Utilize the selective skin treatment of the equivalent intense pulsed light device of laserInvention field
This application involves the light processing being applied on human skin tissue, more particularly in intense pulsed light device it is sharpWith the light processing of selective bandpass optical filter.
Background of invention
Light ray radiation is the known way for skin disease disorder processing.In order to obtain clinical effectiveness in skin, irradiateLuminous energy be preferably absorbed in skin.
Light absorption in skin is dominated by three kinds of endogenous chromophories: water, melanin and hemoglobin.Optical wavelength or wavelengthCorrectly matching between spectrum and target chromophore may cause optical energy absorption, may be by one or more photo-thermal, lightChemistry or photomechanical effect bring clinical effectiveness.When luminous energy irradiates on the skin, light scattering effect may influence light and wearThe depth organized thoroughly.Since the concentration of collagenous fibres in corium is higher, this effect (if any) is in the dermis than in tableIt is more dominant in skin.In general, the wavelength of scattered quantum and light is inversely proportional until the mid infrared region of luminous energy.As Anderson and" selective light thermal decomposition: the carrying out accurate microsurgery by the selective absorbing of impulse radiation " of Parrish is mentionedAnd, Science, April 29 nineteen eighty-three；220 (4596): 524-7, as described above, by selecting wavelength appropriate to appropriateChromophore, may be implemented selective laser treatment, by apply energy pulse be shorter than or equal to target chromophore thermal relaxationTime, and the energy by being higher than threshold value to destination organization delivering.Different various laser and intense pulsed light (IPL) device makeThe optical treatment of wide scope is provided with these principles for skin disease.
Polychrome of the IPL device transmitting in about 400nm to the about spectral region of Isosorbide-5-Nitrae 00nm, incoherent and non-collimated light,And usually with the delivering of various pulse durations.Therefore, the selectivity of IPL is lower, because can aim in the range notSame chromophore.A kind of selection for improving the selectivity for the luminous energy that IPL is generated is using filter.In the transmitting light of IPL deviceThe lower end of spectrum uses cut-off filter, and uses incision filter in the upper end of emission spectrum.This filter can improveProcessing selectivity reduces parasitic wavelength, this may make patient be in danger, such as ultraviolet light or increased whole heating,Such as there are infrared ingredients in the light emitted.Common medical IPL cut-off filter include 550,560,570,590,615,645,695,755 and 780nm filter.Cut-off filter and incision filter can be used together to create so-called bandBandpass filter.
Bandpass filter is provided by some suppliers (for example, Alma Lasers etc.), for example, providingThe narrow spectrum processing based on IPL within the scope of 500nm-600nm, for medical needle to the vascular lesion of larger blood vessel.In 550nm-Another narrow-band pass filter is provided in the range of 600nm and is used for skin regeneration.One of the problem of this filter, is, is filteringIn photoreduction process, they also remove the partial optical energy generated by light source, and light source is IPL light source.Therefore, meet to pass throughAbove-mentioned threshold energy requires to generate clinical effectiveness, can only remove limited amount spectrum.
In laser domain, vascular lesion is treated by aiming at the intravascular chromophore of oxyhemoglobin, oxygenated blood is redAlbumen has optical absorption peak at 418nm, 542nm and 577nm.The most common blood vessel laser is KTP, 532nm, pulsed dyeLaser (PDL) 585nm-595nm, alexandrite 755nm, diode laser 940-980nm and Nd:YAG 532 or 1,064nm.PDL is considered as " main force " blood vessel laser.
As described above, IPL light source can be used for the treatment of vascular lesion, using including at least one in these absorption peaksA filter and removal may cause the destructive UV wavelength and/or infrared wavelength of subsidiary thermal damage.Two companies,Lumenis and Palomar provides this two band filter.For example, in blood vessel two band filter, shorter wavelength be used for compared withSmall superficial vein, and longer wavelength is used for biggish deeper blood vessel.
Pigment lesions are also by laser therapy, and by using laser, such as KTP (532nm), ruby (694nm) is emerald greenJewel (755nm) etc., using the melanin in melanosome as target chromophore, using the various pulse durations, from millisecondGrade start to picosecond.IPL can also be used for some pigmented lesions, such as pigmentation disease or solar lentigines mole.Equally, pass through choosingThe filter for generating appropriate spectral energy is selected, as long as the sufficiently wide energy density for making sufficient amount of spectrum reaches destination organization, IPLThe device of driving can be used for treating at least some pigmented lesions.However, spectrum is wider, different chromophories can be aimed at simultaneouslyAnd selectivity can be reduced.In addition, in order to avoid cicatrization or the side effect of decoloration, it may be necessary to which short pulse targets to limitThe area or volume of any fuel factor in tissue.These short pulses can be within nanosecond or smaller range, and IPL is only in millisecondPulse is provided in range.
Various types of dermopathic flexibilities are treated on various types of skins using single source IPL in a deviceStill it haves a great attraction.Therefore, it is necessary to a kind of more advanced systems to provide the processing based on IPL, have with higherSelective or higher absorbance is imitated, its equivalent known laser wavelength designed for simulation is similar to.
Summary of the invention
In one aspect, a kind of device of the cosmetic treatments of the vascular lesion on skin histology, with operation wavelengthFor the laser equivalent of 532nm, comprising: the source intense pulsed light (IPL), the source IPL can be activated；It further comprises bandBandpass filter, when activating, the bandpass filter substantially stop from the source IPL sending substantially in addition to a wavelengthAll light of range；When activating, the bandpass filter allows to come from the source IPL within the scope of about 525nm to about 585nmLight transmission；The IPL with the bandpass filter provides the beauty with the laser equivalent that operation wavelength is 532nmProcessing.
On the other hand, a kind of cosmetic treatment method on body vessel region with 532nm laser equivalent is provided, is wrappedIt includes: the source intense pulsed light (IPL) is provided；Bandpass filter is inserted between the source IPL and the body vessel region；DescribedThe type of bandpass filter substantially passes through light in the range of about 525nm to about 585nm；The method further comprisesActivate the source IPL；The optical filtering being radiated on blood vessel body part provides the cosmetic treatments with 532nm laser equivalent.
On the other hand, a kind of beauty method providing light processing to skin histology includes providing the source intense pulsed light (IPL)；Bandpass filter is inserted between the source IPL and body vessel region；The bandpass filter is by about 525nm to aboutLight within the scope of 585nm；The method further includes activating the source IPL and applying it to the skin histology,In the optical filtering that is radiated on the skin histology provide and the processing of 532nm laser equivalent.
On the other hand, a kind of bandpass filter, it is described with the 532nm laser equivalent of irradiation on skin tissuesBandpass filter be configured to make through the light of the filter substantially in 525nm to 585nm range.
Further, a kind of beauty method providing light processing to skin histology includes providing intense pulsed light(IPL) the step of source；Bandpass filter is inserted between the source IPL and the skin histology；The bandpass filter makesLight in selected wave-length coverage passes through, and mean absorption coefficient is equal to the mean absorption coefficient of selected laser light source；The sideMethod further comprises the activation source IPL and applies it on the skin histology, wherein being radiated at the filter on the skin histologyLight provides the processing equivalent with selected laser light source.
On the other hand, the beauty in the source the equivalent intense pulsed light of the treatment effect for the laser light source for providing and selecting (IPL)Method comprising for the laser light source of selected specific wavelength, determine the mean absorption coefficient of specific wavelength in skin histology；And select the bandpass filter in skin histology with substantially equivalent mean absorption coefficient.The skin histologyIt can be one of following or a variety of: blood absorption and melanin absorption.
On the other hand, the source IPL further includes main part comprising the source IPL and in main partOpening to receive one or more bandpass filters, and the wherein described one or more bandpass filters are from describedThe source IPL passes through the light of different range to the filter of skin histology.One or more bandpass filters may be atOne or more of lower range: 560-690nm；675-900nm；700-800nm；725-775nm；940-980nm.
In one aspect, a kind of selection has the IPL light source of bandpass filter for providing the cosmetic treatments of skin histologyMethod, the bandpass filter is equivalent to the laser light source of specified wavelength, the described method comprises the following steps: selection is specifiedThe laser light source of wavelength；Activate the laser light source；Laser light source is guided to target；Measure the laser selected in the targetMean absorption coefficient；Store the coefficient of measurement；Select bandpass filter；The activation IPL light source；It measures in the targetThe mean absorption coefficient of the bandpass filter of selection；By the storage of the measurement coefficient of the bandpass filter and selected laser light sourceMeasurement coefficient be compared；If the measurement coefficient matches substantially, it is determined that selected laser light source and have instituteThe IPL light source of the bandpass filter of selection is equivalent.The target can be skin histology.
In one aspect, a kind of selection has the IPL light source of bandpass filter for providing the cosmetic treatments of skin histologyMethod, the bandpass filter is equivalent to the laser light source of specified wavelength, the described method comprises the following steps: selection is specifiedThe laser light source of wavelength；Activate the laser light source；The laser light source is guided to target；Selected laser is measured in the meshAverage depth of penetration in mark；The storage penetration depth；Select bandpass filter；The activation IPL light source；Measurement instituteState the average depth of penetration of bandpass filter selected in target；By the measurement average penetration rate of the bandpass filter and instituteThe measurement average penetration rate of the storage of the laser light source of selection is compared；If the average depth of penetration of measurement matches substantially,Then determine that selected laser light source and the IPL light source with selected bandpass filter are equivalent.
In one aspect, a kind of bandpass filter, with the 595nm laser equivalent of irradiation on skin tissues；It is describedBandpass filter be configured to make through the light of the filter substantially within the scope of 560nm to 690nm.The light can be withIt is IPL light source.
In one aspect, a kind of bandpass filter, with the 755nm laser equivalent of irradiation on skin tissues；It is describedBandpass filter be constructed such that through the light of the filter substantially within the scope of 700nm to 800nm.The light canTo be IPL light source.
On the other hand, a kind of device of the cosmetic treatments of the vascular lesion on skin histology, wherein described device beThe equivalent of the laser of operation wavelength with 595nm comprising the source intense pulsed light (IPL), the source IPL are can to activate's；Bandpass filter, when activating, stop to issue from the source IPL is substantially all in addition to wave-length coverageLight；When activating, the bandpass filter allows the light within the scope of about 560nm to about 690nm from the source IPLTransmission；The IPL with the bandpass filter provides the cosmetic treatments with the laser equivalent that operation wavelength is 595nm.
It yet still another aspect, a kind of device of the cosmetic treatments of the vascular lesion on skin histology, wherein described deviceIt is the equivalent with the laser of operation wavelength of 755nm comprising the source intense pulsed light (IPL), the source IPL are can to swashLiving；Bandpass filter stops substantially the owning in addition to wave-length coverage issued from the source IPL when activatingLight；When activating, the bandpass filter allows the light within the scope of about 700nm to about 800nm from the source IPLTransmission；The IPL with the bandpass filter is provided and operation wavelength is at the beauty of laser equivalent of 755nmReason.
Detailed description of the invention
Fig. 1 illustrates blood and passes through the absorption of the light of different wave length.
Fig. 2 shows absorption coefficient shown in Fig. 1 by table.
Fig. 3 shows absorption of the light to melanin of different wave length with figure.
Fig. 4 shows absorption coefficient shown in Fig. 3 by table.
Fig. 5 graphically illustrates the ratio of the absorption coefficient of light in melanin and blood with the variation of wavelength.
Fig. 6 graphically illustrates the penetration depth that the light under various wavelength enters tissue.
Fig. 7 illustrates the relative efficiency of IPL light source with different wave length.
Fig. 8 and 9 shows the exemplary value of the optical absorption of different chromophories at different wavelengths in a tabular form.
Specific embodiment
The absorption coefficient of light is the function of wavelength in tissue or chromophore.Referring now to Figure 1, the light showing in whole blood is inhaledThe letter of the wavelength of receipts value and " 532 laser filter " that is indicated with " solid line " and " the dye laser filter " that is indicated with " dotted line "Number relational graph.In this nonlimiting, it is assumed that blood is average by about 70% oxyhemoglobin and 30% deoxidationHemoglobin composition.As can be seen that absorption level changes with wavelength.
Fig. 2 shows the tables comprising selected numerical value derived from the chart of Fig. 1.Alternatively, Fig. 3 is shown in melaninThe absorption value of light is with the curve graph of wavelength change, and Fig. 4 provides selected numerical value obtained in the chart from Fig. 3.The column of Fig. 8 and 9The exemplary value of the optical absorption of different chromophories at different wavelengths is gone out.The average absorption that will be provided below as embodimentCalculating is based on these numerical value.
For example, from figure 2 it can be seen that the blood absorption coefficient that wavelength is 532nm is about 232l/cm.Therefore, according to thisThis aspect of invention, the bandpass filter for IPL system can provide in the range of 525 to 585nm, as shown in figure 1 instituteShow, as " 532 laser filter " handled for vascular lesion, and as shown in figure 9, Fig. 9 shows the reality of wave-length coverageExample is applied, is alternatively used for providing the average eguivalent absorption coefficient provided by laser.Mean absorption coefficient refers to should in bloodAll wavelengths in range are equal to 232 1/cm, characterize the absorptivity of 532KTP laser in blood.Therefore, it is contemplated that there is thisThe IPL system of kind bandpass filter has tissue interaction similar with 532nm laser on the skin, and may controlIt is effective as 532nm laser to treat vascular lesion aspect.
Another embodiment as shown in Figure 2, the absorption coefficient of the dye laser that wavelength is about 595nm in blood is aboutFor 60 1/cm.Mean absorption coefficient value of the bandpass filter between 560nm and 690nm has in blood and dye laserThe identical mean absorption coefficient of device, therefore, according to this aspect of the invention, the bandpass filter with 560nm to 690nmIPL system, as shown in Fig. 2, " dye laser filter ", can be used for treating vascular lesion.
As another embodiment, referring now to Figure 3, alexandrite laser (755nm) has about in melaninThe absorption coefficient of 172l/cm, as shown in Figure 3.For example, the bandpass filter from 700nm to 800nm is by spectrum, it is average blackThe absorption coefficient of pigment is therefore 173l/cm according to this aspect of the invention, is provided with 700nm between 800nmThe IPL system of bandpass filter, it is equivalent with alexandrite laser, and referred to here as " alexandrite laser filter ".Similar result can be provided by the bandpass filter of the spectrum of 675nm to 900nm.
Fig. 8 is the table with the embodiment of wave-length coverage, can choose these wave-length coverages to provide in IPL deviceThe equivalent mean absorption coefficient with alexandrite laser.This IPL system may be considered that and be used to treat hyperpigmentary disordersThe alexandrite laser of change has identical or closely similar clinical effectiveness.
According to another aspect of the present invention, a kind of IPL system can be provided, with IPL handpiece, handpiece toolIt is permanently embedded formula filter, which is configured as accommodating bandpass filter, and bandpass filter transmission has average inhaleThe spectrum of coefficient is received, the mean absorption coefficient is about similar to a kind of absorption coefficient of known laser device, for example, for exampleKTP, 532nm, pulsed dye laser (PDL) 585nm-595nm, alexandrite 755nm, diode laser 800-810nm,And Nd:YAG 532, ruby 694nm or l, 064nm or more.
According to another aspect of the invention, the IPL system with IPL handpiece can be configured as receiving according to the present inventionDifferent filters so that single handpiece be transmitted in can be interchanged on destination organization or chromophore have with it is equivalent knownThe spectrum of the similar mean absorption coefficient of laser.The device for being manufactured by assignee of the present invention and being sold, IsraelLumenis LTD is named as M22 general purpose I PL (M22Universal IPL), be receive different filters this device oneA embodiment.
It can carry out in different ways a series of with a certain spectral correlation connection as described above by bandpass filterThe average computation of absorption value.In the above-described embodiments, the calculating of average value is elementary arithmetic average computation, wherein each wavelength" weight " is similar.
However, as shown in Figure 6, the penetration depth that light enters tissue (such as skin) is variation, and is also wavelengthFunction.Therefore, according to another aspect of the present invention, can be calculated based on weighted average calculation through band according to the present inventionThe mean absorption coefficient of the spectrum of bandpass filter.
Further, since dependence of the penetration depth to wavelength, the spot of different depth will undergo different effective in skinWavelength strength distribution.In general, spectrum is mobile to red direction infrared in the increase of depth.Therefore, according to the present inventionThis aspect, provides a kind of IPL system, and with IPL bandpass filter, the bandpass filter, which is configured as transmission, to be hadThe spectrum of the mean absorption coefficient of destination organization or chromophore, the mean absorption coefficient at predetermined depth in skinKnown laser device absorption coefficient it is similar.
For example, on a skin surface, the alexandrite laser of 755nm is in melanin with the absorption of about 172l/cmValue, as shown in Figure 4.From figure 3, it can be seen that average have absorption value similar with alexandrite laser in melaninSpectrum can be the bandpass filter of 700nm to 800nm.It should be noted that different bandpass filters is average to be producedThe raw spectrum with the mean absorption coefficient similar to alexandrite laser, such as the bandpass filter of 725nm to 775nm.
As described above, preferably reaching transition energy threshold value to realize required clinical effectiveness.Therefore, it should baseBandpass filter is selected in the performance and intensity of lamp, is had and known laser so as not to be provided in only in destination organization or chromophoreThe spectrum of the similar average light absorption of device, and few threshold energy can also be provided to realize clinical effectiveness.Now attentionRotate back into the embodiment about destination organization depth in skin, for the alexandrite laser filter of pigment lesion, due toIn infrared direction it is mobile, be intended to for melanin deeper in skin, it may be necessary to transmit slightly different to blue directionMobile spectrum, to keep the mean absorbance of transmitted spectrum near 172 1/cm+ in this deeper position.
According to another aspect of the present invention, as shown in fig. 7, the energy of lamp transmitting is also the function of wavelength.In different wavesUnder length, the efficiency of lamp is different, therefore irradiates and transmit different amounts of energy.Therefore, it is put down as set forth above, it is possible to execute weightingCalculate with the uneven Energy distribution of compensating lamp.IPL system and bandpass filter appropriate are configured as being transmitted in weightingOn the basis of average in skin or in skin from anywhere in the spectrum with absorption coefficient value, the absorption coefficient value withBe one aspect of the present invention the absorption coefficient value of known laser device in destination organization or chromophore it is similar.
Fig. 5 shows the ratio of the absorption coefficient of light in melanin and blood with the variation of wavelength.As can be seen thatIn the wave-length coverage of 600nm to 900nm, which is higher than 10.Therefore, according to this aspect of the invention, band logical of the inventionFilter can be configured to through wave spectrum, and wherein the ratio between absorption of light is at least above in the absorption of light and blood in melanin10 1/cm.It is expected that higher than the ratio of 10 1/cm good selectivity can be generated to the treatment of pigmentosa lesion.According to anotherOne embodiment, IPL system can be configured to transfer ratio greater than 20 1/cm, be greater than 30 1/cm, be greater than 40 1/cm or bigIn the spectrum of 50 1/cm, to further increase selectivity.According to this aspect of the invention and for its other party of the inventionFace, the lamp with high brightness is configured as transmitting high energy flux, therefore, even if also can using relatively narrow bandpass filterIt is enough to realize the threshold energy for being enough to generate clinical effectiveness.
One embodiment of suitable flash lamp for carrying out the present invention can be in the beauty submitted on March 1st, 2017Flash lamp design described in state's provisional application Ser.No 62/465,210.