CN110680343A - Novel subcutaneous glucose sensor circuit conduction method - Google Patents

Abstract

The invention relates to a novel subcutaneous glucose sensor and a circuit conduction method thereof, belonging to the technical field of glucose biosensors. The draw-in groove of data collection station shell and the buckle chucking of sensor base, the last contact post of data collection station compresses tightly with the corresponding conductive pillar of sensor, and the contact post with lead electrical pillar intercommunication, contact post, lead electrical pillar, electrode can form the current loop that switches on. The data collector applies specific voltages to different electrodes through the contact posts and detects the current in the loop. The method has the advantages of simple structure, good reliability, short working time and convenience for batch production, ensures the stability and reliability of the circuit and improves the accuracy of blood sugar measurement.

Description

Novel subcutaneous glucose sensor circuit conduction method

Technical Field

The invention relates to the technical field of glucose biosensors, in particular to a novel subcutaneous glucose sensor and a circuit conduction method thereof.

Background

Diabetes is a common endocrine-metabolic disease that seriously harms human health worldwide. In recent years, the global diabetes prevalence rate shows a remarkable rising trend. For diabetic patients, blood sugar monitoring is very important, and a corresponding treatment scheme must be established according to the blood sugar level. The dynamic blood sugar atlas of the patient can be obtained by continuous blood sugar monitoring, the change rule of the blood sugar of the patient can be accurately mastered, then a more effective treatment scheme is made in a targeted manner, and the treatment effect is greatly improved. In recent years, various companies at home and abroad research and develop biosensors capable of continuously measuring blood sugar, the biosensors are generally embedded in subcutaneous tissues, and the blood sugar is monitored by continuously measuring interstitial fluid glucose.

Most of the biosensors currently used for continuous glucose monitoring use glucose oxidase, which is characterized by high selectivity for glucose. Considering the implantation feasibility and the working stability, the size of the subcutaneously implanted sensor is required to be as small as possible, so that the pain feeling is small when the sensor is implanted, the rejection reaction of a human body caused after the sensor is implanted is also small, and the normal work of the sensor is facilitated.

The current glucose biosensor used for subcutaneous implantation has two types, one type is the sensor is implanted to the needs guide pin, and the substrate generally is flexible macromolecular material, because the substrate does not have mechanical strength, needs the guide pin just can realize implanting. The sensor has the advantages of complex structure, larger volume, stronger pain sense in the implantation process, very limited effective sensing area and low signal-to-noise ratio.

The other type is a sensor implanted without a guide pin, the base material is generally metal, and the base material has better mechanical strength, so that the implantation can be realized without the guide pin. The sensor has small volume, the effective area of the electrode is improved, but the production and assembly process flow is complex, and the realization of large-scale industrial production is difficult.

All biosensors need to consider the problem of circuit conduction, need to design a relatively complex circuit structure and adopt a micro-plugging structure, and the reliability of the structures is often poor, and the problem of disconnection caused by the fault of a lead or a connector can occur, so that the biosensors can not work normally. Especially for metal electrodes, the conduction of the metal electrodes is a difficult problem, the metal electrodes generally have biological enzymes, cannot bear high temperature, cannot adopt conventional welding means, and adopt conductive adhesive, so that the working time is long, the process is complex and the reliability is poor.

Disclosure of Invention

The invention mainly solves the problems of low working efficiency, complex structure, poor reliability and difficult batch production in the prior art, and provides a novel method for conducting a circuit between a subcutaneous glucose sensor and a data acquisition unit.

The technical problem of the invention is mainly solved by the following technical scheme:

the invention mainly solves the problem of circuit conduction between a subcutaneous glucose sensor and a data acquisition unit. The data collector is provided with a conductive contact column, the upper end of the contact column is connected with the circuit board of the data collector, the lower end of the contact column is exposed on the shell, and the data collector can provide constant voltage to the outside through the contact column.

The sensor electrode is arranged in the fixing cap, the fixing cap is an injection molding part, a through hole is formed in the fixing cap, the sensor electrode is mainly fixed, the electrode is fixed in the fixing cap through a tool, the head part and the tail part of the electrode are exposed to a certain length, and the head part is exposed to a length no more than 5 mm. The fixed cap (with electrode) can be embedded in the through hole of the sensor base in a clamping manner, the head of the electrode faces downwards, the conductive column is pressed into the through hole from the upper side of the sensor base, the tail of the electrode is matched with the tail of the conductive column, the electrode and the conductive column are in a communicated state, and the upper end of the conductive column is exposed to a certain height.

In order to be connected and fixed with the sensor conveniently, a clamping groove is designed at the edge of the shell of the data acquisition unit, and a fastener is arranged on the base of the sensor. After the clamping groove of the data acquisition unit is fastened with the buckle of the sensor base, the contact column of the data acquisition unit and the conductive column of the glucose sensor are respectively and correspondingly compressed, so that the circuit board, the contact column, the conductive column and the electrode circuit are communicated.

After the glucose sensor is implanted into a human body, the plurality of electrodes intervene subcutaneous tissues, the data acquisition unit provides constant voltage for the corresponding electrodes through the contact columns, and simultaneously detects the current value of a loop between the electrodes, wherein the current value is related to the glucose concentration of tissue fluid. The data acquisition unit stores and analyzes the detected current value, and then sends the current value to a display device (such as a smart phone).

The data acquisition unit comprises shell, MCU and circuit board, battery etc. and the data acquisition unit bottom is equipped with a plurality of contact posts, and the contact post passes through circuit board and power intercommunication. The contact post material is preferably metal material, and can also be conductive non-metal material, and the position and the size of contact post correspond with the through-hole of placing conductive pillar on the sensor base.

The conductive column is made of a nonmetal conductive elastic material, such as conductive silica gel, or an elastic thimble made of a metal material.

The number of the contact posts is three or more, the contact posts are made of metal materials, and the contact posts can be conducted with the circuit board through a welding method.

The number of the sensor electrodes is two or more, and the base material is made of metal materials and comprises an inert metal layer, a catalyst layer, an enzyme layer, a macromolecule layer and the like.

Preferably, the data collector adopts a rechargeable battery, and two of the contact posts at the bottom of the shell are communicated with the charger to charge the battery.

Compared with the prior art, the circuit conduction method of the novel subcutaneous glucose sensor has the advantages of stability, reliability, simple structure, high production efficiency and convenience in batch production.

Drawings

Fig. 1 is an exploded view of the structure of the present invention.

Fig. 2 is a structural sectional view of the present invention.

FIG. 3 is an exploded view of the structure of a glucose sensing assembly of the present invention.

In the figure: glucose sensor 1, data acquisition subassembly 2, data collection ware 3, circuit board 4, contact post 5, lead electrical pillar 6, locking cap 7, electrode 8, sensor base 9.

Detailed Description

The technical scheme of the invention is further specifically described by the following embodiments and the accompanying drawings.

Example 1: as shown in fig. 1-3, a novel subcutaneous glucose sensor circuit conduction method is as follows:

the data collector 3 is composed of a shell, an MCU singlechip, a PCB circuit board, a rechargeable battery and other parts. The shell of the data collector 3 can be manufactured in an injection molding or glue filling one-step forming mode, the circuit board 4, the battery and the contact column 5 are fixedly assembled inside the shell, and only the lower end of the contact column 5 is exposed on the shell.

The sensor electrode 8 is arranged in the fixing cap 7, the fixing cap 7 is an injection molding part, a through hole is formed in the fixing cap, and the fixing cap is mainly used for fixing the electrode 8. The head and the tail of the electrode 8 are exposed to a certain length, the head is exposed to 5mm, the tail is exposed to more than 1mm, then the fixing cap 7 with the electrode 8 is embedded into the through hole of the sensor base 9, the head of the electrode 8 faces downwards, the conductive column 6 is pressed into the through hole of the sensor base 9 from the upper side of the sensor base 9, the tail of the electrode 8 is matched with the tail of the conductive column 6, and the electrode 8 and the conductive column 6 are in a communicated state. The conductive column 6 is made of conductive silica gel, and the upper end of the conductive column is exposed out of the plane of the sensor base 9 by a certain height.

After the clamping groove of the data acquisition unit 3 and the buckle of the sensor base 9 are fastened, the contact column 5 and the conductive column 6 are correspondingly pressed, so that the circuit board 4, the contact column 5, the conductive column 6 and the electrode 8 are communicated with each other in a circuit mode.

After the glucose sensor 1 is implanted into a human body, a plurality of electrodes 8 intervene in subcutaneous tissues, the data acquisition unit 2 provides constant voltage for the electrodes 8 through the contact posts 5, and simultaneously detects the current value of a loop between the electrodes 8.

There are five data acquisition device 3 shell bottom contact posts, and three are used for connecting the sensor electrode, and two can communicate with the charger in addition, realize charging to the battery.

The sensor electrode 8 has three electrode substrates made of metal, the substrate is made of metal, and the electrode function layer comprises an inert metal layer, a catalyst layer, an enzyme layer, a polymer layer and the like.

During the use, implant subcutaneous tissue through the implanter with glucose sensor 1 earlier, then with data collection station 2 and 1 pressfitting of glucose sensor, make the draw-in groove of 3 shells of data collection station and the buckle chucking of sensor base 9, the contact post 5 on the data collection station 3 compresses tightly with the corresponding outstanding electric conduction post 6 of sensor base 9 respectively, contact post 5 with lead electric conduction post 6 intercommunication, contact post 5, lead electric conduction post 6, electrode 8 formation switched on current return circuit.

The data collector 3 supplies a constant voltage to the electrodes 8 through the contact posts 5 while detecting the current value of the circuit between the electrodes, which is related to the interstitial fluid glucose concentration. The data acquisition unit stores and analyzes the detected current value, and then sends the current value to other receiving equipment (such as a smart phone) in a wireless transmission mode.

In conclusion, the invention provides the circuit conduction method of the novel subcutaneous glucose sensor, and the method has the advantages of simple structure, good reliability, short working time and convenience for batch production, ensures the stability and reliability of the circuit and improves the accuracy of blood glucose measurement.

The above description is only an embodiment of the present invention, but the structural features of the present invention are not limited thereto, and any changes or modifications within the scope of the present invention by those skilled in the art are covered by the present invention.

Claims (7)

1. A novel subcutaneous glucose sensor circuit conduction method is characterized in that: the bottom of the data collector (3) is provided with a conductive contact column (5), the contact column (5) is communicated with the data collector circuit board (4), and the data collector (3) can provide constant voltage outwards according to setting through the contact column (5);

the sensor electrode (8) is arranged in the fixed cap (7), then the fixed cap (7) and the electrode are embedded into the through hole of the sensor base (9), the head of the electrode (8) faces downwards, the conductive column (6) is pressed into the through hole of the sensor base (9) from the upper part of the sensor base (9), so that the tail part of the electrode (8) is matched with the tail part of the conductive column (6), and the electrode (8) and the conductive column (6) are in a communicated state;

after the clamping groove of the data collector (3) is fastened with the buckle of the sensor base (9), the contact post (5) of the data collector (3) and the conductive post (6) of the glucose sensor (1) are respectively and correspondingly pressed, so that the circuit board (4), the contact post (5), the conductive post (6) and the electrode (8) are in circuit communication;

after the glucose sensor (1) is implanted into a human body, a plurality of electrodes (8) intervene subcutaneous tissues, the data collector (3) provides constant voltage for the corresponding electrodes (8) through the contact posts (5), and meanwhile, the current value of a loop between the electrodes (8) is detected.

2. The novel subcutaneous glucose sensor circuit conduction method according to claim 1, characterized in that: the data acquisition unit (3) is composed of an MCU singlechip, a circuit board (4) and a rechargeable battery.

3. The novel subcutaneous glucose sensor circuit conduction method according to claim 2, characterized in that: the circuit board (4) is communicated with an external power supply through the contact posts (5), so that the battery is charged.

4. The novel subcutaneous glucose sensor circuit conduction method according to claim 1, characterized in that: electrode (8) are fixed in fixed cap (7) through the frock, and electrode (8) head and afterbody all expose certain length, lead electrical pillar (6) and press in the through-hole of sensor base (9) after, lead electrical pillar (6) upper end and expose certain height.

5. The novel subcutaneous glucose sensor circuit conduction method according to claim 1, characterized in that: the conductive column (6) can be made of nonmetal conductive elastic materials, such as conductive silica gel and the like, and can also be made of an elastic thimble made of metal materials.

6. The novel subcutaneous glucose sensor circuit conduction method according to claim 1, characterized in that: the electrode base material of the electrode (8) is made of metal materials, and an inert metal layer, a catalyst layer, an enzyme layer, a macromolecule layer and the like are sequentially arranged from inside to outside.

7. The novel subcutaneous glucose sensor circuit conduction method according to claim 1, characterized in that: the fixing cap (7) is an injection molding part, is internally provided with a through hole and mainly used for fixing the electrode (8).

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