A kind of hydrophilic coating solution of medical catheter and preparation method thereof and application methodTechnical field
The present invention relates to medical instruments fields, and in particular to a kind of hydrophilic coating solution of medical catheter and its preparation sideMethod and application method.
Background technique
The medical catheter used on clinical medicine at present includes catheter, stomach tube, anal canal, trachea cannula, sputum aspirator tube, noseCannula cavity etc. is internal intubation.The material of medical catheter mainly has polyurethane, silicon rubber, latex, PVC etc., these material sheetsBody does not have lubricating function, generates biggish frictional force with the cavity of human body during being inserted into human body, and not only operation difficulty is big,It returns patient and brings pain, serious damage cavity wall causes inflammation.
Ideal medical catheter material should have good hydrophily, lubricity and wearability.However, domestic currentMedical catheter material is mostly hydrophobic material, and patient suffering is operated and reduced in order to facilitate doctor, can be to the table of medical catheterIt is modified that face carries out surface.The modified hydrophily, lubricity and wearability that medical catheter can be improved in surface.Also have in the prior artApplying coating solution is carried out to the surface of medical catheter, but obtain coating firmness and stability it is poor, medical catheter tableThe coating in face is easy to fall off, and influences the lubricity and wearability of medical catheter.
Summary of the invention
For overcome the deficiencies in the prior art, one of the objects of the present invention is to provide a kind of hydrophilic paintings of medical catheterLayer solution, can assign the excellent hydrophily of medical catheter, lubricity and wearability；Its painting formed on medical catheter surfaceThe firmness and stability of layer significantly improve.
The second object of the present invention is to provide the preparation method of the hydrophilic coating solution of one of the object of the invention, the preparationThe advantages of method has simple process, easy to operate, is conducive to industrialization production.
The third object of the present invention is to provide the application method of the hydrophilic coating solution of one of the object of the invention, this methodIt is obviously improved the firmness that the coating of hydrophilic coating solution formation is connect with medical catheter, so that medical catheter is with excellentHydrophily, lubricity and wearability.
An object of the present invention adopts the following technical scheme that realization:
A kind of hydrophilic coating solution of medical catheter, which is characterized in that the component including following parts by weight:
It is 1-5 parts of hydrophilic compounds, 0.1-1.5 parts of acrylic ester compound, 0.05-0.2 parts of surfactant, light-initiated0.02-0.15 parts of agent, 65-90 parts of organic solvent, 5-30 parts of deionized water.
Further, the hydrophilic compounds be monomer or polymer with hydrophilic radical, the hydrophilic compoundsAverage molecular weight is 10000-1500000；The acrylic ester compound is list of the both ends at least containing a C=C double bondBody and/or oligomer；The surfactant is the polymer with wetting, levelling and antifoam performance.
Further, the hydrophilic compounds are selected from polyvinylpyrrolidone, n-vinyl pyrrolidone, poly- second twoOne of alcohol, polyethylene glycol oxide, polyacrylic acid, polyacrylamide, POLYPROPYLENE GLYCOL and polyacrylic acid acrylamide copolymer orIt is a variety of.
Further, the acrylic ester compound is the monomer and/or oligomer of acrylate.
Further, the acrylic ester compound be selected from ethylene glycol diacrylate, diacrylic acid pentyl diol ester,Diethyleneglycol diacrylate, polyethyleneglycol diacrylate, diacrylate 1,6-HD ester, 1,5- pentanediol diacrylateEster and polyethylene glycol dimethacrylate, propoxylated glycerine triacrylate, dipropylene glycol diacrylate, two propyleneSour tripropylene glycol ester, ethylene glycol dimethacrylate, trihydroxy methyl propane trimethyl acrylate, trimethylolpropane tris thirdOne of olefin(e) acid ester, pentaerythritol triacrylate and six acrylic acid dipentaerythritol esters are a variety of.
Further, surfactant is selected from end group Siloxane-Oxyalkylene Copolymers, silicone modified polymers or fluorine carbonizationClose one of object, dimethyl silicone polymer or polyether-modified silicon, fluorine richness alkyd copolymers and acrylic copolymer or a variety of.
Further, the photoinitiator is 2- hydroxy-2-methyl -1- phenyl -1- acetone, 1- hydroxycyclohexylphenyl firstKetone, 2- methyl-1-(4- methyl mercapto phenyl)-2- morpholine-1- acetone, 2- benzyl-2- dimethylamino-1- (4- morpholinyl phenyl) fourthOne of ketone and bis- (2,4,6- trimethylbenzoyl) phosphine oxides of phenyl are a variety of.
Further, the organic solvent is ethyl acetate, acetone, dehydrated alcohol, isopropanol, N, N- dimethyl formylAmine, DMAC N,N' dimethyl acetamide, N-Methyl pyrrolidone, N, N- dimethyl sulfoxide, butyl acetate, methylene chloride, chloroform,One of butanone and tetrahydrofuran are a variety of.
The second object of the present invention adopts the following technical scheme that realization:
The preparation method of the hydrophilic coating solution of medical catheter described in one of the object of the invention, which is characterized in that packetInclude following steps:
Organic solvent, deionized water and hydrophilic compounds are added in a reservoir, are stirred at room temperature completely molten to hydrophilic compoundsSolution；Acrylic ester compound and surfactant are added, 30-60min is stirred；Then photoinitiator is added, stirs to moltenLiquid in clear state to get.
The third object of the present invention adopts the following technical scheme that realization:
The application method of the hydrophilic coating solution of medical catheter described in one of the object of the invention, which is characterized in that packetInclude following steps:
The step of applying coating: hydrophilic coating solution is coated in medical catheter in a manner of dip-coating, spraying or brushingSurface；
The step of ultraviolet light solidifies: it is 5- that the medical catheter of the step of by the applying coating, which is placed in radiant illumination,Under the ultraviolet light of 100mW/cm2, solidifies 100-300s, obtain the medical catheter that surface cure has hydrophilic coating solution.
Compared with prior art, the beneficial effects of the present invention are:
1. the present invention improves catheter surface situation by the way that surfactant is added in hydrophilic coating solution, thus medicalCatheter surface forms uniform adhering coating, is keyed shape cross-linked structure using chemistry, and hydrophilic compounds are embedded into crosslinking knotIn the network of structure.Since the coating that hydrophilic coating solution is formed by curing is connect with medical catheter by cross-linked structure, so that the twoThe firmness of connection significantly increases, and efficiently solves the problems, such as coating in medical catheter surface firmness deficiency；Simultaneously as applyingHydrophilic compounds in layer are embedded in the grid of cross-linked structure, so that the hydrophilic compounds that cannot be reacted with medical catheterIt can be securely adhered to the surface of medical catheter, so that medical catheter has excellent hydrophily, lubricity and resistance toFrictional behaviour.
2. hydrophilic coating solution of the invention is coated on the surface of medical catheter, frictional force suffered by medical catheter can be made to dropLow 90% or more.The coating that hydrophilic coating solution is formed after rubbing action repeatedly still retains completely, suffered by medical catheterFrictional force increasing degree is no more than 3g.
3. hydrophilic coating solution of the invention is the miscible system of aqueous solvent, effectively organic solvent can be avoided to medical catheterCorrosion, it is more environmentally friendly, and can be effectively reduced the sense of discomfort of human body.
4. hydrophilic coating solution of the invention is solidified using ultraviolet light during use, ultraviolet light is each when solidifyingComponent formed cross-linked structure, while with medical catheter surface firm attachment, make medical catheter surface coating have excellent parentWater lubrication and wearability.Simultaneously as the ultraviolet light cured time is short, medical catheter will not be caused to damage, therefore, be applicable inRange is wider.Hydrophilic coating solution of the invention can provide firm hydrophilic and greasy property, the doctor that can be used for for medical catheterInstrument is treated to include foley's tube, guiding catheter, thrombus suction catheter, peripheral central venous catheter, angiography catheter, expansion pipe and tearOpen sheath etc..
5. hydrophilic coating solution of the invention only carries out primary coating, phase to the surface of medical catheter during useIt needs first to coat bottom on medical catheter surface, is coated with the double-deck coating processes on surface layer in the art for existing, it is simplerSingle, use is more convenient.
Specific embodiment
In the following, being described further in conjunction with specific embodiment to the present invention, it should be noted that is do not collidedUnder the premise of, new embodiment can be formed between various embodiments described below or between each technical characteristic in any combination.It is adoptedEquipment and raw material etc. are commercially available or commonly used in the art.Method in following embodiments, such as nothing are especially saidIt is bright, it is the conventional method of this field.
A kind of hydrophilic coating solution of medical catheter, the component including following parts by weight:
It is 1-5 parts of hydrophilic compounds, 0.1-1.5 parts of acrylic ester compound, 0.05-0.2 parts of surfactant, light-initiated0.02-0.15 parts of agent, 65-90 parts of organic solvent, 5-30 parts of deionized water.
As further embodiment, hydrophilic compounds are monomer or polymer with hydrophilic radical, hydrophilic chemical combinationThe average molecular weight of object is 10000-1500000；Acrylic ester compound is list of the both ends at least containing a C=C double bondBody and/or oligomer；Surfactant is the polymer with wetting, levelling and antifoam performance.
As further embodiment, hydrophilic compounds be selected from polyvinylpyrrolidone, n-vinyl pyrrolidone,In polyethylene glycol, polyethylene glycol oxide, polyacrylic acid, polyacrylamide, POLYPROPYLENE GLYCOL and polyacrylic acid acrylamide copolymerIt is one or more.
As further embodiment, acrylic ester compound is the monomer and/or oligomer of acrylate.
As further embodiment, it is new that acrylic ester compound is selected from ethylene glycol diacrylate, diacrylatePentadiol ester, diethyleneglycol diacrylate, polyethyleneglycol diacrylate, diacrylate 1,6-HD ester, 1,5- penta 2Alcohol diacrylate and polyethylene glycol dimethacrylate, propoxylated glycerine triacrylate, diacrylate dipropyl twoAlcohol ester, diacrylate tripropylene glycol ester, ethylene glycol dimethacrylate, trihydroxy methyl propane trimethyl acrylate, three hydroxylsOne of propane tri, pentaerythritol triacrylate and six acrylic acid dipentaerythritol esters are a variety of.
As further embodiment, surfactant is selected from end group Siloxane-Oxyalkylene Copolymers, organic-silicon-modified poly-It closes in object or fluorocarbons, dimethyl silicone polymer or polyether-modified silicon, fluorine richness alkyd copolymers and acrylic copolymerIt is one or more.
As further embodiment, photoinitiator is 2- hydroxy-2-methyl -1- phenyl -1- acetone, 1- hydroxy cyclohexylphenylBase phenyl ketone, 2- methyl-1-(4- methyl mercapto phenyl)-2- morpholine-1- acetone, 2- benzyl-2- dimethylamino-1- (4-Quinoline phenyl) one of butanone and bis- (2,4,6- trimethylbenzoyl) phosphine oxides of phenyl or a variety of.
As further embodiment, organic solvent is ethyl acetate, acetone, dehydrated alcohol, isopropanol, N, N- diformazanBase formamide, DMAC N,N' dimethyl acetamide, N-Methyl pyrrolidone, N, N- dimethyl sulfoxide, butyl acetate, methylene chloride, threeOne of chloromethanes, butanone and tetrahydrofuran are a variety of.
The preparation method of the hydrophilic coating solution of above-mentioned medical catheter, comprising the following steps:
Organic solvent, deionized water and hydrophilic compounds are added in a reservoir, are stirred at room temperature completely molten to hydrophilic compoundsSolution；Acrylic ester compound and surfactant are added, 30-60min is stirred；Then photoinitiator is added, stirs to moltenLiquid in clear state to get.
The application method of the hydrophilic coating solution of above-mentioned medical catheter, comprising the following steps:
The step of applying coating: hydrophilic coating solution is coated in medical catheter in a manner of dip-coating, spraying or brushingSurface；
The step of ultraviolet light solidifies: it is 5-100mW/ that the medical catheter of the step of by applying coating, which is placed in radiant illumination,Under the ultraviolet light of cm2, solidifies 100-300s, obtain the medical catheter that surface cure has hydrophilic coating solution.
Embodiment 1:
A kind of hydrophilic coating solution of medical catheter, taking molecular weight is the polyvinylpyrrolidone of 500,000 dalton2g, dehydrated alcohol 85g, deionized water 12.4g is placed in container, stirs at room temperature, until polyvinylpyrrolidone is completely dissolved.Ethylene glycol diacrylate and polyethyleneglycol diacrylate mixture 0.5g, end group Siloxane-Oxyalkylene Copolymers 0.05g are added,Continue stir 30min, then be added 1- hydroxycyclohexyl phenyl ketone 0.05g, stirring to transparent clear state to get.
The application method of the hydrophilic coating solution of above-mentioned medical catheter, comprising the following steps:
The step of applying coating: hydrophilic coating solution is coated in the surface of medical catheter in a manner of dip-coating；
The step of ultraviolet light solidifies: it is 100mW/ that the medical catheter of the step of by applying coating, which is placed in radiant illumination,Under the ultraviolet light of cm2, solidifies 200s, obtain the medical catheter that surface cure has hydrophilic coating solution.
Embodiment 2:
A kind of hydrophilic coating solution of medical catheter, taking molecular weight is the polyvinylpyrrolidone of 500,000 dalton3g, isopropanol 80g, deionized water 15.92g is placed in container, stirs at room temperature, until polyvinylpyrrolidone is completely dissolved.Add the mixture of propoxylated glycerine triacrylate, ethylene glycol diacrylate and polyethyleneglycol diacrylate0.9g, dimethyl silicone polymer 0.1g continue to stir 60min, 1- hydroxycyclohexyl phenyl ketone and 2- methyl-1-are then addedThe mixture 0.08g of (4- methyl mercapto phenyl) -2- morpholine -1- acetone, stirring to transparent clear state to get.
The application method of the hydrophilic coating solution of above-mentioned medical catheter, comprising the following steps:
The step of applying coating: hydrophilic coating solution is coated in the surface of medical catheter in a manner of brushing；
The step of ultraviolet light solidifies: it is 5mW/cm2 that the medical catheter of the step of by applying coating, which is placed in radiant illumination,Ultraviolet light under, solidify 200s, obtain the medical catheter that surface cure has hydrophilic coating solution.
Embodiment 3:
A kind of hydrophilic coating solution of medical catheter, taking molecular weight is the polyvinylpyrrolidone of 1,000,000 daltonWith the mixture 3g for the polyethylene glycol oxide that molecular weight is 300,000 dalton, dehydrated alcohol 85g, deionized water 11.02g are placed in containerIt is interior, it stirs at room temperature, until polyvinylpyrrolidone and polyethylene glycol oxide are completely dissolved.Add three propylene of propoxylated glycerineThe mixture 0.8g of acid esters and polyethyleneglycol diacrylate, fluorine richness alkyd copolymers 0.1g continue to stir 60min, thenThe mixture 0.08g of 1- hydroxycyclohexyl phenyl ketone and 2- methyl-1-(4- methyl mercapto phenyl)-2- morpholine-1- acetone is added,Stirring to transparent clear state to get.
The application method of the hydrophilic coating solution of above-mentioned medical catheter, comprising the following steps:
The step of applying coating: hydrophilic coating solution is coated in the surface of medical catheter in a manner of spraying；
The step of ultraviolet light solidifies: it is 50mW/cm2 that the medical catheter of the step of by applying coating, which is placed in radiant illumination,Ultraviolet light under, solidify 240s, obtain the medical catheter that surface cure has hydrophilic coating solution.
Verify embodiment:
By following tests come the beneficial effect of the hydrophilic coating solution for the medical catheter that the present invention is further explained, examinationIt tests and the results are shown in Table 1.
1, lubricity is tested: being taken a root long degree not less than 30cm medical catheter, is averagely cut into two sections, one section coats this hairBright hydrophilic coating solution, another section is not coated by.It is first that one end of the medical catheter of no coating hydrophilic coating solution is vertically solidBe scheduled in the upper clamp of stretching-machine, the other end protrudes into the clamping tooling for being fixed on stretching-machine lower part, tooling be provided with fromSub- water, the other end of medical catheter are clamped in rubber fixture block, and apply 300g chucking power.Under certain speed, stretched vertically is ledPipe utilizes the frictional force in stretching-machine connection mechanics sensor record conduit drawing process.It is coated with the test of same methodThe difference of the medical catheter of hydrophilic coating solution, the two friction value reflects the Hydrophilic lubrication of medical catheter.Record twoPartial frictional power numerical value, obtains frictional force decreasing value, is denoted as f-r, and f-r is bigger, illustrates that lubricity is better.
2, wearability test: the medical catheter for being coated with hydrophilic coating solution loads the equipment tested to above-mentioned lubricityOn, make sliding block up-and-down movement 50 times under fixed moving distance and speed by process control, when record start is with terminatingFriction value, the abrasion that the difference of the friction value reflects the coating on medical catheter falls off degree and medical catheterWearability.The numerical value that frictional force increases when terminating is denoted as f-i, f-i value is smaller, illustrates that wearability is better.
Table 1 is the performance test results table of embodiment 1-3 and blank control
As it can be seen from table 1 the hydrophilic coating solution of medical catheter of the invention is coated in the surface of medical catheter, it canTo effectively improve the lubricity and wearability of medical catheter.
The above embodiment is only the preferred embodiment of the present invention, and the scope of protection of the present invention is not limited thereto,The variation and replacement for any unsubstantiality that those skilled in the art is done on the basis of the present invention belong to institute of the present inventionClaimed range.