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CN109925612A - Neutron capture treatment system - Google Patents

Neutron capture treatment system
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Publication number
CN109925612A
CN109925612ACN201711365076.4ACN201711365076ACN109925612ACN 109925612 ACN109925612 ACN 109925612ACN 201711365076 ACN201711365076 ACN 201711365076ACN 109925612 ACN109925612 ACN 109925612A
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China
Prior art keywords
neutron
collimator
axis
wall
treatment system
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Granted
Application number
CN201711365076.4A
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Chinese (zh)
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CN109925612B (en
Inventor
刘渊豪
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Neuboron Medtech Ltd
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Neuboron Medtech Ltd
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Priority to CN201711365076.4ApriorityCriticalpatent/CN109925612B/en
Priority to JP2020530385Aprioritypatent/JP6947934B2/en
Priority to EP18890061.7Aprioritypatent/EP3708225B1/en
Priority to PCT/CN2018/100987prioritypatent/WO2019119835A1/en
Publication of CN109925612ApublicationCriticalpatent/CN109925612A/en
Priority to US16/880,125prioritypatent/US11583701B2/en
Priority to US18/098,161prioritypatent/US20230277872A1/en
Application grantedgrantedCritical
Publication of CN109925612BpublicationCriticalpatent/CN109925612B/en
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Abstract

The application provides a kind of neutron capture treatment system, the neutron capture treatment system includes neutron generating unit, exposure cell, it preparation room and is set to the exposure cell and described prepares indoor auxiliary locator, the neutron beam generating unit includes the accelerator for accelerating charged particle beam, the neutron beam generating unit for generating neutron beam and the Transport of Charged Particle Beams portion that charged particle beam is used for transmission between accelerator and neutron beam generating unit are reacted with charged particle beam, exposure cell is the room for irradiating neutron beam to irradiated body, preparation room is the room for the preparation needed for implementing before irradiating neutron beam to illuminated person, the auxiliary locator is equipped with laser emitter of the transmitting laser beam to be positioned to illuminated person, the position of the laser emitter is selectable, therefore irradiated body can be implemented under any circumstance Precisely irradiation is realized in positioning.

Description

Neutron capture treatment system
Technical field
The present invention relates to a kind of radioactive ray irradiation system more particularly to a kind of neutron capture treatment systems.
Background technique
As the radiation cures such as the development of atomics, such as cobalt 60, linear accelerator, electron beam have become cancerOne of the main means of disease treatment.However conventional photonic or electronic therapy are limited by radioactive ray physical condition itself, are being killedWhile dead tumour cell, normal tissue a large amount of in beam approach can also be damaged;Additionally, due to tumour cell to puttingThe difference of radiation-sensitive degree, traditional radiation therapy is for relatively having the malignant tumour of radiation resistance (such as: multirow glioblastTumor
(glioblastoma multiforme), melanocytoma (melanoma)) treatment effect it is often bad.
Target therapy in order to reduce the radiation injury of tumour surrounding normal tissue, in chemotherapy (chemotherapy)Concept is just applied in radiation cure;And it is directed to the tumour cell of radiation resistance, also actively development has high phase at presentTo the radiation source of biological effect (relative biological effectiveness, RBE), as proton therapeutic, heavy particle are controlledTreatment, neutron capture treatment etc..Wherein, neutron capture treatment is to combine above two concept, if boron neutron capture is treated, byBoracic drug gathers in the specificity of tumour cell, and accurately neutron beam irradiates for cooperation, provides more better than conventional radiationTreatment of cancer selection.
To realize, accurately neutron beam irradiates, and in preparation room, needs to combine laser orientation system pair by CT images etc.The knub position of patient is accurately positioned and makes marks, and in exposure cell, needs to be incorporated in preparation by laser orientation systemThe label that room is done, which carries out positioning to patient, is irradiated neutron beam to prospective tumor.Traditional laser orientation system includes four and swashsOptical transmitting set is fixedly installed in respectively on preparation room and the wall and ceiling of exposure cell, due to laser emitter be it is fixed,When the objects such as preparation room and/or the indoor perfusion tube of irradiation, therapeutic bed shelter from laser beam, then it is difficult to carry out essence to patientCertainly position, so that accurately neutron beam irradiation treatment can not be implemented.
Summary of the invention
To solve the above-mentioned problems, one embodiment of the application provides a kind of neutron capture treatment system comprising inSub- generating unit, exposure cell, preparation room and be set to the exposure cell and it is described prepare indoor auxiliary locator, exposure cell is to useIn the room to irradiated body irradiation neutron beam, exposure cell is equipped with the first shielding wall, and the first shielding wall is equipped with for neutron beamCollimator out, neutron beam is projected from collimator limits a neutron beam axis, and preparation room is for implementing to illuminated personThe room of preparation needed for before irradiation neutron beam, auxiliary locator are equipped with transmitting laser beam to determine illuminated personThe laser emitter of position, the position of laser emitter is selectable.
Compared with prior art, the technical solution that the present embodiment is recorded has the advantages that the position of laser emitterSetting can be selectable, therefore can implement to position to irradiated body under any circumstance, realizes precisely irradiation.
Further, auxiliary locator includes pedestal and from the vertically extending cantilever of pedestal, and laser emitter setting is outstandingOn arm.
Preferably, laser emitter is set as one, and cantilever is equipped with for the mobile guide rail of laser emitter and by laserTransmitter is fixed on the locating piece of selected location.
Preferably, laser emitter is set as one, and cantilever is extension type cantilever.
Preferably, laser emitter is set as multiple, and multiple laser emitters are from close to end of the cantilever far from pedestalPosition is arranged successively.
Further, preparation room is equipped with the first wall, and the first wall is equipped with identical with the structure and size of collimatorCollimator model, auxiliary locator is arranged and is installed on the first shielding wall and/or the around collimator and/or collimator modelOn one wall.
Further, preparation room is equipped with the first wall, and the first wall is equipped with identical with the structure and size of collimatorCollimator model, auxiliary locator is installed on collimator and/or collimator model.
Preferably, neutron generating unit includes for accelerating the accelerator of charged particle beam, reacting generation with charged particle beamThe neutron beam generating unit of neutron beam and the band electrochondria that charged particle beam is used for transmission between accelerator and neutron beam generating unitBeamlet transport part.
Preferably, pedestal and cantilever are rectangular shape, are respectively equipped on the first shielding wall and the first wall around collimationDevice, the setting of collimator model and the fixed part that auxiliary locator is fixed, positioning region, set XYZ coordinate, Y-axis is parallel toNeutron beam axis, Z axis are the direction vertical relative to ground, and X-axis is the direction orthogonal with Y-axis and Z axis, and fixed part includes positionRight above the collimator and the first fixed part of paralleled by X axis direction arrangement, on the left of collimator and it is parallel to the of axis arrangementTwo fixed parts and on the right side of the collimator and it is parallel to the third fixed part of Z axis arrangement;Positioning region includes and first, second,The first, second, third positioning region that three fixed parts are correspondingly arranged, the first, second, third fixed part and first, second, third are determinedThe structure and size in position portion correspond to identical;The central point of projection with collimator on the first shielding wall and collimator model respectivelyThe central point on the basis of point of projection on the first wall, then the central point of the first, second, third fixed part and first, second,The coordinate value of the central point of third positioning region corresponds to identical.
Preferably, pedestal is hollow cylindrical body, and cantilever is and the vertically disposed hexahedron of pedestal, the first shielding wall and theIt is respectively equipped with the fixed part that auxiliary locator is fixed, positioning region on one wall, sets XYZ coordinate, Y-axis is parallel to neutronBeam axis, Z axis are the direction vertical relative to ground, and X-axis is the direction orthogonal with Y-axis and Z axis, and fixed part and positioning region areRespectively with collimator at the center of the projection on the first wall of central point and collimator model of the projection on the first shielding wallPoint is the identical hollow circular ring of size in the center of circle.
Detailed description of the invention
Fig. 1 is the top view of the application neutron capture treatment system;
Fig. 2 is the schematic diagram that the exposure cell of positioning device is mounted in Fig. 1;
Fig. 3 is the schematic diagram that the preparation room of locating module is mounted in Fig. 1;
Fig. 4 is the perspective view of the auxiliary locator of the embodiment of the present application one;
Fig. 5 is the front view of the auxiliary locator in Fig. 5;
Fig. 6 is the schematic diagram of fixed part corresponding with the auxiliary locator in embodiment one in exposure cell;
Fig. 7 is the schematic diagram of positioning region corresponding with the auxiliary locator in embodiment one preparation room Nei;
Fig. 8 is the perspective view of the auxiliary locator of the embodiment of the present application two;
Fig. 9 is the schematic diagram of fixed part corresponding with the auxiliary locator in embodiment two in exposure cell;
Figure 10 is the schematic diagram of positioning region corresponding with the auxiliary locator in embodiment two preparation room Nei;
Specific embodiment
Neutron capture treatment as a kind of effective treating cancer means in recent years using gradually increasing, wherein with boronNeutron capture treatment is most commonly seen, and the neutron of supply boron neutron capture treatment can be by nuclear reactor, D-T accelerator for neutron production, D-DAccelerator for neutron production, spallation neutron target or accelerator supply.Embodiments herein adds by taking the treatment of accelerator boron neutron capture as an exampleThe basic module of fast device boron neutron capture treatment generally includes to add for accelerate charged particle (such as proton, deuteron)Fast device, neutron generating unit and hot removal system and beam-shaping body.Charged particle and metal neutron generating unit is wherein accelerated to makeWith neutron is generated, according in required neutron yield rate and energy, available acceleration charged particle energy and size of current, metalThe characteristics such as the materialization of sub- generating unit select suitable nuclear reaction.The nuclear reaction being often discussed has7Li(p,n)7Be and9Be(p,n)9B。
As shown in Figure 1, neutron capture treatment system 1 has neutron beam generating unit 2, use for generating treatment neutron beamIn to irradiated body, such as patient, the exposure cell 3 of neutron beam is irradiated, for the preparation room 4 of preparation, use before being irradiatedIn the caretaker room 5 for implementing irradiation control and under special circumstances for carrying out the auxiliary locator 6 of auxiliary positioning to patient.
Neutron beam generating unit 2 is configured to generate neutron beam outside exposure cell 3 and can irradiate neutron beam to patient.Neutron beamGenerating unit 2 includes for accelerating the cyclotron 21 of charged particle beam, reacting the neutron of generation neutron beam with charged particle beamBeam generating unit 23 and the charged particle that charged particle beam is used for transmission between cyclotron 21 and neutron beam generating unit 23Beam transport part 22.2 surrounding of neutron beam generating unit shielding wall W1 made of concrete is surrounded.Transport of Charged Particle Beams portion 22 is inBeamlet generating unit 23 transmits charged particle beam, and one end is connected to cyclotron 21, the other end is connected to neutron beam generating unit23.In other embodiments, cyclotron can be replaced using other accelerators.It can be according to actual needs in charged particleThe beam control apparatus such as beam adjustment section, current monitor, charged particle scanner section are set on beam transport part 22.Beam adjustment sectionControl the direction of travel and beam diameter of charged particle beam.The current value of current monitor the real time measure charged particle beam is (i.e. electricLotus, exposure dose rate).Charged particle beam scanner section scanning charged particle beam simultaneously controls charged particle beam to neutron beam generating unit 23Irradiation position.Neutron beam generating unit 23 includes that the target T for generating neutron beam and the neutron beam to generation are reacted with charged particle beamThe beam-shaping body 24 slowed down, shielded.The neutron beam generated in neutron beam generating unit 23 includes fast neutron beam, superthermalNeutron beam, thermal beam and gamma ray.Specifically, beam-shaping body 24 includes that the neutron beam that generated from target T can slow downTo epithermal neutron energy area slow body, will deviate from the neutron of pre-determined route back to slow body to improve epithermal neutron intensity of beamReflector, for absorb thermal neutron to avoid treatment when with shallow-layer normal tissue caused multi-dose thermal neutron absorber andFor shielding neutron and the photon of leakage to reduce the radiation shield of the normal tissue dose in non-irradiated area.As a kind of preferred realityExample is applied, target T is made of lithium metal, and charged particle beam accelerates to the energy for being enough to overcome the atomic nucleus coulomb repulsion of target T, with target TOccur7Li(p,n)7Be nuclear reaction is to generate neutron beam.Wherein, mainly epithermal neutron beam and enter the tumour of patient's bodyBoron carries out nuclear reaction and plays therapeutic effect.Target T is set to the outside of shielding wall W1, traveling of the beam-shaping body 24 along neutron beamDirection is embedded in shielding wall W1.
As shown in connection with fig. 2, exposure cell 3 includes by shielding wall W2, ceiling 37, is set on shielding wall W2 for patient's disengagingEntrance 35, open and close entrance 35 shield door D1 and enclosed and set by shielding wall W2, ceiling 37, shield door D1Shielding space 30, patient be placed in shielding space 30 receive neutron beam irradiation treat.Shielding wall W2 includes closing onFirst shielding wall 31 of beam-shaping body 24 and the opposite secondary shielding wall 32 of the first shielding wall 31 are connected to the first, second shieldingBetween wall 31,32 and be oppositely arranged third, the 4th shielding wall 33,34.First shielding wall 31 is equipped with and projects for neutron beamConiform collimator 36, neutron beam project from collimator 36 and limit a neutron beam axis X.In other embodiments, quasi-Straight device 36 can be set to the other shapes such as cylindric, rectangular-shape.Third shielding wall 33 is located at the left side of collimator 36, entrance35 be to be formed along the direction vertical with neutron beam axis X through third shielding wall 33.Be additionally provided on first shielding wall 31 byAuxiliary locator 6 is fixed to the fixed part 39 on the first shielding wall 31, and fixed part 39 is centered around the setting of 36 surrounding of collimator.
As shown in connection with fig. 3, preparation room 4 is the room for the preparation needed for implementing before irradiating neutron beam N to patient SBetween, preparation includes patient being fixed on to instrument table, positions to the tumour of patient and carries out three-dimensional localization label etc..?In the embodiment of the present application, preparation room 4 is set to the left side of exposure cell 3 and is spaced apart by barrier shield W3.In other embodiments, quasi-The arbitrary orientation in exposure cell 3 can be set in standby room 4.Preparation room 4 includes and first wall disposed in parallel of the first shielding wall 3141, positioned at 41 opposite of the first wall the second wall 42 and be located at the first, second wall 41,42 both ends and by the first, second wallThird that wall 41,42 connects, third wall 43,44 and above the first, second, third, fourth wall 41,42,43,44Roof 45.First wall 41 is equipped with the identical collimator model of structure and size with the collimator 36 in exposure cell 346, collimator model 46 also may be mounted at preparation room 4 second, third, any one sidewalls of the 4th wall 41,42,44On.4th wall 44 be equipped with along the direction vertical with neutron beam axis X through the 4th wall 41 and formed for patient intoInlet and outlet 441 and opening out, the door 442 for closing inlet and outlet 441.The inlet and outlet 441 of preparation room 4 and the entrance of exposure cell 3It is equipped with channel 49 between 35 and enters exposure cell 3 from preparation room 4 for patient.First, second, third, fourth wall 41,42,43,44, roof 45 and door 442, which enclose, is set as a closed space 40, patient S be irradiated in this enclosure space 40 before preparationWork.In the present embodiment, preparation room 4 first, second, third, third wall 41,42,43,44 and roof 45 be common wallWall, space 40 are a unmasked spaces, in other embodiments, preparation room 4 first, second, third, third wall 41,42,43,44 and roof 45 be shielding wall, space 40 is a shielding space.It is additionally provided on first wall 41 by auxiliary locator 6Fixed to the positioning region 49 on the first wall 41, positioning region 49 is arranged around collimator model 46.In positioning region 49 and exposure cell 3Fixed part 39 structure and size it is identical, meanwhile, the center of the projection with collimator 36 on the first shielding wall 31 respectivelyThe central point 460 on the basis of point of the projection of point 360 and collimator model 46 on the first wall 41, is in the present embodiment circleThe heart calls collimator central point 360, collimator model center point 460 respectively in the following text, then the coordinate value of the central point of fixed part 39 and fixedThe coordinate value of the central point in position portion 49 corresponds to identical.Specifically, setting XYZ coordinate, Y-axis are parallel to neutron beam axis X, ZAxis is the direction vertical relative to ground, and X-axis is the direction orthogonal with Y-axis and Z axis.
Caretaker room 5 is the room for managing the whole process for using neutron-capture therapy system 1 to implement.For example, managementPersonnel confirm the situation of the preparation in preparation room 4, manager works control device from the indoor naked eyes of caretaker room 5 to controlBeginning and stopping of the irradiation of neutron beam processed etc..
Shown in referring to FIG. 1 and FIG. 2, in order to which the tumour to patient S positions and is accurately irradiated, exposure cell 3 and standardPositioning system is equipped in standby room 4.Specifically, exposure cell 3 second, third, the 4th shielding wall 32,33,34 and ceiling 37On be respectively equipped with the positioning device positioned to patient S.Wherein, positioning device includes being arranged on ceiling 37 and being located at standardThe first laser locator 381 of straight 36 top of device, the second laser on secondary shielding wall 32 and positioned at 36 front of collimatorLocator 382 on third shielding wall 33 and is located at the third laser locator 383 in the left side of collimator 36 and is set to the 4th screenCover on wall 34 and be located at the 4th laser locator 384 on 36 right side of collimator.First, second, third, fourth laser locator381,382,383,384 position is fixed, i.e., its laser beam used for positioning issued is unique true in three-dimensional spaceFixed.
Referring to Fig.1 and shown in Fig. 3, preparation room 4 second, third, set on the 4th wall 41,42,44 and roof 45 respectivelyThere is the locating module that telltale mark is carried out to patient's S tumour.Wherein, locating module includes being arranged on roof 45 and being located at collimationFirst locator 481 of 46 top of device model, the second positioning on the second wall 42 and positioned at 46 front of collimator modelDevice 482 on third wall 43 and is located at the third locator 483 in the left side of collimator model 46 and is set on the 4th wall 42And it is located at the 4th locator 484 on 46 right side of collimator model.First, second, third, fourth locator 481,482,483,484 position be it is fixed, i.e., its issue laser beam used for positioning uniquely determine in three-dimensional space.
Positional relationship between first, second, third, fourth locator 481,482,483,484 and collimator model 46Positional relationship is one by one between the first, second, third, fourth laser locator 381,382,383,384 and collimator 36 respectivelyCorrespondence is identical, specifically, the point on the basis of collimator central point 360, collimator model center point 460 respectively, then and first, theTwo, third, the 4th laser locator 381,382,383,384 coordinate value respectively with the first, second, third, fourth locator481,482,483,484 coordinate value corresponds identical.
Patient S positions tumour and is done in the body surface of patient in preparation room 4 using CT images combination locating moduleThen good three dimensional indicia enters exposure cell 3 by channel 49, into after exposure cell 3, by positioning device in exposure cell 3 withThe three dimensional indicia of patient body-surface well in advance is positioned, so that neutron beam alignment tumor locus is irradiated.Specific labelMethod and localization method are technology known to those of ordinary skill in the industry, are not described in detail herein.
As shown in Figure 4, Figure 5, the auxiliary locator 6 of the application first embodiment includes the fixed part for being installed to exposure cell 339 or preparation room 4 positioning region 49 pedestal 61, with the vertically disposed cantilever 62 of pedestal 61 and be fixedly mounted on cantilever 62 4A laser emitter 63.Pedestal 61 and cantilever 62 are rectangular shape, and the middle position of cantilever 62 from pedestal 61 extends vertically,Laser emitter 63 is mounted in the plane towards collimator 36 or collimator model 46 of cantilever 62.From X-direction,In Y direction, the size of cantilever 62 is greater than collimator 36, the size of collimator model 46, and laser emitter 63 is respectively positioned on collimationExcept device 36, collimator model 46.Pedestal 61 is equipped at least two and runs through pedestal 61 from Y direction pedestal 61 to be fixed toLocation hole 610 on first shielding wall 31, the first wall 41.Pedestal 61 and cantilever 62 are by not easily-activated metal or plastics systemAt the two is made in a manner of integrally formed.Position etc. of the laser emitter 63 from close end of the cantilever 62 far from pedestal 61Spacing is arranged successively along Y-axis.Because laser emitter 63 is provided with multiple, is having barrier to block wherein one or moreWhen laser beam, the laser beam that can neatly select other not to be blocked is positioned, thus realize accurate positioning and preciselyIrradiation.
In other embodiments, pedestal 61 fits together after can be seperated molding with cantilever 62;The two is unlimitedIn the shape of cuboid, it can be the other shapes such as hexagonal prisms;The quantity of laser emitter 63 is greater than 1 any amount.
In other embodiments, can be set into can be along the form that Y-axis moves, correspondingly for laser emitter 63, cantilever 62The locating piece of selected location is fixed on equipped with the guide rail being oriented to laser emitter 63 and by laser emitter 63;Or it willCantilever 62 is arranged to the structure of extension type, by stretching, contracting cantilever 62 adjust position of the laser emitter 63 in Y-axis.At thisIn two kinds of embodiments, because position of the laser emitter 63 in Y-axis can be adjustable, only need to be arranged a laser hairEmitter 63 is that may achieve the purpose for realizing and being accurately positioned and precisely irradiating, while reducing manufacturing cost.
As shown in fig. 6, observing along the y axis, fixed part 39 corresponding with the auxiliary locator 6 of first embodiment, positioningThe shape in portion 49 is that the Jiong type structure of setting is put centered on collimator central point 360, collimator model center point 460.SpecificallyGround, fixed part 39 include the first fixed part 391 that right above collimator 36 and paralleled by X axis direction is arranged, are located at collimator36 left sides and be parallel to Z axis arrangement the second fixed part 392 and positioned at the right side of collimator 36 and be parallel to Z axis arrangement third it is solidDetermine portion 393.First, second, third fixed part 391,392,393 is embedded in the first shielding wall 31, from Y direction, theOne, second, third fixed part 391,392,393 is three end to end rectangles, and the first, second, third fixed part391,392,393 composition, one Jiong shape being arranged around collimator central point 360.First, second, third fixed part 391,392,At least two fixation holes 390 that pedestal 61 is fixed, the location hole on fixation hole 390 and pedestal 61 are respectively equipped on 393610 be threaded hole, and pedestal 61 is detachable fixed to being formed on the first, second, third fixed part 391,392,393 by screwIt is fixedly connected.In other embodiments, pedestal 61 and the first, second, third fixed part 391,392,393 can by groove withProtrusion is clasped or the modes such as magnet absorption are secured together to form detachable be fixedly connected.
As shown in fig. 7, positioning region 49 includes the first, second, third positioning region 491,492,493 and is respectively arranged at theOne, at least two location holes 490 for fixing pedestal 61 on second, third positioning region 491,492,493.Because of fixed part 39 and determineThe structure and size in position portion 49 and the central point of the two are being with collimator central point 360 and collimator model center point 460 respectivelyCoordinate value when datum mark corresponds to identical, therefore is specifically described to fixed part 39 at this, the structure of positioning region 49 and its withThe positional relationship of collimator model 46 please refers to above retouches to fixed part 39 structure and size and with the positional relationship of collimator 36It states.
One or more auxiliary locators 6 can be respectively installed to the first, second, third fixed part 391,392,393 andOne, corresponding first, third, the 4th laser locator in exposure cell 3 are replaced on second, third positioning region 491,492,493381,383,384 and preparation room 4 in first, third, one or more Laser emissions in the 4th locator 481,483,484Device is implemented to position to illuminated person.
In other embodiments, fixed part 39, positioning region 49 also may be provided at collimator 36, on collimator model 46 orOn other metopes of exposure cell 3 and preparation room 4, correspondingly the structure of auxiliary locator 6, which adjusts, can equally reach accurate fixedThe purpose of position.
As shown in figure 8, the auxiliary locator 6 ' of the application second embodiment includes being installed to fixed part 39 ' or positioning region49 ' pedestal 61 ', the laser beam emitting device 63 ' being installed on 61 ' upper cantilever 62 ' of pedestal and cantilever 62 '.Cantilever 62 ' is equipped withFor the guide rail 624 mobile in Y direction of laser beam emitting device 63 '.Laser beam emitting device 63 ' includes that can slide on guide rail 624Sliding part 631, the laser emitter 632 that is mounted on sliding part 631 and sliding part 631 is fixed on the lock on guide rail 624Determine part 634.Pedestal 61 ' is hollow cylindrical body, and it is the six of isosceles trapezoid that cantilever 62 ', which is in the direction upper section perpendicular to Y-axis,Face body, laser emitter 63 ' are mounted on the guide rail 624 towards collimator 36 or collimator model 46 of cantilever 62 '.Guide rail624 be the rectangular body for being parallel to Y-axis, and sliding part 631 straddles on guide rail 624.Locking piece 634 is selective by sliding part 631Ground is locked in some position of guide rail 624.It is additionally provided at least two on pedestal 61 ', pedestal 61 ' is fixed to the first shielding wall31, the location hole 610 ' on the first wall 41.In the Y-axis direction, the long size of cantilever 62 ' is greater than collimator 36, collimator mouldThe size of type 46, i.e. cantilever 62 ' protrude collimator 36, collimator model 46, and laser emitter 63 ' is respectively positioned on collimator 36, standardExcept straight device model 46.Pedestal 61 ' is equipped with the circular orbit (not shown) slided in a circumferential direction for cantilever 62 ' and will hangArm 62 ' is fixed on the snap close piece (not shown) of selected location, and correspondingly, cantilever 62 ' is equipped with the guiding cooperated with circular orbitPortion (not shown) and cooperate lock piece (not shown) cantilever 62 ' to be fixed with snap close piece, guide rail and guide part are normalThe form of the groove, male cooperation seen, snap close piece and lock piece are common locking device, such as elastomer and groove cooperation, spiral shellBolt and threaded hole cooperation etc..Pedestal 61 ' is made with cantilever 62 ' of not easily-activated metal or plastics.In the present embodiment, baseTwo cantilevers 62 ' are mounted on seat 61 ', and two laser beam emitting devices 63 ' are set on each cantilever 62 ', according to actual needs,1 to 3 cantilevers 62 ' can be installed, the quantity of laser beam emitting device 63 ' is more than or equal to 1 on pedestal 61 '.Because laser is sent outEmitter 63 ' can move in Y-axis along guide rail 624 ' and can navigate to arbitrarily selected position, thus there are barrier block it is sharpWhen light light beam, the position that the position of laser beam emitting device 63 ' will not be blocked to laser beam can be neatly adjusted, to realize essenceDetermine position and precisely irradiation.
In other embodiments, laser beam emitting device 63 ' can be set into multiple, from close to the separate pedestal of cantilever 62 'The position of 61 ' end is equidistantly arranged successively and is fixedly mounted along Y-axis because laser beam emitting device 63 ' be provided with it is multiple, becauseThis when there is barrier to block wherein one or more laser beams, the laser beam that can neatly select other not to be blocked intoRow positioning, to realize accurate positioning and precisely irradiation;Cantilever 62 ', which can be set into, to be fixedly mounted on pedestal 61 ';Cantilever62 ' can be set to telescopic cantilever, adjust position of the laser emitter 63 ' in Y-axis by telescopic cantilever 62 ', becausePosition of the laser beam emitting device 63 ' in Y-axis can be adjustable, therefore only needs to be arranged a laser beam emitting device 63 'Reach the purpose for realizing and being accurately positioned and precisely irradiating, while reducing manufacturing cost.
As shown in Figure 9, Figure 10, from Y direction, fixed part corresponding with the auxiliary locator 6 ' of second embodiment39 ', the shape of positioning region 49 ' is respectively two for center of circle setting with collimator central point 360, collimator model center point 460A identical annulus of size is enclosed in collimator 36, around collimator model 46 and is embedded in the first shielding wall 31In the first wall 41.At least two fixations that pedestal 61 ' is fixed are respectively equipped on fixed part 39 ', positioning region 49 'Hole 390 ', 490 ', fixation hole 390 ', 490 ' and location hole 610 ' are threaded hole, and pedestal 61 ' is fixed to fixed part by screw39 ', detachable be fixedly connected is formed on positioning region 49 '.In other embodiments, pedestal 61 ' and fixed part 39 ', positioningPortion 49 ' can be clasped by groove with protrusion or the modes such as magnet absorption are secured together, and form detachable fixation evenIt connects.
One or more cantilevers 62 ' on auxiliary locator 6 ' can navigate to corresponding position instead of corresponding in exposure cell 3The first, in third, the 4th laser locator 381,383,384 and preparation room 4 first, third, the 4th locator 481,483,484 wherein one or more laser emitters are implemented to position to illuminated person.
In other embodiments, fixed part 39 ', positioning region 49 ' can be set on collimator 36, collimator model 46Or on other metopes of exposure cell 3 and preparation room 4, the same energy of the adjustment that the structure of auxiliary locator 6 ' is correspondingly done into adaptabilityReach pinpoint purpose.
Auxiliary locator 6,6 ' can be used to replace in exposure cell 3 first, third, the 4th laser locator 381,383,384 and preparation room 4 in first, third, any one or more of the 4th locator 481,483,484 laser locator pairPatient implements positioning, need the quantity of superseded laser locator according to the actual situation depending on.In practical applications, preparingIn room 4 and exposure cell 3, when the light beam that some or the multiple laser locators that are fixedly installed in wall and ceiling issue is hiddenGear and when can not implement positioning, by auxiliary locator 6,6 ' be installed on corresponding fixed part 39,39 ', positioning region 49,49 replaces shouldOne or more laser locators implement positioning.Wherein, same group of auxiliary positioning can be used in preparation room 4 and exposure cell 3Device 6,6 ', i.e., after preparation room 4 is completed to the tumor-localizing of patient S, label, by the one or more auxiliary locator 6,6 'It removes to be installed in exposure cell 3 and continue to use;It is fixed that required amount of auxiliary can also be respectively mounted in preparation room 4 and exposure cell 3Position device 6,6 ', then reuse without dismantling in the auxiliary locator 6,6 ' in preparation room 4 to exposure cell 3.
The neutron capture treatment system that the application discloses is not limited to content described in above embodiments and attached drawing instituteThe structure of expression.Apparently change that material and shape and position on the basis of the application to wherein component are made is replacedGeneration or modification, all this application claims within the scope of.

Claims (10)

1. a kind of neutron capture treatment system, it is characterised in that: the neutron capture treatment system includes neutron generating unit, irradiationRoom, preparation room and be set to the exposure cell and it is described prepare indoor auxiliary locator, exposure cell is for irradiated bodyThe room of neutron beam is irradiated, the exposure cell is equipped with the first shielding wall, and the first shielding wall is equipped with the collimation projected for neutron beamDevice, neutron beam is projected from collimator limits a neutron beam axis, and preparation room is for implementing to irradiate neutron to illuminated personThe room of preparation needed for before beam, the auxiliary locator are equipped with transmitting laser beam to position illuminated personLaser emitter, the position of the laser emitter are selectable.
9. neutron capture treatment system according to claim 6, it is characterised in that: the pedestal and cantilever are rectangularShape, be respectively equipped on first shielding wall and the first wall around collimator, the setting of collimator model and will auxiliary it is fixedFixed part that position device is fixed, positioning region, set XYZ coordinate, Y-axis is parallel to neutron beam axis, and Z axis is relative to groundVertical direction, X-axis are the direction orthogonal with Y-axis and Z axis, and fixed part includes being located at collimator surface and paralleled by X axis directionFirst fixed part of arrangement on the left of the collimator and is parallel to the second fixed part of axis arrangement and is located on the right side of collimator and flatThe third fixed part that row is arranged in Z axis;Positioning region include first, second be correspondingly arranged with the first, second, third fixed part,Third positioning region, the first, second, third fixed part are corresponding identical as the structure and size of the first, second, third positioning region;RespectivelyCentral point with collimator in the projection on the first wall of central point and collimator model of the projection on the first shielding wall isDatum mark, the then coordinate value pair of the central point of the first, second, third fixed part and the central point of the first, second, third positioning regionIt answers identical.
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JP2020530385AJP6947934B2 (en)2017-12-182018-08-17 Neutron capture therapy system
EP18890061.7AEP3708225B1 (en)2017-12-182018-08-17Neutron capture therapy system
PCT/CN2018/100987WO2019119835A1 (en)2017-12-182018-08-17Neutron capture therapy system
US16/880,125US11583701B2 (en)2017-12-182020-05-21Neutron capture therapy system
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