技术领域technical field
本发明涉及一种基于NFC的连续血糖检测仪及检测方法，其属于医疗监测设备领域。The invention relates to an NFC-based continuous blood glucose detector and a detection method, which belong to the field of medical monitoring equipment.
背景技术Background technique
根据最新发布的第八版糖尿病地图，报告显示，截止至2017年，全球约4.25亿成人患糖尿病，占总人口的8.8%，预计到2045年，糖尿病患者可能达到6.29亿。糖尿病的治疗方法主要是对病人体内的葡萄糖代谢进行监控，医师根据血液中的葡萄糖含量给出治疗方法和生活作息，使血糖得到有效控制。According to the newly released eighth edition of the Diabetes Map, the report shows that as of 2017, about 425 million adults worldwide had diabetes, accounting for 8.8% of the total population. It is estimated that by 2045, the number of diabetic patients may reach 629 million. The treatment method of diabetes is mainly to monitor the glucose metabolism in the patient's body. The doctor gives the treatment method and daily routine according to the glucose content in the blood, so that the blood sugar can be effectively controlled.
过去临床血糖监测方法通常为有创监测，操作过程繁琐，并需要专业的医护人员读取数据。因此，近年来发展出一种无创血糖监测产品，能够实现血糖浓度的动态、持续监测。例如，中国发明专利申请“一种智能监测戒指式可穿戴设备”（申请专利号CN 105596010A，申请公报日2016.02.25）公开了一种智能监测戒指式可穿戴设备，其将基于动态光谱的无创血液成分检测技术所配套的检测设备设置在戒指中，分析出光谱数据通过无线传输方式向外发送，由智能终端接收数据，并从接收到的光谱数据分析出血糖浓度等监控数据。实现了智能无创人体血液实时及持续监测。基于光谱分析的无创血糖检测技术目前具有较低的灵敏度和准确性以及较低的葡萄糖特异性，因此主要出于实验室研究阶段。In the past, clinical blood glucose monitoring methods were usually invasive monitoring, the operation process was cumbersome, and professional medical staff needed to read the data. Therefore, in recent years, a non-invasive blood glucose monitoring product has been developed, which can realize dynamic and continuous monitoring of blood glucose concentration. For example, the Chinese invention patent application "An intelligent monitoring ring-type wearable device" (application patent number CN 105596010A, application bulletin date 2016.02.25) discloses an intelligent monitoring ring-type wearable device, which integrates non-invasive The detection equipment supporting the blood component detection technology is set in the ring, and the analyzed spectral data is sent out through wireless transmission, the data is received by the intelligent terminal, and monitoring data such as blood glucose concentration are analyzed from the received spectral data. Real-time and continuous monitoring of intelligent non-invasive human blood is realized. Spectral analysis-based non-invasive blood glucose detection technology currently has low sensitivity and accuracy and low glucose specificity, so it is mainly in the laboratory research stage.
随着无线通信技术的发展，使得便捷式的可穿戴连续血糖监测仪，借助于移动通信技术和智能移动终端式血糖的连续血糖称为可能。中国发明专利申请“一种手机APP直接监控的动态血糖监测仪及控制方法”（申请专利号CN108078569A,申请公布日2018.05.29）公开了一种手机APP直接监控的动态血糖监测仪及控制方法，包括可佩戴式血糖发射器，手机APP终端和通过手机APP终端连接的云端存储，血糖发射器通过无线发送方式将血糖监测数据发送给具有蓝牙收发功能的手机APP终端，进行数据显示分析，手机APP终端通过移动通讯网络连接到云端存储。血糖传感器基于双电极电流型传感器，由于传感器的阻抗随其结构而定，故电解反应产生电解电流时，给定电位发生变化。给定电位变化时，电极的电极反应就不会稳定，从而导致传感器的输出不稳定。With the development of wireless communication technology, a portable wearable continuous blood glucose monitor, with the help of mobile communication technology and intelligent mobile terminal blood glucose monitoring, is possible. The Chinese invention patent application "A dynamic blood glucose monitor and control method directly monitored by a mobile phone APP" (application patent number CN108078569A, application publication date 2018.05.29) discloses a dynamic blood glucose monitor and control method directly monitored by a mobile phone APP, Including a wearable blood glucose transmitter, a mobile APP terminal and cloud storage connected through the mobile APP terminal, the blood glucose transmitter sends the blood glucose monitoring data to the mobile APP terminal with Bluetooth transceiver function through wireless transmission, and performs data display and analysis. The mobile APP The terminal is connected to the cloud storage through the mobile communication network. The blood glucose sensor is based on a two-electrode amperometric sensor. Since the impedance of the sensor depends on its structure, when the electrolytic reaction generates an electrolytic current, the given potential changes. When a given potential changes, the electrode response of the electrode will not be stable, resulting in unstable sensor output.
中国发明专利申请“一种无线、实时血糖检测仪”（授权公告号CN204618248U，授权公告日2015.09.09）公开了一种无线、实时血糖监测仪，其主要由监测端和APP终端组成，所述的监测端包括葡萄糖感应探头和无线数据发射器；所述的无线数据发射器与葡萄糖感应探头连接，并将葡萄糖感应探头提供的血糖数据传值APP终端；所述的APP终端能够分析血糖数据并在APP终端屏幕上显示血糖浓度。其可以有效解决设备携带不便，易损坏的问题。但是，葡萄糖感应探头作为植入皮下的针形电化学传感器容易受体内物质迅速沉积/粘附在植入部位，严重影响它的性能，此外，取出植入式的传感器也非常不便利。The Chinese invention patent application "A wireless, real-time blood glucose monitor" (authorization announcement number CN204618248U, authorization announcement date 2015.09.09) discloses a wireless, real-time blood glucose monitor, which is mainly composed of a monitoring terminal and an APP terminal. The monitoring end includes a glucose sensing probe and a wireless data transmitter; the wireless data transmitter is connected with the glucose sensing probe, and transmits the blood glucose data provided by the glucose sensing probe to the APP terminal; the APP terminal can analyze the blood glucose data and The blood glucose concentration is displayed on the APP terminal screen. It can effectively solve the problems of inconvenient carrying and easy damage of the equipment. However, as a needle-shaped electrochemical sensor implanted under the skin, the glucose-sensing probe is prone to the rapid deposition/adherence of the substance in the implanted site, which seriously affects its performance. In addition, it is very inconvenient to take out the implanted sensor.
针对植入式传感器的缺陷，中国发明专利“动态连续测定体液中分析物的便携式监测系统”（申请公告号103932718A，申请公布日 2014.07.23）公开一种动态连续测定体液中分析物的便携式监测系统，其包括：贴身亚系统和紧凑型佩戴式电子仪。贴身亚系统包括微针体液采集器、微流体生物芯片，微流体泵、贴身式电子仪、以及测试校准式和废液收集器；各个部分通过微导管一次相互连接贯通、组成一个完整流体通路。这里采用的微流体生物芯片是由流通型微流体芯片和薄膜生物传感器组装而成；薄膜生物传感器是基于三电极电流型传感器，生物传感器的表面与流经的体液接触，连续监测体液中的物质。基于体液的动态连续血糖监测系统只能在血浆葡萄糖扩散到组织液并达到平衡状态后，血糖和组织浆液葡萄糖的浓度相差不大时，才具有一定的准确性，同时有研究表明基于体液的动态连续血糖监测数值较基于血液测血糖值低（38±15）%，会夸大液监低血糖，造成假性血糖值准确性的影响。In view of the defects of implantable sensors, the Chinese invention patent "Portable Monitoring System for Dynamic and Continuous Determination of Analytes in Body Fluids" (Application Announcement No. 103932718A, application publication date 2014.07.23) discloses a portable monitoring system for dynamic and continuous determination of analytes in body fluids A system comprising: an on-body subsystem and a compact wearable electronic instrument. The close-fitting subsystem includes a micro-needle body fluid collector, a microfluidic biochip, a microfluidic pump, a close-fitting electronic instrument, and a test calibration type and a waste liquid collector; all parts are connected to each other through a micro-catheter at one time to form a complete fluid path. The microfluidic biochip used here is assembled from a flow-through microfluidic chip and a thin-film biosensor; the thin-film biosensor is based on a three-electrode amperometric sensor, and the surface of the biosensor is in contact with the flowing body fluid to continuously monitor the substances in the body fluid . The continuous blood glucose monitoring system based on body fluids can only have certain accuracy when the plasma glucose diffuses into the tissue fluid and reaches an equilibrium state, and the concentration of blood glucose and tissue plasma glucose is not much different. The blood glucose monitoring value is (38±15)% lower than the blood glucose value based on blood measurement, which will exaggerate the hypoglycemia of liquid monitoring and cause the impact of false blood glucose value accuracy.
发明内容SUMMARY OF THE INVENTION
本发明所要解决的技术问题是提供了一种基于NFC的连续血糖检测仪及检测方法。The technical problem to be solved by the present invention is to provide an NFC-based continuous blood glucose detector and a detection method.
为解决上述技术问题，本发明采用如下技术方案：In order to solve the above-mentioned technical problems, the present invention adopts the following technical solutions:
一种基于NFC的连续血糖检测仪，其包括血糖采集前端，所述血糖采集前端包括酶化学生物传感器、恒电势电路、信号处理电路、微处理器和NFC标签，所述酶化学生物传感器的输出端经信号处理电路电连接入微处理器，恒电势电路电连接酶化学生物传感器的输入端，所述微处理器的内部集成NFC标签。An NFC-based continuous blood glucose detector, comprising a blood glucose collection front-end, the blood glucose collection front-end comprising an enzymatic chemical biosensor, a potentiostatic circuit, a signal processing circuit, a microprocessor and an NFC tag, the output of the enzymatic chemical biosensor The terminal is electrically connected to the microprocessor through the signal processing circuit, the potentiostatic circuit is electrically connected to the input end of the enzyme chemical biosensor, and the microprocessor is internally integrated with an NFC tag.
进一步的，本发明还包括与血糖采集前端中NFC标签通过射频信号相通信的NFC阅读器，所述NFC阅读器读取信息并进行解码后和移动电子终端的处理器通信。Further, the present invention also includes an NFC reader that communicates with the NFC tag in the blood glucose collection front end through radio frequency signals, and the NFC reader reads and decodes the information and communicates with the processor of the mobile electronic terminal.
进一步的，所述移动电子终端与服务器通信，服务器上服务端搭载有应用软件用于实现数据的接收和处理，所述服务器还连接有数据库。Further, the mobile electronic terminal communicates with a server, the server is equipped with application software for realizing data reception and processing, and the server is also connected with a database.
进一步的，所述移动电子终端为智能手机，所述智能手机上处理器搭载有客户端应用软件。Further, the mobile electronic terminal is a smart phone, and the processor on the smart phone is equipped with client application software.
一种基于NFC的连续血糖检测方法，其方法如下：由酶化学生物传感器采集血糖，酶化学生物传感器利用葡萄糖氧化酶的催化作用，将葡萄糖氧化后通过恒电势电路将反应中化学物质的变化转变成电信号输出，利用后续的信号处理电路对电信号放大处理后由微处理器识别，微处理器通过内部集成NFC标签将识别的电压信号实时发送。A continuous blood glucose detection method based on NFC, the method is as follows: blood glucose is collected by an enzyme chemical biosensor, and the enzyme chemical biosensor utilizes the catalysis of glucose oxidase to oxidize the glucose and then convert the changes of chemical substances in the reaction through a potentiostatic circuit. The electrical signal is output, and the electrical signal is amplified and processed by the subsequent signal processing circuit and then recognized by the microprocessor. The microprocessor sends the identified voltage signal in real time through the internal integrated NFC tag.
进一步的，所述微处理器通过NFC标签将识别的电压信号实时发送至移动电子终端，由移动电子终端的处理器实时处理。Further, the microprocessor sends the identified voltage signal to the mobile electronic terminal in real time through the NFC tag, and the processor of the mobile electronic terminal processes in real time.
进一步的，移动电子终端的处理器驱动与之电连接的NFC阅读器发出射频信号产生感应电场，NFC标签通过感应电场中感应电流获得能量供血糖采集前端工作，并发出存储在血糖采集前端的电子编码信息，NFC阅读器读取电子编码信息并进行解码后，实现血糖采集前端和移动电子终端的通信。Further, the processor of the mobile electronic terminal drives the NFC reader electrically connected to it to send out a radio frequency signal to generate an induced electric field, and the NFC tag obtains energy through the induced current in the induced electric field for the blood sugar collection front-end to work, and sends out electronic signals stored in the blood sugar collection front-end. After the NFC reader reads and decodes the electronically encoded information, the communication between the blood glucose collection front-end and the mobile electronic terminal is realized.
进一步的，移动电子终端用于数据显示和处理并将数据发送给服务器，服务器通过部署响应的程序实现对数据的分析处理，并能够向智移动电子终端反馈数据处理的结果。Further, the mobile electronic terminal is used for data display and processing and sends the data to the server, and the server realizes the analysis and processing of the data by deploying the corresponding program, and can feed back the data processing result to the smart mobile electronic terminal.
进一步的，所述移动电子终端与服务器通信，服务器上服务端搭载有应用软件用于实现数据的接收和处理，所述服务器还连接有数据库。Further, the mobile electronic terminal communicates with a server, the server is equipped with application software for realizing data reception and processing, and the server is also connected with a database.
进一步的，所述移动电子终端为智能手机，供智能手机APP终端实时处理。Further, the mobile electronic terminal is a smart phone for real-time processing by the smart phone APP terminal.
本发明的原理如下：The principle of the present invention is as follows:
酶化学生物传感器本质上由半透膜包裹的葡萄糖电化学感应电极，由于它的尺寸很小，在不会引起剧烈疼痛的情况下进入皮下毛细血管中，与血液直接接触，血液中的葡萄糖在感应电极中包裹的葡萄糖氧化酶的作用下，产生微电流信号。The enzymatic chemical biosensor is essentially a glucose electrochemical sensing electrode wrapped by a semi-permeable membrane. Due to its small size, it can enter the subcutaneous capillaries without causing severe pain, and is in direct contact with the blood. The glucose in the blood is Under the action of glucose oxidase encapsulated in the sensing electrode, a microcurrent signal is generated.
血糖连续采集由酶化学生物传感器完成，其测量过程依赖于葡萄糖的催化氧化，利用酶产生过氧化氢，随后的的过氧化氢的电化学氧化产生一个可测量的电流，该电流与血液样品中的葡萄糖浓度成正比。The continuous acquisition of blood glucose is accomplished by an enzymatic chemical biosensor, whose measurement process relies on the catalytic oxidation of glucose, using enzymes to generate hydrogen peroxide, and subsequent electrochemical oxidation of hydrogen peroxide to generate a measurable current that is correlated with the blood sample. proportional to the glucose concentration.
血糖采集前端的工作核心是恒电势电路，电流测量法通常使用三种电极：参考电极RE、控制电极CE和工作电极WE。恒电位电路设定工作电极电压，利用酶产生的过氧化氢进行氧化，测量过氧化氢发生电化学氧化反应产生的电流。The working core of the blood glucose collection front-end is the potentiostatic circuit. The current measurement method usually uses three electrodes: the reference electrode RE, the control electrode CE and the working electrode WE. The potentiostatic circuit sets the voltage of the working electrode, uses the hydrogen peroxide produced by the enzyme for oxidation, and measures the current generated by the electrochemical oxidation reaction of the hydrogen peroxide.
酶化学生物传感器输出的信号极其微弱，微弱电流需要经过转换、放大处理之后才能被NFC标签中的微处理器识别，微处理器将识别后的电压信号通过无线NFC模块发送，NFC无线通信的工作原理是RFID无线射频识别技术，通过电讯号识别特定目标并读取数据。The signal output by the enzyme chemical biosensor is extremely weak. The weak current needs to be converted and amplified before it can be recognized by the microprocessor in the NFC tag. The microprocessor sends the recognized voltage signal through the wireless NFC module. The work of NFC wireless communication The principle is RFID radio frequency identification technology, which identifies specific targets and reads data through electrical signals.
在本实施例中，移动电子终端以智能手机为例，智能手机相当于读写器，NFC前端构成标签和天线，当NFC前端进入到智能手机磁场后，智能手机所发出的射频信号产生感应电流，通过感应电流所获得的能量发出存储在NFC前端的电子编码信息，智能手机读取信息并进行解码后，可以实现智能手机和NFC前端的通信。In this embodiment, the mobile electronic terminal takes a smartphone as an example. The smartphone is equivalent to a reader, and the NFC front end constitutes a tag and an antenna. When the NFC front end enters the magnetic field of the smartphone, the radio frequency signal sent by the smartphone generates an induced current. , The energy obtained by the induced current sends out the electronically encoded information stored in the NFC front end. After the smartphone reads the information and decodes it, the communication between the smartphone and the NFC front end can be realized.
在智能手机APP终端进行手机APP开发，实现了用户设置参数和血糖浓度数据的存储，查询和分析的功能。智能手机终端APP采用Google Android平台开发，融合目前GPRS、CDMA、3G和4G等移动通信技术，使用MySQL进行后台服务器的管理。The mobile APP development is carried out on the smartphone APP terminal, which realizes the functions of storage, query and analysis of user-set parameters and blood glucose concentration data. The smartphone terminal APP is developed on the Google Android platform, integrates the current mobile communication technologies such as GPRS, CDMA, 3G and 4G, and uses MySQL to manage the background server.
后台服务器将实时采集血糖信息进行存储和处理，即可对血糖监测进行实时管理，同时，医师可据此将合理的用药建议和作息安排反馈给患者。后台服务器采用JSP和Java Servlet开发，android移动终端与MySQL数据库通信选择JSON作为数据交互的方法。The background server will collect real-time blood glucose information for storage and processing, so as to manage blood glucose monitoring in real time. At the same time, doctors can feed back reasonable medication recommendations and schedules to patients accordingly. The background server is developed with JSP and Java Servlet, and JSON is selected as the data interaction method for the communication between the android mobile terminal and the MySQL database.
JSON是一种轻量级的数据交互格式，是基于Java Script的一个子集。Android访问远程服务器前端的Java Script，Java Script完成数据库操作，把结果经过JSON编码后传回，Android端再解析出结果。JSON is a lightweight data interaction format based on a subset of Java Script. Android accesses the Java Script on the front end of the remote server. The Java Script completes the database operation, encodes the result in JSON and sends it back, and then parses the result on the Android side.
本发明的有益效果如下：The beneficial effects of the present invention are as follows:
本发明专利提供了一种基于NFC的连续血糖检测仪及检测方法，针对现有血糖检测技术在实用性、便利性和系统功耗上的不足，本发明中移动电子终端与血糖检测仪的通信主要由NFC前端来完成，其能量提供由NFC前端通过天线耦合产生能量供电。一方面实现了基于血糖检测方法的优点，实现快读建立连接，且本发明血糖检测仪工作时始终保持的较低的功耗，节省了成本；另一方面实现了测量的长期存储，患者本身或监护人员可随时查看监测数据，及时了解患者健康情况，使血糖得到有效控制。The patent of the present invention provides a continuous blood glucose detector and a detection method based on NFC. In view of the shortcomings of the existing blood glucose detection technology in terms of practicability, convenience and system power consumption, the communication between the mobile electronic terminal and the blood glucose detector in the present invention mainly It is completed by the NFC front-end, and its energy is supplied by the NFC front-end through antenna coupling to generate energy supply. On the one hand, the advantages based on the blood sugar detection method are realized, the connection is established by quick reading, and the blood sugar detector of the present invention always maintains low power consumption when working, saving costs; on the other hand, it realizes long-term storage of the measurement, and the patient itself Or the guardian can check the monitoring data at any time, keep abreast of the patient's health, and effectively control the blood sugar.
附图说明Description of drawings
为了更清楚地说明本发明具体实施方式或现有技术中的技术方案，下面将对具体实施方式或现有技术描述中所需要使用的附图作简单地介绍，显而易见地，下面描述中的附图是本发明的一些实施方式，对于本领域普通技术人员来讲，在不付出创造性劳动的前提下，还可以根据这些附图获得其它的附图。In order to illustrate the specific embodiments of the present invention or the technical solutions in the prior art more clearly, the following briefly introduces the accompanying drawings that need to be used in the description of the specific embodiments or the prior art. Obviously, the accompanying drawings in the following description The drawings are some embodiments of the present invention. For those of ordinary skill in the art, other drawings can also be obtained based on these drawings without creative efforts.
图1为本发明的结构原理框图。FIG. 1 is a structural principle block diagram of the present invention.
图2为本发明中恒电势电路的原理示意图。FIG. 2 is a schematic diagram of the principle of the potentiostatic circuit in the present invention.
图3为本发明中信号处理电路的原理示意图。FIG. 3 is a schematic diagram of the principle of the signal processing circuit in the present invention.
具体实施方式Detailed ways
为使本发明的目的、技术方案和优点更加清楚，下面结合图1-图3和具体实施例对发明进行清楚、完整的描述。In order to make the objectives, technical solutions and advantages of the present invention clearer, the present invention will be clearly and completely described below with reference to FIGS. 1 to 3 and specific embodiments.
如图1所示，本实施例涉及一种基于NFC的连续血糖检测仪，采用生物传感器技术、NFC无线通信将血糖参数发送到智能手机上，并可将数据远程传输到服务器平台，利用网络技术和软件技术来实现血糖数据的管理和分析。As shown in Figure 1, this embodiment relates to an NFC-based continuous blood glucose detector, which uses biosensor technology and NFC wireless communication to send blood glucose parameters to a smartphone, and can remotely transmit data to a server platform, using network technology And software technology to realize the management and analysis of blood glucose data.
一种基于NFC的连续血糖检测仪，其包括血糖采集前端1，所述血糖采集前端1包括酶化学生物传感器11、恒电势电路12、信号处理电路13、微处理器和NFC标签14，所述酶化学生物传感器11的输出端经信号处理电路13电连接入微处理器，恒电势电路12电连接酶化学生物传感器11的输入端，所述微处理器的内部集成NFC标签14。An NFC-based continuous blood glucose detector includes a blood glucose collection front end 1, the blood glucose collection front end 1 includes an enzymatic chemical biosensor 11, a potentiostatic circuit 12, a signal processing circuit 13, a microprocessor and an NFC tag 14, the The output end of the enzymatic chemical biosensor 11 is electrically connected to the microprocessor via the signal processing circuit 13 , the potentiostatic circuit 12 is electrically connected to the input end of the enzymatic chemical biosensor 11 , and the microprocessor integrates an NFC tag 14 .
进一步的，基于NFC的连续血糖检测仪还包括与血糖采集前端1中NFC标签14通过射频信号相通信的NFC阅读器21，所述NFC阅读器21读取信息并进行解码后和移动电子终端2的处理器通信。Further, the NFC-based continuous blood glucose detector also includes an NFC reader 21 that communicates with the NFC tag 14 in the blood glucose collection front end 1 through radio frequency signals. The NFC reader 21 reads and decodes the information and communicates with the mobile electronic terminal 2. processor communication.
进一步的，血糖采集前端1有多种佩戴方式，主要以臂部敷贴式为主，有一个纽扣装的酶化学生物传感器11、信号处理电路13和NFC标签14。Further, the blood glucose collection front-end 1 has a variety of wearing methods, mainly the arm application type, and has a button-mounted enzyme chemical biosensor 11 , a signal processing circuit 13 and an NFC tag 14 .
本发明的基于NFC的连续血糖检测仪的原理如下：The principle of the NFC-based continuous blood glucose detector of the present invention is as follows:
酶化学生物传感器本质上由半透膜包裹的葡萄糖电化学感应电极，由于它的尺寸很小，在不会引起剧烈疼痛的情况下进入皮下毛细血管中，与血液直接接触，血液中的葡萄糖在感应电极中包裹的葡萄糖氧化酶的作用下，产生微电流信号。The enzymatic chemical biosensor is essentially a glucose electrochemical sensing electrode wrapped by a semi-permeable membrane. Due to its small size, it can enter the subcutaneous capillaries without causing severe pain, and is in direct contact with the blood. The glucose in the blood is Under the action of glucose oxidase encapsulated in the sensing electrode, a microcurrent signal is generated.
血糖连续采集由酶化学生物传感器完成，其测量过程依赖于葡萄糖的催化氧化，利用酶产生过氧化氢，随后的的过氧化氢的电化学氧化产生一个可测量的电流，该电流与血液样品中的葡萄糖浓度成正比。The continuous acquisition of blood glucose is accomplished by an enzymatic chemical biosensor, whose measurement process relies on the catalytic oxidation of glucose, using enzymes to generate hydrogen peroxide, and subsequent electrochemical oxidation of hydrogen peroxide to generate a measurable current that is correlated with the blood sample. proportional to the glucose concentration.
血糖采集前端1的工作核心是恒电势电路12，电流测量法通常使用三种电极：参考电极RE、控制电极CE和工作电极WE。恒电位电路设定工作电极电压，利用酶产生的过氧化氢进行氧化，测量过氧化氢发生电化学氧化反应产生的电流。The working core of the blood glucose collection front-end 1 is the potentiostatic circuit 12, and the amperometric method usually uses three electrodes: the reference electrode RE, the control electrode CE, and the working electrode WE. The potentiostatic circuit sets the voltage of the working electrode, uses the hydrogen peroxide produced by the enzyme for oxidation, and measures the current generated by the electrochemical oxidation reaction of the hydrogen peroxide.
酶化学生物传感器11输出的信号极其微弱，微弱电流需要经过转换、放大处理之后才能被NFC标签中的微处理器识别，微处理器将识别后的电压信号通过无线NFC模块发送，NFC无线通信的工作原理是RFID无线射频识别技术，通过电讯号识别特定目标并读取数据。The signal output by the enzyme chemical biosensor 11 is extremely weak, and the weak current needs to be converted and amplified before it can be recognized by the microprocessor in the NFC tag. The microprocessor sends the recognized voltage signal through the wireless NFC module. The working principle is RFID radio frequency identification technology, which identifies specific targets and reads data through electrical signals.
在本实施例中，移动电子终端2以智能手机为例，智能手机相当于读写器，NFC前端构成标签和天线，当NFC前端进入到智能手机磁场后，智能手机所发出的射频信号产生感应电流，通过感应电流所获得的能量发出存储在NFC前端的电子编码信息，智能手机读取信息并进行解码后，可以实现智能手机和NFC前端的通信。In this embodiment, the mobile electronic terminal 2 takes a smart phone as an example. The smart phone is equivalent to a reader, and the NFC front end constitutes a tag and an antenna. When the NFC front end enters the magnetic field of the smart phone, the radio frequency signal sent by the smart phone generates induction The energy obtained by inducing the current sends out the electronically encoded information stored in the NFC front end. After the smartphone reads and decodes the information, the communication between the smartphone and the NFC front end can be realized.
在智能手机APP终端进行手机APP开发，实现了用户设置参数和血糖浓度数据的存储，查询和分析的功能。智能手机终端APP采用Google Android平台开发，融合目前GPRS、CDMA、3G和4G等移动通信技术，使用MySQL进行后台服务器3的管理。The mobile APP development is carried out on the smartphone APP terminal, which realizes the functions of storage, query and analysis of user-set parameters and blood glucose concentration data. The smartphone terminal APP is developed on the Google Android platform, integrates the current mobile communication technologies such as GPRS, CDMA, 3G and 4G, and uses MySQL to manage the background server 3.
后台服务器3将实时采集血糖信息进行存储和处理，即可对血糖监测进行实时管理，同时，医师可据此将合理的用药建议和作息安排反馈给患者。后台服务器3采用JSP和Java Servlet开发，android移动终端与MySQL数据库通信选择JSON作为数据交互的方法。The background server 3 stores and processes the real-time blood glucose information collected, so that the blood glucose monitoring can be managed in real time, and at the same time, the doctor can feed back reasonable medication recommendations and schedules to the patient accordingly. The background server 3 is developed with JSP and Java Servlet, and JSON is selected as the data interaction method for the communication between the android mobile terminal and the MySQL database.
JSON是一种轻量级的数据交互格式，是基于Java Script的一个子集。Android访问远程服务器前端的Java Script，Java Script完成数据库操作，把结果经过JSON编码后传回，Android端再解析出结果。JSON is a lightweight data interaction format based on a subset of Java Script. Android accesses the Java Script on the front end of the remote server. The Java Script completes the database operation, encodes the result in JSON and sends it back, and then parses the result on the Android side.
进一步的，所述移动电子终端2与服务器3通信，服务器3上服务端31搭载有应用软件用于实现数据的接收和处理，所述服务器3还连接有数据库32。Further, the mobile electronic terminal 2 communicates with the server 3 , the server 31 on the server 3 is equipped with application software for realizing data reception and processing, and the server 3 is also connected with a database 32 .
进一步的，所述移动电子终端2为智能手机，所述智能手机上处理器搭载有客户端应用软件。Further, the mobile electronic terminal 2 is a smart phone, and the processor on the smart phone is equipped with client application software.
一种基于NFC的连续血糖检测方法，其方法如下：由酶化学生物传感器11采集血糖，酶化学生物传感器11利用葡萄糖氧化酶的催化作用，将葡萄糖氧化后通过恒电势电路12将反应中化学物质的变化转变成电信号输出，利用后续的信号处理电路13对电信号放大处理后由微处理器识别，微处理器通过NFC标签14将识别的电压信号实时发送。An NFC-based continuous blood sugar detection method, the method is as follows: blood sugar is collected by an enzymatic chemical biosensor 11, and the enzymatic chemical biosensor 11 utilizes the catalysis of glucose oxidase to oxidize the glucose and then pass the potentiostatic circuit 12 to react chemical substances. The change of the voltage is converted into an electrical signal output, and the electrical signal is amplified and processed by the subsequent signal processing circuit 13 and then identified by the microprocessor, and the microprocessor sends the identified voltage signal in real time through the NFC tag 14 .
进一步的，所述微处理器通过NFC标签14将识别的电压信号实时发送至移动电子终端2，由移动电子终端2的处理器实时处理。Further, the microprocessor sends the identified voltage signal to the mobile electronic terminal 2 in real time through the NFC tag 14 , and the processor of the mobile electronic terminal 2 processes in real time.
进一步的，移动电子终端2的处理器驱动与之电连接的NFC阅读器21发出射频信号产生感应电场，NFC标签14通过感应电场中感应电流获得能量供血糖采集前端1工作，并发出存储在血糖采集前端1的电子编码信息，NFC阅读器21读取电子编码信息并进行解码后，实现血糖采集前端1和移动电子终端2的通信。Further, the processor of the mobile electronic terminal 2 drives the NFC reader 21 that is electrically connected to it to send out a radio frequency signal to generate an induced electric field, and the NFC tag 14 obtains energy through the induced current in the induced electric field for the blood sugar collection front end 1 to work, and sends out a signal stored in the blood sugar. The electronic code information of the front end 1 is collected, and after the NFC reader 21 reads and decodes the electronic code information, the communication between the blood glucose collection front end 1 and the mobile electronic terminal 2 is realized.
进一步的，移动电子终端2用于数据显示和处理并将数据发送给服务器3，服务器3通过部署响应的程序实现对数据的分析处理，并能够向智移动电子终端2反馈数据处理的结果。Further, the mobile electronic terminal 2 is used for data display and processing and sends the data to the server 3 . The server 3 implements data analysis and processing by deploying the corresponding program, and can feed back the data processing result to the smart mobile electronic terminal 2 .
进一步的，所述移动电子终端2与服务器3通信，服务器3上服务端31搭载有应用软件用于实现数据的接收和处理，所述服务器3还连接有数据库32。Further, the mobile electronic terminal 2 communicates with the server 3 , the server 31 on the server 3 is equipped with application software for realizing data reception and processing, and the server 3 is also connected with a database 32 .
进一步的，所述移动电子终端2为智能手机，供智能手机APP终端实时处理。Further, the mobile electronic terminal 2 is a smart phone for real-time processing by the smart phone APP terminal.
图1是本发明的结构框图。基于NFC的连续血糖监测仪包含血糖采集前端1，其中包含酶化学生物传感器11、恒电势电路12，信号处理电路13和NFC标签14；移动电子终端2可采用智能手机APP终端实现，其中包含NFC阅读器21和客户端22；服务器平台3，其中包含服务端31和数据库32；Fig. 1 is a structural block diagram of the present invention. The NFC-based continuous blood glucose monitor includes a blood glucose acquisition front end 1, which includes an enzymatic chemical biosensor 11, a potentiostatic circuit 12, a signal processing circuit 13 and an NFC tag 14; the mobile electronic terminal 2 can be implemented by a smartphone APP terminal, which includes an NFC The reader 21 and the client 22; the server platform 3, which includes the server 31 and the database 32;
数据无线传输实现将血糖采集前端1和智能手机APP终端的信息传输，本发明在采集及传输上通过血糖采集前端1，智能手机APP终端负责数据显示和处理并将数据发送给服务器平台3；应用服务器通过部署响应的程序实现对数据的分析处理，并能够向智能手机APP终端反馈数据处理的结果；The wireless data transmission realizes the information transmission between the blood glucose collection front end 1 and the smart phone APP terminal. In the present invention, the blood glucose collection front end 1 is used for collection and transmission. The smart phone APP terminal is responsible for data display and processing and sends the data to the server platform 3; application The server implements data analysis and processing by deploying the corresponding program, and can feed back the data processing results to the smartphone APP terminal;
血糖采集前端1完成血糖的采集和数据的传输，其中血糖的采集通过酶化学生物传感器11来完成，酶化学生物传感器11利用葡萄糖氧化酶的催化作用，在常温常压和一定电压机理下将葡萄糖氧化，通过恒电势电路12将反应中化学物质的变化转变成电信号输出，利用后续信号处理电路13对微弱的电信号进行转化，放大等处理之后被微处理器识别，微处理器通过NFC标签14将识别的电压信号实时发送，供智能手机APP终端实时处理；The blood sugar collection front end 1 completes the collection of blood sugar and the transmission of data. The collection of blood sugar is completed by the enzyme chemical biosensor 11. The enzyme chemical biosensor 11 utilizes the catalytic action of glucose oxidase to convert glucose under normal temperature, normal pressure and a certain voltage mechanism. Oxidation, the change of chemical substances in the reaction is converted into electrical signal output by the potentiostatic circuit 12, and the weak electrical signal is converted by the subsequent signal processing circuit 13, amplified and processed by the microprocessor, and the microprocessor passes the NFC tag. 14 Send the identified voltage signal in real time for real-time processing by the smartphone APP terminal;
智能手机APP终端一方面完成能量的供应和数据的读取，智能手机APP终端发出射频信号产生感应电场，NFC标签14通过感应电流获得能量供血糖采集前端1工作，并发出存储在血糖采集前端1的电子编码信息，NFC阅读器21读取信息并进行解码后，可以实现血糖采集前端1和智能手机APP终端的通信；On the one hand, the smart phone APP terminal completes the supply of energy and the reading of data. The smart phone APP terminal sends out a radio frequency signal to generate an induced electric field, and the NFC tag 14 obtains energy through the induced current for the blood sugar collection front end 1 to work, and sends out the energy stored in the blood sugar collection front end 1. After the NFC reader 21 reads and decodes the electronically encoded information, the communication between the blood glucose collection front-end 1 and the smartphone APP terminal can be realized;
智能手机APP终端另一方面通过与服务器3的通信，使用服务端31实现数据的接收和处理，使用数据库32在服务器进行数据存储和管理等功能。On the other hand, the smart phone APP terminal uses the server 31 to receive and process data through communication with the server 3, and uses the database 32 to perform functions such as data storage and management on the server.
如图2所示，对恒电势电路12说明：酶化学生物传感器11工作的时候需要在工作电极和辅助电极之间电位差保持恒定，电路设计如图2所示，为提高驱动能力，在输入端加入了一个由ADA4505组成的电压跟随器。As shown in Figure 2, it is explained to the potentiostatic circuit 12 that the potential difference between the working electrode and the auxiliary electrode needs to be kept constant when the enzyme chemical biosensor 11 is working. The circuit design is shown in Figure 2. In order to improve the driving ability, the input A voltage follower composed of ADA4505 is added to the terminal.
如图3所示，对信号处理电路13说明：本发明专利将经典的运放反馈电路进行修改，使其既有将微电流转变成较大电压的功能，又具有低通滤波的功能。血糖信号电流通常低于3满量程，且血糖仪中需要用到截至频率为80Hz至100Hz的低通滤波器，以便消除噪声。电压跟随器ADA4505-2它在室温下具有典型值为0.5pA和最大值为2pA的输入偏置电流特性，且具有50KHz GBP和7典型功耗，符合较低功耗的I-V转换要求及功率要求。As shown in FIG. 3 , the signal processing circuit 13 is explained: the patent of the present invention modifies the classic operational amplifier feedback circuit, so that it not only has the function of converting a small current into a larger voltage, but also has the function of low-pass filtering. The blood glucose signal current is usually below 3 full scale, and a low-pass filter with a cutoff frequency of 80Hz to 100Hz is required in the blood glucose meter to eliminate noise. Voltage follower ADA4505-2 It has 0.5pA typical and 2pA maximum input bias current characteristics at room temperature, and has 50KHz GBP and 7 typical power consumption, which meets the I-V conversion requirements and power requirements of lower power consumption .
最后应说明的是：以上实施例仅用以说明本发明的技术方案，而非对其限制；尽管参照前述实施例对本发明进行了详细的说明，本领域的普通技术人员应当理解：其依然可以对前述实施例所记载的技术方案进行修改，或者对其中部分技术特征进行等同替换；而这些修改或者替换，并不使相应技术方案的本质脱离本发明实施例技术方案的精神和范围。Finally, it should be noted that the above embodiments are only used to illustrate the technical solutions of the present invention, but not to limit them; although the present invention has been described in detail with reference to the foregoing embodiments, those of ordinary skill in the art should understand that it can still be The technical solutions described in the foregoing embodiments are modified, or some technical features thereof are equivalently replaced; and these modifications or replacements do not make the essence of the corresponding technical solutions deviate from the spirit and scope of the technical solutions in the embodiments of the present invention.
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| CN201910643045.3ACN110368000A (en) | 2019-07-17 | 2019-07-17 | A kind of continuous blood sugar detector and detection method based on NFC |
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| CN201910643045.3ACN110368000A (en) | 2019-07-17 | 2019-07-17 | A kind of continuous blood sugar detector and detection method based on NFC |
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| CN110368000Atrue CN110368000A (en) | 2019-10-25 |
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| CN201910643045.3APendingCN110368000A (en) | 2019-07-17 | 2019-07-17 | A kind of continuous blood sugar detector and detection method based on NFC |
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| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
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| RJ01 | Rejection of invention patent application after publication | ||
| RJ01 | Rejection of invention patent application after publication | Application publication date:20191025 |