Plugging deviceTechnical field
The invention belongs to interventional medical device technical fields, and in particular to a kind of closure dress for occluding body inner openingIt sets.
Background technique
Aneurysm is a kind of common vascular diseases, is the lesion or damage due to arterial wall, and forms arterial wall limitationProperty or diffusivity expansion or bulging performance.Aneurysm can occur at any position of arterial system, once aneurysm occursRupture will lead to serious consequence.By taking intracranial aneurysm as an example, intracranial aneurysm is to cause the first cause of disease of subarachnoid hemorrhage,The 3rd is occupied in the cranial vascular disease cause of disease, the death rate and disability rate account for the 22%-25% of mortality of cerebrovascular disease patient, andThe trend being gradually incremented by one.Intracranial aneurysm disease incidence is higher, and investigation result is shown, congenital aneurysm occupies major partCrowd, 40-66 years old most commonly seen, and there are about death before 10% patient admission, autopsy recall rate is about 1-5%, aneurysmRupture first blood the death rate be about 15%-20%, not in time the death rate in diagnosis and treatment 2 years reach 75%-85%, 50% or moreRuptured aneurysm survivor can leave different degrees of deformity.
Aneurysmal primary treatments are that operation folder closes treatment and intervention embolization.Intervention embolization is by tens ofThe development in year, makes great progress, and has become the main method for the treatment of acute arterial tumor rupture haemorrhage at present.Aneurysmal JieEnter treatment mainly include simple Coil embolization, sacculus auxiliary or bracket auxiliary Coil embolization, due to interventional therapy is minimally invasive,Safely, effectively the advantages of, becomes the clinical treatment of many medical expert's first choices at present.Spring ring treatment is as most commonTherapeutic modality still has many restrictions, such as packed density is lower, blood flow causes Repeated Compression impact aneurysm wall, operation multipleIt is miscellaneous and stability is poor in wide neck aneurysm, in addition, many aneurysms need to arrange multiple spring rings.Another treatmentMode is exactly to pass through to place braiding or overlay film frame in the blood vessel, acts on the pressure of aneurysm inner wall by reducing blood flow come pre-Anti- aneurysm rupture.For treating aneurysm, braided support or overlay film frame still have part limitation, lead first of all for adaptation is micro-Pipe, braided support are difficult have lower porosity that blood is stopped to enter aneurysm, next is also possible to stop side branch bloodPipe.
In this regard, it is necessary to be directed to, the stability that surgical procedure present in existing plugging device is complicated, blocks is poor, blocksEffect is undesirable, influences the variety of problems such as side branch vessel, proposes a kind of new plugging device.
Summary of the invention
Itd is proposed the present invention is based on the above variety of problems present in plugging device in the prior art one kind can effectively andThe plugging device for stablizing occluding body inner opening, is achieved through the following technical solutions:
The invention proposes a kind of plugging devices, with compressed configuration and the exhibition formed from the compressed configuration through self-expandingOpen configuration, the plugging device includes support section, occluding member and between the support section and the occluding memberOne or more coupling parts, the coupling part has screen resilience under the deployed configuration, when the support section andWhen the occluding member is by its external force close to each other is made, the coupling part drives the support section and the envelopeStifled part is located remotely from each other.
Further, the direction indent where a part of the support section to the occluding member, described a partIncluding at least the part of the outer surface corresponding with the tie point of the coupling part of the support section.
Further, the shape of the occluding member is at least one of the following or combinations thereof: spherical, cylindricality or truncated coneThe bodily form.
Further, the occluding member includes the first closeouts and the second closeouts being connected from the distant to the near, describedFirst closeouts are spherical or in flat, and second closeouts are cylindricality.
Further, the plugging device further includes at least one stop portions, and the stop portions are located at the supportBetween part and the occluding member；When the stop portions are one, the coupling part includes at least one first sectionWith at least one the second section, the stop portions are connect with the support section by least one described first section, instituteIt states stop portions and is connect with the occluding member by least one described second section；When the stop portions are multiple, instituteStating coupling part includes at least one first section, at least one second section and at least one third section, the blocking portionDivide and connect with the support section by least one described first section, the stop portions and the occluding member pass through instituteThe connection of at least one second section is stated, is connected between two adjacent stop portions by least one described third sectionIt connects.
Further, under the deployed configuration, the radical length of the stop portions is greater than or equal to the closure partThe radical length divided.
Further, the coupling part helically rises shape or polyline shaped.
Further, the coupling part includes at least one spherical in shape or shuttle shape segment, and when the segment have it is moreWhen a, multiple segments are connected in series.
Further, one or more layers choked flow film is equipped on the support section and/or the occluding member.
Further, the plugging device further includes at least one locating part, described at least one locating part respective oneEnd is connect with the support section respectively, and the other end is connect with the occluding member respectively.
The present invention has the advantages that
Plugging device proposed by the present invention can be by coupling part under deployed configuration for treating aneurysmScreen resilience realizes that support section is resisted against on aneurysmal distal end inner wall and occluding member is resisted against near the oral area of aneurysm proximal endInner wall on, effectively blocked to realize, not only block tight, and placement of the plugging device in aneurysm is more firm,Not easily to fall off or offset.Further, since being assisted without release bracket in the blood vessel, therefore operation difficulty is small, while also canThe case where enough avoiding the implantation of bracket from resulting in blockage neighbouring blood vessel.
Detailed description of the invention
By reading the following detailed description of the preferred embodiment, various other advantages and benefits are common for this fieldTechnical staff will become clear.The drawings are only for the purpose of illustrating a preferred embodiment, and is not considered as to the present inventionLimitation.And throughout the drawings, the same reference numbers will be used to refer to the same parts.In the accompanying drawings:
Fig. 1 is a kind of structural schematic diagram of the plugging device of embodiment 1；
Fig. 2 is that the structure that the plugging device of Fig. 1 deforms when support section and occluding member are by external force is shownIt is intended to；
Fig. 3 is that the plugging device of Fig. 1 is contained in the structural schematic diagram in microtubular；
Fig. 4 is the blood pressure distribution schematic diagram that plugging device is implanted into before aneurysm；
Fig. 5 is to implement the schematic diagram blocked to aneurysm after the plugging device of Fig. 1 is unfolded in aneurysm；
Fig. 6 be embodiment 1 plugging device occluding member another structural schematic diagram (occluding member include the first envelopeBlocking piece and the second closeouts)；
Fig. 7 is another structural schematic diagram of the plugging device of embodiment 1 (coupling part is using spherical segment)；
Fig. 8 is another structural schematic diagram (segment that coupling part uses shuttle shape) of the plugging device of embodiment 1；
Fig. 9 is the schematic diagram for the network management being woven by single or more braided wires；
Figure 10 is to be attached and pass through after being separately woven into support section, coupling part and occluding member by more braided wiresThe structural schematic diagram of plugging device made of thermal finalization；
Figure 11 is that the plugging device of Figure 10 is contained in the structural schematic diagram in microtubular；
Figure 12 is to implement the schematic diagram blocked to aneurysm after the plugging device of Figure 10 is unfolded in aneurysm；
Figure 13 is the schematic diagram in the occluding member setting choked flow film of the plugging device of Fig. 1；
Figure 14 is the structural schematic diagram of the plugging device of embodiment 2；
Figure 15 is to implement the schematic diagram blocked to aneurysm after the plugging device of Figure 14 is unfolded in aneurysm；
Figure 16 is the structural schematic diagram of the plugging device of embodiment 3；
Figure 17 is the structural schematic diagram of the plugging device of embodiment 4.
Respectively label is expressed as follows in attached drawing:
1: plugging device, 101: support section, 102: occluding member, 1021: the first closeouts, 1022: the second closeouts,103: coupling part, 1031a: segment, 1031b: segment, 105: the first fixing pieces, 106: the second fixing pieces, 4: microtubular, 41:Developing mark point, 5: micro-wire, 6: choked flow film, 10: aneurysm, 15: network management, 18: proximal end oral area；
1b: plugging device, 101b: support section, 102b: occluding member, 103b: coupling part；
1c: plugging device, 101c: support section, 102c: occluding member, 103c: coupling part, 104c: stop portions；
1d: plugging device, 101d: support section, 102d: occluding member, 103d: coupling part；104d: locating part.
Specific embodiment
The illustrative embodiments of the disclosure are more fully described below with reference to accompanying drawings.Although showing this public affairs in attached drawingThe illustrative embodiments opened, it being understood, however, that may be realized in various forms the disclosure without the reality that should be illustrated hereThe mode of applying is limited.It is to be able to thoroughly understand the disclosure on the contrary, providing these embodiments, and can be by this public affairsThe range opened is fully disclosed to those skilled in the art.
It should be understood that term used herein merely for description particular example embodiment purpose, and have no intention intoRow limitation.Unless the context clearly indicates otherwise, otherwise singular " one " as used in the text, "one" and " described "Can also indicate to include plural form.The terms "include", "comprise", " containing " and " having " are inclusives, and thereforeIt indicates the presence of stated feature, step, operations, elements, and/or components, but presence or addition one or more is not precludedA other feature, step, operation, component, assembly unit, and/or their combination.Method and step, process, the Yi Jicao of described in the textIt is not interpreted as that them is necessarily required to execute with described or explanation particular order, executes sequence unless explicitly stated otherwise.Also answerThe step of working as understanding, can be used additionally or alternatively.
Although can be described in the text using term first, second, third, etc. multiple element, component, region, layer and/Or section, still, these component, assembly units, region, layer and/or section should not be limited by these terms.These terms can be onlyFor a component, assembly unit, region, layer or section are distinguished with another region, layer or section.Unless context clearly refers toOut, do not implied that when otherwise the term and other numerical terms of such as " first ", " second " etc use in the text sequence orPerson's order.Therefore, first element discussed below, component, region, layer or section are in the introduction for not departing from example embodimentIn the case of can be referred to as second element, component, region, layer or section.
For ease of description, an element as illustrated in the diagram can be described use space relativeness term in the textEither feature is relative to another element or the relationship of feature, these relativeness terms are, for example, " inside ", " outside ", " interiorSide ", " outside ", " following ", " lower section ", " above ", " top " etc..This spatial correlation term is intended to include removing to retouch in figureThe different direction of device in use or operation except the orientation drawn.For example, being retouched if the device in figure is overturnState for " below other elements or feature " either the element " below other elements or feature " will then be orientated "Above other elements or feature " either " above other elements or feature ".Therefore, exemplary term " in ... lower section " canTo include in orientation upper and under.In addition device can be oriented and (be rotated by 90 ° or in other directions) and used hereinSpatial correlation descriptor correspondingly explains.
In interventional medical device field, it will generally be implanted into the closer apart from operator of human body or the intracorporal medical instrument of animalOne end be known as " proximal end ", " distal end " will be known as apart from the farther away one end of operator, and and define medical instrument according to this principle" proximal end " and " distal end " of either component." axial direction " generally refers to length direction of the medical instrument when being conveyed, " radial direction " oneAs refer to the direction vertical with its " axial direction " of medical instrument, and define according to this principle " the axis of the either component of medical instrumentTo " and " radial direction ".
In addition it is also necessary to explanation, plugging device of the invention cannot be only used for aneurysm closure, it may also be used for Zuo XinThe application scenarios such as ear closure, will not enumerate herein.Below the present invention will be discussed in detail and block dress so that aneurysm blocks as an exampleThe each embodiment set.
Embodiment 1
As depicted in figs. 1 and 2, the present embodiment proposes a kind of plugging device 1, has the pressure that can be housed in microtubular 4Contracting configuration (as shown in Figure 3) and the original configuration under natural conditions as shown in Figure 1 formed through self-expanding by compressed configuration orDeployed configuration after the tissue shown in Fig. 2 that implants, axial length of the plugging device 1 under compressed configuration, which is greater than it, to be unfoldedVertical height under configuration and original configuration.It should be noted that plugging device 1 under original configuration only by gravity,Not only by gravity under deployed configuration, also by in-vivo tissue to plugging device 1 towards its internal extruding force.Block dressSetting 1 includes that 101, occluding members 102 of a support section and a coupling part 103, coupling part 103 are connected to supportBetween part 101 and occluding member 102.
In another embodiment, plugging device 1 may include multiple coupling parts 103, and multiple coupling parts 103 are both connected toBetween support section 101 and occluding member 102, when plugging device 1 is squeezed by external force, 103 institute of coupling part can be enhancedThe screen resilience that can be provided effectively blocks to more securely realize.Further, in another embodiment, plugging device 1 can wrapMultiple support sections 101 for being able to be close to in-vivo tissue inner wall are included, each support section 101 connects at least one interconnecting pieceDivide 103, while to guarantee that coupling part 103 is capable of providing enough screen resiliences, plugging device 1 is made to can adapt to that there is differenceThe in-vivo tissue of cavity body structure.
Plugging device 1 has shape memory, it is thus possible to from when constraint of the compressed configuration in tubular assemblies such as no sheathsOriginal configuration of the self-expanding for deployed configuration or under natural conditions.Coupling part 103 has screen resilience under deployed configuration, works as branchWhen support part points 101 and occluding member 102 are by its external force close to each other is made, coupling part 103 is deposited due to screen resilienceAnd drive support section 101 and occluding member 102 to be located remotely from each other.
Plugging device 1 can be used for blocking the in-vivo tissues structure such as aneurysm, left auricle of heart, it may also be used for block have opening andOther allied organization's structures of inner cavity.For blocking aneurysm 10 as shown in Figure 4, by plugging device 1 in aneurysm 10After release, support section 101 and occluding member 102 are respectively by inner wall near the distal end inner wall of aneurysm 10 and proximal end oral area 18Extruding force, keep support section 101 and occluding member 102 close to each other, and coupling part 103 drives under the action of screen resilienceSupport section 101 and occluding member 102 are located remotely from each other, so that it is resisted against support section 101 on the distal end inner wall of aneurysm 10,Occluding member 102 is resisted against on the inner wall near the proximal end oral area 18 of aneurysm 10, and then is realized to the effective of proximal end oral area 18It blocks, structural schematic diagram and plugging effect after closure please refer to Fig. 5.
The plugging device 1 that the present embodiment is proposed can be realized under deployed configuration by the screen resilience of coupling part 103Support section 101 be resisted against on the distal end inner wall of aneurysm 10 and occluding member 102 to be resisted against 10 proximal end oral area 18 of aneurysm attachedOn close inner wall, effectively blocks, not only block tightly, and placement of the plugging device 1 in aneurysm 10 is more to realizeIt is firm, not easily to fall off or offset, further, since being assisted without release bracket in the blood vessel, therefore operation difficulty is small, simultaneouslyAlso it can be avoided the case where implantation of bracket results in blockage to neighbouring blood vessel.
In embodiment 1, support section 101 is spherical in as illustrated in fig. 1 or fig. 2, when plugging device 1 is implanted into aneurysmAfter 10, towards the inside of plugging device 1 a degree of gathering (as shown in Figure 2) occurs for the marginal portion of support section 101, fromAnd be bonded with the inner wall of aneurysm 10 it is closer, make support section 101 provide support it is more firm.In another embodiment,Support section 101 can also be the shapes such as cylinder, square column type, the truncated cone bodily form, inside can be hollow structure, orNon-hollow structure.Occluding member 102 blocks after plugging device 1 is implanted into aneurysm 10 in as shown in Figure 1 or 2 sphericalThe marginal portion of part 102 is since the inner wall near the proximal end oral area 18 with aneurysm 10 is bonded, thus towards plugging device 1A degree of gathering (as shown in Figure 2) occurs for inside, to realize the effective closure for treating closure site.In another embodimentIn, occluding member 102 can also be one or a combination set of shapes such as cylinder, the bodily form of falling truncated cone, herein with no restrictions, it should be understood thatTo be included within the scope of protection of the present invention, inside can be hollow structure, or non-hollow structure.It needs to illustrate, the bodily form of falling truncated cone indicate by the truncated cone bodily form be inverted after structure.
In another embodiment, referring to FIG. 6, occluding member 102 includes the first closeouts being connected from the distant to the near1021 and second closeouts 1022, the first closeouts 1021 are spherical or in flat, and the second closeouts are cylindricality 1022.It shouldOccluding member 102 in embodiment when blocking the proximal end oral area 18 of aneurysm 10, fill in proximal end oral area by the second closeouts 1022In 18, tentatively to block proximal end oral area 18；Near the marginal portion fitting 10 proximal end oral area 18 of aneurysm of first closeouts 1022Inner wall, thus with the second closeouts 1022 cooperate further sealing proximal end oral area 18 so that blood flow be more difficult to enter aneurysmIn 10, sealing effect is more preferable.
Coupling part 103 is in polyline shaped as depicted in figs. 1 and 2, and in other embodiments, coupling part 103 can be withSpiral uprising shape or other any shapes that screen resilience can be generated when being compressed for spring-like.Into oneStep ground, after guaranteeing that plugging device 1 discharges in aneurysm 10, coupling part 103 is to support section 101 and occluding member 102With enough support forces, while support section 101 will not be released into the distal end of aneurysm 10 due to screen resilience is excessive again and ledIt causes aneurysm 10 to rupture, will not can not play a supporting role because screen resilience is too small, in the present embodiment, coupling part 103The value range of coefficient of elasticity is 0.000125N/mm~0.0005N/mm, can be surveyed by tools such as existing puller systemsAmount.
In another embodiment, as shown in Figure 7 and Figure 8, the coupling part 103 of plugging device 1 can also use sectional typeDesign, i.e. coupling part 103 include at least one segment 1031a (as shown in Figure 7) the spherical in shape or segment 1031b in shuttle shape(as shown in Figure 8), when segment 1031a (or 1031b) has multiple, multiple segment 1031a (or 1031b) are connected, wherein moreIt can successively join end to end, can also be connected by flexible connector between a segment 1031a (or 1031b).It is set using sectional typeMeter can reduce reaction force when coupling part 103 deforms, so that plugging device 1 be made to be preferably bonded in aneurysm 10While wall, prevent aneurysm 10 from rupturing.Certainly, segment also uses other shapes, however it is not limited to spherical and shuttle shape.
Plugging device 1 is by having high-intensitive metal (such as cobalt alloy, nickel alloy, platinum alloy) or high molecular material to weaveIt forms, or by a variety of there is high-intensitive metal and/or high molecular material to combine highdensity metal (such as platinum) shuffling atNetwork management 15 (as shown in Figure 9) is process by thermal finalization, when unrestrained can self-expanding be original configuration or implantInterior deployed configuration.Wherein, high-intensitive metal or high molecular material can guarantee have after plugging device 1 is implanted into aneurysm 10It is enough elasticity and radial force, highdensity metal can gold make plugging device 1 in CT angiography (CTA), magnetic resonance bloodIts position in the blood vessel can be shown under the equipment such as pipe radiography (MRA).
Plugging device 1 can by the molding network management 15 (as shown in Figure 9) of single or more braided wires integrated by weaving byThermal finalization forms (as shown in Figure 1 or 2), can also be separately woven into support section 101, coupling part by more braided wires103 and occluding member 102 after be attached, then through thermal finalization form (as shown in Figure 10-Figure 12).
As shown in figure 13, further, one or more layers choked flow film 6 is equipped on occluding member 102, choked flow film can bePolymeric membrane (such as PET film).As shown in figure 4, the inner wall of aneurysm 10 is constantly by blood flow before the implantation of plugging device 1Impact force F eventually lead to rupture so that the inner wall of aneurysm 10 constantly expands, is thinning.As shown in figure 5, the present embodiment blocksThe effect of device 1 is exactly to reduce impact of the blood flow to the inner wall of aneurysm 10 after discharging in aneurysm 10, make 10 shape of aneurysmAt an approximate closed cavity, promote the formation of thrombus, to effectively be blocked to aneurysm 10.Blood flows into aneurysm 10Two layers of reticular structure for needing to penetrate occluding member 102 can just enter aneurysm to be made along with the choked flow film 6 being arranged in itBlood is obtained to be more difficult into the cavity of aneurysm 10.
Further, one or more layers choked flow film is equipped on support section 101, choked flow film can be polymeric membrane (exampleSuch as PET film), when in the cavity that blood enters aneurysm 10 to support section 101, into aneurysm 10 blood kinetic energyGreatly reduce, blood could generate impact to aneurysm wall there is still a need for two layers of reticular structure is penetrated again at this time, in support section 101The choked flow film of upper setting, so that blood is more difficult to penetrate support section 101 and generate impact to the inner wall of aneurysm 10.It needsIllustrate, the present embodiment can enter aneurysm 10 not only by complete barrier blood flow to implement to treat, and can also utilizeSuch as reticular structure of occluding member 102, support section 101 come reduce blood entrance flow and flow velocity to making aneurysmBlood clotting in 10 cavitys, to realize that multilayer blocks aneurysm 10.Certainly, the lower plugging effect of the porosity of plugging device 1 is moreGood, 15 braided wires number of network management can be 36,42,72,144 etc., and braided wires number can reach smaller holeRate.
Under original configuration, the vertical height from its top to its bottom of plugging device 1 is 1.5mm~35mm, whereinOccluding member 102 from its top to its bottom vertical height be 0.04mm~30mm, support section 101 from its top toThe vertical height of its bottom is 0.04mm~30mm, and the vertical height from its top to its bottom of coupling part 103 is 1.4mm~35mm, occluding member 102 is 0.5mm~5mm bigger than 18 length of proximal end oral area of aneurysm 10 in radial length, preferably0.5mm~3mm, 2mm~4mm, 3mm~5mm etc..
Plugging device 1 further includes that the first fixing piece 105 of 102 proximal end of occluding member is arranged in and is arranged in support sectionSecond fixing piece 106 of 101 distal ends, when applying contrary pulling force to the first fixing piece 105 and the second fixing piece 106,First fixing piece 105 and the second fixing piece 106 are able to drive plugging device 1 along axial tension, make the diameter of the radial direction of plugging device 1Reduce, hence into compressed configuration, in order to convey in vivo.
Plugging device 1 can be implanted into aneurysm 10 (as in figs. 3 and 11) by microtubular 4 and micro-wire 5, and first is fixedPart 105 is using the casing that can be attached with micro-wire 5.Implantation process is as follows: by the proximal end of plugging device 1 and micro-wire 5Distal end connects；Plugging device 1 is entered to the distal end for being placed in microtubular 4 from the proximal end of microtubular 4, plugging device 1 is at this timeCompressed configuration；The suitable position in aneurysm 10 is sent into the distal end of microtubular 4；Fixed micro-wire 5, withdraws microtubular 4, so that101 slow release of support section of plugging device 1, then self-expanding is unfolded and is bonded with the distal end inner wall of aneurysm 10；It is same againWhen withdraw micro-wire 5 and microtubular 4, and microtubular 4 withdraw that speed will be faster than micro-wire 5 withdraw speed so that withdrawingIn the process, the occluding member 102 of plugging device 1 is also slowly released；Aneurysm 10 is withdrawn in micro-wire 5 and microtubular 4When the oral area 18 of proximal end, fixed micro-wire 5, continuation slowly withdraws microtubular 4, so that the occluding member 102 of plugging device 1 is completeRelease, to realize effective closure to the proximal end oral area 18 of aneurysm 10；Plugging device 1 and micro-wire 5 are finally freed, and willMicrotubular 4 and micro-wire 5 are withdrawn from vivo, and ways of relief can free for machinery, be electrolysed de-, hydrolysis is de- or pyrolysis is de- etc..FinallyThe support section 101 of plugging device 1 is bonded with the distal end inner wall of aneurysm 10, occluding member 102 and 10 proximal end oral area of aneurysmInner wall fitting near 18, coupling part 103 generates screen resilience by compression, to guarantee support section 101 and occluding member 102The stability being bonded with aneurysm 10.
It is possible to further which the developing mark point 41 that can be imaged under contrast apparatus is arranged in the front end of microtubular 4, showShadow mark point 41 is the big metal material (such as gold, platinum, thallium, tantalum etc.) or rare earth material of atom mass rate.
Embodiment 2
Details are not described herein for the plugging device 1b of embodiment 2 and the identical part of the plugging device 1 of embodiment 1, the twoThe main distinction is that in example 2, as shown in Figure 14 and Figure 15, a part of support section 101b is arranged to occluding memberDirection indent where 102b, a part described herein include the tie point pair with coupling part 103b of support section 101bThe part for the outer surface answered, be consequently formed on support section 101b towards an inner concave inside plugging device 1b, to keep awayThe distal tip most weakness for exempting from aneurysm 10 bears pressure, is further ensured that aneurysm 10 will not rupture.
In another embodiment, when coupling part, 103b has multiple, all and coupling part of support section 101bThe near sites of 103b connection can be formed towards the direction indent of occluding member 102b on support section 101b in multipleConcave surface.Further, in another embodiment, when support section 101b has multiple, each support section 101b be may each compriseAt least one such inner concave.
Embodiment 3
The identical portion the plugging device 1c of the embodiment 3 and plugging device 1b of plugging device 1 or embodiment 2 of embodiment 1Point details are not described herein, and the main distinction of the two is, in embodiment 3, as shown in figure 16, plugging device 1c can also include stoppingPart 104c, stop portions 104c are used to further decrease the flow velocity of the blood into aneurysm 10, while realizing and treating closureIn-vivo tissue multiple closure.For biggish aneurysm, plugging effect can be promoted by setting stop portions 104c.Stop portions 104c is arranged between support section 101c and occluding member 102c, can be one, is also possible to multiple.WhenWhen stop portions 104c is one, coupling part 103c includes the first section and the second section, stop portions 104c and support portion101c is divided to connect by the first section, stop portions 104c is connect with occluding member 102c by the second section.Work as stop portionsWhen 104c is multiple, coupling part 103c includes the first section, the second section and third section, stop portions 104c and support portion101c is divided to connect by the first section, stop portions 104c is connect with occluding member 102c by the second section, and adjacent twoIt is connected between stop portions 104c by third section.It is appreciated that the first section, the second section, the number of third section canIt is multiple to be arranged, and in position set by it and the present embodiment the first section, the second section, third section setting position oneIt causes, does that role is also identical, and details are not described herein.
In above-described embodiment, under deployed configuration and original configuration, the radical length of stop portions 104c is greater than or equal toThe radical length of occluding member 102c increases envelope to adapt to the cavity body structure being relatively large in diameter at position among the cavitys such as aneurysmBlocking layer realizes multiple closure, improves plugging effect.
Embodiment 4
The part identical with the plugging device of embodiment 1 to embodiment 3 the plugging device 1d of embodiment 4 is no longer superfluous hereinIt states, the main distinction is, in embodiment 4, as shown in figure 17, in order to guarantee between support section 101d and occluding member 102dStationarity, and generate larger reaction force after preventing plugging device 1d to be overly compressed and burst aneurysm, in the present embodimentPlugging device 1d further include at least one locating part 104d, one end of locating part 104d is connect with support section 101d, anotherEnd is connect with occluding member 102d.When support section 101d and occluding member 102d are respectively mobile excessive far from other side, limitPart 104d can reduce excessively moving towards for support section 101d and occluding member 102d, so that it is dynamic to avoid plugging device 1d from burstingArteries and veins tumor.Locating part 104d can be made of metal material, such as Nitinol or cochrome etc., can also be nonmetallic materials,Such as the high molecular materials such as polypropylene or poly terephthalic acid class plastics are made.Locating part 104d is flexible preferable linear part,Locating part 104d includes the curved section of at least one section pre-setting, and curved section can be spring section or broken line, equipped with curved sectionThe length of locating part 104d can change, it is thus possible to and it is consistent with the length of plugging device 1d under compressed configuration, and canDuring plugging device 1d expands into deployed configuration, support section 101d and moving towards for occluding member 102d are playedRestriction effect can both guarantee that support section 101d and occluding member 102d were relatively steady, and can also limit support section 101dThe distance between occluding member 102d bursts aneurysm after avoiding plugging device 1d from being implanted into.
Further, at least two locating part 104d are at least respectively arranged at two opposite sides of coupling part 103d, orPerson is uniformly distributed around the circumferential direction of coupling part 103d, and preferably, the proximal end of at least two locating part 104d is located at envelopeIt near the central axes of stifled part 102d, is distally located near the terminal edge of support section 101d, alternatively, at least two limitsThe distal end of position part 104d is located near the central axes of support section 101d, and proximal end is located at the end of occluding member 102dAdjacent edges.The value model of the angle between straight line or plane and the central axes of plugging device 1d where single locating part 104dEnclosing is 10 ° to 60 °, is convenient for into sheath.
The foregoing is only a preferred embodiment of the present invention, but scope of protection of the present invention is not limited thereto,In the technical scope disclosed by the present invention, any changes or substitutions that can be easily thought of by anyone skilled in the art,It should be covered by the protection scope of the present invention.Therefore, protection scope of the present invention should be with the protection model of the claimSubject to enclosing.