CN109498478B - Oil-soluble fullerene topical composition - Google Patents

Abstract

Translated fromChinese

本发明公开了一油溶性富勒烯外用组合物及其制备方法和应用，油溶性富勒烯外用组合物其含有油溶性助剂以及在油溶性助剂中溶解的富勒烯，该组合物具有美容的效果。

The invention discloses an oil-soluble fullerene external use composition and a preparation method and application thereof. The oil-soluble fullerene external use composition contains an oil-soluble auxiliary agent and fullerenes dissolved in the oil-soluble auxiliary agent. The composition Has a cosmetic effect.

Description

Oil-soluble fullerene external composition

Technical Field

The invention relates to the field of daily chemicals, in particular to an external composition with a beautifying effect.

Background

C60 fullerene was discovered by scientists Kroto, Smalley, Curl, et al in 1985 when studying carbon elements deep in space, and three people gained a Nobel prize for chemistry in 1996. Fullerene is an allotrope of carbon, as well as diamond and graphite. C60 is a spherical molecule consisting of 60 carbon atoms, consisting of 12 pentagons and 20 hexagons, each carbon atom and the three adjacent carbon atoms passing through the SP²Hybridized to a bond, known as CITE because it resembles a football. The series of molecules having a cage-like carbon atom cluster structure are collectively referred to as "molecules" and collectively referred to as "caged notes><Cite><Au alkene derivatives, heterocyclic fullerenes, and the like. Common species are C60, C70, C76, C84 and the like.

The fullerene has strong electron accepting capacity due to a large pi bond conjugated system formed by a plurality of P orbitals, has excellent free radical scavenging performance due to unique structure and physicochemical properties, is called as free radical sponge, and simultaneously shows excellent oxidation resistance. So that it has attracted much attention in the fields of cosmetic materials, biomedicines, and the like.

By embedding C60 in the surfactant, C60 can eliminate reactive oxygen species in the cell, inhibit mitochondrial depolarization, activation of cysteine protease, exposure of phosphatidylserine on the cell membrane, and DNA division, and C60 exhibits the effect of protecting cells from oxidative apoptosis. The C60 liposome complex has antioxidant effect by preventing UVA from damaging skin structure, cell nucleus and collagen fiber and permeating into human skin tissue, is 172 times of vitamin C, and has affinity with free radical.

Professor withani withasa long engaged in the study of the properties of C60, as the first person to study fullerene dissolved in olive oil, they found that fullerene had a long life-prolonging health-care function by feeding mice 10-17 months once every two weeks (4 mg fullerene per kg body weight), the control group mice died 17-38 months, and the test group had prolonged life to 59-66 months. No abnormality exists in physiological performance regardless of body weight, and C60 is not found to be toxic or biogenetic, but C60 in a certain amount has the performance of scavenging free radicals, so that animals are protected from harm caused by excessive free radicals.

As external products, fullerene-related products such as C60-PVP have been reported in patents: 200480005008.1, 200580049615.2, because of the limit of the preparation process and the composite property of PVP and C60, in the composite, the content of C60 is not more than 1%, and PVP has obvious film-forming property, and plays a certain role in hindering the exertion of certain cosmetic efficacy after being excessively coated on the surface layer of skin. C60-squalane, application No. 201510427642.4, but C60 has limited solubility in squalane, while squalane is an oil solution, making the use of this series of products limited. The fullerene nanosuspension CN201510971343.7 is a large-particle fullerene component, which affects the stability, appearance and use comfort of the formula after being added into the formula, and the large-particle fullerene component is difficult to repair the skin and can only be attached to the surface layer of the skin to play a barrier role.

Fullerene is a nonpolar molecule with strong hydrophobicity and can only be dissolved in nonpolar organic solvents harmful to living organisms such as toluene, benzene, cyclohexane, chloroform. The hydrophobic property of fullerene directly influences the exertion of the biological activity of the fullerene, and in order to better promote the absorption, the fullerene is prepared into a solution type which is easy to be quickly absorbed by skin and is in a molecular state, and the composition of compounding the fullerene with skin-friendly type has not been researched.

The fullerene-containing composition disclosed by the invention ensures that the fullerene is dispersed in a selected solvent in a molecular state, and the obtained fullerene-containing composition has stable properties and can be used for any external formula. The fullerene in the composition of the present invention is in a dissolved state, and can be used as an ingredient of an external product to better act on the skin.

Disclosure of Invention

The invention aims to provide a fullerene composition, wherein fullerene in the composition is in a dissolved state and is quickly absorbed, and the composition has the effects of whitening, removing freckles, removing wrinkles, resisting acne, preventing alopecia and strengthening hair.

In one aspect, the present invention provides a fullerene composition comprising an oil-soluble adjuvant and a fullerene dissolved or dispersed in the oil-soluble adjuvant.

In one aspect, the invention provides a fullerene dispersion comprising fullerene and an oil-soluble adjuvant, characterised in that more than 50%, such as more than 60%, 70%, 80%, 90%, 95%, 99% of the particle size in the dispersion is less than 5 nm.

In one aspect, the present invention provides a method for preparing a fullerene composition or dispersion, comprising the steps of: taking fullerene powder and an oil-soluble auxiliary agent, uniformly mixing, putting into a high-pressure homogenizer, homogenizing for 1-10 times, preferably 3-8 times, further preferably 5 times at 50-500MPa, preferably 100-300MPa, further preferably 200MPa, then controlling the temperature of the material at 0-25 ℃, preferably 5-20 ℃, further preferably 10-15 ℃, stirring for 1-20h, preferably 5-15h, further preferably 12h, and then centrifuging and/or filtering to obtain the product.

In one aspect, the present invention provides fullerene compositions or dispersions prepared using the methods of the present invention.

According to any one of the preceding aspects, the present invention provides a fullerene composition comprising, in addition to an oil soluble adjuvant and fullerene, at least one antioxidant.

According to any one of the preceding aspects, the present invention provides a fullerene composition comprising, in addition to an oil soluble adjuvant and fullerene, at least one additional active ingredient.

According to any one of the preceding aspects, the invention provides the use of a fullerene composition for the preparation of a cosmetic or toiletry product.

According to any of the preceding aspects, the present invention provides the use of a fullerene composition for the manufacture of a device for cosmetic or cosmetical use.

According to any one of the preceding aspects, the present invention provides a cosmetic method comprising administering to a subject an effective amount of a composition of the invention or an agent comprising a composition of the invention, optionally the cosmetic effect comprises at least one of whitening to remove spots, removing wrinkles, combating acne, preventing hair loss and strengthening hair.

The composition according to the invention may also be used with other adjuvants according to any of the preceding aspects.

According to any of the preceding aspects, the compositions of the present invention may be used together with a surfactant.

According to any of the preceding aspects, the composition of the invention may be incorporated into a cosmetic or drug delivery system and/or a sustained release system.

According to any one of the preceding aspects, the oil soluble adjuvant is selected from: at least one of jojoba oil, caprylic capric triglyceride, isooctyl palmitate, isopropyl palmitate and myristyl myristate, and preferably, the oil-soluble auxiliary agent is at least one of jojoba oil, caprylic capric triglyceride and isooctyl palmitate.

According toIn any of the preceding aspects, the fullerene is one or more of a hollow fullerene, a metal fullerene, a heterocyclic fullerene, and an endohedral fullerene. Including but not limited to fullerene C_2n、M@C_2n、M₂@C_2n、MA@C_2n、M₃N@C_2n、M₂C₂@C_2n、M₂S@C_2n、M₂O@C_2nAnd M_xA_3-xN@C_2nAny one of (1), wherein M and A are both metal elements, and both M and A are selected from any one of Sc, Y and lanthanide metal elements; n is more than or equal to 30 and less than or equal to 60; x is more than or equal to 0 and less than or equal to 3, preferably, the fullerene is any one or a mixture of C60, C70, C76 and C84, Gd @ C82 and derivatives thereof, and further preferably, the fullerene is C60.

The compositions of the present invention may be presented as liquid preparations in the form of, for example, oily suspensions, solutions, or as a dry product for constitution with water or other suitable vehicle before use. Such liquid preparations may contain conventional additives such as suspending agents, for example sorbitol, methyl cellulose, gelatin, hydroxyethyl cellulose, carboxymethyl cellulose, aluminium stearate gel or hydrogenated edible fats; solutions are generally prepared by dissolving the active substance in a carrier and filter sterilizing and then sealing it before filling it in a suitable vial or ampoule.

In one aspect, the invention provides a method for preparing an aqueous solution from a fullerene composition, comprising the following steps: mixing the fullerene composition with water according to a ratio, stirring uniformly, then homogenizing, and adding a preservative and essence to obtain a water aqua.

The composition of the present invention is prepared in the form of an emulsion, and may contain conventional emulsifiers, co-emulsions, surfactants, and the like.

In one aspect, the present invention provides a method of preparing an emulsion of a fullerene composition: mixing the fullerene composition with an emulsifier according to a ratio, homogenizing to form an emulsion or paste, and adding a preservative and an essence to obtain the emulsion.

In one aspect, the present invention provides the use of a composition or dispersion of the invention in the preparation of a cosmetic or toiletry product.

In one aspect, the present invention provides the use of a composition or dispersion of the invention in the preparation of a device for cosmetic or toiletry use.

According to any one of the preceding aspects, the cosmetic or toiletry product is used for whitening, removing freckles, removing wrinkles, resisting acne, preventing haze, growing hair, fixing hair and the like.

Drawings

FIG. 1: and (5) electron microscope experiment results.

FIG. 2: acne treatment experiment.

FIG. 3: quantitative result of acne removing experiment.

FIG. 4: and (5) a whitening experiment result.

FIG. 5: haze prevention test results.

Detailed Description

The following detailed description of the present invention is provided in conjunction with the accompanying drawings, but it should be understood that the scope of the present invention is not limited to the specific embodiments.

Throughout the specification and claims, unless explicitly stated otherwise, the word "comprise", or variations such as "comprises" or "comprising", will be understood to imply the inclusion of a stated element or component but not the exclusion of any other element or component.

In one embodiment, the present invention provides a fullerene composition comprising an oil soluble adjuvant and fullerenes dissolved or dispersed in the oil soluble adjuvant, optionally at a fullerene concentration of 0.01 to 5mg/ml, preferably 0.05 to 3mg/ml, more preferably 0.1 to 2mg/ml, even more preferably 1 mg/ml.

In one embodiment, the present invention provides a fullerene dispersion comprising fullerene and an oil-soluble auxiliary agent, wherein 50% or more, such as 60%, 70%, 80%, 90%, 95%, 99% or more, of the particle size in the dispersion is less than 5 nm.

In one embodiment, the present invention provides a method of preparing a fullerene composition or dispersion, comprising the steps of: taking fullerene powder and an oil-soluble auxiliary agent, uniformly mixing, putting into a high-pressure homogenizer, homogenizing for 1-10 times, preferably 3-8 times, further preferably 5 times at 50-500MPa, preferably 100-300MPa, further preferably 200MPa, then controlling the temperature of the material at 0-25 ℃, preferably 5-20 ℃, further preferably 10-15 ℃, stirring for 1-20h, preferably 5-15h, further preferably 12h, and then centrifuging and/or filtering to obtain the product.

In one embodiment, the present invention provides a fullerene composition comprising, in addition to an oil soluble adjuvant and fullerene, at least one antioxidant selected from at least one of superoxide dismutase, mannitol, histidine, tryptophan, bilirubin, quercetin, polyphenols, procyanidins, tocotrienols, catechins, catechin derivatives, rutin and derivatives thereof, gallic acid and derivatives thereof, ubiquinone, astaxanthin, carotene, and other carotenoids and derivatives and salts thereof, vitamin B and derivatives and salts thereof, vitamin D and derivatives and salts thereof, vitamin E and derivatives and salts thereof, dibutylhydroxytoluene, and butylhydroxyanisole.

In one embodiment, the present invention provides a fullerene composition comprising, in addition to an oil soluble adjuvant and fullerenes, at least one additional active ingredient including, but not limited to: matrix metalloelastase inhibitors, melanin synthesis stimulators or inhibitors, whitening or depigmenting agents, pro-pigmenting agents, sunless tanning agents, anti-ageing agents, NO-synthase inhibitors, antioxidants, radical scavengers and/or anti-atmospheric agents, anti-glycation agents, emulsifiers, emollients, organic solvents, liquid propellants, skin conditioning agents such as humectants, moisture retaining substances, alpha hydroxy acids, beta hydroxy acids, moisturizers, epidermal hydrolases, vitamins, pigments or colorants, dyes, gel polymers, thickeners, surfactants, emollients, anti-wrinkle agents, agents capable of reducing or treating bags under the eye, exfoliants, antimicrobial agents, fungicides, fungistats, bactericides, bacteriostats, dermal or epidermal macromolecular synthesis stimulators and/or agents capable of preventing or inhibiting dermal or epidermal macromolecular degradation, collagen synthesis stimulators, elastin synthesis stimulators, decorin synthesis stimulators, laminin synthesis stimulators, defensin synthesis stimulators, chaperone synthesis stimulators, aquaporin synthesis stimulators, hyaluronic acid synthesis stimulators, component synthesis stimulators of lipids and the stratum corneum, ceramide synthesis stimulators, collagen degradation inhibitors, elastin degradation inhibitors, fibroblast proliferation stimulators, keratinocyte proliferation stimulators, adipocyte proliferation stimulators, melanocyte proliferation stimulators, keratinocyte differentiation stimulators, adipocyte differentiation stimulators, acetylcholinesterase inhibitors, skin relaxants, glycosaminoglycan synthesis stimulators, DNA repair agents, DNA protection agents, antipruritics, agents for the treatment and/or care of sensitive skin, firming agents, anti-stretch mark agents, astringents, agents regulating sebum production, lipolytic stimulators, anti-cellulitis agents, healing stimulators, healing auxiliary adjuvants, re-epithelialization stimulators, re-epithelialization auxiliary adjuvants, cytokine growth factors, sedatives, anti-inflammatory agents, agents acting on the capillary circulation and/or microcirculation, angiogenesis stimulators, vascular permeability inhibitors, agents acting on cell metabolism, agents for improving dermal-epidermal junction, agents for promoting hair growth, agents for inhibiting or retarding hair growth, preservatives, fragrances, chelating agents, plant extracts, essential oils, marine extracts, agents from biofermentation processes, mineral salts, cell extracts and sunscreens (organic or mineral photoprotective agents acting against uv a and/or uv B), or mixtures thereof.

In one embodiment, the invention provides the use of a fullerene composition for the preparation of a cosmetic or toiletry product.

In one embodiment, the cosmetic or toiletry dosage form includes, but is not limited to, any of a solution, suspension, emulsion, ointment, gel, cream, emulsion, powder, soap, surfactant-containing cleanser, oil, powder foundation, emulsion, foundation, wax foundation, spray, liniment, paste, and poultice, such as a cream, multiple emulsion, anhydrous composition, aqueous dispersion, oil, emulsion, balm, foam, lotion, gel, cream gel, hydroalcoholic solution, hydroglycolic solution, liniment, saline solution, soap, shampoo, conditioner, slurry, ointment, mousse, ointment, powder, stick, pen, spray, aerosol, capsule, gelatin capsule, tablet, coated tablet, powder, granular form, chewing gum, solution, suspension, emulsion, syrup, polysaccharide film, jelly, gel, cream, lotion, gel, cream, ointment, or poultice, Gelatin, ointments, creams, softening lotions, nourishing lotions, masks, essences, hair tonics, shampoos, rinses, conditioners, hair conditioners, gels, skin lotions, skin softeners, fresheners, astringents, lotions, milk lotions, moisturizing lotions, nourishing lotions, massage creams, nourishing creams, moisturizing creams, hand creams, foundation creams, nourishing essences, sunscreen creams, soaps, cleansing foams, cleansing milks, cleansing creams, body lotions, and body cleansers, under-eye removers, cosmetic foundations, make-up remover lotions, eye shadows, lipstick, lip gloss, and lip powder; the effects of the cosmetic or toiletry product include, but are not limited to: whitening skin, improving pigmentation, treating acne, improving wrinkle, improving pachylosis, improving oily skin, improving dry skin, shrinking pore, treating scar, treating flush complexion, treating alopecia, promoting hair growth, treating burn, killing bacteria and mite, improving skin pit, and preventing acne and haze.

In one embodiment, the present invention provides the use of a fullerene composition for the preparation of a device for cosmetic or cosmetical use, including, but not limited to, antiseptic wipes, antiseptic cotton sticks, antiseptic packs, medical dressing wipes, lotions, rinses, dressings, liquid dressings, bandages; the application may be the attachment of the compositions of the present invention to specific materials including, but not limited to: cotton swabs, wet tissues, towels, tissues, gauze, cotton sticks, non-woven fabrics, high polymer materials, medical dressings, plastic models non-stick gauze, vaseline oil gauze, semi-permeable films, foam accessories and the like.

In one embodiment, the composition of the present invention may also be used with other adjuvants including hyaluronic acid, fats and oils, surfactants, preservatives, fragrances, binders, thickeners, complexing agents, PH adjusters.

In one embodiment, the compositions of the present invention may be used with a surfactant selected from the group consisting of: at least one of anionic surfactant, cationic surfactant, amphoteric surfactant, lipophilic nonionic surfactant, hydrophilic nonionic surfactant, and natural surfactant.

In one embodiment, examples of the anionic surfactant include soap raw materials, fatty acid soaps such as sodium laurate and sodium palmitate, higher alkyl sulfate salts such as sodium lauryl sulfate and potassium lauryl sulfate, alkyl ether sulfate salts such as Polyoxyethylene (POE) -triethanolamine lauryl sulfate and POE-sodium lauryl sulfate, N-acyl sarcosine such as sodium lauroyl sarcosinate, higher fatty acid amide sulfonates such as sodium N-myristoyl-N-methyltaurate, sodium coconut fatty acid methyltaurate and sodium lauryl methyltaurate, phosphate salts such as POE-oleyl ether sodium phosphate and POE-stearyl ether phosphoric acid, sulfosuccinates such as sodium di-2-ethylhexyl sulfosuccinate, sodium monolauroyl monoethanolamide polyoxyethylene sulfosuccinate and sodium lauryl polypropylene glycol sulfosuccinate, alkyl benzene sulfonate such as linear dodecyl benzene sulfonate, linear dodecyl benzene sulfonate triethanolamine, and linear dodecyl benzene sulfonate, N-acyl glutamate such as monosodium N-lauroyl glutamate, disodium N-stearoyl glutamate, and monosodium N-myristoyl-L-glutamate, higher fatty acid ester sulfate such as hardened coconut oil fatty acid sodium glycerosulfate, sulfated oil such as turkey red oil, and at least one of POE-alkyl ether carboxylic acid, POE-alkyl allyl ether carboxylate, alpha-olefin sulfonate, higher fatty acid ester sulfonate, secondary alcohol sulfate, higher fatty acid alkylolamide sulfate, lauroyl monoethanolamide sodium succinate, N-palmitoyl aspartic acid ditriethanolamine, and sodium caseinate.

In one embodiment, the cationic surfactant includes at least one of alkyltrimethylammonium salts such as stearyltrimethylammonium chloride and lauryltrimethylammonium chloride, dialkyldimethylammonium chloride, alkylpyridinium salts such as poly (N, N' -dimethyl-3, 5-methylenepiperidinium) chloride and cetylpyridinium chloride, and alkyl quaternary ammonium salts, alkyldimethylbenzylammonium salts, alkylisoquinolinium salts, dialkylmorpholinium salts, POE-alkylamines, alkylamine salts, polyamine fatty acid derivatives, pentanol fatty acid derivatives, benzalkonium chloride and benzethonium chloride.

In one embodiment, the amphoteric surfactant includes at least one of imidazoline-based amphoteric surfactants such as 2-undecyl-N, N, N- (hydroxyethylcarboxymethyl) -2-imidazoline sodium and 2-coco-2-imidazoline hydroxide-1-carboxyethoxy disodium salt, and betaine-based amphoteric surfactants such as 2-heptadecyl-N-carboxymethyl-N-hydroxyethylimidazolinium betaine, lauryl dimethylaminoacetic acid betaine, alkyl betaine, amidobetaine, and sulfobetaine.

In one embodiment, examples of the lipophilic nonionic surfactant include sorbitan fatty acid esters such as sorbitan monooleate, sorbitan monoisostearate, sorbitan monolaurate, sorbitan monopalmitate, sorbitan monostearate, sorbitan sesquioleate, sorbitan trioleate, diglycerol penta-2-ethylhexanoate sorbitan, diglycerol tetra-2-ethylhexanoate sorbitan, fatty acid glycerides such as cottonseed oil fatty acid glyceride, glycerol monooleate, glycerol sesquioleate, glycerol monostearate, α' -oleic acid pyroglutamic acid glyceride, glycerol monostearate and polyglyceryl fatty acid esters such as glycerol monoisostearate and glycerol diisostearate, propylene glycol fatty acid esters such as propylene glycol monostearate, hardened castor oil derivatives, and glycerin alkyl ether.

In one embodiment, examples of the hydrophilic nonionic surfactant include POE-sorbitan fatty acid esters such as POE-sorbitan monooleate, POE-sorbitan monostearate, POE-sorbitan monooleate, POE-sorbitan tetraoleate, POE-sorbitol fatty acid esters such as POE-sorbitol monolaurate, POE-sorbitol monooleate, POE-sorbitol pentaoleate, and POE-sorbitol monostearate, POE-glycerin fatty acid esters such as POE-glycerin monostearate, POE-glycerin monoisostearate, and POE-glycerin triisostearate, POE-glycerin fatty acid esters such as POE-monooleate, POE-distearate, POE-monodioleate, and ethylene glycol distearate, POE-alkyl ethers such as POE-lauryl ether, POE-oleyl ether, POE-stearyl ether, POE-behenyl ether, POE-2-octyldodecyl ether and POE-cholestanyl alcohol ether, Pluronic types such as Pluronic (addition polymer of polypropylene glycol and ethylene oxide), POE-POP-cetyl ether, POE-POP-2-decyltetradecyl ether, POE-POP-monobutyl ether, POE-POP-hydrogenated lanolin, POE-POP-alkyl ethers such as POE-POP-glyceryl ether, POE-castor oil, POE-hardened castor oil monoisostearate, POE-hardened castor oil triisostearate, POE-hardened castor oil monopyroglutamic acid monoisostearate, POE-hardened castor oil maleic acid and other POE-hardened castor oil derivatives, POE-beeswax and lanolin derivatives such as POE-sorbitol beeswax, alkanolamides such as coconut oil fatty acid diethanolamide, lauric acid monoethanolamide, and fatty acid isopropanolamide, and at least one of POE-propylene glycol fatty acid esters, POE-alkylamine, POE-fatty acid amides, sucrose fatty acid esters, POE-nonylphenyl formaldehyde condensates, alkyl ethoxy dimethyl amine oxide, and triolenylphosphoric acid.

In one embodiment, the natural surfactant includes at least one of soybean phospholipids, hydrogenated soybean phospholipids, egg yolk phospholipids, hydrogenated egg yolk phospholipids, soybean saporin, and other lecithins.

In one embodiment, the composition of the present invention may be incorporated into a cosmetic or drug delivery system and/or a sustained release system selected from the group consisting of: liposomes, mixed liposomes, millimeter microcapsules, nanocapsules, sponges, cyclodextrins, vesicles, micelles, surfactant-mixed micelles, phospholipid-surfactant-mixed micelles, millimeter microspheres, nanospheres, lipid microspheres, microemulsions, nanoemulsions, millimeter particles, microparticles, nanoparticles, and solid lipid nanoparticles.

In one embodiment, the oily auxiliary may be selected from at least one of liquid oils and fats, solid oils and fats, waxes, hydrocarbon oils, higher fatty acids, higher alcohols, ester oils, silicone oils.

In one embodiment, as the liquid oil and fat, for example, at least one of avocado oil, camellia oil, turtle oil, macadamia nut oil, corn oil, sunflower oil, mink oil, olive oil, rapeseed oil, egg yolk oil, sesame oil, almond oil, wheat germ oil, camellia oil, castor oil, linseed oil, safflower oil, grapeseed oil, cottonseed oil, perilla oil, soybean oil, peanut oil, tea seed oil, coconut oil, rice bran oil, paulownia oil, jatropha oil, jojoba oil, germ oil, evening primrose oil, glyceryl trioctanoate, glyceryl trioctate, and the like can be cited. Here, the liquid fat refers to a fat that is liquid at room temperature.

In one embodiment, as the solid fat, for example, at least one of cocoa butter, coconut oil, beef tallow, mutton tallow, horse tallow, palm kernel oil, lard, beef bone fat, wax oil, neatsfoot oil, resin wax, hardened coconut oil, hardened palm oil, hardened beef tallow, hardened oil, and hardened castor oil, and the like can be cited.

In one embodiment, the wax may be at least one of beeswax, candelilla wax, cotton wax, carnauba wax, bayberry wax, insect wax, spermaceti wax, montan wax, rice bran wax, kapok wax, sugar cane wax, lanolin acetate, liquid lanolin, isopropyl lanolin fatty acid ester, reduced lanolin, hard lanolin, hexyl laurate, jojoba wax, shellac wax, POE lanolin alcohol ether, POE lanolin alcohol acetate, POE cholesterol ether, lanolin fatty acid polyethylene glycol, POE hydrogenated lanolin alcohol ether, and the like.

In one embodiment, the hydrocarbon oil includes at least one of liquid paraffin, isoparaffin, heavy liquid isoparaffin, paraffin, ozokerite, squalane, vegetable squalane, pristane, ceresin, squalene, vaseline, microcrystalline wax, paraffin, montan wax, olefin oligomer, polyisobutylene, polybutene, and hydrogenated polybutene.

In one embodiment, as the higher fatty acid, for example, at least one of lauric acid, myristic acid, palmitic acid, stearic acid, behenic acid (Behenicacid), oleic acid, undecylenic acid, tall oil acid, isostearic acid, linoleic acid, linolenic acid, eicosapentaenoic acid (EPA), and docosahexaenoic acid (DHA) and the like can be cited.

In one embodiment, the higher alcohol includes at least one of a linear alcohol such as lauryl alcohol, cetyl alcohol, stearyl alcohol, behenyl alcohol, myristyl alcohol, oleyl alcohol, and cetostearyl alcohol, and a branched alcohol such as monostearyl glyceryl ether (batyl alcohol), 2-decyltetradecyl alcohol, lanolin alcohol, cholesterol, phytosterol, hexyldodecanol, isostearyl alcohol, and octyldodecanol.

In one embodiment, as the ester oil, for example, isopropyl myristate, cetyl isooctanoate, octyldodecyl myristate, isopropyl palmitate, isooctyl palmitate, butyl stearate, hexyl laurate, myristyl myristate, decyl oleate, caprylic/capric triglyceride, hexyldecyl dimethyl octanoate, cetyl lactate, myristyl lactate, octyldodecyl lactate, lanolin acetate, isocetyl stearate, isocetyl isostearate, cholesterol 12-hydroxystearate, phytosterol oleate, ethylene glycol di-2-ethylhexanoate, propylene glycol dicaprate, dipentaerythritol fatty acid ester, N-alkyl glycol monoisostearate, neopentyl glycol dicaprate, diisostearyl malate, diisoglyceryl di-2-heptylundecylate, ethylene glycol dicaprate, propylene glycol dicaprate, and the like, Trimethylolpropane tri-2-ethylhexanoate, trimethylolpropane triisostearate, pentaerythritol tetra-2-ethylhexanoate, glycerol tri (decanoyl) ester, glycerol tri (decanoyl tricaprin) ester, glycerol trimyristate stearate, trimethylolpropane triisostearate, cetyl 2-ethylhexanoate, 2-ethylhexyl palmitate, glycerol trimyristate, glycerol tri-2-heptyl undecanoate, polyglycerol diisostearate, polyglycerol triisostearate, polyglycerol tetraisostearate, diglycerol triisostearate, diglycerol tetraisostearate, diglycerol triisostearate, erythritol tri-2-ethylhexanoate, ditrimethylolpropane tri-2-ethylhexanoate, trimethylolpropane tri-2-ethylhexanoate, glycerol tetraisostearate, glycerol hexa-stearate, glycerol hexa-2-oleate, glycerol hexa-2, Ditrimethylolpropane oligoester (isostearic acid/sebacic acid), methyl ricinoleate, oleyl oleate, glyceryl acetate, 2-heptylundecyl palmitate, diisobutyl adipate, glyceryl oligoester (adipate 2-ethylhexanoate stearic acid), diglyceryl oligoester (2-hexyldecanoate sebacic acid), N-lauroyl-L-glutamic acid 2-octyldodecyl ester, di-2-heptylundecyl adipate, at least one of ethyl laurate, di-2-ethylhexyl sebacate, 2-hexyldecyl myristate, 2-hexyldecyl palmitate, 2-hexyldecyl adipate, diisopropyl sebacate, 2-ethylhexyl succinate, ethyl acetate, butyl acetate, triethyl citrate, and the like.

In one embodiment, the silicone oil includes at least one of chain polysiloxanes such as dimethylpolysiloxane, methylphenylpolysiloxane, and methylhydrogenpolysiloxane, cyclic polysiloxanes such as octamethylcyclotetrasiloxane, decamethylcyclopentasiloxane, dodecamethylcyclohexasiloxane, and tetramethyltetrahydrocyclotetrasiloxane, and polyoxyethylene polyalkylsiloxane.

In one embodiment, the oil soluble adjuvant is selected from the group consisting of: at least one of jojoba oil, meadowfoam seed oil, caprylic/capric triglyceride, isooctyl palmitate, isopropyl palmitate and myristyl myristate, and preferably, the oil-soluble auxiliary agent is at least one of jojoba oil, caprylic/capric triglyceride and isooctyl palmitate.

In one embodiment, the oil-soluble auxiliary agent comprises jojoba oil, meadowfoam seed oil, caprylic capric triglyceride and isooctyl palmitate, and the mass ratio of the jojoba oil to the meadowfoam seed oil is (1-7): (1-7): (1-7), for example, 4:3:2:1, 3:2:4:1, 2:1:6:1, 3:1:3, 2:1:5, 1:7, preferably 4:3:2: 1.

In one embodiment, the fullerene is one or more of an empty fullerene, a metallic fullerene, a heterocyclic fullerene, and an endohedral fullerene. Including but not limited to fullerene C_2n、M@C_2n、M₂@C_2n、MA@C_2n、M₃N@C_2n、M₂C₂@C_2n、M₂S@C_2n、M₂O@C_2nAnd M_xA_3-xN@C_2nAny one of (1), wherein M and A are both metal elements, and both M and A are selected from any one of Sc, Y and lanthanide metal elements; n is more than or equal to 30 and less than or equal to 60; x is more than or equal to 0 and less than or equal to 3, preferably, the fullerene is any one or a mixture of C60, C70, C76 and C84, Gd @ C82 and derivatives thereof, and further preferably, the fullerene is C60.

In one embodiment, the compositions of the present invention are in the form of a liquid formulation, such as an oily suspension, a solution, or a dry product which may be reconstituted with water or other suitable carrier prior to use. Such liquid preparations may contain conventional additives such as suspending agents, for example sorbitol, methyl cellulose, gelatin, hydroxyethyl cellulose, carboxymethyl cellulose, aluminium stearate gel or hydrogenated edible fats; solutions are generally prepared by dissolving the active substance in a carrier and filter sterilizing and then sealing it before filling it in a suitable vial or ampoule.

In one embodiment, the invention provides a method for preparing a fullerene composition into an aqueous solution, which comprises the following steps: the fullerene composition is mixed with water according to a ratio, then is uniformly stirred and is well homogenized, and a preservative and essence are added to obtain the aqueous solution.

In one embodiment, the compositions of the present invention are prepared in the form of emulsions, which may contain conventional emulsifiers, co-emulsions, surfactants, and the like.

In one embodiment, the present invention provides a method of preparing an emulsion of a fullerene composition comprising: the fullerene composition is mixed with an emulsifier according to a ratio, then homogenized to form emulsion or paste, and added with a preservative and essence to obtain the emulsion.

In one embodiment, the present invention provides the use of a composition or dispersion of the present invention in the preparation of a cosmetic or toiletry product.

In one embodiment, the present invention provides the use of a composition or dispersion of the present invention in the preparation of a device for cosmetic or toiletry use.

Examples

The invention is further illustrated below with reference to examples. The description of the specific exemplary embodiments of the present invention has been presented for purposes of illustration and description. It is not intended to limit the invention to the precise form disclosed, and obviously, many modifications and variations are possible in light of the teaching of this specification. The exemplary embodiments were chosen and described in order to explain certain principles of the invention and its practical application to enable one skilled in the art to make and use various exemplary embodiments of the invention and various alternatives and modifications as are suited to the particular use contemplated.

Example 1:

taking fullerene powder and an oil-soluble auxiliary agent, uniformly mixing the mixture, putting the mixture into a micro-jet high-pressure homogenizer, homogenizing for 5 times under 200MPa, controlling the temperature of the materials at 15 ℃, stirring for 12 hours, and carrying out centrifugal filtration to obtain the composition.

The state of the fullerene composition is observed by a transmission electron microscope, and no particulate matter is detected at 250000 times of magnification, which indicates that the fullerene is dissolved in the auxiliary material, and the result is shown in fig. 1.

Example 2:

anti-wrinkle firming eye cream

Example 3:

anti-wrinkle skin-brightening cream

Example 4:

hair loss preventing and hair strengthening shampoo

Example 5: skin transmittance test

Fullerene compositions according to the invention were prepared as in example 1.

Control group: application No.: 200480005008.1 example 1 discloses micelle coated fullerene complexes.

The experimental method comprises the following steps: the skin of the suckling pig is selected as an experimental object, and the fullerene composition (jojoba oil, caprylic/capric triglyceride and isooctyl palmitate are 4:5:1) and the fullerene compound coated by the micelle are subjected to transdermal experimental comparison respectively. And (4) performing drug transmittance analysis by using LC-MS.

The results show that: after 6 hours, the fullerene composition has a transmittance of 80%, and the micelle-coated complex has a transmittance of only 20%.

And (4) conclusion: the composition containing fullerene is bright purple, wherein the fullerene is in a dissolved state, and the obtained composition containing fullerene has stable property, can be used for any external formula, is very easy to permeate through the stratum corneum of skin, is easier to absorb and utilize, and has more easily exerted efficacy.

Example 6: preparation of oil-soluble auxiliary agent

Taking fullerene powder and an oil-soluble auxiliary agent, uniformly mixing the mixture, putting the mixture into a micro-jet high-pressure homogenizer, homogenizing for 5 times under 200MPa, controlling the temperature of the materials at 15 ℃, stirring for 12 hours, and carrying out centrifugal filtration to obtain the composition.

Solubility of fullerenes in a single adjuvant

The liquid phase is calibrated, wherein the content of the fullerene is 1mg/ml, which shows that the fullerene is effectively dissolved in the oil-soluble auxiliary agent with the proportion.

Jojoba oil is a vegetable oil, and although it is much more stable than other vegetable oils such as olive oil and linseed oil, there is still some instability of the oil. The meadowfoam seed oil is antioxidant grease, is more stable and has cleaner and more moist skin. Caprylic capric triglyceride: a highly clean, odorless oil is a derivative of palm oil or coconut oil, and is extracted by thermal fractionation. It has a non-greasy texture due to its characteristic of compatibility with human skin, and can be added to a cream or lotion to improve its extensibility, and has lubricating and skin softening effects. It has ultraviolet filtering function, and can be used as extract of coconut and emollient and solvent in cosmetics. Isooctyl palmitate: has certain transdermal property and mild property. The composition with different proportions is comprehensively inspected, and the jojoba oil is found to be: white Potentilla seed oil: caprylic capric triglyceride: isooctyl palmitate 4:3:2:1, the composition has better stability, optimal skin absorbability and milder skin feel.

Example 7: whitening and freckle removing effects

The experimental method comprises the following steps: after anesthetizing the mice with 2.5% sodium pentobarbital, the model group was injected 6 times a week for 4 consecutive weeks with 0.4% progesterone injection at a dose of 0.02g/kg of mouse hindlimb muscle. The normal group was injected intramuscularly with sterile water for injection at 0.02 g/kg. Healthy female mice were taken as 60, 3 dose groups, and randomly divided into 6 groups of 10 mice each. A normal group, a model group, a group of fullerene compositions (where jojoba oil: meadowfoam oil: caprylic capric triglyceride: isooctyl palmitate is 4:3:2: 1) for external application of 3 dose groups (0.10, 0.20, 0.40mg/ml), a 3% hydroquinone positive control group (0.69 mg/ml). A group of 3 dose treatment groups are externally applied to the skin of a mouse on the day of model building, 1 time per day and 30 days of continuous application. The normal group and the model group were given a local application of distilled water at the corresponding times; the 3% hydroquinone positive drug control group is applied topically on the same day as the fullerene group. After 30 days of administration, mice are killed by dislocation of cervical vertebrae, hair is removed from the back, 2 blocks of liver tissue and skin tissue of the drug-coated part are taken out rapidly, one block is washed by ice-cold normal saline, blood is removed, filter paper is sucked dry, 0.5g of liver and skin are cut out respectively, the liver and the skin are put into 2.0ml of beakers of precooled normal saline respectively, tissues are cut into pieces, then the cut pieces are poured into a test tube, and the test tube is homogenized twice by a high-speed disperser l0r/min for 10 seconds each time; then, the mixture is centrifuged at 3500r/rain for 15 minutes, and the supernatant is taken and tested.

As a result: as shown in Table 2 below

TABLE 2

And (4) conclusion: as shown in table 2 above, the normal group was unmolded, the model group was drug-treated after molding, and the positive group was hydroquinone known to have an excellent whitening effect. After the model is successfully made, the number of melanocytes of the model group is obviously increased, the number of dermal inflammatory cells is increased, the number of dermal blood vessels is reduced, and the comparison of the low, medium and high administration groups shows that the number of melanocytes and dermal inflammatory cells is lower than that of the model group, and the number of dermal blood vessels is obviously increased, which indicates that the skin whitening effect is certain and a certain concentration dependence relationship exists. The composition has obvious effects on a model group and a positive control group, and has the effects of whitening and removing freckles.

Example 8: anti-oxidation wrinkle-removing agent

The experimental method comprises the following steps: the experiment group is divided into two groups of 10 nude mice with 6 weeks, the back of the right side ear of the nude mice is coated with oil-soluble fullerene composition (wherein jojoba oil: white chingma oil: caprylic capric triglyceride: isooctyl palmitate is 4:3:2: 1), the dose is about 0.5g twice a day, and the control group is not administrated. Feeding with the same feed at room temperature of 22 + -2 deg.C under clean, ventilated and dry conditions. After 60 days, 8 patients are taken out respectively, and the affected part of the cervical vertebra and the skin of the corresponding part on the opposite side are taken for detection after the dislocation of the cervical vertebra is dead. The effect of the water-soluble fullerene external-use composition on the proportion of skin collagen in the area of the dermis layer in the 60-day experimental group is observed.

As a result: as shown in Table 3, the composition of the present invention had a significant effect on the increase of collagen in the dermis after 60 days.

TABLE 3 influence of oil-soluble fullerene external composition on ratio of skin collagen to dermis layer area

Example 9: evaluation of human body external effect by using fullerene composition formula

The composition is added into conventional emulsion to prepare new emulsion product.

Acne removal experiments: gender was randomized, 20 subjects aged 18-55 years with mild, moderate and severe acne on the face, using the product for 14 days, with results shown in figures 2 and 3.

Thin line fading experiment: 20 women of 35-55 years old with obvious wrinkles in canthus, and the product is used for 30 days

Skin color improvement experiment: 20 women of 35-55 years old with dark complexion are continuously used for 4 weeks in the morning and evening respectively with a cream containing 3% of fullerene of the present composition. Data were obtained by questionnaire and photographic analysis. It can be seen that the cream added with 3% of fullerene has obvious effects of brightening skin and whitening skin. The results are shown in FIG. 4

Spot-fading experiments: 20 women of 35-55 years old with light brown patches on their local surface, and the product is administered for 30 days

Hair-fixing and anti-dropping experiment: people suffering from alopecia have unlimited properties, and the product is used for 30 days

Prevent haze effect: the fullerene composition of this patent (where jojoba oil: meadowfoam oil: caprylic capric triglyceride: isooctyl palmitate is 4:3:2: 1) was treated on skin explants for 5 days and then exposed to a contaminated environment. The results show that the state of skin cells treated with the composition of this patent is almost the same as that of the blank group. The haze-damaged skin showed a significant increase in damaged cells, and the results are shown in fig. 5.

As a result:

group of	Acne removing device	Variation of fine lines	Skin color improvement	Speckle reduction	Hair-fixing and anti-dropping device
							80％	65％	70％	50％	60％

And (4) conclusion: the fullerene composition has the effects of beautifying, removing acnes, eliminating fine lines and improving skin color and spot fading.

The invention has the beneficial effects that

1. The fullerene in the fullerene-containing composition is in a molecular state, has small particle size, and is easy to release in a formula and further absorbed and utilized.

2. The preparation method of the composition containing fullerene is simple and easy to implement, and is suitable for mass preparation.

3. The fullerene containing composition of the present invention is stable in properties and suitable for the preparation of any external formulation.

4. The composition containing fullerene has the functions of whitening, removing freckles and removing wrinkles.

Claims (46)

Translated fromChinese

1.一种富勒烯组合物，其含有油溶性助剂以及在油溶性助剂中溶解或分散的富勒烯，所述油溶性助剂包括荷荷芭油、白池花籽油、辛酸癸酸甘油三酯和棕榈酸异辛酯。1. a kind of fullerene composition, it contains oil-soluble auxiliary agent and the fullerene that is dissolved or dispersed in oil-soluble auxiliary agent, and described oil-soluble auxiliary agent comprises jojoba oil, white chia seed oil, caprylic acid decyl acid triglycerides and isooctyl palmitate.2.根据权利要求1所述的组合物，其中，除了油溶性助剂和富勒烯之外，还含有至少一种抗氧化剂。2. The composition according to claim 1, which contains at least one antioxidant in addition to the oil-soluble adjuvant and fullerene.3.根据权利要求1所述的组合物，其中，除了油溶性助剂和富勒烯之外，还含有至少一种另外的活性成分。3. The composition of claim 1 , which, in addition to the oil-soluble adjuvant and fullerenes, contains at least one further active ingredient.4.根据权利要求1所述的组合物，其中，所述组合物加入到化妆品或药物递送系统和/或缓释系统中。4. The composition of claim 1, wherein the composition is incorporated into a cosmetic or drug delivery system and/or a sustained release system.5.根据权利要求1-4任一项的组合物，其中，所述油溶性助剂为荷荷巴油、白池花籽油、辛酸癸酸甘油三酯和棕榈酸异辛酯，其质量配比为(1-7)：(1-7)：(1-7)：(1-7)。5. The composition according to any one of claims 1-4, wherein the oil-soluble adjuvant is jojoba oil, white chia seed oil, caprylic capric triglyceride and isooctyl palmitate, the quality of which is equal to The ratio is (1-7):(1-7):(1-7):(1-7).6.根据权利要求5所述的组合物，其中，所述油溶性助剂为荷荷巴油、白池花籽油、辛酸癸酸甘油三酯和棕榈酸异辛酯，其质量配比为4:3:2:1、3:2:4:1、2:1:6:1、3:3:1:3、2:2:1:5或1:1:1:7。6. composition according to claim 5, wherein, described oil-soluble auxiliary agent is jojoba oil, white chia seed oil, caprylic capric triglyceride and isooctyl palmitate, and its mass proportion is 4 :3:2:1, 3:2:4:1, 2:1:6:1, 3:3:1:3, 2:2:1:5, or 1:1:1:7.7.根据权利要求1-4任一项所述的组合物，其中，所述富勒烯为空心富勒烯、金属富勒烯、杂环富勒烯和内嵌富勒烯中的至少一种，包括富勒烯C_2n、M@C_2n、M₂@C_2n、MA@C_2n、M₃N@C_2n、M₂C₂@C_2n、M₂S@C_2n、M₂O@C_2n和M_xA_3-xN@C_2n中的任一种或其混合物，其中，M和A均为金属元素，所述M和A均选自Sc、Y和镧系金属元素中的任意一种；30≤n≤60；0≤x≤3。7. The composition according to any one of claims 1-4, wherein the fullerene is at least one of a hollow fullerene, a metallofullerene, a heterocyclic fullerene and an endofullerene species, including fullerenes C_2n , M@C_2n , M₂ @C_2n , MA@C_2n , M₃ N@C_2n , M₂ C₂ @C_2n , M₂ S@C_2n , M₂ O Any one of @C_2n and M_x A_3-x N@C_2n or a mixture thereof, wherein both M and A are metal elements, and both M and A are selected from Sc, Y and lanthanide metal elements 30≤n≤60; 0≤x≤3.8.根据权利要求7所述的组合物，其中，所述富勒烯为C60、C70、C76、C84，Gd@C82中的任意一种或其混合物。8. The composition according to claim 7, wherein the fullerene is any one of C60, C70, C76, C84, Gd@C82 or a mixture thereof.9.根据权利要求8所述的组合物，其中，所述富勒烯为C60。9. The composition of claim 8, wherein the fullerene is C60.10.一种富勒烯分散体系，所述体系含有富勒烯和油溶性助剂，其特征在于，所述油溶性助剂包括荷荷芭油、白池花籽油、辛酸癸酸甘油三酯和棕榈酸异辛酯，所述分散体系中50％以上的粒径小于5nm。10. A fullerene dispersion system, the system contains fullerenes and an oil-soluble auxiliary agent, wherein the oil-soluble auxiliary agent comprises jojoba oil, white chia seed oil, caprylic capric triglyceride and isooctyl palmitate, more than 50% of the particle sizes in the dispersion system are less than 5 nm.11.根据权利要求7所述的富勒烯分散体系，其中，所述分散体系中60％、70％、80％、90％、95％或99％以上的粒径小于5nm。11. The fullerene dispersion system according to claim 7, wherein more than 60%, 70%, 80%, 90%, 95% or 99% of the particle size in the dispersion system is less than 5 nm.12.根据权利要求7所述的分散体系，其中，除了油溶性助剂和富勒烯之外，还含有至少一种抗氧化剂。12. The dispersion system according to claim 7, wherein, in addition to the oil-soluble auxiliary agent and fullerene, at least one antioxidant is contained.13.根据权利要求7所述的分散体系，其中，除了油溶性助剂和富勒烯之外，还含有至少一种另外的活性成分。13. The dispersion system according to claim 7, which, in addition to the oil-soluble auxiliary and fullerene, contains at least one further active ingredient.14.根据权利要求7所述的分散体系，其中，所述分散体系加入到化妆品或药物递送系统和/或缓释系统中。14. The dispersion system of claim 7, wherein the dispersion system is incorporated into a cosmetic or drug delivery system and/or a sustained release system.15.根据权利要求10-14任一项的分散体系，其中，所述油溶性助剂为荷荷巴油、白池花籽油、辛酸癸酸甘油三酯和棕榈酸异辛酯，其质量配比为(1-7)：(1-7)：(1-7)：(1-7)。15. The dispersion system according to any one of claims 10-14, wherein the oil-soluble adjuvant is jojoba oil, white chia seed oil, caprylic acid capric triglyceride and isooctyl palmitate, the quality of which is The ratio is (1-7):(1-7):(1-7):(1-7).16.根据权利要求15所述的分散体系，其中，所述油溶性助剂为荷荷巴油、白池花籽油、辛酸癸酸甘油三酯和棕榈酸异辛酯，其质量配比为4:3:2:1、3:2:4:1、2:1:6:1、3:3:1:3、2:2:1:5或1:1:1:7。16. The dispersion system according to claim 15, wherein the oil-soluble auxiliary agent is jojoba oil, white chia seed oil, caprylic acid capric triglyceride and isooctyl palmitate, and its mass proportion is 4 :3:2:1, 3:2:4:1, 2:1:6:1, 3:3:1:3, 2:2:1:5, or 1:1:1:7.17.根据权利要求10-14任一项所述的分散体系，其中，所述富勒烯为空心富勒烯、金属富勒烯、杂环富勒烯和内嵌富勒烯中的至少一种，包括富勒烯C_2n、M@C_2n、M₂@C_2n、MA@C_2n、M₃N@C_2n、M₂C₂@C_2n、M₂S@C_2n、M₂O@C_2n和M_xA_3-xN@C_2n中的任一种或其混合物，其中，M和A均为金属元素，所述M和A均选自Sc、Y和镧系金属元素中的任意一种；30≤n≤60；0≤x≤3。17. The dispersion system according to any one of claims 10-14, wherein the fullerene is at least one of a hollow fullerene, a metallofullerene, a heterocyclic fullerene and an endofullerene species, including fullerenes C_2n , M@C_2n , M₂ @C_2n , MA@C_2n , M₃ N@C_2n , M₂ C₂ @C_2n , M₂ S@C_2n , M₂ O Any one of @C_2n and M_x A_3-x N@C_2n or a mixture thereof, wherein both M and A are metal elements, and both M and A are selected from Sc, Y and lanthanide metal elements 30≤n≤60; 0≤x≤3.18.根据权利要求17所述的分散体系，其中，所述富勒烯为C60、C70、C76、C84，Gd@C82中的任意一种或其混合物。18. The dispersion system according to claim 17, wherein the fullerene is any one of C60, C70, C76, C84, Gd@C82 or a mixture thereof.19.根据权利要求18所述的分散体系，其中，所述富勒烯为C60。19. The dispersion system of claim 18, wherein the fullerene is C60.20.一种富勒烯组合物或者分散体系的制备方法，其特征在于，所述方法包括如下步骤：取富勒烯粉末，油溶性助剂，所述油溶性助剂包括荷荷芭油、白池花籽油、辛酸癸酸甘油三酯和棕榈酸异辛酯，混合均匀后，通过高压均质机处理后，离心和/或过滤得到产物。20. A method for preparing a fullerene composition or dispersion system, wherein the method comprises the steps of: taking fullerene powder, an oil-soluble auxiliary agent, and the oil-soluble auxiliary agent comprises jojoba oil, White chia seed oil, caprylic capric triglyceride and isooctyl palmitate are mixed uniformly, processed by a high pressure homogenizer, and centrifuged and/or filtered to obtain a product.21.根据权利要求20所述的制备方法，其中，所述高压均质机在50-500MPa均质。21. The preparation method according to claim 20, wherein the high pressure homogenizer is homogenized at 50-500 MPa.22.权利要求20所述的制备方法，其中，所述高压均质机在100-300MPa均质。22. The preparation method of claim 20, wherein the high-pressure homogenizer is homogenized at 100-300 MPa.23.权利要求20所述的制备方法，其中，所述高压均质机在200MPa均质。23. The preparation method of claim 20, wherein the high-pressure homogenizer is homogenized at 200 MPa.24.权利要求20所述的制备方法，其中，所述高压均质机均质1-10次。24. The preparation method of claim 20, wherein the high-pressure homogenizer is homogenized 1-10 times.25.权利要求20所述的制备方法，其中，所述高压均质机均质3-8次。25. The preparation method of claim 20, wherein the high pressure homogenizer is homogenized 3-8 times.26.权利要求20所述的制备方法，其中，所述高压均质机均质5次。26. The preparation method of claim 20, wherein the high-pressure homogenizer is homogenized 5 times.27.权利要求20所述的制备方法，其中，通过高压均质机处理后将物料温度控制在0-25℃。27. The preparation method of claim 20, wherein the temperature of the material is controlled at 0-25°C after being processed by a high pressure homogenizer.28.权利要求20所述的制备方法，其中，通过高压均质机处理后将物料温度控制在5-20℃。28. The preparation method of claim 20, wherein the temperature of the material is controlled at 5-20°C after being processed by a high pressure homogenizer.29.权利要求20所述的制备方法，其中，通过高压均质机处理后将物料温度控制在10-15℃。29. The preparation method of claim 20, wherein the temperature of the material is controlled at 10-15°C after being processed by a high pressure homogenizer.30.权利要求20所述的制备方法，其中，通过高压均质机处理后搅拌1-20h。30. The preparation method of claim 20, wherein, after being treated by a high pressure homogenizer, the mixture is stirred for 1-20 h.31.权利要求20所述的制备方法，其中，通过高压均质机处理后搅拌5-15h。31. The preparation method of claim 20, wherein, after being treated by a high pressure homogenizer, the mixture is stirred for 5-15h.32.权利要求20所述的制备方法，其中，通过高压均质机处理后搅拌12h。32. The preparation method of claim 20, wherein, after being treated by a high pressure homogenizer, the mixture is stirred for 12h.33.权利要求20-32任一项所述的制备方法制备得到的制备产物。33. The preparation product prepared by the preparation method according to any one of claims 20-32.34.根据权利要求20-32任一项所述的方法，其中，所述油溶性助剂为荷荷巴油、白池花籽油、辛酸癸酸甘油三酯和棕榈酸异辛酯，其质量配比为(1-7)：(1-7)：(1-7)：(1-7)。34. The method according to any one of claims 20-32, wherein the oil-soluble adjuvant is jojoba oil, white chia seed oil, caprylic capric triglyceride and isooctyl palmitate, the quality of which is The ratio is (1-7):(1-7):(1-7):(1-7).35.根据权利要求34所述的方法，其中，所述油溶性助剂为荷荷巴油、白池花籽油、辛酸癸酸甘油三酯和棕榈酸异辛酯，其质量配比为4:3:2:1、3:2:4:1、2:1:6:1、3:3:1:3、2:2:1:5或1:1:1:7。35. method according to claim 34, wherein, described oil-soluble auxiliary agent is jojoba oil, white chia seed oil, caprylic capric triglyceride and isooctyl palmitate, and its mass proportion is 4: 3:2:1, 3:2:4:1, 2:1:6:1, 3:3:1:3, 2:2:1:5, or 1:1:1:7.36.根据权利要求20-32任一项所述的方法，其中，所述富勒烯为空心富勒烯、金属富勒烯、杂环富勒烯和内嵌富勒烯中的至少一种，包括富勒烯C_2n、M@C_2n、M₂@C_2n、MA@C_2n、M₃N@C_2n、M₂C₂@C_2n、M₂S@C_2n、M₂O@C_2n和M_xA_3-xN@C_2n中的任一种或其混合物，其中，M和A均为金属元素，所述M和A均选自Sc、Y和镧系金属元素中的任意一种；30≤n≤60；0≤x≤3。36. The method of any one of claims 20-32, wherein the fullerene is at least one of a hollow fullerene, a metallofullerene, a heterocyclic fullerene, and an endofullerene , including fullerenes C_2n , M@C_2n , M₂ @C_2n , MA@C_2n , M₃ N@C_2n , M₂ C₂ @C_2n , M₂ S@C_2n , M₂ O@ Any one of C_2n and M_x A_3-x N@C_2n or a mixture thereof, wherein M and A are both metal elements, and both M and A are selected from Sc, Y and lanthanide metal elements Any one; 30≤n≤60; 0≤x≤3.37.根据权利要求36所述的方法，其中，所述富勒烯为C60、C70、C76、C84，Gd@C82中的任意一种或其混合物。37. The method of claim 36, wherein the fullerene is any one of C60, C70, C76, C84, Gd@C82 or a mixture thereof.38.根据权利要求37所述的方法，其中，所述富勒烯为C60。38. The method of claim 37, wherein the fullerene is C60.39.权利要求1-9任一项所述的组合物在制备美容或化妆用品中的用途。39. Use of the composition of any one of claims 1-9 in the preparation of a cosmetic or cosmetic product.40.根据权利要求39所述的用途，其中，所述美容或化妆用品用于美白祛斑、祛皱、抗痘、防霾或生发固发的至少一种。40. The use according to claim 39, wherein the cosmetic or cosmetic product is used for at least one of whitening and freckle removal, wrinkle removal, anti-acne, haze prevention, or hair growth and hair growth.41.权利要求10-19任一项所述的分散体系在制备美容或化妆用品中的用途。41. Use of the dispersion system of any one of claims 10-19 in the preparation of cosmetic or cosmetic products.42.根据权利要求41所述的用途，其中，所述美容或化妆用品用于美白祛斑、祛皱、抗痘、防霾或生发固发的至少一种。42. The use according to claim 41, wherein the cosmetic or cosmetic product is used for at least one of whitening and freckle removal, wrinkle removal, anti-acne, anti-haze or hair growth and maintenance.43.权利要求1-9任一项的组合物在制备用于美容或化妆的器械中的用途。43. Use of a composition according to any one of claims 1 to 9 in the manufacture of a device for cosmetic or cosmetic use.44.根据权利要求43所述的用途，其中，所述美容或化妆器械用于美白祛斑、祛皱、抗痘、防霾或生发固发的至少一种。44. The use according to claim 43, wherein the cosmetic or cosmetic device is used for at least one of whitening and freckle-removing, wrinkle-removing, anti-acne, anti-haze, or hair growth and fixation.45.权利要求10-19任一项的分散体系在制备用于美容或化妆的器械中的用途。45. Use of a dispersion system according to any one of claims 10 to 19 in the manufacture of a device for cosmetic or cosmetic use.46.根据权利要求45所述的用途，其中，所述美容或化妆器械用于美白祛斑、祛皱、抗痘、防霾或生发固发的至少一种。46. The use according to claim 45, wherein the cosmetic or cosmetic device is used for at least one of whitening and freckle removal, wrinkle removal, anti-acne, haze prevention, or hair growth and maintenance.

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