The present invention relates to it is a kind of according to claim 1,9,15 and 22 preamble analysis system, be related to according to claim32, the method for 33,34 and 35 preamble, and it is related to a kind of computer program product.
Preferably, the present invention relates to analyze and test the sample especially from mankind or animal, particularly preferably is used for(for example) about the existing analysis and diagnosis of disease and/or pathogen and/or for measuring blood count, antibody, hormone, classSterol or fellow.Therefore, the present invention especially belongs in field of bioanalysis.Also foodstuff samples, environment sample can optionally be testedProduct or another sample, especially for environmental analysis or food security and/or for detecting other substances.
Preferably, by virtue of this invention, it can measure, identify or at least one analyte (target analytes) of test sample.In particular, sample can qualitatively or quantitatively measure at least one analyte after tested, such as to can detect or identify diseaseAnd/or pathogen.
Within the meaning of the present invention, analyte especially nucleic acid sequence (especially DNA sequence dna and/or RNA sequence) and/orProtein (especially antigen and/or antibody).In particular, by virtue of this invention, nucleic acid sequence can after measured, identify or be detected as sampleThe analyte and/or protein of product can after measured, identify or be detected as the analyte of sample.Most particularly preferably, the present invention relates toAnd for carrying out foranalysis of nucleic acids for detecting or identifying nucleic acid sequence and/or for detecting or the protein of identification of protein pointSystem, device and other devices of analysis.
In particular, the present invention relates to the systems of referred to as point-of-care (point-of-care) system, that is, more particularly to rowDynamic system, device and other devices, and be related at sampling site and/or independently and/or far from central laboratory or classThe method that test is carried out to sample like person.Preferably, point-of-care system can be independently and/or independently of the master for supplying electric powerPower supply network operation.
US 5,096,669 discloses a kind of for testing the point-of-care system of biological sample (especially blood sample).SystemSystem includes disposable storage tube and analysis device.Once having received sample, just storage tube is inserted into analysis device so as to realityRow test.Storage tube includes microfluidic system and the sensor device including electrode, which is calibrated by calibration liquidAnd it is then used to test sample.
In addition, 2006/125767 A1 of WO discloses a kind of fixed point photograph for integrating and automating DNA or protein analysisProtecting system comprising disposable storage tube and for using the disposable storage tube completely automatically to handle and assessing molecular diagnosisThe analysis device of analysis.Storage tube be designed to receive sample (especially blood), and especially allow clasmatosis, PCR andThe detection of pcr amplification product, pcr amplification product are bonded to capture molecule and are provided with label enzyme, in order to be known as oxidation alsoDetection bond pcr amplification product or core sequence are as target analytes in the program of former cyclic program.
100 58 394 C1 of DE discloses a kind of method using reaction array test sample, which includes being used forAt least two reaction compartments of the substance received and reacted with each other, these reaction compartments are by the interconnection of supply space.For measurementSubstance prevents the exchange and therefore chemical crosstalk of the substance between individual reaction compartments by reduction sensor cover.With thisThe detection sensitivity of mode, this method increases.
2 305 383 B1 of EP discloses a kind of for carrying out and analyzing the instrument of Microarray Experiments.In particular, this document is taken offShow parallel implementation Microarray Experiments to detect the specificity between probe molecule and target molecule in microtiter plate mutuallyEffect.In this case, the probe in the form of substance library is provided on carrier, and therefore can be in plurality of probes concurrentlySample is analyzed simultaneously.Under the background of such Microarray Experiments, also disclosing can be in outside especially by user to processing unitSpecified wanted operation mode.
2011/0253224 A1 of US discloses the feedback control in a kind of microfluidic system.The control of fluid is related to using nextThe feedback of the one or more programs or event that occur in comfortable microfluidic system.For example, detector can be examined at measured zoneIt surveys one or more fluids and uses this data, control system can be determined whether to adjust the subsequent fluid stream in microfluidic systemIt is dynamic.
2015/0148705 A1 of US is disclosed for sampling and analyzing the system and device of the micropopulation of skin.MicroorganismAnalyzing device includes the hand-held housing with elongated flexible band, which includes microorganism-capturing region and positionInformation storage assembly.The band is configured to one or more areas captured microorganisms from personal skin surface, and position is believedBreath storage assembly is configured to storage information associated with the position in the one or more region.
2014/0296089 A1 of US is disclosed for the mostly system and method for analysis and sample treatment.Can provide can receiveSample and execute sample preparation, sample analysis and detecting step one or more device.The device can be able to carry out multiple pointsAnalysis.
20 2,010 007 208 U1 of DE discloses a kind of for testing the device for applying the body fluid for being overlying on carrier material.The devicePart includes at least two devices for determining the different material being present in body fluid, wherein the carrier material being inserted into deviceMaterial is provided with the coding for being specific to related body fluid and substance to be determined.Relevant apparatus can be started via corresponding encode.In addition, can mentionFor additional external device to assess and measurement result is presented.
2002/0060247 A1 of US discloses a kind of analyte testing instrument system and one kind comprising data management systemThe method that management is connected to the data of a plurality of analyte testing instruments at data communication network.Method includes the following steps:Via the connection of each instrument of Framework computing machine testing to data communication network；It will be from the received data upload of each instrument to host meterCalculation machine；Processing uploads data so that operator inspects on a host computer；And configuration data is downloaded to from host computerEach test equipment, downloading data include the specific setting of instrument and control data.
2,013 201509 B2 of AU discloses point-of-care fluid system and application thereof.Clearly say it, the present invention provides permissionThe portable medical device of analyte from biofluid detected immediately.For detecting the system packet of the analyte in body fluidFluid device is included, wherein the sample of body fluid can be anti-with the reactant that is housed in device based on the agreement transmitted from external devicesIt should be to generate the existing detectable signal for indicating the analyte.The system further comprises for detecting the detectable signalRead device assembly.External devices are reading the outside of device assembly and a plurality of agreements of storage, are configured to wherein reading device assemblyThe specific agreement of the fluid device of a plurality of agreements of the downloading in external devices is run on the identity based on fluid deviceOn the fluid device.
5,961,451 A of US discloses a kind of non-intruding with the fixation member to fixed removable biosensorFormula device.The device includes preferably non-invasively to extract biological sample from terminal user through skin by transdermal penetrationThe non-intrusion type extraction device of product.The device further comprises to sense the characteristic of biological sample, property or the biology of parameterSensor.
2006/0292039 A1 of US, which discloses one kind, can allow user in the case where not visiting mechanism for testing in desired positionSet the measuring system for checking his/her health status.Firstly, user collects body fluid, crystalline substance is introduced to as sampleIn piece.Make sample effect in detection reagent, the specific components acted in sample are to generate predetermined detection reaction.Chip warpSetting measures the quantitative specific components of one of sample to mobile terminal.Measured value is transmitted in analysis by this action terminalThe heart.
2015/0244852 A1 of US discloses a kind of device and method for collecting measurement on the spot for biomolecule reaction.By biological specimen collection on mcxlular diagnosis test platform, which is inserted into intelligent telephone accessory.Using optics,Electrically, mechanical or other devices carry out converting biological molecular binding event and exchange result with intelligent telephone.As a result it can then pass throughIt is quantitative to present, it is shown to user, is stored for then comparing, and is transferred to during health workers can provide and additionally inspectHeart hub location.
It is intended to provide a kind of analysis system for assessing sample, method and computer journey by problems solved by the invention systemSequence product, can more efficient, individual and/or flexible way test sample and/or test measurement result.
By according to claim 1,2,3 or 4 analysis system, by the method according to claim 32,33,34 and 35Or it solves the above problems by according to the computer program product of claim 36.Advantageous development is the master of appended claimsTopic.
Itd is proposed analysis system is provided to test especially biological sample.
Analysis system especially for portable, mobile model and/or be point-of-care system and/or be or may automatically,Especially independently of electric power network, especially at sampling site and/or far from central laboratory and/or by electric power storage listAtom operation.
Analysis system preferably includes the analysis device and storage tube for test sample, which preferably uses through designIn receiving sample.It is particularly preferred that analysis device is designed to receive storage tube or is designed to electricity, heat and/or pneumatically connectsConnect the storage tube.Analysis device is preferably designed to that received storage tube is then used to carry out test.For this purpose, storingCylinder can be inserted into or be loaded into analysis device, therefore is analyzed device and be may act on storage tube to carry out test.
The storage tube preferably provides the channel of transportable sample.This make sample can be pre-processed or be handled on card and/Or make sample that can be assessed or be analyzed by the sensor device being preferably also located on card.
It is particularly preferred that analysis system includes operation instrument.This operation instrument may be or include intelligent telephone, plate meterCalculation machine or fellow.Therefore, operation instrument is especially carrying and/or action (terminal) device.
The operation instrument preferably physically and/or relative to data connection with analysis device is separated or is separated.This can (exampleAs) by disconnect or terminate or failure analysis device and operation instrument between data connection (especially manually or byOperation instrument is removed from analysis device) and reach.
Alternatively or additionally, it is provided that operation instrument can wirelessly and/or via radio connection or air interface connectOr it is connected to analysis device.It is particularly preferred that operation instrument can or be relative to data connection (especially via referred to as dedicated numberAccording to connection or dedicated network connection, such as bluetooth connection, automatically establish and/or configure) be automatically connected to analysis device and/Or it disconnects and/or separates with analysis device.In addition to bluetooth standard, other known short range transmissions methods, NFC, WPAN orWLAN is also suitable.
By operation instrument, the configuration of analysis device needed for preferably may achieve test, and therefore analysis device need notIncluding any complicated User's Interface, but analyzes device and preferably include at most an on-off switch and basic status display(not including screen or fellow).This advantageously to can be used the standard hardware that can be configured with flexible way (such as intelligentPhone or tablet computer), to reach user close friend's configuration, to enable or promote the embodiment about operation instrumentFlexibility and so as to by it is simple and based on software in a manner of update corresponding data and interface.
In this regard, it is preferably designed to determine, read or receive to correspond to one aspect of the invention is operation instrumentIn storage tube storage tube identifier and using the storage tube identifier come from database retrieval control information with carry out test, shouldInformation be specific to storage tube or the storage tube assign in batch, and/or the information is transmitted to analysis device.
Advantage in this respect is: therefore control information that is individual, unique and/or being specific to specific storage tube can be used.This control information may be incorporated into the property feature of specific storage tube or a collection of storage tube, Deng being for example related to substance therein, aboutThe adaptability of a certain test, about the use of certain sensors configuration, or about the specific information for carrying out test, wherein believingBreath is suitable for storage tube, batch or fellow, and contains such as adjustment number, temperature or fellow.
On this aspect, can with analysis device isolation and/or disconnect and/or be wirelessly coupled to analysis device operationThe use of instrument is particularly advantageous in that storage tube or storage tube batch can add in a simple manner and independently of analysis deviceWith identification, and corresponding control information can with analysis device isolation and/or disconnect, also can temporarily (such as shifting to an earlier date) be retrievedAnd/or storage.Then, control information can be in subsequent stage, also independently of between operation instrument and Internet and/or databaseLink transmission to analyzing device.
Also the another aspect according to the present invention that can be independently implemented, operation instrument are preferably designed to that information will be controlledAnalysis device is transmitted to carry out the test supported by storage tube, which is specific to storage tube or storage tube is signifiedThe batch of group, analysis device are designed to use with separating and/or disconnect independently of operation instrument and/or with operation instrumentThe control information of transmission is tested to carry out.
Therefore, analysis system is preferably by operation instrument configuration to the survey for the especially biological sample for using storage tube to carry outThis degree that examination can be started by analysis device or be started by analysis device.Then, operation instrument need not keep permanently connectingIt is connected to analysis device, and therefore operation instrument relative to data connection and analysis device isolation and/or can be disconnected with itMode uses.
This allows to flexible way and operation instrument is disposed and used independently of analysis device, is especially grown in sampleIn the case where time test.Another advantage is that analysis device can follow corresponding configuration and automatically operate, and therefore sample is appropriateThe maintenance for testing independent of operation instrument and analyzing the radio connection between device, can suffer from interfering, and due to surveyingThe maintenance independent of radio connection is tried, therefore test can be carried out advantageously in a manner of very steady, reliable and anti-interference.
Also the another aspect according to the present invention that can be independently implemented, analysis device are designed to receive control from operation instrumentInformation processed (information is specific to storage tube or the storage tube assign in batch), be designed to using control informationThe test of the sample in storage tube is controlled, and is designed to measure during test without any previous evaluationMeasurement result is transmitted to operation instrument.
It is therefore especially preferred that ground is by operation instrument preferably in analysis device external interpretation measurement result.Alternatively, soAnd assessing can also carry out in outside, measurement result can be sent to servomechanism by operating instrument for this purpose, such as.AnalyzerPart is not arranged to preferably directly explain the measurement result of the test from sample.
Advantageously, the advantage especially by operation instrument in analysis device external interpretation measurement result is: assessment sideMethod can be adjusted dynamically without making any change to analysis device.This based in the initial state with analysis device isolationAnd it is inserted into particularly advantageous in the background content in analysis device to carry out this analysis system of the storage tube of test.
On this aspect, this system provides the flexibility that using different storage tubes different samples are carried out with different tests.Then, different measurement results can be explained then in different ways.Analysis device is set to adapt to the contingent condition system complexity of this typeAnd may require replacing hardware over time, become, because processing capacity is too low or because other a certain adjustments require, even ifThe mechanical component for analyzing device may be virtually without replacement.
Consequently, it was found that particularly advantageously, analysis device physically separates with operation instrument and by operation instrument or warpBy operation instrument in analysis device external assessment measurement result, especially because operation instrument can be simpler and more cost is imitatedBeneficial mode and the complexity that the analysis device for using storage tube to carry out test also need not be also exchanged by more frequent interval replacementMechanical system.
The another aspect that can also independently implement of the invention also relates to the assessment of measurement result.In this regard, preferablyGround operation instrument is designed to determine, read or receive the storage tube identifier for corresponding to storage tube and be identified using the storage tubeFu Laicong database retrieval is designed for the assessment information of the measurement result measured during assessment test, which is especiallyBe specific to storage tube or the storage tube assign in batch, and be designed to independently of analysis device and/or with analysis deviceDiscretely and/or with disconnecting carry out assessment of the measurement result using assessment information.
On this aspect, advantage is: by using storage tube identifier to identify storage tube, can be used for storage tube or storageObject cylinder batch is individual or uniquely assesses information.In this regard, sample preparation, storage tube, environmental condition and/or sensing can be consideredThe property of device configuration is specific to storage tube and is conducive to quick and/or reliable assessment the other information of measurement result.
It has been to illustrate further advantage, reference analysis device in the background content for analyzing device external assessment measurement resultPart.
Another advantage system can be in operation instrument with individual and corresponding exact way assessment of the measurement result.If assessment information mentionsIt is preceding from database retrieval and to be initially temporarily stored in operation instrument (such as situation in a preferred embodiment), it can although havingFlexible hardware, there is no need to be connected to Internet or other servomechanisms and/or database to carry out assessment of the measurement result.
This is preferably to determine for what live (that is, in ambient enviroment of sampling site) used in conjunction with proposed analysis systemThe fact that point care system is particularly advantageous.It such as has a question, proposed analysis system is for example in rural area in pig house or mountainOn area pasture, wherein poor infrastructure point, which may typically result in, cannot reliably obtain mobile communication connection or fellow.?In this situation, particularly advantageously, discretely and/or with disconnecting instrument is being operated in analysis device exterior and with analysis deviceMiddle assessment of the measurement result.
The present invention is also related to a kind of method by analysis system test especially biological sample, which includes storageObject cylinder, the analysis device for receiving storage tube and operation instrument, operation instrument preferably can be relative to data connections and analysisDevice isolation and/or disconnect and/or can be wirelessly coupled to relative to data connection analysis device.
According to the one aspect that can also independently implement of proposed method, determining, reading or reception by operation instrumentStorage tube identifier corresponding to storage tube.Using storage tube identifier, information is controlled from database retrieval and/or is transmitted to pointParser part.In this case, control information is preferably specific to storage tube or batch associated with its storage tube, the storingCylinder or batch correspond to the storage tube identifier.In addition, control information is designed to control analyzer part to use storage tubeCarry out test.Therefore, may achieve at the beginning it is stated that advantage.
In the another aspect that can also independently implement of proposed method, operation instrument is transmitted to analysis for information is controlledDevice, control information are preferably specific to storage tube or batch associated with the storage tube and/or are adapted for carrying out by storingThe test that cylinder is supported.In addition, analysis device discretely and/or disconnects ground independently of operation instrument and/or with operation instrumentTest is carried out using the control information of transmission.Therefore, may achieve at the beginning it is stated that advantage.
According to the another aspect that can also independently implement of proposed method, device is analyzed from operation instrument and receives control letterBreath, the information are preferably specific to storage tube and/or batch.Analysis device controls the sample in storage tube using control informationTest.The measurement result measured during test is transmitted to operation instrument without any previous evaluation.Therefore, may be usedReach at the beginning it is stated that advantage.
According to the another aspect that can also independently implement of proposed method, operates determining instrument, reading or receive correspondenceIn storage tube or the storage tube identifier of batch.Using storage tube identifier, storage tube is preferably specific to from database retrievalOr the assessment information of batch, the assessment information are suitble to or are designed for the measurement result that assessment is measured dduring test.MakeWith assessment information, independently of analysis device and/or with analysis device discretely and/or disconnect ground assessment of the measurement result.CauseThis, may achieve at the beginning it is stated that advantage.
Therefore, it initially can provide operation instrument and analyze the data connection between device.Then, control information preferably passesTransport to analysis device.In this case, control information preferably corresponds to or be the storage tube loaded into analysis device, orCorresponding to batch associated with the storage tube.Using control information, the sample that test is received in storage tube is preferably started.Test started after, operation instrument can with analysis device isolation and/or disconnect or operate instrument and analysis device divideFrom and/or disconnect, and the test rely on including storage tube and independently of operation instrument analysis device continue, preferably directlyTo terminating.Then, operation instrument can be transmitted to by testing resulting measurement result.If operate instrument previously with analysis device isolationAnd/or disconnect, then once operation instrument has reconnected to analysis device and/or re-established operation instrument and analysisData connection between device, just preferably automatic transmission measurement result.
Also the another aspect according to the present invention that can be independently implemented, analysis device are specific to storing from operation instrument receptionThe control information of cylinder.Analysis device controls the test of the sample in storage tube using control information.Without any previous evaluationIn the case where the measurement result measured during test is transmitted to operation instrument.
Also the another aspect according to the present invention that can be independently implemented, operation instrument is determining, reads or receives corresponding to storageThe identifier of object cylinder.Using identifier, the assessment information of storage tube is specific to from database retrieval, which is suitble to or warpDesigned for assessing the measurement result measured dduring test.Using assessment information, independently of analysis device and/or with analysisDevice isolation and/or disconnect ground assessment of the measurement result.
The another aspect that can also independently implement of the invention is related to a kind of computer program including program code devicesProduct, program code devices for example by processor, computer, microcontroller or for execute especially operate instrument and/Or when other data processing equipments execution of the one or more of the program code devices of analysis device, cause to carry out according to the present inventionMethod and step or method.
Term " analysis device ", which is preferably understood that, means instrument, can use specifically for mobile model and/or at the scene,And/or it is designed to preferably in storage tube and/or by storage tube chemistry, biology and/or physical testing and/or analysisSample or its component.In particular, the pretreatment and/or test of the sample in analysis device control storage tube.For this purpose, divideParser part may act on storage tube, in particular so that sample is conveyed in storage tube, temperature controls and/or measurement.
Term " storage tube ", which is preferably understood that, means constructional device or unit, be designed to receiving, storage, physics,Chemistry and/or biological treatment and/or preparation and/or measurement sample, preferably for detectable, identification or measure sample at leastOne analyte, especially protein and/or nucleic acid sequence.
Storage tube in meaning of the invention preferably includes with plurality of channels, cavity and/or for controlling by logicalThe fluid system of the valve of the flow of road and/or cavity.
In particular, within the meaning of the present invention, storage tube is designed at least general planar, flat and/or card-like, especiallyIt is to be designed to (micro-) fluid card and/or be designed to the main body being preferably closed or container and/or the storage tube can be at itInsertion and/or plug extremely propose in analysis device when accommodating sample.
Term " operation instrument ", which is preferably understood that, means device, by the controllable analysis device of the device, can will controlInformation is transmitted to analysis device, and/or measurement result can be received from analysis device and/or can assessment of the measurement result.Preferably, it graspsMake instrument system or forms the User's Interface of assessment or the output for controlling test and/or measurement result.
Operation instrument is alternatively referred to as operator and controls instrument.Operation instrument is preferably configured by operator(user) operation especially analyzes device, test and/or assessment to control.Therefore, instrument system is operated or including for inputtingOrder and the User's Interface that control block of information is sent to analysis device.
Operation instrument is preferably included for control analyzer part, for controlling data transmission and/or for controlling measurement knotThe input unit of the assessment of fruit.Alternatively or additionally, operation instrument includes that information is (especially for exporting and (especially showing)Status information), the output device of operating element and/or result.Operation instrument preferably includes to be used for data transmission for executingComputer program product, for control and/or for assessment of the measurement result processor, microcontroller and/or memory.
It is particularly preferred that operation instrument system is especially the mobile terminal device for being used for radio and/or network of taking action, such asIntelligent telephone, tablet computer, mobile phone or fellow.Operation instrument preferably independently of electric power network, use electricityPower storage device (especially (rechargeable) battery) and with action modes, automatically and/or independently of analysis system into oneComponent (especially analysis device) is walked to operate.Operation instrument preferably includes to connect for the one or more of wireless data communicationMouth, especially WPAN communication interface, WLAN communication interface, near field communication interface, optical communication interface (such as camera), and/orMobile radio interface.
Term " test " as used in this article preferably means test program/sequence and/or executes analysis, especially usesIt analyzes in executing to measure one, several or Overall Steps of one or more analytes of sample.These steps preferably byIt is realized by analysis system, analysis device and/or storage tube or in its etc..
Mesh of " analysis " the according to the present invention preferred system for qualitatively and/or quantitatively measurement, detection and/or identification sampleMark the search procedure of the presence of entity or analyte, quantity and/or functional activity.Analyte can (for example) be drug, biology, changeCell in and/or biochemical and/or organism or organic sample.In particular, analyte can be molecule, nucleic acid sequenceColumn, DNA, RNA and/or protein.
Preferably, analysis system according to the present invention is for detecting or identifying the foranalysis of nucleic acids of nucleic acid sequence and/or for examiningThe protein analysis of survey or identification of protein.
Analysis, test or test program according to the present invention are correspondingly preferably covered at least one of following: controlAnalyze the actuator of device, such as pump controller, temperature control equipment and valve actuator；Act on storage tube or sample；ProcessingSample；Prepare sample；It executes and one or more combination process of sample and/or reacts；Convey sample；And especially use storingThe sensor device of cylinder measures one or more properties of sample.
Sensor device or its sensor array are preferably included for specificity bond and/or are detected to be detected or measurementThe multiple sensors fields and/or electrode of one or more analytes.In addition, sensor device is preferably configured for sampleThe electricity or Electrochemical Detection of analyte.
Alternatively or additionally, sensor device and/or sensor component can be configured in the feelings without specificity bondTomography under condition and/or by optical measurement, impedance measurement, capacitance measurement, spectral measurement, mass-spectrometer measurement or such as MRTIt detects or measures other or further analyze compounds, material property or fellow.On this aspect, sensor device therefore canIt is formed by the configuration for enabling this measurement.In particular, any other of sensor device or storage tube or analysis device or systemSample carrier may include or formation has the cavity of the window for the optical measurement.Optical sensor or sensor device are (such asSpectrometer) can independently of storage tube realize and/or can be formed analysis device part.
Hereinafter, be based primarily upon with multiple sensors fields and/or be or include with for Electrochemical Detection electricityThe sensor device of the chip of pole illustrates the present invention.However, unless understand regulation or bootable on the contrary, otherwise it will be appreciated thatMeasurement result can alternatively or additionally be reached by the one or more of above-mentioned measuring technique or can be one of above-mentioned measuring techniqueOr more persons' as a result, even if being not expressly mentioned.
Analysis, test or test program according to the present invention preferably act on storage tube and/or sample to analyze deviceAnd/or the program on control storage tube and/or sample starts or starts.It is risen in particular, test acts on storage tube with actuatorDynamic or beginning.It is started for example, test can convey the sample in storage tube.
Before storage tube is inserted into analysis device or receives storage tube by analysis device and/or in conveying, processingAnd/or prepare method and/or step analysis preferably not according to the present invention, survey that the sample in the storage tube executes beforeThe part of examination or test program.
Therefore, " control information " is preferably configured to carry out this analysis, test or test program or be configured so as to divideAnalysis system or analysis device can carry out this analysis, test or test program.Preferably, the control information be configured to control orIt defines control sequence or is used by analysis device to carry out the analysis, test or test program.Therefore, " information is controlled " preferablyBe configured to control analysis, test or test program instruction.In particular, control information be configured to include by definitionThe step of control and/or feedback control actuator (such as pump controller, temperature control equipment and valve actuator) or step parameterAnd control analysis, test or test program.
Aforementioned aspect of the present invention and feature and from invention claims and clear side of the invention will be described belowFace and feature can be implemented independently of one another in principle, but also be implemented with any combination or sequence.
Reference attached drawing is understood into its other party of the invention from invention claims and being described below for preferred embodimentFace, advantage, feature and property, in which:
Fig. 1 by include be received in proposition storage tube therein proposition analysis system and/or analyze the signal of deviceFigure；
Fig. 2 is the schematic diagram of storage tube；
Fig. 3 is the schematic diagram of analysis system；And
Fig. 4 shows the schematic sequence for using analysis system.
Only be schematically and sometimes in the figure that is not drawn on scale, similar elements symbol for same or like part andComponent still reaches corresponding or comparable property and advantage even if these non-repeated descriptions.
Specific embodiment
Fig. 1 is especially biological for preferably relying on device or storage tube 100 or testing in device or storage tube 100The itd is proposed analysis system 1 of sample P and the high-level schematic for analyzing device 200.
Fig. 2 by for test sample P one of proposition device or storage tube 100 preferred embodiment schematic diagram.DeviceOr storage tube 100 especially forms handheld unit, and hereinafter only referred to as storage tube.
Term " sample ", which is preferably understood that, means specimen material to be tested, especially obtains from mankind or animal.It is specialIt is not that within the meaning of the present invention, sample system is preferably from the fluid of mankind or animal, such as saliva, blood, urine or anotherOne liquid or its component.Within the meaning of the present invention, sample when necessary can be preprocessed or be prepared, or may be directly from peopleClass or animal or fellow, such as.Foodstuff samples, environmental sample or another sample also can be tested optionally, and environment is especially used forAnalysis, food security and/or for detecting other substances, preferably natural materials, but also biological or chemical war agent, poisonous substance or classLike person.
Preferably, analysis system 1 and/or the control of analysis device 200 especially in the storage tube 100 or on sample PIt tests and/or carrys out the measurement result of self-test for assessing test and/or collection, processing and/or storage.
Analysis system 1 preferably includes one or more storage tubes 100 for receiving sample P.Analysis system 1 preferably includesFor receiving storage tube 100 and then carrying out the analysis device 200 tested using received storage tube 100.
By proposed analysis system 1, analysis device 200 and/or storage tube 100 and/or using for test sample P'sProposed method, the preferably analyte A (especially (specific) nucleic acid sequence and/or (specific) protein) of sample P or specialPreferably a plurality of analyte A of sample P can after measured, identification or detection.These analytes A is especially not only qualitatively, andAnd it particularly preferably quantitatively detected, identified and/or is measured.
Therefore, sample P, which can be especially, is used to qualitatively or quantitatively measure after tested at least one analyte A, such as so as toDetectable disease and/or pathogen can measure important other values for diagnosis, such as.
It is particularly preferred that molecular biology test is by analysis system 1 and/or analysis device 200 and/or relies on storage tube100 and become feasible.
It is particularly preferred that for detect nucleic acid sequence (especially DNA sequence dna and/or RNA sequence) foranalysis of nucleic acids and/orProtein analysis for detecting protein (especially antigen and/or antibody) is possibly realized or is implemented.
Preferably, the individual components or analyte A of sample P or sample P can be especially when necessary relies on PCR amplification, andIt tests, identify or detects in analysis system 1, analysis device 200 and/or in storage tube 100, and/or for carrying out nucleic acid pointThe purpose of analysis.Preferably, thus generate one or several analyte A amplified production.
Hereinafter, the preferable configuration primarily with respect to storage tube 100 provides further details, wherein the spy of storage tube 100Sign preferably also directly indicates the feature of analysis system 1, especially even further clarifies explanation without any.
Storage tube 100 is preferably at least general planar, flat, plate shape and/or card-like.
Storage tube 100 preferably includes especially at least general planar, flat, plate shape and/or card-like main body or supporting element101, the main body or supporting element 101 are especially made of plastic material (particularly preferably polypropylene) and/or (special from plastic materialNot preferably polypropylene) ejection formation.
Storage tube 100 is preferably included at least partly covering main body 101 and/or formed therein (especially in front end)Cavity and/or channel and/or be used to form valve or at least one film or the cover 102 of fellow, such as by the dotted line in Fig. 2It shows.
Analysis system 1 or storage tube 100 or its main body 101 are especially preferably formed as and/or including fluid together with the cover 102System 103 is hereinafter referred to as fluid system 103.
Storage tube 100, main body 101 and/or fluid system 103 in operating position and/or dduring test, particularlyIt is preferably at least oriented substantially vertically in analysis device 200, schematically shows as shown in figure 1.In particular, the master of storage tube 100Therefore plane or surface extend at least to be extended substantially vertically in operating position.
Storage tube 100 and/or fluid system 103 preferably include a plurality of cavitys, in particular at least one receives cavity104, at least one metering cavity 105, at least one middle chamber 106A to 106G, at least one mixing chamber 107, at least oneA storage cavity 108, at least one reaction cavity 109A to 109C, at least one medium temperature control cavity 110 and/or at leastOne collection chamber 111, as shown in Fig. 1 and Fig. 2.
Storage tube 100 and/or fluid system 103 also preferably include at least one pump installation 112 and/or at least one sensingDevice configuration or sensor device 113.
Some, most of or whole cavitys preferably by storage tube 100 and/or main body 101 chamber and/or channel or itsHe forms dent, and is particularly preferably covered or be closed by the cover 102.However, other structures solution is also feasible.
In the example of displaying, storage tube 100 or fluid system 103 preferably include two metering cavities 105, it is a plurality of inBetween cavity 106A to 106G, a plurality of storage cavity 108A to 108E and/or a plurality of reaction cavity 109A to 109C, etc. excellentChoosing can load independently of one another, especially the first reaction cavity 109A, the second reaction cavity 109B and optional third reaction cavity109C, as shown in Figure 2.
(several) reaction cavity 109A to 109C especially be used to carry out amplified reaction (especially PCR) or it is several (preferablyGround is different) amplified reaction (especially PCR).Preferably parallel and/or independently and/or in differential responses cavity 109A to 109CIt is middle to carry out several (preferably different) PCR, that is, the PCR with different primers combination or primer pair.
To carry out foranalysis of nucleic acids, it is preferable that the nucleic acid sequence of the analyte A as sample P is in (several) reaction cavity109A into 109C by amplified reaction expand, especially so as to generate amplified production for sensor configuration or sensor deviceSubsequent detection in 113.
Within the meaning of the present invention, amplified reaction is especially molecular biology reaction, wherein analyte A (especially coreAcid sequence) through amplification/duplication and/or wherein generate the amplified production (especially nucleic acid product) of analyte A.It is particularly preferred thatAmplified reaction in PCR system meaning of the invention.
" PCR " represents polymerase chain reaction and is molecular biology method, and this method makes sample P using polymerase or enzymeCertain analyte A (part of especially RNA or RNA sequence or DNA or DNA sequence dna) expand (preferably several circulations), especiallyIt is then to test and/or detect amplified production or nucleic acid product.If being intended to test and/or cloning RNA, PCR is being carried outBefore, cDNA is generated since RNA especially with reverse transcriptase.Use cDNA as the template for being used for subsequent PCR.
Preferably, during PCR, it is denaturalized sample P by heating first to separate DNA or cDNA strands.Preferably, it connectsPrimer or nucleotide are deposited on the single-stranded DNA or cDNA of separation, and wanted DNA or cDNA sequence are replicated by polymeraseAnd/or it loses stock and is replaced by polymerase.This program preferably repeats a plurality of circulations, until obtain wanted quantity DNA orCDNA sequence.
, it is preferable to use labeled primer for PCR, that is, (extraly) generated on Amplification Analysis object A or amplified productionThe primer of label or label (especially biotin).This allows or promotes detection.Preferably, used primer is through biotinylationAnd/or covalently bonded biotin especially is included or formed as label.
The amplified production generated in one or more reaction cavity 109A into 109C and/or other parts of sample P canThe configuration of connection sensor or sensor device 113 are especially guided or are fed by pump installation 112.
Sensor device 113 be especially for detecting (particularly preferably qualitatively and/or quantitatively measure) sample P one orSeveral analyte A, particularly preferably nucleic acid sequence and/or protein is as analyte A in this case.Alternatively, however, orExtraly, also collect or measure other values.
As at the beginning it is stated that, especially nucleic acid sequence (preferably DNA sequence dna and/or RNA sequence) and/or protein(especially antigen and/or antibody) is preferably qualitatively and/or quantitatively measured as the analyte A of sample P.However, hereinafter,Between nucleic acid sequence and protein, or in the foranalysis of nucleic acids for detecting nucleic acid sequence and the protein for detecting proteinIt is not distinguished between analysis.
In particular, pump installation 112 especially particularly preferably wraps on the back of storage tube 100 by film or the cover 102Tubulose or pearl convex portion are included or formed, is schematically shown as shown in figure 1.
Storage tube 100, main body 101 and/or fluid system 103 preferably include plurality of channels 114 and/or valve 115A,115B, as shown in Fig. 2.
By channel 114 and/or valve 115A, 115B, cavity 104 to 111, pump installation 112 and/or sensor configuration and/Or sensor device 113 optionally or can be fluidly interconnected selectively as needed and/or temporarily and/or permanently and/or each otherFluid separation is controlled in particular so that it is waited by analysis system 1 or analysis device 200.
Cavity 104 to 111 preferably respectively links or interconnects by 114 fluid of plurality of channels.It is particularly preferred that each chamberSystem links or connects by least two association channels 114, to fill fluid can as needed, to flow through respective cavityAnd/or it is drawn from respective cavity.
Fluid conveying or fluid system 103 are preferably not based on capillary force, or are not exclusively based on these power, and especially baseThe effect of gravity and/or pumping power and/or compressing force and/or suction in sheet based on generation, Deng particularly preferably by pump orPump installation 112 generates.In this case, the flow of fluid or fluid conveying and metering system are by correspondingly unlimited and closure valve115A, 115B and/or by correspondingly especially by analysis device 200 202 pump operation of pump controller or pump installation 112 plusWith control.
Preferably, each of cavity 104 to 110 has in operating position positioned at the import at top and going out positioned at bottomMouthful.Thus it is possible to operate, if desired, being then only from the liquid of respective cavity can remove via outlet.
In operating position, the liquid of respective cavity is preferably to remove (spy via the outlet for being in bottom in each situationDo not extract), gas or air preferably can be via the inlet flows and/or pumping for being especially in top to respective cavityIn.In particular, therefore, the associated vacuum in cavity can be prevented when conveying liquid or at least minimized.
In particular, cavity (particularly preferably (several) storage cavitys 108, mixing chamber 107 and/or receiving cavity 104)It is dimensioned and/or orients in each leisure normal operating position so that when these cavitys are filled with liquid, it may potential landformAt gas or the bubble of air be raised above in operating position so that liquid collects the bubble-free above outlet.However,Other solutions are also feasible here.
Cavity 104 is received to preferably include the connector 104A for introducing sample P.In particular, sample P can be for example by shiftingLiquid pipe, syringe or other instruments and be introduced to and received in cavity 104 and/or storage tube 100 via connector 104A.
Cavity 104 is received to preferably include import 104B, outlet 104C and optional intermediate connector 104D, sample P or its portionDividing preferably further can remove and/or convey via outlet 104C and/or optional intermediate connector 104D.Gas, air or anotherOne fluid can be flowed into and/or be pumped into via import 104B, as has been described.
Preferably, sample P or part thereof can be optionally and/or depending on analyzing and going out via receiving cavity 104 wait carry outMouth 104C or optional intermediate connector 104D is removed.In particular, the supernatant (such as blood plasma or serum) of sample P can be via optionalIntermediate connector 104D is taken away or is removed especially to carry out protein analysis.
Preferably, at least one valve 115A, 115B is assigned in each cavity, pump installation 112 and/or sensor device 113The downstream for being configured in the upstream of respective import and/or respectively exporting and/or.
Preferably, cavity 104 to 111 or cavity sequence 104 to 111 (for example, fluid series connection or continue to flow through it etc.) canSelectively release and/or fluid can assign valve 115A, 115B by actuating and selectively flow through it etc. and/or these chambersBody can be fluidly coupled to fluid system 103 and/or be connected to other cavitys.
In particular, valve 115A, 115B system formed by main body 101 and film or the cover 102 and/or in another way (such asBy additional layer, dent or fellow) it is formed.
It is particularly preferred that provide one or more valve 115A, equal preferably initial or in storing state when, is closely closedIt closes, particularly preferably to seal the liquid being located in storage cavity 108 from unlimited receiving cavity 104 in a manner of stable storingOr liquid reagent F and/or fluid system 103.
Preferably, initial closure valve 115A is configured in the upstream and downstream of each storage cavity 108.These valves preferably only existWhen storage tube 100 actually uses and/or storage tube 100 is inserted into analysis device 200 in when and/or for carry out analysis andIt opens wide (especially automatically opening wide).
If especially also providing intermediate connector 104D, plurality of valves 115A in addition to import 104B and outlet 104C(being especially three valves in this case) preferably assigns in receiving cavity 104.Depending on using, except the valve on import 104BOther than 115A, the valve 115A at outlet 104C or at intermediate connector 104D is then preferably only opened wide.
It assigns in receiving especially fluidly and/or in a gastight manner enclosed fluid system 103 the valve 115A of cavity 104And/or storage tube 100, until the connector 104A of insertion sample P and closure receiving cavity 104 or the receiving cavity 104.
As the substitute of valve 115A (its equal initially closure) or in addition to valve 115A, one or more valves are preferably provided115B, Deng be not closed in a manner of stable storing and/or its etc. initially open wide and/or its etc. can be closed by actuating.These valvesEspecially for controlling the flow of fluid dduring test.
Storage tube 100 is preferably designed to microfluidic card and/or fluid system 103 is preferably designed to miniflow systemSystem.In the present invention, term " microfluid ", which is preferably understood that, means respective cavity, some cavitys or whole cavitys 104 to 111And/or the respective volume in channel 114 is less than 5ml or 2ml respectively or cumulatively, particularly preferably is less than 1ml or 800 μ l, especially600 μ l or 300 μ l are less than, Most particularly preferably less than 200 μ l or 100 μ l.
It is particularly preferred that the sample P with maximum volume 5ml, 2ml or 1ml can be introduced to storage tube 100 and/or streamIn system system 103, particularly receiving cavity 104.
It needs preferably before test with the liquid form of such as liquid or liquid reagent F and/or such as dried reagent SThe reagent and liquid that dried forms are introduced or provided are used for test sample P, as in schematic diagram according to fig. 2 by component symbol F1It is shown to F5 and S1 to S10.
In addition, other liquid F (especially in washing buffer, for the solvent of dried reagent S and/or in the form of by matter,Such as to form detection molecules and/or oxidation-reduction system) also preferably need for testing, detecting program and/or useIt is to provide in storage tube 100 in other purposes, and especially, that is, introduced (especially before delivering) equally before the use.Certain moment hereinafter do not distinguish between liquid reagent and other liquid, and therefore respectively illustrate correspondingly also phaseMutually it is applicable in.
Analysis system 1 or storage tube 100 preferably accommodate pretreatment sample P and/or carry out test or analyze and (especially carry outOne or more amplified reactions or PCR) needed for whole reagents and liquid, and therefore it is particularly preferred that only need receive optionally it is pre-The sample P of processing.
Storage tube 100 or fluid system 103 preferably include bypass 114A, can optionally employ, to may be guided when necessaryOr conveying sample P or its component are by reaction cavity 109A to 109C and/or by controlling optional medium temperature by cavity 110It is logical, also directly guide or be delivered to sensor device 113.
Storage tube 100, fluid system 103 and/or channel 114 preferably include Sensor section 116 or for detecting liquidOther devices of the flow of front end and/or fluid.
(such as channel 114, valve 115A, 115B (the valve 115A that is especially initially closed and initially it should be noted that various assembliesOpen valve 115B) and Fig. 2 in Sensor section 116) for the sake of clarity only mark in some cases, but the same symbolThe each of these components is used in Fig. 2.
Collection chamber 111 is preferably used for receiving the volume of excessive or used reagent and liquid and sample, and/or usesIn providing gas or air to empty respective cavity and/or channel.
In particular, collection chamber 111 can optionally be fluidly connected to respective cavity and channel or other devices so as to from thisA little cavitys, channel or other devices remove reagent and liquid and/or replace these reagents and liquid with gas or air.Collecting chamberBody 111 preferably gives appropriate large scale.
Once sample P has been introduced in receiving cavity 104 and connector 104A has been closed, storage tube 100 can be inserted intoIt proposes to show as shown in figure 1 in analysis device 200 so as to test sample P to proposing in analysis device 200 and/or being received in.It alternatively, also then can feed-in sample P.
Fig. 1 show in instant state with to the sample P that is received in storage tube 100 carry out test or analysis and/orAnalysis system 1 in operating position.In this state, therefore storage tube 100 is linked to analysis device 200, by analyzerPart 200 is received and/or is inserted into analysis device 200.
Hereinafter, it is based particularly on analysis device 200 is described in more detail in Fig. 1 some features and aspect first.It closesIt is preferably also proposed analysis system 1 directly under feature and aspect in the feature and aspect of the device, especially even nothing is appointedWhat further clarifies explanation.
Analysis system 1 or analysis device 200 preferably include mounting base or appearance for installing and/or receiving storage tube 100Slot 201.
Preferably, storage tube 100 fluidly (especially hydraulically) separates or is isolated with analysis device 200.In particular, storageObject cylinder 100 forms the fluid or hydraulic that is preferred independent and being especially closure or sealing for sample P and reagent and other liquidSystem 103.By this method, analysis device 200 is not contacted directly with sample P and can be especially and do not sterilizing and/or cleaning firstIn the case where be used further to another test.
However, it is provided that analysis device 200 can be mechanical, electric, warm and/or pneumatically connects or be coupled to storage tube 100.
In particular, analysis device 200 is designed to have especially for activating pump installation 112 and/or valve 115A, 115BMechanical effect, and/or be designed to have especially for (several) reaction cavity 109A to 109C and/or medium temperatureControl cavity 110 carries out temperature controlled fuel factor.
In addition, analysis device 200 is preferably pneumatically connected to storage tube 100, especially to activate individual device, and/Or may be electrically connected to storage tube 100, especially so as to for example collected from sensor device 113 and/or Sensor section 116 and/Or transmission measurement value or measurement result 713.
Analysis system 1 or analysis device 200 preferably include pump controller 202, which especially uses through designIn mechanically actuated pump installation 112.
Preferably, one of pump controller 202 can rotatably axially press the preferred pearl of pump installation 112 through rotatingConvex portion.It is particularly preferred that pump controller 202 and pump installation 112 are together especially with peristaltic pump or peristaltic pump and/or meteringThe mode of pump forms the pump for fluid system 103 and/or storage tube 100.
It is particularly preferred that the pump system constructs such as description in 10 2,011 015 184 B4 of DE.However, other structures solutionCertainly scheme is also feasible.
Preferably, the capacity of pump and/or rate of discharge can be controlled and/or pump and/or the conveying direction of pump controller 202It can be through switching.Preferably, fluid can therefore pumping forward or backward as needed.
Analysis system 1 or analysis device 200 preferably include for especially electricity and/or are thermally connected storage tube 100 and/or passThe attachment device 203 of sensor configuration or sensor device 113.
It shows as shown in figure 1, attachment device 203 preferably includes a plurality of electrical contact element 203A, and storage tube 100 is (especiallySensor configuration or sensor device 113) analysis device 200 is preferably electrically connected or may be electrically connected to by contact element 203A.
Analysis system 1 or analysis device 200 are preferably included for carrying out temperature control to storage tube 100 and/or to storingOne or more temperature control equipments of the cylinder 100 with fuel factor (especially for heating and/or cooling), should (these) temperatureControl device (respective) preferably includes heating resistor or Peltier element or is formed by its etc..
Individual temperature control equipments, these some devices or all these devices preferably it is located against or adjacent storageIt object cylinder 100, main body 101, the cover 102, sensor configuration, sensor device 113 and/or respective cavity and/or can be thermally coupled toThese and/or can integrate wherein and/or especially can by analysis device 200 it is electrically operated or control.In the example of displaying,Especially it is to provide temperature control equipment 204A to 204C.
Preferably, the temperature control equipment that will be hereinafter referred to as reaction temperature control device 204A is assigned in reaction cavityOne or a plurality of reaction cavity 109A to 109C of the 109A into 109C, especially in order to carrying out one or more whereinAmplified reaction.
Reaction cavity 109A to 109C especially relies on a common reaction temperature control device 204A or two reaction temperatureDegree control device 204A and be preferably subject to simultaneously and/or equably temperature control.
Most particularly preferably, (several) reaction cavity 109A to 109C can be not ipsilateral and/or by preferably matching from twoThe two reaction temperature control device 204A set on the opposite sides are subject to temperature control.
Alternatively, each reaction cavity 109A to 109C can independently and/or individually be subject to temperature control.
Hereinafter referred to the temperature control equipment of medium temperature control device 204B is preferably assigned controls in medium temperatureCavity 110 and/or be designed to by medium temperature control cavity 110 and/or be positioned in fluid (especially amplification produceObject) preferably (active) temperature controls or is heated to preheating temperature.
Medium temperature control cavity 110 and/or medium temperature control device 204B are preferably configured in sensor configuration or passThe upstream of sensor arrangement 113 or (immediately) sensor configure or sensor device 113 before, especially so as to the side of expectationFormula temperature controls or preheats the fluid of sensor to be fed into configuration or sensor device 113, especially analyte A and/orAmplified production, particularly preferably before feeding these fluids.
It is particularly preferred that medium temperature control cavity 110 or medium temperature control device 204B designed or provided so thatSample P or analyte A and/or the amplified production of generation denaturation, and/or any bifilar analyte A or amplified production are divided into listStock and/or the too early bond or hybridization that amplified production is especially offset by heating.
Preferably, analysis system 1, analysis device 200 and/or storage tube 100 and/or one or each temperature control equipment packetTemperature detector and/or temperature sensor (not shown) are included, it especially can to become control and/or feedback control temperatureEnergy.
One or more temperature sensors can be assigned for example in Sensor section 116 and/or be assigned in respective channel partOr cavity, that is, these can be thermally coupled to.
The hereinafter referred to temperature control equipment 204C of sensor temperature control device 204C is especially assigned in sensorDevice 113 and/or be designed to preferably desirably mode will be positioned in sensor configuration or sensor device 113 in or onFluid (especially analyte A and/or amplified production, reagent or fellow) (active) temperature controls or is heated to hybridization temperature.
Sensor temperature control device 204C is preferably flat and/or has preferably rectangle and/or correspond to sensorThe contact surface of the size of configuration or sensor device 113, the contact surface allow sensor temperature control device 204C and passHeat transmitting between sensor arrangement 113.
Preferably, analysis device 200 includes sensor temperature control device 204C.However, other structures solution is alsoFeasible, wherein sensor temperature control device 204C is incorporated into storage tube 100 (especially sensor configuration or sensor device113) in.
It is particularly preferred that attachment device 203 include sensor temperature control device 204C and/or attachment device 203 together withSensor temperature control device 204C can be linked to and (especially press against) storage tube 100, especially sensor configuration or passSensor arrangement 113.
Most particularly preferably, attachment device 203 and sensor temperature control device 204C (together) can towards and/or it is oppositeIt is mobile in storage tube 100 (especially sensor configuration or sensor device 113), and/or can be located against the storage tube, it is excellentSelection of land is coupled to storage tube 100 to make to analyze 200 electrically and thermally of device, especially sensor configuration or sensor device 113 orIts supporting element.
Preferably, sensor temperature control device 204C be configured in center on attachment device 203 or its supporting element and/Or configuration is between contact element 203A.
In particular, contact element 203A is configured in the fringe region of attachment device 203 or its supporting element or configuresAround sensor temperature control device 204C, it is preferably so that attachment device 203 is thermally connected or can be connected to sensor device 113Center and electrical connection or may be electrically connected to outside or the fringe region of sensor device 113.However, other solutions are hereinLocate also feasible.
Analysis system 1 or analysis device 200 preferably include one or more valve actuators for activating valve 115A, 115B205A,205B.It is particularly preferred that provide different (type or group) valve actuator 205A and 205B, they assign respectively inDifferent (type or group) valve 115A and 115B are to activate each of these valves.
Analysis system 1 or analysis device 200 preferably include control device 207, are used to control the sequence of test or analysisAnd/or for collecting, assess and/or export or provide especially from sensor device 113, and/or come self test results and/Or the measured value or measurement result 713 of other data or value.
Control device 207 preferably includes internal clocking (clock) or Shi Ji (time base), by the internal clocking orThe sequence of Shi Ji, test are or can be controlled, and/or rely on the internal clocking or Shi Ji, the control of control device 207 or controllableFollowed on time each other or through when the testing procedure that extends.
Control device 207 preferably controls or is designed to the actuator of control analyzer part 200 to act on storage tube100 test to carry out.Actuator is specifically for pump controller 202, temperature control equipment and/or valve actuator 205A, 205B.
Analysis system 1 or analysis device 200 preferably include one or more sensors 206A to 206H.In particular, fluidSensor 206A is designed or is provided to detect the flow of liquid front end and/or fluid in fluid system 103.Particularly preferablyGround, fluid sensor 206A be designed to (such as optics and/or capacitively) measurement or detection liquid front end and/or channel and/Or (especially assigning Sensor section 116 respectively, (it is especially by the flat of fluid system 103 and/or widens logical in cavityRoad part is formed) in) fluid presence, speed, mass flowrate/volume flow rate, temperature and/or another value.
Fluid sensor 206A preferably measures the fluid and/or Sensor section for entering or leaving Sensor section 116Changes of contents or change of fluid in 116, and the fluid entrance corresponded in Sensor section 116, fluid are generated in a programIt leaves, the measurement result 706A of changes of contents and/or change of fluid.This measurement result 706A from fluid sensor 206A canControl device 207 is retrieved and/or is transmitted to by control device 207.Control device 207 is preferably used or considers from fluidThe measurement result 706A of sensor 206A come control or be designed to control test and/or actuator.In particular, when in sensorDetected in part 116 changes of contents, into fluid, leave fluid and/or change of fluid when, before ought especially detecting liquidWhen end, control device 207 influences program sequence.In this case, for example, can be especially by with specific and/or different modesStart actuator to carry out the later step of inspection or control test.
It is particularly preferred that Sensor section 116 it is respectively oriented and/or be incorporated in fluid system 103 and/or fluid flowing warpIt crosses or is made in the operating position of storage tube 100 by Sensor section 116, fluid is in vertical direction and/or from bottomTo top flows through sensor part 116 or anti-, especially to make it possible to accurately detect liquid or to be easier.
Alternatively or additionally, analysis device 200 preferably includes one or more (different, other and/or further)Sensor 206B.
Preferably, another sensor 206B system or the pressure sensor including being used to measure (opposite) air pressure.It is anotherSensor 206B can produce measurement result 706B, be particularly corresponding to air pressure.This measurement result 706B can be by controlControl device 207 is retrieved and/or be transmitted to device 207.Control device 207 is preferably used or is considered from another sensorThe measurement result 706B of 206B come control or be designed to control test and/or actuator.
Alternatively or additionally, one or more temperature sensor 206C are provided to detect internal temperature and/or analyzerThe temperature of atmosphere in temperature in the inner space 212A of part 200, especially inner space 212A.Alternatively or additionally,There is provided one or more temperature sensor 206C with detect environment temperature and/or around analysis device 200 atmosphere temperature with/Or the temperature of one or more temperature devices.
Temperature sensor 206C preferably measures the temperature for especially analyzing the inner space 212A of device 200, and in journeyIt is generated in sequence and corresponds to the especially atmosphere of inner space 212A and/or inner space 212A or the measurement knot of partial temperatureFruit 706C.This measurement result 706C from temperature sensor 206C can retrieve and/or be transmitted to control by control device 207Device 207.Control device 207 is preferably used or considers the measurement result 706C from temperature sensor 206C to control or pass throughDesign is to control test and/or actuator.
Analysis device 200 preferably includes inclination for testing and analyzing device 200 and/or storage tube 100 and/or orientationInclination sensor 206D.Inclination sensor 206D is especially designed and is arranged to determine analysis device 200 and/or storage tube100 inclination, the inclination being different from operating position.
Inclination sensor 206D preferably measures inclination, and generates correspond to analysis device 200 and/or storing in a programThe inclined measurement result 706D of cylinder 100.This measurement result 706D from inclination sensor 206D can be by control device 207Retrieve and/or be transmitted to control device 207.Control device 207 is preferably used or considers the survey from inclination sensor 206DResult 706D is measured to control or be designed to control test and/or actuator.In particular, prevented if inclination is excessive, prevent orInterrupt test, and/or identify, handle, transmit and/or signal mistake.
Analyzing device 200 may include acceleration transducer 206E.Acceleration transducer 206E is preferably designed to surveyThe acceleration of setting analysis device 200, especially with respect to operating position vertically and/or horizontally on acceleration.
Acceleration transducer 206E preferably measures acceleration, and in a program generate correspond to analysis device 200 and/orThe measurement result 706E of the acceleration of storage tube 100.This measurement result 706E for carrying out acceleration sensor 206E can be by controlControl device 207 is retrieved and/or be transmitted to device 207 processed.Control device 207 is preferably used or considers from acceleration sensingThe measurement result 706E of device 206E come control or be designed to control test and/or actuator.In particular, if acceleration is excessive,It then prevents, prevent or interrupt test, and/or identify, handle, transmit and/or signal mistake.
Analysis device 200 may include for measure in (opposite) atmospheric humidity and/or inner space 212A or in and/or divideThe humidity sensor 206F of the dew point of atmosphere outside parser part 200.
Humidity sensor 206F preferably measures (opposite) atmospheric humidity and/or dew point, and generates correspond in a program(opposite) atmospheric humidity and/or analysis device 200 in and/or analysis device 200 ambient enviroment atmosphere dew point measurementAs a result 706F.This measurement result 706F from humidity sensor 206F can retrieve and/or be transmitted to control by control device 207Device 207 processed.Control device 207 be preferably used or consider the measurement result 706F from humidity sensor 206F controlling orIt is designed to control test and/or actuator.In particular, if (opposite) if atmospheric humidity is excessively high and/or approach or arrive at dew point,It then prevents, prevent or interrupt test, and/or identify, handle, transmit and/or signal mistake.
Analysis device 200 may include the position sensor 206G for for example determining position or place by GPS sensor.Position sensor 206G is preferably designed to determine the ground of analysis device 200 (especially at the earth's surface on) in spacePoint, and/or geographical location, place and/or the coordinate of output analysis device 200.
The position (especially geographical location) of position sensor 206G preferably measurement analyzer part 200, and in a programGenerate the measurement result 706G for corresponding to position or geographical location.This measurement result 706G from position sensor 206G can be byControl device 207 is retrieved and/or is transmitted to by control device 207.Control device 207 is preferably used or considers to be passed from positionThe measurement result 706G of sensor 206G come control or be designed to control test and/or actuator.
Analysis device 200 may include for measuring or checking storage tube 100 in analysis device 200 or relative to analyzerThe position of part 200 or the storing cylinder sensor 206H of alignment.In particular, storing cylinder sensor 206H is designed to detection storage tube100 out of position in analysis device 200.Alternatively or additionally, storing cylinder sensor 206H be designed to detection and/Or correct and/or operating position of the verifying storage tube 100 in analysis device 200.
Storing cylinder sensor 206H preferably measures position of the storage tube 100 in analysis device 200, and produces in a programThe measurement result 706H of the raw position for corresponding to storage tube 100 in analysis device 200 or alignment.From storing cylinder sensorThis measurement result 706H of 206H can retrieve and/or be transmitted to control device 207 by control device 207.Control device 207 is excellentSelection of land using or consider the measurement result 706H from storing cylinder sensor 206H come control or be designed to control test and/orActuator.In particular, preventing from or preventing to test and/or store up if storage tube 100 is incorrectly positioned in analysis device 200Object cylinder 100 is automatically from analysis device 200 or fellow's pop-up.Alternatively or additionally, if detecting storage tube 100 in analyzerIt is in proper manipulation locations in part 200, then enables test.
The preferred control of control device 207 or feedback control pump controller 202, temperature control equipment 204 and/or valve actuator205, it especially considers or depending on to be tested and/or from sensor configuration or sensor device 113 and/or sensorThe measured value of 206A to 206H.
The flow of fluid is especially by correspondingly starting pump or pump installation 112 and actuating valve 115A, 115B are controlled.
It is particularly preferred that pump controller 202 includes stepper motor or the driver calibrated in another way, so that can be at leastReach to be measured by appropriate starting in principle.
Additionally or alternatively, fluid sensor 206A is for 116 cooperative detection of Sensor section especially with appointmentThe flow of liquid front end or fluid, so as to by correspondingly control pump or pump installation 112 and correspondingly trigger valve 115A, 115B andReach wanted fluid sequence and to be measured.
Optionally, analysis system 1 or analysis device 200 include input unit 208 (such as keyboard, Touch Screen or similarPerson) and/or display device 209 (such as screen).
Analysis system 1 or analysis device 200 preferably include for example for controlling, for transmitting and/or for exporting measurementData or test result and/or for be linked to other devices (such as printer, external power supply or fellow) at least oneInterface 210.It can be wired or wireless interface 210 that this, which is especially,.
Analysis system 1 or analysis device 200 preferably include power supply 211, preferably battery or accumulator, are especiallyIt is integration and/or external connection or attachable.
Preferably, integrate accumulator be provided as power supply 211 and can by external charging device (not shown) via evenFitting 211A (again) charging and/or it is interchangeable.
Analysis system 1 or analysis device 200 preferably include shell 212, and all components and/or some or all devices are preferredIt is incorporated into shell 212.It is particularly preferred that storage tube 100 can be inserted into or be slid into shell 212, and/or can be by analyzerPart 200 is received through the opening 213 (such as slit or fellow) that can be especially closed.
Analysis system 1 or analysis device 200 are preferably portable or mobile model.It is particularly preferred that analysis 200 weight of deviceLess than 25kg or 20kg, particularly preferably be less than 15kg or 10kg, especially less than 9kg or 6kg.
Storage tube 100 will be described in greater detail subsequently and analyze fluid (especially pneumatic) coupling between device 200It closes, following aspect can independently of aforementioned aspects be implemented.
As has been described, analysis device 200 is preferably pneumatically linked to storage tube 100, is especially linked to sensor and matchesIt sets or sensor device 113 and/or is linked to pump installation 112.
It is particularly preferred that analysis device 200 is designed to (the especially sensor configuration or sensor dress of storage tube 100Set 113 and/or pump installation 112) supply working media (especially gas or air).
Preferably, working media can be in analysis device 200 or by the compression of analysis device 200 and/or pressurization.
Preferably, analysis device 200 includes 214 (especially pressure generator of gas-pressurized power supply unit for this purposeOr compressor), preferably for compression and/or pressurised working medium.
Gas-pressurized power supply unit 214 is preferably incorporated into analysis device 200 or shell 212 and/or can be by control dressIt sets 207 and carries out control or feedback control.Gas-pressurized power supply unit 214 can also be at least partially formed on storage tube 100 or byThe formation of storage tube 100.
Preferably, gas-pressurized power supply unit 214 is electrically operated or can be by electric power operation.In particular, power supply 211 can be relied onAnd electric power is supplied to gas-pressurized power supply unit 214.
Analysis device 200 or gas-pressurized power supply unit 214 are preferably designed to for working media being compressed to100kPa, particularly preferably more than 150kPa or 250kPa, particularly more than 300kPa or 350kPa, and/or be less than 1MPa, spy900kPa or 800kPa, particularly pressure less than 700kPa and/or the medium You Xuandi little Yu not be fed at this pressureTo storage tube 100.
Preferably, air can especially be sucked from ambient enviroment by analysis device 200 or gas-pressurized power supply unit 214As working media.In particular, analysis device 200 or gas-pressurized power supply unit 214 are designed to use ambient enviroment as workMake the storage device of medium or air.However, other solutions are also feasible here, especially wherein analyze device 200 or addPressure gas supply device 214 includes the preferred closure containing working media or delimits storage device (such as slot or container) and/or connectOr it can be connected to its solution.
Preferably, analyzing device 200 or gas-pressurized power supply unit 214 includes import, and working media especially can be viaImport is sucked and/or is guided in gas-pressurized power supply unit 214.
Preferably, analyzing device 200 or gas-pressurized power supply unit 214 includes filter, which is preferably incorporated intoIn import and/or preferably working media can be filtered by the filter and/or preferably particle can by the filter and withWorking media separation.
Filter is preferably designed to micro-filter or is finely particulate air filter.Preferably, have more than 10 μM, particularly preferably more than 8 μm or 9 μm, particularly more than 6 μm or 7 μm, the Most particularly preferably partial size more than 4 μm or 5 μmParticle can be separated by filter, and partial size is preferably the maximum or average diameter of respective particle.This ensures transportation work mediumStorage tube in channel or pipeline will not be contaminated or block and/or be not in non-wanted pressure loss.
Analysis device 200 or gas-pressurized power supply unit 214 preferably include connecting element 214A, especially so as to by analyzerPart 200 and/or gas-pressurized power supply unit 214 are pneumatically coupled to storage tube 100.
Fig. 3 system is used to test the schematic diagram of especially the proposed analysis system 1 of biological sample P, and analysis system 1 includes usingIn the analysis device 200 receiving storage tube 100 and then testing using the receiving storage tube 100 implementation, and it is used for the analyzerThe operation instrument 400 of part 200.
Operation instrument 400 is preferably designed to control analyzer part 200.Alternatively or additionally, operation instrument 400 canInformation is received or retrieved from analysis device 200, especially (is measured) as a result, such as measured value.In particular, operation 400 system of instrumentMobile terminal device, such as intelligent telephone, tablet computer or fellow.
Operation instrument 400 is preferably implemented or is provided physically to separate with analysis device 200.Operate instrument 400Preferably physically and/or relative to data connection with analysis device 200 separates and/or disconnect.
Operation instrument 400 is preferably wirelessly connected to analysis device 200.It therefore, can be in analysis device 200 and operation instrumentData connection DVA is established between device 400.However, data connection DVA can also be established in principle with another way (such as wired).
Operation instrument 400 preferably with analysis device 200 separate or disconnect when be also it is operable, be especially used forCarry out assessment or for other purposes.Alternatively or additionally, analysis device 200 is separating or is disconnecting company with operation instrument 400Be also when connecing it is operable, especially for continuing to test.
It is particularly preferred that operation instrument 400 includes the interface 430 for establishing data connection DVA, DVB, DVD.Interface430 and/or operation instrument 400 be especially include be known as analyze device interface 431 interface, be designed to analysis device200 establish preferred wireless data connection DVA.This can for example be radio interface, WPAN interface, blue tooth interface and/or bluetooth mouldBlock or fellow.
The interface 210 of analysis device 200 preferably corresponds to the interface 430 and/or analysis device interface of operation instrument 400431, in particular so that operation instrument 400 can be established and analyze the data connection DVA between device 200.Analysis device 200 connectsMouth 210 and analysis device interface 431 preferably support identical data transmission method and/or radio transmission method or radio markStandard, especially WLAN or WPAN method, such as bluetooth, NFC, Zigbee or fellow.
It is particularly preferred that the interface 210 and analysis device interface 431 of analysis device 200 are realized or promote to be known as dedicated companyConnect the connection of (ad-hoc connection).In this case, when device (that is, operation instrument 400 and analysis device 200) existsWhen in the range of each other, data connection DVA is preferably established automatically.In other words, it operates instrument 400 and analysis device 200 is respectiveWireless data interface 430,210 is respectively included, etc. being designed to combine and build between operation instrument 400 and analysis device 200Vertical exclusive data connection is preferably so that when operation instrument 400 and analyzes device 200 in space close to that at this point, therebetweenData connection DVA is established automatically and is preferably shown by operation instrument 400.
Data connection DVA is preferably point-to-point connection.Data connection DVA is preferably directly and/or without any insertionAnalysis device 200 is connected to operation instrument 400 in the case where network.Operating instrument 400 can simultaneously or successively divide from differentParser part 200 establishes data connection DVA.Alternatively or additionally, analysis device 200 can simultaneously or successively with it is a plurality ofOperation instrument 400 establishes data connection DVA.
For control test, it is preferable that in the operation instrument 400 of analysis device 200 to be controlled and control the analysis device 200Between a lucky data connection DVA is provided, and/or receive and/or receive or should be subjected to and/or can receive control information510 and/or only via it is to be controlled analysis device 200 and control the analysis device 200 operation instrument 400 between it is proper what aData connection DVA is transmitted or can transmission measurement result 713.
Analysis device 200 is preferably included for the receiver from operation instrument 400 preferably wireless receiving control information 510210A.Preferably, interface 210 includes receiver 210A, via receiver 210A, signal (especially control information 510) systemOr it can be received from operation instrument 400.
Alternatively or additionally, analyzing device 200 and/or interface 210 includes transmitter 210B, via the transmitter210B, data (especially as a result, measurement result 713) such as from sensor device 113 system or can particularly preferably sendTo operation instrument 400.
Interface 210,431 preferably corresponds to each other so that its etc. supports identical data transmission standard and/or radio markStandard, especially bluetooth, WLAN or fellow.These interfaces are particularly preferably the interface for realizing the connection for being known as dedicated connection210,431, data are preferably established automatically when in the range of device (that is, operation instrument 400 and analysis device 200) is each otherConnect DVA.
Analysis system 1 preferably further comprises database 500 or assigns database 500 in analysis system 1.Database500 be preferably external data base 500, implemented or provide so as to physically with operation instrument 400 and/or with analysis device200 separation.However, in principle, database 500 can not be provided or be implemented so that it especially can directly be linked to behaviourMake instrument 400, or provides or implement by operation instrument 400.
Database 500 can be accessed via data connection DVD by operating instrument 400.For this purpose, operate instrument 400 and/orInterface 430 may include database interface 432, rely on database interface 432, can be especially and access database 500 via network N.Network N can be Internet or another data network.Also preferably, operation instrument 400 can be via wireless interface (especiallyWLAN, WPAN, mobile communication or fellow) and data connection DVD is established with database 500.However, in principle, other solutionsScheme is also feasible here.
It is particularly preferred that operation instrument 400 includes distinct interface 430, it is equal independently of one another with analysis device 200 and severalEstablish data connection DVA, DVD according to library 500, analysis device 200 (peripheral devices as operation instrument 400) be designed to orIt is uniquely communicated via operation instrument 400.
Analysis system 1 (especially database 500) preferably includes control information 510, by control information 510, analyzerPart 200 can be controlled to carry out test.
The preferably actuating of the actuator of defined analysis device 200 in a specific way of information 510 is controlled, so that in storage tubeTest sample P in 100.In particular, the actuator for carrying out test may or be to be controlled such that using control information 510These actuators act on storage tube 100 and/or sample P.These actuators be especially pump controller 202 and/or one orMultiple temperature control equipments 204 and/or one or more valve actuators 205.Control information 510 is preferably included to be used for carrying outIn the parameter and/or instruction of the one or more steps for the method for testing sample P described above.
Preferably, analysis system 1 includes calibration information 520, can be stored in database 500 and/or can be from database500 retrievals.Calibration information 520 is preferably able to influence the test of sample P, is particularly depending on specific storage tube 100, depends onThe storage tube batch of specific storage tube 100 and/or depend on fc-specific test FC.
It is for sensor (such as sensor device 113 of storage tube 100), for analyzing that calibration information 520, which is especially,The one or more of (several) the sensor 206A to 206H of device 200 and/or default or base for one or more actuatorsThis setting, parameter and/or threshold value.
In addition to controlling information 510, also it can be used calibration information 520 to carry out test, calibration information 520 preferably influencesOr specified control information 510.Calibration information 520 can be or can be formed control information 510 or the control information 510 a part,Even if this is hereinafter not expressly mentioned.
Analysis device 200 can be calibrated by the calibration information 520 that can be formed the part of control information 510 or can be provided separatelyAnd/or configuration.For this purpose, calibration information 520 can determine by operation instrument 400, retrieve and/or be transmitted to analysis device200。
In an example, fluid sensor calibration information 521 is provided, influence fluid sensor 206A setting and/Or assessment.Fluid sensor calibration information 521 preferably depends on test to be carried out, the stage of test and/or testing sequenceThe intended effect of changes of contents in period Sensor section 116, and/or contain the various specifications for depending on it.
Alternatively or additionally, it is possible to provide inclination sensor calibration information 524 preferably includes one or more threshold values525, especially: starting threshold value 526, be used to prevent the starting of test in the case where being more than the threshold value；And/or outage threshold527, it is used for the interrupt test and/or for handling mistake in the case where being more than the threshold value.
Alternatively or additionally, it is possible to provide sensor configures calibration information 528, configures calibration information 528 by sensor,Sensor configuration or sensor device 113 property system or can be set.Especially, it is provided that sensor configures calibration information 528System is by the transmission of analysis device 200 or can be transmitted to sensor configuration or sensor device 113, and sensor configuration or sensorDevice 113 is carried out or is designed to carry out the measurement for considering sensor configuration calibration information 528.
Itd is proposed analysis system 1 preferably includes assessment information 530, is stored in database 500 and/or can retrieve or canIt is retrieved from database 500.Assessment information 530 is preferably designed to explain derived from storage tube 100 (especially derived from sensingDevice device 113) measurement result 713.
Control information 510 and/or assessment information 530 particularly preferably include instruction, preferably in the form of algorithm and/Or program on control processor or controller or for controlling the program for using processor or controller to carry out.It instructs excellentIt may or be that therefore, can be changed or change and divide by analyzing device 200 and/or operating the module of the implementation of instrument 400 that selection of land, which is formed,Parser part 200 and/or the behavior for operating instrument 400.
Instruction is especially order, machine code, precompile source code or source code.Instruction preferably forms module shape software groupPart, especially plug-in unit.Instruction can be designed to be formed and/or replacement operation instrument 400 and/or the module for analyzing device 200.OutIn this purpose, controls information 510 and/or assessment information 530 may include for by control device 207 and/or operation instrument 400Evaluation module 440 coupling or implement (software) interface.
Control information 510 particularly preferably includes or forms the mould of the control device 207 preferably exchanged in terms of softwareBlock.This module preferably comprise for control test instruction (such as logical order, circulation and fellow), especially in byAnalyze the form of computer program or computer program product that device 200 and/or control device 207 are carried out.Control information 510It can be or form the commutative part of control device 207 (especially as plug-in unit).
Evaluation module 440 is preferably formed by operation instrument 400 or operation instrument 400 includes evaluation module 440.Rely onEvaluation module 440, it is preferred to use assessed from the assessment information 530 of the retrieval of database 500 from the reading of sensor device 113Measurement result 713 and/or evaluation module 440 are designed for this purpose.
Assessment information 530 particularly preferably includes or forms the mould of the assessment device 440 preferably exchanged in terms of softwareBlock.This module preferably comprises the instruction (such as logical order, circulation and fellow) of the assessment for controlling measurement result 713,Especially in the shape of computer program or computer program product to be carried out by operation instrument 400 and/or evaluation module 440Formula.Assess the commutative part spy (being used as plug-in unit of fixed speech) that information 530 can be or form evaluation module 440.Computer programProduct is preferably non-transitory computer-readable media.
Alternatively or additionally, instruction may include the parameter for configuring control device 207 and/or evaluation module 440.It removesAlso preferably provide these parameters for example for analyzing device 200 other than instruction, these parameters in the form of calibration information 520 orIncluding calibration information 520.Alternatively, however, control information 510 and/or assessment information 530 also can only include for control and/Or the parameter and/or other information of assessment.
Database 500 preferably includes result memory 550, can store and/or save result.
Within the meaning of the present invention, term " database " should preferably understand in a broad sense and also especially be incorporated to multi-section pointDatabase.Therefore, in principle, database 500 may be provided in different entities unit or in different location and/or can be by plural numberA subdata base is constituted.
Operation instrument 400 preferably separates and/or breaks with analysis device 200 relative to data connection and/or physicallyOpen connection.For this purpose, analysis device 200 initially can be connected to operation instrument 400 by data connection DVA is established.
For control test and/or analysis device 200, operation instrument 400 can from database 500 retrieve control information 510 andWith do not change or altered form by the information be transmitted to analysis device 200.
Operation instrument 400 be preferably designed to assessment of the measurement result 713, preferably in test sample P byThe sensor device 113 of storage tube 100 generates.For this purpose, it is provided that may originate from the sensor device 113 of storage tube 100And/or it can be transmitted to 713 system of measurement result of operation instrument 400 from analysis device 200 or can be assessed in operation instrument 400.For this purpose, operation instrument 400 can retrieve or receive assessment information 530 from database 500 and use this assessment information 530,The assessment of the measurement result 713 especially in the evaluation module 440 of operation instrument 400.
Operation instrument 400 preferably includes memory 450.Memory 450 can be used at least temporarily storing control information 510,Calibration information 520 and/or assessment information 530, or operation instrument 400 and memory 450 can be designed for this purpose.AlternativelyOr extraly, or from the assessment result 740 that measurement result 713 generates memory 450 can be stored in by operation instrument 400In.
In an example, operation instrument 400 includes output device 410, preferably especially touch sensitive screen or display411 and/or loudspeaker 412.Alternatively or additionally, operation instrument 400 includes input unit 420, especially camera 421, touchingControl plate 422, microphone 423 and/or keyboard 424.
Operation instrument 400 is preferably designed to show via output device 410 (especially screen or display 411) and graspMake interface or User's Interface, or the operating element for controlling test and/or analysis device 200 is provided in another way, and/Or output state or the other information about test.Alternatively or additionally, it can receive and order via input unit 420, rely onInput unit 420, operation instrument 400 start, configure and/or control the test of sample P in a manner of corresponding to order.
Preferably, the transmission system of order and/or information to analysis device 200 triggers via input unit 420 or can be byInput unit 420 triggers.
In particular, control information 510 can be originated or be controlled from operation instrument 400 to analysis device via input unit 420200 transmission.Alternatively or additionally, analysis device 200 can be controlled to receive storage tube 100 and/or to be preferably usedIt controls information 510 and/or starts test via the received order of input unit 420.Therefore, operation instrument 400 preferably passes throughDesign is to be transmitted to analysis device 200 for the control information 510 for being used to receive or pop up storage tube 100.In this case, storingCylinder 100 can be especially the only insertion when operating instrument 400 and being connected to analysis device 200, if therefore detecting such as incompatibilityMistake, then operate instrument 400 can verify that storage tube 100 and can pop up the storage tube or prevent test.
Alternatively or additionally, operation instrument 400 is designed to for the control information 510 for being used to start test to be transmitted to pointParser part 200.It is therefore preferred to only start by the order derived from operation instrument 400 for the test.It is excellent to analyze device 200 itselfChoosing does not include the User's Interface for generating starting command or for leading to test start.This task is preferably to operate instrument400 retain.
Storage tube 100 preferably includes at least one storage tube identifier 100C, correspond to storage tube 100 and/or with storageThe associated batch of object cylinder 100.
Storage tube identifier 100C is especially to be specific to one of related storage tube 100 information, it is especially unique and/orIt is designed to uniquely identify storage tube 100, such as assign in related storage tube 100 and allows the storage tube preferably uniqueness sideThe identification code of formula identification.
Alternatively or additionally, storage tube identifier 100C can assign storage tube 100 special in production cycle and/or a batchDetermine storage tube 100.A batch is less preferably characterized in that storage tube 100 was produced and/or is produced into the identical continuous production periodWith same components (especially there is identical sensor device 113 and/or identical reagent and fellow).There is preferably mayA plurality of batches different from each other about production cycle, raw materials batch and fellow, such as.
Storage tube identifier 100C can be stored and/or be stored in the memory device 100D of storage tube 100.Memory deviceSetting 100D can be bar code 124, NFC label and/or memory, provided in sensor device 113, be connected to sensorDevice 113 is assigned in sensor device 113, or another device for storing code or fellow.
Storage tube identifier 100C is preferably assigned in respective storage tube 100.In particular, storage tube identifier 100C systemIt is formed by storage tube 100, is connected to storage tube 100 and/or configuration on storage tube 100.
Analysis system 1 may include one or a plurality of storage tubes 100, etc. respectively can preferably relying at least one storingCylinder identifier 100C be distinguished from each other and/or its etc. it is assigned in a batch.
The another aspect that can also independently implement of the invention is related to storage tube 100, has and respectively correspond tos the storingAt least two storage tube identifier 100C of cylinder 100.Storage tube identifier 100C is preferably (special by different read methodsBe optically, by radio, by wired connection or fellow) read.
Respective storage tube 100 may include two different memory devices with identical or corresponding storage tube identifier 100C100D.Memory device 100D is preferably separated from each other independently of one another and/or physically.Memory device 100D preferably withDifferent modes (on the one hand especially connect electronically and/or by electronics, and on the other hand wirelessly (especially optically and/Or by radio)) read.
In the example of displaying, corresponding storage tube identifier 100C system storage saves or is recorded in especially sensor dressIt sets in 113 memory that can electronically read, and (special in the memory that can be wirelessly read (by radio or optically)It is not bar code 124) in.This, which allows, corresponds to one of identical storage tube 100 or several storage tube identifier 100C differenceMode is read.
This advantageously can to disconnect ground or discretely (preferably independently of analysis device 200, with analysis device 200Storage tube identifier 100C is optically read by from storage tube 100 in ground) control information 510, calibration letter are retrieved from database 500Breath 520 and/or assessment information 530.Alternatively or additionally, the memory device 100D that can electronically read of storage tube 100So that can for example when the storage tube be inserted into analysis device 200 in when there is no connect with the optics of storage tube 100 or with storageStorage tube identifier 100C is read in the case where the visual touch of object cylinder 100.
At least two storage tube identifier 100C can be identical, or in the one aspect that can also independently implement of the inventionIn, these storage tube identifiers 100C can be different.In particular, (first) storage tube identifier 100C is for storage tube 100It may and be preferably individual or unique, that is, be designed to uniquely identify storage tube 100.(difference or second) storage tubeIdentifier 100C is preferably designed to assign storage tube 100 in a collection of storage tube 100.At least two storage tube identifiers100C is preferably corresponded to each other.In particular, corresponding to the storage tube identifier 100C of batch and/or batch can be used uniquelyThe storage tube identifier 100C of storage tube 100 is identified to identify.Preferably, storage tube identifier 100C is read and uses, especiallyIt is on the one hand to measure and/or retrieve control information 510 and/or assessment information 530 and on the other hand to verify these lettersBreath.
Respective storage tube 100 preferably identifies at least twice or storage tube identifier 100C reads and uses at least twice,I.e. preferably for the first time directly by operation instrument 400 realize so as to retrieve control information 510 and/or calibration information 520 and/orIt assesses information 530 and relies on for the second time or realize via analysis device 200 to ensure using the control for corresponding to storage tube 100Information 510, calibration information 520 and/or assessment information 530 are to carry out test and/or to ensure and/or access control information510, calibration information 520 and/or assessment information 530 correspond to storage tube 100.
Fig. 4 show by proposed analysis system 1 (especially in a manner of depending on individual storage tubes 100) test with/Or the schematic sequence of the preferred method of assessment.Following aspect and/or method and step also can be implemented and can preferably individually or be inDifferent combinations, described sequence is preferred but does not force, and step can be omitted or add or independently carries out.
It is such as described above, at least one storage tube identifier 100C corresponds to (respective) storage tube 100.This storage tube markKnow symbol 100C to be preferably stored in the memory device 100D on storage tube 100, especially bar code 124 and/or sensorThe memory born of the same parents of device 113.However, in principle, other storage options are feasible here or there are other memory devices of offerThe option of 100D.For example, assigning in the encapsulation that the memory device 100D of storage tube 100 is configurable on storage tube 100 or canForm the part of the encapsulation.
Preferably, (the especially sensor device 113) system of storage tube 100 and analysis device 200 are in electrical contact.This be preferably byReached by one or more contact element 203A, is shown as shown in figure 1 by example.
If storage tube identifier 100C is stored in sensor device 113 or is assigned in sensor device 113, the storageObject cylinder identifier 100C can by analysis device 200 via can rely on contact element 203A establish between storage tube 100 with pointData connection DVC between parser part 200 is read.This is indicated by arrow 601, is indicated from storage tube 100 to analysis device 200Data transmission.It is stored in sensor device 113 and/or assigns the storage tube identifier 100C in sensor device 113 excellentSelection of land identifies storage tube 100 uniquely or on one-to-one basis.
The storage tube identifier 100C read by analysis device 200 from storage tube 100 can be via analysis device 200 and behaviourMake the data connection DVA between instrument 400 and be transmitted to operation instrument 400, as indicated in Fig. 4 by arrow 602, indicates analysisData between device 200 and operation instrument 400 are transmitted.In addition to storage tube identifier 100C, device identifier 200C also may be usedOptionally operation instrument 400 is transmitted to from analysis device 200.Device identifier 200C preferably corresponds to particular analysis device 200And/or to can recognize the analysis device 200.
In it one of also can extraly carry out alternative, storage tube identifier 100C system or may be by operation instrument 400It directly determines.It is particularly preferred that this is optically and/or to use the camera 421 of operation instrument 400 (preferably by reading oneCode, especially bar code 124) Lai Dacheng.However, also can be by operation instrument 400 in some other way (such as by wirelessElectricity especially optionally assigns in storage tube 100 by reading or configures RFID label tag or NFC memory on storage tube 100Device assigns the part of formation storage tube 100 on storage tube 100 or in some other way in storage tube 100 and configurationFellow) storage tube identifier 100C directly and/or is wirelessly determined from related storage tube 100.
Therefore, therefore storage tube identifier 100C particularly preferably reads the storage of storage tube 100 by operation instrument 400Device device 100D and directly, or by data accordingly transmit via analysis device 200 and be transmitted to operation instrument indirectly400, and operate instrument 400 and receive or determine storage tube identifier 100C whereby.
In the one aspect that can also independently implement of the invention, operation instrument 400 relies on storage tube identifier 100CReceive or determine that preferably storage tube is specific and/or the specific information of storage tube batch, or operation instrument 400 is designed for thisPurpose.
Operation instrument 400 is retrieved or is designed to retrieval (preferably automatic) and is used for control analyzer part 200 to carry outBy the control information 510 of the test of the support of storage tube 100 and/or for by the storage tube identifier for reading storage tube 100The analysis information of 100C or the measurement result 713 measured during assessment test after having read storage tube identifier 100C530。
Especially, it is provided that operation instrument 400 is based on storage tube identifier 100C and receives or retrieve control information 510, the letterBreath is specific to storage tube 100, its batch and/or is specifically used for being carried out test using storage tube 100.It is particularly preferred that controlInformation 510 is retrieved or can be retrieved from database 500 from database 500.
Preferably, storage tube identifier 100C is transmitted to database 500, right as indicated in Fig. 4 by arrow 603The data that Ying Yucong operates instrument 400 to database 500 are transmitted.
Database 500 can be sent back to corresponding to storage tube 100 and/or corresponding to the control information of storage tube identifier 100C510, that is, by the information be transmitted to operation instrument 400, if in Fig. 4 by arrow 604 indicate, indicate between database 500 withOperate the data transmission between instrument 400.
Alternatively or additionally, calibration information 520 and/or assessment information 530 can also be from databases 500 to operation instrument400 corresponded manner is transmitted to operation instrument 400 or is or can retrieve by operation instrument 400 from database 500.
In a variant, which can also examine in the case where no storage tube identifier 100C is transmitted to database 500Rope.In a variant of this type, it can be used for operating instrument 400 and for example previously retrieved and/or be temporarily stored in behaviourStoring can be based on by operation instrument 400 by making the control information 510 in instrument 400, calibration information 520 and/or assessment information 530Cylinder identifier 100C is identified and be can be chosen for then using.
Two of information 510, calibration information 520 and/or assessment information 530 can be being controlled with for determining and/or retrievalIn the another variant of prior method combination, information system is in addition by the device for using and/or transmitting analysis device 200 for identificationIdentifier 200C and/or the operation instrument identifier 400C for operating instrument 400 for identification are selected and/or are retrieved.This makesInformation 510, calibration information 520 and/or assessment information 530, which must be controlled, can be specific to analysis device 200 and/or operation instrument 400Or with analysis device 200 and/or operation instrument 400 it is compatible and make the information can be specific to it analysis device 200 and/or behaviourMake instrument 400 or with analysis device 200 and/or operate the compatible mode of instrument 400 by selection, transmission, retrieve and/or send back to.
Preferably, it retrieves or determines control information 510, correspond to both storage tube 100 and analysis device 200, especiallyIt preferably corresponds to storage tube 100 and analyzes the combination of device 200.Therefore, which can be specific to storage tube 100 and analysisThe mode of both devices 200 is carried out, and this helps to keep test height repeatable and reliable.
In the one aspect that can also independently implement of the invention, preferably correspond only to associated with storage tube 100The storage tube identifier 100C of batch determined first by operation instrument 400, be especially or can be straight by operation instrument 400It connects from storage tube 100 and reads.
Using storage tube identifier 100C, especially by the operation retrieval of instrument 400 control information 510 and/or assessment letterBreath 530.It retrieves control information 510 and/or preferably temporary be stored in of assessment information 530 operates in instrument 400.
Control information 510 is preferably transmitted to analysis device 200 or operation instrument 400 through designing by operation instrument 400For this purpose.This is indicated in Fig. 4 by arrow 605, corresponds to the data from operation instrument 400 to analysis device 200Transmission.
Optionally, calibration information 520 can also be transmitted to analysis device 200 from operation instrument 400.Alternatively or additionally, it graspsCalibration information 520 can be considered especially to modify control information 510 by making instrument 400.However, control information 510 also can includeOr it is incorporated to calibration information 520.Therefore, forced transport does not extremely analyze device 200 to calibration information 520.
Preferably, only the case where having verified that storage tube 100, control information 510 and its appointment, association and/or compatibilityUnder transmitted.This ensures that control information 510 to be transmitted corresponds to the storage tube 100 for being intended for carrying out test.This is spyIt is not previously to have retrieved and/or be temporarily stored in operation by operation instrument 400 in control information 510 and/or assessment information 530It is provided in the case where in instrument 400.
Verifying system particularly preferably reaches by one/storage tube identifier 100C.In particular, in order to verify, using notIt is same as the storage tube identifier 100C of the storage tube identifier for retrieving control information 510 and/or assessment information 530, and/orUse the storage tube identifier 100C read from another memory device 100D of storage tube 100.
Preferably rely on or to verify the storage tube identifier 100D provided via the reading of analysis device 200 and/or transmissionTo operation instrument 400.This is in the case where storage tube 100 is directly contacted with analysis device 200 to carry out test (that is, in storingIn the case that cylinder 100 is especially loaded or is inserted into analysis device 200) it carries out.This, which ensures to determine, is intended for carrying out testStorage tube 100.Therefore, the verifying by the storage tube identifier 100C of storage tube 100 is so that can ensure that using corresponding to storageThe control information 510 of object cylinder 100 is tested to carry out.
Verifying can by check for the storage tube identifier 100D that provides of verifying it is assigned in control information 510 and/or byIt is assigned in for determining the storage tube identifier of control information 510 to verify the storage tube identifier 100C provided by checking100C and reach.In this regard, it can check to verify whether the storage tube identifier 100C provided corresponds to control 510 institute of informationThe batch of corresponding storage tube 100.This can be by appointment, distribution or mapping (such as table or database) and/or by appointmentIn or formed control information 510 part verifying device and reach.For this purpose, control information 510 may include that correspondence refers toSend device, such as the information about storage tube identifier group.Device can be assigned to carry out verifying by these.
Other retrieval information (especially assessment information 530) can be verified with corresponded manner.
Controlling information 510 can receive and for controlling test by analysis device 200.Alternatively or additionally, control letterBreath 510 can also be verified in analysis device 200.
After having transmitted control information 510, test preferably is started in a manner of controlling by operation instrument 400.
In Fig. 4, the test program analyzing device 200 and carrying out to storage tube 100 is relied on by the instruction of arrow 606.
Also the one aspect according to the present invention that can be independently implemented, analysis device 200 are designed to the control using transmissionInformation 510 processed and independently of operation instrument 400 and/or with operation instrument 400 discretely and/or with disconnecting carry out testAnd/or the test system discretely and/or with disconnecting carries out independently of operation instrument 400 and/or with operation instrument 400.
It is particularly preferred that the test system discretely carries out independently of operation instrument 400 and/or with operation instrument 400.ForThis purpose, analysis device 200 be preferably designed to using transmission control information 510 and independently of operation instrument 400 and/orWith operation instrument 400 discretely and/or disconnect ground and/or the implementation when data connection DVA is disconnected, terminates or interruptedOr continue to test.
This makes that for example control information 510 analysis device 200 can be transmitted to by operation instrument 400, to start testProgram, and then disconnect, terminate or interrupt analysis device 200 and operation instrument 400 between data connection DVA so thatWith analyzing 200 self-applying of device (self-actingly), carry out automatically and/or automatically and independently of operation instrument 400 and surveyExamination or can self-applying (self-actingly), automatically and/or automatically and independently of operation instrument 400 carry out test.CauseThis, when performing a test, user is moved away from analysis device 200 together with operation instrument 400 and/or operation instrument can be used400 for other purposes.
To carry out test, analysis device 200 is preferably applied to storage tube 100 and to prepare in storage tube 100, conveyAnd/or analysis sample P, or analyze device 200 and be designed for this purpose.Preferably, test is or can be by analysis device 200Control device 207 controlled.
To carry out test, analyzes device 200 and particularly preferably preferably receive control via operation instrument 400 in each situationInformation 510 processed and preferably calibration information 520.For this purpose, operation instrument 400 is preferably designed to transmission control information510 and preferably calibration information 520, and analyze device 200 and be designed to receive control information 510 and preferably calibration information520。
Using control information 510, the device and/or actuator of 207 control analyzer part 200 of control device make these dressesIt sets and/or actuator acts on storage tube 100 or control device 207 is designed for this purpose.
Actuator is especially pump controller 202, (several) temperature control equipment 204 and/or (valve) actuator 205.WithBy means of actuator, sample P can convey in the fluid system 103 of storage tube 100 and/or the temperature of sample P can be changed and/or sampleP can be mixed with reagent and/or be prepared and/or be fed into sensor device 113 finally sensor device 113 to be relied on to measureMeasurement result 713 corresponding to sample P.
Sample P is delivered to sensor device in a manner of specified by control information 510 preferably in storage tube 100113 and/or analysis device 200 be designed to preferably along with storage tube 100 complete this.
Valve 115A, 115B of storage tube 100 preferably opened wide in a manner of specified by control information 510 or closure and/Or analysis device 200 is designed to complete this preferably along with storage tube 100.
One or more temperature control equipments 204 of device 200 are analyzed preferably through control so that with by control information510 specified modes are designed to sample P and/or the progress temperature control of sensor device 113 and/or analysis device 200 excellentSelection of land completes this together with storage tube 100.
Based on control information 510 and the control system of calibration information 520 is based preferably on preferably as combined Fig. 1 and Fig. 2 to sayIt is bright to carry out, especially to carry out the foranalysis of nucleic acids for detecting nucleic acid sequence and/or the protein for detecting proteinAnalysis.Therefore, control information 510 preferably designed to especially including instruction and/or parameter control information 510, so as toCarry out the protein analysis for detecting the foranalysis of nucleic acids of nucleic acid sequence and/or for detecting protein.However, other analyses are alsoIt is feasible.
Control information 510 preferably include valve control information 510A, be used to activate one or more valve actuators 205 so as toThe valve for opening wide and/or being closed on storage tube 100.
Alternatively or additionally, control information 510 includes controlling information for controlling the pump controller of pump controller 202510B, pump controller 202 act on the pump installation 112 of storage tube 100 mechanically or otherwise to penetrate storage tube100 103 trandfer fluid of fluid system (especially sample P).
Alternatively or additionally, control information 510 includes that temperature control equipment controls information 510C, designated analysis deviceThe temperature or temperature curve or temperature quantitative curve of 200 one or more temperature control equipments 204 are directed to analysis device 200204 assigned temperature of one or more temperature control equipments or temperature curve or temperature quantitative curve, therefore can be to sample P or dressIt is contained in another substance in the fluid system 103 of storage tube 100 and carries out temperature control, especially to carry out PCR and/or miscellaneousIt hands over.
Alternatively or additionally, control information 510 includes the execution information 511 for executing test, especially for controllingMake the sequence of different actuators.Execution information 511 also can with control information 510 separate, can be stored in database 500 and/orAnalysis device 200 and/or operation instrument 400 can be transmitted to.
Execution information 511 especially comprising delay information 511A, the cyclical information 511B for repeating certain steps and/orFor defining the conditional information 511C of the condition (especially threshold value) for triggering further step or event.
Controlling information 510 can be in the form of controlling shelves.Control information 510 preferably comprises or is represented by command sequence,Especially in proper order or program mode (PM) defines the execution of test.Analysis device 200 preferably includes the explanation for controlling information 510Device.
Analysis device 200 and/or control device 207 preferably include memory 207A, store and/or temporarily control information510 or the information can be stored.Especially, it is provided that analysis device 200 receives control information 510 and optionally calibration information 520 and willThe information preservation is in memory 207A.This make control device 207 can independently of operation instrument 400 and/or with operation instrument400 discretely and/or disconnect ground control analyzer part 200 and/or analyze the actuator of device 200 to carry out or to continueThe test of sample P.
Control device 207 preferably controls and/or feedback controls and/or be designed to control and/or feedback control analysisThe device of device 200 is tested to carry out.
Control device 207 preferably includes actuator interface 207B, relies on actuator interface 207B, can control one or moreActuator.In particular, actuator interface 207B can to supply power to one or more actuators and/or can be for oneOr multiple actuators specify target value.This makes can be by actuator interface 207B and for one or more temperature control equipments204 specified target temperature values and/or target temperature quantitative curve or curve.Alternatively or additionally, it can control pump controller202。
Pump controller 202 preferably includes stepper motor as driving element, and actuator interface 207B preferably includes to correspond toStepping motor controller.Due to this combination, fluid exact way can convey in the fluid system 103 of storage tube 100 very much.In addition, valve can be started and/or supply power to by analyzing device 200 and/or control device 207 via actuator interface 207BThe one or more of actuator 205, so that valve 115A, 115B for being located on storage tube 100 can be opened wide and/or be closed.
Alternatively or additionally, analysis device 200 (especially control device 207) includes for from sensor device 113Read the read module 207C of measurement result 713.What read module 207C can be designed to make to measure in sensor device 113It 713 digitisation of measurement result and stores in the form of code or data set and/or transmits these results.At least with measurement resultDigitisation some cases in, read module 207C also can be positioned in storage tube 100 or sensor device 113, and/or readThe measurement result 713 by 113 digitisation of sensor device can be read in modulus block 207C.
Alternatively or additionally, it analyzes device 200 and/or control device 207 may include wrong mould wrong for identificationBlock 207D.In particular, error module 207D is designed to the mistake in execution of detection test.Alternatively or additionally, mistakeModule 207D is detectable and the mistake of record delimitation condition (such as temperature, inclination or fellow), and/or according to and/or considerError detection carrys out control analyzer part 200.
Analysis system 1, storage tube 100 and/or analysis device 200 be preferably designed to carry out proposed method and/orThis method is preferably relied on control information 510, considers control information 510 or controlled in a manner of specified by control information 510System.However, can also modify hereafter described in method and the present invention also can be used for test especially biological sample otherMethod and advantageous for other methods.
In the background content of method, based on fluid or liquid (especially blood, saliva from mankind or animal bodyOr urine) the sample P at least one analyte A usually first via connector 104A be introduced to receive cavity 104 in,To detect disease and/or pathogen, sample P can be pre-processed and (especially filtered).
Once having received sample P, receive cavity 104 and/or its connector 104A just especially with liquid is close and/or airtight sideFormula fluid closure.
Preferably, storage tube 100 then links together with sample P or is connected to analysis device 200, is especially inserted into or slides intoInto analysis device 200.
Method sequence (especially flowing and conveying, the mixing and fellow of fluid) system is by analysis device 200 or controlDevice 207, especially by correspondingly starting and actuating pump controller 202 or pump installation 112 and/or valve actuator 205 or valve115A, 115B are controlled.
During foranalysis of nucleic acids, the sample P of mixing and/or pretreated wanted volume is then excellent in mixing chamber 107Selection of land is fed into one or more reaction cavity 109A to 109C, particularly preferably extremely via the optional middle chamber 106A in upstream(respective) one of 106C and/or addition or the different reagents of dissolution or primer (dried reagent S4 to S6) in this case.
In reaction cavity 109A into 109C, amplified reaction or PCR are carried out to replicate/Amplification Analysis object A.This especially withBy means of assigned (preferably common) reaction temperature control device 204A and/or preferably for total overall reaction cavity 109A to 109CIt carries out simultaneously (that is, especially with same loop and/or temperature (curve/quantitative curve)).
During foranalysis of nucleic acids, label system especially directly generates and/or in (several) amplified reaction (in each situation)Period generates and/or is attached to analyte A and/or amplified production.This is especially by using corresponding (preferably biotinylation)Primer and reach.However, label also can individually or then (optionally also only in the sensor compartment of sensor device 113 and/orAfter hybridization) it generates and/or is bonded to analyte A and/or amplified production.In particular, label exists during protein analysisAnalyte A is only bonded after hybridizing with capture molecule to analyte A.
Label system especially is used to detect bond analyte A and/or amplified production.In particular, detectable label or can beThe label is identified in detection program, is illustrated as explained in greater detail below.
After implementation (several) amplified reaction, corresponding fluid volume and/or amplified production are especially specific via groupAnd/or independent middle chamber 106E, 106F or 106G (difference) and/or cavity 110 is controlled via optional (common) medium temperatureContinuously be channeled out reaction cavity 109A to 109C to sensor configuration (especially sensor device 113 and/or sensor everyBetween).
After sample P and/or analyte A and/or amplified production are fed into sensor device 113, analyte A and/Or amplified production is preferably by especially by sensor temperature control device 204C to sensor configuration or sensor device113 progress (active) temperature are controlled and (are especially heated) and hybridize with capture molecule.
When carrying out protein analysis, sample P or analyte A are preferably fed directly to sensor from mixing chamber 107Configuration or sensor device 113 and/or to be directed through (several) middle chamber 106A to 106G, (several) via bypass 114A anti-Cavity 109A to 109C and/or medium temperature is answered to control cavity 110.
Once sample P, analyte A and/or amplified production have hybridized and/or be bonded to capture molecule, just especially rely onThe label that preferably provides is detected in another way.
Hereinafter, one of detection particularly preferably variant (the clearly Electrochemical Detection of speech) is more fully described, but also may be usedCarry out other kinds of detection, such as optical detection, capacitance detecting or fellow.
After (respective) bond/hybridization, optional washing procedure and/or optional feed-in preferably occurs especially from storageDeposit the additional agents or liquid of cavity 108B to 108E.
Then and/or after washing procedure, it according to one of method preferred variants, is bonded to the analysis of capture moleculeThe detection of object A and/or amplified production.
If bond analyte A or amplified production especially still mark or are provided with mark without label during protein analysisLabel, then label is then preferably fed into sensor configuration or sensor compartment from storage cavity 108E.Optionally, then exist anotherOne washing procedure.
It is for the analyte A or amplified production of detection bond to capture molecule, reagent F4 and/or detector molecule is (specialIt is alkaline phosphatase/Streptavidin) preferably sensor device 113 is fed into from storage cavity 108D.
Within the meaning of the present invention, term " detector molecule ", which is preferably understood that, means specificity bond to (bond) pointThe label or label of analysis object A or amplified production and the molecule for therefore allowing it to detect.
In particular, detector molecule can be enzyme conjugate and/or immune conjugate, Deng specificity bond to label or markSign (especially biotin) and including for converting the report enzyme by matter.
In background content of the invention, detector molecule is preferably that (it has to biotin based on StreptavidinHigh-affinity) and/or alkaline phosphatase (non-reacted phosphate monoester can be converted to electrochemically active molecules and phosphate by it).
Preferably, using detection system, wherein label system is based on biotin and wherein detector molecule system is based on strepto- parentWith element/alkaline phosphatase.However, other detector molecules also can be used.
Reagent F4 or detector molecule can be bonded to bond analyte or amplified production, especially bond extremely bond analyteThe label of A or amplified production, particularly preferably bond to biotin labeling.
Optionally, then or be bonded in reagent F4 and/or detector molecule to analyte A and/or amplified production and/or markAfter label, preferably carry out (additional) washing procedure and/or flushing by fluid or reagent F3 or washing buffer, especially withJust it is not bonded reagent F4 and/or detector molecule from the removal of sensor device 113.
Preferably, by especially from the reagent S8 for being used to detect of storage cavity 106D and/or by matter finally preferablyTogether with fluid or reagent F2 (especially buffer) (it is suitable for by matter, particularly preferably for solubilising reagent S8 and/or by matter)It is fed into sensor configuration or sensor device 113, fluid or reagent system especially obtain from storage cavity 108B.
Preferably, use to aminocarbonyl phenyl phosphate (pAPP) as by matter.
It reacts and/or allows by selection of land pair of fine quality and/or with bond analyte A or amplified production and/or detector moleculeThese carry out electrochemical measurement.
Preferably, first or electroactive substance tie up in sensor device 113 by electrochemical measurement and/or oxidationRestore cycle detection.
Measurement preferably only carries out entire sensor array 113A and/or needle primary and/or for sensor device 113All sensors field 113B to the sensor array is especially while or parallel progress.In particular, bond analyte A or amplificationProduct ties up in single or common detection program and is detected, identified or measured contemporaneously or in parallel.
However, in principle, it also can be continuous or independent in sensor device 113 or in a plurality of sensor devices 113Ground measures a plurality of sample parts.
Test result or measurement result 713 preferably transport to analyzer part by arrangements of electric connection 203 (especially) fax200 or its control device 207, and correspondingly especially by display device 209 and/or the preparation of interface 210, analysis, assessment, storageIt deposits, show and/or exports.
After having been carried out test, storage tube 100 is disconnected and/or is released from or pop up with analysis device 200, andEspecially abandon.
The test method being outlined above or test result or measurement result by the measurement of another test method are relied on713 preferably transport to analyzer part 200 and/or its control device 207 by arrangements of electric connection 203 (especially) fax.MeasurementAs a result 713 systems are preferably transmitting to operate instrument 400 from or via analysis device 200, and prepare, divide by operation instrument 400Analysis, assessment, storage, display and/or output.
(several) measurement result 713 of sensor device 113 preferably from storage tube 100 be transmitted to analysis device 200 and/Or it is retrieved by analysis device 200 from storage tube 100 and/or sensor device 113.For this purpose, analysis system 1 is preferablyIt is designed to the sensor device 113 from storage tube 100, ties measurement from analysis device 200 and/or via analysis device 200Fruit 713 is transmitted to operation instrument 400.This is indicated in Fig. 4 by arrow 607, is corresponded to by analysis device 200 from storingThe result of 100 retrieval of cylinder.
In the one aspect that can also independently implement of the invention, (several) measurement result 713 (that is, especially withAnalyze 200 test sample P of device result) be preferably transmitting to without any previous evaluation operation instrument 400 orIt can be transmitted without any previous evaluation.This is indicated in Fig. 4 by arrow 608, is corresponded to from analysis device 200To the data transmission of operation instrument 400.
Transmission measurement result 713 realizes analysis device 200 without any previous evaluation in analysis device 200External assessments individual and/or that adjustment can be easy.
The transmission of measurement result 713 without any previous evaluation is also referred to alternatively as unprocessed measurement result713 transmission.This is interpreted as meaning, although can provide to handle in data transmission implementation such as transfer protocol, to solveError of transmission or fellow do not provide to explain measurement result 713 before being transmitted, that is, do not determine or establish the weight of measurement resultIf the property wanted and be applicable in, do not draw a conclusion to the property about sample P.In the present circumstances of biological sample P, this especially anticipatesMeaning does not assign measurement result 713 in there are Cucumber/analyte and/or concentrates in outside in analysis device 200And/or disease or fellow.
Operating instrument 400 after analysis device 200 and/or the reception measurement result 713 of storage tube 100, preferablyThe assessment of the measurement result 713 in operation instrument 400.In Fig. 4, by the instruction of arrow 609 by the assessment journey of operation instrument 400Sequence.
Measurement result 713 by operation instrument 400 assessment also can independently of analysis device 200 and/or with analysis device200 discretely and/or with disconnecting carry out.
As mentioned previously, operation instrument 400 can be special based on storage tube identifier 100C and/or device identifier 200CIt is to determine and/or retrieve assessment information 530 from database 500.Assessment information 530 is designed or is used to assess dduring testThe measurement result 713 of measurement.Measurement result 713 can be based on by operation instrument 400 or be assessed using the assessment information 530.OutIn this purpose, operates instrument 400 and be preferably designed to from the retrieval of analysis device 200 and/or receive measurement result 713.
In the one aspect that can also independently implement of the invention, the assessment of operation instrument 400 or it is designed to using commentingEstimate information 530 and discretely and/or with disconnecting assesses measurement knot independently of analysis device 200 and/or with analysis device 200Fruit 713.Analysis device 200 and the data connection DVA operated between instrument 400 can also break after having retrieved measurement result 713Connection, termination or interruption are opened, and assessment also can discretely and/or with disconnecting be carried out with analysis device 200.
In particular, assessment information 530 includes instruction (especially algorithm), to use 713 operation of measurement result or calculatingAnd to assign these measurement results 713 in physical variable, value or property.Therefore, measurement result 713 can be explained.
Assessment information 530 is preferably batch that is individual, unique and/or being specific to specific storage tube 100 or storage tube 100And/or the combination of particular analysis device 200 and/or specific storage tube 100 and analysis device 200.Alternatively or additionally, it assessesInformation 530 is individual, unique and/or is specific to the one/operation instrument 400, especially operates the operating system of instrument 400.
Assessment information 530 particularly preferably depends on the particular sensor means 113 of respective storage tube 100 and may be specialIn the spy that the storage tube and/or usable a kind of storage tube or a collection of storage tube of certain types of storage tube or particular batch are carried outFixed test or assessment.
Measurement result 713 can be based on by operation instrument 400 or be assessed using the assessment information 530.
Assessment information 530 preferably includes (field) assignment information 531, in the sensor with a plurality of sensors field 113BFunction and/or property are assigned in the measurement result 713 for corresponding to respective sensors field 113B in the case where device 113.
Alternatively or additionally, assessment information 530 includes assigning certain properties of sample P in the solution of measurement result 713Release information 532.This explains that information can be threshold value, or explains that information 532 includes threshold value or fellow.
Preferably, it explains that information 532 can be used, be related to respective sensors field 113B and/or be related to the measurement corresponding to itAs a result 713, and therefore explain that information 532 includes (field) assignment information 531 or anti-.
(field) assignment information 531 particularly preferably depends on the particular sensor means 113 of respective storage tube 100 and mayThe particular analysis for being specific to certain types of storage tube and/or a kind of storage tube can be used to carry out.Alternatively or additionally, equallyAlso it is suitable for explaining information 532.
Especially when can be used identical storage tube 100 to carry out different tests, difference can be provided for identical storage tube 100Information 510 and/or calibration information 520 and/or assessment information 530 are controlled, and information corresponds respectively to one of feasible testPerson.
Assessment information 530 preferably includes that (it is equal preferably in value, number, code or the shape of fellow by measurement result 713Formula) it assigns in a physical variable.Therefore, measurement result 713 can be explained.
(field) assignment information 531 is preferably designed to refer to each of measurement result 713 from respective sensors field 113BIt sends in the property or sensor type of respective sensors field 113B.
If referred at the beginning, assessment information 530 preferably includes to preferably form the finger of algorithm and/or plug-in unit or moduleIt enables.This assessment information 530 can formation operation instrument 400 evaluation module 440 all or part.For this purpose, assessment letterCease 530 systems as define evaluation module 440 and/or operate instrument 400 behavior component or it is module integrated in operation instrument 400In.
Operation instrument 400 is preferably implemented by the processor or controller interpretative order for using the operation instrument 400Assess information 530.Instruction be especially for operation instrument 400 on execute source code, prelist decoding or machine code.
Assessment information 510 is preferably specific to a certain group of operation instrument 400, is especially specific to a certain operating system or oneGroup job system.
Depending on operate for identification instrument 400 or especially with identical operation system operation instrument 400 group,The operation instrument identifier 400C of classification or type, it is possible to provide, enable and/or retrieve various forms of identical or different assessments lettersBreath 510.In particular, database 500 sends back the assessment information 510 of this type when transmission operates instrument identifier 400CIt, can be by the processing of operation instrument 400, compiling, use and/or execution to operation instrument 400.
Therefore, analysis system 1 (especially database 500) preferably includes different item assessment information 530 or is designed to produceRaw and/or offer different item assesses information 530, and different item assessment information 530 generates on different operation instrument 400 or realize phaseSame or similar functionality.However, assessment information 530 is preferably specific to storage tube 100 or a collection of storage tube 100.
Therefore, different item assessment information 530 is preferably through providing and/or can be directed to different storage tubes 100 or different batchesStorage tube 100 retrieve, and these different items assessment information 530 is respectively provided and/or can respectively be directed to different operation instrument400 are retrieved with different editions.
Operation instrument 400 preferably export or be designed to by output device 410 export assessment result 740, be byIt is determined and (is especially calculated) by using assessment 530 assessment of the measurement result 713 of information.For this purpose, operation instrument 400 can be usedFigure or otherwise the display assessment result 740 (especially by screen or display 411).Alternatively or additionally, it graspsMake instrument 400 and sends or be designed to send assessment result 740 to database 500.
Operation instrument 400 is preferably designed to for the control information 510 for being used to receive or pop up storage tube 100 being transmitted toAnalyze device 200.Alternatively or additionally, operation instrument 400 is designed to transmit the control information 510 for being used to start testTo analysis device 200.Alternatively or additionally, operation instrument 400 is designed to from the retrieval of analysis device 200 and/or receives surveyMeasure result 713.
Operation instrument 400 is preferably designed to receive and/or show the mode of operation of analysis device 200.
In particular, operation instrument 400 includes the graphical user interface being shown on screen or display 411.The figureUser's Interface preferably includes graphically to analyze the possibility control piece of device 200 and/or the interface of state.Alternatively or volumeOther places, User's Interface are designed to control with database 500 and/or interact with device 200 is analyzed.For this purpose, it graspsMaking instrument 400 can itself be engineered so that especially to be touch-sensitive via touch sensitive screen or display 411.Alternatively or additionally, soAnd User's Interface can also be controlled via Trackpad 422, microphone 423, keyboard 424 or other a certain input units 420.
In one aspect of the invention, analysis system 1 includes supporting a plurality of storage tubes of identical or different test100.Therefore, a plurality of different types of storage tubes and/or analysis system 1 that can exist for carrying out different tests may include orSupport the storage tube of these types.These storage tubes 100 are preferably inserted into same analysis device 200 and/or preferably realRow can carry out the test for using storage tube 100 by same analysis device 200.
In another aspect, proposed analysis system 1 includes a plurality of analysis devices 200.Preferably, device 200 is analyzedSame operation instrument 400 can be each coupled to.Therefore, same operation instrument 400 can be connected to different analysis devices 200, dataConnection DVA is preferably connected to or is established to only one of analysis device 200 in any one time.Alternatively, however, it is identicalOperation instrument 400 can also be connected to a plurality of analysis devices 200 simultaneously.In this case, operation instrument 400 preferably assists choosingAnalysis device 200 is selected for configuring and/or controlling.In particular, analysis device 200 can be filled by operation instrument 400 via inputIt sets 420 to be selected, so that then (only) analysis device 200 is selected in control.
Analysis system 1 may include or support a plurality of operation instruments 400.In particular, a plurality of operation instruments 400 can replaceGround but it is preferably different when be coupled to same analysis device 200.By making analysis device 200 be coupled to operation instrument 400, preferablyGround establishes analysis device 200 and operates the data connection DVA between instrument 400, so that control information 510 can be transmitted to analyzerPart 200 and/or result can be transmitted to operation instrument 400.
Database 500 is preferably included for using different storage tubes 100 and/or different analysis devices 200 to carry out testA plurality of different items control information 510.Control information 510 is also formed as multiple portions.In particular, control information 510 can wrapIt includes the part for being specific to storage tube 100 and is specific to the part of analysis device 200.
Analysis device 200 is preferably by the calibration information that can be formed the part of control information 510 or can be provided separately520 are calibrated and/or are configured.For this purpose, calibration information 520 can be determined by operation instrument 400, retrieve and/or be passedTransport to analysis device 200.
In an example, fluid sensor calibration information 521 is provided, influence fluid sensor 206A setting and/Or assessment.Fluid sensor calibration information 521 preferably depends on test to be carried out.
In the another aspect that can also independently implement of the invention, computer program product is provided comprising for realThe program code devices of row proposed method.Computer program product be especially especially with intelligent telephone application program orThe form of fellow is stored in the instruction on storage medium, is arranged to determine and/or receive storage tube identifier 100C.It replacesFor ground or extraly, which is designed to storage tube identifier 100C is transmitted to database 500 and then from database 500Receive control information 510.Alternatively or additionally, which is designed to that the transmission of information 510 will be controlled or transfers to analyzerPart 200.Alternatively or additionally, the instruction be designed to especially with retrieval and/or received assessment information 530 reception,Assessment and/or explanation measurement result 713.
Assessment of the measurement result 713 preferably includes to assign corresponding to the measurement result 713 of particular sensor field 113B in eachFrom the function of sensors field 113B.This can by use different appraisal procedures, threshold value or fellow for different sensors field113B and reach.
The sensors field 113B of identical type can be assessed together.In this case, it is preferable that tested for suitable large deviationThe measurement result 713 of sensors field 113B corresponding to identical type rejects the sensors field 113B's relative to identical typeOther measurement results 713 have the measurement result 713 of suitable large deviation, and only assess the class of the sensors field 113B of identical typeLike measurement result 713.
During assessment, it may be determined that the measurement result 713 of the sensors field 113B of identical type.Alternatively or additionally,Measurement result 713 (such as its average value) can be jointly or with calculation with threshold value or with a plurality of threshold value comparisons or with a certainOther modes assessment.In this case, one or more threshold values can for value or (alternatively or additionally) specified quantitative curve orCurve series (curve progression), specified gradient, its maximum value or fellow.
By assessment of the measurement result 713, assessment result 740 is preferably directly generated, the object of sample P is preferably corresponded toReason value, parameter or property.For example, assessment result 740 indicates certain DNA sequence dnas and/or RNA sequence and/or protein (especiallyAntigen and/or antibody) presence.
Alternatively or additionally, however, assessment result 740 also may be or include from DNA sequence dna and/or RNA sequence and/orThe presence of protein (especially antigen and/or antibody) is derived to be explained, (all especially with regard to a certain disease and/or pathogenSuch as virus, bacterium or fellow) with the presence or absence of in sample P or the information of its possibility.
Assessment result 740 is preferably exported by the output device 410 of operation instrument 400, or can be by output device 410Output (is especially shown).
If detecting disease and/or pathogen, propose: operation instrument 400 exports or sends automatically warning and/or newsBreath.
Preferably achieve measurement result 713 and/or assessment result 740.It is particularly preferred that these results are saved or temporarilyIt is stored in operation instrument 400.Alternatively or additionally, these results are saved and/or are archived in database 500, especiallyIt is in the result memory 550 of database 500.For this purpose, assessment result 740 can transmit 610 from operation via dataInstrument 400 is transmitted to database 500.
Achieving in database 500 can be relative to the measurement knot in aborning assessment information 740 and/or retrieval or receptionFruit 713 temporarily deviates.This especially ties up between database 500 and operation instrument 400 that there is no in the case where data connection DVDThe case where carrying out test or assessment.In this case, once reduction or data connection DVD, measurement result 713 can be re-establishedAnd/or assessment result 740 temporarily offset manner and/or can be transmitted to database 500 in later point.
Control information 510 and/or calibration information 520 and/or assessment information 530 can with analysis device 200 discretely, disconnectIt connects ground and/or is independently retrieved from database 500.For this purpose, the data between storage tube 100 and operation instrument 400DVB is connected preferably for example to read in bar code 124 by operation instrument 400 and determine that storage tube identifier 100C comes by assessingIt uses.This disconnects, terminates or interrupts Shi Yike in the data connection DVA analyzed between device 200 and operation instrument 400Row.
In addition, operation instrument 400 also can independently of storage tube 100 and/or analysis device 200, with storage tube 100 and/orAnalysis device 200 disconnects ground and/or discretely retrieves control information 510, calibration information 520 from database 500 and/or commentEstimate information 530.Thus, for example operation instrument 400 can first determine that, read or receive storage tube identifier 100C.From database500 retrievals then can be carried out also independently of storage tube 100 and/or analysis device 200.For this purpose, it especially only needs to operateData connection DVD between instrument 400 and database 500.Retrieved data can be temporarily stored in memory 450.
Analysis device 200 determines or reads storage tube and identifies preferably before carrying out test using specific storage tube 100It accords with 100C and sends it to operation instrument 400, even if operation instrument 400 has previously been retrieved or received control information 510, calibratedInformation 520 and/or assessment information 530.Then, operation instrument 400 is transmitted to from analysis device 200 before test has startedStorage tube identifier 100C can be checked to determine whether to provide and correspond to storage tube 100 and/or storage tube by operation instrument 400The control information 510 of identifier 100C, calibration information 520 and/or assessment information 530, Deng especially having stored or temporarily store upIt is stored in memory 450.
If operation instrument 400 identify corresponded to the control information 510 of storage tube 100 or storage tube identifier 100C with/Or calibration information 520, then it can transmit this information to analysis device 200 and can start to use to be inserted into and analyze in device 200The test of storage tube 100.
Alternatively, information 510 and/or calibration information 520 are controlled needed for retrieving from database 500.
In one of present invention advantageous development, analysis system 1 includes a plurality of differences for carrying out preferred different testsStorage tube 100, difference control information 510 and assessment information 530 correspond to different tests.
Especially when can be used identical storage tube 100 to carry out different tests, can be provided for identical storage tube 100,Select, may be selected, retrieve, can retrieve, using and/or can be used different control information 510 and/or assessment information 530, and controlInformation 510 corresponds to the one of feasible test in each situation.
In the another aspect that can also independently implement of the invention, computer program product is provided comprising for realThe program code devices of row proposed method.This computer program product is especially especially with intelligent telephone application programOr the form of fellow is stored in the instruction on storage medium.
Instruction is preferably arranged to control operation instrument 400, and/or determines and/or receive storage tube identifier 100C.
Alternatively or additionally, instruction is arranged to control operation instrument 400, and storage tube identifier 100C is transmitted to numberControl information 510 is received from database 500 according to library 500, and then.
Alternatively or additionally, instruction is designed to control operation instrument 400 and/or is designed to that information 510 will be controlledTransmit or transfer to analysis device 200.
Alternatively or additionally, instruction is designed to control operation instrument 400, and/or is designed to especially with inspectionRope and/or received assessment information 530 receive, assess and/or explain measurement result 713.
In general, analysis device 200, storage tube 100 or especially sensor device 113 can rely on specific bond, it is specialIt is not by capture molecule and/or by the electrification executed preferably on storage tube 100 and/or in sensor device 113It learns detection (such as redox cycle or fellow) measurement, detection or identifies one or more analyte A.Preferably, it capturesMolecule is configured or is fixed on an array of sensors or on the sensors field or electrode of sensor device 113.In particular, can be realIt is existing or realize for detecting or the immunoassay of identification of protein or protein analysis and/or for detecting or identifying nucleic acid sequenceKernel analysis.
Alternatively or additionally, it is preferable in analysis device 200 and/or storage tube 100 or by analysis device 200And/or storage tube 100 uses or executes the measurement without specific bond and/or without Electrochemical Detection.These measurements may include opticsMeasurement, impedance measurement, capacitance measurement, spectral measurement, mass-spectrometer measurement or fellow.For this purpose, device 200 or storing are analyzedCylinder 100 may include optical spectrometer and/or allow to be handled or the optical measurement of unprocessed sample P.Therefore, it can measure, examineOther or further analyte A, chemical combination of survey or identification (for example) storage tube 100 or the sample P in any other sample carrierObject, material property or fellow.These substitutions or additional measurement can be similar to the mode of description or use in different ways orProcessing and/or assessment.
In particular, be also related to can be independently or with any combination, also combine above or in invention claim by the present inventionAny one for the following aspect that any aspect is realized described in book:
1. a kind of analysis system 1 is used to test especially biological sample P,
The analysis system 1 includes the storage tube 100 for receiving the sample P, and
The analysis system 1 includes for receiving the storage tube 100 and then carrying out test using the receiving storage tube 100Device 200 is analyzed,
It is characterized in that
The analysis system 1 includes operation instrument 400, can preferably be divided relative to data connection and the analysis device 200From and/or be wirelessly coupled to the analysis device 200,
The operation instrument 400 be designed to determine or receive correspond to the storage tube 100 storage tube identifier 100C andUsing this storage tube identifier 100C, from the retrieval of database 500 for carrying out the control information 510 of the test and/or by the controlInformation 510 processed is transmitted to the analysis device 200；And/or
The operation instrument 400 is designed to be used to carry out the control information for the test supported by the storage tube 100510 are transmitted to the analysis device 200, and the analysis device 200 be designed to independently of the operation instrument 400 and/or with the behaviourMake instrument 400 and is used separately the transmission control implementation of information 510 test；And/or
The analysis device 200 is designed to receive control information 510 from the operation instrument 400, uses the control information510 control the test of the sample P in the storage tube 100 and will be in the test phase without any previous evaluationBetween the measurement result 713 that measures be transmitted to the operation instrument 400；And/or
The operation instrument 400 be designed to determine or receive correspond to the storage tube 100 storage tube identifier 100C andUsing storage tube identifier 100C, from the retrieval of database 500 for assessing the measurement result 713 measured during the testInformation 530 is assessed, and is used separately the assessment information 530 independently of the analysis device 200 and/or with the analysis device 200Assess these measurement results 713.
2. 1 analysis system as in terms of, wherein the storage tube 100 includes memory device 100D, it is preferable to especiallyBy the analysis device 200 electronically and/or preferably by the camera 421 of the operation instrument 400 optically from the memoryDevice 100D reads storage tube identifier 100C, which is preferably designed to examine automatically from the database 500Rope be used for control the analysis device 200 so as to carry out by the storage tube 100 support the test the control information 510 and/Or for by the storage tube identifier 100C for reading the storage tube 100 or after having read storage tube identifier 100CAssess the analysis information 530 of the measurement result 713 by the measurements determination.
3. 1 or 2 analysis system as in terms of, wherein the control information 510 and/or the assessment information 530 include preferablyInstruction and/or these instructions in the form of algorithm are formed can be real by the analysis device 200 and/or the operation instrument 400The module applied, therefore the analysis device 200 and/or the behavior of the operation instrument 400 can be changed.
4. wherein the analysis device 200 is designed to believe using the control such as the analysis system of any one of aforementioned aspectsBreath 510 controls the device of the analysis device 200
The sample P is made to be delivered to sensor in the storage tube 100 in a manner of specified by the control information 510Device 113, and/or
The valve 115 of the storage tube 100 is made to open wide or be closed in a manner of specified by the control information 510, and/or
Make one or more temperature control equipments 204 of the analysis device 200 through control so as to believe by the controlThe specified mode of breath 510 carries out temperature control to the sample P and/or sensor device 113.
5. wherein the analysis device 200 includes: such as the analysis system of any one of aforementioned aspects
Receiver 210A is used for from the preferably wireless receiving of the operation instrument 400 control information 510, and/or
Memory 207A is used to store the control information 510, and/or
Control device 207 is used to control and/or feedback controls the device of the analysis device 200 to carry out the surveyExamination, and/or
Attachment device 203, is used to establish electronics with the sensor device 113 of the storage tube 100 and connect, and/or
Read module 207C is used for from the sensor device 113 of the storage tube 100 reading measurement result 713, and/Or
Transmitter 210B is used to the measurement result 713 read from the sensor device 113 being transmitted to the operation instrumentDevice.
6. wherein the operation instrument 400 includes evaluation module 440, warp such as the analysis system of any one of aforementioned aspectsDesign is preferably to assess the survey read from the sensor device 113 by the assessment information 530 retrieved from the database 500Measure result 713.
7. such as the analysis system of any one of aforementioned aspects, wherein the assessment information 530 includes explaining information 532, willThe appointment of these measurement results 713 makes that these measurement results 713 can be explained in physical variable.
8. wherein the sensor device 113 includes a plurality of sensors fields such as the analysis system of any one of aforementioned aspects113B and the assessment information 530 include assignment information 531, are used to tie from each measurement of these respective sensors field 113BFruit 713 is assigned in the property or sensor type of these respective sensors field 113B.
9. such as the analysis system of any one of aforementioned aspects, wherein the operation instrument 400 include output device 410 (preferablyGround display device, especially display 411) and be designed to output by use the assessment information 530 assessment these measurement tieThe assessment result 740 that fruit 713 determines and (especially calculates).
10. wherein the operation instrument 400 is designed to such as the analysis system of any one of aforementioned aspects
The control information 510 for being used to receive or pop up the storage tube 100 is transmitted to the analysis device 200, and/or
The control information 510 for being used to start the test is transmitted to the analysis device 200, and/or
Measurement result 713 is retrieved and/or received from the analysis device 200, and/or
Assessment result 740 is sent to database 500.
11. wherein the operation instrument 400 includes that input unit 420 is (special such as the analysis system of any one of aforementioned aspectsIt is touch sensitive screen), which can trigger order and/or information is transmitted to the analysis device 200；And/or
Wherein the operation instrument 400 and the analysis device 200 include respectively wireless data interface 430,210, Deng through settingMeter is preferably so that with jointly establishing exclusive data connection between the operation instrument 400 and the analysis device 200 as the behaviourMake instrument 400 and the analysis device 200 in space close to that at this point, the data connection (DVA) therebetween is established and excellent automaticallySelection of land is shown by the operation instrument 400.
12. such as the analysis system of any one of aforementioned aspects, wherein the operation instrument 400 includes being used for independently of one anotherThe distinct interface 430 that data connection (DVA, DVD) is established with the analysis device 200 and the database 500, as the operation instrumentThe analysis device 200 of 400 peripheral devices is designed to uniquely communicate with or via the operation instrument 400.
13. wherein the analysis system 1 includes for carrying out preferred different surveys such as the analysis system of any one of aforementioned aspectsA plurality of different storage tubes 100 of examination, difference control information 510 and assessment information 530 correspond to different tests.
14. a kind of test the especially method of biological sample P by analysis system 1,
The analysis system 1 includes the storage tube 100 for receiving the sample P, which includes for measuring sampleThe sensor device 113 of particular measurement result and fluid system for the sample P to be delivered to the sensor device 113,
The analysis system 1 includes for receiving the storage tube 100 and then carrying out the test using the receiving storage tube 100Analysis device 200,
It is characterized in that
The analysis system 1 includes operation instrument 400, can preferably be divided relative to data connection and the analysis device 200From and/or be wirelessly coupled to the analysis device 200,
The operation instrument 400 determines or receives the storage tube identifier 100C for corresponding to the storage tube 100 and uses the storageObject cylinder identifier 100C, from the retrieval of database 500 for carrying out the control information 510 of the test and/or by the control information 510It is transmitted to the analysis device 200；And/or
The operation instrument 400 transmits the control information 510 for being used to carry out the test supported by the storage tube 100To the analysis device 200, and the analysis device 200 independently of the operation instrument 400 and/or with the operation instrument 400 discretelyThe test is carried out using transmission control information 510；And/or
The analysis device 200 receives control information 510 from the operation instrument 400, should using the control information 510 controlThe test of the sample P in storage tube 100 and the survey that will be measured during the test without any previous evaluationAmount result 713 is transmitted to the operation instrument 400；And/or
The operation instrument 400 determines or receives the storage tube identifier 100C for corresponding to the storage tube 100 and uses the storageObject cylinder identifier 100C, from the retrieval of database 500 for assessing the assessment information of the measurement result 713 measured during the test530, and independently of the analysis device 200 and/or with the analysis device 200 be used separately the assessment information 530 assessment theseMeasurement result 713.
15. a kind of computer program product comprising lead to the side for carrying out method according to claim 14 when being executedThe program code devices of method step.
Individual aspects of the invention and feature and individual method steps and/or method variant can be implemented independently of one another, butAlso with it is any to be combined and/or sequence implement.
[symbol description]
1 analysis system
100 storage tubes
100C storage tube identifier
100D memory device
101 main bodys
102 the covers
103 fluid systems
104 receive cavity
104A connector
104B import
The outlet 104C
104D intermediate connector
105 metering cavities
106A-G middle chamber
107 mixing chambers
108A-E stores cavity
109 reaction cavities
The first reaction cavity of 109A
The second reaction cavity of 109B
109C third reaction cavity
110 medium temperatures control cavity
111 collection chambers
112 pump installations
113 sensor devices
113A sensor array
113B sensors field
114 channels
114A bypass
The initial closure valve of 115A
The initial full-opening valve of 115B
116 Sensor sections
124 bar codes
200 analysis devices
200C device identifier
201 tanks
202 pump controllers
203 attachment devices
203A contact element
204A reaction temperature control device
204B medium temperature control device
204C sensor temperature control device
205A is used for (valve) actuator of 115A
205B is used for (valve) actuator of 115B
206A fluid sensor
206B other sensors
206C temperature sensor
206D inclination sensor
206E acceleration transducer
206F humidity sensor
206G position sensor
206H storing cylinder sensor
207 control devices
207A memory
207B actuator interface
207C read module
207D error module
208 input units
209 display devices
210 interfaces
210A receiver
210B transmitter
211 power supplys
211A connector
212 shells
The inner space 212A
213 openings
214 gas-pressurized power supply units
214A connecting element
400 operation instruments
400C operates instrument identifier
410 output devices
411 displays
412 loudspeakers
420 input units
421 cameras
422 Trackpads
423 microphones
424 keyboards
430 interfaces
431 analysis device interfaces
432 database interfaces
440 evaluation modules
450 memories
500 databases
510 control information
510A valve controls information
510B pump controller controls information
510C temperature control equipment controls information
511 execution informations
511A postpones information
511B cyclical information
511C conditional information
520 calibration informations
521 fluid sensor calibration informations
524 calibration informations (inclination sensor)
525 threshold values (inclination sensor)
526 start threshold value (inclination sensor)
527 outage thresholds (inclination sensor)
528 calibration informations (sensor configuration)
530 assessment information
531 (field) assignment informations
532 explain information
550 result memories
601 data transmit storage tube-analysis device
602 sub-data transmission parser parts-operation instrument
603 data transfer operation instruments-database
604 data transfer rate libraries-operation instrument
605 data transfer operation instruments-analysis device
606 test programs
607 result retrieval storage tubes-analysis device
608 sub-data transmission parser parts-operation instrument
609 appraisal procedures
610 data transfer operation instruments-database
Measurement result of the 706A from fluid sensor
Measurement result of the 706B from another sensor
Measurement result of the 706C from temperature sensor
Measurement result of the 706D from inclination sensor
706E carrys out the measurement result of acceleration sensor
Measurement result of the 706F from humidity sensor
Measurement result of the 706G from position sensor
Measurement result of the 706H from storing cylinder sensor
713 measurement results from sensor device
740 assessment results
A analyte
DVA data connection analyzes device-operation instrument
DVB data connection storage tube-operation instrument
DVC data connection storage tube-analysis device
DVD data connection database-operation instrument
F (1-5) liquid reagent
P sample
N (data) network
S (1-10) dried reagent