIG. 2 . The high voltage DC voltage received by thepulse generation unit 4 is sampled by thecurrent sensor 42 , then converted by the ADC analog-to-digital converter 43 , and then converted into a bipolar pulse voltage by the IGBT full-bridge circuit and output to theswitching unit 5 . In an optional embodiment, thepulse generating unit 4 may also include a foot switch S1, and the foot switch S1 is connected between the output end of thepulse generating unit 4 and the input end of the convertingunit 5, which can be more convenient to cut off or The output of the bipolar pulse voltage is turned on.

在一可选的实施例中，切换单元5包含至少2个切换通道，每个切换通道包含一个单刀双掷开关52和一个单刀单掷开关53。请参考图3(图3中以2个切换通道为例进行说明)。在一可选的实施例中，单刀双掷开关52和单刀单掷开关53均为继电器开关。单刀双掷开关52的两个不动端分别连接脉冲产生单元4输出的双极性脉冲电压的正极性脉冲电压端和负极性脉冲电压端。单刀双掷开关52的公共端通过单刀单掷开关53连接至电极针20。其中，单刀双掷开关52和单刀单掷开关53的使能端均连接至第二处理器51，单刀双掷开关52用来进行脉冲电压极性的选择，单刀单掷开关53用来控制脉冲的输出。在本实施例中，该切换通道中至少有2个切换通道同时导通，即：其中一个切换通道输出正极性脉冲电压，另一个输出负极性脉冲电压。同理，本实施例中的电极针20也至少有2个，其中一个输出正极性脉冲电压，另一个输出负极性脉冲电压。电极针20被用于施加到人体的肿瘤组织，从而在肿瘤组织上的电极针20之间形成高压电场。In an optional embodiment, theswitching unit 5 includes at least two switching channels, and each switching channel includes a single-pole double-throw switch 52 and a single-pole single-throw switch 53 . Please refer to FIG. 3 (in FIG. 3 , two switching channels are used as an example for description). In an optional embodiment, both theSPDT switch 52 and theSPST switch 53 are relay switches. The two stationary terminals of theSPDT switch 52 are respectively connected to the positive polarity pulse voltage terminal and the negative polarity pulse voltage terminal of the bipolar pulse voltage output by thepulse generating unit 4 . The common terminal of theSPDT switch 52 is connected to theelectrode needle 20 through theSPDT switch 53 . The enabling terminals of theSPDT switch 52 and theSPDT switch 53 are both connected to thesecond processor 51, theSPDT switch 52 is used to select the polarity of the pulse voltage, and theSPDT switch 53 is used to control the pulse voltage Output. In this embodiment, at least two of the switching channels are turned on at the same time, that is, one of the switching channels outputs a positive-polarity pulse voltage, and the other outputs a negative-polarity pulse voltage. Similarly, there are at least two electrode needles 20 in this embodiment, one of which outputs a positive-polarity pulse voltage, and the other outputs a negative-polarity pulse voltage. The electrode needles 20 are used to be applied to the tumor tissue of the human body, thereby forming a high-voltage electric field between the electrode needles 20 on the tumor tissue.

可选的，本实施例中的切换通道有8个，每个切换通道的输出端连接一个电极针20。基于所针对的肿瘤类型、形状、尺寸、恶性程度等因素，可以选择更多的电极针20。例如可以选择8个电极针20，其中4个输出正极性脉冲电压，另外4个输出负极性脉冲电压。在另一示例中，可以选择4个、5个或7个电极针20，并且所选的电极针20输出的脉冲电压的极性不同。Optionally, there are 8 switching channels in this embodiment, and the output end of each switching channel is connected to anelectrode needle 20 . More electrode needles 20 may be selected based on the targeted tumor type, shape, size, degree of malignancy and other factors. For example, 8 electrode needles 20 can be selected, among which 4 output pulse voltage of positive polarity, and the other 4 output pulse voltage of negative polarity. In another example, 4, 5 or 7 electrode needles 20 may be selected, and the polarity of the pulse voltage output by the selected electrode needles 20 is different.

在本实施例中，在使用单刀双掷开关52进行脉冲电压极性的选择时，要么选择正极性脉冲电压，要么选择负极性脉冲电压，不会出现正极负极脉冲电压同时导通的现象，从而可以避免输出短路。In this embodiment, when using theSPDT switch 52 to select the polarity of the pulse voltage, either the positive pulse voltage or the negative pulse voltage is selected, and the phenomenon that the positive and negative pulse voltages are turned on at the same time will not occur, so that Output short circuit can be avoided.

在另一可选的实施例中，参考图4，脉冲产生电路10还可以包括急停单元7，急停单元7连接在电源单元3和脉冲产生单元4之间，急停单元7包括第三处理器71和急停开关72。RS485接口芯片2的输出端通过RS485总线连接第三处理器71；第三处理器71也可以采用ARMCortex-M3进行逻辑控制与电流电压信号采集，并将采集的电流电压信号通过RS485网络反馈给主控制板1。In another optional embodiment, referring to FIG. 4 , thepulse generating circuit 10 may further include anemergency stop unit 7, theemergency stop unit 7 is connected between thepower supply unit 3 and thepulse generating unit 4, and theemergency stop unit 7 includes athird Processor 71 andemergency stop switch 72 . The output end of the RS485 interface chip 2 is connected to thethird processor 71 through the RS485 bus; thethird processor 71 can also use ARM Cortex-M3 to perform logic control and current and voltage signal acquisition, and feed back the collected current and voltage signals to the host through the RS485 network. Control Board 1.

在一可选的实施例中，急停单元7还可以包括开关K1、开关K2、电容C1、放电开关K3、放电电阻R1、分压电阻R2和分压电阻R3。如图5所示。电容C1并联在电源单元3的高压直流电源模块的输出端，进行电能的存储，急停单元7响应于第三处理器71，在急停开关72被导通时(例如机械按钮被按下)，通过断开开关K1切断从电源单元3接收高压直流电压的能量输入，通过断开开关K2切断向脉冲产生单元4输出高压直流电压的能量输出，通过闭合放电开关K3，接通放电电阻R1将电容C1存储的能量释放，从而达到降压、放电的目的。另外，分压电阻R2和分压电阻R3可以将高电压分压成低电压输入到第三处理器71，以供第三处理器71进行电流电压信号的采集。In an optional embodiment, theemergency stop unit 7 may further include a switch K1, a switch K2, a capacitor C1, a discharge switch K3, a discharge resistor R1, a voltage dividing resistor R2 and a voltage dividing resistor R3. As shown in Figure 5. The capacitor C1 is connected in parallel with the output end of the high voltage DC power supply module of thepower supply unit 3 to store electric energy. Theemergency stop unit 7 responds to thethird processor 71 when theemergency stop switch 72 is turned on (for example, the mechanical button is pressed) , by turning off the switch K1 to cut off the energy input of the high-voltage DC voltage received from thepower supply unit 3, by turning off the switch K2 to cut off the energy output of the high-voltage DC voltage to thepulse generating unit 4, by closing the discharge switch K3, turning on the discharge resistor R1 to The energy stored in the capacitor C1 is released, so as to achieve the purpose of voltage reduction and discharge. In addition, the voltage dividing resistor R2 and the voltage dividing resistor R3 can divide the high voltage into a low voltage and input it to thethird processor 71 for thethird processor 71 to collect current and voltage signals.

在另一可选的实施例中，如图6中所示，脉冲产生电路10还可以包括第一隔离单元8，第一隔离单元8连接在第一UART口11与RS485接口芯片2的输入端之间。在另一可选的实施例中，脉冲产生电路10还可以包括第二隔离单元9，继续参考图6，第二隔离单元9连接在第二UART口12与电源单元3的输入端之间。第一隔离单元8和第二隔离单元9均可以包括隔离变压器和光电隔离器，隔离变压器主要用于电气隔离，使得一次侧与二次侧的控制电路不被干扰。光电隔离器将接收到的信号进行电-光-电的转换，在转换过程中把电路中的干扰源和易受干扰的部分隔离开来，起到输入、输出、隔离的作用，从而可以避免信号之间的干扰以及隔离保障设备及操作人员的安全。In another optional embodiment, as shown in FIG. 6 , thepulse generating circuit 10 may further include afirst isolation unit 8 , and thefirst isolation unit 8 is connected to thefirst UART port 11 and the input end of the RS485 interface chip 2 between. In another optional embodiment, thepulse generating circuit 10 may further include asecond isolation unit 9 . With continued reference to FIG. 6 , thesecond isolation unit 9 is connected between thesecond UART port 12 and the input terminal of thepower supply unit 3 . Both thefirst isolation unit 8 and thesecond isolation unit 9 may include an isolation transformer and an optoelectronic isolator. The isolation transformer is mainly used for electrical isolation, so that the control circuits of the primary side and the secondary side are not disturbed. The optoelectronic isolator converts the received signal into electrical-optical-electrical, isolates the interference source in the circuit and the susceptible part during the conversion process, and plays the role of input, output and isolation, so as to avoid Interference and isolation between signals ensure the safety of equipment and operators.

本申请实施例的脉冲产生电路10采用RS485主从网络的拓扑结构，主控制板1通过RS485串行总线与其他从功能板(脉冲产生单元4和切换单元5以及急停单元7)连接。而且每个从功能板都单独配置有处理器，可以独立工作，主控制板1又可以通过RS485网络控制各从功能板协同工作。相对于现有技术中主控板通过IO口并发控制其它功能板块，减少了连接接口，布线简单，大大简化了各板块之间的连接结构。而且RS485接口采用差分方式传输信号，相较于现有技术中IO口的并发控制，提高了抗干扰能力，能有效提升响应速度。另外，在需要添加新的从功能板时，直接串接到RS485总线上即可，简单方便。在故障维修时，可以只对有故障的功能板进行维修，有利于系统维护。Thepulse generating circuit 10 of the embodiment of the present application adopts the RS485 master-slave network topology, and the master control board 1 is connected to other slave function boards (pulse generating unit 4, switchingunit 5 and emergency stop unit 7) through the RS485 serial bus. Moreover, each slave function board is individually configured with a processor, which can work independently, and the main control board 1 can control the slave function boards to work together through the RS485 network. Compared with the prior art, the main control board concurrently controls other functional blocks through the IO port, which reduces the number of connection interfaces, the wiring is simple, and the connection structure between the blocks is greatly simplified. Moreover, the RS485 interface uses differential mode to transmit signals. Compared with the concurrent control of the IO port in the prior art, the anti-interference ability is improved, and the response speed can be effectively improved. In addition, when a new slave function board needs to be added, it can be directly connected to the RS485 bus, which is simple and convenient. During fault maintenance, only the faulty function board can be repaired, which is beneficial to system maintenance.

图7所示为一个实施例的肿瘤治疗装置的结构示意图。肿瘤治疗装置包括：至少2个电极针20、上位机30以及上述的脉冲产生电路10。其中，上位机30通过串口连接主控制板1，例如，可以选择RS485串口连接控制板1，电极针20连接脉冲产生电路10中切换单元5的输出端。FIG. 7 is a schematic structural diagram of a tumor treatment device according to an embodiment. The tumor treatment device includes: at least two electrode needles 20 , ahost computer 30 and the above-mentionedpulse generating circuit 10 . Thehost computer 30 is connected to the main control board 1 through a serial port. For example, an RS485 serial port can be selected to connect to the control board 1 , and theelectrode needle 20 is connected to the output end of theswitching unit 5 in thepulse generating circuit 10 .

电极针20具体连接在切换单元5中每个切换通道的输出端。可选的，电极针20的数量为8个，切换单元5中切换通道也为8个，每个电极针20连接一个切换通道。Theelectrode needle 20 is specifically connected to the output end of each switching channel in theswitching unit 5 . Optionally, the number of electrode needles 20 is 8, the number of switching channels in theswitching unit 5 is also 8, and eachelectrode needle 20 is connected to one switching channel.

电极针20用于被施加到人体的肿瘤组织，从而在肿瘤组织上的电极针20之间形成高压电场，该高压电场对肿瘤细胞造成不可逆的伤害，从而使得肿瘤细胞自然凋亡，以此达到肿瘤治疗的目的。8个电极针可以适用于更多的肿瘤类型、形状及尺寸等，以提供更多的治疗方式，提高产品竞争力。The electrode needles 20 are used to be applied to the tumor tissue of the human body, so that a high-voltage electric field is formed between the electrode needles 20 on the tumor tissue. The purpose of tumor treatment. 8 electrode needles can be applied to more tumor types, shapes and sizes, etc., to provide more treatment methods and improve product competitiveness.

本申请实施例中，上位机30可以是诸如计算机和平板电脑之类的计算设备。在一些示例中，上位机30可以包括各种输入/输出设备。例如，输入设备可以为触摸屏、小键盘或全键盘等。输出设备可以为各种视觉、听觉、触觉输出设备，例如，显示器、LED灯、振动器等。上位机30用于接收治疗参数(如患者的基本信息和消融参数等)、传递控制参数、获取状态信息，监控治疗过程，显示治疗结果以及输出治疗报告等。In this embodiment of the present application, thehost computer 30 may be a computing device such as a computer and a tablet computer. In some examples, thehost computer 30 may include various input/output devices. For example, the input device may be a touch screen, a keypad or a full keyboard, or the like. The output devices may be various visual, auditory, tactile output devices, eg, displays, LED lights, vibrators, and the like. Thehost computer 30 is used for receiving treatment parameters (such as the basic information of the patient and ablation parameters, etc.), transmitting control parameters, acquiring status information, monitoring the treatment process, displaying treatment results, and outputting treatment reports.

以上所述仅为本申请的较佳实施例而已，并不用以限制本申请，凡在本申请的精神和原则之内，所做的任何修改、等同替换、改进等，均应包含在本申请保护的范围之内。The above descriptions are only preferred embodiments of the present application, and are not intended to limit the present application. Any modifications, equivalent replacements, improvements, etc. made within the spirit and principles of the present application shall be included in the present application. within the scope of protection.