CN109770848B - Device and method for measuring carbon dioxide release rate - Google Patents
Device and method for measuring carbon dioxide release rateDownload PDFInfo
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- CN109770848B CN109770848BCN201811468851.3ACN201811468851ACN109770848BCN 109770848 BCN109770848 BCN 109770848BCN 201811468851 ACN201811468851 ACN 201811468851ACN 109770848 BCN109770848 BCN 109770848B
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- CURLTUGMZLYLDI-UHFFFAOYSA-NCarbon dioxideChemical compoundO=C=OCURLTUGMZLYLDI-UHFFFAOYSA-N0.000titleclaimsabstractdescription172
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- Measurement Of The Respiration, Hearing Ability, Form, And Blood Characteristics Of Living Organisms (AREA)
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Abstract
Description
Technical Field
The present invention relates to the field of gas measurement, and more particularly, to an apparatus for measuring the rate of carbon dioxide release.
Background
Transdermal carbon dioxide emission (TCE) refers to the amount of carbon dioxide released through the skin and escapes the body surface in very small quantities. In 1984, doctor Eory in hungarian used a small capnometer to measure and compare the TCE of the laogong acupoint and the non-acupoint control region of the pericardium for the first time, and found that the TCE of the acupoint is significantly higher than that of the non-acupoint region, and preliminarily suggested that the acupoint tissue may have higher energy metabolism. Later, Zhang Vibo et al performed a series of experiments using a small capnometer, demonstrating that TCE is associated with energy metabolism, blood absorption, skin permeability, and tissue fluid volume. The percutaneous carbon dioxide partial pressure instrument can be in the in-process of measuring percutaneous carbon dioxide, the carbon dioxide partial pressure that measures when carbon dioxide in the measuring probe and the blood in the capillary vessel reaches the equilibrium in the skin, mainly reflect the carbon dioxide content level in the blood, thereby can be used for the monitoring of hypoxia through reflecting two aspects contents of tissue perfusion flow change and oxygen deficiency metabolism, the monitoring of hypoxia provides a instrument of going deep into the tissue level for the monitoring of shock tissue hypoxia, can the noninvasive continuous monitoring can provide continuous dynamic breathing/oxygen supply information, help the doctor in time master and change, adjust breathing machine parameter.
Although the small-sized carbon dioxide determinator can measure TCE more accurately, the apparatus is complex to maintain and unstable to measure, has inherent defects and cannot be popularized in the industry. The technology for measuring the partial pressure of carbon dioxide through skin is mature at present, is convenient to test, is noninvasive, can continuously and effectively measure, can only reflect the whole energy metabolism level of a human body, and cannot reflect the energy metabolism level of a local measurement part.
Disclosure of Invention
In view of the above problems, the present invention provides an apparatus for measuring a carbon dioxide release rate, the apparatus comprising:
a measuring device that selects a target position to be measured from a plurality of target positions, performs a plurality of measurements on carbon dioxide partial pressure value data of the target position to be measured using a transcutaneous carbon dioxide potentiometer to obtain a plurality of measurement results, and generates a carbon dioxide partial pressure value data curve of the target position to be measured based on the plurality of measurement results;
the extraction device is used for dividing the generated carbon dioxide partial pressure value curve into a plurality of sub-curves, selecting the sub-curve with the smoothest curve change rate from the plurality of sub-curves, and labeling and extracting a curve range from the lowest value in the sub-curve with the smoothest curve change rate to t1 before to t2 after the lowest value, so that the curve range is used as a partial carbon dioxide partial pressure value curve to be detected;
the calculating device is used for calculating the linearity of a numerical curve t2 time of the partial carbon dioxide partial pressure value numerical curve to be detected in a preset time, and obtaining the slope of the fitted numerical curve as the partial pressure change rate;
and the obtaining device is used for obtaining the slope of the multi-time fitting numerical curve so as to determine a plurality of partial pressure change rates, and determining the slope change of the partial pressure change rate according to the plurality of partial pressure change rates.
Alternatively, the time t1 ranges from 2 to 3 seconds.
Alternatively, the time t2 ranges from 25 to 35 seconds.
Optionally, the predetermined time is in the range of 5 to 12 seconds.
Optionally, the fitting is a least squares curve fitting analysis.
The invention also provides a method for measuring the release rate of carbon dioxide, which comprises the following steps:
selecting a target position to be measured from a plurality of target positions, measuring carbon dioxide partial pressure value data of the target position to be measured for a plurality of times by using a percutaneous carbon dioxide partial pressure meter to obtain a plurality of measurement results, and generating a carbon dioxide partial pressure value data curve of the target position to be measured based on the plurality of measurement results;
dividing the generated carbon dioxide partial pressure value numerical curve into a plurality of sub-curves, selecting the sub-curve with the smoothest curve change rate from the plurality of sub-curves, and labeling and extracting a curve range from the lowest value in the sub-curve with the smoothest curve change rate to t1 forward time to t2 backward time to be used as a partial carbon dioxide partial pressure value numerical curve to be detected;
calculating the linearity of a numerical curve t2 time of the partial carbon dioxide partial pressure value numerical curve to be detected in a preset time, and acquiring the slope of the fitted numerical curve as the partial pressure change rate;
and obtaining the slope of the multi-time fitting numerical curve to determine a plurality of partial pressure change rates, and determining the slope change of the partial pressure change rate according to the plurality of partial pressure change rates.
Alternatively, the time t1 ranges from 2 to 3 seconds.
Alternatively, the time t2 ranges from 25 to 35 seconds.
Optionally, the predetermined time is in the range of 5 to 12 seconds.
Optionally, the fitting is a least squares curve fitting analysis.
The invention can quickly, simply and timely measure the carbon dioxide release rate of different parts of an organism and the carbon dioxide emission condition of other objects by utilizing the percutaneous carbon dioxide partial pressure meter, can lay a foundation for better researching channels and collaterals, and is more beneficial to helping doctors to diagnose and make reference for other basic researches and the like.
Drawings
FIG. 1 is a structural view of an apparatus for measuring a carbon dioxide release rate according to the present invention;
FIG. 2 is a flow chart of a method of measuring the carbon dioxide release rate of the present invention.
Detailed Description
The exemplary embodiments of the present invention will now be described with reference to the accompanying drawings, however, the present invention may be embodied in many different forms and is not limited to the embodiments described herein, which are provided for complete and complete disclosure of the present invention and to fully convey the scope of the present invention to those skilled in the art. The terminology used in the exemplary embodiments illustrated in the accompanying drawings is not intended to be limiting of the invention. In the drawings, the same units/elements are denoted by the same reference numerals.
Unless otherwise defined, terms (including technical and scientific terms) used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this invention belongs. Further, it will be understood that terms, such as those defined in commonly used dictionaries, should be interpreted as having a meaning that is consistent with their meaning in the context of the relevant art and will not be interpreted in an idealized or overly formal sense.
The device of the invention contains a liquid in which the carbon dioxide content is diffused from the skin surface into the liquid. Let x be the carbon dioxide concentration in the measurement probe liquid (expressed in partial pressure), c be the steady concentration at which carbon dioxide in the probe is in equilibrium with the tissue, let the change in carbon dioxide concentration in the probe liquid over time follow the diffusion formula, which reflects the change after the carbon dioxide partial pressure reaches the lowest point D, and t be the time, calculated from point D.
dx/dt＝k·(c-x)……………………………………………(1)
Where k is the diffusion coefficient of carbon dioxide in the tissue through the skin.
Obtaining by solution:
x＝c–D exp(-k·t)…………………………………………(2)
ln(c–x)＝-k·t+ln D…………………………………………(3)
t and ln (c-x) are in linear relation
To verify this exponential relationship of carbon dioxide over time, the data was processed. The maximum stable value of the data is found, the carbon dioxide concentration at each time from the point D is subtracted from the maximum stable value, and then the logarithm is taken to obtain a curve of the logarithm and the time variable.
The logarithm of the difference in carbon dioxide concentration varies linearly with time. The logarithm of the concentration difference was linearly regressed with the time variable using SPSS22 statistical software, R2 ＝0.999,F<0.001, the linear regression effect is extremely remarkable.
The present invention provides an apparatus for measuring a carbon dioxide release rate, as shown in fig. 1, the apparatus comprising:
a measuring device that selects a target position to be measured from a plurality of target positions, performs a plurality of measurements on carbon dioxide partial pressure value data of the target position to be measured using a transcutaneous carbon dioxide potentiometer to obtain a plurality of measurement results, and generates a carbon dioxide partial pressure value data curve of the target position to be measured based on the plurality of measurement results;
an extraction device for dividing the generated carbon dioxide partial pressure value curve into a plurality of sub-curves, selecting a sub-curve having the smoothest curve change rate from the plurality of sub-curves,
a typical transcutaneous carbon dioxide partial pressure curve. The curve includes points A-H, where the segment AB is the carbon dioxide value at instrument calibration, about 39 mmHg; at point B, the probe is taken off from the calibration slot, and at the moment, the probe fluctuates to a certain extent and descends rapidly; at point C, the probe is mounted on the retaining ring with a small fluctuation, and then the curve continues to drop to point D; the transition from point D to the rise is not linear but does not occur in the very first phase. From D point to E point, there is a small section of non-linear region whose rise is quick, and near E point, it is changed into linear rise, and from E point to F point, it is a better linear interval, it is a data segment for calculating TCER, and from F, there is still a large section of better linear region, its slope is basically identical to that of EF section, and when it is reached to G point, the slope is reduced, and finally it is level, and at H point the curve is basically reached, and its value is inThe change in time is not more than 0.1mmHg within 1-2 minutes, and the value is determined as TcPCO of the part2 The value is obtained.
And (3) a percutaneous carbon dioxide partial pressure curve, wherein AB is a calibration section, B point is taken down, C point is taken down, the probe is placed on a fixing ring, D point is the lowest point of the curve, EF is a linear rising area, the slope of the linear rising area is TCER, G point is a linear area ending, the slope begins to decrease, and H point is a stable value after the slope is basically horizontal, namely TcPCO 2.
During actual measurement, a section of data from the point D to the point F is selected, and the section of data is automatically identified and processed by using software written by Matlab, so that the slope of the section EF is obtained, defined as TCER and the unit is mmHg/s.
The time t1 onwards from the lowest value in the sub-curve where the curve rate of change is smoothest includes: 2 seconds, 2.5 seconds, 2.8 seconds, or 3 seconds, to a minimum backward t2 time including: marking and extracting curve ranges between 25 seconds, 28 seconds, 30 seconds or 35 seconds to be used as a partial carbon dioxide partial pressure value numerical curve to be detected;
the calculating device is used for calculating the preset time within the time of a numerical curve t2 of the partial carbon dioxide partial pressure value numerical curve to be measured, and comprises the following steps: linearity of 7 seconds, 8 seconds, 9 seconds or 10 seconds, and obtaining the slope of a fitting numerical curve as a partial pressure change rate according to least square method curve fitting analysis;
and the acquisition device acquires the slope of the multi-fitting numerical curve to determine a plurality of partial pressure change rates, and determines the slope change of the partial pressure change rate according to the plurality of partial pressure change rates.
The present invention also provides a method for measuring a carbon dioxide release rate, as shown in fig. 2, comprising:
a measuring device that selects a target position to be measured from a plurality of target positions, performs a plurality of measurements on carbon dioxide partial pressure value data of the target position to be measured using a transcutaneous carbon dioxide potentiometer to obtain a plurality of measurement results, and generates a carbon dioxide partial pressure value data curve of the target position to be measured based on the plurality of measurement results;
an extraction device for dividing the generated carbon dioxide partial pressure value curve into a plurality of sub-curves, selecting a sub-curve with the smoothest curve change rate from the plurality of sub-curves, and advancing to t1 time from the lowest value of the sub-curve with the smoothest curve change rate to include: 2 seconds, 2.5 seconds, 2.8 seconds, or 3 seconds, to a minimum backward t2 time including: marking and extracting curve ranges between 25 seconds, 28 seconds, 30 seconds or 35 seconds to be used as a partial carbon dioxide partial pressure value numerical curve to be detected;
the calculating device is used for calculating the preset time within the time of a numerical curve t2 of the partial carbon dioxide partial pressure value numerical curve to be measured, and comprises the following steps: linearity of 7 seconds, 8 seconds, 9 seconds or 10 seconds, and obtaining the slope of a fitting numerical curve as a partial pressure change rate according to least square method curve fitting analysis;
and the obtaining device is used for obtaining the slope of the multi-time fitting numerical curve so as to determine a plurality of partial pressure change rates, and determining the slope change of the partial pressure change rate according to the plurality of partial pressure change rates.
The invention can quickly, simply and timely measure the carbon dioxide release rate of different parts of an organism and the carbon dioxide emission condition of other objects by utilizing the percutaneous carbon dioxide partial pressure meter, can lay a foundation for better researching channels and collaterals, and is more beneficial to helping doctors to diagnose and make reference for other basic researches and the like.
Claims (10)
1. An apparatus for measuring a rate of carbon dioxide release, the apparatus comprising:
the device comprises a measuring device, a control device and a processing device, wherein the measuring device selects a target position to be measured from a plurality of target positions, uses a percutaneous carbon dioxide partial pressure meter to measure carbon dioxide partial pressure value data of the target position to be measured for a plurality of times so as to obtain a plurality of measuring results, and generates a carbon dioxide partial pressure value curve of the target position to be measured based on the plurality of measuring results;
the extraction device is used for dividing the generated carbon dioxide partial pressure value curve into a plurality of sub-curves, selecting the sub-curve with the smoothest curve change rate from the plurality of sub-curves, and labeling and extracting a curve range from the lowest value in the sub-curve with the smoothest curve change rate to t1 before to t2 after the lowest value, so that the curve range is used as a partial carbon dioxide partial pressure value curve to be detected;
the calculating device is used for calculating the linearity of a numerical curve t2 time of the partial carbon dioxide partial pressure value numerical curve to be detected in a preset time, and obtaining the slope of the fitted numerical curve as the partial pressure change rate;
the acquisition device acquires the slope of the multi-fitting numerical curve to determine a plurality of partial pressure change rates, and determines the slope change of the partial pressure change rate according to the plurality of partial pressure change rates;
the carbon dioxide partial pressure value numerical curve comprises points A-H, wherein AB is a calibration section, point B is taken down from the probe, point C is to place the probe on a fixed ring, point D is the lowest point of the curve, EF is a linear rising area, the slope of the linear rising area is the percutaneous carbon dioxide release rate TCER, point G is the linear area ending, the slope begins to reduce, point H is a stable value after the slope is basically horizontal, and the change of the point H within 1-2 minutes is not more than 0.1 mmHg.
2. The apparatus of claim 1, wherein said time t1 is in the range of 2 to 3 seconds.
3. The apparatus of claim 1, wherein said time t2 is in the range of 25 to 35 seconds.
4. The apparatus of claim 1, wherein said predetermined time is in the range of 5 to 12 seconds.
5. The apparatus of claim 1, wherein said fitting is a least squares curve fit analysis.
6. A method of measuring a rate of carbon dioxide release, the method comprising:
selecting a target position to be measured from a plurality of target positions, measuring the carbon dioxide partial pressure value data of the target position to be measured for a plurality of times by using a percutaneous carbon dioxide partial pressure gauge to obtain a plurality of measuring results, and generating a carbon dioxide partial pressure value curve of the target position to be measured based on the plurality of measuring results;
dividing the generated carbon dioxide partial pressure value numerical curve into a plurality of sub-curves, selecting the sub-curve with the smoothest curve change rate from the plurality of sub-curves, and labeling and extracting a curve range from the lowest value in the sub-curve with the smoothest curve change rate to t1 forward time to t2 backward time to be used as a partial carbon dioxide partial pressure value numerical curve to be detected;
calculating the linearity of a numerical curve t2 time of the partial carbon dioxide partial pressure value numerical curve to be detected in a preset time, and acquiring the slope of the fitted numerical curve as the partial pressure change rate;
obtaining the slope of the multi-time fitting numerical curve to determine a plurality of partial pressure change rates, and determining the slope change of the partial pressure change rate according to the plurality of partial pressure change rates;
the carbon dioxide partial pressure value numerical curve comprises points A-H, wherein AB is a calibration section, point B is taken down from the probe, point C is to place the probe on a fixed ring, point D is the lowest point of the curve, EF is a linear rising area, the slope of the linear rising area is the percutaneous carbon dioxide release rate TCER, point G is the linear area ending, the slope begins to reduce, point H is a stable value after the slope is basically horizontal, and the change of the point H within 1-2 minutes is not more than 0.1 mmHg.
7. The method of claim 6, wherein the time t1 ranges from 2 to 3 seconds.
8. The method of claim 6, wherein said time t2 is in the range of 25 to 35 seconds.
9. The method of claim 6, wherein the predetermined time is in the range of 5 to 12 seconds.
10. The method of claim 6, wherein said fitting is a least squares curve fit analysis.
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Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN2274772Y (en)* | 1996-01-31 | 1998-02-18 | 张维波 | Detector for paucity of carbon dioxide |
| CN1988849A (en)* | 2004-05-18 | 2007-06-27 | 雷迪奥米特巴塞尔股份公司 | Process for measuring partial transcutaneous co2 pressure at an ear lobe |
| CN107703269A (en)* | 2017-11-21 | 2018-02-16 | 中国农业大学 | Towards the monitoring device and method of fruits and vegetables Cold Chain Logistics respiratory rate |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP3409096B2 (en)* | 1994-11-28 | 2003-05-19 | 良介 村山 | Packaging material for carbon dioxide measurement |
| US8652040B2 (en)* | 2006-12-19 | 2014-02-18 | Valencell, Inc. | Telemetric apparatus for health and environmental monitoring |
| DK2144555T4 (en)* | 2007-04-27 | 2022-06-20 | Sentec Ag | Device and method for transcutaneous determination of blood gases |
- 2018
- 2018-12-03CNCN201811468851.3Apatent/CN109770848B/enactiveActive
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN2274772Y (en)* | 1996-01-31 | 1998-02-18 | 张维波 | Detector for paucity of carbon dioxide |
| CN1988849A (en)* | 2004-05-18 | 2007-06-27 | 雷迪奥米特巴塞尔股份公司 | Process for measuring partial transcutaneous co2 pressure at an ear lobe |
| CN107703269A (en)* | 2017-11-21 | 2018-02-16 | 中国农业大学 | Towards the monitoring device and method of fruits and vegetables Cold Chain Logistics respiratory rate |
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