Background technique
Nose is the start-up portion and olfactory organ of respiration channel, is made of external nose, nasal cavity and 3 part of paranasal sinus, byNasal bone, nasal cartilages, nasalis and coating skin form.Nasal cavity by nasal septum be divided into left and right two chambers, it is preceding there is nostril to communicate with the outside world, afterIt is connected to pharynx nasalis.Nasal cavity interior surface layers are chamber mucous membrane, and surface area is up to 150 cm2, and show there are a large amount of microvillus, underLayer has capillary and capillary lymph duct abundant, is ideal drug administration approach, schneiderian membrance drug-delivery preparation have withUnder advantage:
1. bioavilability is high.Compared with oral administration, nasal-cavity administration can avoid drug and degrade in gastro-intestinal Fluid and liver head mistakeEffect has higher bioavilability, especially suitable for macromolecular polypeptides class drug.Small molecule drug bioavailability is closeIntravenous injection, but with more safety, non-invasive and acceptable.
2. efficiently.There are capillary network abundant in the surface area that schneiderian membrance is beaten again, mucous membrane lower section, and drug can absorb rapidly,A small amount of drug can reach higher blood concentration.
3. drug is avoided to be destroyed by gastrointestinal tract, it is conducive to drug absorption.The drug being easily destroyed in gastrointestinal tract, polarity stomach greatlyEnteron aisle is difficult to the drug absorbed, schneiderian membrance can good absorption, the polypeptide and protein medicaments of macromolecular can also absorbPreferably by Nasal mucosa absorption in the presence of promotor.
4. via intranasal application is administered to intracerebral.Chinese medicine thinks that five key of people communicates, evidence suggests nasal cavities connect with cerebrospinal fluid it is logicalRoad, therefore can orient by schneiderian membrance and be administered to brain tissue.
In addition, nasal cavity is directly communicated with the external world, it is easy also to be susceptible to dust and pollen by various microorganism infectionsEtc. anaphylaxis substance influence, be the high-incidence organ of allergic rhinitis.When nose is sick, often compares and feel bad, it is difficult to it treats, becauseNose areas is reached for drug and needs a very long time, and existing nasal spray therapeutic equipment can only provide high concentration in momentMedical fluid, but the device of drug can be provided for nasal continuous there is presently no a, it is therefore desirable to one kind can continue for a long timeThe device of via intranasal application sustained-release administration reduces the slight illness of people.
Summary of the invention
To solve the above-mentioned problems, the present invention, which provides a kind of nasal cavity slow releasing medicine feeder, to provide medicine for nasal continuousObject mitigates the slight illness of patient's nasal cavity.
The specific technical proposal is: a kind of nasal cavity slow releasing medicine feeder, including fixed frame, reservoir, capillary and contact, instituteIt states reservoir to be arranged on fixed frame, the end of the fixed frame is provided with contact, and the contact is to have the function of certain imbibitionStructure, the reservoir connect by capillary with contact, and reservoir is can be fixed on the bridge of the nose by the fixed frameClip structure.It is provided with medicine feeding hole on the reservoir, is provided with stopple on the medicine feeding hole.
Further, for the fixed mount setting on bridge of the nose top, the fixed frame includes spectacle-frame, spring clip, curved supportFrame and intermediate plate, the spectacle-frame underside are provided with spring clip, and the spring clip is N-shaped, can be suspended on bridge of the nose top；InstituteIt states spring clip lower end and is provided with curved support frame, the curved support frame is upturned；Under the spring clip and curved support frameThe junction at end is provided with intermediate plate, and the intermediate plate tilts upwards, and the intermediate plate has 2 can protrude into nasal cavity；The arc branchSupport upper end is provided with reservoir, and the reservoir has 2, is placed on bridge of the nose top two sides, arc by curved support when useShape support frame can be bent with an iron wire from middle part doubling, and reservoir is clamped on top is fixed on bridge of the nose top, lower end and bulletSpring folder lower end is fixedly connected；Contact is provided with by capillary below the reservoir, the top of intermediate plate is arranged in the contact,The contact has 2, and when use is respectively placed in two nostrils by intermediate plate.The spring clip is N-shaped, primarily to can hangIt hangs over bridge of the nose top and spectacle-frame and fixes entire intranasal medicator together.The curved support frame is to consolidate reservoirIt is scheduled on N-shaped spring clip, and guarantees that reservoir at bridge of the nose position, plays a part of to fix and support.Intermediate plate be in order to support andFixed contact, it is ensured that the deep enough nasal cavity of contact energy guarantees that drug can feed nasal cavity；A kind of branch to tilt upward of intermediate plateSupport, can protrude into nasal cavity for contact, contact contact with nasal wall；Another kind is the structure similar to BB folder or word folder.TouchingHead enters the structure of nasal cavity for the mode that one kind can continue seepage flow.
Further, the reservoir lower wall is provided with silica gel note.
Further, silica gel note edge is silica gel, and centre is provided with sheet metal, the part of wall of the reservoir contacted with sheet metalFace is relatively thin, and convenient for heat transfer, the outer surface of reservoir is using a bit thick rubber, convenient for heat preservation.Sheet metal cannot be too big, too big noseCavity segment is too cool；Can not be too small, too small heat-transfer effect is bad.
Further, the contact is sponge group, cotton mass；Sponge group, cotton mass should be a little bit smaller, can fill in nostrilPlay seepage effect；
Further, it is provided with hook below the spectacle-frame middle section, there is link above the spring clip middle section, the spring clip is logicalCross the connection of link and hook；Spectacle-frame middle section and fixed frame middle section can also be connected with an annulus or filament.
Further, the reservoir is the cryptomere of interior outer double-layer structure, and reservoir is the material for being able to bear 100 DEG C of temperatureIt is made, prevents temperature is excessively high from scorching reservoir；Exothermic material is provided in outer layer blister cavities, liquid medicine is arranged in internal layer blister cavities.StorageLiquid capsule is the cryptomere of interior outer double-layer structure, is provided with exothermic material in outer layer blister cavities, can liquid medicine to internal layer blister cavities intoRow heating, makes when ambient temperature is relatively low, can be heated to drug so that human body is easy to receive.The exothermic material is warmExothermic material is used in baby, is mainly made of materials such as iron powder, activated carbon, vermiculite, water, salt.Heating principle is that iron powder is supported naturallyChange, releases heat.Oxidation of iron powder is that comparison is slow under normal circumstances, and heat can not accumulate, under the action of active powdered carbon, ironPowder and air contact area increase, so producing heat, Yan Heshui is to accelerate oxidation of iron powder, and exothermic material is existingTechnology.
Further, the reservoir outer layer is provided with insulating layer.
Further, the insulating layer is made of organic insulation material or leather substance.
The utility model has the advantages that
1, spectacle-frame and spring clip are flexibly connected, and convenient for the fixation of nose clip, are improved traditional nose clip and are only fixed on nose, nose is difficultBy inaesthetic situation.
2, reservoir can absorb the heat of patient's bridge of the nose part on nose, cool down to bridge of the nose part, make patientIt is more comfortable；Reservoir absorbs the heat of bridge of the nose part, so that the temperature of reservoir and nasal cavity temperature are almost the same, in reservoirLiquid very big stimulation will not be generated when entering nasal cavity, patient is easier to receive.
3, contact is sponge group, cotton mass, convenient for the drug in reservoir slowly, at the uniform velocity, continue into nasal cavity, drug is slowSlow and lasting enters nasal cavity, and therapeutic effect is good.
4, silica gel note edge is silica gel, and centre is provided with sheet metal, the part wall of the reservoir contacted with sheet metal compared withIt is thin, convenient for heat transfer.The outer surface rubber of reservoir is thicker, convenient for heat preservation.
5, reservoir is the cryptomere of interior outer double-layer structure, and the exothermic material being provided in warmer in outer layer blister cavities canIt is heated with the liquid medicine to internal layer blister cavities, makes to heat drug when ambient temperature is relatively low so that human bodyIt is easy to receive.
6, physiological saline alternative medicine can be used in reservoir, be air-dried season and regional (such as Kunming) air for preventingThe dry damage to schneiderian membrance.
Embodiment 1
A kind of nasal cavity slow releasing medicine feeder as shown in Figure 1, the fixed mount setting is at bridge of the nose position, including spectacle-frame 1, springFolder 2, reservoir 3, capillary 4, curved support frame 5, intermediate plate 7 and contact 8,1 underside of spectacle-frame are provided with spring clip 2, instituteStating spring clip 2 is N-shaped；2 lower end of spring clip is provided with curved support frame 5, and the curved support frame 5 is upturned；It is describedThe junction of spring clip 2 and curved support frame 5, which is provided with intermediate plate 7(intermediate plate, 2), the intermediate plate 7 tilts upwards；The arcIt is 2 that 5 upper end of shape support frame, which is provided with reservoir 3(reservoir), contact 8 is provided with by capillary 4 below the reservoir 3(contact has 2), the top of intermediate plate 7 is arranged in the contact 8.3 lower wall of reservoir is provided with silica gel note 6, silica gel noteEdge is silica gel, and centre is provided with sheet metal, and the part wall of the reservoir contacted with sheet metal is relatively thin, the outer surface of reservoirRubber is thicker；The contact 8 is sponge group or cotton mass.Hook, the spring clip are provided with below 1 middle section of spectacle-frameThere is link above 2 middle sections, the spring clip 2 passes through the connection of link and hook.The reservoir is the capsule of interior outer double-layer structureLiquid medicine is arranged in shape, the exothermic material being provided in outer layer blister cavities in warmer, internal layer blister cavities.Intermediate plate 7 is a kind of similarIt is clipped on nose when the piece shape hair clip of elastically deformable, use, makes contact 8 and nasal cavity interior side contacts；When needing to remove contact,Direction effect, sticks up out piece shape hair clip top, takes out convenient for contact.
The medical fluid for needing to input is added when use in reservoir 3, is hanged infusion device by spectacle-frame 1 and spring clip 2Hang over bridge of the nose top, reservoir 3 be placed on by bridge of the nose position by curved support frame 5, intermediate plate 7 by contact 8 protrude into nasal cavity so as toDrug is provided, drug is sent at the contact 8 of nasal cavity by reservoir 3 by capillary 4, and drug is made to protrude into nasal cavity group by nasal wallIn knitting, the purpose for the treatment of is reached.
In summer or the hotter weather in south, reservoir does not need heat supply generally, using single layer reservoir justIt can be the heat around nasal cavity to be reached in reservoir by the sheet metal of silica gel note lower part and is preheated to medical fluid, so that medicineThe body temperature difference of liquid and human body is little, and the nasal cavity of patient is easier to receive.
In winter since temperature is lower, if the medical fluid of input is excessively cool, will increase nose feels bad degree, influences patient'sThe state of mind.At this time with the double-deck blister cavities with self-heating effect, the medical fluid in internal layer blister cavities is suitably heated, then passes throughContact, which enters nasal cavity, keeps patient more comfortable, helps to mitigate illness.And since reservoir has heating function, pass through sheet metalHeat is reached into the bridge of the nose, good adjuvant treatment effect can also be played by keep warm to the bridge of the nose.