Summary of the invention
The object of the invention is to overcome the deficiencies of the prior art and provide a kind of device for laser therapy, it to be used for eyeground diseaseDisease treatment, compared to traditional medical device, reduces treatment time, realizes that a target area applies one with different-energy densitySecondary laser therapy pattern irradiation, can be on a large scale to patient's continued treatment.Doctor can be made based on the form for the treatment of patternd, to treatmentN (n is natural number) of pattern put to the laser energy setting value of each point of m point (natural number that m is greater than n) and can applyAdd different-energy.Doctor is set to accomplish once irradiating just and make the affected part treatment end of target area have to treatment affected part as far as possibleIt imitates therapeutic purpose region and can be reduced treatment total time.
Technical scheme is as follows:
A kind of device for laser therapy, comprising:
LASER Illuminator System, the LASER Illuminator System include laser light source, by the laser from the laser light sourcePoint output is the switch matrix device of the point of identical or different spot diameter, and by the laser from the switch matrix devicePoint is irradiated to optical scanner's group of eyes of patients destination organization；
Control system, multiple points in the queueing disciplines of irradiation patterns of the control system based on setting, irradiation patternsPosition, the spot size of point, point irradiation duration, the LASER Illuminator System is controlled.
Further, the switch matrix device includes the hot spot for the point that can be selected laser classifications and export category laserThe optical scanner of size；Queueing discipline of the control system according to irradiation patterns, the optical scanner of control switch matrix arrangement,To a series of n-th position as defined in irradiation patterns to click-through with identical or different spot diameter of m-th positionRow irradiation, wherein n is natural number, and m is greater than the natural number of n.
Further, which further includes spot diameter setting module, different in irradiation patterns for settingThe point spot diameter of the point of position makes the spot diameter of the point in laser irradiation pattern correspond to point spot diameter setting numerical value；Described spot diameter is adjusted as needed.
Further, described spot diameter is set as any one point or any number of points in irradiation patterns.
Further, which further includes a spacing setting module, for inputting between the point in irradiation patternsAway from；The control system moves the irradiation position for aiming at the point of light based on the point spacing inputted with described spacing setting moduleIt is dynamic, so that the point for aiming at light corresponds to point spacing arrangement.
Further, in the case where spacing is fixed, the spot diameter of set point；Alternatively, in spot diameter boundIn range, the spot diameter of the point of pattern is set, a spacing is reset；As a result, in the case where the confirmation of the spot diameter of point, noCorresponding spacing of energy is skipped or prevents.
Further, described spot diameter setting module, described spacing setting module are integrated in same operating systemAmong.
Further, irradiation patterns are as needed for arbitrary graphic pattern, the point arbitrary arrangement as needed of irradiation patterns.
Further, which further includes image capturing system (unit), amasthenic lens (group), illumination lightSource；LASER Illuminator System (unit) and image capturing system (unit) installation are inside the shell；Amasthenic lens (lens group) installationOn the shell.
Further, laser light source includes treatment laser light source, aiming laser light source；Switch matrix device is in treatment laserIt is selected between aiming laser；It is being divided into for the center of circle that laser switch matrix arrangement, which has along the rotary shaft of optical scanner,The different spot diameter output lens that multiple included angles are put.With the work changed to the laser spot sizes on eyegroundWith.
Further, LASER Illuminator System has collimation lens (group), optical scanner's group, object lens (group), laser beam expanding saturatingMirror (group) and reflecting mirror；Optical scanning group includes two optical scanner, can make to treat laser in a manner of rotating shaft direct cross(deviation) or mobile is deflected with light is aimed at, and is finally irradiated in the form of arrangement pattern to eyeground；Light-conductive optic fibre will come from lightThe laser of source system is guide-lighting to optical scanning group by collimation lens (group), and laser is pressed x by optical scanner's group, the direction y scan deflection,And from object lens (group) outgoing beam in a manner of the pattern of arrangement；Light beam is deflected by reflecting mirror to amasthenic lens (group), is focusedCamera lens (group) is irradiated by contact lens to eyeground destination organization after focusing light beam.
Further, amasthenic lens (group) be placed in the downstream of LASER Illuminator System, reflecting mirror, image acquisition units canZoom lens/lens group front, amasthenic lens (group) are fixed on the shell.Reflecting mirror, image acquisition units are arranged inAmasthenic lens (group) optical center axis two sides, while the amasthenic lens (group) and the figure acquisition unit are confocal in patientVarifocal zoom lens/lens group three optical centre axis of ocular tissue, amasthenic lens (group) and reflecting mirror, image acquisition unitsLine is not overlapped；When reflecting mirror is not coaxial not with image acquisition units optical centre, it is opposite that image acquisition units institute can be increasedTotal field angle of eye destination organization can be placed in image path without interference images in imaging focal length.
Further, image acquisition units generate electron image by the light of amasthenic lens (group) to realize destination organizationImage, the light of the amasthenic lens (group) include that laser beam focusing is generated to diffuse and returned by luminous ray after ocular tissueThe light returned, also includes the visible light that the eye fundus image generated after ocular tissue is illuminated by the illuminating ray of lamp optical systemLine；The image can be stored by system, display.
Further, control system is planned as a whole using central processing unit CPU and control device, CPU include computer,But it is not limited to computer；Control system respectively with laser source system, operating system (unit), image acquisition units, illuminationLight source, optical scanning group, the optical scanner of matrix switch de-vice, the connection such as signaling switch.
Further, operating system has and is shown, controlled to the image from image acquisition units, for being swashedThe display of setting, the display of light treatment condition etc., and for conventional feed device (mouse, operating stick etc.), generation numberChange the hardware device input unit of mark position.
Further, display is touch-screen type, also serves as display and setting (input) unit is used；Have on display aobviousThe image display cell for showing real-time target tissue has the function of graphical interaction interface (GUI)；Have and can control image acquisition unitsImage control panel；And it can the confirmation of sense of vision, the parameter selection for setting laser beam, treatment means, treatment letter for doctorIt ceases laser and sets panel.
Further, laser setting panel has irradiation patterns setting module, spot diameter setting module, and energy output is setCover half block, irradiation time setting module, parameter setting switch and thin Xiang Kaiguan；Irradiation patterns setting module has pattern pre-If module, quick pattern puts spacing setting module.
The invention has the benefit that
1. the point spot diameter of the point by setting irradiation patterns, irradiates a series for the treatment of laser.Doctor just can saveThe position of device will be adjusted by saving a series for the treatment of ends every time, look for and treat the time of next place eyeground treatment region.
2. by using the primary irradiation position for aiming at light, to the different affected parts of the eyeground sufferer tissue of same target areaPosition and the spot diameter for determining treatment laser, improve the precision for the treatment of.
3. the point spot diameter setting of some point by irradiation patterns, is persistently controlled on a large scale for a series of every timeLaser irradiation is treated, doctor can be easy various situation in reply treatment.
4. the present embodiment makes doctor accomplish once irradiating to treatment affected part just and make the affected part treatment end of target area,Effective therapeutic purpose region and it can be reduced treatment total time.
Specific embodiment
Below in conjunction with specific attached drawing the present invention is described in detail specific embodiment.It should be noted that in following embodimentsThe combination of the technical characteristic or technical characteristic of description is not construed as isolated, they can be combined with each other to reachingTo superior technique effect.In the drawings of the following embodiments, the identical label that each attached drawing occurs represent identical feature orPerson's component, can be apply to different embodiments.
Fig. 2 show a kind of structure diagram of device for laser therapy of the embodiment of the present invention (LASER Illuminator System and control systemSystem).Device for laser therapy 200 has laser source system 60, LASER Illuminator System (unit) 30, image capturing system (unit)20, amasthenic lens (group) 70, control system 80, operating system (unit) 90 and lighting source 100.LASER Illuminator System is (singleMember) 30 and image capturing system (unit) 20 be installed in shell 10.Amasthenic lens (group) 70 is mounted on the shell.SwashRadiant system 60 includes aiming laser light source 61, treats laser light source 64 and laser switch matrix arrangement 50.
Aiming light is generated using light source 61 is aimed at, for identifying the irradiation position for the treatment of laser.Using treatment laser light source64 generate treatment light, for emitting the laser for being suitable for the wavelength for the treatment of.They would generally generate the light of different wave length and power.LightThe aiming light in source 61 be it is macroscopic, the treatment light of light source 64 may be visible, but be not required.Light source 61/64 canTo be any gaseous state or solid-state laser apparatus, or it can be one or more light emitting diodes.
Laser switch matrix arrangement 50 is located between laser source system 60 and LASER Illuminator System (unit) 30.With makingIt treats light or aims at the effect that light Space Coupling enters light-conductive optic fibre 40.It is treated under the reflection of the optical scanner 51 with reflecting mirrorLight or aiming light form and mutually penetrate relationship.It is generated simultaneously it should be noted that aiming at light and treating light, in this case lightScanner 51 utilizes same deflection/deviation angle, treatment light and aiming light reflection for different incidence angles, going out after reflectionFiring angle is also different.Optical scanner 51 is to be controlled based on the command signal from control system 80, by mirror tilt or movementDriving mechanism.For example, light source 61, which will aim at light 63, is transmitted to optical scanner 51 by optical fiber 62.Light source 64 leads to light 66 is treatedIt crosses optical fiber 65 and is transmitted to optical scanner 51.The deflection of optical scanner 51 makes the aiming deflection of light 63 be coupled into light-conductive optic fibre 40.Aim at lightIn deflection, the deflected light-conductive optic fibre 40 out for the treatment of light 66.Opposite, the treatment deflection of light 66 is coupled into light-conductive optic fibre 40, aims atThe deflected light-conductive optic fibre 40 out of light 63.In addition, optical scanner can be current type reflecting mirror, be installed to piezoelectric actuator, servoThe reflecting mirror of motor or the actuator of other classes.It is circle that laser switch matrix arrangement 50, which has along the rotary shaft of optical scanner 51,The heart is divided into the different spot diameter output lens (being detailed in Fig. 3) that multiple included angles are put.
LASER Illuminator System 30 has collimation lens (group) 31, optical scanning group 32, object lens (group) 33, laser beam expanding lens(group) 34 and reflecting mirror 35.The placed upstream of LASER Illuminator System 30 has the exit end of light-conductive optic fibre 40.Light-conductive optic fibre 40 willLight from light-source system 60 is guide-lighting to LASER Illuminator System 30.
Optical scanning group 32 includes two optical scanner (the first optical scanner, the second optical scanner), can be with rotary shaftOrthogonal mode makes to treat laser and aims at light deflection (deviation) or mobile, and is finally irradiated in the form of arrangement pattern to eyeBottom.Light-conductive optic fibre 40 will pass through guide-lighting, the optical scanning to optical scanning group 32 of collimation lens (group) 31 from the laser of light-source system 60Laser is pressed x by device group 32, the direction y scan deflection, and from 33 outgoing beam 36 of object lens (group) in a manner of the pattern of arrangement.LightBeam 36 is deflected by reflecting mirror 35 to amasthenic lens (group) 70, and amasthenic lens (group) 70 passes through opticianry lens after focusing light beam2 irradiate to eyeground destination organization 1.
Amasthenic lens (group) 70 and is focused laser for will be imaged from the light focusing of eyes of patients destination organizationIn the light combination component of eyes of patients destination organization.Amasthenic lens (group) 70 is placed in the downstream of LASER Illuminator System 30, reflecting mirror, figureAs Varifocal zoom lens/lens group front of acquisition system (unit) 20, it is fixed on shell 10.Reflecting mirror 35, Image AcquisitionSystem (unit) 20 is arranged in 70 optical center axis two sides of amasthenic lens (group), at the same the amasthenic lens (group) 70 withThe figure acquisition system (unit) 20 is confocal in eyes of patients tissue, amasthenic lens (group) 70 and reflecting mirror 35, Image AcquisitionThe Varifocal zoom lens of system (unit) 20/lens group three optical center axis is not overlapped.When reflecting mirror is not adopted with imageCollecting system (unit) 20 optical centres of unit are not coaxial, can increase the total of the opposite eye destination organization of image acquisition unitsField angle can be placed in image path without interference images in imaging focal length.
In actual use, opticianry lens 2 are placed in patient at the moment to help ocular tissue 1 to be imaged, opticianryLens 2 can be contact or non-contact mirror, pupil plane is conjugated in conjunction with amasthenic lens (group) 70 to provide, to make the eye of patientThe maximized imaging of tissue.
Using image capturing system (unit) 20, electron image is generated by the light of amasthenic lens (group) 70 to realize targetThe image of tissue.The light of the amasthenic lens (group) 70 includes generating the light to diffuse after light beam 36 focuses on ocular tissue 1Line 21 also includes generating the light 21 to diffuse after illuminating ocular tissue 1 by the illuminating ray 101 of lamp optical system 100.The image can be stored by system, and display, doctor can be convenient safety and see to the eyeground illuminated by lamp optical system 100It examines, confirmation light beam 36 carries out laser irradiation, eye destination organization situation after confirmation treatment in the light-beam position of ocular tissue 1.
Laser source system 60 is connected in the control system 80 be managed to device 200, controlled, operating system is (singleMember) 90, image capturing system (unit) 20, lighting source 100, optical scanning group 32, optical scanner 51, signaling switch 81 etc..ControlSystem 80 processed is planned as a whole using central processing unit (CPU) and control device 200, and CPU includes computer, but is not limited to countCalculation machine.In order to facilitate understanding and describe, computer used below is explained.
Operating system (unit) 90 has, and is shown, is controlled to the image from image capturing system (unit) 20, usesIn the display 92 for setting, the display for carrying out laser therapy condition etc., and it is used for conventional feed device (mouse, operating stickDeng), generate digitized markers position hardware device input unit 91.
Display 92 is touch-screen type, also serves as display and setting (input) unit is used.Have display real on display 92When destination organization 94a image display cell 93, have the function of graphical interaction interface (GUI) 95, can control Image Acquisition systemUnite (unit) 20 image control panel 96, and for doctor can sense of vision confirmation, set laser beam parameter selection, controlTreatment means, treatment information, laser setting panel 97 etc..
Image control panel 96 has image setting module, can set the aspect ratio of image capturing system (unit),Image magnification etc.., can be with the recording of image with image playback controls module, broadcasting etc..
Laser, which sets panel 97, has irradiation patterns setting module 97a, spot diameter setting module 97b, and energy output is setCover half block 97c, the setting module 97d of irradiation time, parameter setting switch 97e, and thin item switch 97f.Irradiation patterns settingModule 97a has pattern preset module 97aa, the quick mode 97ab of pattern, puts spacing setting module 97ac.
It can be with logarithm, option, entry etc. by each setting item of graphical interaction interface (GUI) 95 on touching display 92It is set.The conditions such as the numerical value, option, the entry that are set are stored in the memory of computer, such as hard disk, memory etc..
The energy output (power) for the treatment of laser can be set using energy output setting module.Use setting for irradiation timeCover half block can set the irradiation time (pulse width) for the treatment of laser.It can be setting laser using irradiation patterns setting moduleIrradiation patterns.Touching pattern preset module shows the pattern candidate options that can be set.The touching quick mode of pattern is shownThe irradiation patterns candidate options that secondary starting is irradiated and completed.The presetting module added in touching operation irradiation patterns setting moduleNumerical value a little can be increased and decreased.Point of use spacing setting module can set the point spacing of irradiation patterns.It is set using spot diameterModule can set the size of the diameter of each point of irradiation patterns.Detailed item can be set using parameter setting switchPart.Thin item switchs the switch for drawing other setting modules.
Point spacing setting module is set for setting the numerical value of the spacing between the point in irradiation patterns, as to control80 input point spacing of system and play a role.The point spacing said herein refers to the shortest distance of the dot center of consecutive points.As pointSpacing, defining spacing is 1.0, and spacing is divided by spacing ratio and has prepared 49 sections of spacing from 1.25 to 5.0.ThisScheme point spacing is set to 2.0.
With spot diameter setting module, the diameter of each point in setting irradiation patterns can be switched.Here, irradiationPattern can be the presetting module added in irradiation patterns setting module, be also possible to the irradiation that last time starting is irradiated and completedPattern；The diameter of each point refers to that each point is radiated at the spot size of eyes of patients destination organization.Spot diameter settingModule inputs the spot diameter setting module of the point of different sizes to control system 80 and plays a role.Here, point spacing quiltSetting.
Then, to real-time imaging and in real time, processing is illustrated.Eye target from image capturing system (unit) 20The image position and image proportional of tissue 1 can adjust the position of mobile shell 10 by doctor and realize to manually control, and may be used alsoIt is realized with carrying out Electronic control by using control figure interactive interface (GUI) 95 instruction or control input.
It can be handled in real time using tangibly display 92 and such as operating stick, mouse or other index input units 91Which part of ocular tissue 94 should in the image that image capturing system (unit) 20 is transmitted to tangibly display 92It is treated.The real-time processing of the treatment is accomplished by the following way: the image that image capturing system (unit) 20 is acquired transmitsInto computer, then using the tangibly display 92 of computer and conventional feed device (mouse, operating stick etc.) and productionThe input units 91 such as the software or hardware device of raw digitized markers position, allow doctor's digitized markers to treat in the imageRegion 94a.
Using image capturing system (unit) 20 obtain treatment before, in therapeutic process and treatment after each position shape of patient's eyesThe image of condition, more specifically include handle in real time over the course for the treatment of can sense of vision confirmation, set laser beam parameterThe various parameters information such as selection, treatment means, treatment information are transmitted to computer, are then set using the storage of computer or outputThe modes such as standby (hard disk, network interface card, movable storage device etc.) storage, transmission, upload or downloading manage laser therapy image and data.
In the present solution, the irradiation patterns implemented are to be arranged with the pattern for treating light irradiation position point, and irradiation patterns areThe pattern of one fixed point spacing arrangement.The queueing discipline of point, which can be, freely, arbitrarily to be arranged.For example, random waveShape (Lang Ding of wave and unrestrained bottom, the unrestrained width of wave irregular can arrange) pattern, random strokes and dots line pattern are randomSaw-tooth like pattern.It is also possible to be arranged by geometrics.For example, the figure of 2x2,3x3,4x4,5x5 equal matrix arrangementCase, the pattern of arc-shaped arrangement, the pattern of round arrangement, the pattern etc. linearly arranged.
In the present solution, aim at the point of irradiation position that light is mark treatment light, and based on corresponding irradiation patterns signalEye destination organization indicates irradiation patterns.Illumination will be aimed to be mapped to and treat on identical position of the irradiation position of light.This aiming is stated, and only illustrates the irradiation position of conveniently recognized treatment light, therefore, aiming mode or rule can be varied's.
Here, the random wavy pattern of matrix pattern, Fig. 3 B diagram based on Fig. 3 A diagram is in irradiation patternsThe queueing discipline of point be illustrated.The form of the 3x3 matrix pattern of Fig. 3 A diagram.9 points of Fig. 3 B diagram constitute randomThen wavy pattern.
As shown in Figure 3A, point is well-regulated arrangement, and the center of each point is made to be located at the setting rectangle gone out with broken line representationCentral point be origin coordinate system coordinate position.Treatment light and the point of aiming light are formulated using rectangular coordinates system is erectQueueing discipline.Erect rectangular form point spacing be formulated between consecutive points (direction up and down) dot center most short distanceFrom.Adjacent each point is to be located at coordinate value (x, the y) establishment for erectting rectangular coordinates system by it.Here, a spacing is setIt is set to the size of a point, so that be the size of a point between the dot center of consecutive points.By coordinate value with it is fixed away fromMatrix is just formed from 3x3 arrangement point.Therefore, irradiation patterns are also matrix pattern.The direction up and down of this matrix pattern, between pointAway from all identical of arbitrary point.It is irradiated with matrix pattern and aims at light, doctor can be made to identify the position for the treatment of light.It is shone with matrix patternTreatment light is penetrated, the heat diffusion on each periphery just becomes uniformly, and solidification between points also becomes uniform.Final goal groupTissue region is substantially homogeneously treated.The following matrix pattern just for 3x3 for convenience of explanation, but can be identical or notA variety of irradiation patterns of same type.
When treatment, treatment light is constantly irradiated in the point position determined by irradiation patterns.In the shape of the matrix pattern of 3x3Under formula, doctor is by the signal of trigger signal switch 81, by the regulation of pattern queueing discipline from n-th position to m pointSet constantly irradiation treatment light.N be natural number (n=1,2 ... ..., N), m be the natural number bigger than n (m > n, m=2,3 ... ...,M).It is presetting that n and m corresponds to irradiation patterns.The position of n and m is corresponded to erect rectangular central point as originCoordinate system coordinate position.The irradiation time of irradiation treatment light from n-th position to m point position should be limited to eyeballIn the time that do not move, the irradiation time of light is treated preferably within 1 second.
For example, the matrix pattern of one group of 3x3 of irradiation, is set as the 1st point for n-th point that corresponds to matrix pattern.It willM point is set as last point (the 9th point).From the point S1 of 1st position of matrix pattern towards the point of 9th positionS9 irradiates in sequence.Doctor is in the identification and determination for carrying out eyes of patients destination organization between irradiation aims at the photophase.Once reallyAfter fixed, using a series of irradiations for the treatment of light, treatment just has been irradiated to whole points of the irradiation patterns of eyes of patients destination organizationLight.
Specifically, after the irradiation of point S1, light irradiation will be treated and the side of point S1 (is adjacent the right in figurePoint).Treatment light irradiation time on a point is set as 5~50ms or so, if it is set as 20ms.Therefore, the square of 3x3The treatment laser irradiation time of system of battle formations case is just at 0.2 second.Aforesaid operations are repeated, just from point S1 to point S9, a point is continuedIrradiate seance light.In this way, structural position for corresponding to 3x3 matrix pattern just becomes the irradiation position for the treatment of light.
In addition, although but not limited thereto from n-th point to m point successively irradiation treatment light in described above.Also it does not adviseSurely the sequence irradiated.
Then, it is illustrated about the random wavy pattern of Fig. 3 B.
Point is random arrangement, and it is origin that the center of each point, which is located at the rectangular central point of setting that broken line representation goes out,Coordinate system coordinate position.The queueing discipline for formulating the point for the treatment of light and aiming light using rectangular coordinates system is erect.It erectsThe spacing of rectangular form point is formulated between consecutive points the distance of (any direction).Adjacent each point is to be located to erect by itThe coordinate value (x, y) of rectangular coordinates system is established.Therefore, the distance between point is all identical in any direction.Here, spacing will be putDb setting is identical as point space D a.Random wavy pattern is just formed apart from arbitrary arrangement point by coordinate value with fixed.Due to arbitrary neighborhood point spacing all having the same, with this pattern irradiation treatment light, it is contemplated that ratio matrix pattern solidification have moreGood uniformity.Final goal tissue regions are equably treated.It is following just for the random of 9 points for convenience of explanationWavy pattern, but can be a variety of irradiation patterns of identical or different type.
In based on random wavy pattern treatment, treatment light is constantly irradiated in the point determined by irradiation patternsPosition.The case where with matrix pattern, is the same, from the point S1 of 1st position of random wavy pattern towards the 9th pointThe point S9 of position, for a prolonged exposure seance light.In this way, corresponding to the random wavy pattern of 9 pointsStructural position just become treatment light irradiation position.
The case where irradiation of aiming light, treatment laser in random wavy pattern is with matrix pattern is identical.
Can also be by above-mentioned matrix pattern and random wavy pattern, the setting rectangular coordinates gone out with broken line representationPoint enters rotation status centered on the origin of system.Relationship between point is still based on the coordinate of above-mentioned setting rectangular coordinates systemThe arrangement of point position.
In addition, although but not limited thereto from n-th point to m point successively irradiation treatment light in described above.Also it does not adviseSurely the sequence irradiated.
Then, photocoagulation is illustrated.Fig. 4 is the schematic diagram on eyeground.On the F of eyeground, shows and illuminate the narrow of eyegroundLight SL is stitched, and the schematically point arrangement TLS of the position of irradiation treatment light being irradiated.As the broad range throughout eyegroundThe treatment method of the multiple treatment light of prolonged exposure, such as full retinal photocoagulation PRP.In PRP, other than the macular area on eyegroundRange carries out photocoagulation.In PRP, the treatment light of thousands of beams (point) will be irradiated.Eye ground physiological structure is because of its thicknessIt is gradually thinning to eyeground periphery by macular area.In PRP, treatment light will be used the point of difference by nearly macular area to eyeground peripherySpot diameter carries out photocoagulation, to ensure that the solidifying fuel factor of light can effectively cover corresponding region.In the irradiation of laser, it isConfirmation irradiation destination organization and eyeground destination organization expanded.Destination organization is swashed in the visual field VF expandedLight irradiation.Slit light SL is delivered in eyeground F using lighting source 100, passes through 20 couples of visual field VF of image capturing system (unit)In the range of image collection, be shown in display 92 and carry out object observing tissue.At this moment visual field VF is the width of slit light SLDecades of times or so (carry out signalization for convenience of explanation in Fig. 4).
In order to which treatment light is irradiated in eyeground destination organization with the point of different spot diameters, the irradiation patterns in the VF of the visual fieldNeed to carry out the spot diameter setting operation of photocoagulation for destination organization different zones.Further, as long as in the VF of the visual fieldThe different zones of irradiation destination organization for the treatment of light of destination organization operated it is necessary to change spot diameter.Show in Fig. 4The point being irradiated in slit light SL to the point of multiple treatment light of having anticipated out arranges TLS.
In the case where the visual field VF that slit light SL illuminates, for example, to destination organization different zones preset matrix pattern orThe random wavy pattern of person, and the spot diameter at pattern midpoint needs to set treatment because of the regional location difference of destination organizationThe spot diameter of the point of light.Specifically, control-rod, touch control operation system 90, the setting figure of operation input unit 91 are exactly operatedThe numerical value of the point spot diameter of point in case puts spacing, the energy output of point and irradiation time.
Then, the treatment light based on irradiation patterns is illustrated with the irradiation for aiming at light.Fig. 5 A-C and Fig. 6 A-C isThe figure that the different spot diameters for the point for aiming at the treatment light irradiation after light irradiates are illustrated.
In Fig. 5 A-C, shows and slit light SL illuminated target group is radiated at for light is treated based on 3x3 matrix patternThe example knitted.In Fig. 6 A-C, the random wavy pattern constituted based on 9 points is shown by light is treated and is radiated at slitThe example of light SL illuminated target tissue.
The aiming state illustrated in Fig. 5 A-C and Fig. 6 A-C is formed based on an example for aiming at rule, is madeFor by aim at light be irradiated in laser therapy point position example and use.
Spot diameter setting module 97b is spot diameter setup unit, before the irradiation of a series for the treatment of light, to controllingThe spot diameter for treating the point of the irradiation patterns of light is set.It, can be by irradiation patterns using spot diameter setting module 97bThe spot diameter of each point changes numerical value, and in the case where aiming at light situation, the hot spot for being irradiated to the point of the irradiation patterns of destination organization is bigSmall difference is irradiated to the spot size of the point of the irradiation patterns of destination organization after treatment light light irradiation and aims at the point of light irradiationSpot size it is identical.
In Fig. 5 A-C and Fig. 6 A-C in diagram, the point of irradiation for aiming at light is indicated with black oblique line, fills table with blackShow the point of irradiation (being irradiated) for the treatment of light, the spot after indicating photocoagulation with white oblique line.Fig. 5 A and Fig. 6 A expression are taken aim atQuasi-optical state, after Fig. 5 B and Fig. 6 B indicate that state when treatment light irradiation, Fig. 5 C and Fig. 6 C indicate treatment light irradiationState (point being irradiated can be still irradiated to by aiming at light).
In a situation of fig. 5 a, 3x3 matrix pattern (pattern for aiming at the point of light) is irradiated on region 94a.Based on preparatoryThe corresponding aiming rule irradiation of the matrix pattern of setting aims at light.Touch control operation system 90 is manipulated or touched with input unit 91 to graspMake spot diameter setting module 97b, set the numerical value for needing to change the point Sg of spot diameter in matrix pattern, then setting signal is justIt is transferred to control system 80.Control system 80 is based on setting signal and control program (aiming at rule), controls laser switch squareBattle array device 60, irradiation aim at light.At this point, control system 80 is based on the point space D set with spacing setting module 97ac and comesFrom the signal for showing spot size of control system, the point Sg point spacing for aiming at light irradiation pattern is set to D1；When based on irradiationBetween setting module 97b setting irradiation time t and the signal for showing spot size from control system, it is straight by hot spot is changedThe irradiation time of the point Sg of diameter numerical value is set to t1.The point spot diameter of the point more becomes and the diameter in final irradiation aiming patternThe consistent hot spot dot of numerical value.The illuminated aiming light figure of 93 simultaneous display patient eyeground of image display cell, 94 destination organization 94aThe variation of case.
In a situation of fig. 5 a, once trigger signal switch 81, then laser is controlled in irradiation, it is transitioned into the state of Fig. 5 B.ControlSystem 80 controls laser switch matrix arrangement 60 based on the trigger signal from signaling switch 81, will treatment light prolonged exposure inThe point position of the 3x3 in region 94.It is irradiated as a result, in the different treatment light of the spot diameter of the point of the formation of region 94 3x3 solidifyingSpot soliding point.
Once the irradiation for the treatment of light terminates, then the state of the C of Fig. 5 is transitioned into.Control system 80 is again based on control system80, based on setting signal and control program (aiming at rule), control laser switch matrix arrangement 60, will aim at light and are irradiated in be formedSolidification spot region 94.Region 94 is region identical with the region of controlling laser has been irradiated (before treatment light irradiationAim at the identical position of light irradiation position).
At this point, doctor can carry out aiming to next target area the irradiation of light, during this period, aiming at light will persistently shineIt penetrates.Detailed situation is described further below.
Point spacing setting module 97ac is the spacing setup unit of point, in the queueing discipline of the point of irradiation patterns,The setting of the spot diameter numerical value of point in irradiation patterns depends on the point spacing limit value of a point, and point spacing is by spacing ratio stroke49 sections of spacing point is prepared from 1.25 to 5.0.One spacing of predetermined pattern is defined as 2.0, and the spot diameter of point is100um changes the spot diameter numerical value of the point of pattern in this case, and the change range of each point can be 50-250um.More than the limit value, control system 80 prevents the change of the spot radius of point.In such a case it is possible to change point spacing a little.
Here, being illustrated to the point spacing of the point for the change spot diameter for aiming at light and treatment laser.Fig. 7 A-B is shownThe point spacing of the point of 3x3 pattern, change spot diameter point Sg point spacing.Fig. 7 A shows the point of preset 3x3 patternPoint space D.Fig. 7 B is shown in the point space D 1 based on the point after the spot diameter for changing point Sg in 3x3 pattern.
Fig. 7 A point S1 and point S2 are only separated by a space D.Specifically, the direction up and down of 3x3 pattern adjacent pointPoint spacing is point space D.Once the spot diameter numerical value R of point S2 to be changed into the spot diameter numerical value R1 of point Sg, it is transitioned into Fig. 7The point spacing of point S1 and point Sg of B be changed to a space D 1.That is, controlling optical scanner 32 etc., so as to aim at light, controlThe point for treating light is regularly arranged according to spacing.Between being further point with the point spacing of the point Sg adjacent point in direction up and downAway from D1.
Here, being illustrated to the irradiation time of the point for the change spot diameter for aiming at light and treatment light.Fig. 8 A-B is shownThe irradiation time of the point S1-S9 of 3x3 pattern, S2 point change the irradiation time of the point Sg after spot diameter.Fig. 8 A shows pre-If 3x3 pattern irradiation time.Fig. 8 B shows the irradiation time after based on the spot diameter for changing point Sg in 3x3 pattern.In the irradiation time for aiming at light, treatment light, the region shown in oblique line is that irradiation aims at light, swashs treatment with what black filledLight.
Fig. 8 A point S2 irradiation time is t.Specifically, the overall exposure time of 3x3 pattern is Tj.Once by the light of point S2Spot diameter numerical value changes into the spot diameter numerical value of point Sg, and the irradiation time for being transitioned into the point Sg of the B of Fig. 8 is changed to t1.ChangeThe point spot diameter of one point, the overall exposure time of 3x3 pattern are accordingly changed to Tj1.That is, being carried out to optical scanner's group 32 equalControl, so as to aim at light, the point for treating laser sorts according to time rule is penetrated.If the overall exposure time T for treating laser isIf a branch of 20ms, laser (state of Fig. 8 A) is treated for 9 prolonged exposures, then substantially 0.2 second.Include in 9 pointsThe Sg point prolonged exposure for changing spot diameter numerical value treats laser (state of Fig. 8 B), and the irradiation time of Sg point is 80ms, then greatlyIt causes to be 0.3 second.Control system 80 does not irradiate aiming light in the irradiation time for the treatment of light.Alternatively, it is also possible in irradiation treatment lightPeriod irradiation aims at light Tm.
In this way, the point spot diameter of the point by setting irradiation patterns, irradiates a series for the treatment of laser.Doctor just canThe position of device will be adjusted by saving a series for the treatment of ends every time, look for and treat the time of next place eyeground treatment region.
It is true to the different affected parts of the eyeground sufferer tissue of same target area by using the primary irradiation position for aiming at lightSurely position and the spot diameter for treating laser, improve the precision for the treatment of.Pass through the point spot diameter of some point of irradiation patternsSetting, for each a series of large-scale continued treatment laser irradiation, doctor can be easy various each in reply treatmentThe case where sample.
The point spot diameter numerical value of the point of irradiation patterns depends on the design of laser switch matrix 50.Refer to that laser is opened hereinThe range of the diameter of the visual field of the output lens of matrix 50 is closed, upper lower limit value is 50-1000um.In addition, in the point of irradiation patternsQueueing discipline in the case of, in irradiation patterns change point spot diameter point quantity cumulative treatment time, be more than treatment swashWithin irradiation time 1 second of light, control system 80 reduces the quantity of point.
In the queueing discipline of the point of irradiation patterns, the setting of the spot diameter numerical value of the point in irradiation patterns is relied onIn the point spacing limit value of a point, the spacing that spacing has been prepared 49 sections by spacing ratio division from 1.25 to 5.0 is put.Predetermined patternSpacing be defined as 2.0, the spot diameter of point is that 100um changes the spot diameter of the point of pattern in this caseThe change range of numerical value, each point can be 50-250 microns.More than the limit value, control system 80 prevents the spot radius of pointChange.In such a case it is possible to change point spacing a little.
Then it to the device of the structure more than having, is illustrated using the therapeutic process of the irradiation for the treatment of laser.DoctorBefore the treatment, project below is set.
(such as 200mW) is set using the output of energy output setting module setting treatment laser, is set using irradiation timeThe pulse width set (such as 20ms) of cover half block sets 3x3 pattern using the presetting module of irradiation patterns setting module, between pointAway from setting module set point space D (2.0), the spot diameter number of 9 points of spot diameter setting module setting 3x3 pattern is utilizedThe setting (50-250um) of value.
Doctor is placed in patient's eye with opticianry lens 2.Also, by operating system 90 to by lighting system 100It is observed on the eyeground of the bright patient's eye of slit illumination.Once doctor's touch control operation system 90 is irradiated the setting of pattern,Then control system 80 starts to aim at the irradiation of light.Doctor observes the 3x3 pattern shown on real-time imaging display unit 93 on one side and showsThe ophthalmoscopic image of aiming light out, carries out the contraposition of destination organization on one side.Once doctor's trigger signal switch 81, control system baseThe irradiation for the treatment of light is carried out in trigger signal.
Thereafter, doctor makes the equal movement of shell 10, repeats above-mentioned movement.It is operated by these, can will treat light prolonged exposureIn full retinal photocoagulation PRP.
In addition, in the above description, after the irradiation treatment light from 1st o'clock to 9th, making the light of target tissue regionThe different structure of solidification spot size refers to, for the matrix pattern of 3x3, to the point irradiation treatment light from initial point to the endMake the photocoagulation spot size of target tissue region different afterwards, but is not limited only to this structure.
In addition in above explanation, the spot diameter of point is set as a point or multiple points, but not limited to this.Diameter is setSurely the arbitrary point that can be in global pattern is ok.In addition, the position of the point of setting is preferably in slit optical range.
In addition, in the above description, the spot diameter of point corresponds to the arrangement of the matrix pattern of 3x3, but notIt is limited to this.It is not necessarily matrix pattern.As long as, can be certainly based on the point for erectting the coordinate system that rectangular central point is originBy, arbitrarily arranged.
In addition, in the above description, in the case where spacing is fixed, the spot diameter of set point, but it is not limited only to this.May not first set point spacing, the spot diameter of the point of pattern in spot diameter upper and lower limits, can be set, between resetting a littleAway from.As a result, point spot diameter confirmation in the case where, cannot corresponding spacing will be skipped or prevent.Thus may be usedSo that the fuel factor of the irradiation position for the treatment of light is dispersed.
In addition, in the above description, it is random it is wavy be defined as the wavy arrangement of paddy under superiors, but not onlyIt is limited to this.A spacing limits are put as long as meeting, enable upper and lower, left and right, inclined direction arrangement a little.
In addition, in the above description, switch matrix device is also used as spot diameter output module, but is not limited only to this.As long as the structure of spot diameter can be changed.
In addition, in the above description, irradiation patterns setting module energy 97a, spot diameter setting module 97b, energy is defeatedSetting module 97c out, irradiation time setting module 97d, parameter setting switch 97e, and thin item switch 97f are not necessarily required's.The setting of device 200 can be preset in a device.
In addition, in the above description, the irradiation for the treatment of light, aiming light is controlled by the optical scanner 51 of switch matrix deviceThe structure of system, but not limited to this.As long as can control the irradiation and non-irradiated to the position of the point of target area.It can makeThe blocking units such as Optic gate.It can also be controlled by the open and close of light source.
In addition, in the above description, seance light is only irradiated to destination organization, but not limited to this.As long as can be intoThe mechanism of row photocoagulation treatment.For example, being repeatedly irradiated in the time as defined in being irradiated in low energy treatment light identicalTarget tissue region.
In addition, in the above description, carrying out photocoagulation treatment although light will be treated and be irradiated in full retinal photocoagulation PRPStructure, but it is not limited only to this.As long as being irradiated in the structure that patient's eye destination organization is treated for light is treated.
It should be noted that not each system (unit) is necessary, for the present invention in above-described embodimentSpeech, the system (unit) that can be realized the object of the invention are just necessary, and above-described embodiment is preferred embodiment, this hairBright protection scope is subject to claims and is recorded.
Although having been presented for several embodiments of the present invention herein, it will be appreciated by those of skill in the art thatWithout departing from the spirit of the invention, the embodiments herein can be changed.Above-described embodiment is only exemplary, noIt should be using the embodiments herein as the restriction of interest field of the present invention.