技术领域technical field
本发明医疗领域，具体而言，涉及一种消化道肿瘤发病风险评估方法及系统。The medical field of the present invention, in particular, relates to a method and system for assessing the risk of gastrointestinal tumors.
背景技术Background technique
消化道肿瘤是我国发病率最高恶性肿瘤，而且近年来的发病率不断加速攀升。我国消化道肿瘤病例占国内所有肿瘤病例近50％，其中85％左右的比例属于晚期病例。流行病学调查结果显示：中国消化系统肿瘤中，胃、食管、结肠癌死亡率分别居第2、4、5位。中国食管癌新发病例数约占全球的50％。食管癌一经临床诊断，往往已经处于中晚期，5年生存率低于20％；而食管早癌经治疗后5年生存率达90％以上。胃癌是我国常见的恶性肿瘤之一，就我国胃癌患者而言，早期癌仅占2％～10％，5年生存率达95％～97％，约85％进展期癌患者可以手术治疗，5年生存率仅为20％～30％。结直肠癌是我国常见的恶性肿瘤之一，且随着生活水平的提高、生活方式及膳食结构的改变，其发病率逐年增高，而确诊的结直肠癌中，晚期患者占大多数，其5年生存率约为50％。早期消化道肿瘤往往无特异性症状，导致多数患者确诊时肿瘤已到进展期，虽然经过外科手术和物理化学辅助治疗，病死率仍居高不下。Gastrointestinal tumors are the malignant tumors with the highest incidence in my country, and the incidence has been increasing rapidly in recent years. Digestive tract tumor cases in my country account for nearly 50% of all tumor cases in China, of which about 85% are advanced cases. Epidemiological survey results show that among the digestive system tumors in China, the mortality rates of gastric, esophageal and colon cancers rank second, fourth and fifth respectively. The number of new esophageal cancer cases in China accounts for about 50% of the global total. Once clinically diagnosed, esophageal cancer is often in the middle and late stages, and the 5-year survival rate is less than 20%; while the 5-year survival rate of early esophageal cancer after treatment is over 90%. Gastric cancer is one of the common malignant tumors in my country. For gastric cancer patients in China, early-stage cancer only accounts for 2% to 10%, and the 5-year survival rate is 95% to 97%. About 85% of advanced cancer patients can be treated by surgery. 5 The annual survival rate is only 20% to 30%. Colorectal cancer is one of the common malignant tumors in my country, and with the improvement of living standards, changes in lifestyle and dietary structure, the incidence rate is increasing year by year. The annual survival rate is about 50%. Early-stage gastrointestinal tumors often have no specific symptoms, leading to the fact that most patients have advanced tumors when they are diagnosed.
国内大多数消化道肿瘤诊断时已近晚期，失去救治机会，给家庭和个人带来巨大损失，严重影响人民生活健康。造成这一现状的原因是消化道肿瘤的早期诊断率极低，早期肿瘤诊断率低是造成患者临床预后不良的最主要原因。可见，早期诊断和治疗是目前提高消化道肿瘤患者生存率的有效手段。Most of the gastrointestinal tumors in China are diagnosed at an advanced stage and lose the opportunity for treatment, which brings huge losses to families and individuals, and seriously affects people's life and health. The reason for this situation is that the early diagnosis rate of digestive tract tumors is extremely low, which is the main reason for the poor clinical prognosis of patients. It can be seen that early diagnosis and treatment are effective means to improve the survival rate of patients with gastrointestinal tumors.
发明内容SUMMARY OF THE INVENTION
本发明的主要目的在于提供一种消化道肿瘤发病风险评估方法及系统，以解决现有技术中对消化道肿瘤的早期诊断率极低的问题。The main purpose of the present invention is to provide a risk assessment method and system for gastrointestinal tumors, so as to solve the problem that the early diagnosis rate of gastrointestinal tumors is extremely low in the prior art.
为了实现上述目的，本发明提供了一种消化道肿瘤发病风险评估方法，包括：获取目标对象的风险信息，所述风险信息至少包括：生活质量信息和个体环境信息；使用消化道肿瘤发病风险模型对所述风险信息进行分析，估计消化道肿瘤危险因素的危险分值，其中，所述消化道肿瘤发病风险模型为使用多组数据通过机器学习训练出的，所述多组数据中的每组数据均包括：风险信息和风险信息对应的危险分值；根据所述危险分值，确定所述目标对象的消化道肿瘤发病风险。In order to achieve the above object, the present invention provides a risk assessment method for gastrointestinal tumors, including: acquiring risk information of a target object, where the risk information at least includes: quality of life information and individual environmental information; using a risk model for gastrointestinal tumors The risk information is analyzed to estimate the risk score of the risk factors for digestive tract tumors, wherein the digestive tract tumor incidence risk model is trained by using multiple sets of data through machine learning, and each group of the multiple sets of data The data all include: risk information and a risk score corresponding to the risk information; according to the risk score, determine the risk of gastrointestinal tumor of the target object.
可选地，所述生活质量信息至少包括：日常活动质量信息、睡眠质量信息、疾病信息、精神状况、经济状况、社交状况；所述个体环境信息至少包括：身高、体重、饮食信息、体力活动信息、家族信息。Optionally, the quality of life information includes at least: daily activity quality information, sleep quality information, disease information, mental status, economic status, and social status; the individual environmental information includes at least: height, weight, diet information, physical activity information, family information.
可选地，所述使用消化道肿瘤发病风险模型对所述风险信息进行分析，估计消化道肿瘤危险因素的危险分值包括：根据所述生活质量信息，计算功能型分值和症状型分值，所述功能型分值用于反映所述目标对象的躯体功能、情绪功能、角色功能、认知功能、社会功能以及健康状况，所述症状型分值用于反映所述目标对象的机体症状；根据所述个体环境信息，计算个体环境分值；根据所述功能型分值、所述症状型分值和所述个体环境分值，计算所述危险分值。Optionally, analyzing the risk information by using a gastrointestinal tumor incidence risk model, and estimating the risk score of the gastrointestinal tumor risk factor includes: calculating a functional score and a symptom score according to the quality of life information. , the functional score is used to reflect the physical function, emotional function, role function, cognitive function, social function and health status of the target object, and the symptom score is used to reflect the body symptoms of the target object ; Calculate an individual environment score according to the individual environment information; calculate the risk score according to the functional type score, the symptom type score and the individual environment score.
可选地，所述个体环境信息还包括：身高、体重；其中，所述根据所述个体环境信息，计算个体环境分值包括：根据所述饮食信息计算营养素摄入量，并确定所述营养素摄入量对应的第一分值；根据体力活动信息计算体力活动代谢当量，并确定所述体力活动代谢当量对应的第二分值；根据所述身高和所述体重计算身体质量指数，并确定所述身体质量指数对应的第三分值；根据所述第一分值、所述第二分值以及所述第三分值，得到所述个体环境分值。Optionally, the individual environmental information further includes: height and weight; wherein, calculating the individual environmental score according to the individual environmental information includes: calculating the nutrient intake according to the dietary information, and determining the nutrient the first score corresponding to the intake; calculate the metabolic equivalent of physical activity according to the physical activity information, and determine the second score corresponding to the metabolic equivalent of the physical activity; calculate the body mass index according to the height and the weight, and determine The third score corresponding to the body mass index; the individual environment score is obtained according to the first score, the second score and the third score.
可选地，所述根据所述危险分值，确定所述目标对象的消化道肿瘤发病风险包括：根据所述危险分值，确定风险等级；根据所述风险等级，得到所述目标对象的消化道肿瘤发病风险。Optionally, the determining the risk of gastrointestinal tumor of the target object according to the risk score includes: determining a risk level according to the risk score; obtaining the digestive tract tumor of the target object according to the risk level Risk of tract cancer.
本发明还提供了一种消化道肿瘤发病风险评估系统，包括：获取模块，用于获取目标对象的风险信息，所述风险信息至少包括：生活质量信息和个体环境信息；分析模块，用于使用消化道肿瘤发病风险模型对所述风险信息进行分析，估计消化道肿瘤危险因素的危险分值，其中，所述消化道肿瘤发病风险模型为使用多组数据通过机器学习训练出的，所述多组数据中的每组数据均包括：风险信息和风险信息对应的危险分值；处理模块，用于根据所述危险分值，确定所述目标对象的消化道肿瘤发病风险。The present invention also provides a risk assessment system for gastrointestinal tumors, comprising: an acquisition module for acquiring risk information of a target object, the risk information at least including: life quality information and individual environment information; an analysis module for using The risk model for gastrointestinal tumors analyzes the risk information, and estimates the risk score of risk factors for gastrointestinal tumors, wherein the gastrointestinal tumor incidence risk model is trained by using multiple sets of data through machine learning, and the multiple sets of data are used for training. Each group of data in the group data includes: risk information and a risk score corresponding to the risk information; a processing module, configured to determine the risk of gastrointestinal tumor of the target object according to the risk score.
可选地，所述生活质量信息至少包括：日常活动质量信息、睡眠质量信息、疾病信息、精神状况、经济状况、社交状况；所述个体环境信息至少包括：身高、体重、饮食信息、体力活动信息、家族信息。Optionally, the quality of life information includes at least: daily activity quality information, sleep quality information, disease information, mental status, economic status, and social status; the individual environmental information includes at least: height, weight, diet information, physical activity information, family information.
可选地，所述分析模块用于执行以下步骤使用消化道肿瘤发病风险模型对所述风险信息进行分析，估计消化道肿瘤危险因素的危险分值：根据所述生活质量信息，计算功能型分值和症状型分值，所述功能型分值用于反映所述目标对象的躯体功能、情绪功能、角色功能、认知功能、社会功能以及健康状况，所述症状型分值用于反映所述目标对象的机体症状；根据所述个体环境信息，计算个体环境分值；根据所述功能型分值、所述症状型分值和所述个体环境分值，计算所述危险分值。Optionally, the analysis module is configured to perform the following steps to analyze the risk information using a gastrointestinal tumor incidence risk model, and estimate the risk score of the risk factors for gastrointestinal tumors: calculating a functional score according to the quality of life information. value and symptom score, the functional score is used to reflect the physical function, emotional function, role function, cognitive function, social function and health status of the target object, and the symptom score is used to reflect all the The body symptoms of the target object; according to the individual environment information, the individual environment score is calculated; the risk score is calculated according to the functional type score, the symptom type score and the individual environment score.
可选地，所述个体环境信息还包括：身高、体重；其中，所述分析模块用于执行以下步骤根据所述个体环境信息，计算个体环境分值：根据所述饮食信息计算营养素摄入量，并确定所述营养素摄入量对应的第一分值；根据体力活动信息计算体力活动代谢当量，并确定所述体力活动代谢当量对应的第二分值；根据所述身高和所述体重计算身体质量指数，并确定所述身体质量指数对应的第三分值；根据所述第一分值、所述第二分值以及所述第三分值，得到所述个体环境分值。Optionally, the individual environmental information further includes: height and weight; wherein, the analysis module is configured to perform the following steps to calculate the individual environmental score according to the individual environmental information: calculate the nutrient intake according to the dietary information , and determine the first score corresponding to the nutrient intake; calculate the physical activity metabolic equivalent according to the physical activity information, and determine the second score corresponding to the physical activity metabolic equivalent; calculate according to the height and the weight body mass index, and determine a third score corresponding to the body mass index; and obtain the individual environment score according to the first score, the second score, and the third score.
可选地，所述处理模块用于执行以下步骤根据所述危险分值，确定所述目标对象的消化道肿瘤发病风险：根据所述危险分值，确定风险等级；根据所述风险等级，得到所述目标对象的消化道肿瘤发病风险。Optionally, the processing module is configured to perform the following steps to determine the gastrointestinal tumor incidence risk of the target object according to the risk score: to determine a risk level according to the risk score; to obtain according to the risk level. The risk of gastrointestinal tumors of the target subject.
应用本发明技术方案的消化道肿瘤发病风险评估方法及系统，通过获取目标对象的风险信息，风险信息至少包括：生活质量信息和个体环境信息；使用消化道肿瘤发病风险模型对风险信息进行分析，估计消化道肿瘤危险因素的危险分值，其中，消化道肿瘤发病风险模型为使用多组数据通过机器学习训练出的，多组数据中的每组数据均包括：风险信息和风险信息对应的危险分值；根据危险分值，确定目标对象的消化道肿瘤发病风险。从而能够基于地区性肿瘤发病风险特点，通过消化道肿瘤发病风险模型网络化高效应用，有针对性的进行筛查而提高消化道早期肿瘤检出率，提高患者的临床生存率。解决了现有技术中对消化道肿瘤的早期诊断率极低的问题。Using the method and system for risk assessment of gastrointestinal tumor incidence according to the technical solution of the present invention, the risk information of the target object is obtained by obtaining the risk information, and the risk information at least includes: life quality information and individual environmental information; the risk information is analyzed by using the gastrointestinal tumor incidence risk model, Estimating the risk scores of risk factors for gastrointestinal tumors, wherein the risk model for gastrointestinal tumors is trained by machine learning using multiple sets of data, and each set of data in the multiple sets of data includes: risk information and risk information corresponding to the risk information Score; according to the risk score, determine the risk of gastrointestinal tumors of the target object. Therefore, based on the characteristics of regional tumor incidence risk, the networked and efficient application of the gastrointestinal tumor incidence risk model can be used for targeted screening to improve the detection rate of early gastrointestinal tumors and improve the clinical survival rate of patients. The problem of extremely low early diagnosis rate of digestive tract tumors in the prior art is solved.
附图说明Description of drawings
构成本申请的一部分的说明书附图用来提供对本发明的进一步理解，本发明的示意性实施例及其说明用于解释本发明，并不构成对本发明的不当限定。在附图中：The accompanying drawings forming a part of the present application are used to provide further understanding of the present invention, and the exemplary embodiments of the present invention and their descriptions are used to explain the present invention and do not constitute an improper limitation of the present invention. In the attached image:
图1是根据本发明实施例一种可选的消化道肿瘤发病风险评估方法的流程示意图；1 is a schematic flowchart of an optional method for assessing the risk of gastrointestinal tumors according to an embodiment of the present invention;
图2是根据本发明实施例另一种可选的消化道肿瘤发病风险评估方法的流程示意图；2 is a schematic flowchart of another alternative method for assessing the risk of gastrointestinal tumor incidence according to an embodiment of the present invention;
图3是根据本发明实施例一种可选的消化道肿瘤发病风险评估系统的结构示意图。3 is a schematic structural diagram of an optional digestive tract tumor incidence risk assessment system according to an embodiment of the present invention.
具体实施方式Detailed ways
需要说明的是，在不冲突的情况下，本申请中的实施例及实施例中的特征可以相互组合。下面将参考附图并结合实施例来详细说明本发明。It should be noted that the embodiments in the present application and the features of the embodiments may be combined with each other in the case of no conflict. The present invention will be described in detail below with reference to the accompanying drawings and in conjunction with the embodiments.
实施例1Example 1
根据本发明实施例的消化道肿瘤发病风险评估方法，如图1所示，该方法包括以下步骤：According to the method for assessing the risk of gastrointestinal tumor incidence according to an embodiment of the present invention, as shown in FIG. 1 , the method includes the following steps:
步骤S101，获取目标对象的风险信息。Step S101, acquiring risk information of the target object.
其中，风险信息至少包括：生活质量信息和个体环境信息。The risk information includes at least: quality of life information and individual environmental information.
具体地，所述生活质量信息至少包括：日常活动质量信息、睡眠质量信息、疾病信息、精神状况、经济状况、社交状况；所述个体环境信息至少包括：身高、体重、饮食信息、体力活动信息、家族信息。Specifically, the quality of life information includes at least: daily activity quality information, sleep quality information, disease information, mental status, economic status, and social status; the individual environmental information includes at least: height, weight, diet information, and physical activity information , family information.
步骤S102，使用消化道肿瘤发病风险模型对所述风险信息进行分析，估计消化道肿瘤危险因素的危险分值。In step S102, the risk information is analyzed by using a risk model of gastrointestinal tumor incidence, and the risk score of the risk factors of the gastrointestinal tumor is estimated.
其中，所述消化道肿瘤发病风险模型为使用多组数据通过机器学习训练出的，所述多组数据中的每组数据均包括：风险信息和风险信息对应的危险分值。Wherein, the gastrointestinal tumor incidence risk model is trained by using multiple sets of data through machine learning, and each set of data in the multiple sets of data includes: risk information and a risk score corresponding to the risk information.
本实施例的消化道肿瘤发病风险模型是通过大量的数据通过机器学习训练出的，这些数据可以通过网络信息化问卷的形式进行信息采集。为了便于信息收集，提高受试者依从性和。为统计分析提供可靠的数据，网络信息化问卷将通过二维码扫描方式进行，信息提交后由服务器分析得出结果并通过信息化方式反馈给筛查医生，具有高效、准确和简便的优点。The risk model of gastrointestinal tumor incidence in this embodiment is trained by machine learning through a large amount of data, and these data can be collected in the form of network information questionnaires. To facilitate information collection, improve subject compliance and. To provide reliable data for statistical analysis, the online informatization questionnaire will be carried out by scanning the QR code. After the information is submitted, the server will analyze the result and feed it back to the screening doctor through informatization, which has the advantages of high efficiency, accuracy and simplicity.
可选地，所述使用消化道肿瘤发病风险模型对所述风险信息进行分析，估计消化道肿瘤危险因素的危险分值包括：根据所述生活质量信息，计算功能型分值和症状型分值，所述功能型分值用于反映所述目标对象的躯体功能、情绪功能、角色功能、认知功能、社会功能以及健康状况，所述症状型分值用于反映所述目标对象的机体症状；根据所述个体环境信息，计算个体环境分值；根据所述功能型分值、所述症状型分值和所述个体环境分值，计算所述危险分值。Optionally, analyzing the risk information by using a gastrointestinal tumor incidence risk model, and estimating the risk score of the gastrointestinal tumor risk factor includes: calculating a functional score and a symptom score according to the quality of life information. , the functional score is used to reflect the physical function, emotional function, role function, cognitive function, social function and health status of the target object, and the symptom score is used to reflect the body symptoms of the target object ; Calculate an individual environment score according to the individual environment information; calculate the risk score according to the functional type score, the symptom type score and the individual environment score.
可选地，所述个体环境信息还包括：身高、体重。Optionally, the individual environment information further includes: height and weight.
其中，所述根据所述个体环境信息，计算个体环境分值包括：根据所述饮食信息计算营养素摄入量，并确定所述营养素摄入量对应的第一分值；根据体力活动信息计算体力活动代谢当量，并确定所述体力活动代谢当量对应的第二分值；根据所述身高和所述体重计算身体质量指数，并确定所述身体质量指数对应的第三分值；根据所述第一分值、所述第二分值以及所述第三分值，得到所述个体环境分值。Wherein, calculating the individual environmental score according to the individual environmental information includes: calculating the nutrient intake according to the dietary information, and determining a first score corresponding to the nutrient intake; calculating physical strength according to the physical activity information activity metabolic equivalent, and determine the second score corresponding to the physical activity metabolic equivalent; calculate the body mass index according to the height and the weight, and determine the third score corresponding to the body mass index; A score, the second score, and the third score are obtained to obtain the individual environmental score.
步骤S103，根据所述危险分值，确定所述目标对象的消化道肿瘤发病风险。Step S103 , according to the risk score, determine the risk of gastrointestinal tumor of the target object.
发病风险的统计学分析是本发明方案的核心。为此，本实施例通过“消化道肿瘤发病风险评估系统”采集入组者的饮食、环境和体力活动等风险因素，应用自主构建的结构化消化道肿瘤数据库管理数据，使用队列人年、根据变量数量化包括膳食营养素、体力活动代谢当量以及烟酒茶摄入连续校正分析得出消化道肿瘤发病的相对风险(relative risk，RR)和消化道肿瘤综合危险度(odds ratio，OR)，用以评估受试者个体化的发病风险。Statistical analysis of morbidity risk is the core of the protocol of the present invention. To this end, in this example, risk factors such as diet, environment, and physical activity of participants were collected through the "gastrointestinal tumor risk assessment system", and the self-built structured digestive tract tumor database was used to manage the data. The quantification of variables including dietary nutrients, metabolic equivalents of physical activity, and continuous adjustment of intake of tobacco, alcohol, and tea was analyzed to obtain the relative risk (RR) of gastrointestinal tumors and the overall risk of gastrointestinal tumors (odds ratio, OR). to assess the individual risk of developing the disease.
可选地，所述根据所述危险分值，确定所述目标对象的消化道肿瘤发病风险包括：根据所述危险分值，确定风险等级；根据所述风险等级，得到所述目标对象的消化道肿瘤发病风险。Optionally, the determining the risk of gastrointestinal tumor of the target object according to the risk score includes: determining a risk level according to the risk score; obtaining the digestive tract tumor of the target object according to the risk level Risk of tract cancer.
具体地，根据危险分值可将消化道肿瘤筛查目标人群分为3个等级：高危人群，肿瘤发生风险极高；中危人群，有一定肿瘤发生风险；低危人群，肿瘤发生风险一般。Specifically, according to the risk score, the target population of digestive tract tumor screening can be divided into three levels: high-risk groups, with a very high risk of tumor occurrence; intermediate-risk groups, with a certain tumor risk; low-risk groups, with a moderate tumor risk.
本实施例中，通过获取目标对象的风险信息，风险信息至少包括：生活质量信息和个体环境信息；使用消化道肿瘤发病风险模型对风险信息进行分析，估计消化道肿瘤危险因素的危险分值，其中，消化道肿瘤发病风险模型为使用多组数据通过机器学习训练出的，多组数据中的每组数据均包括：风险信息和风险信息对应的危险分值；根据危险分值，确定目标对象的消化道肿瘤发病风险。从而能够基于地区性肿瘤发病风险特点，通过消化道肿瘤发病风险模型网络化高效应用，有针对性的进行筛查而提高消化道早期肿瘤检出率，提高患者的临床生存率。解决了现有技术中对消化道肿瘤的早期诊断率极低的问题。In this embodiment, by acquiring the risk information of the target object, the risk information at least includes: quality of life information and individual environment information; use the risk model of gastrointestinal tumor incidence to analyze the risk information, and estimate the risk score of gastrointestinal tumor risk factors, Among them, the risk model of gastrointestinal tumor incidence is trained by using multiple sets of data through machine learning, and each set of data in the multiple sets of data includes: risk information and the risk score corresponding to the risk information; according to the risk score, determine the target object risk of gastrointestinal tumors. Therefore, based on the characteristics of regional tumor incidence risk, the networked and efficient application of the gastrointestinal tumor incidence risk model can be used for targeted screening to improve the detection rate of early gastrointestinal tumors and improve the clinical survival rate of patients. The problem of extremely low early diagnosis rate of digestive tract tumors in the prior art is solved.
下面，对本实施例的消化道肿瘤发病风险评估方法进行详细说明：Below, the risk assessment method for gastrointestinal tumors in the present embodiment will be described in detail:
如图2所示，为本实施例的消化道肿瘤发病风险评估方法的流程图，具体方法如下：As shown in Figure 2, the flow chart of the risk assessment method for gastrointestinal tumors of the present embodiment, the specific method is as follows:
(1)研究队列及基线调查(1) Study cohort and baseline survey
使用自主设计的消化道肿瘤发病风险评估系统采集受试者资料，主要包括年龄、教育程度、家庭经济收入、疾病史、个人生活习惯史(如吸烟、饮酒、饮茶等)、饮食史、家族史、职业史、月经生育史、居住史、体力活动情况，以及在基线调查时测量的身高、体重指标。The self-designed risk assessment system for gastrointestinal tumors was used to collect the data of the subjects, mainly including age, education level, family income, disease history, personal life habit history (such as smoking, drinking, tea drinking, etc.), dietary history, family History, occupational history, menstrual and reproductive history, residence history, physical activity, and height and weight indicators measured at the baseline survey.
(2)身体指标测量(2) Physical index measurement
患者入组时均须使用校准的体重身高秤，根据标准方法测量调查对象的体重和身高，测量时要求被访者脱鞋、着单衣。体重测量使用数字电子秤，最小测量单位0.1kg(电子秤每个月进行1次校准)，身高的最小测量单位是0.1cm。每项指标均测量两次,如果两次测量读数超过容许误差(1cm或1kg)，则进行第三次测量,取最接近的两次测量值的平均值用于分析。从这些测量值产生以下变量:身体质量指数(body mass index，BMI)＝体重(kg)/身高(m)2All patients were required to use a calibrated weight-height scale to measure the weight and height of the respondents according to standard methods, and the respondents were required to take off their shoes and wear a single garment during the measurement. A digital electronic scale was used for weight measurement, the minimum measurement unit was 0.1 kg (the electronic scale was calibrated once a month), and the minimum measurement unit for height was 0.1 cm. Each indicator is measured twice. If the two measurement readings exceed the allowable error (1cm or 1kg), a third measurement is performed, and the average value of the closest two measurements is taken for analysis. The following variables were generated from these measurements: body mass index (BMI) = weight (kg)/height (m)2
(3)烟、酒、茶摄入评价(3) Tobacco, alcohol and tea intake evaluation
吸烟评价包括是否经常吸烟(每天至少1次,连续6个月以上)、开始吸烟的年龄、每天吸烟数量,以及停止吸烟的年龄。酒摄入评价包括是否经常饮酒(每周至少3次,连续6个月以上)、开始饮酒的年龄、过去一年中饮酒的品种(如啤酒、黄酒、葡萄酒、白酒)和数量，以及停止饮酒的年龄。茶摄入评价包括是否经常喝茶(每周至少3次,连续6个月以上)、开始喝茶的年龄、过去一年中饮茶的品种(如红茶、绿茶、乌龙茶、花茶)和数量，以及停止饮茶的年龄。Smoking evaluation included frequent smoking (at least once a day for more than 6 consecutive months), age of starting smoking, number of cigarettes smoked per day, and age of stopping smoking. Alcohol intake evaluation includes frequent drinking (at least 3 times a week for more than 6 consecutive months), age at which drinking started, type and quantity of drinking in the past year (such as beer, rice wine, wine, liquor), and cessation of drinking age. The evaluation of tea intake includes whether tea is often consumed (at least 3 times a week for more than 6 consecutive months), the age at which tea was started, the variety (such as black tea, green tea, oolong tea, scented tea) and quantity of tea consumed in the past year, and the age to stop drinking tea.
(4)食物频率问卷(FFQ)和体力活动问卷(PAQ)(4) Food Frequency Questionnaire (FFQ) and Physical Activity Questionnaire (PAQ)
本实施例采用的“消化道肿瘤发病风险评估系统”中包括可靠性和有效性检验的食物频率问卷(FoodFrequency Questionnaire，FFQ)，用以调查膳食营养素摄入情况。该问卷属于定量食物频率问卷,回忆期间为调查前一年，包括77项食物(组)，涵盖了主食、肉类、蛋类、鱼类、蔬菜、水果、豆制品、糕点及其它食物等几大类。食物分组主要考虑食物所含营养素的不同以及植物学分类或植物化学物质的不同。对于每种食物(组),调查对象都被询问单位时间内摄入频度(每天、每周、每月、每年的摄入次数)及每次食用量；季节性的食物同时询问上市时的食用情况以及一年中的平均食用月数,以便分析时对季节性食物的摄入量作出校正；鱼、肉、鸡、鸭等食物同时询问烹调方法。问卷还补充询问了调查对象近一年来每月在家进餐次数。本实施例采用的“消化道肿瘤发病风险评估系统”中的体力活动问卷(Physical Activity Questionnaire，PAQ)同样经过了可靠性和有效性检验。主要包括研究对象近5年参加体育锻炼、13-19岁期间参加体育锻炼(少部分人参加农活或工厂工作)和近1年的体力活动情况。近1年的体力活动情况主要包括以下几个方面：爬楼梯(层数)、家务劳动时间，上班以外的步行和骑自行车时间，以及与上下班或交通相关的步行、骑自行车、骑摩托车或助动车时间、乘车时间。The Food Frequency Questionnaire (FFQ) for reliability and validity testing is included in the "risk assessment system for gastrointestinal tumors" used in this example to investigate dietary nutrient intake. The questionnaire is a quantitative food frequency questionnaire. The recall period is the year before the survey. It includes 77 foods (groups), covering staple foods, meat, eggs, fish, vegetables, fruits, soy products, cakes and other foods. category. Food grouping mainly considers differences in nutrients contained in foods and differences in botanical classification or phytochemicals. For each food (group), the respondents were asked about the frequency of intake per unit time (number of intakes per day, week, month, and year) and the amount consumed each time; for seasonal foods, the The consumption situation and the average number of months of consumption in a year, so that the intake of seasonal food can be corrected for the analysis; the cooking methods of fish, meat, chicken, duck and other foods are also asked. The questionnaire also asked the respondents the number of meals they ate at home each month in the past year. The physical activity questionnaire (Physical Activity Questionnaire, PAQ) in the "risk assessment system for gastrointestinal tumors" adopted in this example has also been tested for reliability and validity. It mainly includes the subjects participating in physical exercise in the past 5 years, participating in physical exercise during the age of 13-19 (a small number of people participating in farm work or factory work), and physical activity in the past 1 year. Physical activity in the past 1 year mainly includes the following aspects: climbing stairs (number of floors), time for housework, time for walking and cycling outside work, and walking, cycling, and motorcycle riding related to commuting or transportation Or moped time, ride time.
(5)随访和数据录入(5) Follow-up and data entry
对被访者每两3个月进行一次电话回访，内容主要包括研究对象的发病、生存和失访情况以及上次回访后新发疾病的情况。通过本人和家属回答得到恶性肿瘤新发病例和死亡信息。对回访中发现的恶性肿瘤新病例，调查员再次回访获取详细的病史资料，并到其诊治医院摘录病史资料，请有关肿瘤临床专家复核各种资料以明确肿瘤的诊断。消化道肿瘤病例的分类编码按照国际疾病分类执行(ICD-9编码：153，154)。The respondents were interviewed by telephone every two to three months, and the contents mainly included the incidence, survival and loss to follow-up of the research subjects, as well as the situation of new diseases after the last return visit. Information on new cases and deaths of malignant tumors was obtained from the responses of the person and his/her family members. For new cases of malignant tumors discovered in the return visit, the investigators returned to visit again to obtain detailed medical history data, and went to their diagnosis and treatment hospital to extract the medical history data. Categorical coding of gastrointestinal tumor cases was performed according to the International Classification of Diseases (ICD-9 codes: 153, 154).
(6)内镜筛查(6) Endoscopy screening
由相同的医师在同一时间分别进行实验组和对照组的筛查，保证偏倚的最小化。Screening of the experimental and control groups was performed by the same physician at the same time to ensure minimal bias.
(7)质量控制(7) Quality control
本实施例中，现场调查员都经过统一严格的培训，以确保访问时语气态度一致，并减少诱发性的提问。征得被访者同意后，调查时采用现场录音，调查结束后由质量控制组工作人员随机抽取10％进行录音的复核，逐项检查调查表中每一个项目，以便能够及时发现、纠正错误和补充遗漏。随机抽取4％电话回访，核实信息及新地址等。质量控制的同时完成调查表的编码工作。并抽取10％比例己完成编码的调查表复查，以监督编码质量。为防止计算机人工录入的错误，所有的调查表都由不同计算机录入人员两次录入数据库,以保证数据资料的质量。研究者对资料中的每一个变量将进行范围和逻辑校对及初步分析，从而保证调查数据具有良好的逻辑关系和质量。所有研究对象在同意接受调查前均签署知情同意书。所有调查表中均有调查员、编码员等工作人员的签字或相关信息。In this embodiment, the on-site investigators have undergone uniform and strict training to ensure consistent tone and attitude during interviews and reduce provocative questions. After obtaining the consent of the respondents, on-site recordings were used during the investigation. After the investigation, the staff of the quality control team randomly selected 10% of the recordings to review the recordings, and checked each item in the questionnaire item by item, so as to detect and correct errors and problems in time. Supplementary omissions. Randomly select 4% of them to return by telephone to verify information and new addresses. The coding of the questionnaire was completed while the quality control was carried out. And select 10% of the questionnaires whose coding has been completed to review to supervise the quality of coding. In order to prevent the error of manual entry by computer, all questionnaires are entered into the database twice by different computer entry personnel to ensure the quality of data. The researcher will carry out scope and logical proofreading and preliminary analysis of each variable in the data, so as to ensure that the survey data has a good logical relationship and quality. All subjects signed an informed consent form before agreeing to be investigated. All questionnaires have the signatures or related information of investigators, coders and other staff.
本实施例所研究的人群：The population studied in this example:
1、录入标准1. Entry standard
(1)年龄介于18-80岁之间；(1) The age is between 18-80 years old;
(2)签署知情同意书；(2) Sign the informed consent;
(3)完成网络信息化风险因素收集；(3) Complete the collection of network informatization risk factors;
(4)BMI≥18kg/m2(4)BMI≥18kg/m2
2、排除标准2. Exclusion criteria
(1)还有其他系统恶性肿瘤或1年内曾经接受过化学治疗或放射治疗；(1) There are other systemic malignant tumors or have received chemotherapy or radiation therapy within 1 year;
(2)曾经接受腹腔内脏器切除手术；(2) Have received intra-abdominal organ resection;
(3)免疫缺陷病毒(HIV)感染、肝炎病毒感染；(3) Immunodeficiency virus (HIV) infection, hepatitis virus infection;
(4)患有高级别上皮内瘤变；(4) suffering from high-grade intraepithelial neoplasia;
(5)女性妊娠或哺乳；(5) Women are pregnant or breastfeeding;
(6)患有任何疾病包括但不限于，正在进行的或活动性感染，有症状的充血性心力衰竭、心绞痛、心律失常或精神疾病；或任何研究者认为可能会增加治疗相关的风险，或存在干扰研究结果的可能。(6) Suffering from any disease including, but not limited to, ongoing or active infection, symptomatic congestive heart failure, angina, arrhythmia or psychiatric illness; or any investigator that may increase the risk associated with treatment, or There is a potential for interference with the results of the study.
3、研究对象终止或者退出研究的标准3. Criteria for study subjects to terminate or withdraw from the study
(1)未完成问卷提交或问卷无效；(1) The questionnaire submission is not completed or the questionnaire is invalid;
(2)中途要求退出。(2) Request to quit midway.
4、研究分组4. Research group
本项研究受试者随机分为2组：The subjects of this study were randomly divided into 2 groups:
(1)基于个体化发病风险的筛查组(1) Screening group based on individualized risk of disease
(2)无发病风险的对照筛查组(2) Control screening group with no risk of disease
5、研究终点及其评价指标5. Study endpoints and their evaluation indicators
(1)主要研究终点：腺瘤检出率/高级别上皮内瘤变检出率；(1) Primary endpoint: adenoma detection rate/high-grade intraepithelial neoplasia detection rate;
(2)次要研究终点：息肉检出率/低级别上皮内瘤变检出率。(2) Secondary endpoint: polyp detection rate/low-grade intraepithelial neoplasia detection rate.
6、研究步骤6. Research steps
(1)受试者入组；(1) Subjects are enrolled;
(2)随机化分组；(2) Randomized grouping;
(3)网络信息化发病风险因素收集、分析；(3) Collection and analysis of risk factors for the onset of network information technology;
(4)风险反馈；(4) Risk feedback;
(5)内镜筛查、资料的收集和随访；(5) Endoscopy screening, data collection and follow-up;
(6)质量控制；(6) Quality control;
(7)资料的整理和分析。(7) Arrangement and analysis of data.
7、统计分析7. Statistical analysis
(1)样本量估计(1) Estimation of sample size
确定如下样本量估算参数：检验水准α为0.05，检验效能1-β为0.90，Jag1含量为定量变量。采用样本量估算专门软件PASS11.0，按照Logistic回归模型/Cox回归模型计算所需样本量，结果为各组需要1760例。The following sample size estimation parameters were determined: the test level α was 0.05, the test power 1-β was 0.90, and the Jag1 content was a quantitative variable. PASS11.0, a special software for sample size estimation, was used to calculate the required sample size according to the Logistic regression model/Cox regression model. The result was 1760 cases in each group.
(2)数据分析计划(2) Data analysis plan
(a)人年计算(a) Person-year calculation
队列人年的计算根据医学统计学的方法，以个人为单位。其中高危结肠癌肥胖人群和结肠癌病例的随访人年为进入队列开始日期到结直肠癌诊断日期为止的时间间隔；失访或死亡对象的随访人年为从该对象进入队列开始日期到最后一次随访或死亡为止的时间间隔；其它成员的随访人年为其进入队列的开始日期到本次研究的截止日期为止的时间间隔。The cohort person-years are calculated according to the methods of medical statistics, and the unit is individual. Among them, the follow-up person-years of high-risk colon cancer obese people and colon cancer cases are the time interval from the start date of entering the cohort to the date of diagnosis of colorectal cancer; the follow-up person-years of the lost or dead subjects are from the start date of the subject entering the cohort to the last time Time interval until follow-up or death; follow-up person-years for other members were the time interval from the start date of entry into the cohort to the cut-off date of this study.
(b)变量数量化(b) Quantification of variables
根据变量数量化理论,将定性的调查指标转化成分组变量，用(0,1)法数量化；连续性变量根据五分位数(部分变量采用国际或国内常用的划分标准)划分为R个水平的等级变量，并设立参比组(通常为该因素的非暴露组或最低暴露组)，产生R-1个哑变量；除估计一其它各组的相对危险度及其95％置信区间(CI)外，对存在自然顺序的有序变量作为连续性变量进入模型，并作趋势检验以判定是否存在剂量反应关系。According to the theory of quantification of variables, the qualitative survey indicators are converted into group variables and quantified by the (0,1) method; continuous variables are divided into R groups according to quintiles (part of the variables adopt the international or domestic commonly used classification standards) level variable, and set up a reference group (usually the non-exposed group or the lowest exposure group for the factor), resulting in R-1 dummy variable; in addition to estimating the relative risk of each other group and its 95% confidence interval ( In addition to CI), ordinal variables with natural order are entered into the model as continuous variables, and trend tests are performed to determine whether there is a dose-response relationship.
(c)营养素摄入的计算(c) Calculation of Nutrient Intake
食物和营养素之间的折算根据公式为：The conversion between food and nutrients is based on the formula:
其中，N为某营养素摄入量，F为某食物项摄入量(克)，P为食部(食部为每100克食品的可食用部分)，A为食部100克中该营养素的含量。能量的调整采用对数转换回归残差法[3',“5],以排除总能量的影响。残差法又称为能量校正法，主要是以总能量摄入为自变量，以某种食物或营养素摄入为应变量作回归分析，求得的残差即排除了总能量的影响。由于残差包含负数，不易理解，因此常将营养素残差与一个常数相加,这个常数一般取研究人群平均能量摄入的期望营养素摄入量。Among them, N is the intake of a certain nutrient, F is the intake of a certain food item (grams), P is the food portion (the food portion is the edible part per 100 grams of food), and A is the nutrient in 100 grams of the food portion. content. The energy adjustment adopts the logarithmic transformation regression residual method [3', "5] to exclude the influence of the total energy. The residual method, also known as the energy correction method, mainly uses the total energy intake as the independent variable, with a certain Food or nutrient intake is used as the dependent variable for regression analysis, and the obtained residual excludes the influence of total energy. Since the residual contains negative numbers, it is difficult to understand, so the nutrient residual is often added to a constant, which is generally taken as Expected nutrient intake for mean energy intake in the study population.
(d)体力活动代谢当量(MET)的计算(d) Calculation of Metabolic Equivalents (MET) of Physical Activity
每位研究对象体力活动的水平或强度大小按体力活动问卷(PAQ)中获得的信息，用体力活动代谢当量(metabolic equivalents,MET)来衡量。能量代谢当量是以安静、坐位时能量消耗为基础，表达各种活动时相对能量代谢水平的常用指标。定义为每公斤体重从事1分钟活动,消耗3.5毫升的氧气,这样的运动强度为1个MET。此次研究结合了调查对象的人口统计学特点,对体育活动和日常活动等体力活动分别赋予相应MET值。每周MET值计算公式如下：The level or intensity of physical activity of each subject was measured by the physical activity metabolic equivalents (MET) according to the information obtained from the Physical Activity Questionnaire (PAQ). The energy metabolism equivalent is a common indicator that expresses the relative energy metabolism level of various activities based on the energy consumption in a quiet and sitting position. It is defined as 1 minute of activity per kilogram of body weight, consuming 3.5 ml of oxygen, and the intensity of such exercise is 1 MET. This study combines the demographic characteristics of the survey subjects, and assigns corresponding MET values to physical activities such as physical activities and daily activities. The formula for calculating the weekly MET value is as follows:
MET＝∑METn×hnMET=∑METn×hn
其中，METn为特定PA类型(种类)的代谢当量，hn为相应活动时间。主要计算休闲体育活动、日常体力活动和所有体力活动每周代谢当量总量。Among them, METn is the metabolic equivalent of a specific PA type (species), and hn is the corresponding activity time. Mainly calculates recreational physical activity, daily physical activity, and total weekly metabolic equivalents of all physical activity.
(e)相对危险度的估计(e) Estimation of relative risk
用Cox比例风险模型估计各结直肠癌危险因素的相对危险度(relative risk，RR)及其95％置信区间(confidence interval，CI)。所有统计学检验均采用双侧检验，P<0.05被认为是有统计学意义的。Cox回归分析是广泛用于生存资料分析的半参数回归分析方法。Cox比例风险回归模型的一般形式：The relative risk (RR) and 95% confidence interval (CI) of each colorectal cancer risk factor were estimated by Cox proportional hazards model. All statistical tests were two-sided, and P<0.05 was considered statistically significant. Cox regression analysis is a semiparametric regression analysis method widely used in the analysis of survival data. The general form of the Cox proportional hazards regression model:
h(t)＝h0(t)exp(β*zi)h(t)=h0 (t)exp(β*zi )
其中：hi(t)为t时刻的风险函数；h0(t)为基准风险函数；β为回归系数向量；zi为第i个观测对象的自变量向量。回归系数β的估计采用最大偏似然法估计,回归系数的检验采用waldχ2检验。Among them: hi(t) is the risk function at time t; h0(t) is the benchmark risk function; β is the regression coefficient vector; zi is the independent variable vector of the i-th observation object. The regression coefficient β was estimated by the maximum partial likelihood method, and the regression coefficient was tested by the wald χ2 test.
进一步地，本实施例使用QLQ-c30问卷综合了症状因素还整合了保护因素，即除了累加分数，还有减分。具体问卷如下：Further, in this embodiment, the QLQ-c30 questionnaire is used to integrate both symptom factors and protective factors, that is, in addition to accumulating scores, there are also deductions. The specific questionnaires are as follows:
基础信息部分Basic Information Section
1.您的姓名1. Your name
2.您的性别是？2. What is your gender?
男2分Male 2 points
女0分Female 0 points
3.您的出生年份是？3. What is your birth year?
0-49岁0分0-49 years old 0 points
50-59岁7分50-59 years old 7 points
60-69岁9分60-69 years old 9 points
>69岁12分>69 years and 12 minutes
4.您的ID号、患者编号或住院号是？4. What is your ID number, patient number or hospital number?
5.您的手机号码5. Your mobile number
QLQ-C30生活质量信息QLQ-C30 Quality of Life Information
对下列问题，答案并无“对”与“不对”之分，只要求您在1-4之间选择最能反映您情况的那个数字。There is no "yes" or "no" answer to the following questions, you are only asked to choose the number between 1-4 that best reflects your situation.
1.您从事一些费力的活动有困难吗，比如说提很重的购物袋或手提箱？1. Do you have difficulty with strenuous activities, such as carrying heavy shopping bags or suitcases?
1～41 to 4
2.长距离行走对您来说有困难吗？2. Is it difficult for you to walk long distances?
1～41 to 4
3.户外短距离行走对您来说有困难吗？3. Is it difficult for you to walk short distances outdoors?
1～41 to 4
4.您白天需要呆在床上或椅子上吗？4. Do you need to stay in bed or chair during the day?
1～41 to 4
5.您在吃饭、穿衣、洗澡或上厕所时需要他人帮忙吗？5. Do you need help with eating, dressing, bathing or going to the toilet?
1～41 to 4
对下列问题，请在1-4之间选出一个最适合您的数字在过去的一星期内：For the following questions, please choose a number from 1-4 that worked best for you in the past week:
6.您在工作和日常活动中是否受到限制？6. Are you restricted in your work and daily activities?
1～41 to 4
7.您在从事您的爱好或休闲活动时是否受到限制？7. Are you restricted in your hobbies or leisure activities?
1～41 to 4
8.您有气促吗？8. Are you short of breath?
1～41 to 4
9.您有疼痛吗？9. Do you have pain?
1～41 to 4
10.您需要休息吗？10. Do you need a break?
1～41 to 4
11.您睡眠有困难吗？11. Do you have trouble sleeping?
1～41 to 4
12.您觉得虚弱吗？12. Do you feel weak?
1～41 to 4
13.您食欲不振(没有胃口)吗？13. Do you have a loss of appetite (no appetite)?
1～41 to 4
14.您曾感觉恶心吗？14. Have you ever felt sick?
1～41 to 4
15.您曾呕吐过吗？15. Have you ever vomited?
1～41 to 4
16.您曾有便秘吗？16. Have you ever had constipation?
1～41 to 4
17.您曾有腹泻吗？17. Have you ever had diarrhea?
1～41 to 4
18.您觉得累吗？18. Are you tired?
1～41 to 4
19.疼痛影响您的日常活动吗？19. Does pain interfere with your daily activities?
1～41 to 4
20.您集中精力做事有困难吗，如读报纸或看电视？20. Do you have trouble concentrating on things, such as reading the newspaper or watching TV?
1～41 to 4
21.您觉得紧张吗？21. Do you feel nervous?
1～41 to 4
22.您觉得忧虑吗？22. Do you feel anxious?
1～41 to 4
23.您觉得脾气急躁吗？23. Do you feel short-tempered?
1～41 to 4
24.您觉得压抑(情绪低落)吗？24. Do you feel depressed (depressed)?
1～41 to 4
25.您感到记忆困难吗？25. Do you have trouble remembering?
1～41 to 4
26.您的身体状况或治疗影响您的家庭生活吗？26. Does your medical condition or treatment affect your family life?
1～41 to 4
27.您的身体状况或治疗影响您的社交活动吗？27. Does your medical condition or treatment affect your social activities?
1～41 to 4
28.您的身体状况或治疗使您陷入经济困难吗？28. Has your medical condition or treatment put you in financial hardship?
1～51 to 5
对下列问题，请在1-7之间选出一个最适合您的数字。For the following questions, please choose a number between 1-7 that best suits you.
29.您如何评价在过去一星期内您总的健康情况？29. How would you rate your general health over the past week?
1～71 to 7
30.您如何评价在过去一星期内您总的生命质量？30. How would you rate your overall quality of life over the past week?
1～71 to 7
危险分值评分方法：Risk score scoring method:
功能型functional
躯体功能(Q1+Q2+Q3+Q4+Q5)/5Physical function (Q1+Q2+Q3+Q4+Q5)/5
角色功能(Q6+Q7)/2Role function (Q6+Q7)/2
情绪功能(Q21+Q22+Q23+Q24)/4Emotional function (Q21+Q22+Q23+Q24)/4
认知功能(Q20+Q25)/2Cognitive function (Q20+Q25)/2
社会功能(Q26+Q27)/2Social function (Q26+Q27)/2
总健康状况(Q29+Q30)/2Total health status (Q29+Q30)/2
症状型symptomatic
疲倦(Q10+Q12+Q18)/3Tired (Q10+Q12+Q18)/3
恶心与呕吐(Q14+Q15)/2>21分Nausea and vomiting (Q14+Q15)/2>21 points
疼痛(Q9+Q19)/2>21分Pain (Q9+Q19)/2>21 points
气促Q8Shortness of breath Q8
失眠Q11Insomnia Q11
食欲丧失Q13>21分Appetite loss Q13>21 points
便秘Q16>21分Constipation Q16>21 points
腹泻Q17>21分Diarrhea Q17>21 points
经济困难Q28>21分Economic difficulties Q28>21 points
个体环境信息部分Individual Environmental Information Section
1.您的身高是？(厘米)1. What is your height? (centimeter)
2.您的体重是？(公斤)2. What is your weight? (Kilogram)
BMI＝体重(公斤)/身高(米)2BMI = weight (kg) / height (m)2
BMI<23.00分BMI<23.00 points
23.0≤BMI<27.52分23.0≤BMI<27.52 points
BMI≥27.54分BMI≥27.54 points
2.您是否吸烟？2. Do you smoke?
是，吸烟超过1年，每天至少1支3分Yes, smoked for more than 1 year, at least 1 cigarette per day 3 points
否0分No 0 points
是，但已经戒烟1分Yes, but quit smoking 1 point
4.您是否饮酒？4. Do you drink alcohol?
是，饮酒超过6个月，每周超过6瓶啤酒、或半斤白酒、或4大杯葡萄酒2分Yes, drinking more than 6 months, more than 6 bottles of beer, or half a catty of liquor, or 4 large glasses of wine 2 points per week
是，但饮酒量不达以上标准1分Yes, but the alcohol consumption does not meet the above standard 1 point
是，但已经戒酒0分Yes, but have quit drinking 0 points
否0分No 0 points
5.您是否喜好饮茶？5. Do you like drinking tea?
是，每日饮茶-2分Yes, daily tea - 2 points
是，偶尔饮茶-1分Yes, occasional tea - 1 point
否0分No 0 points
6.您是否喜好食辣？6. Do you like spicy food?
是，每日食辣1分Yes, 1 point of spicy food every day
是，偶尔食辣0分Yes, occasionally spicy food 0 points
否0分No 0 points
7.您平时的主要主食种类？7. What is your main staple food?
米饭rice
面食pasta
米饭面食基本均等Rice pasta basically equal
8.您平均每日有几次正餐和加餐食用了充足的(超过200克)蔬菜或水果？8. On average, how many times a day do you eat enough (over 200 grams) of vegetables or fruits for regular meals and snacks?
0(2分)0 (2 points)
1(1分)1 (1 point)
2(0分)2 (0 points)
3(-1分)3 (-1 point)
4(-2分)4 (-2 points)
5及以上(-3分)5 and above (-3 points)
9.您平均每日食用多少腌制加工肉制品(香肠、火腿等)？9. How much cured and processed meat products (sausage, ham, etc.) do you consume on average per day?
从不食用0分never eat 0 points
偶尔食用1分Occasionally eat 1 point
每日食用，但少于50克2分Consume daily, but less than 50 grams 2 points
每日食用超过50克3分Consume more than 50 grams per day for 3 points
10.下列药品是否有您曾经或正在使用的(可多选)？10. Have you ever used or are using the following medicines (multiple choice)?
阿司匹林类任何选项(除以上均无外)-1分(多选只记-1分)Any option of aspirin (except none of the above) - 1 point (multiple choices are only recorded - 1 point)
他汀类statins
维生素类vitamins
钙剂calcium
胰岛素insulin
口服降糖药物Oral hypoglycemic drugs
降压药物antihypertensive drugs
益生菌制剂Probiotics
以上均无None of the above
11.您通常是否每日久坐超过4小时？11. Are you usually sedentary for more than 4 hours a day?
是2分is 2 points
否0分No 0 points
12.您通常每周有多少天在交通中步行或骑自行车至少持续10分钟以上？12. How many days a week do you typically walk or cycle in traffic for at least 10 minutes or more?
0(1分)0 (1 point)
1(1分)1 (1 point)
2(1分)2 (1 point)
3(0分)3 (0 points)
4(0分)4 (0 points)
5(-1分)5 (-1 point)
6(-1分)6 (-1 point)
7(-1分)7 (-1 point)
13.你通常每周有多少天进行中等强度的运动、健身和娱乐性(休闲)体力活动？13. How many days per week do you typically engage in moderate-intensity physical activity, fitness, and recreational (recreational) physical activity?
0(2分)0 (2 points)
1(1分)1 (1 point)
2(0分)2 (0 points)
3(-1分)3 (-1 point)
4(-1分)4 (-1 point)
5(-1分)5 (-1 point)
6(-2分)6 (-2 points)
7(-2分)7 (-2 points)
14.您是否有幽门螺旋杆菌感染？14. Do you have Helicobacter pylori infection?
否0分No 0 points
是，尚未治疗4分Yes, not yet treated 4 points
是，但已经根除1分Yes, but 1 point has been eradicated
是，根除治疗失败3分Yes, eradication therapy failure 3 points
不详1分Unknown 1 point
15.您是否有直系亲属确诊为消化道恶性肿瘤题干更改15. Do you have any immediate family members who have been diagnosed with malignant tumors of the digestive tract?
是5分is 5 points
否0分No 0 points
不详0分Unknown 0 points
16.您是否有直系亲属体重超重或肥胖16. Do you have an immediate family member who is overweight or obese
是1分is 1 point
否0分No 0 points
不详0分Unknown 0 points
最低0分最高50分Minimum 0 points Maximum 50 points
根据分值可将筛查目标人群分为3个等级：According to the score, the screening target population can be divided into 3 levels:
·高危人群(36-50分)，肿瘤发生风险极高；·High-risk group (36-50 points), the risk of tumor occurrence is extremely high;
·中危人群(19-35分)，有一定肿瘤发生风险；·Intermediate risk group (19-35 points), there is a certain risk of tumor occurrence;
·低危人群(0-18分)，肿瘤发生风险一般。·Low-risk group (0-18 points), the risk of tumor occurrence is average.
实施例2Example 2
根据本发明实施例的消化道肿瘤发病风险评估系统，如图3所示，包括：The risk assessment system for gastrointestinal tumors according to an embodiment of the present invention, as shown in FIG. 3 , includes:
获取模块30，用于获取目标对象的风险信息，所述风险信息至少包括：生活质量信息和个体环境信息；an acquisition module 30, configured to acquire risk information of the target object, where the risk information at least includes: life quality information and individual environment information;
分析模块31，与所述获取模块30连接，用于使用消化道肿瘤发病风险模型对所述风险信息进行分析，估计消化道肿瘤危险因素的危险分值，其中，所述消化道肿瘤发病风险模型为使用多组数据通过机器学习训练出的，所述多组数据中的每组数据均包括：风险信息和风险信息对应的危险分值；An analysis module 31, connected with the acquisition module 30, is used to analyze the risk information by using a risk model for the incidence of gastrointestinal tumors, and estimate the risk score of the risk factors for gastrointestinal tumors, wherein the risk model for the incidence of tumors in the gastrointestinal tract To be trained by using multiple sets of data through machine learning, each set of data in the multiple sets of data includes: risk information and a risk score corresponding to the risk information;
处理模块32，与所述分析模块31连接，用于根据所述危险分值，确定所述目标对象的消化道肿瘤发病风险。The processing module 32 is connected to the analysis module 31, and is configured to determine the risk of gastrointestinal tumor of the target object according to the risk score.
应用本发明技术方案的消化道肿瘤发病风险评估系统，包括获取模块，用于获取目标对象的风险信息；分析模块，与所述获取模块连接，用于使用消化道肿瘤发病风险模型对所述风险信息进行分析，估计消化道肿瘤危险因素的危险分值；处理模块，与所述分析模块连接，用于根据所述危险分值，确定所述目标对象的消化道肿瘤发病风险。从而能够基于地区性肿瘤发病风险特点，通过消化道肿瘤发病风险模型网络化高效应用，有针对性的进行筛查而提高消化道早期肿瘤检出率，提高患者的临床生存率。解决了现有技术中对消化道肿瘤的早期诊断率极低的问题。A digestive tract tumor incidence risk assessment system applying the technical solution of the present invention includes an acquisition module for acquiring risk information of a target object; an analysis module, connected with the acquisition module, for using a digestive tract tumor incidence risk model to evaluate the risk The information is analyzed to estimate the risk score of the risk factors of digestive tract tumor; the processing module is connected with the analysis module, and is used for determining the risk of digestive tract tumor of the target object according to the risk score. Therefore, based on the characteristics of regional tumor incidence risk, the networked and efficient application of the gastrointestinal tumor incidence risk model can be used for targeted screening to improve the detection rate of early gastrointestinal tumors and improve the clinical survival rate of patients. The problem of extremely low early diagnosis rate of digestive tract tumors in the prior art is solved.
可选地，所述生活质量信息至少包括：日常活动质量信息、睡眠质量信息、疾病信息、精神状况、经济状况、社交状况；所述个体环境信息至少包括：身高、体重、饮食信息、体力活动信息、家族信息。Optionally, the quality of life information includes at least: daily activity quality information, sleep quality information, disease information, mental status, economic status, and social status; the individual environmental information includes at least: height, weight, diet information, physical activity information, family information.
可选地，所述分析模块用于执行以下步骤使用消化道肿瘤发病风险模型对所述风险信息进行分析，估计消化道肿瘤危险因素的危险分值：根据所述生活质量信息，计算功能型分值和症状型分值，所述功能型分值用于反映所述目标对象的躯体功能、情绪功能、角色功能、认知功能、社会功能以及健康状况，所述症状型分值用于反映所述目标对象的机体症状；根据所述个体环境信息，计算个体环境分值；根据所述功能型分值、所述症状型分值和所述个体环境分值，计算所述危险分值。Optionally, the analysis module is configured to perform the following steps to analyze the risk information using a gastrointestinal tumor incidence risk model, and estimate the risk score of the risk factors for gastrointestinal tumors: calculating a functional score according to the quality of life information. value and symptom score, the functional score is used to reflect the physical function, emotional function, role function, cognitive function, social function and health status of the target object, and the symptom score is used to reflect all the The body symptoms of the target object; according to the individual environment information, the individual environment score is calculated; the risk score is calculated according to the functional type score, the symptom type score and the individual environment score.
可选地，所述个体环境信息还包括：身高、体重；其中，所述分析模块用于执行以下步骤根据所述个体环境信息，计算个体环境分值：根据所述饮食信息计算营养素摄入量，并确定所述营养素摄入量对应的第一分值；根据体力活动信息计算体力活动代谢当量，并确定所述体力活动代谢当量对应的第二分值；根据所述身高和所述体重计算身体质量指数，并确定所述身体质量指数对应的第三分值；根据所述第一分值、所述第二分值以及所述第三分值，得到所述个体环境分值。Optionally, the individual environmental information further includes: height and weight; wherein, the analysis module is configured to perform the following steps to calculate the individual environmental score according to the individual environmental information: calculate the nutrient intake according to the dietary information , and determine the first score corresponding to the nutrient intake; calculate the physical activity metabolic equivalent according to the physical activity information, and determine the second score corresponding to the physical activity metabolic equivalent; calculate according to the height and the weight body mass index, and determine a third score corresponding to the body mass index; and obtain the individual environment score according to the first score, the second score, and the third score.
可选地，所述处理模块用于执行以下步骤根据所述危险分值，确定所述目标对象的消化道肿瘤发病风险：根据所述危险分值，确定风险等级；根据所述风险等级，得到所述目标对象的消化道肿瘤发病风险。Optionally, the processing module is configured to perform the following steps to determine the gastrointestinal tumor incidence risk of the target object according to the risk score: to determine a risk level according to the risk score; to obtain according to the risk level. The risk of gastrointestinal tumors of the target subject.
以上所述仅为本发明的优选实施例而已，并不用于限制本发明，对于本领域的技术人员来说，本发明可以有各种更改和变化。凡在本发明的精神和原则之内，所作的任何修改、等同替换、改进等，均应包含在本发明的保护范围之内。The above descriptions are only preferred embodiments of the present invention, and are not intended to limit the present invention. For those skilled in the art, the present invention may have various modifications and changes. Any modification, equivalent replacement, improvement, etc. made within the spirit and principle of the present invention shall be included within the protection scope of the present invention.
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201910577388.4ACN110310742A (en) | 2019-06-28 | 2019-06-28 | Methods and systems for risk assessment of gastrointestinal tumors |
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201910577388.4ACN110310742A (en) | 2019-06-28 | 2019-06-28 | Methods and systems for risk assessment of gastrointestinal tumors |
| Publication Number | Publication Date |
|---|---|
| CN110310742Atrue CN110310742A (en) | 2019-10-08 |
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201910577388.4APendingCN110310742A (en) | 2019-06-28 | 2019-06-28 | Methods and systems for risk assessment of gastrointestinal tumors |
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| CN (1) | CN110310742A (en) |
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN111312405A (en)* | 2020-02-12 | 2020-06-19 | 宁德市闽东医院 | Health examination gastric cancer screening, evaluating and managing system |
| CN112133369A (en)* | 2020-08-26 | 2020-12-25 | 吴安华 | A system for evaluating the prognosis of tumor patients based on reactive oxygen species and a method for evaluating and improving drug sensitivity |
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| RJ01 | Rejection of invention patent application after publication | Application publication date:20191008 |